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Name

Human IO with Add-on

#2110

Species

Homo sapiens

# Genes

493

# Serial Genes

Description

Covers key immune and cancer cell types, biomarkers, and pathways, with broad cell type markers for context. Includes serial add-on genes.

Genes & Annotations

Reactome is a database of signaling and metabolic molecules organized into heirarchical pathways and relationships. Here we show the high level pathways, except 'Disease'. You can click on the pathway to see the full heirarchy and which levels are impacted by genes in the panel.

Annotation	Genes
ATP-dependent chromatin remodelers Pathway Hierarchies & Genes Formation of the canonical BAF (cBAF) complex (1 genes) Chromatin organization ATP-dependent chromatin remodelers SWI/SNF chromatin remodelers Formation of the canonical BAF (cBAF) complex 1 genes	SMARCA4 Gene Information Basic Information Ensembl ID: ENSG00000127616 Description: SWI/SNF related%2C matrix associated%2C actin dependent regulator of chromatin%2C subfamily a%2C member 4 [Source:HGNC Symbol;Acc:HGNC:11100] Location: 19:10960932-11079426 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell epithelial cell fibroblast Other: Cytokine Signaling in Immune system Signaling by WNT Epigenetic regulation of gene expression
Activation of HOX genes during differentiation Pathway Hierarchies & Genes Activation of anterior HOX genes in hindbrain development during early embryogenesis (3 genes) Developmental Biology Activation of HOX genes during differentiation Activation of anterior HOX genes in hindbrain development during early embryogenesis 3 genes	CREBBP Gene Information Basic Information Ensembl ID: ENSG00000005339 Description: CREB binding protein [Source:HGNC Symbol;Acc:HGNC:2348] Location: 16:3725054-3880713 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes BMAL1:CLOCK,NPAS2 activates circadian expression EZH2 Gene Information Basic Information Ensembl ID: ENSG00000106462 Description: enhancer of zeste 2 polycomb repressive complex 2 subunit [Source:HGNC Symbol;Acc:HGNC:3527] Location: 7:148807257-148884321 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell Other: Epigenetic regulation of gene expression Cellular responses to stress Chromatin modifying enzymes HDAC3 Gene Information Basic Information Ensembl ID: ENSG00000171720 Description: histone deacetylase 3 [Source:HGNC Symbol;Acc:HGNC:4854] Location: 5:141620876-141636849 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Death Receptor Signaling Signaling by NOTCH Mitochondrial biogenesis
Adaptive Immune System Pathway Hierarchies & Genes Downstream TCR signaling (5 genes) Immune System Adaptive Immune System Signaling by the B Cell Receptor (BCR) Downstream signaling events of B Cell Receptor (BCR) Activation of NF-kappaB in B cells Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation 3 genes ER-Phagosome pathway TCR signaling Downstream TCR signaling 2 genes Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (10 genes) Immune System Adaptive Immune System Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation ER-Phagosome pathway 9 genes Signaling by the B Cell Receptor (BCR) Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 1 genes Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (10 genes) Immune System Adaptive Immune System Regulation of T cell activation by CD28 family Co-stimulation by CD28 CD28 dependent PI3K/Akt signaling 8 genes Signaling by the B Cell Receptor (BCR) Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 2 genes CD28 dependent PI3K/Akt signaling (5 genes) Immune System Adaptive Immune System TCR signaling Downstream TCR signaling 1 genes Regulation of T cell activation by CD28 family Co-stimulation by CD28 1 genes CD28 dependent PI3K/Akt signaling 3 genes Co-inhibition by PD-1 (38 genes) Immune System Adaptive Immune System Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 34 genes TCR signaling Downstream TCR signaling 2 genes Regulation of T cell activation by CD28 family Co-inhibition by PD-1 2 genes CD22 mediated BCR regulation (2 genes) Immune System Adaptive Immune System Regulation of T cell activation by CD28 family Co-stimulation by CD28 1 genes Signaling by the B Cell Receptor (BCR) CD22 mediated BCR regulation 1 genes Activation of RAS in B cells (3 genes) Immune System Adaptive Immune System Signaling by the B Cell Receptor (BCR) Downstream signaling events of B Cell Receptor (BCR) Activation of RAS in B cells 3 genes Calcineurin activates NFAT (1 genes) Immune System Adaptive Immune System Signaling by the B Cell Receptor (BCR) Downstream signaling events of B Cell Receptor (BCR) Calcineurin activates NFAT 1 genes Cross-presentation of particulate exogenous antigens (phagosomes) (1 genes) Immune System Adaptive Immune System Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Cross-presentation of particulate exogenous antigens (phagosomes) 1 genes Cross-presentation of soluble exogenous antigens (endosomes) (1 genes) Immune System Adaptive Immune System Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Cross-presentation of soluble exogenous antigens (endosomes) 1 genes Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (2 genes) Immune System Adaptive Immune System Signaling by the B Cell Receptor (BCR) Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 2 genes Antigen processing: Ubiquitination & Proteasome degradation (2 genes) Immune System Adaptive Immune System Class I MHC mediated antigen processing & presentation Antigen processing: Ubiquitination & Proteasome degradation 2 genes CD22 mediated BCR regulation (2 genes) Immune System Adaptive Immune System Signaling by the B Cell Receptor (BCR) CD22 mediated BCR regulation 2 genes Co-inhibition by BTLA (2 genes) Immune System Adaptive Immune System Regulation of T cell activation by CD28 family Co-inhibition by BTLA 2 genes Co-inhibition by CTLA4 (1 genes) Immune System Adaptive Immune System Regulation of T cell activation by CD28 family Co-inhibition by CTLA4 1 genes Co-inhibition by PD-1 (3 genes) Immune System Adaptive Immune System Regulation of T cell activation by CD28 family Co-inhibition by PD-1 3 genes Co-stimulation by ICOS (2 genes) Immune System Adaptive Immune System Regulation of T cell activation by CD28 family Co-stimulation by ICOS 2 genes Generation of second messenger molecules (1 genes) Immune System Adaptive Immune System TCR signaling Generation of second messenger molecules 1 genes Phosphorylation of CD3 and TCR zeta chains (1 genes) Immune System Adaptive Immune System TCR signaling Phosphorylation of CD3 and TCR zeta chains 1 genes Translocation of ZAP-70 to Immunological synapse (1 genes) Immune System Adaptive Immune System TCR signaling Translocation of ZAP-70 to Immunological synapse 1 genes Butyrophilin (BTN) family interactions (1 genes) Immune System Adaptive Immune System Butyrophilin (BTN) family interactions 1 genes MHC class II antigen presentation (3 genes) Immune System Adaptive Immune System MHC class II antigen presentation 3 genes	AKT1 Gene Information Basic Information Ensembl ID: ENSG00000142208 Description: AKT serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:391] Location: 14:104769349-104795759 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Integrin signaling Apoptosis Cytokine Signaling in Immune system AKT2 Gene Information Basic Information Ensembl ID: ENSG00000105221 Description: AKT serine/threonine kinase 2 [Source:HGNC Symbol;Acc:HGNC:392] Location: 19:40230317-40285536 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: T cell Other: Apoptosis Cytokine Signaling in Immune system Adaptive Immune System AKT3 Gene Information Basic Information Ensembl ID: ENSG00000117020 Description: AKT serine/threonine kinase 3 [Source:HGNC Symbol;Acc:HGNC:393] Location: 1:243488233-243851079 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell neuron epithelial cell T cell fibroblast glial cell CD8+ T cell schwann cell Specialized T cell excitatory neuron smooth muscle cell Other: Apoptosis Cytokine Signaling in Immune system Adaptive Immune System BLK Gene Information Basic Information Ensembl ID: ENSG00000136573 Description: BLK proto-oncogene%2C Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:1057] Location: 8:11486894-11564599 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell CD4+ T cell Follicular B cell memory B cell Other: Adaptive Immune System RNA Polymerase II Transcription BTK Gene Information Basic Information Ensembl ID: ENSG00000010671 Description: Bruton tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:1133] Location: X:101349338-101390796 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell Naive B cell mast cell granulocyte Other: Adaptive Immune System Innate Immune System Signaling by GPCR BTLA Gene Information Basic Information Ensembl ID: ENSG00000186265 Description: B and T lymphocyte associated [Source:HGNC Symbol;Acc:HGNC:21087] Location: 3:112461067-112499472 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell CD4+ T cell Other: Adaptive Immune System CARD11 Gene Information Basic Information Ensembl ID: ENSG00000198286 Description: caspase recruitment domain family member 11 [Source:HGNC Symbol;Acc:HGNC:16393] Location: 7:2906142-3044228 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell CD8+ T cell developing T cell dendritic cell lymphoid progenitor cell T cell Specialized T cell innate lymphoid cell leukocyte lymphocyte Other: Adaptive Immune System Innate Immune System CBLB Gene Information Basic Information Ensembl ID: ENSG00000114423 Description: Cbl proto-oncogene B [Source:HGNC Symbol;Acc:HGNC:1542] Location: 3:105655461-105869552 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell natural killer cell cardiomyocyte developing T cell T cell stem cell fibroblast Specialized T cell CD4+ T cell CD8+ T cell macrophage podocyte Other: Adaptive Immune System CD14 Gene Information Basic Information Ensembl ID: ENSG00000170458 Description: CD14 molecule [Source:HGNC Symbol;Acc:HGNC:1628] Location: 5:140631728-140633700 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell macrophage dendritic cell phagocyte myeloid cell antigen presenting cell monocyte Other: Apoptosis Adaptive Immune System Innate Immune System CD160 Gene Information Basic Information Ensembl ID: ENSG00000117281 Description: CD160 molecule [Source:HGNC Symbol;Acc:HGNC:17013] Location: 1:145719471-145739288 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell innate lymphoid cell Specialized T cell CD8+ T cell Other: Adaptive Immune System CD19 Gene Information Basic Information Ensembl ID: ENSG00000177455 Description: CD19 molecule [Source:HGNC Symbol;Acc:HGNC:1633] Location: 16:28931965-28939342 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell Follicular B cell Regulatory plasma cell cancer cell follicular cell plasmablast memory B cell fibroblast Other: Adaptive Immune System Innate Immune System Intracellular signaling by second messengers CD1A Gene Information Basic Information Ensembl ID: ENSG00000158477 Description: CD1a molecule [Source:HGNC Symbol;Acc:HGNC:1634] Location: 1:158254424-158258269 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell developing T cell monocyte Other: Adaptive Immune System CD1B Gene Information Basic Information Ensembl ID: ENSG00000158485 Description: CD1b molecule [Source:HGNC Symbol;Acc:HGNC:1635] Location: 1:158327951-158331531 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: developing T cell dendritic cell Other: Adaptive Immune System CD1C Gene Information Basic Information Ensembl ID: ENSG00000158481 Description: CD1c molecule [Source:HGNC Symbol;Acc:HGNC:1636] Location: 1:158289923-158294774 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell T cell memory B cell marginal B cell Other: Adaptive Immune System CD1D Gene Information Basic Information Ensembl ID: ENSG00000158473 Description: CD1d molecule [Source:HGNC Symbol;Acc:HGNC:1637] Location: 1:158178030-158186427 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: monocyte Other: Adaptive Immune System CD200 Gene Information Basic Information Ensembl ID: ENSG00000091972 Description: CD200 molecule [Source:HGNC Symbol;Acc:HGNC:7203] Location: 3:112332235-112363181 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell CD4+ T cell endocrine cell stem cell Other: Adaptive Immune System CD209 Gene Information Basic Information Ensembl ID: ENSG00000090659 Description: CD209 molecule [Source:HGNC Symbol;Acc:HGNC:1641] Location: 19:7739993-7747564 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: phagocyte myeloid cell dendritic cell macrophage Other: Adaptive Immune System Innate Immune System Viral Infection Pathways CD22 Gene Information Basic Information Ensembl ID: ENSG00000012124 Description: CD22 molecule [Source:HGNC Symbol;Acc:HGNC:1643] Location: 19:35319261-35347361 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell fibroblast mast cell Follicular B cell secretory cell marginal B cell Other: Adaptive Immune System CD274 Gene Information Basic Information Ensembl ID: ENSG00000120217 Description: CD274 molecule [Source:HGNC Symbol;Acc:HGNC:17635] Location: 9:5450503-5470566 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: lymphocyte memory T cell CD8+ T cell CD4+ T cell Other: Adaptive Immune System Signaling by Receptor Tyrosine Kinases CD28 Gene Information Basic Information Ensembl ID: ENSG00000178562 Description: CD28 molecule [Source:HGNC Symbol;Acc:HGNC:1653] Location: 2:203706517-203739756 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell developing T cell Regulatory T cell CD8+ T cell CD4+ T cell T cell Specialized T cell Other: Adaptive Immune System Intracellular signaling by second messengers PI3K/AKT Signaling in Cancer CD33 Gene Information Basic Information Ensembl ID: ENSG00000105383 Description: CD33 molecule [Source:HGNC Symbol;Acc:HGNC:1659] Location: 19:51225064-51243860 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: mast cell myeloid cell myeloid derived suppressor cell blast cell peripheral blood mononuclear cell macrophage dendritic cell progenitor monocyte granulocyte Other: Adaptive Immune System Innate Immune System CD3D Gene Information Basic Information Ensembl ID: ENSG00000167286 Description: CD3 delta subunit of T-cell receptor complex [Source:HGNC Symbol;Acc:HGNC:1673] Location: 11:118334537-118342705 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell CD8+ T cell developing T cell lymphocyte T cell Specialized T cell Regulatory T cell CD4+ T cell Other: Adaptive Immune System Membrane Trafficking CD3E Gene Information Basic Information Ensembl ID: ENSG00000198851 Description: CD3 epsilon subunit of T-cell receptor complex [Source:HGNC Symbol;Acc:HGNC:1674] Location: 11:118304730-118316175 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell CD8+ T cell developing T cell lymphocyte CD4+ T cell T cell Other: Adaptive Immune System CD4 Gene Information Basic Information Ensembl ID: ENSG00000010610 Description: CD4 molecule [Source:HGNC Symbol;Acc:HGNC:1678] Location: 12:6786858-6820799 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell dendritic cell phagocyte CD4+ T cell antigen presenting cell hematopoietic cell monocyte macrophage developing T cell Regulatory T cell T cell memory T cell Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System CD40 Gene Information Basic Information Ensembl ID: ENSG00000101017 Description: CD40 molecule [Source:HGNC Symbol;Acc:HGNC:11919] Location: 20:46118271-46129863 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell dendritic cell Follicular B cell memory B cell macrophage Other: Cytokine Signaling in Immune system Adaptive Immune System CD40LG Gene Information Basic Information Ensembl ID: ENSG00000102245 Description: CD40 ligand [Source:HGNC Symbol;Acc:HGNC:11935] Location: X:136648158-136660390 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell developing T cell T cell CD4+ T cell T helper cell Other: Cytokine Signaling in Immune system Adaptive Immune System CD74 Gene Information Basic Information Ensembl ID: ENSG00000019582 Description: CD74 molecule [Source:HGNC Symbol;Acc:HGNC:1697] Location: 5:150401637-150412969 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell dendritic cell macrophage monocyte phagocyte Follicular B cell glial cell microglia Other: Adaptive Immune System Cell surface interactions at the vascular wall Developmental Cell Lineages CD79A Gene Information Basic Information Ensembl ID: ENSG00000105369 Description: CD79a molecule [Source:HGNC Symbol;Acc:HGNC:1698] Location: 19:41877279-41881372 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell lymphoid progenitor cell lymphocyte Follicular B cell plasma cell Other: Adaptive Immune System Viral Infection Pathways CD79B Gene Information Basic Information Ensembl ID: ENSG00000007312 Description: CD79b molecule [Source:HGNC Symbol;Acc:HGNC:1699] Location: 17:63928738-63932336 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell lymphoid progenitor cell Follicular B cell Other: Adaptive Immune System Viral Infection Pathways CD80 Gene Information Basic Information Ensembl ID: ENSG00000121594 Description: CD80 molecule [Source:HGNC Symbol;Acc:HGNC:1700] Location: 3:119524293-119559614 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell Other: Cytokine Signaling in Immune system Adaptive Immune System Intracellular signaling by second messengers CD86 Gene Information Basic Information Ensembl ID: ENSG00000114013 Description: CD86 molecule [Source:HGNC Symbol;Acc:HGNC:1705] Location: 3:122055362-122121139 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell macrophage phagocyte monocyte immune cell Other: Cytokine Signaling in Immune system Adaptive Immune System Intracellular signaling by second messengers CD8A Gene Information Basic Information Ensembl ID: ENSG00000153563 Description: CD8 subunit alpha [Source:HGNC Symbol;Acc:HGNC:1706] Location: 2:86784610-86808396 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell CD8+ T cell developing T cell T cell Specialized T cell lymphocyte cytotoxic lymphocyte Other: Adaptive Immune System CD96 Gene Information Basic Information Ensembl ID: ENSG00000153283 Description: CD96 molecule [Source:HGNC Symbol;Acc:HGNC:16892] Location: 3:111292719-111665996 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell CD8+ T cell developing T cell T cell CD4+ T cell Specialized T cell lymphocyte stem cell leukocyte Other: Adaptive Immune System CDH1 Gene Information Basic Information Ensembl ID: ENSG00000039068 Description: cadherin 1 [Source:HGNC Symbol;Acc:HGNC:1748] Location: 16:68737292-68835537 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: goblet cell epithelial cell pneumocyte stem cell secretory cell tuft cell paneth cell ciliated cell neuroendocrine cell brush cell basal cell serous cell deuterosomal cell club Other: Apoptosis Adaptive Immune System Degradation of the extracellular matrix CHUK Gene Information Basic Information Ensembl ID: ENSG00000213341 Description: component of inhibitor of nuclear factor kappa B kinase complex [Source:HGNC Symbol;Acc:HGNC:1974] Location: 10:100188300-100229596 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Intracellular signaling by second messengers Cytokine Signaling in Immune system Adaptive Immune System CTLA4 Gene Information Basic Information Ensembl ID: ENSG00000163599 Description: cytotoxic T-lymphocyte associated protein 4 [Source:HGNC Symbol;Acc:HGNC:2505] Location: 2:203853888-203873965 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: developing T cell Regulatory T cell CD4+ T cell CD8+ T cell immune cell Other: Adaptive Immune System RNA Polymerase II Transcription FYN Gene Information Basic Information Ensembl ID: ENSG00000010810 Description: FYN proto-oncogene%2C Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:4037] Location: 6:111660332-111873452 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Cellular responses to mechanical stimuli HLA-DMA Gene Information Basic Information Ensembl ID: ENSG00000204257 Description: major histocompatibility complex%2C class II%2C DM alpha [Source:HGNC Symbol;Acc:HGNC:4934] Location: 6:32948613-32969094 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell dendritic cell macrophage phagocyte microglia Follicular B cell antigen presenting cell monocyte Other: Adaptive Immune System HLA-DQA1 Gene Information Basic Information Ensembl ID: ENSG00000196735 Description: major histocompatibility complex%2C class II%2C DQ alpha 1 [Source:HGNC Symbol;Acc:HGNC:4942] Location: 6:32628179-32647062 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell macrophage Naive B cell phagocyte Follicular B cell antigen presenting cell monocyte Other: Cytokine Signaling in Immune system Adaptive Immune System HRAS Gene Information Basic Information Ensembl ID: ENSG00000174775 Description: HRas proto-oncogene%2C GTPase [Source:HGNC Symbol;Acc:HGNC:5173] Location: 11:532242-537321 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Transmission across Chemical Synapses Cytokine Signaling in Immune system Adaptive Immune System ICAM1 Gene Information Basic Information Ensembl ID: ENSG00000090339 Description: intercellular adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:5344] Location: 19:10271093-10286615 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell endothelial cell natural killer cell dendritic cell phagocyte stromal cell pancreatic cell granulocyte macrophage kupffer cell fibroblast Other: Cytokine Signaling in Immune system Adaptive Immune System Integrin cell surface interactions ICAM2 Gene Information Basic Information Ensembl ID: ENSG00000108622 Description: intercellular adhesion molecule 2 [Source:HGNC Symbol;Acc:HGNC:5345] Location: 17:64002594-64020634 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell cardiomyocyte megakaryocyte Other: Adaptive Immune System Innate Immune System Integrin cell surface interactions ICAM3 Gene Information Basic Information Ensembl ID: ENSG00000076662 Description: intercellular adhesion molecule 3 [Source:HGNC Symbol;Acc:HGNC:5346] Location: 19:10333776-10339661 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell developing T cell hematopoietic stem cell CD4+ T cell Specialized T cell monocyte innate lymphoid cell lymphocyte Other: Adaptive Immune System Innate Immune System Integrin cell surface interactions ICOS Gene Information Basic Information Ensembl ID: ENSG00000163600 Description: inducible T cell costimulator [Source:HGNC Symbol;Acc:HGNC:5351] Location: 2:203936763-203961577 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: developing T cell Regulatory T cell CD4+ T cell memory T cell T helper cell T cell Other: Adaptive Immune System Intracellular signaling by second messengers PI3K/AKT Signaling in Cancer ICOSLG Gene Information Basic Information Ensembl ID: ENSG00000160223 Description: inducible T cell costimulator ligand [Source:HGNC Symbol;Acc:HGNC:17087] Location: 21:44215382-44241446 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Adaptive Immune System IKBKB Gene Information Basic Information Ensembl ID: ENSG00000104365 Description: inhibitor of nuclear factor kappa B kinase subunit beta [Source:HGNC Symbol;Acc:HGNC:5960] Location: 8:42271302-42332460 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell secretory cell T cell Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System ITGA4 Gene Information Basic Information Ensembl ID: ENSG00000115232 Description: integrin subunit alpha 4 [Source:HGNC Symbol;Acc:HGNC:6140] Location: 2:181457202-181538940 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell developing T cell Naive B cell Specialized T cell mast cell lymphoid progenitor cell CD8+ T cell erythroid lineage cell T cell memory T cell progenitor cell erythroblast projection neuron Other: Cell surface interactions at the vascular wall Integrin cell surface interactions Adaptive Immune System ITGAL Gene Information Basic Information Ensembl ID: ENSG00000005844 Description: integrin subunit alpha L [Source:HGNC Symbol;Acc:HGNC:6148] Location: 16:30472658-30523567 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell developing T cell T cell Specialized T cell CD4+ T cell lymphoid progenitor cell CD8+ T cell natural killer cell innate lymphoid cell leukocyte monocyte Other: Adaptive Immune System Innate Immune System Cell surface interactions at the vascular wall ITGAV Gene Information Basic Information Ensembl ID: ENSG00000138448 Description: integrin subunit alpha V [Source:HGNC Symbol;Acc:HGNC:6150] Location: 2:186590010-186680901 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell glial cell stromal cell M cell endothelial cell Other: Adaptive Immune System Elastic fibre formation Innate Immune System ITGB1 Gene Information Basic Information Ensembl ID: ENSG00000150093 Description: integrin subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:6153] Location: 10:32887273-33005792 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stellate cell pericyte trophoblast cell epithelial cell stromal cell stem cell endothelial cell smooth muscle cell fibroblast mesenchymal stem cell Other: Laminin interactions Cell surface interactions at the vascular wall Cytokine Signaling in Immune system ITGB2 Gene Information Basic Information Ensembl ID: ENSG00000160255 Description: integrin subunit beta 2 [Source:HGNC Symbol;Acc:HGNC:6155] Location: 21:44885953-44931989 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell natural killer cell memory T cell developing T cell macrophage dendritic cell phagocyte leukocyte T cell Specialized T cell monocyte Other: Adaptive Immune System Cytokine Signaling in Immune system Innate Immune System ITGB7 Gene Information Basic Information Ensembl ID: ENSG00000139626 Description: integrin subunit beta 7 [Source:HGNC Symbol;Acc:HGNC:6162] Location: 12:53191323-53207282 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: CD4+ T cell T cell memory T cell Other: Adaptive Immune System Integrin cell surface interactions ITK Gene Information Basic Information Ensembl ID: ENSG00000113263 Description: IL2 inducible T cell kinase [Source:HGNC Symbol;Acc:HGNC:6171] Location: 5:157142933-157255185 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell CD8+ T cell developing T cell T cell CD4+ T cell cytotoxic lymphocyte cancer cell Other: Adaptive Immune System Innate Immune System KLRC1 Gene Information Basic Information Ensembl ID: ENSG00000134545 Description: killer cell lectin like receptor C1 [Source:HGNC Symbol;Acc:HGNC:6374] Location: 12:10442264-10454685 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell developing T cell innate lymphoid cell interneuron CD8+ T cell T cell Specialized T cell Other: Adaptive Immune System KLRG1 Gene Information Basic Information Ensembl ID: ENSG00000139187 Description: killer cell lectin like receptor G1 [Source:HGNC Symbol;Acc:HGNC:6380] Location: 12:8950044-9010760 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell CD8+ T cell memory T cell Specialized T cell interneuron mast cell endothelial cell T cell short-lived effector cell Other: Adaptive Immune System KLRK1 Gene Information Basic Information Ensembl ID: ENSG00000213809 Description: killer cell lectin like receptor K1 [Source:HGNC Symbol;Acc:HGNC:18788] Location: 12:10372353-10391874 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell CD8+ T cell memory T cell developing T cell Other: Adaptive Immune System Innate Immune System KRAS Gene Information Basic Information Ensembl ID: ENSG00000133703 Description: KRAS proto-oncogene%2C GTPase [Source:HGNC Symbol;Acc:HGNC:6407] Location: 12:25205246-25250936 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Signaling by Non-Receptor Tyrosine Kinases Transmission across Chemical Synapses Cytokine Signaling in Immune system LAG3 Gene Information Basic Information Ensembl ID: ENSG00000089692 Description: lymphocyte activating 3 [Source:HGNC Symbol;Acc:HGNC:6476] Location: 12:6772512-6778455 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: CD8+ T cell developing T cell Regulatory T cell T cell Specialized T cell lymphocyte Other: Adaptive Immune System LAIR1 Gene Information Basic Information Ensembl ID: ENSG00000167613 Description: leukocyte associated immunoglobulin like receptor 1 [Source:HGNC Symbol;Acc:HGNC:6477] Location: 19:54351384-54370558 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: macrophage monocyte Naive B cell leukocyte Other: Adaptive Immune System Innate Immune System LCK Gene Information Basic Information Ensembl ID: ENSG00000182866 Description: LCK proto-oncogene%2C Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6524] Location: 1:32251244-32286165 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell CD8+ T cell developing T cell T cell lymphocyte Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System LYN Gene Information Basic Information Ensembl ID: ENSG00000254087 Description: LYN proto-oncogene%2C Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6735] Location: 8:55879835-56014169 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System MRC1 Gene Information Basic Information Ensembl ID: ENSG00000260314 Description: mannose receptor C-type 1 [Source:HGNC Symbol;Acc:HGNC:7228] Location: 10:17809348-17911164 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell macrophage dendritic cell phagocyte myeloid cell antigen presenting cell hematopoietic cell microglia Other: Adaptive Immune System Bacterial Infection Pathways MTOR Gene Information Basic Information Ensembl ID: ENSG00000198793 Description: mechanistic target of rapamycin kinase [Source:HGNC Symbol;Acc:HGNC:3942] Location: 1:11106535-11262556 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Adaptive Immune System Macroautophagy MTOR signalling MYD88 Gene Information Basic Information Ensembl ID: ENSG00000172936 Description: MYD88 innate immune signal transduction adaptor [Source:HGNC Symbol;Acc:HGNC:7562] Location: 3:38138552-38143024 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: monocyte Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System NCR1 Gene Information Basic Information Ensembl ID: ENSG00000189430 Description: natural cytotoxicity triggering receptor 1 [Source:HGNC Symbol;Acc:HGNC:6731] Location: 19:54906148-54916140 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: innate lymphoid cell T cell natural killer cell Specialized T cell Other: Adaptive Immune System NCR3 Gene Information Basic Information Ensembl ID: ENSG00000204475 Description: natural cytotoxicity triggering receptor 3 [Source:HGNC Symbol;Acc:HGNC:19077] Location: 6:31588895-31593006 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell innate lymphoid cell Specialized T cell T cell CD8+ T cell Other: Adaptive Immune System NFATC1 Gene Information Basic Information Ensembl ID: ENSG00000131196 Description: nuclear factor of activated T cells 1 [Source:HGNC Symbol;Acc:HGNC:7775] Location: 18:79395856-79529325 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell endocardial cell Other: Adaptive Immune System Innate Immune System Signaling by WNT NFKB1 Gene Information Basic Information Ensembl ID: ENSG00000109320 Description: nuclear factor kappa B subunit 1 [Source:HGNC Symbol;Acc:HGNC:7794] Location: 4:102501330-102617302 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System NRAS Gene Information Basic Information Ensembl ID: ENSG00000213281 Description: NRAS proto-oncogene%2C GTPase [Source:HGNC Symbol;Acc:HGNC:7989] Location: 1:114704469-114716771 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell cancer cell Other: Signaling by Erythropoietin Signaling by Non-Receptor Tyrosine Kinases Signaling by Nuclear Receptors PDCD1 Gene Information Basic Information Ensembl ID: ENSG00000188389 Description: programmed cell death 1 [Source:HGNC Symbol;Acc:HGNC:8760] Location: 2:241849884-241858894 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: developing T cell CD4+ T cell CD8+ T cell T cell memory T cell lymphocyte progenitor cell T helper cell Other: Adaptive Immune System Viral Infection Pathways PDCD1LG2 Gene Information Basic Information Ensembl ID: ENSG00000197646 Description: programmed cell death 1 ligand 2 [Source:HGNC Symbol;Acc:HGNC:18731] Location: 9:5510531-5571282 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: schwann cell Other: Adaptive Immune System PIK3CA Gene Information Basic Information Ensembl ID: ENSG00000121879 Description: phosphatidylinositol-4%2C5-bisphosphate 3-kinase catalytic subunit alpha [Source:HGNC Symbol;Acc:HGNC:8975] Location: 3:179148114-179240093 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System PIK3CD Gene Information Basic Information Ensembl ID: ENSG00000171608 Description: phosphatidylinositol-4%2C5-bisphosphate 3-kinase catalytic subunit delta [Source:HGNC Symbol;Acc:HGNC:8977] Location: 1:9629889-9729114 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: developing T cell T cell hematopoietic cell Other: Cytokine Signaling in Immune system Adaptive Immune System Metabolism of lipids PIK3CG Gene Information Basic Information Ensembl ID: ENSG00000105851 Description: phosphatidylinositol-4%2C5-bisphosphate 3-kinase catalytic subunit gamma [Source:HGNC Symbol;Acc:HGNC:8978] Location: 7:106865278-106908980 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: tuft cell Other: Adaptive Immune System Signaling by GPCR Metabolism of lipids PSMB9 Gene Information Basic Information Ensembl ID: ENSG00000240065 Description: proteasome 20S subunit beta 9 [Source:HGNC Symbol;Acc:HGNC:9546] Location: 6:32844136-32860734 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell natural killer cell CD8+ T cell memory T cell developing T cell T cell Regulatory T cell dendritic cell Other: Adaptive Immune System Post-translational protein modification PTPN11 Gene Information Basic Information Ensembl ID: ENSG00000179295 Description: protein tyrosine phosphatase non-receptor type 11 [Source:HGNC Symbol;Acc:HGNC:9644] Location: 12:112418351-112509918 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System PTPRC Gene Information Basic Information Ensembl ID: ENSG00000081237 Description: protein tyrosine phosphatase receptor type C [Source:HGNC Symbol;Acc:HGNC:9666] Location: 1:198638457-198759342 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell CD8+ T cell developing T cell T cell phagocyte monocyte CD4+ T cell leukocyte hematopoietic cell lymphocyte hematopoietic stem cell stromal cell fibroblast immune cell myeloid cell dendritic cell plasma cell neutrophil mesenchymal stem cell epithelial cell endothelial cell macrophage mast cell stem cell Other: Adaptive Immune System Innate Immune System Nervous system development PVR Gene Information Basic Information Ensembl ID: ENSG00000073008 Description: PVR cell adhesion molecule [Source:HGNC Symbol;Acc:HGNC:9705] Location: 19:44643798-44666162 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Adaptive Immune System Cell junction organization RELA Gene Information Basic Information Ensembl ID: ENSG00000173039 Description: RELA proto-oncogene%2C NF-kB subunit [Source:HGNC Symbol;Acc:HGNC:9955] Location: 11:65653599-65663090 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System SELL Gene Information Basic Information Ensembl ID: ENSG00000188404 Description: selectin L [Source:HGNC Symbol;Acc:HGNC:10720] Location: 1:169690665-169711702 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell memory T cell Regulatory T cell Naive B cell T cell dendritic cell lymphoid progenitor cell granulocyte Follicular B cell antigen presenting cell memory B cell monocyte innate lymphoid cell developing T cell neutrophil Other: Adaptive Immune System Innate Immune System Cell surface interactions at the vascular wall SH2D1A Gene Information Basic Information Ensembl ID: ENSG00000183918 Description: SH2 domain containing 1A [Source:HGNC Symbol;Acc:HGNC:10820] Location: X:124227868-124373197 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell CD8+ T cell developing T cell T cell CD4+ T cell Specialized T cell Regulatory T cell Other: Adaptive Immune System SH2D1B Gene Information Basic Information Ensembl ID: ENSG00000198574 Description: SH2 domain containing 1B [Source:HGNC Symbol;Acc:HGNC:30416] Location: 1:162395268-162412138 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell Specialized T cell innate lymphoid cell Other: Adaptive Immune System SIGLEC1 Gene Information Basic Information Ensembl ID: ENSG00000088827 Description: sialic acid binding Ig like lectin 1 [Source:HGNC Symbol;Acc:HGNC:11127] Location: 20:3686970-3712600 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: macrophage phagocyte monocyte hematopoietic cell innate lymphoid cell Other: Adaptive Immune System SLAMF7 Gene Information Basic Information Ensembl ID: ENSG00000026751 Description: SLAM family member 7 [Source:HGNC Symbol;Acc:HGNC:21394] Location: 1:160739057-160754821 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell plasma cell Specialized T cell antigen presenting cell cancer cell Other: Adaptive Immune System SOCS3 Gene Information Basic Information Ensembl ID: ENSG00000184557 Description: suppressor of cytokine signaling 3 [Source:HGNC Symbol;Acc:HGNC:19391] Location: 17:78356778-78360077 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell pericyte fibroblast stromal cell smooth muscle cell CD4+ T cell granulocyte epithelial cell monocyte basal cell developing T cell Other: Cytokine Signaling in Immune system Adaptive Immune System Signaling by Leptin SYK Gene Information Basic Information Ensembl ID: ENSG00000165025 Description: spleen associated tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:11491] Location: 9:90801787-90898549 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell phagocyte microglia Follicular B cell myeloid cell antigen presenting cell hematopoietic cell dendritic cell macrophage Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System TAP1 Gene Information Basic Information Ensembl ID: ENSG00000168394 Description: transporter 1%2C ATP binding cassette subfamily B member [Source:HGNC Symbol;Acc:HGNC:43] Location: 6:32845209-32853816 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: developing T cell dendritic cell Regulatory T cell CD8+ T cell leukocyte T cell Other: Adaptive Immune System TAP2 Gene Information Basic Information Ensembl ID: ENSG00000204267 Description: transporter 2%2C ATP binding cassette subfamily B member [Source:HGNC Symbol;Acc:HGNC:44] Location: 6:32821833-32838739 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: T cell Other: Adaptive Immune System TAPBP Gene Information Basic Information Ensembl ID: ENSG00000231925 Description: TAP binding protein [Source:HGNC Symbol;Acc:HGNC:11566] Location: 6:33299694-33314284 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell dendritic cell leukocyte secretory cell T cell epithelial cell M cell Other: Adaptive Immune System TLR1 Gene Information Basic Information Ensembl ID: ENSG00000174125 Description: toll like receptor 1 [Source:HGNC Symbol;Acc:HGNC:11847] Location: 4:38787555-38856817 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Adaptive Immune System Innate Immune System Diseases associated with the TLR signaling cascade TLR2 Gene Information Basic Information Ensembl ID: ENSG00000137462 Description: toll like receptor 2 [Source:HGNC Symbol;Acc:HGNC:11848] Location: 4:153684050-153706260 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell macrophage phagocyte microglia granulocyte neutrophil Other: Adaptive Immune System Innate Immune System Diseases associated with the TLR signaling cascade TLR4 Gene Information Basic Information Ensembl ID: ENSG00000136869 Description: toll like receptor 4 [Source:HGNC Symbol;Acc:HGNC:11850] Location: 9:117704175-117724735 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell myeloid cell Other: Apoptosis Adaptive Immune System Innate Immune System TNFRSF14 Gene Information Basic Information Ensembl ID: ENSG00000157873 Description: TNF receptor superfamily member 14 [Source:HGNC Symbol;Acc:HGNC:11912] Location: 1:2555639-2565382 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: CD8+ T cell Regulatory T cell Other: Cytokine Signaling in Immune system Adaptive Immune System TRAT1 Gene Information Basic Information Ensembl ID: ENSG00000163519 Description: T cell receptor associated transmembrane adaptor 1 [Source:HGNC Symbol;Acc:HGNC:30698] Location: 3:108822770-108855005 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell CD8+ T cell developing T cell T cell Specialized T cell CD4+ T cell Other: Adaptive Immune System Intracellular signaling by second messengers PI3K/AKT Signaling in Cancer TREM2 Gene Information Basic Information Ensembl ID: ENSG00000095970 Description: triggering receptor expressed on myeloid cells 2 [Source:HGNC Symbol;Acc:HGNC:17761] Location: 6:41158506-41163186 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron macrophage dendritic cell phagocyte monocyte antigen presenting cell microglia Other: Adaptive Immune System Innate Immune System Nervous system development VCAM1 Gene Information Basic Information Ensembl ID: ENSG00000162692 Description: vascular cell adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:12663] Location: 1:100719742-100739045 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell stromal cell monocyte stem cell fibroblast Specialized T cell epithelial cell dendritic cell macrophage adipocyte mesenchymal stem cell cardiomyocyte Other: Cytokine Signaling in Immune system Adaptive Immune System Integrin cell surface interactions ZAP70 Gene Information Basic Information Ensembl ID: ENSG00000115085 Description: zeta chain of T cell receptor associated protein kinase 70 [Source:HGNC Symbol;Acc:HGNC:12858] Location: 2:97713576-97744327 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell developing T cell T cell CD8+ T cell Specialized T cell Other: Adaptive Immune System Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Signaling by ALK in cancer
Adipogenesis Pathway Hierarchies & Genes Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 (10 genes) Developmental Biology Adipogenesis Transcriptional regulation of white adipocyte differentiation 8 genes Transcriptional regulation of brown and beige adipocyte differentiation Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 2 genes	CCND3 Gene Information Basic Information Ensembl ID: ENSG00000112576 Description: cyclin D3 [Source:HGNC Symbol;Acc:HGNC:1585] Location: 6:41934934-42050357 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell natural killer cell developing T cell epithelial cell CD4+ T cell lymphoid progenitor cell T cell hematopoietic cell Specialized T cell memory T cell lymphocyte megakaryocyte Other: MAPK family signaling cascades Cell Cycle, Mitotic RNA Polymerase II Transcription CDK4 Gene Information Basic Information Ensembl ID: ENSG00000135446 Description: cyclin dependent kinase 4 [Source:HGNC Symbol;Acc:HGNC:1773] Location: 12:57747727-57756013 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: T cell schwann cell progenitor cell neural crest cell Other: Adipogenesis Meiosis Cellular responses to stress CREBBP Gene Information Basic Information Ensembl ID: ENSG00000005339 Description: CREB binding protein [Source:HGNC Symbol;Acc:HGNC:2348] Location: 16:3725054-3880713 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes BMAL1:CLOCK,NPAS2 activates circadian expression HDAC3 Gene Information Basic Information Ensembl ID: ENSG00000171720 Description: histone deacetylase 3 [Source:HGNC Symbol;Acc:HGNC:4854] Location: 5:141620876-141636849 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Death Receptor Signaling Signaling by NOTCH Mitochondrial biogenesis NFKB1 Gene Information Basic Information Ensembl ID: ENSG00000109320 Description: nuclear factor kappa B subunit 1 [Source:HGNC Symbol;Acc:HGNC:7794] Location: 4:102501330-102617302 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System PPARG Gene Information Basic Information Ensembl ID: ENSG00000132170 Description: peroxisome proliferator activated receptor gamma [Source:HGNC Symbol;Acc:HGNC:9236] Location: 3:12287368-12434356 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell pericyte epithelial cell stem cell phagocyte adipocyte macrophage tuft cell Other: Epigenetic regulation of gene expression Metabolism of lipids Post-translational protein modification PPARGC1A Gene Information Basic Information Ensembl ID: ENSG00000109819 Description: PPARG coactivator 1 alpha [Source:HGNC Symbol;Acc:HGNC:9237] Location: 4:23755041-23904089 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Mitochondrial biogenesis Epigenetic regulation of gene expression Cellular responses to stress RELA Gene Information Basic Information Ensembl ID: ENSG00000173039 Description: RELA proto-oncogene%2C NF-kB subunit [Source:HGNC Symbol;Acc:HGNC:9955] Location: 11:65653599-65663090 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System TGFB1 Gene Information Basic Information Ensembl ID: ENSG00000105329 Description: transforming growth factor beta 1 [Source:HGNC Symbol;Acc:HGNC:11766] Location: 19:41301587-41353922 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell developing T cell T cell CD8+ T cell platelet Specialized T cell megakaryocyte Other: Platelet activation, signaling and aggregation RNA Polymerase II Transcription Cytokine Signaling in Immune system TNF Gene Information Basic Information Ensembl ID: ENSG00000232810 Description: tumor necrosis factor [Source:HGNC Symbol;Acc:HGNC:11892] Location: 6:31575565-31578336 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: macrophage CD4+ T cell Specialized T cell neuron T cell dendritic cell Other: Cytokine Signaling in Immune system Death Receptor Signaling Adipogenesis
Apoptosis Pathway Hierarchies & Genes Caspase activation via Dependence Receptors in the absence of ligand (1 genes) Programmed Cell Death Apoptosis Intrinsic Pathway for Apoptosis Apoptotic factor-mediated response Cytochrome c-mediated apoptotic response Activation of caspases through apoptosome-mediated cleavage Apoptotic execution phase Apoptotic cleavage of cellular proteins Caspase-mediated cleavage of cytoskeletal proteins Caspase activation via extrinsic apoptotic signalling pathway Caspase activation via Dependence Receptors in the absence of ligand 1 genes Regulation by c-FLIP (2 genes) Programmed Cell Death Apoptosis Intrinsic Pathway for Apoptosis Activation, myristolyation of BID and translocation to mitochondria Apoptotic execution phase 1 genes Apoptotic cleavage of cellular proteins Caspase-mediated cleavage of cytoskeletal proteins Caspase activation via extrinsic apoptotic signalling pathway Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP 1 genes Regulation of the apoptosome activity (2 genes) Programmed Cell Death Apoptosis Intrinsic Pathway for Apoptosis Apoptotic factor-mediated response Cytochrome c-mediated apoptotic response Formation of apoptosome Regulation of the apoptosome activity 2 genes Activation of BAD and translocation to mitochondria (5 genes) Programmed Cell Death Apoptosis Intrinsic Pathway for Apoptosis Activation of BH3-only proteins Activation of BAD and translocation to mitochondria 5 genes Activation of BIM and translocation to mitochondria (1 genes) Programmed Cell Death Apoptosis Intrinsic Pathway for Apoptosis Activation of BH3-only proteins Activation of BIM and translocation to mitochondria 1 genes Activation of NOXA and translocation to mitochondria (2 genes) Programmed Cell Death Apoptosis Intrinsic Pathway for Apoptosis Activation of BH3-only proteins Activation of NOXA and translocation to mitochondria 2 genes Apoptotic cleavage of cell adhesion proteins (2 genes) Programmed Cell Death Apoptosis Apoptotic execution phase Apoptotic cleavage of cellular proteins Apoptotic cleavage of cell adhesion proteins 2 genes Regulation by c-FLIP (7 genes) Programmed Cell Death Apoptosis Caspase activation via extrinsic apoptotic signalling pathway Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP 7 genes Activation, myristolyation of BID and translocation to mitochondria (1 genes) Programmed Cell Death Apoptosis Intrinsic Pathway for Apoptosis Activation, myristolyation of BID and translocation to mitochondria 1 genes Apoptotic cleavage of cellular proteins (1 genes) Programmed Cell Death Apoptosis Apoptotic execution phase Apoptotic cleavage of cellular proteins 1 genes BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members (2 genes) Programmed Cell Death Apoptosis Intrinsic Pathway for Apoptosis BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 2 genes Caspase activation via Death Receptors in the presence of ligand (3 genes) Programmed Cell Death Apoptosis Caspase activation via extrinsic apoptotic signalling pathway Caspase activation via Death Receptors in the presence of ligand 3 genes	AKT1 Gene Information Basic Information Ensembl ID: ENSG00000142208 Description: AKT serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:391] Location: 14:104769349-104795759 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Integrin signaling Apoptosis Cytokine Signaling in Immune system AKT2 Gene Information Basic Information Ensembl ID: ENSG00000105221 Description: AKT serine/threonine kinase 2 [Source:HGNC Symbol;Acc:HGNC:392] Location: 19:40230317-40285536 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: T cell Other: Apoptosis Cytokine Signaling in Immune system Adaptive Immune System AKT3 Gene Information Basic Information Ensembl ID: ENSG00000117020 Description: AKT serine/threonine kinase 3 [Source:HGNC Symbol;Acc:HGNC:393] Location: 1:243488233-243851079 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell neuron epithelial cell T cell fibroblast glial cell CD8+ T cell schwann cell Specialized T cell excitatory neuron smooth muscle cell Other: Apoptosis Cytokine Signaling in Immune system Adaptive Immune System APC Gene Information Basic Information Ensembl ID: ENSG00000134982 Description: APC regulator of WNT signaling pathway [Source:HGNC Symbol;Acc:HGNC:583] Location: 5:112707518-112846239 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: bergmann glial cell astrocyte bipolar cell Other: Apoptosis Signaling by WNT Post-translational protein modification BCL2 Gene Information Basic Information Ensembl ID: ENSG00000171791 Description: BCL2 apoptosis regulator [Source:HGNC Symbol;Acc:HGNC:990] Location: 18:63123346-63320128 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: cancer cell Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System BCL2L1 Gene Information Basic Information Ensembl ID: ENSG00000171552 Description: BCL2 like 1 [Source:HGNC Symbol;Acc:HGNC:992] Location: 20:31664452-31723989 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System BID Gene Information Basic Information Ensembl ID: ENSG00000015475 Description: BH3 interacting domain death agonist [Source:HGNC Symbol;Acc:HGNC:1050] Location: 22:17734138-17774770 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis RNA Polymerase II Transcription CASP3 Gene Information Basic Information Ensembl ID: ENSG00000164305 Description: caspase 3 [Source:HGNC Symbol;Acc:HGNC:1504] Location: 4:184627696-184650062 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron mast cell innate lymphoid cell progenitor cell stem cell basal cell Other: Apoptosis Cytokine Signaling in Immune system Degradation of the extracellular matrix CASP8 Gene Information Basic Information Ensembl ID: ENSG00000064012 Description: caspase 8 [Source:HGNC Symbol;Acc:HGNC:1509] Location: 2:201233443-201361836 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System CD14 Gene Information Basic Information Ensembl ID: ENSG00000170458 Description: CD14 molecule [Source:HGNC Symbol;Acc:HGNC:1628] Location: 5:140631728-140633700 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell macrophage dendritic cell phagocyte myeloid cell antigen presenting cell monocyte Other: Apoptosis Adaptive Immune System Innate Immune System CDH1 Gene Information Basic Information Ensembl ID: ENSG00000039068 Description: cadherin 1 [Source:HGNC Symbol;Acc:HGNC:1748] Location: 16:68737292-68835537 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: goblet cell epithelial cell pneumocyte stem cell secretory cell tuft cell paneth cell ciliated cell neuroendocrine cell brush cell basal cell serous cell deuterosomal cell club Other: Apoptosis Adaptive Immune System Degradation of the extracellular matrix CTNNB1 Gene Information Basic Information Ensembl ID: ENSG00000168036 Description: catenin beta 1 [Source:HGNC Symbol;Acc:HGNC:2514] Location: 3:41194741-41260096 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell endothelial cell epithelial cell stem cell phagocyte adrenal cortical cell fibroblast monocyte Specialized T cell melanocyte M cell Other: Apoptosis Innate Immune System Signaling by WNT E2F1 Gene Information Basic Information Ensembl ID: ENSG00000101412 Description: E2F transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:3113] Location: 20:33675477-33686385 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Signaling by NOTCH Cellular responses to stress FADD Gene Information Basic Information Ensembl ID: ENSG00000168040 Description: Fas associated via death domain [Source:HGNC Symbol;Acc:HGNC:3573] Location: 11:70203296-70207390 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Innate Immune System Regulated Necrosis FAS Gene Information Basic Information Ensembl ID: ENSG00000026103 Description: Fas cell surface death receptor [Source:HGNC Symbol;Acc:HGNC:11920] Location: 10:88953813-89029605 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: CD4+ T cell Regulatory T cell Other: Apoptosis Regulated Necrosis RNA Polymerase II Transcription FASLG Gene Information Basic Information Ensembl ID: ENSG00000117560 Description: Fas ligand [Source:HGNC Symbol;Acc:HGNC:11936] Location: 1:172659103-172666876 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell T cell Specialized T cell CD8+ T cell Other: Apoptosis Cytokine Signaling in Immune system Regulated Necrosis GZMB Gene Information Basic Information Ensembl ID: ENSG00000100453 Description: granzyme B [Source:HGNC Symbol;Acc:HGNC:4709] Location: 14:24630954-24634267 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: CD8+ T cell T cell innate lymphoid cell natural killer cell developing T cell Other: Apoptosis Signaling by NOTCH Regulated Necrosis MAPK1 Gene Information Basic Information Ensembl ID: ENSG00000100030 Description: mitogen-activated protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:6871] Location: 22:21759657-21867680 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Transmission across Chemical Synapses Signaling by NODAL MAPK3 Gene Information Basic Information Ensembl ID: ENSG00000102882 Description: mitogen-activated protein kinase 3 [Source:HGNC Symbol;Acc:HGNC:6877] Location: 16:30114105-30123506 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Transmission across Chemical Synapses Signaling by NODAL MAPK8 Gene Information Basic Information Ensembl ID: ENSG00000107643 Description: mitogen-activated protein kinase 8 [Source:HGNC Symbol;Acc:HGNC:6881] Location: 10:48306639-48439360 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System STAT3 Gene Information Basic Information Ensembl ID: ENSG00000168610 Description: signal transducer and activator of transcription 3 [Source:HGNC Symbol;Acc:HGNC:11364] Location: 17:42313324-42388568 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: cancer cell Other: Apoptosis Cytokine Signaling in Immune system Cellular responses to stress TICAM1 Gene Information Basic Information Ensembl ID: ENSG00000127666 Description: TIR domain containing adaptor molecule 1 [Source:HGNC Symbol;Acc:HGNC:18348] Location: 19:4815932-4831712 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Innate Immune System Diseases associated with the TLR signaling cascade TLR4 Gene Information Basic Information Ensembl ID: ENSG00000136869 Description: toll like receptor 4 [Source:HGNC Symbol;Acc:HGNC:11850] Location: 9:117704175-117724735 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell myeloid cell Other: Apoptosis Adaptive Immune System Innate Immune System TNFRSF10A Gene Information Basic Information Ensembl ID: ENSG00000104689 Description: TNF receptor superfamily member 10a [Source:HGNC Symbol;Acc:HGNC:11904] Location: 8:23190452-23225102 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Follicular B cell Other: Apoptosis Cell surface interactions at the vascular wall Regulated Necrosis TNFRSF10B Gene Information Basic Information Ensembl ID: ENSG00000120889 Description: TNF receptor superfamily member 10b [Source:HGNC Symbol;Acc:HGNC:11905] Location: 8:23020133-23069031 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Cell surface interactions at the vascular wall Regulated Necrosis TNFSF10 Gene Information Basic Information Ensembl ID: ENSG00000121858 Description: TNF superfamily member 10 [Source:HGNC Symbol;Acc:HGNC:11925] Location: 3:172505508-172523475 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell epithelial cell monocyte mast cell secretory cell Other: Apoptosis Regulated Necrosis Death Receptor Signaling TP53 Gene Information Basic Information Ensembl ID: ENSG00000141510 Description: tumor protein p53 [Source:HGNC Symbol;Acc:HGNC:11998] Location: 17:7661779-7687546 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Cytokine Signaling in Immune system Signaling by NOTCH TRAF2 Gene Information Basic Information Ensembl ID: ENSG00000127191 Description: TNF receptor associated factor 2 [Source:HGNC Symbol;Acc:HGNC:12032] Location: 9:136881912-136929221 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System VIM Gene Information Basic Information Ensembl ID: ENSG00000026025 Description: vimentin [Source:HGNC Symbol;Acc:HGNC:12692] Location: 10:17228241-17237593 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell pericyte macrophage monocyte stem cell embryonic cell phagocyte fibroblast glial cell smooth muscle cell oligodendrocyte precursor cell bone cell mast cell granulocyte antigen presenting cell interstitial cell mesenchymal cell mesenchymal stem cell Other: Apoptosis Cytokine Signaling in Immune system Macroautophagy
BMAL1:CLOCK,NPAS2 activates circadian expression Pathway Hierarchies & Genes BMAL1:CLOCK,NPAS2 activates circadian expression (1 genes) Circadian clock BMAL1:CLOCK,NPAS2 activates circadian expression 1 genes	CREBBP Gene Information Basic Information Ensembl ID: ENSG00000005339 Description: CREB binding protein [Source:HGNC Symbol;Acc:HGNC:2348] Location: 16:3725054-3880713 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes BMAL1:CLOCK,NPAS2 activates circadian expression
Binding and Uptake of Ligands by Scavenger Receptors Pathway Hierarchies & Genes Scavenging by Class A Receptors (1 genes) Vesicle-mediated transport Binding and Uptake of Ligands by Scavenger Receptors Scavenging by Class A Receptors 1 genes Scavenging of heme from plasma (1 genes) Vesicle-mediated transport Binding and Uptake of Ligands by Scavenger Receptors Scavenging of heme from plasma 1 genes	CD163 Gene Information Basic Information Ensembl ID: ENSG00000177575 Description: CD163 molecule [Source:HGNC Symbol;Acc:HGNC:1631] Location: 12:7470811-7503893 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell macrophage phagocyte monocyte myeloid cell antigen presenting cell hematopoietic cell lymphocyte Other: Parasitic Infection Pathways Binding and Uptake of Ligands by Scavenger Receptors MARCO Gene Information Basic Information Ensembl ID: ENSG00000019169 Description: macrophage receptor with collagenous structure [Source:HGNC Symbol;Acc:HGNC:6895] Location: 2:118942194-118994660 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: macrophage phagocyte monocyte antigen presenting cell leukocyte Other: Binding and Uptake of Ligands by Scavenger Receptors
Cardiogenesis Pathway Hierarchies & Genes Cardiogenesis (3 genes) Developmental Biology Cardiogenesis 3 genes	CTNNB1 Gene Information Basic Information Ensembl ID: ENSG00000168036 Description: catenin beta 1 [Source:HGNC Symbol;Acc:HGNC:2514] Location: 3:41194741-41260096 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell endothelial cell epithelial cell stem cell phagocyte adrenal cortical cell fibroblast monocyte Specialized T cell melanocyte M cell Other: Apoptosis Innate Immune System Signaling by WNT EOMES Gene Information Basic Information Ensembl ID: ENSG00000163508 Description: eomesodermin [Source:HGNC Symbol;Acc:HGNC:3372] Location: 3:27715949-27722711 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell Specialized T cell CD8+ T cell T cell progenitor cell mesodermal cell brush cell Other: Transcriptional regulation of pluripotent stem cells Cardiogenesis Gastrulation LEF1 Gene Information Basic Information Ensembl ID: ENSG00000138795 Description: lymphoid enhancer binding factor 1 [Source:HGNC Symbol;Acc:HGNC:6551] Location: 4:108047545-108168956 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell developing T cell T cell Regulatory T cell Naive B cell CD4+ T cell lymphoid progenitor cell innate lymphoid cell Other: Signaling by WNT RNA Polymerase II Transcription Transcriptional regulation of granulopoiesis
Cell Cycle Checkpoints Pathway Hierarchies & Genes G2/M DNA damage checkpoint (2 genes) Cell Cycle Cell Cycle Checkpoints G1/S DNA Damage Checkpoints p53-Dependent G1/S DNA damage checkpoint p53-Dependent G1 DNA Damage Response Stabilization of p53 Autodegradation of the E3 ubiquitin ligase COP1 G2/M Checkpoints G2/M DNA damage checkpoint 2 genes Stabilization of p53 (4 genes) Cell Cycle Cell Cycle Checkpoints G2/M Checkpoints G2/M DNA damage checkpoint Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 2 genes G1/S DNA Damage Checkpoints p53-Dependent G1/S DNA damage checkpoint p53-Dependent G1 DNA Damage Response 1 genes Stabilization of p53 1 genes Transcriptional activation of cell cycle inhibitor p21 (1 genes) Cell Cycle Cell Cycle Checkpoints G1/S DNA Damage Checkpoints p53-Dependent G1/S DNA damage checkpoint p53-Dependent G1 DNA Damage Response Transcriptional activation of p53 responsive genes Transcriptional activation of cell cycle inhibitor p21 1 genes p53-Dependent G1 DNA Damage Response (3 genes) Cell Cycle Cell Cycle Checkpoints G2/M Checkpoints Activation of ATR in response to replication stress 2 genes G1/S DNA Damage Checkpoints p53-Dependent G1/S DNA damage checkpoint p53-Dependent G1 DNA Damage Response 1 genes Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (1 genes) Cell Cycle Cell Cycle Checkpoints Mitotic Spindle Checkpoint Amplification of signal from the kinetochores Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 1 genes p53-Dependent G1 DNA Damage Response (1 genes) Cell Cycle Cell Cycle Checkpoints G1/S DNA Damage Checkpoints p53-Dependent G1/S DNA damage checkpoint p53-Dependent G1 DNA Damage Response 1 genes G2/M DNA damage checkpoint (1 genes) Cell Cycle Cell Cycle Checkpoints G2/M Checkpoints G2/M DNA damage checkpoint 1 genes	ATM Gene Information Basic Information Ensembl ID: ENSG00000149311 Description: ATM serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:795] Location: 11:108222804-108369102 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell T cell phagocyte hematopoietic cell Specialized T cell developing T cell Naive B cell lymphocyte Other: Meiosis Macroautophagy Cellular responses to stress ATR Gene Information Basic Information Ensembl ID: ENSG00000175054 Description: ATR serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:882] Location: 3:142449007-142578733 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Meiosis Cellular responses to stress DNA Double-Strand Break Repair BIRC5 Gene Information Basic Information Ensembl ID: ENSG00000089685 Description: baculoviral IAP repeat containing 5 [Source:HGNC Symbol;Acc:HGNC:593] Location: 17:78214186-78225636 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell glial cell epithelial cell erythroid lineage cell progenitor cell cancer stem cell proliferative cell Other: Cytokine Signaling in Immune system Post-translational protein modification Cell Cycle, Mitotic BRCA1 Gene Information Basic Information Ensembl ID: ENSG00000012048 Description: BRCA1 DNA repair associated [Source:HGNC Symbol;Acc:HGNC:1100] Location: 17:43044295-43170245 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: cancer cell Other: Meiosis Cellular responses to stress DNA Double-Strand Break Repair CCNB1 Gene Information Basic Information Ensembl ID: ENSG00000134057 Description: cyclin B1 [Source:HGNC Symbol;Acc:HGNC:1579] Location: 5:69167135-69178245 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cell Cycle, Mitotic Cell Cycle Checkpoints RNA Polymerase II Transcription CCNE1 Gene Information Basic Information Ensembl ID: ENSG00000105173 Description: cyclin E1 [Source:HGNC Symbol;Acc:HGNC:1589] Location: 19:29811991-29824312 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: trophoblast cell Other: Cellular responses to stress Protein folding Synthesis of DNA CDC25C Gene Information Basic Information Ensembl ID: ENSG00000158402 Description: cell division cycle 25C [Source:HGNC Symbol;Acc:HGNC:1727] Location: 5:138285269-138338355 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cell Cycle, Mitotic Cell Cycle Checkpoints RNA Polymerase II Transcription CDK2 Gene Information Basic Information Ensembl ID: ENSG00000123374 Description: cyclin dependent kinase 2 [Source:HGNC Symbol;Acc:HGNC:1771] Location: 12:55966781-55972789 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Meiosis Cellular responses to stress DNA Double-Strand Break Repair CDKN1A Gene Information Basic Information Ensembl ID: ENSG00000124762 Description: cyclin dependent kinase inhibitor 1A [Source:HGNC Symbol;Acc:HGNC:1784] Location: 6:36676460-36687397 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell pericyte dendritic cell smooth muscle cell fibroblast muscle cell monocyte Other: Cytokine Signaling in Immune system Cellular responses to stress Post-translational protein modification CHEK1 Gene Information Basic Information Ensembl ID: ENSG00000149554 Description: checkpoint kinase 1 [Source:HGNC Symbol;Acc:HGNC:1925] Location: 11:125625163-125676255 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: DNA Double-Strand Break Repair Cell Cycle Checkpoints RNA Polymerase II Transcription CHEK2 Gene Information Basic Information Ensembl ID: ENSG00000183765 Description: checkpoint kinase 2 [Source:HGNC Symbol;Acc:HGNC:16627] Location: 22:28687743-28742422 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: DNA Double-Strand Break Repair Cell Cycle Checkpoints RNA Polymerase II Transcription MCM2 Gene Information Basic Information Ensembl ID: ENSG00000073111 Description: minichromosome maintenance complex component 2 [Source:HGNC Symbol;Acc:HGNC:6944] Location: 3:127598223-127622436 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: DNA Replication Pre-Initiation Synthesis of DNA Cell Cycle, Mitotic TP53 Gene Information Basic Information Ensembl ID: ENSG00000141510 Description: tumor protein p53 [Source:HGNC Symbol;Acc:HGNC:11998] Location: 17:7661779-7687546 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Cytokine Signaling in Immune system Signaling by NOTCH
Cell Cycle, Mitotic Pathway Hierarchies & Genes APC/C:Cdc20 mediated degradation of Cyclin B (1 genes) Cell Cycle Cell Cycle, Mitotic Mitotic G1 phase and G1/S transition G1/S Transition E2F mediated regulation of DNA replication E2F-enabled inhibition of pre-replication complex formation Mitotic G2-G2/M phases G2/M Transition Polo-like kinase mediated events M Phase Mitotic Metaphase and Anaphase Mitotic Anaphase Nuclear Envelope (NE) Reassembly Initiation of Nuclear Envelope (NE) Reformation Regulation of mitotic cell cycle APC/C-mediated degradation of cell cycle proteins Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC/C:Cdc20 mediated degradation of mitotic proteins APC/C:Cdc20 mediated degradation of Cyclin B 1 genes Cyclin A/B1/B2 associated events during G2/M transition (2 genes) Cell Cycle Cell Cycle, Mitotic Mitotic G1 phase and G1/S transition G1/S Transition Cyclin E associated events during G1/S transition Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Regulation of mitotic cell cycle APC/C-mediated degradation of cell cycle proteins Regulation of APC/C activators between G1/S and early anaphase 1 genes S Phase Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic G2-G2/M phases G2/M Transition Cyclin A/B1/B2 associated events during G2/M transition 1 genes Cyclin A:Cdk2-associated events at S phase entry (2 genes) Cell Cycle Cell Cycle, Mitotic Mitotic G1 phase and G1/S transition G1/S Transition E2F mediated regulation of DNA replication Inhibition of replication initiation of damaged DNA by RB1/E2F1 Regulation of mitotic cell cycle APC/C-mediated degradation of cell cycle proteins APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 M Phase 1 genes Mitotic Prophase Condensation of Prophase Chromosomes S Phase Cyclin A:Cdk2-associated events at S phase entry 1 genes Cyclin E associated events during G1/S transition (3 genes) Cell Cycle Cell Cycle, Mitotic S Phase Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic G2-G2/M phases G2/M Transition The role of GTSE1 in G2/M progression after G2 checkpoint Mitotic G1 phase and G1/S transition 2 genes G1/S Transition Cyclin E associated events during G1/S transition 1 genes Cyclin A:Cdk2-associated events at S phase entry (3 genes) Cell Cycle Cell Cycle, Mitotic Mitotic G1 phase and G1/S transition G1/S Transition Cyclin E associated events during G1/S transition S Phase Cyclin A:Cdk2-associated events at S phase entry 3 genes Cyclin A:Cdk2-associated events at S phase entry (1 genes) Cell Cycle Cell Cycle, Mitotic Mitotic G1 phase and G1/S transition G0 and Early G1 Transcription of E2F targets under negative control by DREAM complex S Phase Cyclin A:Cdk2-associated events at S phase entry 1 genes Depolymerization of the Nuclear Lamina (1 genes) Cell Cycle Cell Cycle, Mitotic M Phase Mitotic Prophase Nuclear Envelope Breakdown Depolymerization of the Nuclear Lamina 1 genes Drug-mediated inhibition of CDK4/CDK6 activity (2 genes) Cell Cycle Cell Cycle, Mitotic Mitotic G1 phase and G1/S transition G1 Phase Cyclin D associated events in G1 Drug-mediated inhibition of CDK4/CDK6 activity 2 genes Separation of Sister Chromatids (1 genes) Cell Cycle Cell Cycle, Mitotic M Phase Mitotic Metaphase and Anaphase Mitotic Anaphase Separation of Sister Chromatids 1 genes Cyclin D associated events in G1 (3 genes) Cell Cycle Cell Cycle, Mitotic Mitotic G1 phase and G1/S transition G1 Phase Cyclin D associated events in G1 3 genes Golgi Cisternae Pericentriolar Stack Reorganization (2 genes) Cell Cycle Cell Cycle, Mitotic M Phase Mitotic Prophase Golgi Cisternae Pericentriolar Stack Reorganization 2 genes Polo-like kinase mediated events (1 genes) Cell Cycle Cell Cycle, Mitotic Mitotic G2-G2/M phases G2/M Transition Polo-like kinase mediated events 1 genes S Phase (1 genes) Cell Cycle Cell Cycle, Mitotic Mitotic G1 phase and G1/S transition G1/S Transition S Phase 1 genes The role of GTSE1 in G2/M progression after G2 checkpoint (1 genes) Cell Cycle Cell Cycle, Mitotic Mitotic G2-G2/M phases G2/M Transition The role of GTSE1 in G2/M progression after G2 checkpoint 1 genes	ABL1 Gene Information Basic Information Ensembl ID: ENSG00000097007 Description: ABL proto-oncogene 1%2C non-receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:76] Location: 9:130713043-130887675 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Innate Immune System Epigenetic regulation of gene expression Myogenesis AKT1 Gene Information Basic Information Ensembl ID: ENSG00000142208 Description: AKT serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:391] Location: 14:104769349-104795759 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Integrin signaling Apoptosis Cytokine Signaling in Immune system AKT2 Gene Information Basic Information Ensembl ID: ENSG00000105221 Description: AKT serine/threonine kinase 2 [Source:HGNC Symbol;Acc:HGNC:392] Location: 19:40230317-40285536 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: T cell Other: Apoptosis Cytokine Signaling in Immune system Adaptive Immune System AKT3 Gene Information Basic Information Ensembl ID: ENSG00000117020 Description: AKT serine/threonine kinase 3 [Source:HGNC Symbol;Acc:HGNC:393] Location: 1:243488233-243851079 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell neuron epithelial cell T cell fibroblast glial cell CD8+ T cell schwann cell Specialized T cell excitatory neuron smooth muscle cell Other: Apoptosis Cytokine Signaling in Immune system Adaptive Immune System BIRC5 Gene Information Basic Information Ensembl ID: ENSG00000089685 Description: baculoviral IAP repeat containing 5 [Source:HGNC Symbol;Acc:HGNC:593] Location: 17:78214186-78225636 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell glial cell epithelial cell erythroid lineage cell progenitor cell cancer stem cell proliferative cell Other: Cytokine Signaling in Immune system Post-translational protein modification Cell Cycle, Mitotic CCNB1 Gene Information Basic Information Ensembl ID: ENSG00000134057 Description: cyclin B1 [Source:HGNC Symbol;Acc:HGNC:1579] Location: 5:69167135-69178245 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cell Cycle, Mitotic Cell Cycle Checkpoints RNA Polymerase II Transcription CCND1 Gene Information Basic Information Ensembl ID: ENSG00000110092 Description: cyclin D1 [Source:HGNC Symbol;Acc:HGNC:1582] Location: 11:69641156-69654474 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell endothelial cell pericyte monocyte fibroblast glial cell dendritic cell pancreatic cell M cell oligodendrocyte Other: Cytokine Signaling in Immune system Signaling by NOTCH Chromatin modifying enzymes CCND3 Gene Information Basic Information Ensembl ID: ENSG00000112576 Description: cyclin D3 [Source:HGNC Symbol;Acc:HGNC:1585] Location: 6:41934934-42050357 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell natural killer cell developing T cell epithelial cell CD4+ T cell lymphoid progenitor cell T cell hematopoietic cell Specialized T cell memory T cell lymphocyte megakaryocyte Other: MAPK family signaling cascades Cell Cycle, Mitotic RNA Polymerase II Transcription CCNE1 Gene Information Basic Information Ensembl ID: ENSG00000105173 Description: cyclin E1 [Source:HGNC Symbol;Acc:HGNC:1589] Location: 19:29811991-29824312 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: trophoblast cell Other: Cellular responses to stress Protein folding Synthesis of DNA CDC25C Gene Information Basic Information Ensembl ID: ENSG00000158402 Description: cell division cycle 25C [Source:HGNC Symbol;Acc:HGNC:1727] Location: 5:138285269-138338355 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cell Cycle, Mitotic Cell Cycle Checkpoints RNA Polymerase II Transcription CDK2 Gene Information Basic Information Ensembl ID: ENSG00000123374 Description: cyclin dependent kinase 2 [Source:HGNC Symbol;Acc:HGNC:1771] Location: 12:55966781-55972789 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Meiosis Cellular responses to stress DNA Double-Strand Break Repair CDK4 Gene Information Basic Information Ensembl ID: ENSG00000135446 Description: cyclin dependent kinase 4 [Source:HGNC Symbol;Acc:HGNC:1773] Location: 12:57747727-57756013 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: T cell schwann cell progenitor cell neural crest cell Other: Adipogenesis Meiosis Cellular responses to stress CDK6 Gene Information Basic Information Ensembl ID: ENSG00000105810 Description: cyclin dependent kinase 6 [Source:HGNC Symbol;Acc:HGNC:1777] Location: 7:92604921-92836573 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell skeletal muscle cell hematopoietic stem cell fibroblast lymphoid progenitor cell progenitor cell mesangial cell megakaryocyte hematopoietic progenitor cell Other: Cellular responses to stress Cell Cycle, Mitotic RNA Polymerase II Transcription CDKN1A Gene Information Basic Information Ensembl ID: ENSG00000124762 Description: cyclin dependent kinase inhibitor 1A [Source:HGNC Symbol;Acc:HGNC:1784] Location: 6:36676460-36687397 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell pericyte dendritic cell smooth muscle cell fibroblast muscle cell monocyte Other: Cytokine Signaling in Immune system Cellular responses to stress Post-translational protein modification E2F1 Gene Information Basic Information Ensembl ID: ENSG00000101412 Description: E2F transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:3113] Location: 20:33675477-33686385 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Signaling by NOTCH Cellular responses to stress JAK2 Gene Information Basic Information Ensembl ID: ENSG00000096968 Description: Janus kinase 2 [Source:HGNC Symbol;Acc:HGNC:6192] Location: 9:4984390-5129948 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: fibroblast basophil dendritic cell Other: Chromatin modifying enzymes Cytokine Signaling in Immune system Signaling by Leptin LYN Gene Information Basic Information Ensembl ID: ENSG00000254087 Description: LYN proto-oncogene%2C Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6735] Location: 8:55879835-56014169 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System MAPK1 Gene Information Basic Information Ensembl ID: ENSG00000100030 Description: mitogen-activated protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:6871] Location: 22:21759657-21867680 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Transmission across Chemical Synapses Signaling by NODAL MAPK3 Gene Information Basic Information Ensembl ID: ENSG00000102882 Description: mitogen-activated protein kinase 3 [Source:HGNC Symbol;Acc:HGNC:6877] Location: 16:30114105-30123506 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Transmission across Chemical Synapses Signaling by NODAL MCM2 Gene Information Basic Information Ensembl ID: ENSG00000073111 Description: minichromosome maintenance complex component 2 [Source:HGNC Symbol;Acc:HGNC:6944] Location: 3:127598223-127622436 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: DNA Replication Pre-Initiation Synthesis of DNA Cell Cycle, Mitotic MYC Gene Information Basic Information Ensembl ID: ENSG00000136997 Description: MYC proto-oncogene%2C bHLH transcription factor [Source:HGNC Symbol;Acc:HGNC:7553] Location: 8:127735434-127742951 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte epithelial cell fibroblast stromal cell smooth muscle cell hematopoietic progenitor cell endothelial cell stem cell erythroblast muscle cell progenitor cell transient amplifying cell cancer stem cell B cell erythroid lineage cell Other: Cytokine Signaling in Immune system Signaling by NOTCH Signaling by WNT PRKCA Gene Information Basic Information Ensembl ID: ENSG00000154229 Description: protein kinase C alpha [Source:HGNC Symbol;Acc:HGNC:9393] Location: 17:66302613-66810743 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: bipolar cell Other: Transmission across Chemical Synapses Integration of energy metabolism Signaling by WNT RB1 Gene Information Basic Information Ensembl ID: ENSG00000139687 Description: RB transcriptional corepressor 1 [Source:HGNC Symbol;Acc:HGNC:9884] Location: 13:48303744-48599436 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell endothelial cell microglia neuron Other: Epigenetic regulation of gene expression Cellular responses to stress Cell junction organization TP53 Gene Information Basic Information Ensembl ID: ENSG00000141510 Description: tumor protein p53 [Source:HGNC Symbol;Acc:HGNC:11998] Location: 17:7661779-7687546 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Cytokine Signaling in Immune system Signaling by NOTCH
Cell junction organization Pathway Hierarchies & Genes Degradation of CDH1 (2 genes) Cell-Cell communication Cell junction organization Cell-cell junction organization Adherens junctions interactions Regulation of Homotypic Cell-Cell Adhesion Regulation of Expression and Function of Type I Classical Cadherins Regulation of CDH1 Expression and Function Regulation of CDH1 Function Degradation of CDH1 2 genes Negative Regulation of CDH1 Gene Transcription (7 genes) Cell-Cell communication Cell junction organization Cell-cell junction organization Adherens junctions interactions Regulation of Homotypic Cell-Cell Adhesion Regulation of Expression and Function of Type I Classical Cadherins Regulation of CDH1 Expression and Function Regulation of CDH1 Gene Transcription Negative Regulation of CDH1 Gene Transcription 7 genes Positive Regulation of CDH1 Gene Transcription (1 genes) Cell-Cell communication Cell junction organization Cell-cell junction organization Adherens junctions interactions Regulation of Homotypic Cell-Cell Adhesion Regulation of Expression and Function of Type I Classical Cadherins Regulation of CDH1 Expression and Function Regulation of CDH1 Gene Transcription Positive Regulation of CDH1 Gene Transcription 1 genes Regulation of CDH1 mRNA translation by microRNAs (2 genes) Cell-Cell communication Cell junction organization Cell-cell junction organization Adherens junctions interactions Regulation of Homotypic Cell-Cell Adhesion Regulation of Expression and Function of Type I Classical Cadherins Regulation of CDH1 Expression and Function Regulation of CDH1 mRNA translation by microRNAs 2 genes Nectin/Necl trans heterodimerization (1 genes) Cell-Cell communication Cell junction organization Cell-cell junction organization Adherens junctions interactions Nectin/Necl trans heterodimerization 1 genes Adherens junctions interactions (1 genes) Cell-Cell communication Cell junction organization Cell-cell junction organization Adherens junctions interactions 1 genes Localization of the PINCH-ILK-PARVIN complex to focal adhesions (1 genes) Cell-Cell communication Cell junction organization Cell-extracellular matrix interactions Localization of the PINCH-ILK-PARVIN complex to focal adhesions 1 genes Type I hemidesmosome assembly (4 genes) Cell-Cell communication Cell junction organization Type I hemidesmosome assembly 4 genes	CDH1 Gene Information Basic Information Ensembl ID: ENSG00000039068 Description: cadherin 1 [Source:HGNC Symbol;Acc:HGNC:1748] Location: 16:68737292-68835537 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: goblet cell epithelial cell pneumocyte stem cell secretory cell tuft cell paneth cell ciliated cell neuroendocrine cell brush cell basal cell serous cell deuterosomal cell club Other: Apoptosis Adaptive Immune System Degradation of the extracellular matrix CDH5 Gene Information Basic Information Ensembl ID: ENSG00000179776 Description: cadherin 5 [Source:HGNC Symbol;Acc:HGNC:1764] Location: 16:66366690-66404784 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell neuron cardiomyocyte Other: Cell junction organization Signaling by Receptor Tyrosine Kinases Cellular responses to mechanical stimuli CTNNB1 Gene Information Basic Information Ensembl ID: ENSG00000168036 Description: catenin beta 1 [Source:HGNC Symbol;Acc:HGNC:2514] Location: 3:41194741-41260096 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell endothelial cell epithelial cell stem cell phagocyte adrenal cortical cell fibroblast monocyte Specialized T cell melanocyte M cell Other: Apoptosis Innate Immune System Signaling by WNT EZH2 Gene Information Basic Information Ensembl ID: ENSG00000106462 Description: enhancer of zeste 2 polycomb repressive complex 2 subunit [Source:HGNC Symbol;Acc:HGNC:3527] Location: 7:148807257-148884321 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell Other: Epigenetic regulation of gene expression Cellular responses to stress Chromatin modifying enzymes FYN Gene Information Basic Information Ensembl ID: ENSG00000010810 Description: FYN proto-oncogene%2C Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:4037] Location: 6:111660332-111873452 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Cellular responses to mechanical stimuli ITGA6 Gene Information Basic Information Ensembl ID: ENSG00000091409 Description: integrin subunit alpha 6 [Source:HGNC Symbol;Acc:HGNC:6142] Location: 2:172234216-172506459 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell goblet cell kidney cell pericyte epithelial cell embryonic cell stem cell glial cell stromal cell Other: Collagen formation Cell surface interactions at the vascular wall Integrin cell surface interactions ITGB1 Gene Information Basic Information Ensembl ID: ENSG00000150093 Description: integrin subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:6153] Location: 10:32887273-33005792 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stellate cell pericyte trophoblast cell epithelial cell stromal cell stem cell endothelial cell smooth muscle cell fibroblast mesenchymal stem cell Other: Laminin interactions Cell surface interactions at the vascular wall Cytokine Signaling in Immune system ITGB4 Gene Information Basic Information Ensembl ID: ENSG00000132470 Description: integrin subunit beta 4 [Source:HGNC Symbol;Acc:HGNC:6158] Location: 17:75721328-75757818 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron epithelial cell schwann cell astrocyte dendritic cell M cell endothelial cell Other: Collagen formation Laminin interactions Non-integrin membrane-ECM interactions LAMB3 Gene Information Basic Information Ensembl ID: ENSG00000196878 Description: laminin subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:6490] Location: 1:209614870-209652425 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell stem cell pancreatic cell goblet cell M cell Other: Degradation of the extracellular matrix Collagen formation Laminin interactions LAMC2 Gene Information Basic Information Ensembl ID: ENSG00000058085 Description: laminin subunit gamma 2 [Source:HGNC Symbol;Acc:HGNC:6493] Location: 1:183186238-183245127 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell pancreatic cell goblet cell M cell stem cell Other: Degradation of the extracellular matrix Collagen formation Laminin interactions MAPK1 Gene Information Basic Information Ensembl ID: ENSG00000100030 Description: mitogen-activated protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:6871] Location: 22:21759657-21867680 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Transmission across Chemical Synapses Signaling by NODAL MAPK3 Gene Information Basic Information Ensembl ID: ENSG00000102882 Description: mitogen-activated protein kinase 3 [Source:HGNC Symbol;Acc:HGNC:6877] Location: 16:30114105-30123506 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Transmission across Chemical Synapses Signaling by NODAL MYC Gene Information Basic Information Ensembl ID: ENSG00000136997 Description: MYC proto-oncogene%2C bHLH transcription factor [Source:HGNC Symbol;Acc:HGNC:7553] Location: 8:127735434-127742951 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte epithelial cell fibroblast stromal cell smooth muscle cell hematopoietic progenitor cell endothelial cell stem cell erythroblast muscle cell progenitor cell transient amplifying cell cancer stem cell B cell erythroid lineage cell Other: Cytokine Signaling in Immune system Signaling by NOTCH Signaling by WNT MYCN Gene Information Basic Information Ensembl ID: ENSG00000134323 Description: MYCN proto-oncogene%2C bHLH transcription factor [Source:HGNC Symbol;Acc:HGNC:7559] Location: 2:15940550-15947007 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell Other: Cell junction organization Signaling by Receptor Tyrosine Kinases Signaling by TGFB family members PVR Gene Information Basic Information Ensembl ID: ENSG00000073008 Description: PVR cell adhesion molecule [Source:HGNC Symbol;Acc:HGNC:9705] Location: 19:44643798-44666162 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Adaptive Immune System Cell junction organization RB1 Gene Information Basic Information Ensembl ID: ENSG00000139687 Description: RB transcriptional corepressor 1 [Source:HGNC Symbol;Acc:HGNC:9884] Location: 13:48303744-48599436 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell endothelial cell microglia neuron Other: Epigenetic regulation of gene expression Cellular responses to stress Cell junction organization SMARCA4 Gene Information Basic Information Ensembl ID: ENSG00000127616 Description: SWI/SNF related%2C matrix associated%2C actin dependent regulator of chromatin%2C subfamily a%2C member 4 [Source:HGNC Symbol;Acc:HGNC:11100] Location: 19:10960932-11079426 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell epithelial cell fibroblast Other: Cytokine Signaling in Immune system Signaling by WNT Epigenetic regulation of gene expression TWIST1 Gene Information Basic Information Ensembl ID: ENSG00000122691 Description: twist family bHLH transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:12428] Location: 7:19020991-19117636 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte embryonic cell fibroblast stromal cell epithelial cell mesenchymal cell Other: Cytokine Signaling in Immune system Cell junction organization RNA Polymerase II Transcription WT1 Gene Information Basic Information Ensembl ID: ENSG00000184937 Description: WT1 transcription factor [Source:HGNC Symbol;Acc:HGNC:12796] Location: 11:32387775-32435564 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell stromal cell podocyte mesothelial cell Other: Cell junction organization Transcriptional regulation of testis differentiation Kidney development
Cell surface interactions at the vascular wall Pathway Hierarchies & Genes Tie2 Signaling (40 genes) Hemostasis Cell surface interactions at the vascular wall 24 genes PECAM1 interactions 15 genes Tie2 Signaling 1 genes	ANGPT1 Gene Information Basic Information Ensembl ID: ENSG00000154188 Description: angiopoietin 1 [Source:HGNC Symbol;Acc:HGNC:484] Location: 8:107249482-107498055 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: fibroblast pericyte stromal cell smooth muscle cell epithelial cell megakaryocyte Other: MAPK family signaling cascades Cell surface interactions at the vascular wall CD2 Gene Information Basic Information Ensembl ID: ENSG00000116824 Description: CD2 molecule [Source:HGNC Symbol;Acc:HGNC:1639] Location: 1:116754430-116769229 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell CD8+ T cell developing T cell T cell Other: Cell surface interactions at the vascular wall CD244 Gene Information Basic Information Ensembl ID: ENSG00000122223 Description: CD244 molecule [Source:HGNC Symbol;Acc:HGNC:18171] Location: 1:160830160-160862887 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Specialized T cell natural killer cell CD8+ T cell Other: Cell surface interactions at the vascular wall CD47 Gene Information Basic Information Ensembl ID: ENSG00000196776 Description: CD47 molecule [Source:HGNC Symbol;Acc:HGNC:1682] Location: 3:108043091-108091862 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell pericyte epithelial cell T cell memory T cell endothelial cell megakaryocyte Other: Innate Immune System Cell surface interactions at the vascular wall Integrin cell surface interactions CD48 Gene Information Basic Information Ensembl ID: ENSG00000117091 Description: CD48 molecule [Source:HGNC Symbol;Acc:HGNC:1683] Location: 1:160678746-160711831 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell CD8+ T cell developing T cell leukocyte T cell monocyte Naive B cell lymphocyte Regulatory T cell Other: Cell surface interactions at the vascular wall CD74 Gene Information Basic Information Ensembl ID: ENSG00000019582 Description: CD74 molecule [Source:HGNC Symbol;Acc:HGNC:1697] Location: 5:150401637-150412969 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell dendritic cell macrophage monocyte phagocyte Follicular B cell glial cell microglia Other: Adaptive Immune System Cell surface interactions at the vascular wall Developmental Cell Lineages CD84 Gene Information Basic Information Ensembl ID: ENSG00000066294 Description: CD84 molecule [Source:HGNC Symbol;Acc:HGNC:1704] Location: 1:160541095-160579516 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: macrophage phagocyte monocyte leukocyte mast cell antigen presenting cell memory T cell osteoclast megakaryocyte dendritic cell Other: Cell surface interactions at the vascular wall CEACAM1 Gene Information Basic Information Ensembl ID: ENSG00000079385 Description: CEA cell adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:1814] Location: 19:42507304-42561234 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell epithelial cell stem cell myeloid cell secretory cell neutrophil trophoblast cell Other: Fibronectin matrix formation Innate Immune System Cell surface interactions at the vascular wall EPCAM Gene Information Basic Information Ensembl ID: ENSG00000119888 Description: epithelial cell adhesion molecule [Source:HGNC Symbol;Acc:HGNC:11529] Location: 2:47345158-47387601 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron endocrine cell epithelial cell tuft cell enterocyte fibroblast secretory cell keratinocyte hepatocyte cancer cell Other: Cell surface interactions at the vascular wall Developmental Cell Lineages Bacterial Infection Pathways FN1 Gene Information Basic Information Ensembl ID: ENSG00000115414 Description: fibronectin 1 [Source:HGNC Symbol;Acc:HGNC:3778] Location: 2:215360440-215436073 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell fibroblast endocrine cell pericyte epithelial cell stellate cell stem cell phagocyte muscle cell stromal cell smooth muscle cell thymic epithelial cell skeletal muscle cell mesenchymal cell Other: Cytokine Signaling in Immune system Degradation of the extracellular matrix Elastic fibre formation FYN Gene Information Basic Information Ensembl ID: ENSG00000010810 Description: FYN proto-oncogene%2C Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:4037] Location: 6:111660332-111873452 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Cellular responses to mechanical stimuli HRAS Gene Information Basic Information Ensembl ID: ENSG00000174775 Description: HRas proto-oncogene%2C GTPase [Source:HGNC Symbol;Acc:HGNC:5173] Location: 11:532242-537321 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Transmission across Chemical Synapses Cytokine Signaling in Immune system Adaptive Immune System ITGA4 Gene Information Basic Information Ensembl ID: ENSG00000115232 Description: integrin subunit alpha 4 [Source:HGNC Symbol;Acc:HGNC:6140] Location: 2:181457202-181538940 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell developing T cell Naive B cell Specialized T cell mast cell lymphoid progenitor cell CD8+ T cell erythroid lineage cell T cell memory T cell progenitor cell erythroblast projection neuron Other: Cell surface interactions at the vascular wall Integrin cell surface interactions Adaptive Immune System ITGA5 Gene Information Basic Information Ensembl ID: ENSG00000161638 Description: integrin subunit alpha 5 [Source:HGNC Symbol;Acc:HGNC:6141] Location: 12:54395261-54419266 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell epithelial cell stromal cell smooth muscle cell trophoblast cell mesenchymal stem cell fibroblast Other: Elastic fibre formation Fibronectin matrix formation Cell surface interactions at the vascular wall ITGA6 Gene Information Basic Information Ensembl ID: ENSG00000091409 Description: integrin subunit alpha 6 [Source:HGNC Symbol;Acc:HGNC:6142] Location: 2:172234216-172506459 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell goblet cell kidney cell pericyte epithelial cell embryonic cell stem cell glial cell stromal cell Other: Collagen formation Cell surface interactions at the vascular wall Integrin cell surface interactions ITGAL Gene Information Basic Information Ensembl ID: ENSG00000005844 Description: integrin subunit alpha L [Source:HGNC Symbol;Acc:HGNC:6148] Location: 16:30472658-30523567 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell developing T cell T cell Specialized T cell CD4+ T cell lymphoid progenitor cell CD8+ T cell natural killer cell innate lymphoid cell leukocyte monocyte Other: Adaptive Immune System Innate Immune System Cell surface interactions at the vascular wall ITGAM Gene Information Basic Information Ensembl ID: ENSG00000169896 Description: integrin subunit alpha M [Source:HGNC Symbol;Acc:HGNC:6149] Location: 16:31259967-31332892 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: granulocyte hematopoietic cell dendritic cell myeloid derived suppressor cell monocyte eosinophil neutrophil Other: Cytokine Signaling in Immune system Innate Immune System Cell surface interactions at the vascular wall ITGAV Gene Information Basic Information Ensembl ID: ENSG00000138448 Description: integrin subunit alpha V [Source:HGNC Symbol;Acc:HGNC:6150] Location: 2:186590010-186680901 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell glial cell stromal cell M cell endothelial cell Other: Adaptive Immune System Elastic fibre formation Innate Immune System ITGAX Gene Information Basic Information Ensembl ID: ENSG00000140678 Description: integrin subunit alpha X [Source:HGNC Symbol;Acc:HGNC:6152] Location: 16:31355134-31382999 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell natural killer cell phagocyte mast cell monocyte granulocyte dendritic cell Other: Cytokine Signaling in Immune system Innate Immune System Cell surface interactions at the vascular wall ITGB1 Gene Information Basic Information Ensembl ID: ENSG00000150093 Description: integrin subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:6153] Location: 10:32887273-33005792 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stellate cell pericyte trophoblast cell epithelial cell stromal cell stem cell endothelial cell smooth muscle cell fibroblast mesenchymal stem cell Other: Laminin interactions Cell surface interactions at the vascular wall Cytokine Signaling in Immune system ITGB2 Gene Information Basic Information Ensembl ID: ENSG00000160255 Description: integrin subunit beta 2 [Source:HGNC Symbol;Acc:HGNC:6155] Location: 21:44885953-44931989 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell natural killer cell memory T cell developing T cell macrophage dendritic cell phagocyte leukocyte T cell Specialized T cell monocyte Other: Adaptive Immune System Cytokine Signaling in Immune system Innate Immune System ITGB3 Gene Information Basic Information Ensembl ID: ENSG00000259207 Description: integrin subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:6156] Location: 17:47253827-47313743 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: platelet epithelial cell monocyte Other: ECM proteoglycans Elastic fibre formation Cell surface interactions at the vascular wall KRAS Gene Information Basic Information Ensembl ID: ENSG00000133703 Description: KRAS proto-oncogene%2C GTPase [Source:HGNC Symbol;Acc:HGNC:6407] Location: 12:25205246-25250936 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Signaling by Non-Receptor Tyrosine Kinases Transmission across Chemical Synapses Cytokine Signaling in Immune system LCK Gene Information Basic Information Ensembl ID: ENSG00000182866 Description: LCK proto-oncogene%2C Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6524] Location: 1:32251244-32286165 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell CD8+ T cell developing T cell T cell lymphocyte Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System LYN Gene Information Basic Information Ensembl ID: ENSG00000254087 Description: LYN proto-oncogene%2C Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6735] Location: 8:55879835-56014169 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System MERTK Gene Information Basic Information Ensembl ID: ENSG00000153208 Description: MER proto-oncogene%2C tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:7027] Location: 2:111898607-112029561 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: macrophage phagocyte monocyte microglia myeloid cell antigen presenting cell Other: Cell surface interactions at the vascular wall NRAS Gene Information Basic Information Ensembl ID: ENSG00000213281 Description: NRAS proto-oncogene%2C GTPase [Source:HGNC Symbol;Acc:HGNC:7989] Location: 1:114704469-114716771 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell cancer cell Other: Signaling by Erythropoietin Signaling by Non-Receptor Tyrosine Kinases Signaling by Nuclear Receptors PECAM1 Gene Information Basic Information Ensembl ID: ENSG00000261371 Description: platelet and endothelial cell adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:8823] Location: 17:64319415-64413776 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell neuron fibroblast monocyte pericyte smooth muscle cell endocrine cell epithelial cell platelet immune cell stromal cell hematopoietic stem cell lymphocyte mesenchymal stem cell endocardial cell Other: Innate Immune System Cell surface interactions at the vascular wall Integrin cell surface interactions PIK3CA Gene Information Basic Information Ensembl ID: ENSG00000121879 Description: phosphatidylinositol-4%2C5-bisphosphate 3-kinase catalytic subunit alpha [Source:HGNC Symbol;Acc:HGNC:8975] Location: 3:179148114-179240093 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System PTPN11 Gene Information Basic Information Ensembl ID: ENSG00000179295 Description: protein tyrosine phosphatase non-receptor type 11 [Source:HGNC Symbol;Acc:HGNC:9644] Location: 12:112418351-112509918 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System SELE Gene Information Basic Information Ensembl ID: ENSG00000007908 Description: selectin E [Source:HGNC Symbol;Acc:HGNC:10718] Location: 1:169722640-169764705 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell Other: Cell surface interactions at the vascular wall SELL Gene Information Basic Information Ensembl ID: ENSG00000188404 Description: selectin L [Source:HGNC Symbol;Acc:HGNC:10720] Location: 1:169690665-169711702 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell memory T cell Regulatory T cell Naive B cell T cell dendritic cell lymphoid progenitor cell granulocyte Follicular B cell antigen presenting cell memory B cell monocyte innate lymphoid cell developing T cell neutrophil Other: Adaptive Immune System Innate Immune System Cell surface interactions at the vascular wall SELPLG Gene Information Basic Information Ensembl ID: ENSG00000110876 Description: selectin P ligand [Source:HGNC Symbol;Acc:HGNC:10722] Location: 12:108620413-108633894 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell dendritic cell CD4+ T cell T cell antigen presenting cell Specialized T cell natural killer cell excitatory neuron Other: Cell surface interactions at the vascular wall SPN Gene Information Basic Information Ensembl ID: ENSG00000197471 Description: sialophorin [Source:HGNC Symbol;Acc:HGNC:11249] Location: 16:29662979-29670876 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell Specialized T cell monocyte granulocyte T cell antigen presenting cell innate lymphoid cell lymphocyte erythroblast Other: Cell surface interactions at the vascular wall TEK Gene Information Basic Information Ensembl ID: ENSG00000120156 Description: TEK receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:11724] Location: 9:27109141-27230174 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell Other: Cell surface interactions at the vascular wall MAPK family signaling cascades TGFB1 Gene Information Basic Information Ensembl ID: ENSG00000105329 Description: transforming growth factor beta 1 [Source:HGNC Symbol;Acc:HGNC:11766] Location: 19:41301587-41353922 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell developing T cell T cell CD8+ T cell platelet Specialized T cell megakaryocyte Other: Platelet activation, signaling and aggregation RNA Polymerase II Transcription Cytokine Signaling in Immune system THBD Gene Information Basic Information Ensembl ID: ENSG00000178726 Description: thrombomodulin [Source:HGNC Symbol;Acc:HGNC:11784] Location: 20:23045633-23049672 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell monocyte dendritic cell Other: Formation of Fibrin Clot (Clotting Cascade) Cell surface interactions at the vascular wall TNFRSF10A Gene Information Basic Information Ensembl ID: ENSG00000104689 Description: TNF receptor superfamily member 10a [Source:HGNC Symbol;Acc:HGNC:11904] Location: 8:23190452-23225102 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Follicular B cell Other: Apoptosis Cell surface interactions at the vascular wall Regulated Necrosis TNFRSF10B Gene Information Basic Information Ensembl ID: ENSG00000120889 Description: TNF receptor superfamily member 10b [Source:HGNC Symbol;Acc:HGNC:11905] Location: 8:23020133-23069031 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Cell surface interactions at the vascular wall Regulated Necrosis TNFRSF10D Gene Information Basic Information Ensembl ID: ENSG00000173530 Description: TNF receptor superfamily member 10d [Source:HGNC Symbol;Acc:HGNC:11907] Location: 8:23135588-23164027 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell dendritic cell Other: Cell surface interactions at the vascular wall RNA Polymerase II Transcription Death Receptor Signaling
Cellular responses to mechanical stimuli Pathway Hierarchies & Genes Mechanical load activates signaling by PIEZO1 and integrins in osteocytes (9 genes) Cellular responses to stimuli Cellular responses to mechanical stimuli Response of endothelial cells to shear stress High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells 8 genes Mechanical load activates signaling by PIEZO1 and integrins in osteocytes 1 genes Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (4 genes) Cellular responses to stimuli Cellular responses to mechanical stimuli Mechanical load activates signaling by PIEZO1 and integrins in osteocytes Response of endothelial cells to shear stress Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells 4 genes Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (8 genes) Cellular responses to stimuli Cellular responses to mechanical stimuli Response of endothelial cells to shear stress Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells 8 genes	ABL1 Gene Information Basic Information Ensembl ID: ENSG00000097007 Description: ABL proto-oncogene 1%2C non-receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:76] Location: 9:130713043-130887675 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Innate Immune System Epigenetic regulation of gene expression Myogenesis AKT1 Gene Information Basic Information Ensembl ID: ENSG00000142208 Description: AKT serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:391] Location: 14:104769349-104795759 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Integrin signaling Apoptosis Cytokine Signaling in Immune system CDH5 Gene Information Basic Information Ensembl ID: ENSG00000179776 Description: cadherin 5 [Source:HGNC Symbol;Acc:HGNC:1764] Location: 16:66366690-66404784 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell neuron cardiomyocyte Other: Cell junction organization Signaling by Receptor Tyrosine Kinases Cellular responses to mechanical stimuli CHUK Gene Information Basic Information Ensembl ID: ENSG00000213341 Description: component of inhibitor of nuclear factor kappa B kinase complex [Source:HGNC Symbol;Acc:HGNC:1974] Location: 10:100188300-100229596 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Intracellular signaling by second messengers Cytokine Signaling in Immune system Adaptive Immune System CTNNB1 Gene Information Basic Information Ensembl ID: ENSG00000168036 Description: catenin beta 1 [Source:HGNC Symbol;Acc:HGNC:2514] Location: 3:41194741-41260096 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell endothelial cell epithelial cell stem cell phagocyte adrenal cortical cell fibroblast monocyte Specialized T cell melanocyte M cell Other: Apoptosis Innate Immune System Signaling by WNT FN1 Gene Information Basic Information Ensembl ID: ENSG00000115414 Description: fibronectin 1 [Source:HGNC Symbol;Acc:HGNC:3778] Location: 2:215360440-215436073 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell fibroblast endocrine cell pericyte epithelial cell stellate cell stem cell phagocyte muscle cell stromal cell smooth muscle cell thymic epithelial cell skeletal muscle cell mesenchymal cell Other: Cytokine Signaling in Immune system Degradation of the extracellular matrix Elastic fibre formation FYN Gene Information Basic Information Ensembl ID: ENSG00000010810 Description: FYN proto-oncogene%2C Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:4037] Location: 6:111660332-111873452 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Cellular responses to mechanical stimuli IKBKB Gene Information Basic Information Ensembl ID: ENSG00000104365 Description: inhibitor of nuclear factor kappa B kinase subunit beta [Source:HGNC Symbol;Acc:HGNC:5960] Location: 8:42271302-42332460 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell secretory cell T cell Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System ITGA5 Gene Information Basic Information Ensembl ID: ENSG00000161638 Description: integrin subunit alpha 5 [Source:HGNC Symbol;Acc:HGNC:6141] Location: 12:54395261-54419266 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell epithelial cell stromal cell smooth muscle cell trophoblast cell mesenchymal stem cell fibroblast Other: Elastic fibre formation Fibronectin matrix formation Cell surface interactions at the vascular wall ITGAV Gene Information Basic Information Ensembl ID: ENSG00000138448 Description: integrin subunit alpha V [Source:HGNC Symbol;Acc:HGNC:6150] Location: 2:186590010-186680901 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell glial cell stromal cell M cell endothelial cell Other: Adaptive Immune System Elastic fibre formation Innate Immune System ITGB1 Gene Information Basic Information Ensembl ID: ENSG00000150093 Description: integrin subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:6153] Location: 10:32887273-33005792 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stellate cell pericyte trophoblast cell epithelial cell stromal cell stem cell endothelial cell smooth muscle cell fibroblast mesenchymal stem cell Other: Laminin interactions Cell surface interactions at the vascular wall Cytokine Signaling in Immune system ITGB3 Gene Information Basic Information Ensembl ID: ENSG00000259207 Description: integrin subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:6156] Location: 17:47253827-47313743 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: platelet epithelial cell monocyte Other: ECM proteoglycans Elastic fibre formation Cell surface interactions at the vascular wall KDR Gene Information Basic Information Ensembl ID: ENSG00000128052 Description: kinase insert domain receptor [Source:HGNC Symbol;Acc:HGNC:6307] Location: 4:55078481-55125595 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell glial cell stromal cell mesothelial cell cancer stem cell Other: Integrin cell surface interactions Signaling by Receptor Tyrosine Kinases Cellular responses to mechanical stimuli MTOR Gene Information Basic Information Ensembl ID: ENSG00000198793 Description: mechanistic target of rapamycin kinase [Source:HGNC Symbol;Acc:HGNC:3942] Location: 1:11106535-11262556 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Adaptive Immune System Macroautophagy MTOR signalling NFKB1 Gene Information Basic Information Ensembl ID: ENSG00000109320 Description: nuclear factor kappa B subunit 1 [Source:HGNC Symbol;Acc:HGNC:7794] Location: 4:102501330-102617302 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System NLRP3 Gene Information Basic Information Ensembl ID: ENSG00000162711 Description: NLR family pyrin domain containing 3 [Source:HGNC Symbol;Acc:HGNC:16400] Location: 1:247332331-247449108 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell dendritic cell phagocyte monocyte Other: Parasitic Infection Pathways Viral Infection Pathways Innate Immune System PECAM1 Gene Information Basic Information Ensembl ID: ENSG00000261371 Description: platelet and endothelial cell adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:8823] Location: 17:64319415-64413776 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell neuron fibroblast monocyte pericyte smooth muscle cell endocrine cell epithelial cell platelet immune cell stromal cell hematopoietic stem cell lymphocyte mesenchymal stem cell endocardial cell Other: Innate Immune System Cell surface interactions at the vascular wall Integrin cell surface interactions PIK3CA Gene Information Basic Information Ensembl ID: ENSG00000121879 Description: phosphatidylinositol-4%2C5-bisphosphate 3-kinase catalytic subunit alpha [Source:HGNC Symbol;Acc:HGNC:8975] Location: 3:179148114-179240093 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System PIK3CD Gene Information Basic Information Ensembl ID: ENSG00000171608 Description: phosphatidylinositol-4%2C5-bisphosphate 3-kinase catalytic subunit delta [Source:HGNC Symbol;Acc:HGNC:8977] Location: 1:9629889-9729114 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: developing T cell T cell hematopoietic cell Other: Cytokine Signaling in Immune system Adaptive Immune System Metabolism of lipids RELA Gene Information Basic Information Ensembl ID: ENSG00000173039 Description: RELA proto-oncogene%2C NF-kB subunit [Source:HGNC Symbol;Acc:HGNC:9955] Location: 11:65653599-65663090 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System STAT1 Gene Information Basic Information Ensembl ID: ENSG00000115415 Description: signal transducer and activator of transcription 1 [Source:HGNC Symbol;Acc:HGNC:11362] Location: 2:190908460-191020960 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell Regulatory T cell CD8+ T cell leukocyte secretory cell monocyte epithelial cell Other: Cytokine Signaling in Immune system Signaling by NOTCH RNA Polymerase II Transcription
Cellular responses to stress Pathway Hierarchies & Genes Heme signaling (1 genes) Cellular responses to stimuli Cellular responses to stress Cellular response to hypoxia Regulation of gene expression by Hypoxia-inducible Factor Cellular response to heat stress HSF1-dependent transactivation Attenuation phase Cellular response to chemical stress KEAP1-NFE2L2 pathway Nuclear events mediated by NFE2L2 NFE2L2 regulating inflammation associated genes Heme signaling 1 genes NFE2L2 regulating inflammation associated genes (1 genes) Cellular responses to stimuli Cellular responses to stress Unfolded Protein Response (UPR) PERK regulates gene expression ATF4 activates genes in response to endoplasmic reticulum stress Cellular response to chemical stress KEAP1-NFE2L2 pathway Nuclear events mediated by NFE2L2 NFE2L2 regulating inflammation associated genes 1 genes Regulation of NFE2L2 gene expression (6 genes) Cellular responses to stimuli Cellular responses to stress Cellular Senescence Senescence-Associated Secretory Phenotype (SASP) 3 genes Cellular response to chemical stress KEAP1-NFE2L2 pathway 1 genes Nuclear events mediated by NFE2L2 Regulation of NFE2L2 gene expression 2 genes KEAP1-NFE2L2 pathway (3 genes) Cellular responses to stimuli Cellular responses to stress Cellular Senescence DNA Damage/Telomere Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) 2 genes Cellular response to chemical stress KEAP1-NFE2L2 pathway 1 genes Amino acids regulate mTORC1 (1 genes) Cellular responses to stimuli Cellular responses to stress Cellular response to heat stress HSF1-dependent transactivation Cellular response to starvation Amino acids regulate mTORC1 1 genes NFE2L2 regulates pentose phosphate pathway genes (1 genes) Cellular responses to stimuli Cellular responses to stress Cellular response to chemical stress KEAP1-NFE2L2 pathway Nuclear events mediated by NFE2L2 NFE2L2 regulates pentose phosphate pathway genes 1 genes NFE2L2 regulating TCA cycle genes (1 genes) Cellular responses to stimuli Cellular responses to stress Cellular response to chemical stress KEAP1-NFE2L2 pathway Nuclear events mediated by NFE2L2 NFE2L2 regulating TCA cycle genes 1 genes NFE2L2 regulating tumorigenic genes (5 genes) Cellular responses to stimuli Cellular responses to stress Cellular response to chemical stress KEAP1-NFE2L2 pathway Nuclear events mediated by NFE2L2 NFE2L2 regulating tumorigenic genes 5 genes Regulation of HSF1-mediated heat shock response (12 genes) Cellular responses to stimuli Cellular responses to stress Cellular Senescence Oxidative Stress Induced Senescence 10 genes Cellular response to heat stress Regulation of HSF1-mediated heat shock response 2 genes Regulation of HSF1-mediated heat shock response (2 genes) Cellular responses to stimuli Cellular responses to stress Cellular Senescence DNA Damage/Telomere Stress Induced Senescence 1 genes Cellular response to heat stress Regulation of HSF1-mediated heat shock response 1 genes Regulation of NFE2L2 gene expression (1 genes) Cellular responses to stimuli Cellular responses to stress Cellular response to chemical stress KEAP1-NFE2L2 pathway Nuclear events mediated by NFE2L2 Regulation of NFE2L2 gene expression 1 genes Heme signaling (2 genes) Cellular responses to stimuli Cellular responses to stress Cellular response to chemical stress Cytoprotection by HMOX1 1 genes Heme signaling 1 genes Mitochondrial unfolded protein response (UPRmt) (4 genes) Cellular responses to stimuli Cellular responses to stress Cellular response to chemical stress KEAP1-NFE2L2 pathway 3 genes Mitochondrial unfolded protein response (UPRmt) 1 genes Oncogene Induced Senescence (1 genes) Cellular responses to stimuli Cellular responses to stress Cellular Senescence Oncogene Induced Senescence 1 genes Regulation of HSF1-mediated heat shock response (1 genes) Cellular responses to stimuli Cellular responses to stress Cellular response to heat stress Regulation of HSF1-mediated heat shock response 1 genes Regulation of gene expression by Hypoxia-inducible Factor (2 genes) Cellular responses to stimuli Cellular responses to stress Cellular response to hypoxia Regulation of gene expression by Hypoxia-inducible Factor 2 genes HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (2 genes) Cellular responses to stimuli Cellular responses to stress HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 2 genes Heme signaling (2 genes) Cellular responses to stimuli Cellular responses to stress Heme signaling 2 genes Mitochondrial unfolded protein response (UPRmt) (1 genes) Cellular responses to stimuli Cellular responses to stress Mitochondrial unfolded protein response (UPRmt) 1 genes	AKT1 Gene Information Basic Information Ensembl ID: ENSG00000142208 Description: AKT serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:391] Location: 14:104769349-104795759 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Integrin signaling Apoptosis Cytokine Signaling in Immune system AKT2 Gene Information Basic Information Ensembl ID: ENSG00000105221 Description: AKT serine/threonine kinase 2 [Source:HGNC Symbol;Acc:HGNC:392] Location: 19:40230317-40285536 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: T cell Other: Apoptosis Cytokine Signaling in Immune system Adaptive Immune System AKT3 Gene Information Basic Information Ensembl ID: ENSG00000117020 Description: AKT serine/threonine kinase 3 [Source:HGNC Symbol;Acc:HGNC:393] Location: 1:243488233-243851079 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell neuron epithelial cell T cell fibroblast glial cell CD8+ T cell schwann cell Specialized T cell excitatory neuron smooth muscle cell Other: Apoptosis Cytokine Signaling in Immune system Adaptive Immune System AR Gene Information Basic Information Ensembl ID: ENSG00000169083 Description: androgen receptor [Source:HGNC Symbol;Acc:HGNC:644] Location: X:67544021-67730619 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: fibroblast stromal cell epithelial cell adipocyte Other: Cellular responses to stress Post-translational protein modification RNA Polymerase II Transcription ATM Gene Information Basic Information Ensembl ID: ENSG00000149311 Description: ATM serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:795] Location: 11:108222804-108369102 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell T cell phagocyte hematopoietic cell Specialized T cell developing T cell Naive B cell lymphocyte Other: Meiosis Macroautophagy Cellular responses to stress ATR Gene Information Basic Information Ensembl ID: ENSG00000175054 Description: ATR serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:882] Location: 3:142449007-142578733 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Meiosis Cellular responses to stress DNA Double-Strand Break Repair BCL2 Gene Information Basic Information Ensembl ID: ENSG00000171791 Description: BCL2 apoptosis regulator [Source:HGNC Symbol;Acc:HGNC:990] Location: 18:63123346-63320128 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: cancer cell Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System BCL2L1 Gene Information Basic Information Ensembl ID: ENSG00000171552 Description: BCL2 like 1 [Source:HGNC Symbol;Acc:HGNC:992] Location: 20:31664452-31723989 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System BMI1 Gene Information Basic Information Ensembl ID: ENSG00000168283 Description: BMI1 proto-oncogene%2C polycomb ring finger [Source:HGNC Symbol;Acc:HGNC:1066] Location: 10:22321099-22331484 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cellular responses to stress Post-translational protein modification RNA Polymerase II Transcription BRCA1 Gene Information Basic Information Ensembl ID: ENSG00000012048 Description: BRCA1 DNA repair associated [Source:HGNC Symbol;Acc:HGNC:1100] Location: 17:43044295-43170245 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: cancer cell Other: Meiosis Cellular responses to stress DNA Double-Strand Break Repair CCL2 Gene Information Basic Information Ensembl ID: ENSG00000108691 Description: C-C motif chemokine ligand 2 [Source:HGNC Symbol;Acc:HGNC:10618] Location: 17:34255274-34257208 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stromal cell endothelial cell neuron pericyte epithelial cell stem cell phagocyte fibroblast glial cell smooth muscle cell monocyte antigen presenting cell macrophage mesothelial cell transient amplifying cell Other: Cytokine Signaling in Immune system Cellular responses to stress Signaling by GPCR CCNE1 Gene Information Basic Information Ensembl ID: ENSG00000105173 Description: cyclin E1 [Source:HGNC Symbol;Acc:HGNC:1589] Location: 19:29811991-29824312 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: trophoblast cell Other: Cellular responses to stress Protein folding Synthesis of DNA CDK2 Gene Information Basic Information Ensembl ID: ENSG00000123374 Description: cyclin dependent kinase 2 [Source:HGNC Symbol;Acc:HGNC:1771] Location: 12:55966781-55972789 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Meiosis Cellular responses to stress DNA Double-Strand Break Repair CDK4 Gene Information Basic Information Ensembl ID: ENSG00000135446 Description: cyclin dependent kinase 4 [Source:HGNC Symbol;Acc:HGNC:1773] Location: 12:57747727-57756013 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: T cell schwann cell progenitor cell neural crest cell Other: Adipogenesis Meiosis Cellular responses to stress CDK6 Gene Information Basic Information Ensembl ID: ENSG00000105810 Description: cyclin dependent kinase 6 [Source:HGNC Symbol;Acc:HGNC:1777] Location: 7:92604921-92836573 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell skeletal muscle cell hematopoietic stem cell fibroblast lymphoid progenitor cell progenitor cell mesangial cell megakaryocyte hematopoietic progenitor cell Other: Cellular responses to stress Cell Cycle, Mitotic RNA Polymerase II Transcription CDKN1A Gene Information Basic Information Ensembl ID: ENSG00000124762 Description: cyclin dependent kinase inhibitor 1A [Source:HGNC Symbol;Acc:HGNC:1784] Location: 6:36676460-36687397 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell pericyte dendritic cell smooth muscle cell fibroblast muscle cell monocyte Other: Cytokine Signaling in Immune system Cellular responses to stress Post-translational protein modification CREBBP Gene Information Basic Information Ensembl ID: ENSG00000005339 Description: CREB binding protein [Source:HGNC Symbol;Acc:HGNC:2348] Location: 16:3725054-3880713 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes BMAL1:CLOCK,NPAS2 activates circadian expression E2F1 Gene Information Basic Information Ensembl ID: ENSG00000101412 Description: E2F transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:3113] Location: 20:33675477-33686385 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Signaling by NOTCH Cellular responses to stress EGF Gene Information Basic Information Ensembl ID: ENSG00000138798 Description: epidermal growth factor [Source:HGNC Symbol;Acc:HGNC:3229] Location: 4:109912883-110013766 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: skeletal muscle cell epithelial cell glial cell Other: Signaling by NOTCH Membrane Trafficking Cellular responses to stress ESR1 Gene Information Basic Information Ensembl ID: ENSG00000091831 Description: estrogen receptor 1 [Source:HGNC Symbol;Acc:HGNC:3467] Location: 6:151656691-152129619 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: fibroblast stromal cell plasma cell Other: Cellular responses to stress Post-translational protein modification RNA Polymerase II Transcription ETS1 Gene Information Basic Information Ensembl ID: ENSG00000134954 Description: ETS proto-oncogene 1%2C transcription factor [Source:HGNC Symbol;Acc:HGNC:3488] Location: 11:128458761-128587558 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell natural killer cell developing T cell Regulatory T cell CD4+ T cell lymphoid progenitor cell CD8+ T cell T cell lymphocyte Other: Cellular responses to stress EZH2 Gene Information Basic Information Ensembl ID: ENSG00000106462 Description: enhancer of zeste 2 polycomb repressive complex 2 subunit [Source:HGNC Symbol;Acc:HGNC:3527] Location: 7:148807257-148884321 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell Other: Epigenetic regulation of gene expression Cellular responses to stress Chromatin modifying enzymes G6PD Gene Information Basic Information Ensembl ID: ENSG00000160211 Description: glucose-6-phosphate dehydrogenase [Source:HGNC Symbol;Acc:HGNC:4057] Location: X:154517825-154547572 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Specialized T cell natural killer cell Other: Cellular responses to stress Metabolism of carbohydrates and carbohydrate derivatives RNA Polymerase II Transcription HDAC3 Gene Information Basic Information Ensembl ID: ENSG00000171720 Description: histone deacetylase 3 [Source:HGNC Symbol;Acc:HGNC:4854] Location: 5:141620876-141636849 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Death Receptor Signaling Signaling by NOTCH Mitochondrial biogenesis HIF1A Gene Information Basic Information Ensembl ID: ENSG00000100644 Description: hypoxia inducible factor 1 subunit alpha [Source:HGNC Symbol;Acc:HGNC:4910] Location: 14:61695513-61748259 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell macrophage phagocyte microglia granulocyte monocyte myeloid cell antigen presenting cell innate lymphoid cell dendritic cell Other: Cytokine Signaling in Immune system Signaling by NOTCH Cellular responses to stress IDH1 Gene Information Basic Information Ensembl ID: ENSG00000138413 Description: isocitrate dehydrogenase (NADP(+)) 1 [Source:HGNC Symbol;Acc:HGNC:5382] Location: 2:208236229-208266074 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Innate Immune System Metabolism of vitamins and cofactors Cellular responses to stress IFNB1 Gene Information Basic Information Ensembl ID: ENSG00000171855 Description: interferon beta 1 [Source:HGNC Symbol;Acc:HGNC:5434] Location: 9:21077104-21077942 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Innate Immune System Cellular responses to stress IL1A Gene Information Basic Information Ensembl ID: ENSG00000115008 Description: interleukin 1 alpha [Source:HGNC Symbol;Acc:HGNC:5991] Location: 2:112773925-112784493 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell Other: Cytokine Signaling in Immune system Cellular responses to stress Regulated Necrosis IL6 Gene Information Basic Information Ensembl ID: ENSG00000136244 Description: interleukin 6 [Source:HGNC Symbol;Acc:HGNC:6018] Location: 7:22725884-22732002 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte endothelial cell stromal cell smooth muscle cell CD4+ T cell vascular cell immune cell Other: Cytokine Signaling in Immune system Cellular responses to stress Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MAP2K4 Gene Information Basic Information Ensembl ID: ENSG00000065559 Description: mitogen-activated protein kinase kinase 4 [Source:HGNC Symbol;Acc:HGNC:6844] Location: 17:12020829-12143830 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stem cell Other: Cytokine Signaling in Immune system Innate Immune System Cellular responses to stress MAP3K5 Gene Information Basic Information Ensembl ID: ENSG00000197442 Description: mitogen-activated protein kinase kinase kinase 5 [Source:HGNC Symbol;Acc:HGNC:6857] Location: 6:136557046-136793097 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell Regulatory T cell fibroblast monocyte trophoblast cell adrenal cortical cell astrocyte smooth muscle cell innate lymphoid cell Other: Cellular responses to stress MAPK1 Gene Information Basic Information Ensembl ID: ENSG00000100030 Description: mitogen-activated protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:6871] Location: 22:21759657-21867680 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Transmission across Chemical Synapses Signaling by NODAL MAPK14 Gene Information Basic Information Ensembl ID: ENSG00000112062 Description: mitogen-activated protein kinase 14 [Source:HGNC Symbol;Acc:HGNC:6876] Location: 6:36027752-36122511 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Platelet homeostasis Cytokine Signaling in Immune system Mitochondrial biogenesis MAPK3 Gene Information Basic Information Ensembl ID: ENSG00000102882 Description: mitogen-activated protein kinase 3 [Source:HGNC Symbol;Acc:HGNC:6877] Location: 16:30114105-30123506 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Transmission across Chemical Synapses Signaling by NODAL MAPK8 Gene Information Basic Information Ensembl ID: ENSG00000107643 Description: mitogen-activated protein kinase 8 [Source:HGNC Symbol;Acc:HGNC:6881] Location: 10:48306639-48439360 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System MTOR Gene Information Basic Information Ensembl ID: ENSG00000198793 Description: mechanistic target of rapamycin kinase [Source:HGNC Symbol;Acc:HGNC:3942] Location: 1:11106535-11262556 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Adaptive Immune System Macroautophagy MTOR signalling MYC Gene Information Basic Information Ensembl ID: ENSG00000136997 Description: MYC proto-oncogene%2C bHLH transcription factor [Source:HGNC Symbol;Acc:HGNC:7553] Location: 8:127735434-127742951 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte epithelial cell fibroblast stromal cell smooth muscle cell hematopoietic progenitor cell endothelial cell stem cell erythroblast muscle cell progenitor cell transient amplifying cell cancer stem cell B cell erythroid lineage cell Other: Cytokine Signaling in Immune system Signaling by NOTCH Signaling by WNT NFKB1 Gene Information Basic Information Ensembl ID: ENSG00000109320 Description: nuclear factor kappa B subunit 1 [Source:HGNC Symbol;Acc:HGNC:7794] Location: 4:102501330-102617302 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System NLRP3 Gene Information Basic Information Ensembl ID: ENSG00000162711 Description: NLR family pyrin domain containing 3 [Source:HGNC Symbol;Acc:HGNC:16400] Location: 1:247332331-247449108 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell dendritic cell phagocyte monocyte Other: Parasitic Infection Pathways Viral Infection Pathways Innate Immune System NOTCH1 Gene Information Basic Information Ensembl ID: ENSG00000148400 Description: notch receptor 1 [Source:HGNC Symbol;Acc:HGNC:7881] Location: 9:136494433-136546048 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte T cell stem cell cancer cell Other: Signaling by NOTCH Regulation of beta-cell development Cellular responses to stress PDGFA Gene Information Basic Information Ensembl ID: ENSG00000197461 Description: platelet derived growth factor subunit A [Source:HGNC Symbol;Acc:HGNC:8799] Location: 7:497258-520296 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte smooth muscle cell Specialized T cell secretory cell Other: Cellular responses to stress Non-integrin membrane-ECM interactions MAPK family signaling cascades PGR Gene Information Basic Information Ensembl ID: ENSG00000082175 Description: progesterone receptor [Source:HGNC Symbol;Acc:HGNC:8910] Location: 11:101029624-101129813 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cellular responses to stress Post-translational protein modification RNA Polymerase II Transcription PPARGC1A Gene Information Basic Information Ensembl ID: ENSG00000109819 Description: PPARG coactivator 1 alpha [Source:HGNC Symbol;Acc:HGNC:9237] Location: 4:23755041-23904089 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Mitochondrial biogenesis Epigenetic regulation of gene expression Cellular responses to stress RB1 Gene Information Basic Information Ensembl ID: ENSG00000139687 Description: RB transcriptional corepressor 1 [Source:HGNC Symbol;Acc:HGNC:9884] Location: 13:48303744-48599436 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell endothelial cell microglia neuron Other: Epigenetic regulation of gene expression Cellular responses to stress Cell junction organization RELA Gene Information Basic Information Ensembl ID: ENSG00000173039 Description: RELA proto-oncogene%2C NF-kB subunit [Source:HGNC Symbol;Acc:HGNC:9955] Location: 11:65653599-65663090 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System STAT3 Gene Information Basic Information Ensembl ID: ENSG00000168610 Description: signal transducer and activator of transcription 3 [Source:HGNC Symbol;Acc:HGNC:11364] Location: 17:42313324-42388568 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: cancer cell Other: Apoptosis Cytokine Signaling in Immune system Cellular responses to stress TLR4 Gene Information Basic Information Ensembl ID: ENSG00000136869 Description: toll like receptor 4 [Source:HGNC Symbol;Acc:HGNC:11850] Location: 9:117704175-117724735 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell myeloid cell Other: Apoptosis Adaptive Immune System Innate Immune System TP53 Gene Information Basic Information Ensembl ID: ENSG00000141510 Description: tumor protein p53 [Source:HGNC Symbol;Acc:HGNC:11998] Location: 17:7661779-7687546 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Cytokine Signaling in Immune system Signaling by NOTCH VEGFA Gene Information Basic Information Ensembl ID: ENSG00000112715 Description: vascular endothelial growth factor A [Source:HGNC Symbol;Acc:HGNC:12680] Location: 6:43770184-43786487 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell macrophage epithelial cell stem cell monocyte fibroblast microglia pancreatic cell granulocyte secretory cell astrocyte dendritic cell endothelial cell Other: Cytokine Signaling in Immune system Cellular responses to stress RNA Polymerase II Transcription
Chaperone Mediated Autophagy Pathway Hierarchies & Genes Chaperone Mediated Autophagy (1 genes) Autophagy Chaperone Mediated Autophagy 1 genes	VIM Gene Information Basic Information Ensembl ID: ENSG00000026025 Description: vimentin [Source:HGNC Symbol;Acc:HGNC:12692] Location: 10:17228241-17237593 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell pericyte macrophage monocyte stem cell embryonic cell phagocyte fibroblast glial cell smooth muscle cell oligodendrocyte precursor cell bone cell mast cell granulocyte antigen presenting cell interstitial cell mesenchymal cell mesenchymal stem cell Other: Apoptosis Cytokine Signaling in Immune system Macroautophagy
Chromatin modifying enzymes Pathway Hierarchies & Genes HATs acetylate histones (1 genes) Chromatin organization Chromatin modifying enzymes HATs acetylate histones 1 genes PKMTs methylate histone lysines (3 genes) Chromatin organization Chromatin modifying enzymes PKMTs methylate histone lysines 3 genes RMTs methylate histone arginines (2 genes) Chromatin organization Chromatin modifying enzymes RMTs methylate histone arginines 2 genes RMTs methylate histone arginines (5 genes) Chromatin organization Chromatin modifying enzymes RMTs methylate histone arginines 5 genes	CCND1 Gene Information Basic Information Ensembl ID: ENSG00000110092 Description: cyclin D1 [Source:HGNC Symbol;Acc:HGNC:1582] Location: 11:69641156-69654474 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell endothelial cell pericyte monocyte fibroblast glial cell dendritic cell pancreatic cell M cell oligodendrocyte Other: Cytokine Signaling in Immune system Signaling by NOTCH Chromatin modifying enzymes CDK4 Gene Information Basic Information Ensembl ID: ENSG00000135446 Description: cyclin dependent kinase 4 [Source:HGNC Symbol;Acc:HGNC:1773] Location: 12:57747727-57756013 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: T cell schwann cell progenitor cell neural crest cell Other: Adipogenesis Meiosis Cellular responses to stress CREBBP Gene Information Basic Information Ensembl ID: ENSG00000005339 Description: CREB binding protein [Source:HGNC Symbol;Acc:HGNC:2348] Location: 16:3725054-3880713 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes BMAL1:CLOCK,NPAS2 activates circadian expression DNMT3A Gene Information Basic Information Ensembl ID: ENSG00000119772 Description: DNA methyltransferase 3 alpha [Source:HGNC Symbol;Acc:HGNC:2978] Location: 2:25227855-25342590 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Defective pyroptosis Epigenetic regulation of gene expression Chromatin modifying enzymes EZH2 Gene Information Basic Information Ensembl ID: ENSG00000106462 Description: enhancer of zeste 2 polycomb repressive complex 2 subunit [Source:HGNC Symbol;Acc:HGNC:3527] Location: 7:148807257-148884321 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell Other: Epigenetic regulation of gene expression Cellular responses to stress Chromatin modifying enzymes HDAC3 Gene Information Basic Information Ensembl ID: ENSG00000171720 Description: histone deacetylase 3 [Source:HGNC Symbol;Acc:HGNC:4854] Location: 5:141620876-141636849 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Death Receptor Signaling Signaling by NOTCH Mitochondrial biogenesis JAK2 Gene Information Basic Information Ensembl ID: ENSG00000096968 Description: Janus kinase 2 [Source:HGNC Symbol;Acc:HGNC:6192] Location: 9:4984390-5129948 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: fibroblast basophil dendritic cell Other: Chromatin modifying enzymes Cytokine Signaling in Immune system Signaling by Leptin NFKB1 Gene Information Basic Information Ensembl ID: ENSG00000109320 Description: nuclear factor kappa B subunit 1 [Source:HGNC Symbol;Acc:HGNC:7794] Location: 4:102501330-102617302 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System NFKB2 Gene Information Basic Information Ensembl ID: ENSG00000077150 Description: nuclear factor kappa B subunit 2 [Source:HGNC Symbol;Acc:HGNC:7795] Location: 10:102394110-102402524 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: CD4+ T cell Other: Cytokine Signaling in Immune system Innate Immune System Chromatin modifying enzymes RELA Gene Information Basic Information Ensembl ID: ENSG00000173039 Description: RELA proto-oncogene%2C NF-kB subunit [Source:HGNC Symbol;Acc:HGNC:9955] Location: 11:65653599-65663090 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System SMARCA4 Gene Information Basic Information Ensembl ID: ENSG00000127616 Description: SWI/SNF related%2C matrix associated%2C actin dependent regulator of chromatin%2C subfamily a%2C member 4 [Source:HGNC Symbol;Acc:HGNC:11100] Location: 19:10960932-11079426 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell epithelial cell fibroblast Other: Cytokine Signaling in Immune system Signaling by WNT Epigenetic regulation of gene expression
Chromosome Maintenance Pathway Hierarchies & Genes Telomere Extension By Telomerase (1 genes) Cell Cycle Chromosome Maintenance Telomere Maintenance Extension of Telomeres Telomere Extension By Telomerase 1 genes	CDK2 Gene Information Basic Information Ensembl ID: ENSG00000123374 Description: cyclin dependent kinase 2 [Source:HGNC Symbol;Acc:HGNC:1771] Location: 12:55966781-55972789 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Meiosis Cellular responses to stress DNA Double-Strand Break Repair
Collagen formation Pathway Hierarchies & Genes Assembly of collagen fibrils and other multimeric structures (2 genes) Extracellular matrix organization Collagen formation Collagen biosynthesis and modifying enzymes Collagen chain trimerization Assembly of collagen fibrils and other multimeric structures 2 genes Anchoring fibril formation (2 genes) Extracellular matrix organization Collagen formation Assembly of collagen fibrils and other multimeric structures Anchoring fibril formation 2 genes Assembly of collagen fibrils and other multimeric structures (3 genes) Extracellular matrix organization Collagen formation Assembly of collagen fibrils and other multimeric structures 3 genes	COL11A1 Gene Information Basic Information Ensembl ID: ENSG00000060718 Description: collagen type XI alpha 1 chain [Source:HGNC Symbol;Acc:HGNC:2186] Location: 1:102876467-103108872 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte fibroblast stromal cell oligodendrocyte precursor cell melanocyte oligodendrocyte Other: Degradation of the extracellular matrix Collagen formation Non-integrin membrane-ECM interactions COL5A1 Gene Information Basic Information Ensembl ID: ENSG00000130635 Description: collagen type V alpha 1 chain [Source:HGNC Symbol;Acc:HGNC:2209] Location: 9:134641803-134844843 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron pericyte stromal cell stellate cell fibroblast stem cell embryonic cell mesenchymal cell skeletal muscle cell Other: Degradation of the extracellular matrix Collagen formation Fibronectin matrix formation ITGA6 Gene Information Basic Information Ensembl ID: ENSG00000091409 Description: integrin subunit alpha 6 [Source:HGNC Symbol;Acc:HGNC:6142] Location: 2:172234216-172506459 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell goblet cell kidney cell pericyte epithelial cell embryonic cell stem cell glial cell stromal cell Other: Collagen formation Cell surface interactions at the vascular wall Integrin cell surface interactions ITGB4 Gene Information Basic Information Ensembl ID: ENSG00000132470 Description: integrin subunit beta 4 [Source:HGNC Symbol;Acc:HGNC:6158] Location: 17:75721328-75757818 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron epithelial cell schwann cell astrocyte dendritic cell M cell endothelial cell Other: Collagen formation Laminin interactions Non-integrin membrane-ECM interactions LAMB3 Gene Information Basic Information Ensembl ID: ENSG00000196878 Description: laminin subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:6490] Location: 1:209614870-209652425 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell stem cell pancreatic cell goblet cell M cell Other: Degradation of the extracellular matrix Collagen formation Laminin interactions LAMC2 Gene Information Basic Information Ensembl ID: ENSG00000058085 Description: laminin subunit gamma 2 [Source:HGNC Symbol;Acc:HGNC:6493] Location: 1:183186238-183245127 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell pancreatic cell goblet cell M cell stem cell Other: Degradation of the extracellular matrix Collagen formation Laminin interactions MMP9 Gene Information Basic Information Ensembl ID: ENSG00000100985 Description: matrix metallopeptidase 9 [Source:HGNC Symbol;Acc:HGNC:7176] Location: 20:46008908-46016561 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell macrophage phagocyte neutrophil monocyte osteoclast Other: Cytokine Signaling in Immune system Degradation of the extracellular matrix Collagen formation
Cytokine Signaling in Immune system Pathway Hierarchies & Genes Signaling by CSF1 (M-CSF) in myeloid cells (9 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-6 family signaling Interleukin-6 signaling 3 genes Prolactin receptor signaling Interferon Signaling Interferon gamma signaling Regulation of IFNG signaling FLT3 Signaling 1 genes STAT5 Activation 1 genes Signaling by CSF3 (G-CSF) 3 genes Signaling by CSF1 (M-CSF) in myeloid cells 1 genes Growth hormone receptor signaling (3 genes) Immune System Cytokine Signaling in Immune system Prolactin receptor signaling Signaling by Interleukins 1 genes Interleukin-2 family signaling Interleukin-15 signaling FLT3 Signaling STAT5 Activation Signaling by CSF3 (G-CSF) Inactivation of CSF3 (G-CSF) signaling Growth hormone receptor signaling 2 genes NIK-->noncanonical NF-kB signaling (3 genes) Immune System Cytokine Signaling in Immune system Interferon Signaling Antiviral mechanism by IFN-stimulated genes PKR-mediated signaling Signaling by Interleukins Interleukin-1 family signaling Interleukin-1 signaling 2 genes TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling 1 genes Growth hormone receptor signaling (2 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-3, Interleukin-5 and GM-CSF signaling Regulation of signaling by CBL Signaling by CSF3 (G-CSF) Inactivation of CSF3 (G-CSF) signaling Signaling by CSF1 (M-CSF) in myeloid cells 1 genes Growth hormone receptor signaling 1 genes Inactivation of CSF3 (G-CSF) signaling (4 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-2 family signaling Interleukin-2 signaling 2 genes FLT3 Signaling FLT3 signaling through SRC family kinases 1 genes Signaling by CSF3 (G-CSF) Inactivation of CSF3 (G-CSF) signaling 1 genes Regulation of IFNG signaling (3 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-12 family signaling Interleukin-12 signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 2 genes Interferon Signaling Interferon gamma signaling Regulation of IFNG signaling 1 genes Growth hormone receptor signaling (7 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-17 signaling 6 genes Interferon Signaling Interferon gamma signaling IFNG signaling activates MAPKs Growth hormone receptor signaling 1 genes Growth hormone receptor signaling (5 genes) Immune System Cytokine Signaling in Immune system Interferon Signaling Antiviral mechanism by IFN-stimulated genes ISG15 antiviral mechanism 4 genes Signaling by Interleukins Interleukin-17 signaling Growth hormone receptor signaling 1 genes NIK-->noncanonical NF-kB signaling (6 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-1 family signaling Interleukin-1 processing 5 genes TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling 1 genes Signaling by CSF1 (M-CSF) in myeloid cells (7 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-2 family signaling Interleukin receptor SHC signaling 5 genes FLT3 Signaling 1 genes Signaling by CSF1 (M-CSF) in myeloid cells 1 genes TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (12 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-1 family signaling Interleukin-1 signaling 11 genes TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 1 genes Inactivation of CSF3 (G-CSF) signaling (7 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Other interleukin signaling 3 genes Signaling by CSF3 (G-CSF) 3 genes Inactivation of CSF3 (G-CSF) signaling 1 genes TNFs bind their physiological receptors (32 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-4 and Interleukin-13 signaling 28 genes TNFR2 non-canonical NF-kB pathway 1 genes TNFs bind their physiological receptors 3 genes TNFs bind their physiological receptors (17 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-10 signaling 13 genes TNFR2 non-canonical NF-kB pathway 1 genes TNFs bind their physiological receptors 3 genes Growth hormone receptor signaling (6 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-7 signaling 5 genes Growth hormone receptor signaling 1 genes IL-6-type cytokine receptor ligand interactions (4 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-6 family signaling IL-6-type cytokine receptor ligand interactions 4 genes Interleukin-12 signaling (2 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-12 family signaling Interleukin-12 signaling 2 genes Interleukin-15 signaling (5 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-2 family signaling Interleukin-15 signaling 5 genes Interleukin-18 signaling (2 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-1 family signaling Interleukin-18 signaling 2 genes Interleukin-21 signaling (2 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-2 family signaling Interleukin-21 signaling 2 genes Interleukin-23 signaling (2 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-12 family signaling Interleukin-23 signaling 2 genes Interleukin-33 signaling (1 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-1 family signaling Interleukin-33 signaling 1 genes Interleukin-35 Signalling (3 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-12 family signaling Interleukin-35 Signalling 3 genes Interleukin-36 pathway (1 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-1 family signaling Interleukin-36 pathway 1 genes Interleukin-37 signaling (3 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-1 family signaling Interleukin-37 signaling 3 genes Interleukin-38 signaling (1 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-1 family signaling Interleukin-38 signaling 1 genes Interleukin-9 signaling (1 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-2 family signaling Interleukin-9 signaling 1 genes OAS antiviral response (1 genes) Immune System Cytokine Signaling in Immune system Interferon Signaling Antiviral mechanism by IFN-stimulated genes OAS antiviral response 1 genes Regulation of IFNA/IFNB signaling (3 genes) Immune System Cytokine Signaling in Immune system Interferon Signaling Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling 3 genes Regulation of IFNG signaling (2 genes) Immune System Cytokine Signaling in Immune system Interferon Signaling Interferon gamma signaling Regulation of IFNG signaling 2 genes Signaling by CSF1 (M-CSF) in myeloid cells (5 genes) Immune System Cytokine Signaling in Immune system FLT3 Signaling 4 genes Signaling by CSF3 (G-CSF) Signaling by CSF1 (M-CSF) in myeloid cells 1 genes Interferon gamma signaling (6 genes) Immune System Cytokine Signaling in Immune system Interferon Signaling Interferon gamma signaling 6 genes Interleukin-2 family signaling (1 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-2 family signaling 1 genes Interleukin-20 family signaling (4 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-20 family signaling 4 genes Modulation of host responses by IFN-stimulated genes (1 genes) Immune System Cytokine Signaling in Immune system Interferon Signaling Modulation of host responses by IFN-stimulated genes 1 genes STAT5 Activation (1 genes) Immune System Cytokine Signaling in Immune system FLT3 Signaling STAT5 Activation 1 genes TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (5 genes) Immune System Cytokine Signaling in Immune system TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 5 genes TNFs bind their physiological receptors (17 genes) Immune System Cytokine Signaling in Immune system TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors 17 genes	AKT1 Gene Information Basic Information Ensembl ID: ENSG00000142208 Description: AKT serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:391] Location: 14:104769349-104795759 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Integrin signaling Apoptosis Cytokine Signaling in Immune system AKT2 Gene Information Basic Information Ensembl ID: ENSG00000105221 Description: AKT serine/threonine kinase 2 [Source:HGNC Symbol;Acc:HGNC:392] Location: 19:40230317-40285536 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: T cell Other: Apoptosis Cytokine Signaling in Immune system Adaptive Immune System AKT3 Gene Information Basic Information Ensembl ID: ENSG00000117020 Description: AKT serine/threonine kinase 3 [Source:HGNC Symbol;Acc:HGNC:393] Location: 1:243488233-243851079 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell neuron epithelial cell T cell fibroblast glial cell CD8+ T cell schwann cell Specialized T cell excitatory neuron smooth muscle cell Other: Apoptosis Cytokine Signaling in Immune system Adaptive Immune System BCL2 Gene Information Basic Information Ensembl ID: ENSG00000171791 Description: BCL2 apoptosis regulator [Source:HGNC Symbol;Acc:HGNC:990] Location: 18:63123346-63320128 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: cancer cell Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System BCL2L1 Gene Information Basic Information Ensembl ID: ENSG00000171552 Description: BCL2 like 1 [Source:HGNC Symbol;Acc:HGNC:992] Location: 20:31664452-31723989 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System BIRC5 Gene Information Basic Information Ensembl ID: ENSG00000089685 Description: baculoviral IAP repeat containing 5 [Source:HGNC Symbol;Acc:HGNC:593] Location: 17:78214186-78225636 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell glial cell epithelial cell erythroid lineage cell progenitor cell cancer stem cell proliferative cell Other: Cytokine Signaling in Immune system Post-translational protein modification Cell Cycle, Mitotic CASP3 Gene Information Basic Information Ensembl ID: ENSG00000164305 Description: caspase 3 [Source:HGNC Symbol;Acc:HGNC:1504] Location: 4:184627696-184650062 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron mast cell innate lymphoid cell progenitor cell stem cell basal cell Other: Apoptosis Cytokine Signaling in Immune system Degradation of the extracellular matrix CASP8 Gene Information Basic Information Ensembl ID: ENSG00000064012 Description: caspase 8 [Source:HGNC Symbol;Acc:HGNC:1509] Location: 2:201233443-201361836 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System CCL19 Gene Information Basic Information Ensembl ID: ENSG00000172724 Description: C-C motif chemokine ligand 19 [Source:HGNC Symbol;Acc:HGNC:10617] Location: 9:34689570-34691276 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stromal cell pericyte epithelial cell endothelial cell Other: Cytokine Signaling in Immune system Signaling by GPCR CCL2 Gene Information Basic Information Ensembl ID: ENSG00000108691 Description: C-C motif chemokine ligand 2 [Source:HGNC Symbol;Acc:HGNC:10618] Location: 17:34255274-34257208 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stromal cell endothelial cell neuron pericyte epithelial cell stem cell phagocyte fibroblast glial cell smooth muscle cell monocyte antigen presenting cell macrophage mesothelial cell transient amplifying cell Other: Cytokine Signaling in Immune system Cellular responses to stress Signaling by GPCR CCL20 Gene Information Basic Information Ensembl ID: ENSG00000115009 Description: C-C motif chemokine ligand 20 [Source:HGNC Symbol;Acc:HGNC:10619] Location: 2:227805739-227817564 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: phagocyte CD4+ T cell monocyte fibroblast epithelial cell macrophage M cell dendritic cell Other: Cytokine Signaling in Immune system Signaling by GPCR CCL22 Gene Information Basic Information Ensembl ID: ENSG00000102962 Description: C-C motif chemokine ligand 22 [Source:HGNC Symbol;Acc:HGNC:10621] Location: 16:57358783-57366189 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell Specialized T cell Other: Cytokine Signaling in Immune system Innate Immune System Signaling by GPCR CCND1 Gene Information Basic Information Ensembl ID: ENSG00000110092 Description: cyclin D1 [Source:HGNC Symbol;Acc:HGNC:1582] Location: 11:69641156-69654474 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell endothelial cell pericyte monocyte fibroblast glial cell dendritic cell pancreatic cell M cell oligodendrocyte Other: Cytokine Signaling in Immune system Signaling by NOTCH Chromatin modifying enzymes CCR1 Gene Information Basic Information Ensembl ID: ENSG00000163823 Description: C-C motif chemokine receptor 1 [Source:HGNC Symbol;Acc:HGNC:1602] Location: 3:46201711-46208313 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: macrophage myeloid cell monocyte Other: Cytokine Signaling in Immune system Signaling by GPCR CCR2 Gene Information Basic Information Ensembl ID: ENSG00000121807 Description: C-C motif chemokine receptor 2 [Source:HGNC Symbol;Acc:HGNC:1603] Location: 3:46353864-46360940 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: plasma cell monocyte Other: Cytokine Signaling in Immune system Innate Immune System Signaling by GPCR CCR5 Gene Information Basic Information Ensembl ID: ENSG00000160791 Description: C-C motif chemokine receptor 5 [Source:HGNC Symbol;Acc:HGNC:1606] Location: 3:46370946-46376206 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: CD8+ T cell developing T cell Other: Cytokine Signaling in Immune system Signaling by GPCR Viral Infection Pathways CD27 Gene Information Basic Information Ensembl ID: ENSG00000139193 Description: CD27 molecule [Source:HGNC Symbol;Acc:HGNC:11922] Location: 12:6444955-6451718 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: CD8+ T cell developing T cell T cell Regulatory T cell Naive B cell Follicular B cell plasma cell lymphocyte memory B cell memory T cell plasmablast B cell innate lymphoid cell Other: Cytokine Signaling in Immune system CD4 Gene Information Basic Information Ensembl ID: ENSG00000010610 Description: CD4 molecule [Source:HGNC Symbol;Acc:HGNC:1678] Location: 12:6786858-6820799 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell dendritic cell phagocyte CD4+ T cell antigen presenting cell hematopoietic cell monocyte macrophage developing T cell Regulatory T cell T cell memory T cell Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System CD40 Gene Information Basic Information Ensembl ID: ENSG00000101017 Description: CD40 molecule [Source:HGNC Symbol;Acc:HGNC:11919] Location: 20:46118271-46129863 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell dendritic cell Follicular B cell memory B cell macrophage Other: Cytokine Signaling in Immune system Adaptive Immune System CD40LG Gene Information Basic Information Ensembl ID: ENSG00000102245 Description: CD40 ligand [Source:HGNC Symbol;Acc:HGNC:11935] Location: X:136648158-136660390 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell developing T cell T cell CD4+ T cell T helper cell Other: Cytokine Signaling in Immune system Adaptive Immune System CD70 Gene Information Basic Information Ensembl ID: ENSG00000125726 Description: CD70 molecule [Source:HGNC Symbol;Acc:HGNC:11937] Location: 19:6583183-6604103 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: monocyte fibroblast memory B cell Other: Cytokine Signaling in Immune system CD80 Gene Information Basic Information Ensembl ID: ENSG00000121594 Description: CD80 molecule [Source:HGNC Symbol;Acc:HGNC:1700] Location: 3:119524293-119559614 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell Other: Cytokine Signaling in Immune system Adaptive Immune System Intracellular signaling by second messengers CD86 Gene Information Basic Information Ensembl ID: ENSG00000114013 Description: CD86 molecule [Source:HGNC Symbol;Acc:HGNC:1705] Location: 3:122055362-122121139 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell macrophage phagocyte monocyte immune cell Other: Cytokine Signaling in Immune system Adaptive Immune System Intracellular signaling by second messengers CDKN1A Gene Information Basic Information Ensembl ID: ENSG00000124762 Description: cyclin dependent kinase inhibitor 1A [Source:HGNC Symbol;Acc:HGNC:1784] Location: 6:36676460-36687397 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell pericyte dendritic cell smooth muscle cell fibroblast muscle cell monocyte Other: Cytokine Signaling in Immune system Cellular responses to stress Post-translational protein modification CHUK Gene Information Basic Information Ensembl ID: ENSG00000213341 Description: component of inhibitor of nuclear factor kappa B kinase complex [Source:HGNC Symbol;Acc:HGNC:1974] Location: 10:100188300-100229596 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Intracellular signaling by second messengers Cytokine Signaling in Immune system Adaptive Immune System CRLF2 Gene Information Basic Information Ensembl ID: ENSG00000205755 Description: cytokine receptor like factor 2 [Source:HGNC Symbol;Acc:HGNC:14281] Location: X:1190490-1212723 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: macrophage Other: Cytokine Signaling in Immune system CSF1 Gene Information Basic Information Ensembl ID: ENSG00000184371 Description: colony stimulating factor 1 [Source:HGNC Symbol;Acc:HGNC:2432] Location: 1:109910242-109930992 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell stromal cell mast cell microglia Other: MITF-M-regulated melanocyte development Cytokine Signaling in Immune system Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) CSF1R Gene Information Basic Information Ensembl ID: ENSG00000182578 Description: colony stimulating factor 1 receptor [Source:HGNC Symbol;Acc:HGNC:2433] Location: 5:150053291-150113372 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron dendritic cell macrophage phagocyte monocyte antigen presenting cell hematopoietic cell microglia Macrophage-dendritic cell progenitor Other: Cytokine Signaling in Immune system RNA Polymerase II Transcription CSF2 Gene Information Basic Information Ensembl ID: ENSG00000164400 Description: colony stimulating factor 2 [Source:HGNC Symbol;Acc:HGNC:2434] Location: 5:132073789-132076170 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system MAPK family signaling cascades RNA Polymerase II Transcription CSF2RA Gene Information Basic Information Ensembl ID: ENSG00000198223 Description: colony stimulating factor 2 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:2435] Location: X:1268793-1325373 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron dendritic cell macrophage phagocyte microglia monocyte antigen presenting cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades Surfactant metabolism CSF2RB Gene Information Basic Information Ensembl ID: ENSG00000100368 Description: colony stimulating factor 2 receptor subunit beta [Source:HGNC Symbol;Acc:HGNC:2436] Location: 22:36913628-36940439 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell dendritic cell mast cell antigen presenting cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades Surfactant metabolism CSF3R Gene Information Basic Information Ensembl ID: ENSG00000119535 Description: colony stimulating factor 3 receptor [Source:HGNC Symbol;Acc:HGNC:2439] Location: 1:36466043-36483278 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell trophoblast cell phagocyte microglia granulocyte monocyte neutrophil myeloid cell Other: Cytokine Signaling in Immune system Transcriptional regulation of granulopoiesis CXCL10 Gene Information Basic Information Ensembl ID: ENSG00000169245 Description: C-X-C motif chemokine ligand 10 [Source:HGNC Symbol;Acc:HGNC:10637] Location: 4:76021118-76023497 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: monocyte phagocyte Other: Cytokine Signaling in Immune system Signaling by GPCR DUSP4 Gene Information Basic Information Ensembl ID: ENSG00000120875 Description: dual specificity phosphatase 4 [Source:HGNC Symbol;Acc:HGNC:3070] Location: 8:29333064-29350684 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell developing T cell Regulatory T cell Specialized T cell autonomic neuron Other: Cytokine Signaling in Immune system Innate Immune System MAPK family signaling cascades DUSP6 Gene Information Basic Information Ensembl ID: ENSG00000139318 Description: dual specificity phosphatase 6 [Source:HGNC Symbol;Acc:HGNC:3072] Location: 12:89347235-89352501 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell endothelial cell phagocyte mast cell monocyte granulocyte myeloid cell innate lymphoid cell Other: Cytokine Signaling in Immune system Innate Immune System MAPK family signaling cascades FASLG Gene Information Basic Information Ensembl ID: ENSG00000117560 Description: Fas ligand [Source:HGNC Symbol;Acc:HGNC:11936] Location: 1:172659103-172666876 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell T cell Specialized T cell CD8+ T cell Other: Apoptosis Cytokine Signaling in Immune system Regulated Necrosis FCER2 Gene Information Basic Information Ensembl ID: ENSG00000104921 Description: Fc epsilon receptor II [Source:HGNC Symbol;Acc:HGNC:3612] Location: 19:7688758-7702146 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell Follicular B cell dendritic cell Other: Cytokine Signaling in Immune system Signaling by NOTCH FGF2 Gene Information Basic Information Ensembl ID: ENSG00000138685 Description: fibroblast growth factor 2 [Source:HGNC Symbol;Acc:HGNC:3676] Location: 4:122826682-122898236 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: fibroblast glial cell adipocyte Other: Non-integrin membrane-ECM interactions Cytokine Signaling in Immune system Transcriptional regulation of pluripotent stem cells FLT3 Gene Information Basic Information Ensembl ID: ENSG00000122025 Description: fms related receptor tyrosine kinase 3 [Source:HGNC Symbol;Acc:HGNC:3765] Location: 13:28003274-28100592 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell Other: MAPK family signaling cascades Cytokine Signaling in Immune system Intracellular signaling by second messengers FN1 Gene Information Basic Information Ensembl ID: ENSG00000115414 Description: fibronectin 1 [Source:HGNC Symbol;Acc:HGNC:3778] Location: 2:215360440-215436073 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell fibroblast endocrine cell pericyte epithelial cell stellate cell stem cell phagocyte muscle cell stromal cell smooth muscle cell thymic epithelial cell skeletal muscle cell mesenchymal cell Other: Cytokine Signaling in Immune system Degradation of the extracellular matrix Elastic fibre formation FYN Gene Information Basic Information Ensembl ID: ENSG00000010810 Description: FYN proto-oncogene%2C Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:4037] Location: 6:111660332-111873452 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Cellular responses to mechanical stimuli GATA3 Gene Information Basic Information Ensembl ID: ENSG00000107485 Description: GATA binding protein 3 [Source:HGNC Symbol;Acc:HGNC:4172] Location: 10:8045378-8075198 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell epithelial cell trophoblast cell developing T cell Regulatory T cell phagocyte natural killer cell CD4+ T cell lymphocyte innate lymphoid cell T helper cell neuron Other: Cytokine Signaling in Immune system Post-translational protein modification RNA Polymerase II Transcription GHR Gene Information Basic Information Ensembl ID: ENSG00000112964 Description: growth hormone receptor [Source:HGNC Symbol;Acc:HGNC:4263] Location: 5:42423439-42721878 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system HAVCR2 Gene Information Basic Information Ensembl ID: ENSG00000135077 Description: hepatitis A virus cellular receptor 2 [Source:HGNC Symbol;Acc:HGNC:18437] Location: 5:157085422-157142869 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron natural killer cell macrophage phagocyte microglia Specialized T cell CD8+ T cell T cell antigen presenting cell dendritic cell Other: Cytokine Signaling in Immune system HGF Gene Information Basic Information Ensembl ID: ENSG00000019991 Description: hepatocyte growth factor [Source:HGNC Symbol;Acc:HGNC:4893] Location: 7:81699010-81770438 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stellate cell fibroblast stromal cell bone cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades Platelet activation, signaling and aggregation HIF1A Gene Information Basic Information Ensembl ID: ENSG00000100644 Description: hypoxia inducible factor 1 subunit alpha [Source:HGNC Symbol;Acc:HGNC:4910] Location: 14:61695513-61748259 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell macrophage phagocyte microglia granulocyte monocyte myeloid cell antigen presenting cell innate lymphoid cell dendritic cell Other: Cytokine Signaling in Immune system Signaling by NOTCH Cellular responses to stress HLA-DQA1 Gene Information Basic Information Ensembl ID: ENSG00000196735 Description: major histocompatibility complex%2C class II%2C DQ alpha 1 [Source:HGNC Symbol;Acc:HGNC:4942] Location: 6:32628179-32647062 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell macrophage Naive B cell phagocyte Follicular B cell antigen presenting cell monocyte Other: Cytokine Signaling in Immune system Adaptive Immune System HLA-DQB1 Gene Information Basic Information Ensembl ID: ENSG00000179344 Description: major histocompatibility complex%2C class II%2C DQ beta 1 [Source:HGNC Symbol;Acc:HGNC:4944] Location: 6:32659467-32668383 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell macrophage thymic epithelial cell Naive B cell phagocyte Follicular B cell antigen presenting cell monocyte Other: Cytokine Signaling in Immune system HRAS Gene Information Basic Information Ensembl ID: ENSG00000174775 Description: HRas proto-oncogene%2C GTPase [Source:HGNC Symbol;Acc:HGNC:5173] Location: 11:532242-537321 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Transmission across Chemical Synapses Cytokine Signaling in Immune system Adaptive Immune System ICAM1 Gene Information Basic Information Ensembl ID: ENSG00000090339 Description: intercellular adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:5344] Location: 19:10271093-10286615 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell endothelial cell natural killer cell dendritic cell phagocyte stromal cell pancreatic cell granulocyte macrophage kupffer cell fibroblast Other: Cytokine Signaling in Immune system Adaptive Immune System Integrin cell surface interactions IFIH1 Gene Information Basic Information Ensembl ID: ENSG00000115267 Description: interferon induced with helicase C domain 1 [Source:HGNC Symbol;Acc:HGNC:18873] Location: 2:162267074-162318684 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: antigen presenting cell Other: Cytokine Signaling in Immune system Innate Immune System Post-translational protein modification IFIT1 Gene Information Basic Information Ensembl ID: ENSG00000185745 Description: interferon induced protein with tetratricopeptide repeats 1 [Source:HGNC Symbol;Acc:HGNC:5407] Location: 10:89392546-89406487 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: phagocyte fibroblast macrophage Other: Cytokine Signaling in Immune system IFNAR1 Gene Information Basic Information Ensembl ID: ENSG00000142166 Description: interferon alpha and beta receptor subunit 1 [Source:HGNC Symbol;Acc:HGNC:5432] Location: 21:33324387-33359864 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Viral Infection Pathways IFNAR2 Gene Information Basic Information Ensembl ID: ENSG00000159110 Description: interferon alpha and beta receptor subunit 2 [Source:HGNC Symbol;Acc:HGNC:5433] Location: 21:33205282-33265675 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Regulatory T cell endothelial cell Other: Cytokine Signaling in Immune system Viral Infection Pathways IFNB1 Gene Information Basic Information Ensembl ID: ENSG00000171855 Description: interferon beta 1 [Source:HGNC Symbol;Acc:HGNC:5434] Location: 9:21077104-21077942 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Innate Immune System Cellular responses to stress IFNG Gene Information Basic Information Ensembl ID: ENSG00000111537 Description: interferon gamma [Source:HGNC Symbol;Acc:HGNC:5438] Location: 12:68154768-68159740 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell memory T cell T cell Specialized T cell CD8+ T cell developing T cell Other: Cytokine Signaling in Immune system RNA Polymerase II Transcription IFNGR1 Gene Information Basic Information Ensembl ID: ENSG00000027697 Description: interferon gamma receptor 1 [Source:HGNC Symbol;Acc:HGNC:5439] Location: 6:137197483-137219449 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell neuron dendritic cell macrophage phagocyte monocyte Other: Cytokine Signaling in Immune system Viral Infection Pathways IFNGR2 Gene Information Basic Information Ensembl ID: ENSG00000159128 Description: interferon gamma receptor 2 [Source:HGNC Symbol;Acc:HGNC:5440] Location: 21:33403413-33479348 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: phagocyte granulocyte monocyte schwann cell adipocyte Other: Cytokine Signaling in Immune system Viral Infection Pathways IKBKB Gene Information Basic Information Ensembl ID: ENSG00000104365 Description: inhibitor of nuclear factor kappa B kinase subunit beta [Source:HGNC Symbol;Acc:HGNC:5960] Location: 8:42271302-42332460 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell secretory cell T cell Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System IL10 Gene Information Basic Information Ensembl ID: ENSG00000136634 Description: interleukin 10 [Source:HGNC Symbol;Acc:HGNC:5962] Location: 1:206767602-206774541 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell Specialized T cell CD4+ T cell monocyte Naive B cell Regulatory T cell Other: Cytokine Signaling in Immune system Signaling by ALK in cancer Parasitic Infection Pathways IL10RA Gene Information Basic Information Ensembl ID: ENSG00000110324 Description: interleukin 10 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:5964] Location: 11:117986370-118003037 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell Regulatory T cell leukocyte hematopoietic cell macrophage innate lymphoid cell Other: Cytokine Signaling in Immune system Signaling by ALK in cancer IL11 Gene Information Basic Information Ensembl ID: ENSG00000095752 Description: interleukin 11 [Source:HGNC Symbol;Acc:HGNC:5966] Location: 19:55364382-55370463 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system IL11RA Gene Information Basic Information Ensembl ID: ENSG00000137070 Description: interleukin 11 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:5967] Location: 9:34652162-34661902 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stem cell fibroblast glial cell stromal cell epithelial cell mesenchymal cell endothelial cell Other: Cytokine Signaling in Immune system IL12A Gene Information Basic Information Ensembl ID: ENSG00000168811 Description: interleukin 12A [Source:HGNC Symbol;Acc:HGNC:5969] Location: 3:159988835-159996019 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system IL12B Gene Information Basic Information Ensembl ID: ENSG00000113302 Description: interleukin 12B [Source:HGNC Symbol;Acc:HGNC:5970] Location: 5:159314780-159330863 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system IL12RB1 Gene Information Basic Information Ensembl ID: ENSG00000096996 Description: interleukin 12 receptor subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:5971] Location: 19:18058995-18098944 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system IL12RB2 Gene Information Basic Information Ensembl ID: ENSG00000081985 Description: interleukin 12 receptor subunit beta 2 [Source:HGNC Symbol;Acc:HGNC:5972] Location: 1:67307364-67398724 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell Specialized T cell Other: Cytokine Signaling in Immune system IL13 Gene Information Basic Information Ensembl ID: ENSG00000169194 Description: interleukin 13 [Source:HGNC Symbol;Acc:HGNC:5973] Location: 5:132656263-132661110 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: CD4+ T cell Other: Cytokine Signaling in Immune system IL13RA1 Gene Information Basic Information Ensembl ID: ENSG00000131724 Description: interleukin 13 receptor subunit alpha 1 [Source:HGNC Symbol;Acc:HGNC:5974] Location: X:118727133-118794535 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell tuft cell Other: Cytokine Signaling in Immune system IL13RA2 Gene Information Basic Information Ensembl ID: ENSG00000123496 Description: interleukin 13 receptor subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:5975] Location: X:115003975-115019977 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell Other: Cytokine Signaling in Immune system IL15 Gene Information Basic Information Ensembl ID: ENSG00000164136 Description: interleukin 15 [Source:HGNC Symbol;Acc:HGNC:5977] Location: 4:141636583-141733987 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell Other: Cytokine Signaling in Immune system IL15RA Gene Information Basic Information Ensembl ID: ENSG00000134470 Description: interleukin 15 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:5978] Location: 10:5943639-5978187 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system IL16 Gene Information Basic Information Ensembl ID: ENSG00000172349 Description: interleukin 16 [Source:HGNC Symbol;Acc:HGNC:5980] Location: 15:81159575-81314058 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: CD4+ T cell fibroblast CD8+ T cell Follicular B cell innate lymphoid cell lymphocyte Other: Cytokine Signaling in Immune system IL17A Gene Information Basic Information Ensembl ID: ENSG00000112115 Description: interleukin 17A [Source:HGNC Symbol;Acc:HGNC:5981] Location: 6:52186375-52190638 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Viral Infection Pathways IL17RA Gene Information Basic Information Ensembl ID: ENSG00000177663 Description: interleukin 17 receptor A [Source:HGNC Symbol;Acc:HGNC:5985] Location: 22:17084954-17115693 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: granulocyte basophil Other: Cytokine Signaling in Immune system Viral Infection Pathways IL17RB Gene Information Basic Information Ensembl ID: ENSG00000056736 Description: interleukin 17 receptor B [Source:HGNC Symbol;Acc:HGNC:18015] Location: 3:53846568-53865794 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: tuft cell Other: Cytokine Signaling in Immune system IL18 Gene Information Basic Information Ensembl ID: ENSG00000150782 Description: interleukin 18 [Source:HGNC Symbol;Acc:HGNC:5986] Location: 11:112143251-112164096 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: kidney cell dendritic cell macrophage hematopoietic stem cell phagocyte stem cell leukocyte epithelial cell mast cell myeloid cell antigen presenting cell pneumocyte progenitor cell neutrophil monocyte Other: Cytokine Signaling in Immune system Regulated Necrosis Parasitic Infection Pathways IL18R1 Gene Information Basic Information Ensembl ID: ENSG00000115604 Description: interleukin 18 receptor 1 [Source:HGNC Symbol;Acc:HGNC:5988] Location: 2:102311529-102398777 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell mast cell granulocyte basophil innate lymphoid cell Other: Cytokine Signaling in Immune system IL19 Gene Information Basic Information Ensembl ID: ENSG00000142224 Description: interleukin 19 [Source:HGNC Symbol;Acc:HGNC:5990] Location: 1:206770764-206842981 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system IL1A Gene Information Basic Information Ensembl ID: ENSG00000115008 Description: interleukin 1 alpha [Source:HGNC Symbol;Acc:HGNC:5991] Location: 2:112773925-112784493 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell Other: Cytokine Signaling in Immune system Cellular responses to stress Regulated Necrosis IL1B Gene Information Basic Information Ensembl ID: ENSG00000125538 Description: interleukin 1 beta [Source:HGNC Symbol;Acc:HGNC:5992] Location: 2:112829751-112836816 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell neuron macrophage dendritic cell phagocyte monocyte progenitor cell myeloid cell antigen presenting cell Other: Regulated Necrosis Cytokine Signaling in Immune system Innate Immune System IL1R1 Gene Information Basic Information Ensembl ID: ENSG00000115594 Description: interleukin 1 receptor type 1 [Source:HGNC Symbol;Acc:HGNC:5993] Location: 2:102064544-102179874 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell blood cell fibroblast trophoblast cell stromal cell granulocyte epithelial cell neutrophil innate lymphoid cell Other: Cytokine Signaling in Immune system Viral Infection Pathways IL1RAP Gene Information Basic Information Ensembl ID: ENSG00000196083 Description: interleukin 1 receptor accessory protein [Source:HGNC Symbol;Acc:HGNC:5995] Location: 3:190514051-190659750 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell hepatocyte sensory neuron neuron granulocyte cancer stem cell Other: Cytokine Signaling in Immune system Protein-protein interactions at synapses Intracellular signaling by second messengers IL1RL1 Gene Information Basic Information Ensembl ID: ENSG00000115602 Description: interleukin 1 receptor like 1 [Source:HGNC Symbol;Acc:HGNC:5998] Location: 2:102311502-102352037 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell endothelial cell mast cell lymphocyte Other: Cytokine Signaling in Immune system Intracellular signaling by second messengers IL1RN Gene Information Basic Information Ensembl ID: ENSG00000136689 Description: interleukin 1 receptor antagonist [Source:HGNC Symbol;Acc:HGNC:6000] Location: 2:113099315-113134016 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell dendritic cell phagocyte stem cell epithelial cell monocyte granulocyte macrophage Other: Cytokine Signaling in Immune system IL2 Gene Information Basic Information Ensembl ID: ENSG00000109471 Description: interleukin 2 [Source:HGNC Symbol;Acc:HGNC:6001] Location: 4:122451470-122456725 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: CD4+ T cell innate lymphoid cell CD8+ T cell developing T cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades RNA Polymerase II Transcription IL21 Gene Information Basic Information Ensembl ID: ENSG00000138684 Description: interleukin 21 [Source:HGNC Symbol;Acc:HGNC:6005] Location: 4:122610108-122621066 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: CD4+ T cell T helper cell Other: Cytokine Signaling in Immune system IL21R Gene Information Basic Information Ensembl ID: ENSG00000103522 Description: interleukin 21 receptor [Source:HGNC Symbol;Acc:HGNC:6006] Location: 16:27402174-27452042 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Regulatory T cell Other: Cytokine Signaling in Immune system IL22RA1 Gene Information Basic Information Ensembl ID: ENSG00000142677 Description: interleukin 22 receptor subunit alpha 1 [Source:HGNC Symbol;Acc:HGNC:13700] Location: 1:24119771-24143140 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system IL22RA2 Gene Information Basic Information Ensembl ID: ENSG00000164485 Description: interleukin 22 receptor subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:14901] Location: 6:137143820-137173648 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system IL23A Gene Information Basic Information Ensembl ID: ENSG00000110944 Description: interleukin 23 subunit alpha [Source:HGNC Symbol;Acc:HGNC:15488] Location: 12:56334174-56340410 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: macrophage Other: Cytokine Signaling in Immune system IL23R Gene Information Basic Information Ensembl ID: ENSG00000162594 Description: interleukin 23 receptor [Source:HGNC Symbol;Acc:HGNC:19100] Location: 1:67138907-67259979 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: innate lymphoid cell Other: Cytokine Signaling in Immune system IL24 Gene Information Basic Information Ensembl ID: ENSG00000162892 Description: interleukin 24 [Source:HGNC Symbol;Acc:HGNC:11346] Location: 1:206897443-206904139 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: fibroblast Other: Cytokine Signaling in Immune system IL27RA Gene Information Basic Information Ensembl ID: ENSG00000104998 Description: interleukin 27 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:17290] Location: 19:14031762-14053218 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: CD4+ T cell Other: Cytokine Signaling in Immune system IL2RA Gene Information Basic Information Ensembl ID: ENSG00000134460 Description: interleukin 2 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:6008] Location: 10:6010689-6062370 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Regulatory T cell macrophage dendritic cell developing T cell B cell mast cell CD8+ T cell T cell Follicular B cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades RNA Polymerase II Transcription IL2RB Gene Information Basic Information Ensembl ID: ENSG00000100385 Description: interleukin 2 receptor subunit beta [Source:HGNC Symbol;Acc:HGNC:6009] Location: 22:37118666-37175118 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell developing T cell T cell Specialized T cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades IL2RG Gene Information Basic Information Ensembl ID: ENSG00000147168 Description: interleukin 2 receptor subunit gamma [Source:HGNC Symbol;Acc:HGNC:6010] Location: X:71107404-71112108 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell CD8+ T cell developing T cell T cell Regulatory T cell leukocyte Specialized T cell lymphocyte Other: Cytokine Signaling in Immune system MAPK family signaling cascades Signaling by Receptor Tyrosine Kinases IL34 Gene Information Basic Information Ensembl ID: ENSG00000157368 Description: interleukin 34 [Source:HGNC Symbol;Acc:HGNC:28529] Location: 16:70579895-70660682 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte mural cell Other: Cytokine Signaling in Immune system IL3RA Gene Information Basic Information Ensembl ID: ENSG00000185291 Description: interleukin 3 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:6012] Location: X:1336616-1382689 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell enteroendocrine cell endothelial cell dendritic cell progenitor bone cell basophil antigen presenting cell plasma cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades IL4 Gene Information Basic Information Ensembl ID: ENSG00000113520 Description: interleukin 4 [Source:HGNC Symbol;Acc:HGNC:6014] Location: 5:132673986-132682678 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: basophil Other: Cytokine Signaling in Immune system IL4R Gene Information Basic Information Ensembl ID: ENSG00000077238 Description: interleukin 4 receptor [Source:HGNC Symbol;Acc:HGNC:6015] Location: 16:27313668-27364778 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell fibroblast Naive B cell Other: Cytokine Signaling in Immune system IL5RA Gene Information Basic Information Ensembl ID: ENSG00000091181 Description: interleukin 5 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:6017] Location: 3:3066324-3126613 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: mast cell eosinophil Other: Cytokine Signaling in Immune system MAPK family signaling cascades IL6 Gene Information Basic Information Ensembl ID: ENSG00000136244 Description: interleukin 6 [Source:HGNC Symbol;Acc:HGNC:6018] Location: 7:22725884-22732002 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte endothelial cell stromal cell smooth muscle cell CD4+ T cell vascular cell immune cell Other: Cytokine Signaling in Immune system Cellular responses to stress Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) IL6R Gene Information Basic Information Ensembl ID: ENSG00000160712 Description: interleukin 6 receptor [Source:HGNC Symbol;Acc:HGNC:6019] Location: 1:154405193-154469450 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: CD4+ T cell neutrophil Other: Cytokine Signaling in Immune system MAPK family signaling cascades Transcriptional regulation of granulopoiesis IL6ST Gene Information Basic Information Ensembl ID: ENSG00000134352 Description: interleukin 6 cytokine family signal transducer [Source:HGNC Symbol;Acc:HGNC:6021] Location: 5:55935095-55995022 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell stromal cell pericyte stem cell fibroblast epithelial cell interstitial cell developing T cell mesenchymal stem cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades IL7 Gene Information Basic Information Ensembl ID: ENSG00000104432 Description: interleukin 7 [Source:HGNC Symbol;Acc:HGNC:6023] Location: 8:78675743-78805523 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell neuron Other: Cytokine Signaling in Immune system IL9R Gene Information Basic Information Ensembl ID: ENSG00000124334 Description: interleukin 9 receptor [Source:HGNC Symbol;Acc:HGNC:6030] Location: X:155997696-156013017 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system IRAK1 Gene Information Basic Information Ensembl ID: ENSG00000184216 Description: interleukin 1 receptor associated kinase 1 [Source:HGNC Symbol;Acc:HGNC:6112] Location: X:154010506-154019902 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: monocyte Other: Cytokine Signaling in Immune system Innate Immune System RNA Polymerase II Transcription IRAK2 Gene Information Basic Information Ensembl ID: ENSG00000134070 Description: interleukin 1 receptor associated kinase 2 [Source:HGNC Symbol;Acc:HGNC:6113] Location: 3:10164919-10243745 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell granulocyte Other: Cytokine Signaling in Immune system Innate Immune System Viral Infection Pathways IRAK3 Gene Information Basic Information Ensembl ID: ENSG00000090376 Description: interleukin 1 receptor associated kinase 3 [Source:HGNC Symbol;Acc:HGNC:17020] Location: 12:66189195-66254622 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell macrophage phagocyte monocyte granulocyte neutrophil antigen presenting cell Other: Cytokine Signaling in Immune system Innate Immune System IRAK4 Gene Information Basic Information Ensembl ID: ENSG00000198001 Description: interleukin 1 receptor associated kinase 4 [Source:HGNC Symbol;Acc:HGNC:17967] Location: 12:43758944-43798307 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Innate Immune System Intracellular signaling by second messengers IRF2 Gene Information Basic Information Ensembl ID: ENSG00000168310 Description: interferon regulatory factor 2 [Source:HGNC Symbol;Acc:HGNC:6117] Location: 4:184385702-184474558 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Regulated Necrosis Factors involved in megakaryocyte development and platelet production IRF3 Gene Information Basic Information Ensembl ID: ENSG00000126456 Description: interferon regulatory factor 3 [Source:HGNC Symbol;Acc:HGNC:6118] Location: 19:49659569-49665875 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Innate Immune System Viral Infection Pathways IRF4 Gene Information Basic Information Ensembl ID: ENSG00000137265 Description: interferon regulatory factor 4 [Source:HGNC Symbol;Acc:HGNC:6119] Location: 6:391739-411443 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell dendritic cell plasma cell antigen presenting cell lymphocyte plasmablast Other: Cytokine Signaling in Immune system MITF-M-regulated melanocyte development Signaling by ALK in cancer IRF5 Gene Information Basic Information Ensembl ID: ENSG00000128604 Description: interferon regulatory factor 5 [Source:HGNC Symbol;Acc:HGNC:6120] Location: 7:128937457-128950038 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Innate Immune System IRF8 Gene Information Basic Information Ensembl ID: ENSG00000140968 Description: interferon regulatory factor 8 [Source:HGNC Symbol;Acc:HGNC:5358] Location: 16:85899116-85922606 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell Naive B cell phagocyte Follicular B cell antigen presenting cell Other: Cytokine Signaling in Immune system IRS1 Gene Information Basic Information Ensembl ID: ENSG00000169047 Description: insulin receptor substrate 1 [Source:HGNC Symbol;Acc:HGNC:6125] Location: 2:226731312-226799820 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Signaling by Leptin MAPK family signaling cascades ITGAM Gene Information Basic Information Ensembl ID: ENSG00000169896 Description: integrin subunit alpha M [Source:HGNC Symbol;Acc:HGNC:6149] Location: 16:31259967-31332892 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: granulocyte hematopoietic cell dendritic cell myeloid derived suppressor cell monocyte eosinophil neutrophil Other: Cytokine Signaling in Immune system Innate Immune System Cell surface interactions at the vascular wall ITGAX Gene Information Basic Information Ensembl ID: ENSG00000140678 Description: integrin subunit alpha X [Source:HGNC Symbol;Acc:HGNC:6152] Location: 16:31355134-31382999 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell natural killer cell phagocyte mast cell monocyte granulocyte dendritic cell Other: Cytokine Signaling in Immune system Innate Immune System Cell surface interactions at the vascular wall ITGB1 Gene Information Basic Information Ensembl ID: ENSG00000150093 Description: integrin subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:6153] Location: 10:32887273-33005792 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stellate cell pericyte trophoblast cell epithelial cell stromal cell stem cell endothelial cell smooth muscle cell fibroblast mesenchymal stem cell Other: Laminin interactions Cell surface interactions at the vascular wall Cytokine Signaling in Immune system ITGB2 Gene Information Basic Information Ensembl ID: ENSG00000160255 Description: integrin subunit beta 2 [Source:HGNC Symbol;Acc:HGNC:6155] Location: 21:44885953-44931989 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell natural killer cell memory T cell developing T cell macrophage dendritic cell phagocyte leukocyte T cell Specialized T cell monocyte Other: Adaptive Immune System Cytokine Signaling in Immune system Innate Immune System JAK2 Gene Information Basic Information Ensembl ID: ENSG00000096968 Description: Janus kinase 2 [Source:HGNC Symbol;Acc:HGNC:6192] Location: 9:4984390-5129948 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: fibroblast basophil dendritic cell Other: Chromatin modifying enzymes Cytokine Signaling in Immune system Signaling by Leptin JAK3 Gene Information Basic Information Ensembl ID: ENSG00000105639 Description: Janus kinase 3 [Source:HGNC Symbol;Acc:HGNC:6193] Location: 19:17824780-17848071 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Specialized T cell CD4+ T cell T cell CD8+ T cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades Signaling by Receptor Tyrosine Kinases KRAS Gene Information Basic Information Ensembl ID: ENSG00000133703 Description: KRAS proto-oncogene%2C GTPase [Source:HGNC Symbol;Acc:HGNC:6407] Location: 12:25205246-25250936 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Signaling by Non-Receptor Tyrosine Kinases Transmission across Chemical Synapses Cytokine Signaling in Immune system LCK Gene Information Basic Information Ensembl ID: ENSG00000182866 Description: LCK proto-oncogene%2C Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6524] Location: 1:32251244-32286165 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell CD8+ T cell developing T cell T cell lymphocyte Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System LIF Gene Information Basic Information Ensembl ID: ENSG00000128342 Description: LIF interleukin 6 family cytokine [Source:HGNC Symbol;Acc:HGNC:6596] Location: 22:30240453-30246759 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell epithelial cell fibroblast mast cell Other: Cytokine Signaling in Immune system LYN Gene Information Basic Information Ensembl ID: ENSG00000254087 Description: LYN proto-oncogene%2C Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6735] Location: 8:55879835-56014169 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System MAP2K1 Gene Information Basic Information Ensembl ID: ENSG00000169032 Description: mitogen-activated protein kinase kinase 1 [Source:HGNC Symbol;Acc:HGNC:6840] Location: 15:66386837-66491656 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Innate Immune System MAPK family signaling cascades MAP2K4 Gene Information Basic Information Ensembl ID: ENSG00000065559 Description: mitogen-activated protein kinase kinase 4 [Source:HGNC Symbol;Acc:HGNC:6844] Location: 17:12020829-12143830 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stem cell Other: Cytokine Signaling in Immune system Innate Immune System Cellular responses to stress MAPK1 Gene Information Basic Information Ensembl ID: ENSG00000100030 Description: mitogen-activated protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:6871] Location: 22:21759657-21867680 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Transmission across Chemical Synapses Signaling by NODAL MAPK14 Gene Information Basic Information Ensembl ID: ENSG00000112062 Description: mitogen-activated protein kinase 14 [Source:HGNC Symbol;Acc:HGNC:6876] Location: 6:36027752-36122511 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Platelet homeostasis Cytokine Signaling in Immune system Mitochondrial biogenesis MAPK3 Gene Information Basic Information Ensembl ID: ENSG00000102882 Description: mitogen-activated protein kinase 3 [Source:HGNC Symbol;Acc:HGNC:6877] Location: 16:30114105-30123506 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Transmission across Chemical Synapses Signaling by NODAL MAPK8 Gene Information Basic Information Ensembl ID: ENSG00000107643 Description: mitogen-activated protein kinase 8 [Source:HGNC Symbol;Acc:HGNC:6881] Location: 10:48306639-48439360 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System MMP2 Gene Information Basic Information Ensembl ID: ENSG00000087245 Description: matrix metallopeptidase 2 [Source:HGNC Symbol;Acc:HGNC:7166] Location: 16:55389700-55506691 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: mesenchymal cell smooth muscle cell Other: Cytokine Signaling in Immune system Degradation of the extracellular matrix Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MMP9 Gene Information Basic Information Ensembl ID: ENSG00000100985 Description: matrix metallopeptidase 9 [Source:HGNC Symbol;Acc:HGNC:7176] Location: 20:46008908-46016561 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell macrophage phagocyte neutrophil monocyte osteoclast Other: Cytokine Signaling in Immune system Degradation of the extracellular matrix Collagen formation MUC1 Gene Information Basic Information Ensembl ID: ENSG00000185499 Description: mucin 1%2C cell surface associated [Source:HGNC Symbol;Acc:HGNC:7508] Location: 1:155185824-155192916 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell pneumocyte goblet cell enterocyte secretory cell cancer cell Other: Cytokine Signaling in Immune system Innate Immune System Post-translational protein modification MX1 Gene Information Basic Information Ensembl ID: ENSG00000157601 Description: MX dynamin like GTPase 1 [Source:HGNC Symbol;Acc:HGNC:7532] Location: 21:41420020-41470071 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system MYC Gene Information Basic Information Ensembl ID: ENSG00000136997 Description: MYC proto-oncogene%2C bHLH transcription factor [Source:HGNC Symbol;Acc:HGNC:7553] Location: 8:127735434-127742951 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte epithelial cell fibroblast stromal cell smooth muscle cell hematopoietic progenitor cell endothelial cell stem cell erythroblast muscle cell progenitor cell transient amplifying cell cancer stem cell B cell erythroid lineage cell Other: Cytokine Signaling in Immune system Signaling by NOTCH Signaling by WNT MYD88 Gene Information Basic Information Ensembl ID: ENSG00000172936 Description: MYD88 innate immune signal transduction adaptor [Source:HGNC Symbol;Acc:HGNC:7562] Location: 3:38138552-38143024 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: monocyte Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System NCAM1 Gene Information Basic Information Ensembl ID: ENSG00000149294 Description: neural cell adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:7656] Location: 11:112961275-113278436 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron natural killer cell interneuron pericyte T cell glial cell smooth muscle cell motor neuron Specialized T cell innate lymphoid cell chromaffin cell epithelial cell neuroendocrine cell lymphocyte cancer stem cell progenitor cell stem cell mesenchymal stem cell immune cell cancer cell autonomic neuron Other: ECM proteoglycans Cytokine Signaling in Immune system MAPK family signaling cascades NFKB1 Gene Information Basic Information Ensembl ID: ENSG00000109320 Description: nuclear factor kappa B subunit 1 [Source:HGNC Symbol;Acc:HGNC:7794] Location: 4:102501330-102617302 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System NFKB2 Gene Information Basic Information Ensembl ID: ENSG00000077150 Description: nuclear factor kappa B subunit 2 [Source:HGNC Symbol;Acc:HGNC:7795] Location: 10:102394110-102402524 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: CD4+ T cell Other: Cytokine Signaling in Immune system Innate Immune System Chromatin modifying enzymes NLRC5 Gene Information Basic Information Ensembl ID: ENSG00000140853 Description: NLR family CARD domain containing 5 [Source:HGNC Symbol;Acc:HGNC:29933] Location: 16:56989485-57083531 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: CD8+ T cell developing T cell T cell Other: Cytokine Signaling in Immune system Innate Immune System NOS2 Gene Information Basic Information Ensembl ID: ENSG00000007171 Description: nitric oxide synthase 2 [Source:HGNC Symbol;Acc:HGNC:7873] Location: 17:27756766-27800529 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Innate Immune System Platelet homeostasis NRAS Gene Information Basic Information Ensembl ID: ENSG00000213281 Description: NRAS proto-oncogene%2C GTPase [Source:HGNC Symbol;Acc:HGNC:7989] Location: 1:114704469-114716771 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell cancer cell Other: Signaling by Erythropoietin Signaling by Non-Receptor Tyrosine Kinases Signaling by Nuclear Receptors OAS3 Gene Information Basic Information Ensembl ID: ENSG00000111331 Description: 2'-5'-oligoadenylate synthetase 3 [Source:HGNC Symbol;Acc:HGNC:8088] Location: 12:112938051-112976460 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: macrophage Other: Cytokine Signaling in Immune system OSM Gene Information Basic Information Ensembl ID: ENSG00000099985 Description: oncostatin M [Source:HGNC Symbol;Acc:HGNC:8506] Location: 22:30262829-30266851 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell granulocyte basophil Other: Cytokine Signaling in Immune system PIK3CA Gene Information Basic Information Ensembl ID: ENSG00000121879 Description: phosphatidylinositol-4%2C5-bisphosphate 3-kinase catalytic subunit alpha [Source:HGNC Symbol;Acc:HGNC:8975] Location: 3:179148114-179240093 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System PIK3CD Gene Information Basic Information Ensembl ID: ENSG00000171608 Description: phosphatidylinositol-4%2C5-bisphosphate 3-kinase catalytic subunit delta [Source:HGNC Symbol;Acc:HGNC:8977] Location: 1:9629889-9729114 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: developing T cell T cell hematopoietic cell Other: Cytokine Signaling in Immune system Adaptive Immune System Metabolism of lipids PTGS2 Gene Information Basic Information Ensembl ID: ENSG00000073756 Description: prostaglandin-endoperoxide synthase 2 [Source:HGNC Symbol;Acc:HGNC:9605] Location: 1:186671791-186680922 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell endothelial cell fibroblast macrophage phagocyte mast cell granulocyte dendritic cell monocyte epithelial cell Other: Cytokine Signaling in Immune system Metabolism of lipids PTPN11 Gene Information Basic Information Ensembl ID: ENSG00000179295 Description: protein tyrosine phosphatase non-receptor type 11 [Source:HGNC Symbol;Acc:HGNC:9644] Location: 12:112418351-112509918 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System RELA Gene Information Basic Information Ensembl ID: ENSG00000173039 Description: RELA proto-oncogene%2C NF-kB subunit [Source:HGNC Symbol;Acc:HGNC:9955] Location: 11:65653599-65663090 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System RIGI Gene Information Basic Information Ensembl ID: ENSG00000107201 Description: RNA sensor RIG-I [Source:HGNC Symbol;Acc:HGNC:19102] Location: 9:32455302-32526348 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Innate Immune System Post-translational protein modification RORC Gene Information Basic Information Ensembl ID: ENSG00000143365 Description: RAR related orphan receptor C [Source:HGNC Symbol;Acc:HGNC:10260] Location: 1:151806071-151831845 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: CD4+ T cell T cell innate lymphoid cell Specialized T cell Other: Cytokine Signaling in Immune system RNA Polymerase II Transcription Expression of BMAL (ARNTL), CLOCK, and NPAS2 SMAD3 Gene Information Basic Information Ensembl ID: ENSG00000166949 Description: SMAD family member 3 [Source:HGNC Symbol;Acc:HGNC:6769] Location: 15:67063763-67195173 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell stem cell mesenchymal cell Other: Signaling by NODAL Cytokine Signaling in Immune system Signaling by NOTCH SMARCA4 Gene Information Basic Information Ensembl ID: ENSG00000127616 Description: SWI/SNF related%2C matrix associated%2C actin dependent regulator of chromatin%2C subfamily a%2C member 4 [Source:HGNC Symbol;Acc:HGNC:11100] Location: 19:10960932-11079426 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell epithelial cell fibroblast Other: Cytokine Signaling in Immune system Signaling by WNT Epigenetic regulation of gene expression SOCS3 Gene Information Basic Information Ensembl ID: ENSG00000184557 Description: suppressor of cytokine signaling 3 [Source:HGNC Symbol;Acc:HGNC:19391] Location: 17:78356778-78360077 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell pericyte fibroblast stromal cell smooth muscle cell CD4+ T cell granulocyte epithelial cell monocyte basal cell developing T cell Other: Cytokine Signaling in Immune system Adaptive Immune System Signaling by Leptin SOX2 Gene Information Basic Information Ensembl ID: ENSG00000181449 Description: SRY-box transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:11195] Location: 3:181711925-181714436 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell pericyte progenitor cell embryonic cell fibroblast glial cell neural crest cell stem cell cancer stem cell ectodermal cell basal cell Other: Cytokine Signaling in Immune system Signaling by WNT Transcriptional regulation of pluripotent stem cells STAT1 Gene Information Basic Information Ensembl ID: ENSG00000115415 Description: signal transducer and activator of transcription 1 [Source:HGNC Symbol;Acc:HGNC:11362] Location: 2:190908460-191020960 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell Regulatory T cell CD8+ T cell leukocyte secretory cell monocyte epithelial cell Other: Cytokine Signaling in Immune system Signaling by NOTCH RNA Polymerase II Transcription STAT3 Gene Information Basic Information Ensembl ID: ENSG00000168610 Description: signal transducer and activator of transcription 3 [Source:HGNC Symbol;Acc:HGNC:11364] Location: 17:42313324-42388568 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: cancer cell Other: Apoptosis Cytokine Signaling in Immune system Cellular responses to stress STAT4 Gene Information Basic Information Ensembl ID: ENSG00000138378 Description: signal transducer and activator of transcription 4 [Source:HGNC Symbol;Acc:HGNC:11365] Location: 2:191029576-191178435 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell CD8+ T cell developing T cell T cell CD4+ T cell Specialized T cell lymphoid progenitor cell innate lymphoid cell lymphocyte Other: Cytokine Signaling in Immune system STAT5A Gene Information Basic Information Ensembl ID: ENSG00000126561 Description: signal transducer and activator of transcription 5A [Source:HGNC Symbol;Acc:HGNC:11366] Location: 17:42287547-42311943 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell CD4+ T cell adipocyte Other: Cytokine Signaling in Immune system Signaling by Leptin Signaling by Erythropoietin STAT5B Gene Information Basic Information Ensembl ID: ENSG00000173757 Description: signal transducer and activator of transcription 5B [Source:HGNC Symbol;Acc:HGNC:11367] Location: 17:42199176-42288633 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: trophoblast cell CD4+ T cell Other: Cytokine Signaling in Immune system Signaling by Leptin Signaling by Erythropoietin STAT6 Gene Information Basic Information Ensembl ID: ENSG00000166888 Description: signal transducer and activator of transcription 6 [Source:HGNC Symbol;Acc:HGNC:11368] Location: 12:57095408-57132139 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: secretory cell Other: Cytokine Signaling in Immune system Innate Immune System Signaling by Receptor Tyrosine Kinases SYK Gene Information Basic Information Ensembl ID: ENSG00000165025 Description: spleen associated tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:11491] Location: 9:90801787-90898549 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell phagocyte microglia Follicular B cell myeloid cell antigen presenting cell hematopoietic cell dendritic cell macrophage Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System TBK1 Gene Information Basic Information Ensembl ID: ENSG00000183735 Description: TANK binding kinase 1 [Source:HGNC Symbol;Acc:HGNC:11584] Location: 12:64452090-64502114 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell Other: Cytokine Signaling in Immune system Macroautophagy Innate Immune System TGFB1 Gene Information Basic Information Ensembl ID: ENSG00000105329 Description: transforming growth factor beta 1 [Source:HGNC Symbol;Acc:HGNC:11766] Location: 19:41301587-41353922 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell developing T cell T cell CD8+ T cell platelet Specialized T cell megakaryocyte Other: Platelet activation, signaling and aggregation RNA Polymerase II Transcription Cytokine Signaling in Immune system TNF Gene Information Basic Information Ensembl ID: ENSG00000232810 Description: tumor necrosis factor [Source:HGNC Symbol;Acc:HGNC:11892] Location: 6:31575565-31578336 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: macrophage CD4+ T cell Specialized T cell neuron T cell dendritic cell Other: Cytokine Signaling in Immune system Death Receptor Signaling Adipogenesis TNFRSF11A Gene Information Basic Information Ensembl ID: ENSG00000141655 Description: TNF receptor superfamily member 11a [Source:HGNC Symbol;Acc:HGNC:11908] Location: 18:62325287-62391288 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell Other: Cytokine Signaling in Immune system TNFRSF11B Gene Information Basic Information Ensembl ID: ENSG00000164761 Description: TNF receptor superfamily member 11b [Source:HGNC Symbol;Acc:HGNC:11909] Location: 8:118923557-118951885 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stromal cell epithelial cell Other: Cytokine Signaling in Immune system TNFRSF13C Gene Information Basic Information Ensembl ID: ENSG00000159958 Description: TNF receptor superfamily member 13C [Source:HGNC Symbol;Acc:HGNC:17755] Location: 22:41922032-41926806 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell Follicular B cell memory B cell Other: Cytokine Signaling in Immune system TNFRSF14 Gene Information Basic Information Ensembl ID: ENSG00000157873 Description: TNF receptor superfamily member 14 [Source:HGNC Symbol;Acc:HGNC:11912] Location: 1:2555639-2565382 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: CD8+ T cell Regulatory T cell Other: Cytokine Signaling in Immune system Adaptive Immune System TNFRSF17 Gene Information Basic Information Ensembl ID: ENSG00000048462 Description: TNF receptor superfamily member 17 [Source:HGNC Symbol;Acc:HGNC:11913] Location: 16:11965210-11968068 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell plasma cell plasmablast Other: Cytokine Signaling in Immune system TNFRSF18 Gene Information Basic Information Ensembl ID: ENSG00000186891 Description: TNF receptor superfamily member 18 [Source:HGNC Symbol;Acc:HGNC:11914] Location: 1:1203508-1206592 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell dendritic cell Regulatory T cell Specialized T cell innate lymphoid cell Naive B cell developing T cell Other: Cytokine Signaling in Immune system RNA Polymerase II Transcription TNFRSF1A Gene Information Basic Information Ensembl ID: ENSG00000067182 Description: TNF receptor superfamily member 1A [Source:HGNC Symbol;Acc:HGNC:11916] Location: 12:6328757-6342114 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell Other: Cytokine Signaling in Immune system Death Receptor Signaling TNFRSF1B Gene Information Basic Information Ensembl ID: ENSG00000028137 Description: TNF receptor superfamily member 1B [Source:HGNC Symbol;Acc:HGNC:11917] Location: 1:12166991-12209228 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell natural killer cell macrophage Regulatory T cell phagocyte microglia leukocyte monocyte granulocyte T cell dendritic cell Other: Cytokine Signaling in Immune system Innate Immune System TNFRSF25 Gene Information Basic Information Ensembl ID: ENSG00000215788 Description: TNF receptor superfamily member 25 [Source:HGNC Symbol;Acc:HGNC:11910] Location: 1:6460786-6466175 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: developing T cell Regulatory T cell CD4+ T cell memory T cell innate lymphoid cell Other: Cytokine Signaling in Immune system TNFRSF4 Gene Information Basic Information Ensembl ID: ENSG00000186827 Description: TNF receptor superfamily member 4 [Source:HGNC Symbol;Acc:HGNC:11918] Location: 1:1211326-1214153 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell macrophage Regulatory T cell T cell CD8+ T cell Other: Cytokine Signaling in Immune system TNFRSF8 Gene Information Basic Information Ensembl ID: ENSG00000120949 Description: TNF receptor superfamily member 8 [Source:HGNC Symbol;Acc:HGNC:11923] Location: 1:12063303-12144207 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: CD4+ T cell rheumatoid synovial cell Other: Cytokine Signaling in Immune system TNFRSF9 Gene Information Basic Information Ensembl ID: ENSG00000049249 Description: TNF receptor superfamily member 9 [Source:HGNC Symbol;Acc:HGNC:11924] Location: 1:7915871-7943165 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: developing T cell Regulatory T cell CD8+ T cell Specialized T cell T cell Other: Cytokine Signaling in Immune system TNFSF11 Gene Information Basic Information Ensembl ID: ENSG00000120659 Description: TNF superfamily member 11 [Source:HGNC Symbol;Acc:HGNC:11926] Location: 13:42562736-42608013 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stem cell Other: Cytokine Signaling in Immune system MITF-M-regulated melanocyte development TNFSF12 Gene Information Basic Information Ensembl ID: ENSG00000239697 Description: TNF superfamily member 12 [Source:HGNC Symbol;Acc:HGNC:11927] Location: 17:7548508-7557890 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system TNFSF13 Gene Information Basic Information Ensembl ID: ENSG00000161955 Description: TNF superfamily member 13 [Source:HGNC Symbol;Acc:HGNC:11928] Location: 17:7558292-7561608 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell monocyte Other: Cytokine Signaling in Immune system Regulation of mRNA stability by proteins that bind AU-rich elements TNFSF13B Gene Information Basic Information Ensembl ID: ENSG00000102524 Description: TNF superfamily member 13b [Source:HGNC Symbol;Acc:HGNC:11929] Location: 13:108251240-108308484 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell stromal cell macrophage phagocyte bone cell monocyte dendritic cell Other: Cytokine Signaling in Immune system TNFSF18 Gene Information Basic Information Ensembl ID: ENSG00000120337 Description: TNF superfamily member 18 [Source:HGNC Symbol;Acc:HGNC:11932] Location: 1:173039202-173050941 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system TNFSF4 Gene Information Basic Information Ensembl ID: ENSG00000117586 Description: TNF superfamily member 4 [Source:HGNC Symbol;Acc:HGNC:11934] Location: 1:173162645-173477583 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system TNFSF8 Gene Information Basic Information Ensembl ID: ENSG00000106952 Description: TNF superfamily member 8 [Source:HGNC Symbol;Acc:HGNC:11938] Location: 9:114893343-114930595 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Regulatory T cell T cell CD4+ T cell developing T cell Other: Cytokine Signaling in Immune system TNFSF9 Gene Information Basic Information Ensembl ID: ENSG00000125657 Description: TNF superfamily member 9 [Source:HGNC Symbol;Acc:HGNC:11939] Location: 19:6531026-6535924 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: T cell endothelial cell Other: Cytokine Signaling in Immune system TP53 Gene Information Basic Information Ensembl ID: ENSG00000141510 Description: tumor protein p53 [Source:HGNC Symbol;Acc:HGNC:11998] Location: 17:7661779-7687546 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Cytokine Signaling in Immune system Signaling by NOTCH TRAF2 Gene Information Basic Information Ensembl ID: ENSG00000127191 Description: TNF receptor associated factor 2 [Source:HGNC Symbol;Acc:HGNC:12032] Location: 9:136881912-136929221 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System TSLP Gene Information Basic Information Ensembl ID: ENSG00000145777 Description: thymic stromal lymphopoietin [Source:HGNC Symbol;Acc:HGNC:30743] Location: 5:111070062-111078026 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system TWIST1 Gene Information Basic Information Ensembl ID: ENSG00000122691 Description: twist family bHLH transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:12428] Location: 7:19020991-19117636 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte embryonic cell fibroblast stromal cell epithelial cell mesenchymal cell Other: Cytokine Signaling in Immune system Cell junction organization RNA Polymerase II Transcription TYK2 Gene Information Basic Information Ensembl ID: ENSG00000105397 Description: tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:12440] Location: 19:10350528-10380608 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades Signaling by ALK in cancer VCAM1 Gene Information Basic Information Ensembl ID: ENSG00000162692 Description: vascular cell adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:12663] Location: 1:100719742-100739045 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell stromal cell monocyte stem cell fibroblast Specialized T cell epithelial cell dendritic cell macrophage adipocyte mesenchymal stem cell cardiomyocyte Other: Cytokine Signaling in Immune system Adaptive Immune System Integrin cell surface interactions VEGFA Gene Information Basic Information Ensembl ID: ENSG00000112715 Description: vascular endothelial growth factor A [Source:HGNC Symbol;Acc:HGNC:12680] Location: 6:43770184-43786487 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell macrophage epithelial cell stem cell monocyte fibroblast microglia pancreatic cell granulocyte secretory cell astrocyte dendritic cell endothelial cell Other: Cytokine Signaling in Immune system Cellular responses to stress RNA Polymerase II Transcription VIM Gene Information Basic Information Ensembl ID: ENSG00000026025 Description: vimentin [Source:HGNC Symbol;Acc:HGNC:12692] Location: 10:17228241-17237593 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell pericyte macrophage monocyte stem cell embryonic cell phagocyte fibroblast glial cell smooth muscle cell oligodendrocyte precursor cell bone cell mast cell granulocyte antigen presenting cell interstitial cell mesenchymal cell mesenchymal stem cell Other: Apoptosis Cytokine Signaling in Immune system Macroautophagy
DNA Double-Strand Break Repair Pathway Hierarchies & Genes Nonhomologous End-Joining (NHEJ) (3 genes) DNA Repair DNA Double-Strand Break Repair Homology Directed Repair HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-Loop Structures Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 1 genes DNA Double Strand Break Response Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) 2 genes Presynaptic phase of homologous DNA pairing and strand exchange (2 genes) DNA Repair DNA Double-Strand Break Repair Homology Directed Repair HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange 2 genes Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (1 genes) DNA Repair DNA Double-Strand Break Repair Homology Directed Repair HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) HDR through Single Strand Annealing (SSA) DNA Double Strand Break Response Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 1 genes Processing of DNA double-strand break ends (1 genes) DNA Repair DNA Double-Strand Break Repair Homology Directed Repair HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) Processing of DNA double-strand break ends 1 genes Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (3 genes) DNA Repair DNA Double-Strand Break Repair DNA Double Strand Break Response Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 3 genes	ABL1 Gene Information Basic Information Ensembl ID: ENSG00000097007 Description: ABL proto-oncogene 1%2C non-receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:76] Location: 9:130713043-130887675 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Innate Immune System Epigenetic regulation of gene expression Myogenesis ATM Gene Information Basic Information Ensembl ID: ENSG00000149311 Description: ATM serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:795] Location: 11:108222804-108369102 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell T cell phagocyte hematopoietic cell Specialized T cell developing T cell Naive B cell lymphocyte Other: Meiosis Macroautophagy Cellular responses to stress ATR Gene Information Basic Information Ensembl ID: ENSG00000175054 Description: ATR serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:882] Location: 3:142449007-142578733 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Meiosis Cellular responses to stress DNA Double-Strand Break Repair BRCA1 Gene Information Basic Information Ensembl ID: ENSG00000012048 Description: BRCA1 DNA repair associated [Source:HGNC Symbol;Acc:HGNC:1100] Location: 17:43044295-43170245 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: cancer cell Other: Meiosis Cellular responses to stress DNA Double-Strand Break Repair CDK2 Gene Information Basic Information Ensembl ID: ENSG00000123374 Description: cyclin dependent kinase 2 [Source:HGNC Symbol;Acc:HGNC:1771] Location: 12:55966781-55972789 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Meiosis Cellular responses to stress DNA Double-Strand Break Repair CHEK1 Gene Information Basic Information Ensembl ID: ENSG00000149554 Description: checkpoint kinase 1 [Source:HGNC Symbol;Acc:HGNC:1925] Location: 11:125625163-125676255 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: DNA Double-Strand Break Repair Cell Cycle Checkpoints RNA Polymerase II Transcription CHEK2 Gene Information Basic Information Ensembl ID: ENSG00000183765 Description: checkpoint kinase 2 [Source:HGNC Symbol;Acc:HGNC:16627] Location: 22:28687743-28742422 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: DNA Double-Strand Break Repair Cell Cycle Checkpoints RNA Polymerase II Transcription MAPK8 Gene Information Basic Information Ensembl ID: ENSG00000107643 Description: mitogen-activated protein kinase 8 [Source:HGNC Symbol;Acc:HGNC:6881] Location: 10:48306639-48439360 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System RAD51 Gene Information Basic Information Ensembl ID: ENSG00000051180 Description: RAD51 recombinase [Source:HGNC Symbol;Acc:HGNC:9817] Location: 15:40694774-40732340 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Meiosis DNA Double-Strand Break Repair RNA Polymerase II Transcription TP53 Gene Information Basic Information Ensembl ID: ENSG00000141510 Description: tumor protein p53 [Source:HGNC Symbol;Acc:HGNC:11998] Location: 17:7661779-7687546 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Cytokine Signaling in Immune system Signaling by NOTCH
DNA Replication Pre-Initiation Pathway Hierarchies & Genes Activation of the pre-replicative complex (1 genes) DNA Replication DNA Replication Pre-Initiation Assembly of the pre-replicative complex Activation of the pre-replicative complex 1 genes Activation of the pre-replicative complex (1 genes) DNA Replication DNA Replication Pre-Initiation Activation of the pre-replicative complex 1 genes	CDK2 Gene Information Basic Information Ensembl ID: ENSG00000123374 Description: cyclin dependent kinase 2 [Source:HGNC Symbol;Acc:HGNC:1771] Location: 12:55966781-55972789 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Meiosis Cellular responses to stress DNA Double-Strand Break Repair MCM2 Gene Information Basic Information Ensembl ID: ENSG00000073111 Description: minichromosome maintenance complex component 2 [Source:HGNC Symbol;Acc:HGNC:6944] Location: 3:127598223-127622436 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: DNA Replication Pre-Initiation Synthesis of DNA Cell Cycle, Mitotic
Death Receptor Signaling Pathway Hierarchies & Genes Regulation of TNFR1 signaling (3 genes) Signal Transduction Death Receptor Signaling p75 NTR receptor-mediated signalling p75NTR signals via NF-kB p75NTR recruits signalling complexes 2 genes TNF signaling Regulation of TNFR1 signaling 1 genes TRAIL signaling (7 genes) Signal Transduction Death Receptor Signaling TNF signaling TNFR1-induced proapoptotic signaling 5 genes FasL/ CD95L signaling TRAIL signaling 2 genes Axonal growth inhibition (RHOA activation) (1 genes) Signal Transduction Death Receptor Signaling p75 NTR receptor-mediated signalling p75NTR regulates axonogenesis Axonal growth inhibition (RHOA activation) 1 genes NADE modulates death signalling (1 genes) Signal Transduction Death Receptor Signaling p75 NTR receptor-mediated signalling Cell death signalling via NRAGE, NRIF and NADE NADE modulates death signalling 1 genes NF-kB is activated and signals survival (2 genes) Signal Transduction Death Receptor Signaling p75 NTR receptor-mediated signalling p75NTR signals via NF-kB NF-kB is activated and signals survival 2 genes NRAGE signals death through JNK (1 genes) Signal Transduction Death Receptor Signaling p75 NTR receptor-mediated signalling Cell death signalling via NRAGE, NRIF and NADE NRAGE signals death through JNK 1 genes Regulation of TNFR1 signaling (1 genes) Signal Transduction Death Receptor Signaling TNF signaling Regulation of TNFR1 signaling 1 genes TRAIL signaling (3 genes) Signal Transduction Death Receptor Signaling FasL/ CD95L signaling 2 genes TRAIL signaling 1 genes p75NTR negatively regulates cell cycle via SC1 (1 genes) Signal Transduction Death Receptor Signaling p75 NTR receptor-mediated signalling p75NTR negatively regulates cell cycle via SC1 1 genes TRAIL signaling (4 genes) Signal Transduction Death Receptor Signaling TRAIL signaling 4 genes	CASP10 Gene Information Basic Information Ensembl ID: ENSG00000003400 Description: caspase 10 [Source:HGNC Symbol;Acc:HGNC:1500] Location: 2:201182872-201229428 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: plasma cell Other: Death Receptor Signaling Innate Immune System RNA Polymerase II Transcription CASP3 Gene Information Basic Information Ensembl ID: ENSG00000164305 Description: caspase 3 [Source:HGNC Symbol;Acc:HGNC:1504] Location: 4:184627696-184650062 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron mast cell innate lymphoid cell progenitor cell stem cell basal cell Other: Apoptosis Cytokine Signaling in Immune system Degradation of the extracellular matrix CASP8 Gene Information Basic Information Ensembl ID: ENSG00000064012 Description: caspase 8 [Source:HGNC Symbol;Acc:HGNC:1509] Location: 2:201233443-201361836 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System CHUK Gene Information Basic Information Ensembl ID: ENSG00000213341 Description: component of inhibitor of nuclear factor kappa B kinase complex [Source:HGNC Symbol;Acc:HGNC:1974] Location: 10:100188300-100229596 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Intracellular signaling by second messengers Cytokine Signaling in Immune system Adaptive Immune System CYLD Gene Information Basic Information Ensembl ID: ENSG00000083799 Description: CYLD lysine 63 deubiquitinase [Source:HGNC Symbol;Acc:HGNC:2584] Location: 16:50742050-50801935 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell developing T cell Specialized T cell Regulatory T cell Other: Innate Immune System Post-translational protein modification Death Receptor Signaling FADD Gene Information Basic Information Ensembl ID: ENSG00000168040 Description: Fas associated via death domain [Source:HGNC Symbol;Acc:HGNC:3573] Location: 11:70203296-70207390 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Innate Immune System Regulated Necrosis FAS Gene Information Basic Information Ensembl ID: ENSG00000026103 Description: Fas cell surface death receptor [Source:HGNC Symbol;Acc:HGNC:11920] Location: 10:88953813-89029605 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: CD4+ T cell Regulatory T cell Other: Apoptosis Regulated Necrosis RNA Polymerase II Transcription FASLG Gene Information Basic Information Ensembl ID: ENSG00000117560 Description: Fas ligand [Source:HGNC Symbol;Acc:HGNC:11936] Location: 1:172659103-172666876 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell T cell Specialized T cell CD8+ T cell Other: Apoptosis Cytokine Signaling in Immune system Regulated Necrosis HDAC3 Gene Information Basic Information Ensembl ID: ENSG00000171720 Description: histone deacetylase 3 [Source:HGNC Symbol;Acc:HGNC:4854] Location: 5:141620876-141636849 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Death Receptor Signaling Signaling by NOTCH Mitochondrial biogenesis IKBKB Gene Information Basic Information Ensembl ID: ENSG00000104365 Description: inhibitor of nuclear factor kappa B kinase subunit beta [Source:HGNC Symbol;Acc:HGNC:5960] Location: 8:42271302-42332460 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell secretory cell T cell Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System IRAK1 Gene Information Basic Information Ensembl ID: ENSG00000184216 Description: interleukin 1 receptor associated kinase 1 [Source:HGNC Symbol;Acc:HGNC:6112] Location: X:154010506-154019902 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: monocyte Other: Cytokine Signaling in Immune system Innate Immune System RNA Polymerase II Transcription MAPK8 Gene Information Basic Information Ensembl ID: ENSG00000107643 Description: mitogen-activated protein kinase 8 [Source:HGNC Symbol;Acc:HGNC:6881] Location: 10:48306639-48439360 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System MYD88 Gene Information Basic Information Ensembl ID: ENSG00000172936 Description: MYD88 innate immune signal transduction adaptor [Source:HGNC Symbol;Acc:HGNC:7562] Location: 3:38138552-38143024 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: monocyte Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System NFKB1 Gene Information Basic Information Ensembl ID: ENSG00000109320 Description: nuclear factor kappa B subunit 1 [Source:HGNC Symbol;Acc:HGNC:7794] Location: 4:102501330-102617302 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System NGFR Gene Information Basic Information Ensembl ID: ENSG00000064300 Description: nerve growth factor receptor [Source:HGNC Symbol;Acc:HGNC:7809] Location: 17:49495293-49515008 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron interneuron glial cell smooth muscle cell schwann cell astrocyte stem cell stromal cell modulatory neuron neural stem cell mesenchymal stem cell Other: Death Receptor Signaling RELA Gene Information Basic Information Ensembl ID: ENSG00000173039 Description: RELA proto-oncogene%2C NF-kB subunit [Source:HGNC Symbol;Acc:HGNC:9955] Location: 11:65653599-65663090 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System TBK1 Gene Information Basic Information Ensembl ID: ENSG00000183735 Description: TANK binding kinase 1 [Source:HGNC Symbol;Acc:HGNC:11584] Location: 12:64452090-64502114 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell Other: Cytokine Signaling in Immune system Macroautophagy Innate Immune System TNF Gene Information Basic Information Ensembl ID: ENSG00000232810 Description: tumor necrosis factor [Source:HGNC Symbol;Acc:HGNC:11892] Location: 6:31575565-31578336 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: macrophage CD4+ T cell Specialized T cell neuron T cell dendritic cell Other: Cytokine Signaling in Immune system Death Receptor Signaling Adipogenesis TNFRSF10A Gene Information Basic Information Ensembl ID: ENSG00000104689 Description: TNF receptor superfamily member 10a [Source:HGNC Symbol;Acc:HGNC:11904] Location: 8:23190452-23225102 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Follicular B cell Other: Apoptosis Cell surface interactions at the vascular wall Regulated Necrosis TNFRSF10B Gene Information Basic Information Ensembl ID: ENSG00000120889 Description: TNF receptor superfamily member 10b [Source:HGNC Symbol;Acc:HGNC:11905] Location: 8:23020133-23069031 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Cell surface interactions at the vascular wall Regulated Necrosis TNFRSF10D Gene Information Basic Information Ensembl ID: ENSG00000173530 Description: TNF receptor superfamily member 10d [Source:HGNC Symbol;Acc:HGNC:11907] Location: 8:23135588-23164027 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell dendritic cell Other: Cell surface interactions at the vascular wall RNA Polymerase II Transcription Death Receptor Signaling TNFRSF1A Gene Information Basic Information Ensembl ID: ENSG00000067182 Description: TNF receptor superfamily member 1A [Source:HGNC Symbol;Acc:HGNC:11916] Location: 12:6328757-6342114 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell Other: Cytokine Signaling in Immune system Death Receptor Signaling TNFSF10 Gene Information Basic Information Ensembl ID: ENSG00000121858 Description: TNF superfamily member 10 [Source:HGNC Symbol;Acc:HGNC:11925] Location: 3:172505508-172523475 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell epithelial cell monocyte mast cell secretory cell Other: Apoptosis Regulated Necrosis Death Receptor Signaling TRAF2 Gene Information Basic Information Ensembl ID: ENSG00000127191 Description: TNF receptor associated factor 2 [Source:HGNC Symbol;Acc:HGNC:12032] Location: 9:136881912-136929221 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System
Degradation of the extracellular matrix Pathway Hierarchies & Genes Activation of Matrix Metalloproteinases (9 genes) Extracellular matrix organization Degradation of the extracellular matrix 5 genes Collagen degradation 2 genes Activation of Matrix Metalloproteinases 2 genes	CASP3 Gene Information Basic Information Ensembl ID: ENSG00000164305 Description: caspase 3 [Source:HGNC Symbol;Acc:HGNC:1504] Location: 4:184627696-184650062 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron mast cell innate lymphoid cell progenitor cell stem cell basal cell Other: Apoptosis Cytokine Signaling in Immune system Degradation of the extracellular matrix CDH1 Gene Information Basic Information Ensembl ID: ENSG00000039068 Description: cadherin 1 [Source:HGNC Symbol;Acc:HGNC:1748] Location: 16:68737292-68835537 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: goblet cell epithelial cell pneumocyte stem cell secretory cell tuft cell paneth cell ciliated cell neuroendocrine cell brush cell basal cell serous cell deuterosomal cell club Other: Apoptosis Adaptive Immune System Degradation of the extracellular matrix COL11A1 Gene Information Basic Information Ensembl ID: ENSG00000060718 Description: collagen type XI alpha 1 chain [Source:HGNC Symbol;Acc:HGNC:2186] Location: 1:102876467-103108872 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte fibroblast stromal cell oligodendrocyte precursor cell melanocyte oligodendrocyte Other: Degradation of the extracellular matrix Collagen formation Non-integrin membrane-ECM interactions COL5A1 Gene Information Basic Information Ensembl ID: ENSG00000130635 Description: collagen type V alpha 1 chain [Source:HGNC Symbol;Acc:HGNC:2209] Location: 9:134641803-134844843 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron pericyte stromal cell stellate cell fibroblast stem cell embryonic cell mesenchymal cell skeletal muscle cell Other: Degradation of the extracellular matrix Collagen formation Fibronectin matrix formation FN1 Gene Information Basic Information Ensembl ID: ENSG00000115414 Description: fibronectin 1 [Source:HGNC Symbol;Acc:HGNC:3778] Location: 2:215360440-215436073 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell fibroblast endocrine cell pericyte epithelial cell stellate cell stem cell phagocyte muscle cell stromal cell smooth muscle cell thymic epithelial cell skeletal muscle cell mesenchymal cell Other: Cytokine Signaling in Immune system Degradation of the extracellular matrix Elastic fibre formation LAMB3 Gene Information Basic Information Ensembl ID: ENSG00000196878 Description: laminin subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:6490] Location: 1:209614870-209652425 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell stem cell pancreatic cell goblet cell M cell Other: Degradation of the extracellular matrix Collagen formation Laminin interactions LAMC2 Gene Information Basic Information Ensembl ID: ENSG00000058085 Description: laminin subunit gamma 2 [Source:HGNC Symbol;Acc:HGNC:6493] Location: 1:183186238-183245127 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell pancreatic cell goblet cell M cell stem cell Other: Degradation of the extracellular matrix Collagen formation Laminin interactions MMP2 Gene Information Basic Information Ensembl ID: ENSG00000087245 Description: matrix metallopeptidase 2 [Source:HGNC Symbol;Acc:HGNC:7166] Location: 16:55389700-55506691 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: mesenchymal cell smooth muscle cell Other: Cytokine Signaling in Immune system Degradation of the extracellular matrix Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MMP9 Gene Information Basic Information Ensembl ID: ENSG00000100985 Description: matrix metallopeptidase 9 [Source:HGNC Symbol;Acc:HGNC:7176] Location: 20:46008908-46016561 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell macrophage phagocyte neutrophil monocyte osteoclast Other: Cytokine Signaling in Immune system Degradation of the extracellular matrix Collagen formation
Developmental Cell Lineages Pathway Hierarchies & Genes Developmental Lineage of Multipotent Pancreatic Progenitor Cells (7 genes) Developmental Biology Developmental Cell Lineages Developmental Cell Lineages of the Integumentary System Developmental Lineages of the Mammary Gland Developmental Lineage of Mammary Gland Myoepithelial Cells 6 genes Developmental Cell Lineages of the Exocrine Pancreas Developmental Lineage of Multipotent Pancreatic Progenitor Cells 1 genes Developmental Lineage of Mammary Stem Cells (1 genes) Developmental Biology Developmental Cell Lineages Developmental Cell Lineages of the Integumentary System Developmental Lineages of the Mammary Gland Developmental Lineage of Mammary Stem Cells 1 genes Developmental Lineage of Multipotent Pancreatic Progenitor Cells (1 genes) Developmental Biology Developmental Cell Lineages Developmental Cell Lineages of the Exocrine Pancreas Developmental Lineage of Multipotent Pancreatic Progenitor Cells 1 genes Developmental Lineage of Pancreatic Acinar Cells (1 genes) Developmental Biology Developmental Cell Lineages Developmental Cell Lineages of the Exocrine Pancreas Developmental Lineage of Pancreatic Acinar Cells 1 genes Developmental Lineage of Pancreatic Ductal Cells (7 genes) Developmental Biology Developmental Cell Lineages Developmental Cell Lineages of the Exocrine Pancreas Developmental Lineage of Pancreatic Ductal Cells 7 genes Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin (1 genes) Developmental Biology Developmental Cell Lineages Developmental Cell Lineages of the Integumentary System Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin 1 genes	CD74 Gene Information Basic Information Ensembl ID: ENSG00000019582 Description: CD74 molecule [Source:HGNC Symbol;Acc:HGNC:1697] Location: 5:150401637-150412969 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell dendritic cell macrophage monocyte phagocyte Follicular B cell glial cell microglia Other: Adaptive Immune System Cell surface interactions at the vascular wall Developmental Cell Lineages CDH1 Gene Information Basic Information Ensembl ID: ENSG00000039068 Description: cadherin 1 [Source:HGNC Symbol;Acc:HGNC:1748] Location: 16:68737292-68835537 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: goblet cell epithelial cell pneumocyte stem cell secretory cell tuft cell paneth cell ciliated cell neuroendocrine cell brush cell basal cell serous cell deuterosomal cell club Other: Apoptosis Adaptive Immune System Degradation of the extracellular matrix COL11A1 Gene Information Basic Information Ensembl ID: ENSG00000060718 Description: collagen type XI alpha 1 chain [Source:HGNC Symbol;Acc:HGNC:2186] Location: 1:102876467-103108872 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte fibroblast stromal cell oligodendrocyte precursor cell melanocyte oligodendrocyte Other: Degradation of the extracellular matrix Collagen formation Non-integrin membrane-ECM interactions COL5A1 Gene Information Basic Information Ensembl ID: ENSG00000130635 Description: collagen type V alpha 1 chain [Source:HGNC Symbol;Acc:HGNC:2209] Location: 9:134641803-134844843 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron pericyte stromal cell stellate cell fibroblast stem cell embryonic cell mesenchymal cell skeletal muscle cell Other: Degradation of the extracellular matrix Collagen formation Fibronectin matrix formation EGF Gene Information Basic Information Ensembl ID: ENSG00000138798 Description: epidermal growth factor [Source:HGNC Symbol;Acc:HGNC:3229] Location: 4:109912883-110013766 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: skeletal muscle cell epithelial cell glial cell Other: Signaling by NOTCH Membrane Trafficking Cellular responses to stress EGFR Gene Information Basic Information Ensembl ID: ENSG00000146648 Description: epidermal growth factor receptor [Source:HGNC Symbol;Acc:HGNC:3236] Location: 7:55019017-55211628 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell endothelial cell trophoblast cell hepatocyte stem cell adipocyte fibroblast muscle cell stromal cell mesenchymal stem cell skeletal muscle cell cancer cell Other: Signaling by NOTCH Membrane Trafficking Signaling by GPCR EPCAM Gene Information Basic Information Ensembl ID: ENSG00000119888 Description: epithelial cell adhesion molecule [Source:HGNC Symbol;Acc:HGNC:11529] Location: 2:47345158-47387601 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron endocrine cell epithelial cell tuft cell enterocyte fibroblast secretory cell keratinocyte hepatocyte cancer cell Other: Cell surface interactions at the vascular wall Developmental Cell Lineages Bacterial Infection Pathways FGF2 Gene Information Basic Information Ensembl ID: ENSG00000138685 Description: fibroblast growth factor 2 [Source:HGNC Symbol;Acc:HGNC:3676] Location: 4:122826682-122898236 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: fibroblast glial cell adipocyte Other: Non-integrin membrane-ECM interactions Cytokine Signaling in Immune system Transcriptional regulation of pluripotent stem cells FN1 Gene Information Basic Information Ensembl ID: ENSG00000115414 Description: fibronectin 1 [Source:HGNC Symbol;Acc:HGNC:3778] Location: 2:215360440-215436073 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell fibroblast endocrine cell pericyte epithelial cell stellate cell stem cell phagocyte muscle cell stromal cell smooth muscle cell thymic epithelial cell skeletal muscle cell mesenchymal cell Other: Cytokine Signaling in Immune system Degradation of the extracellular matrix Elastic fibre formation GATA3 Gene Information Basic Information Ensembl ID: ENSG00000107485 Description: GATA binding protein 3 [Source:HGNC Symbol;Acc:HGNC:4172] Location: 10:8045378-8075198 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell epithelial cell trophoblast cell developing T cell Regulatory T cell phagocyte natural killer cell CD4+ T cell lymphocyte innate lymphoid cell T helper cell neuron Other: Cytokine Signaling in Immune system Post-translational protein modification RNA Polymerase II Transcription ITGA6 Gene Information Basic Information Ensembl ID: ENSG00000091409 Description: integrin subunit alpha 6 [Source:HGNC Symbol;Acc:HGNC:6142] Location: 2:172234216-172506459 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell goblet cell kidney cell pericyte epithelial cell embryonic cell stem cell glial cell stromal cell Other: Collagen formation Cell surface interactions at the vascular wall Integrin cell surface interactions ITGB1 Gene Information Basic Information Ensembl ID: ENSG00000150093 Description: integrin subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:6153] Location: 10:32887273-33005792 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stellate cell pericyte trophoblast cell epithelial cell stromal cell stem cell endothelial cell smooth muscle cell fibroblast mesenchymal stem cell Other: Laminin interactions Cell surface interactions at the vascular wall Cytokine Signaling in Immune system ITGB4 Gene Information Basic Information Ensembl ID: ENSG00000132470 Description: integrin subunit beta 4 [Source:HGNC Symbol;Acc:HGNC:6158] Location: 17:75721328-75757818 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron epithelial cell schwann cell astrocyte dendritic cell M cell endothelial cell Other: Collagen formation Laminin interactions Non-integrin membrane-ECM interactions LAMB3 Gene Information Basic Information Ensembl ID: ENSG00000196878 Description: laminin subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:6490] Location: 1:209614870-209652425 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell stem cell pancreatic cell goblet cell M cell Other: Degradation of the extracellular matrix Collagen formation Laminin interactions LAMC2 Gene Information Basic Information Ensembl ID: ENSG00000058085 Description: laminin subunit gamma 2 [Source:HGNC Symbol;Acc:HGNC:6493] Location: 1:183186238-183245127 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell pancreatic cell goblet cell M cell stem cell Other: Degradation of the extracellular matrix Collagen formation Laminin interactions PROM1 Gene Information Basic Information Ensembl ID: ENSG00000007062 Description: prominin 1 [Source:HGNC Symbol;Acc:HGNC:9454] Location: 4:15963076-16084378 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell neuron hematopoietic cell endothelial cell cancer cell hematopoietic progenitor cell cancer stem cell stem cell neural stem cell hematopoietic stem cell mesenchymal stem cell progenitor cell dermal papilla cell Other: Developmental Cell Lineages SOX9 Gene Information Basic Information Ensembl ID: ENSG00000125398 Description: SRY-box transcription factor 9 [Source:HGNC Symbol;Acc:HGNC:11204] Location: 17:72121020-72126416 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stem cell glial cell stromal cell tuft cell fibroblast ionocyte epithelial cell M cell chondrocyte cancer stem cell progenitor cell ductal cell Other: Signaling by WNT RNA Polymerase II Transcription Transcriptional regulation of testis differentiation VIM Gene Information Basic Information Ensembl ID: ENSG00000026025 Description: vimentin [Source:HGNC Symbol;Acc:HGNC:12692] Location: 10:17228241-17237593 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell pericyte macrophage monocyte stem cell embryonic cell phagocyte fibroblast glial cell smooth muscle cell oligodendrocyte precursor cell bone cell mast cell granulocyte antigen presenting cell interstitial cell mesenchymal cell mesenchymal stem cell Other: Apoptosis Cytokine Signaling in Immune system Macroautophagy
Dissolution of Fibrin Clot Pathway Hierarchies & Genes Dissolution of Fibrin Clot (1 genes) Hemostasis Dissolution of Fibrin Clot 1 genes	PLAU Gene Information Basic Information Ensembl ID: ENSG00000122861 Description: plasminogen activator%2C urokinase [Source:HGNC Symbol;Acc:HGNC:9052] Location: 10:73909177-73917496 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell stem cell mast cell neutrophil goblet cell Other: Innate Immune System Dissolution of Fibrin Clot
ECM proteoglycans Pathway Hierarchies & Genes ECM proteoglycans (11 genes) Extracellular matrix organization ECM proteoglycans 11 genes	COL5A1 Gene Information Basic Information Ensembl ID: ENSG00000130635 Description: collagen type V alpha 1 chain [Source:HGNC Symbol;Acc:HGNC:2209] Location: 9:134641803-134844843 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron pericyte stromal cell stellate cell fibroblast stem cell embryonic cell mesenchymal cell skeletal muscle cell Other: Degradation of the extracellular matrix Collagen formation Fibronectin matrix formation FN1 Gene Information Basic Information Ensembl ID: ENSG00000115414 Description: fibronectin 1 [Source:HGNC Symbol;Acc:HGNC:3778] Location: 2:215360440-215436073 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell fibroblast endocrine cell pericyte epithelial cell stellate cell stem cell phagocyte muscle cell stromal cell smooth muscle cell thymic epithelial cell skeletal muscle cell mesenchymal cell Other: Cytokine Signaling in Immune system Degradation of the extracellular matrix Elastic fibre formation ITGA2 Gene Information Basic Information Ensembl ID: ENSG00000164171 Description: integrin subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:6137] Location: 5:52989340-53094779 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell stem cell pancreatic cell goblet cell Other: Integrin cell surface interactions Laminin interactions Non-integrin membrane-ECM interactions ITGAV Gene Information Basic Information Ensembl ID: ENSG00000138448 Description: integrin subunit alpha V [Source:HGNC Symbol;Acc:HGNC:6150] Location: 2:186590010-186680901 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell glial cell stromal cell M cell endothelial cell Other: Adaptive Immune System Elastic fibre formation Innate Immune System ITGAX Gene Information Basic Information Ensembl ID: ENSG00000140678 Description: integrin subunit alpha X [Source:HGNC Symbol;Acc:HGNC:6152] Location: 16:31355134-31382999 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell natural killer cell phagocyte mast cell monocyte granulocyte dendritic cell Other: Cytokine Signaling in Immune system Innate Immune System Cell surface interactions at the vascular wall ITGB1 Gene Information Basic Information Ensembl ID: ENSG00000150093 Description: integrin subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:6153] Location: 10:32887273-33005792 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stellate cell pericyte trophoblast cell epithelial cell stromal cell stem cell endothelial cell smooth muscle cell fibroblast mesenchymal stem cell Other: Laminin interactions Cell surface interactions at the vascular wall Cytokine Signaling in Immune system ITGB3 Gene Information Basic Information Ensembl ID: ENSG00000259207 Description: integrin subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:6156] Location: 17:47253827-47313743 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: platelet epithelial cell monocyte Other: ECM proteoglycans Elastic fibre formation Cell surface interactions at the vascular wall NCAM1 Gene Information Basic Information Ensembl ID: ENSG00000149294 Description: neural cell adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:7656] Location: 11:112961275-113278436 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron natural killer cell interneuron pericyte T cell glial cell smooth muscle cell motor neuron Specialized T cell innate lymphoid cell chromaffin cell epithelial cell neuroendocrine cell lymphocyte cancer stem cell progenitor cell stem cell mesenchymal stem cell immune cell cancer cell autonomic neuron Other: ECM proteoglycans Cytokine Signaling in Immune system MAPK family signaling cascades TGFB1 Gene Information Basic Information Ensembl ID: ENSG00000105329 Description: transforming growth factor beta 1 [Source:HGNC Symbol;Acc:HGNC:11766] Location: 19:41301587-41353922 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell developing T cell T cell CD8+ T cell platelet Specialized T cell megakaryocyte Other: Platelet activation, signaling and aggregation RNA Polymerase II Transcription Cytokine Signaling in Immune system TGFB2 Gene Information Basic Information Ensembl ID: ENSG00000092969 Description: transforming growth factor beta 2 [Source:HGNC Symbol;Acc:HGNC:11768] Location: 1:218345336-218444619 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell Other: Elastic fibre formation ECM proteoglycans Platelet activation, signaling and aggregation TGFB3 Gene Information Basic Information Ensembl ID: ENSG00000119699 Description: transforming growth factor beta 3 [Source:HGNC Symbol;Acc:HGNC:11769] Location: 14:75958097-75983011 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte fibroblast Other: Elastic fibre formation ECM proteoglycans Platelet activation, signaling and aggregation
Elastic fibre formation Pathway Hierarchies & Genes Molecules associated with elastic fibres (7 genes) Extracellular matrix organization Elastic fibre formation 1 genes Molecules associated with elastic fibres 6 genes Molecules associated with elastic fibres (4 genes) Extracellular matrix organization Elastic fibre formation Molecules associated with elastic fibres 4 genes	BMP2 Gene Information Basic Information Ensembl ID: ENSG00000125845 Description: bone morphogenetic protein 2 [Source:HGNC Symbol;Acc:HGNC:1069] Location: 20:6767686-6780246 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell osteoblast Other: Elastic fibre formation RNA Polymerase II Transcription Signaling by TGFB family members FN1 Gene Information Basic Information Ensembl ID: ENSG00000115414 Description: fibronectin 1 [Source:HGNC Symbol;Acc:HGNC:3778] Location: 2:215360440-215436073 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell fibroblast endocrine cell pericyte epithelial cell stellate cell stem cell phagocyte muscle cell stromal cell smooth muscle cell thymic epithelial cell skeletal muscle cell mesenchymal cell Other: Cytokine Signaling in Immune system Degradation of the extracellular matrix Elastic fibre formation ITGA5 Gene Information Basic Information Ensembl ID: ENSG00000161638 Description: integrin subunit alpha 5 [Source:HGNC Symbol;Acc:HGNC:6141] Location: 12:54395261-54419266 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell epithelial cell stromal cell smooth muscle cell trophoblast cell mesenchymal stem cell fibroblast Other: Elastic fibre formation Fibronectin matrix formation Cell surface interactions at the vascular wall ITGAV Gene Information Basic Information Ensembl ID: ENSG00000138448 Description: integrin subunit alpha V [Source:HGNC Symbol;Acc:HGNC:6150] Location: 2:186590010-186680901 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell glial cell stromal cell M cell endothelial cell Other: Adaptive Immune System Elastic fibre formation Innate Immune System ITGB1 Gene Information Basic Information Ensembl ID: ENSG00000150093 Description: integrin subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:6153] Location: 10:32887273-33005792 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stellate cell pericyte trophoblast cell epithelial cell stromal cell stem cell endothelial cell smooth muscle cell fibroblast mesenchymal stem cell Other: Laminin interactions Cell surface interactions at the vascular wall Cytokine Signaling in Immune system ITGB3 Gene Information Basic Information Ensembl ID: ENSG00000259207 Description: integrin subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:6156] Location: 17:47253827-47313743 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: platelet epithelial cell monocyte Other: ECM proteoglycans Elastic fibre formation Cell surface interactions at the vascular wall ITGB8 Gene Information Basic Information Ensembl ID: ENSG00000105855 Description: integrin subunit beta 8 [Source:HGNC Symbol;Acc:HGNC:6163] Location: 7:20330702-20415754 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell neuron pericyte embryonic cell trophoblast cell glial cell stromal cell schwann cell Other: Elastic fibre formation Integrin cell surface interactions Signaling by TGFB family members LTBP1 Gene Information Basic Information Ensembl ID: ENSG00000049323 Description: latent transforming growth factor beta binding protein 1 [Source:HGNC Symbol;Acc:HGNC:6714] Location: 2:32946953-33399509 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell endocrine cell pericyte epithelial cell fibroblast stromal cell smooth muscle cell cardiomyocyte muscle cell platelet interstitial cell progenitor cell dendritic cell glial cell erythroblast megakaryocyte Other: Elastic fibre formation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein modification TGFB1 Gene Information Basic Information Ensembl ID: ENSG00000105329 Description: transforming growth factor beta 1 [Source:HGNC Symbol;Acc:HGNC:11766] Location: 19:41301587-41353922 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell developing T cell T cell CD8+ T cell platelet Specialized T cell megakaryocyte Other: Platelet activation, signaling and aggregation RNA Polymerase II Transcription Cytokine Signaling in Immune system TGFB2 Gene Information Basic Information Ensembl ID: ENSG00000092969 Description: transforming growth factor beta 2 [Source:HGNC Symbol;Acc:HGNC:11768] Location: 1:218345336-218444619 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell Other: Elastic fibre formation ECM proteoglycans Platelet activation, signaling and aggregation TGFB3 Gene Information Basic Information Ensembl ID: ENSG00000119699 Description: transforming growth factor beta 3 [Source:HGNC Symbol;Acc:HGNC:11769] Location: 14:75958097-75983011 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte fibroblast Other: Elastic fibre formation ECM proteoglycans Platelet activation, signaling and aggregation
Epigenetic regulation of gene expression Pathway Hierarchies & Genes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis (6 genes) Gene expression (Transcription) Epigenetic regulation of gene expression Epigenetic regulation by WDR5-containing histone modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis 6 genes Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) (3 genes) Gene expression (Transcription) Epigenetic regulation of gene expression PRC2 methylates histones and DNA 1 genes DNA methylation Regulation of endogenous retroelements Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 2 genes Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) (1 genes) Gene expression (Transcription) Epigenetic regulation of gene expression Regulation of endogenous retroelements Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 1 genes	ABL1 Gene Information Basic Information Ensembl ID: ENSG00000097007 Description: ABL proto-oncogene 1%2C non-receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:76] Location: 9:130713043-130887675 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Innate Immune System Epigenetic regulation of gene expression Myogenesis CREBBP Gene Information Basic Information Ensembl ID: ENSG00000005339 Description: CREB binding protein [Source:HGNC Symbol;Acc:HGNC:2348] Location: 16:3725054-3880713 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes BMAL1:CLOCK,NPAS2 activates circadian expression DNMT1 Gene Information Basic Information Ensembl ID: ENSG00000130816 Description: DNA methyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:2976] Location: 19:10133342-10231286 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell lymphoid progenitor cell Follicular B cell Other: Epigenetic regulation of gene expression Post-translational protein modification Signaling by Receptor Tyrosine Kinases DNMT3A Gene Information Basic Information Ensembl ID: ENSG00000119772 Description: DNA methyltransferase 3 alpha [Source:HGNC Symbol;Acc:HGNC:2978] Location: 2:25227855-25342590 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Defective pyroptosis Epigenetic regulation of gene expression Chromatin modifying enzymes EZH2 Gene Information Basic Information Ensembl ID: ENSG00000106462 Description: enhancer of zeste 2 polycomb repressive complex 2 subunit [Source:HGNC Symbol;Acc:HGNC:3527] Location: 7:148807257-148884321 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell Other: Epigenetic regulation of gene expression Cellular responses to stress Chromatin modifying enzymes HDAC3 Gene Information Basic Information Ensembl ID: ENSG00000171720 Description: histone deacetylase 3 [Source:HGNC Symbol;Acc:HGNC:4854] Location: 5:141620876-141636849 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Death Receptor Signaling Signaling by NOTCH Mitochondrial biogenesis PPARG Gene Information Basic Information Ensembl ID: ENSG00000132170 Description: peroxisome proliferator activated receptor gamma [Source:HGNC Symbol;Acc:HGNC:9236] Location: 3:12287368-12434356 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell pericyte epithelial cell stem cell phagocyte adipocyte macrophage tuft cell Other: Epigenetic regulation of gene expression Metabolism of lipids Post-translational protein modification PPARGC1A Gene Information Basic Information Ensembl ID: ENSG00000109819 Description: PPARG coactivator 1 alpha [Source:HGNC Symbol;Acc:HGNC:9237] Location: 4:23755041-23904089 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Mitochondrial biogenesis Epigenetic regulation of gene expression Cellular responses to stress RB1 Gene Information Basic Information Ensembl ID: ENSG00000139687 Description: RB transcriptional corepressor 1 [Source:HGNC Symbol;Acc:HGNC:9884] Location: 13:48303744-48599436 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell endothelial cell microglia neuron Other: Epigenetic regulation of gene expression Cellular responses to stress Cell junction organization SMARCA4 Gene Information Basic Information Ensembl ID: ENSG00000127616 Description: SWI/SNF related%2C matrix associated%2C actin dependent regulator of chromatin%2C subfamily a%2C member 4 [Source:HGNC Symbol;Acc:HGNC:11100] Location: 19:10960932-11079426 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell epithelial cell fibroblast Other: Cytokine Signaling in Immune system Signaling by WNT Epigenetic regulation of gene expression
Expression of BMAL (ARNTL), CLOCK, and NPAS2 Pathway Hierarchies & Genes Expression of BMAL (ARNTL), CLOCK, and NPAS2 (4 genes) Circadian clock Expression of BMAL (ARNTL), CLOCK, and NPAS2 4 genes	CREBBP Gene Information Basic Information Ensembl ID: ENSG00000005339 Description: CREB binding protein [Source:HGNC Symbol;Acc:HGNC:2348] Location: 16:3725054-3880713 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes BMAL1:CLOCK,NPAS2 activates circadian expression HDAC3 Gene Information Basic Information Ensembl ID: ENSG00000171720 Description: histone deacetylase 3 [Source:HGNC Symbol;Acc:HGNC:4854] Location: 5:141620876-141636849 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Death Receptor Signaling Signaling by NOTCH Mitochondrial biogenesis PPARGC1A Gene Information Basic Information Ensembl ID: ENSG00000109819 Description: PPARG coactivator 1 alpha [Source:HGNC Symbol;Acc:HGNC:9237] Location: 4:23755041-23904089 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Mitochondrial biogenesis Epigenetic regulation of gene expression Cellular responses to stress RORC Gene Information Basic Information Ensembl ID: ENSG00000143365 Description: RAR related orphan receptor C [Source:HGNC Symbol;Acc:HGNC:10260] Location: 1:151806071-151831845 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: CD4+ T cell T cell innate lymphoid cell Specialized T cell Other: Cytokine Signaling in Immune system RNA Polymerase II Transcription Expression of BMAL (ARNTL), CLOCK, and NPAS2
Factors involved in megakaryocyte development and platelet production Pathway Hierarchies & Genes Factors involved in megakaryocyte development and platelet production (7 genes) Hemostasis Factors involved in megakaryocyte development and platelet production 7 genes	ABL1 Gene Information Basic Information Ensembl ID: ENSG00000097007 Description: ABL proto-oncogene 1%2C non-receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:76] Location: 9:130713043-130887675 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Innate Immune System Epigenetic regulation of gene expression Myogenesis CDK2 Gene Information Basic Information Ensembl ID: ENSG00000123374 Description: cyclin dependent kinase 2 [Source:HGNC Symbol;Acc:HGNC:1771] Location: 12:55966781-55972789 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Meiosis Cellular responses to stress DNA Double-Strand Break Repair GATA3 Gene Information Basic Information Ensembl ID: ENSG00000107485 Description: GATA binding protein 3 [Source:HGNC Symbol;Acc:HGNC:4172] Location: 10:8045378-8075198 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell epithelial cell trophoblast cell developing T cell Regulatory T cell phagocyte natural killer cell CD4+ T cell lymphocyte innate lymphoid cell T helper cell neuron Other: Cytokine Signaling in Immune system Post-translational protein modification RNA Polymerase II Transcription IFNB1 Gene Information Basic Information Ensembl ID: ENSG00000171855 Description: interferon beta 1 [Source:HGNC Symbol;Acc:HGNC:5434] Location: 9:21077104-21077942 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Innate Immune System Cellular responses to stress IRF2 Gene Information Basic Information Ensembl ID: ENSG00000168310 Description: interferon regulatory factor 2 [Source:HGNC Symbol;Acc:HGNC:6117] Location: 4:184385702-184474558 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Regulated Necrosis Factors involved in megakaryocyte development and platelet production JAK2 Gene Information Basic Information Ensembl ID: ENSG00000096968 Description: Janus kinase 2 [Source:HGNC Symbol;Acc:HGNC:6192] Location: 9:4984390-5129948 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: fibroblast basophil dendritic cell Other: Chromatin modifying enzymes Cytokine Signaling in Immune system Signaling by Leptin TP53 Gene Information Basic Information Ensembl ID: ENSG00000141510 Description: tumor protein p53 [Source:HGNC Symbol;Acc:HGNC:11998] Location: 17:7661779-7687546 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Cytokine Signaling in Immune system Signaling by NOTCH
Fanconi Anemia Pathway Pathway Hierarchies & Genes Fanconi Anemia Pathway (1 genes) DNA Repair Fanconi Anemia Pathway 1 genes	ATR Gene Information Basic Information Ensembl ID: ENSG00000175054 Description: ATR serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:882] Location: 3:142449007-142578733 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Meiosis Cellular responses to stress DNA Double-Strand Break Repair
Fibronectin matrix formation Pathway Hierarchies & Genes Fibronectin matrix formation (5 genes) Extracellular matrix organization Fibronectin matrix formation 5 genes	CEACAM1 Gene Information Basic Information Ensembl ID: ENSG00000079385 Description: CEA cell adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:1814] Location: 19:42507304-42561234 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell epithelial cell stem cell myeloid cell secretory cell neutrophil trophoblast cell Other: Fibronectin matrix formation Innate Immune System Cell surface interactions at the vascular wall COL5A1 Gene Information Basic Information Ensembl ID: ENSG00000130635 Description: collagen type V alpha 1 chain [Source:HGNC Symbol;Acc:HGNC:2209] Location: 9:134641803-134844843 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron pericyte stromal cell stellate cell fibroblast stem cell embryonic cell mesenchymal cell skeletal muscle cell Other: Degradation of the extracellular matrix Collagen formation Fibronectin matrix formation FN1 Gene Information Basic Information Ensembl ID: ENSG00000115414 Description: fibronectin 1 [Source:HGNC Symbol;Acc:HGNC:3778] Location: 2:215360440-215436073 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell fibroblast endocrine cell pericyte epithelial cell stellate cell stem cell phagocyte muscle cell stromal cell smooth muscle cell thymic epithelial cell skeletal muscle cell mesenchymal cell Other: Cytokine Signaling in Immune system Degradation of the extracellular matrix Elastic fibre formation ITGA5 Gene Information Basic Information Ensembl ID: ENSG00000161638 Description: integrin subunit alpha 5 [Source:HGNC Symbol;Acc:HGNC:6141] Location: 12:54395261-54419266 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell epithelial cell stromal cell smooth muscle cell trophoblast cell mesenchymal stem cell fibroblast Other: Elastic fibre formation Fibronectin matrix formation Cell surface interactions at the vascular wall ITGB1 Gene Information Basic Information Ensembl ID: ENSG00000150093 Description: integrin subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:6153] Location: 10:32887273-33005792 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stellate cell pericyte trophoblast cell epithelial cell stromal cell stem cell endothelial cell smooth muscle cell fibroblast mesenchymal stem cell Other: Laminin interactions Cell surface interactions at the vascular wall Cytokine Signaling in Immune system
Formation of Fibrin Clot (Clotting Cascade) Pathway Hierarchies & Genes Common Pathway of Fibrin Clot Formation (1 genes) Hemostasis Formation of Fibrin Clot (Clotting Cascade) Common Pathway of Fibrin Clot Formation 1 genes	THBD Gene Information Basic Information Ensembl ID: ENSG00000178726 Description: thrombomodulin [Source:HGNC Symbol;Acc:HGNC:11784] Location: 20:23045633-23049672 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell monocyte dendritic cell Other: Formation of Fibrin Clot (Clotting Cascade) Cell surface interactions at the vascular wall
Gastrulation Pathway Hierarchies & Genes Specification of the neural plate border (7 genes) Developmental Biology Gastrulation Germ layer formation at gastrulation Formation of paraxial mesoderm 1 genes Somitogenesis 3 genes Formation of axial mesoderm 2 genes Formation of definitive endoderm Specification of the neural plate border 1 genes Formation of definitive endoderm (2 genes) Developmental Biology Gastrulation Epithelial-Mesenchymal Transition (EMT) during gastrulation Formation of definitive endoderm 2 genes Somitogenesis (2 genes) Developmental Biology Gastrulation Formation of paraxial mesoderm Somitogenesis 2 genes Formation of intermediate mesoderm (1 genes) Developmental Biology Gastrulation Formation of intermediate mesoderm 1 genes Formation of paraxial mesoderm (1 genes) Developmental Biology Gastrulation Formation of paraxial mesoderm 1 genes	CDH1 Gene Information Basic Information Ensembl ID: ENSG00000039068 Description: cadherin 1 [Source:HGNC Symbol;Acc:HGNC:1748] Location: 16:68737292-68835537 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: goblet cell epithelial cell pneumocyte stem cell secretory cell tuft cell paneth cell ciliated cell neuroendocrine cell brush cell basal cell serous cell deuterosomal cell club Other: Apoptosis Adaptive Immune System Degradation of the extracellular matrix CREBBP Gene Information Basic Information Ensembl ID: ENSG00000005339 Description: CREB binding protein [Source:HGNC Symbol;Acc:HGNC:2348] Location: 16:3725054-3880713 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes BMAL1:CLOCK,NPAS2 activates circadian expression CTNNB1 Gene Information Basic Information Ensembl ID: ENSG00000168036 Description: catenin beta 1 [Source:HGNC Symbol;Acc:HGNC:2514] Location: 3:41194741-41260096 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell endothelial cell epithelial cell stem cell phagocyte adrenal cortical cell fibroblast monocyte Specialized T cell melanocyte M cell Other: Apoptosis Innate Immune System Signaling by WNT DLL3 Gene Information Basic Information Ensembl ID: ENSG00000090932 Description: delta like canonical Notch ligand 3 [Source:HGNC Symbol;Acc:HGNC:2909] Location: 19:39498895-39508481 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: sensory neuron glial cell schwann cell motor neuron Other: Gastrulation EOMES Gene Information Basic Information Ensembl ID: ENSG00000163508 Description: eomesodermin [Source:HGNC Symbol;Acc:HGNC:3372] Location: 3:27715949-27722711 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell Specialized T cell CD8+ T cell T cell progenitor cell mesodermal cell brush cell Other: Transcriptional regulation of pluripotent stem cells Cardiogenesis Gastrulation FGF2 Gene Information Basic Information Ensembl ID: ENSG00000138685 Description: fibroblast growth factor 2 [Source:HGNC Symbol;Acc:HGNC:3676] Location: 4:122826682-122898236 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: fibroblast glial cell adipocyte Other: Non-integrin membrane-ECM interactions Cytokine Signaling in Immune system Transcriptional regulation of pluripotent stem cells FGFR1 Gene Information Basic Information Ensembl ID: ENSG00000077782 Description: fibroblast growth factor receptor 1 [Source:HGNC Symbol;Acc:HGNC:3688] Location: 8:38400215-38468834 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell fibroblast epithelial cell stem cell stromal cell Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases LEF1 Gene Information Basic Information Ensembl ID: ENSG00000138795 Description: lymphoid enhancer binding factor 1 [Source:HGNC Symbol;Acc:HGNC:6551] Location: 4:108047545-108168956 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell developing T cell T cell Regulatory T cell Naive B cell CD4+ T cell lymphoid progenitor cell innate lymphoid cell Other: Signaling by WNT RNA Polymerase II Transcription Transcriptional regulation of granulopoiesis NOTCH1 Gene Information Basic Information Ensembl ID: ENSG00000148400 Description: notch receptor 1 [Source:HGNC Symbol;Acc:HGNC:7881] Location: 9:136494433-136546048 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte T cell stem cell cancer cell Other: Signaling by NOTCH Regulation of beta-cell development Cellular responses to stress SMAD2 Gene Information Basic Information Ensembl ID: ENSG00000175387 Description: SMAD family member 2 [Source:HGNC Symbol;Acc:HGNC:6768] Location: 18:47808957-47931146 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Signaling by NODAL Transcriptional regulation of pluripotent stem cells Post-translational protein modification SMAD3 Gene Information Basic Information Ensembl ID: ENSG00000166949 Description: SMAD family member 3 [Source:HGNC Symbol;Acc:HGNC:6769] Location: 15:67063763-67195173 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell stem cell mesenchymal cell Other: Signaling by NODAL Cytokine Signaling in Immune system Signaling by NOTCH SOX2 Gene Information Basic Information Ensembl ID: ENSG00000181449 Description: SRY-box transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:11195] Location: 3:181711925-181714436 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell pericyte progenitor cell embryonic cell fibroblast glial cell neural crest cell stem cell cancer stem cell ectodermal cell basal cell Other: Cytokine Signaling in Immune system Signaling by WNT Transcriptional regulation of pluripotent stem cells TCF7 Gene Information Basic Information Ensembl ID: ENSG00000081059 Description: transcription factor 7 [Source:HGNC Symbol;Acc:HGNC:11639] Location: 5:134114681-134151865 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell developing T cell T cell CD4+ T cell Specialized T cell innate lymphoid cell Other: Signaling by WNT RNA Polymerase II Transcription MITF-M-regulated melanocyte development
Innate Immune System Pathway Hierarchies & Genes Neutrophil degranulation (2 genes) Immune System Innate Immune System Cytosolic sensors of pathogen-associated DNA ZBP1(DAI) mediated induction of type I IFNs RIP-mediated NFkB activation via ZBP1 Toll-like Receptor Cascades 1 genes Toll Like Receptor 3 (TLR3) Cascade MAP kinase activation MAP3K8 (TPL2)-dependent MAPK1/3 activation Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Inflammasomes The NLRP3 inflammasome DDX58/IFIH1-mediated induction of interferon-alpha/beta TRAF6 mediated NF-kB activation Fc epsilon receptor (FCERI) signaling FCERI mediated NF-kB activation C-type lectin receptors (CLRs) CLEC7A (Dectin-1) signaling CLEC7A/inflammasome pathway Neutrophil degranulation 1 genes Dectin-1 mediated noncanonical NF-kB signaling (4 genes) Immune System Innate Immune System Cytosolic sensors of pathogen-associated DNA ZBP1(DAI) mediated induction of type I IFNs RIP-mediated NFkB activation via ZBP1 Toll-like Receptor Cascades Toll Like Receptor 4 (TLR4) Cascade MyD88-independent TLR4 cascade TRIF (TICAM1)-mediated TLR4 signaling 2 genes Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Inflammasomes The NLRP3 inflammasome DDX58/IFIH1-mediated induction of interferon-alpha/beta TRAF6 mediated NF-kB activation Fc epsilon receptor (FCERI) signaling FCERI mediated NF-kB activation C-type lectin receptors (CLRs) CLEC7A (Dectin-1) signaling Dectin-1 mediated noncanonical NF-kB signaling 2 genes CLEC7A (Dectin-1) signaling (1 genes) Immune System Innate Immune System Cytosolic sensors of pathogen-associated DNA ZBP1(DAI) mediated induction of type I IFNs RIP-mediated NFkB activation via ZBP1 Toll-like Receptor Cascades Toll Like Receptor 4 (TLR4) Cascade MyD88-independent TLR4 cascade TRIF (TICAM1)-mediated TLR4 signaling IKK complex recruitment mediated by RIP1 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway DDX58/IFIH1-mediated induction of interferon-alpha/beta TRAF6 mediated NF-kB activation Fc epsilon receptor (FCERI) signaling FCERI mediated NF-kB activation C-type lectin receptors (CLRs) CLEC7A (Dectin-1) signaling 1 genes Dectin-1 mediated noncanonical NF-kB signaling (4 genes) Immune System Innate Immune System Cytosolic sensors of pathogen-associated DNA ZBP1(DAI) mediated induction of type I IFNs RIP-mediated NFkB activation via ZBP1 Toll-like Receptor Cascades 1 genes Toll Like Receptor 4 (TLR4) Cascade MyD88-independent TLR4 cascade 2 genes TRIF (TICAM1)-mediated TLR4 signaling Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Inflammasomes The NLRP3 inflammasome DDX58/IFIH1-mediated induction of interferon-alpha/beta TRAF6 mediated NF-kB activation C-type lectin receptors (CLRs) CLEC7A (Dectin-1) signaling Dectin-1 mediated noncanonical NF-kB signaling 1 genes CLEC7A/inflammasome pathway (2 genes) Immune System Innate Immune System Toll-like Receptor Cascades Toll Like Receptor 4 (TLR4) Cascade MyD88-independent TLR4 cascade TRIF (TICAM1)-mediated TLR4 signaling TRIF-mediated programmed cell death Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway 1 genes DDX58/IFIH1-mediated induction of interferon-alpha/beta NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 C-type lectin receptors (CLRs) CLEC7A (Dectin-1) signaling CLEC7A/inflammasome pathway 1 genes Advanced glycosylation endproduct receptor signaling (4 genes) Immune System Innate Immune System Toll-like Receptor Cascades Toll Like Receptor 3 (TLR3) Cascade MAP kinase activation MAPK targets/ Nuclear events mediated by MAP kinases Activation of the AP-1 family of transcription factors Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation 1 genes Fc epsilon receptor (FCERI) signaling 1 genes FCERI mediated MAPK activation Neutrophil degranulation 1 genes Advanced glycosylation endproduct receptor signaling 1 genes TRAF3-dependent IRF activation pathway (2 genes) Immune System Innate Immune System Cytosolic sensors of pathogen-associated DNA ZBP1(DAI) mediated induction of type I IFNs IRF3 mediated activation of type 1 IFN Toll-like Receptor Cascades Toll Like Receptor 4 (TLR4) Cascade MyD88-independent TLR4 cascade TRIF (TICAM1)-mediated TLR4 signaling Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 DDX58/IFIH1-mediated induction of interferon-alpha/beta 1 genes TRAF3-dependent IRF activation pathway 1 genes FCERI mediated Ca+2 mobilization (2 genes) Immune System Innate Immune System Toll-like Receptor Cascades Toll Like Receptor 4 (TLR4) Cascade MyD88:MAL(TIRAP) cascade initiated on plasma membrane 1 genes Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation DAP12 interactions DAP12 signaling Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization 1 genes Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 (3 genes) Immune System Innate Immune System Cytosolic sensors of pathogen-associated DNA ZBP1(DAI) mediated induction of type I IFNs RIP-mediated NFkB activation via ZBP1 Toll-like Receptor Cascades Toll Like Receptor 4 (TLR4) Cascade MyD88-independent TLR4 cascade 1 genes TRIF (TICAM1)-mediated TLR4 signaling 1 genes Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 1 genes Dectin-2 family (4 genes) Immune System Innate Immune System Fcgamma receptor (FCGR) dependent phagocytosis FCGR activation DAP12 interactions 1 genes DAP12 signaling Fc epsilon receptor (FCERI) signaling Role of LAT2/NTAL/LAB on calcium mobilization 1 genes C-type lectin receptors (CLRs) Dectin-2 family 2 genes NOD1/2 Signaling Pathway (1 genes) Immune System Innate Immune System Toll-like Receptor Cascades Toll Like Receptor 4 (TLR4) Cascade MyD88-independent TLR4 cascade TRIF (TICAM1)-mediated TLR4 signaling TRAF6-mediated induction of TAK1 complex within TLR4 complex Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway 1 genes NOD1/2 Signaling Pathway (1 genes) Immune System Innate Immune System Toll-like Receptor Cascades Toll Like Receptor 9 (TLR9) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway 1 genes Neutrophil degranulation (6 genes) Immune System Innate Immune System DAP12 interactions DAP12 signaling 3 genes Fc epsilon receptor (FCERI) signaling FCERI mediated MAPK activation C-type lectin receptors (CLRs) CD209 (DC-SIGN) signaling 2 genes Neutrophil degranulation 1 genes Neutrophil degranulation (4 genes) Immune System Innate Immune System Antimicrobial peptides Defensins Beta defensins 2 genes Toll-like Receptor Cascades Toll Like Receptor 4 (TLR4) Cascade MyD88:MAL(TIRAP) cascade initiated on plasma membrane 1 genes Neutrophil degranulation 1 genes CD209 (DC-SIGN) signaling (4 genes) Immune System Innate Immune System DDX58/IFIH1-mediated induction of interferon-alpha/beta TRAF3-dependent IRF activation pathway 3 genes Cytosolic sensors of pathogen-associated DNA LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production C-type lectin receptors (CLRs) CD209 (DC-SIGN) signaling 1 genes FCERI mediated MAPK activation (1 genes) Immune System Innate Immune System Toll-like Receptor Cascades Toll Like Receptor 3 (TLR3) Cascade MAP kinase activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Fc epsilon receptor (FCERI) signaling FCERI mediated MAPK activation 1 genes Role of LAT2/NTAL/LAB on calcium mobilization (1 genes) Immune System Innate Immune System Fcgamma receptor (FCGR) dependent phagocytosis Role of phospholipids in phagocytosis DAP12 interactions DAP12 signaling Fc epsilon receptor (FCERI) signaling Role of LAT2/NTAL/LAB on calcium mobilization 1 genes Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (1 genes) Immune System Innate Immune System Toll-like Receptor Cascades Toll Like Receptor 4 (TLR4) Cascade MyD88-independent TLR4 cascade TRIF (TICAM1)-mediated TLR4 signaling Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 1 genes CLEC7A (Dectin-1) induces NFAT activation (2 genes) Immune System Innate Immune System Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization 1 genes C-type lectin receptors (CLRs) CLEC7A (Dectin-1) signaling CLEC7A (Dectin-1) induces NFAT activation 1 genes CLEC7A (Dectin-1) signaling (1 genes) Immune System Innate Immune System Fc epsilon receptor (FCERI) signaling FCERI mediated NF-kB activation C-type lectin receptors (CLRs) CLEC7A (Dectin-1) signaling 1 genes MAPK targets/ Nuclear events mediated by MAP kinases (2 genes) Immune System Innate Immune System Toll-like Receptor Cascades Toll Like Receptor 3 (TLR3) Cascade MAP kinase activation MAPK targets/ Nuclear events mediated by MAP kinases 2 genes Negative regulators of DDX58/IFIH1 signaling (1 genes) Immune System Innate Immune System Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway DDX58/IFIH1-mediated induction of interferon-alpha/beta Negative regulators of DDX58/IFIH1 signaling 1 genes Neutrophil degranulation (2 genes) Immune System Innate Immune System Cytosolic sensors of pathogen-associated DNA STING mediated induction of host immune responses STAT6-mediated induction of chemokines 1 genes Neutrophil degranulation 1 genes TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (3 genes) Immune System Innate Immune System Toll-like Receptor Cascades Toll Like Receptor 9 (TLR9) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 3 genes Alpha-defensins (1 genes) Immune System Innate Immune System Antimicrobial peptides Defensins Alpha-defensins 1 genes CLEC7A/inflammasome pathway (1 genes) Immune System Innate Immune System C-type lectin receptors (CLRs) CLEC7A (Dectin-1) signaling CLEC7A/inflammasome pathway 1 genes Dectin-1 mediated noncanonical NF-kB signaling (1 genes) Immune System Innate Immune System C-type lectin receptors (CLRs) CLEC7A (Dectin-1) signaling Dectin-1 mediated noncanonical NF-kB signaling 1 genes MyD88 cascade initiated on plasma membrane (1 genes) Immune System Innate Immune System Toll-like Receptor Cascades Toll Like Receptor 10 (TLR10) Cascade MyD88 cascade initiated on plasma membrane 1 genes Neutrophil degranulation (1 genes) Immune System Innate Immune System ROS and RNS production in phagocytes Events associated with phagocytolytic activity of PMN cells Neutrophil degranulation 1 genes Neutrophil degranulation (2 genes) Immune System Innate Immune System Toll-like Receptor Cascades Toll Like Receptor 4 (TLR4) Cascade Neutrophil degranulation 2 genes SLC15A4:TASL-dependent IRF5 activation (1 genes) Immune System Innate Immune System Toll-like Receptor Cascades Toll Like Receptor 9 (TLR9) Cascade SLC15A4:TASL-dependent IRF5 activation 1 genes The NLRP1 inflammasome (2 genes) Immune System Innate Immune System Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Inflammasomes The NLRP1 inflammasome 2 genes The NLRP3 inflammasome (1 genes) Immune System Innate Immune System Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Inflammasomes The NLRP3 inflammasome 1 genes CD209 (DC-SIGN) signaling (3 genes) Immune System Innate Immune System C-type lectin receptors (CLRs) CD209 (DC-SIGN) signaling 3 genes CLEC7A (Dectin-1) signaling (1 genes) Immune System Innate Immune System C-type lectin receptors (CLRs) CLEC7A (Dectin-1) signaling 1 genes Dectin-2 family (1 genes) Immune System Innate Immune System C-type lectin receptors (CLRs) Dectin-2 family 1 genes LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production (1 genes) Immune System Innate Immune System Cytosolic sensors of pathogen-associated DNA LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 1 genes NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 (1 genes) Immune System Innate Immune System DDX58/IFIH1-mediated induction of interferon-alpha/beta NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 1 genes Neutrophil degranulation (1 genes) Immune System Innate Immune System DAP12 interactions Neutrophil degranulation 1 genes Regulation of Complement cascade (2 genes) Immune System Innate Immune System Complement cascade Regulation of Complement cascade 2 genes Regulation of actin dynamics for phagocytic cup formation (1 genes) Immune System Innate Immune System Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation 1 genes Role of LAT2/NTAL/LAB on calcium mobilization (1 genes) Immune System Innate Immune System Fc epsilon receptor (FCERI) signaling Role of LAT2/NTAL/LAB on calcium mobilization 1 genes Trafficking and processing of endosomal TLR (1 genes) Immune System Innate Immune System Toll-like Receptor Cascades Trafficking and processing of endosomal TLR 1 genes Neutrophil degranulation (19 genes) Immune System Innate Immune System Neutrophil degranulation 19 genes ROS and RNS production in phagocytes (1 genes) Immune System Innate Immune System ROS and RNS production in phagocytes 1 genes	ABL1 Gene Information Basic Information Ensembl ID: ENSG00000097007 Description: ABL proto-oncogene 1%2C non-receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:76] Location: 9:130713043-130887675 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Innate Immune System Epigenetic regulation of gene expression Myogenesis ARG1 Gene Information Basic Information Ensembl ID: ENSG00000118520 Description: arginase 1 [Source:HGNC Symbol;Acc:HGNC:663] Location: 6:131470832-131584332 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Innate Immune System Metabolism of amino acids and derivatives BCL2 Gene Information Basic Information Ensembl ID: ENSG00000171791 Description: BCL2 apoptosis regulator [Source:HGNC Symbol;Acc:HGNC:990] Location: 18:63123346-63320128 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: cancer cell Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System BCL2L1 Gene Information Basic Information Ensembl ID: ENSG00000171552 Description: BCL2 like 1 [Source:HGNC Symbol;Acc:HGNC:992] Location: 20:31664452-31723989 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System BTK Gene Information Basic Information Ensembl ID: ENSG00000010671 Description: Bruton tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:1133] Location: X:101349338-101390796 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell Naive B cell mast cell granulocyte Other: Adaptive Immune System Innate Immune System Signaling by GPCR CARD11 Gene Information Basic Information Ensembl ID: ENSG00000198286 Description: caspase recruitment domain family member 11 [Source:HGNC Symbol;Acc:HGNC:16393] Location: 7:2906142-3044228 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell CD8+ T cell developing T cell dendritic cell lymphoid progenitor cell T cell Specialized T cell innate lymphoid cell leukocyte lymphocyte Other: Adaptive Immune System Innate Immune System CASP10 Gene Information Basic Information Ensembl ID: ENSG00000003400 Description: caspase 10 [Source:HGNC Symbol;Acc:HGNC:1500] Location: 2:201182872-201229428 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: plasma cell Other: Death Receptor Signaling Innate Immune System RNA Polymerase II Transcription CASP8 Gene Information Basic Information Ensembl ID: ENSG00000064012 Description: caspase 8 [Source:HGNC Symbol;Acc:HGNC:1509] Location: 2:201233443-201361836 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System CCL22 Gene Information Basic Information Ensembl ID: ENSG00000102962 Description: C-C motif chemokine ligand 22 [Source:HGNC Symbol;Acc:HGNC:10621] Location: 16:57358783-57366189 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell Specialized T cell Other: Cytokine Signaling in Immune system Innate Immune System Signaling by GPCR CCR2 Gene Information Basic Information Ensembl ID: ENSG00000121807 Description: C-C motif chemokine receptor 2 [Source:HGNC Symbol;Acc:HGNC:1603] Location: 3:46353864-46360940 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: plasma cell monocyte Other: Cytokine Signaling in Immune system Innate Immune System Signaling by GPCR CCR6 Gene Information Basic Information Ensembl ID: ENSG00000112486 Description: C-C motif chemokine receptor 6 [Source:HGNC Symbol;Acc:HGNC:1607] Location: 6:167111807-167139141 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell Regulatory T cell CD4+ T cell T cell memory B cell Other: Innate Immune System Signaling by GPCR CD14 Gene Information Basic Information Ensembl ID: ENSG00000170458 Description: CD14 molecule [Source:HGNC Symbol;Acc:HGNC:1628] Location: 5:140631728-140633700 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell macrophage dendritic cell phagocyte myeloid cell antigen presenting cell monocyte Other: Apoptosis Adaptive Immune System Innate Immune System CD19 Gene Information Basic Information Ensembl ID: ENSG00000177455 Description: CD19 molecule [Source:HGNC Symbol;Acc:HGNC:1633] Location: 16:28931965-28939342 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell Follicular B cell Regulatory plasma cell cancer cell follicular cell plasmablast memory B cell fibroblast Other: Adaptive Immune System Innate Immune System Intracellular signaling by second messengers CD209 Gene Information Basic Information Ensembl ID: ENSG00000090659 Description: CD209 molecule [Source:HGNC Symbol;Acc:HGNC:1641] Location: 19:7739993-7747564 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: phagocyte myeloid cell dendritic cell macrophage Other: Adaptive Immune System Innate Immune System Viral Infection Pathways CD33 Gene Information Basic Information Ensembl ID: ENSG00000105383 Description: CD33 molecule [Source:HGNC Symbol;Acc:HGNC:1659] Location: 19:51225064-51243860 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: mast cell myeloid cell myeloid derived suppressor cell blast cell peripheral blood mononuclear cell macrophage dendritic cell progenitor monocyte granulocyte Other: Adaptive Immune System Innate Immune System CD4 Gene Information Basic Information Ensembl ID: ENSG00000010610 Description: CD4 molecule [Source:HGNC Symbol;Acc:HGNC:1678] Location: 12:6786858-6820799 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell dendritic cell phagocyte CD4+ T cell antigen presenting cell hematopoietic cell monocyte macrophage developing T cell Regulatory T cell T cell memory T cell Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System CD47 Gene Information Basic Information Ensembl ID: ENSG00000196776 Description: CD47 molecule [Source:HGNC Symbol;Acc:HGNC:1682] Location: 3:108043091-108091862 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell pericyte epithelial cell T cell memory T cell endothelial cell megakaryocyte Other: Innate Immune System Cell surface interactions at the vascular wall Integrin cell surface interactions CD68 Gene Information Basic Information Ensembl ID: ENSG00000129226 Description: CD68 molecule [Source:HGNC Symbol;Acc:HGNC:1693] Location: 17:7579491-7582111 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell neuron dendritic cell macrophage phagocyte monocyte myeloid cell neutrophil microglia eosinophil immune cell kupffer cell Other: Innate Immune System CEACAM1 Gene Information Basic Information Ensembl ID: ENSG00000079385 Description: CEA cell adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:1814] Location: 19:42507304-42561234 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell epithelial cell stem cell myeloid cell secretory cell neutrophil trophoblast cell Other: Fibronectin matrix formation Innate Immune System Cell surface interactions at the vascular wall CHUK Gene Information Basic Information Ensembl ID: ENSG00000213341 Description: component of inhibitor of nuclear factor kappa B kinase complex [Source:HGNC Symbol;Acc:HGNC:1974] Location: 10:100188300-100229596 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Intracellular signaling by second messengers Cytokine Signaling in Immune system Adaptive Immune System CLEC5A Gene Information Basic Information Ensembl ID: ENSG00000258227 Description: C-type lectin domain containing 5A [Source:HGNC Symbol;Acc:HGNC:2054] Location: 7:141927357-141947007 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: monocyte Other: Innate Immune System CLEC7A Gene Information Basic Information Ensembl ID: ENSG00000172243 Description: C-type lectin domain containing 7A [Source:HGNC Symbol;Acc:HGNC:14558] Location: 12:10116777-10130258 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell macrophage phagocyte monocyte leukocyte neuron myeloid cell hematopoietic cell Other: Innate Immune System CR2 Gene Information Basic Information Ensembl ID: ENSG00000117322 Description: complement C3d receptor 2 [Source:HGNC Symbol;Acc:HGNC:2336] Location: 1:207453024-207489895 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: fibroblast Follicular B cell memory B cell dendritic cell Regulatory leukocyte Naive B cell Other: Innate Immune System CREBBP Gene Information Basic Information Ensembl ID: ENSG00000005339 Description: CREB binding protein [Source:HGNC Symbol;Acc:HGNC:2348] Location: 16:3725054-3880713 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes BMAL1:CLOCK,NPAS2 activates circadian expression CTNNB1 Gene Information Basic Information Ensembl ID: ENSG00000168036 Description: catenin beta 1 [Source:HGNC Symbol;Acc:HGNC:2514] Location: 3:41194741-41260096 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell endothelial cell epithelial cell stem cell phagocyte adrenal cortical cell fibroblast monocyte Specialized T cell melanocyte M cell Other: Apoptosis Innate Immune System Signaling by WNT CXCR1 Gene Information Basic Information Ensembl ID: ENSG00000163464 Description: C-X-C motif chemokine receptor 1 [Source:HGNC Symbol;Acc:HGNC:6026] Location: 2:218162841-218166962 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell platelet Other: Innate Immune System Signaling by GPCR CXCR2 Gene Information Basic Information Ensembl ID: ENSG00000180871 Description: C-X-C motif chemokine receptor 2 [Source:HGNC Symbol;Acc:HGNC:6027] Location: 2:218125289-218137251 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell neutrophil Other: Innate Immune System Signaling by GPCR CYLD Gene Information Basic Information Ensembl ID: ENSG00000083799 Description: CYLD lysine 63 deubiquitinase [Source:HGNC Symbol;Acc:HGNC:2584] Location: 16:50742050-50801935 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell developing T cell Specialized T cell Regulatory T cell Other: Innate Immune System Post-translational protein modification Death Receptor Signaling DUSP4 Gene Information Basic Information Ensembl ID: ENSG00000120875 Description: dual specificity phosphatase 4 [Source:HGNC Symbol;Acc:HGNC:3070] Location: 8:29333064-29350684 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell developing T cell Regulatory T cell Specialized T cell autonomic neuron Other: Cytokine Signaling in Immune system Innate Immune System MAPK family signaling cascades DUSP6 Gene Information Basic Information Ensembl ID: ENSG00000139318 Description: dual specificity phosphatase 6 [Source:HGNC Symbol;Acc:HGNC:3072] Location: 12:89347235-89352501 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell endothelial cell phagocyte mast cell monocyte granulocyte myeloid cell innate lymphoid cell Other: Cytokine Signaling in Immune system Innate Immune System MAPK family signaling cascades FADD Gene Information Basic Information Ensembl ID: ENSG00000168040 Description: Fas associated via death domain [Source:HGNC Symbol;Acc:HGNC:3573] Location: 11:70203296-70207390 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Innate Immune System Regulated Necrosis FCGR2A Gene Information Basic Information Ensembl ID: ENSG00000143226 Description: Fc gamma receptor IIa [Source:HGNC Symbol;Acc:HGNC:3616] Location: 1:161505430-161524013 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell neuron macrophage dendritic cell phagocyte microglia myeloid cell antigen presenting cell monocyte Other: Parasitic Infection Pathways Innate Immune System FYN Gene Information Basic Information Ensembl ID: ENSG00000010810 Description: FYN proto-oncogene%2C Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:4037] Location: 6:111660332-111873452 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Cellular responses to mechanical stimuli HRAS Gene Information Basic Information Ensembl ID: ENSG00000174775 Description: HRas proto-oncogene%2C GTPase [Source:HGNC Symbol;Acc:HGNC:5173] Location: 11:532242-537321 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Transmission across Chemical Synapses Cytokine Signaling in Immune system Adaptive Immune System ICAM2 Gene Information Basic Information Ensembl ID: ENSG00000108622 Description: intercellular adhesion molecule 2 [Source:HGNC Symbol;Acc:HGNC:5345] Location: 17:64002594-64020634 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell cardiomyocyte megakaryocyte Other: Adaptive Immune System Innate Immune System Integrin cell surface interactions ICAM3 Gene Information Basic Information Ensembl ID: ENSG00000076662 Description: intercellular adhesion molecule 3 [Source:HGNC Symbol;Acc:HGNC:5346] Location: 19:10333776-10339661 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell developing T cell hematopoietic stem cell CD4+ T cell Specialized T cell monocyte innate lymphoid cell lymphocyte Other: Adaptive Immune System Innate Immune System Integrin cell surface interactions IDH1 Gene Information Basic Information Ensembl ID: ENSG00000138413 Description: isocitrate dehydrogenase (NADP(+)) 1 [Source:HGNC Symbol;Acc:HGNC:5382] Location: 2:208236229-208266074 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Innate Immune System Metabolism of vitamins and cofactors Cellular responses to stress IFIH1 Gene Information Basic Information Ensembl ID: ENSG00000115267 Description: interferon induced with helicase C domain 1 [Source:HGNC Symbol;Acc:HGNC:18873] Location: 2:162267074-162318684 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: antigen presenting cell Other: Cytokine Signaling in Immune system Innate Immune System Post-translational protein modification IFNB1 Gene Information Basic Information Ensembl ID: ENSG00000171855 Description: interferon beta 1 [Source:HGNC Symbol;Acc:HGNC:5434] Location: 9:21077104-21077942 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Innate Immune System Cellular responses to stress IGF2R Gene Information Basic Information Ensembl ID: ENSG00000197081 Description: insulin like growth factor 2 receptor [Source:HGNC Symbol;Acc:HGNC:5467] Location: 6:159969082-160113507 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell granulocyte neutrophil myeloid cell dendritic cell Other: Innate Immune System Membrane Trafficking IKBKB Gene Information Basic Information Ensembl ID: ENSG00000104365 Description: inhibitor of nuclear factor kappa B kinase subunit beta [Source:HGNC Symbol;Acc:HGNC:5960] Location: 8:42271302-42332460 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell secretory cell T cell Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System IL1B Gene Information Basic Information Ensembl ID: ENSG00000125538 Description: interleukin 1 beta [Source:HGNC Symbol;Acc:HGNC:5992] Location: 2:112829751-112836816 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell neuron macrophage dendritic cell phagocyte monocyte progenitor cell myeloid cell antigen presenting cell Other: Regulated Necrosis Cytokine Signaling in Immune system Innate Immune System IRAK1 Gene Information Basic Information Ensembl ID: ENSG00000184216 Description: interleukin 1 receptor associated kinase 1 [Source:HGNC Symbol;Acc:HGNC:6112] Location: X:154010506-154019902 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: monocyte Other: Cytokine Signaling in Immune system Innate Immune System RNA Polymerase II Transcription IRAK2 Gene Information Basic Information Ensembl ID: ENSG00000134070 Description: interleukin 1 receptor associated kinase 2 [Source:HGNC Symbol;Acc:HGNC:6113] Location: 3:10164919-10243745 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell granulocyte Other: Cytokine Signaling in Immune system Innate Immune System Viral Infection Pathways IRAK3 Gene Information Basic Information Ensembl ID: ENSG00000090376 Description: interleukin 1 receptor associated kinase 3 [Source:HGNC Symbol;Acc:HGNC:17020] Location: 12:66189195-66254622 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell macrophage phagocyte monocyte granulocyte neutrophil antigen presenting cell Other: Cytokine Signaling in Immune system Innate Immune System IRAK4 Gene Information Basic Information Ensembl ID: ENSG00000198001 Description: interleukin 1 receptor associated kinase 4 [Source:HGNC Symbol;Acc:HGNC:17967] Location: 12:43758944-43798307 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Innate Immune System Intracellular signaling by second messengers IRF3 Gene Information Basic Information Ensembl ID: ENSG00000126456 Description: interferon regulatory factor 3 [Source:HGNC Symbol;Acc:HGNC:6118] Location: 19:49659569-49665875 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Innate Immune System Viral Infection Pathways IRF5 Gene Information Basic Information Ensembl ID: ENSG00000128604 Description: interferon regulatory factor 5 [Source:HGNC Symbol;Acc:HGNC:6120] Location: 7:128937457-128950038 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Innate Immune System ITGAL Gene Information Basic Information Ensembl ID: ENSG00000005844 Description: integrin subunit alpha L [Source:HGNC Symbol;Acc:HGNC:6148] Location: 16:30472658-30523567 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell developing T cell T cell Specialized T cell CD4+ T cell lymphoid progenitor cell CD8+ T cell natural killer cell innate lymphoid cell leukocyte monocyte Other: Adaptive Immune System Innate Immune System Cell surface interactions at the vascular wall ITGAM Gene Information Basic Information Ensembl ID: ENSG00000169896 Description: integrin subunit alpha M [Source:HGNC Symbol;Acc:HGNC:6149] Location: 16:31259967-31332892 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: granulocyte hematopoietic cell dendritic cell myeloid derived suppressor cell monocyte eosinophil neutrophil Other: Cytokine Signaling in Immune system Innate Immune System Cell surface interactions at the vascular wall ITGAV Gene Information Basic Information Ensembl ID: ENSG00000138448 Description: integrin subunit alpha V [Source:HGNC Symbol;Acc:HGNC:6150] Location: 2:186590010-186680901 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell glial cell stromal cell M cell endothelial cell Other: Adaptive Immune System Elastic fibre formation Innate Immune System ITGAX Gene Information Basic Information Ensembl ID: ENSG00000140678 Description: integrin subunit alpha X [Source:HGNC Symbol;Acc:HGNC:6152] Location: 16:31355134-31382999 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell natural killer cell phagocyte mast cell monocyte granulocyte dendritic cell Other: Cytokine Signaling in Immune system Innate Immune System Cell surface interactions at the vascular wall ITGB2 Gene Information Basic Information Ensembl ID: ENSG00000160255 Description: integrin subunit beta 2 [Source:HGNC Symbol;Acc:HGNC:6155] Location: 21:44885953-44931989 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell natural killer cell memory T cell developing T cell macrophage dendritic cell phagocyte leukocyte T cell Specialized T cell monocyte Other: Adaptive Immune System Cytokine Signaling in Immune system Innate Immune System ITK Gene Information Basic Information Ensembl ID: ENSG00000113263 Description: IL2 inducible T cell kinase [Source:HGNC Symbol;Acc:HGNC:6171] Location: 5:157142933-157255185 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell CD8+ T cell developing T cell T cell CD4+ T cell cytotoxic lymphocyte cancer cell Other: Adaptive Immune System Innate Immune System KLRK1 Gene Information Basic Information Ensembl ID: ENSG00000213809 Description: killer cell lectin like receptor K1 [Source:HGNC Symbol;Acc:HGNC:18788] Location: 12:10372353-10391874 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell CD8+ T cell memory T cell developing T cell Other: Adaptive Immune System Innate Immune System KRAS Gene Information Basic Information Ensembl ID: ENSG00000133703 Description: KRAS proto-oncogene%2C GTPase [Source:HGNC Symbol;Acc:HGNC:6407] Location: 12:25205246-25250936 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Signaling by Non-Receptor Tyrosine Kinases Transmission across Chemical Synapses Cytokine Signaling in Immune system LAIR1 Gene Information Basic Information Ensembl ID: ENSG00000167613 Description: leukocyte associated immunoglobulin like receptor 1 [Source:HGNC Symbol;Acc:HGNC:6477] Location: 19:54351384-54370558 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: macrophage monocyte Naive B cell leukocyte Other: Adaptive Immune System Innate Immune System LCK Gene Information Basic Information Ensembl ID: ENSG00000182866 Description: LCK proto-oncogene%2C Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6524] Location: 1:32251244-32286165 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell CD8+ T cell developing T cell T cell lymphocyte Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System LYN Gene Information Basic Information Ensembl ID: ENSG00000254087 Description: LYN proto-oncogene%2C Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6735] Location: 8:55879835-56014169 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System MAP2K1 Gene Information Basic Information Ensembl ID: ENSG00000169032 Description: mitogen-activated protein kinase kinase 1 [Source:HGNC Symbol;Acc:HGNC:6840] Location: 15:66386837-66491656 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Innate Immune System MAPK family signaling cascades MAP2K4 Gene Information Basic Information Ensembl ID: ENSG00000065559 Description: mitogen-activated protein kinase kinase 4 [Source:HGNC Symbol;Acc:HGNC:6844] Location: 17:12020829-12143830 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stem cell Other: Cytokine Signaling in Immune system Innate Immune System Cellular responses to stress MAPK1 Gene Information Basic Information Ensembl ID: ENSG00000100030 Description: mitogen-activated protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:6871] Location: 22:21759657-21867680 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Transmission across Chemical Synapses Signaling by NODAL MAPK14 Gene Information Basic Information Ensembl ID: ENSG00000112062 Description: mitogen-activated protein kinase 14 [Source:HGNC Symbol;Acc:HGNC:6876] Location: 6:36027752-36122511 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Platelet homeostasis Cytokine Signaling in Immune system Mitochondrial biogenesis MAPK3 Gene Information Basic Information Ensembl ID: ENSG00000102882 Description: mitogen-activated protein kinase 3 [Source:HGNC Symbol;Acc:HGNC:6877] Location: 16:30114105-30123506 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Transmission across Chemical Synapses Signaling by NODAL MAPK8 Gene Information Basic Information Ensembl ID: ENSG00000107643 Description: mitogen-activated protein kinase 8 [Source:HGNC Symbol;Acc:HGNC:6881] Location: 10:48306639-48439360 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System MMP9 Gene Information Basic Information Ensembl ID: ENSG00000100985 Description: matrix metallopeptidase 9 [Source:HGNC Symbol;Acc:HGNC:7176] Location: 20:46008908-46016561 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell macrophage phagocyte neutrophil monocyte osteoclast Other: Cytokine Signaling in Immune system Degradation of the extracellular matrix Collagen formation MPO Gene Information Basic Information Ensembl ID: ENSG00000005381 Description: myeloperoxidase [Source:HGNC Symbol;Acc:HGNC:7218] Location: 17:58269855-58280935 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell myeloid cell bone cell granulocyte neutrophil Other: Innate Immune System MS4A2 Gene Information Basic Information Ensembl ID: ENSG00000149534 Description: membrane spanning 4-domains A2 [Source:HGNC Symbol;Acc:HGNC:7316] Location: 11:60088261-60098467 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell mast cell Other: Innate Immune System MUC1 Gene Information Basic Information Ensembl ID: ENSG00000185499 Description: mucin 1%2C cell surface associated [Source:HGNC Symbol;Acc:HGNC:7508] Location: 1:155185824-155192916 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell pneumocyte goblet cell enterocyte secretory cell cancer cell Other: Cytokine Signaling in Immune system Innate Immune System Post-translational protein modification MYD88 Gene Information Basic Information Ensembl ID: ENSG00000172936 Description: MYD88 innate immune signal transduction adaptor [Source:HGNC Symbol;Acc:HGNC:7562] Location: 3:38138552-38143024 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: monocyte Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System NFATC1 Gene Information Basic Information Ensembl ID: ENSG00000131196 Description: nuclear factor of activated T cells 1 [Source:HGNC Symbol;Acc:HGNC:7775] Location: 18:79395856-79529325 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell endocardial cell Other: Adaptive Immune System Innate Immune System Signaling by WNT NFKB1 Gene Information Basic Information Ensembl ID: ENSG00000109320 Description: nuclear factor kappa B subunit 1 [Source:HGNC Symbol;Acc:HGNC:7794] Location: 4:102501330-102617302 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System NFKB2 Gene Information Basic Information Ensembl ID: ENSG00000077150 Description: nuclear factor kappa B subunit 2 [Source:HGNC Symbol;Acc:HGNC:7795] Location: 10:102394110-102402524 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: CD4+ T cell Other: Cytokine Signaling in Immune system Innate Immune System Chromatin modifying enzymes NLRC5 Gene Information Basic Information Ensembl ID: ENSG00000140853 Description: NLR family CARD domain containing 5 [Source:HGNC Symbol;Acc:HGNC:29933] Location: 16:56989485-57083531 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: CD8+ T cell developing T cell T cell Other: Cytokine Signaling in Immune system Innate Immune System NLRP3 Gene Information Basic Information Ensembl ID: ENSG00000162711 Description: NLR family pyrin domain containing 3 [Source:HGNC Symbol;Acc:HGNC:16400] Location: 1:247332331-247449108 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell dendritic cell phagocyte monocyte Other: Parasitic Infection Pathways Viral Infection Pathways Innate Immune System NOS2 Gene Information Basic Information Ensembl ID: ENSG00000007171 Description: nitric oxide synthase 2 [Source:HGNC Symbol;Acc:HGNC:7873] Location: 17:27756766-27800529 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Innate Immune System Platelet homeostasis NRAS Gene Information Basic Information Ensembl ID: ENSG00000213281 Description: NRAS proto-oncogene%2C GTPase [Source:HGNC Symbol;Acc:HGNC:7989] Location: 1:114704469-114716771 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell cancer cell Other: Signaling by Erythropoietin Signaling by Non-Receptor Tyrosine Kinases Signaling by Nuclear Receptors PECAM1 Gene Information Basic Information Ensembl ID: ENSG00000261371 Description: platelet and endothelial cell adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:8823] Location: 17:64319415-64413776 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell neuron fibroblast monocyte pericyte smooth muscle cell endocrine cell epithelial cell platelet immune cell stromal cell hematopoietic stem cell lymphocyte mesenchymal stem cell endocardial cell Other: Innate Immune System Cell surface interactions at the vascular wall Integrin cell surface interactions PIK3CA Gene Information Basic Information Ensembl ID: ENSG00000121879 Description: phosphatidylinositol-4%2C5-bisphosphate 3-kinase catalytic subunit alpha [Source:HGNC Symbol;Acc:HGNC:8975] Location: 3:179148114-179240093 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System PLAU Gene Information Basic Information Ensembl ID: ENSG00000122861 Description: plasminogen activator%2C urokinase [Source:HGNC Symbol;Acc:HGNC:9052] Location: 10:73909177-73917496 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell stem cell mast cell neutrophil goblet cell Other: Innate Immune System Dissolution of Fibrin Clot PTPN11 Gene Information Basic Information Ensembl ID: ENSG00000179295 Description: protein tyrosine phosphatase non-receptor type 11 [Source:HGNC Symbol;Acc:HGNC:9644] Location: 12:112418351-112509918 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System PTPRC Gene Information Basic Information Ensembl ID: ENSG00000081237 Description: protein tyrosine phosphatase receptor type C [Source:HGNC Symbol;Acc:HGNC:9666] Location: 1:198638457-198759342 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell CD8+ T cell developing T cell T cell phagocyte monocyte CD4+ T cell leukocyte hematopoietic cell lymphocyte hematopoietic stem cell stromal cell fibroblast immune cell myeloid cell dendritic cell plasma cell neutrophil mesenchymal stem cell epithelial cell endothelial cell macrophage mast cell stem cell Other: Adaptive Immune System Innate Immune System Nervous system development RELA Gene Information Basic Information Ensembl ID: ENSG00000173039 Description: RELA proto-oncogene%2C NF-kB subunit [Source:HGNC Symbol;Acc:HGNC:9955] Location: 11:65653599-65663090 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System RIGI Gene Information Basic Information Ensembl ID: ENSG00000107201 Description: RNA sensor RIG-I [Source:HGNC Symbol;Acc:HGNC:19102] Location: 9:32455302-32526348 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Innate Immune System Post-translational protein modification SELL Gene Information Basic Information Ensembl ID: ENSG00000188404 Description: selectin L [Source:HGNC Symbol;Acc:HGNC:10720] Location: 1:169690665-169711702 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell memory T cell Regulatory T cell Naive B cell T cell dendritic cell lymphoid progenitor cell granulocyte Follicular B cell antigen presenting cell memory B cell monocyte innate lymphoid cell developing T cell neutrophil Other: Adaptive Immune System Innate Immune System Cell surface interactions at the vascular wall STAT6 Gene Information Basic Information Ensembl ID: ENSG00000166888 Description: signal transducer and activator of transcription 6 [Source:HGNC Symbol;Acc:HGNC:11368] Location: 12:57095408-57132139 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: secretory cell Other: Cytokine Signaling in Immune system Innate Immune System Signaling by Receptor Tyrosine Kinases STING1 Gene Information Basic Information Ensembl ID: ENSG00000184584 Description: stimulator of interferon response cGAMP interactor 1 [Source:HGNC Symbol;Acc:HGNC:27962] Location: 5:139475533-139482935 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Viral Infection Pathways Innate Immune System SYK Gene Information Basic Information Ensembl ID: ENSG00000165025 Description: spleen associated tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:11491] Location: 9:90801787-90898549 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell phagocyte microglia Follicular B cell myeloid cell antigen presenting cell hematopoietic cell dendritic cell macrophage Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System TBK1 Gene Information Basic Information Ensembl ID: ENSG00000183735 Description: TANK binding kinase 1 [Source:HGNC Symbol;Acc:HGNC:11584] Location: 12:64452090-64502114 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell Other: Cytokine Signaling in Immune system Macroautophagy Innate Immune System TICAM1 Gene Information Basic Information Ensembl ID: ENSG00000127666 Description: TIR domain containing adaptor molecule 1 [Source:HGNC Symbol;Acc:HGNC:18348] Location: 19:4815932-4831712 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Innate Immune System Diseases associated with the TLR signaling cascade TLR1 Gene Information Basic Information Ensembl ID: ENSG00000174125 Description: toll like receptor 1 [Source:HGNC Symbol;Acc:HGNC:11847] Location: 4:38787555-38856817 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Adaptive Immune System Innate Immune System Diseases associated with the TLR signaling cascade TLR2 Gene Information Basic Information Ensembl ID: ENSG00000137462 Description: toll like receptor 2 [Source:HGNC Symbol;Acc:HGNC:11848] Location: 4:153684050-153706260 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell macrophage phagocyte microglia granulocyte neutrophil Other: Adaptive Immune System Innate Immune System Diseases associated with the TLR signaling cascade TLR3 Gene Information Basic Information Ensembl ID: ENSG00000164342 Description: toll like receptor 3 [Source:HGNC Symbol;Acc:HGNC:11849] Location: 4:186068911-186088073 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Innate Immune System Diseases associated with the TLR signaling cascade Viral Infection Pathways TLR4 Gene Information Basic Information Ensembl ID: ENSG00000136869 Description: toll like receptor 4 [Source:HGNC Symbol;Acc:HGNC:11850] Location: 9:117704175-117724735 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell myeloid cell Other: Apoptosis Adaptive Immune System Innate Immune System TLR5 Gene Information Basic Information Ensembl ID: ENSG00000187554 Description: toll like receptor 5 [Source:HGNC Symbol;Acc:HGNC:11851] Location: 1:223109404-223143292 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Diseases associated with the TLR signaling cascade Innate Immune System TLR7 Gene Information Basic Information Ensembl ID: ENSG00000196664 Description: toll like receptor 7 [Source:HGNC Symbol;Acc:HGNC:15631] Location: X:12867072-12890361 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell Other: Diseases associated with the TLR signaling cascade Viral Infection Pathways Innate Immune System TLR8 Gene Information Basic Information Ensembl ID: ENSG00000101916 Description: toll like receptor 8 [Source:HGNC Symbol;Acc:HGNC:15632] Location: X:12906620-12923169 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Viral Infection Pathways Innate Immune System TLR9 Gene Information Basic Information Ensembl ID: ENSG00000239732 Description: toll like receptor 9 [Source:HGNC Symbol;Acc:HGNC:15633] Location: 3:52221080-52225645 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Innate Immune System Signaling by Receptor Tyrosine Kinases Viral Infection Pathways TNFRSF1B Gene Information Basic Information Ensembl ID: ENSG00000028137 Description: TNF receptor superfamily member 1B [Source:HGNC Symbol;Acc:HGNC:11917] Location: 1:12166991-12209228 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell natural killer cell macrophage Regulatory T cell phagocyte microglia leukocyte monocyte granulocyte T cell dendritic cell Other: Cytokine Signaling in Immune system Innate Immune System TP53 Gene Information Basic Information Ensembl ID: ENSG00000141510 Description: tumor protein p53 [Source:HGNC Symbol;Acc:HGNC:11998] Location: 17:7661779-7687546 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Cytokine Signaling in Immune system Signaling by NOTCH TRAF2 Gene Information Basic Information Ensembl ID: ENSG00000127191 Description: TNF receptor associated factor 2 [Source:HGNC Symbol;Acc:HGNC:12032] Location: 9:136881912-136929221 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System TREM2 Gene Information Basic Information Ensembl ID: ENSG00000095970 Description: triggering receptor expressed on myeloid cells 2 [Source:HGNC Symbol;Acc:HGNC:17761] Location: 6:41158506-41163186 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron macrophage dendritic cell phagocyte monocyte antigen presenting cell microglia Other: Adaptive Immune System Innate Immune System Nervous system development
Integration of energy metabolism Pathway Hierarchies & Genes Acetylcholine regulates insulin secretion (1 genes) Metabolism Integration of energy metabolism Regulation of insulin secretion Acetylcholine regulates insulin secretion 1 genes	PRKCA Gene Information Basic Information Ensembl ID: ENSG00000154229 Description: protein kinase C alpha [Source:HGNC Symbol;Acc:HGNC:9393] Location: 17:66302613-66810743 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: bipolar cell Other: Transmission across Chemical Synapses Integration of energy metabolism Signaling by WNT
Integrin cell surface interactions Pathway Hierarchies & Genes Integrin cell surface interactions (26 genes) Extracellular matrix organization Integrin cell surface interactions 26 genes	CD47 Gene Information Basic Information Ensembl ID: ENSG00000196776 Description: CD47 molecule [Source:HGNC Symbol;Acc:HGNC:1682] Location: 3:108043091-108091862 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell pericyte epithelial cell T cell memory T cell endothelial cell megakaryocyte Other: Innate Immune System Cell surface interactions at the vascular wall Integrin cell surface interactions CDH1 Gene Information Basic Information Ensembl ID: ENSG00000039068 Description: cadherin 1 [Source:HGNC Symbol;Acc:HGNC:1748] Location: 16:68737292-68835537 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: goblet cell epithelial cell pneumocyte stem cell secretory cell tuft cell paneth cell ciliated cell neuroendocrine cell brush cell basal cell serous cell deuterosomal cell club Other: Apoptosis Adaptive Immune System Degradation of the extracellular matrix COL5A1 Gene Information Basic Information Ensembl ID: ENSG00000130635 Description: collagen type V alpha 1 chain [Source:HGNC Symbol;Acc:HGNC:2209] Location: 9:134641803-134844843 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron pericyte stromal cell stellate cell fibroblast stem cell embryonic cell mesenchymal cell skeletal muscle cell Other: Degradation of the extracellular matrix Collagen formation Fibronectin matrix formation FN1 Gene Information Basic Information Ensembl ID: ENSG00000115414 Description: fibronectin 1 [Source:HGNC Symbol;Acc:HGNC:3778] Location: 2:215360440-215436073 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell fibroblast endocrine cell pericyte epithelial cell stellate cell stem cell phagocyte muscle cell stromal cell smooth muscle cell thymic epithelial cell skeletal muscle cell mesenchymal cell Other: Cytokine Signaling in Immune system Degradation of the extracellular matrix Elastic fibre formation ICAM1 Gene Information Basic Information Ensembl ID: ENSG00000090339 Description: intercellular adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:5344] Location: 19:10271093-10286615 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell endothelial cell natural killer cell dendritic cell phagocyte stromal cell pancreatic cell granulocyte macrophage kupffer cell fibroblast Other: Cytokine Signaling in Immune system Adaptive Immune System Integrin cell surface interactions ICAM2 Gene Information Basic Information Ensembl ID: ENSG00000108622 Description: intercellular adhesion molecule 2 [Source:HGNC Symbol;Acc:HGNC:5345] Location: 17:64002594-64020634 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell cardiomyocyte megakaryocyte Other: Adaptive Immune System Innate Immune System Integrin cell surface interactions ICAM3 Gene Information Basic Information Ensembl ID: ENSG00000076662 Description: intercellular adhesion molecule 3 [Source:HGNC Symbol;Acc:HGNC:5346] Location: 19:10333776-10339661 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell developing T cell hematopoietic stem cell CD4+ T cell Specialized T cell monocyte innate lymphoid cell lymphocyte Other: Adaptive Immune System Innate Immune System Integrin cell surface interactions ITGA1 Gene Information Basic Information Ensembl ID: ENSG00000213949 Description: integrin subunit alpha 1 [Source:HGNC Symbol;Acc:HGNC:6134] Location: 5:52787916-52959209 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell pericyte developing T cell epithelial cell fibroblast glial cell stromal cell Specialized T cell smooth muscle cell CD8+ T cell T cell mesenchymal cell lymphocyte beta cell memory T cell Other: Integrin cell surface interactions Laminin interactions Smooth Muscle Contraction ITGA2 Gene Information Basic Information Ensembl ID: ENSG00000164171 Description: integrin subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:6137] Location: 5:52989340-53094779 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell stem cell pancreatic cell goblet cell Other: Integrin cell surface interactions Laminin interactions Non-integrin membrane-ECM interactions ITGA4 Gene Information Basic Information Ensembl ID: ENSG00000115232 Description: integrin subunit alpha 4 [Source:HGNC Symbol;Acc:HGNC:6140] Location: 2:181457202-181538940 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell developing T cell Naive B cell Specialized T cell mast cell lymphoid progenitor cell CD8+ T cell erythroid lineage cell T cell memory T cell progenitor cell erythroblast projection neuron Other: Cell surface interactions at the vascular wall Integrin cell surface interactions Adaptive Immune System ITGA5 Gene Information Basic Information Ensembl ID: ENSG00000161638 Description: integrin subunit alpha 5 [Source:HGNC Symbol;Acc:HGNC:6141] Location: 12:54395261-54419266 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell epithelial cell stromal cell smooth muscle cell trophoblast cell mesenchymal stem cell fibroblast Other: Elastic fibre formation Fibronectin matrix formation Cell surface interactions at the vascular wall ITGA6 Gene Information Basic Information Ensembl ID: ENSG00000091409 Description: integrin subunit alpha 6 [Source:HGNC Symbol;Acc:HGNC:6142] Location: 2:172234216-172506459 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell goblet cell kidney cell pericyte epithelial cell embryonic cell stem cell glial cell stromal cell Other: Collagen formation Cell surface interactions at the vascular wall Integrin cell surface interactions ITGAE Gene Information Basic Information Ensembl ID: ENSG00000083457 Description: integrin subunit alpha E [Source:HGNC Symbol;Acc:HGNC:6147] Location: 17:3714628-3801188 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell CD8+ T cell memory T cell dendritic cell T cell natural killer cell developing T cell Other: Integrin cell surface interactions ITGAL Gene Information Basic Information Ensembl ID: ENSG00000005844 Description: integrin subunit alpha L [Source:HGNC Symbol;Acc:HGNC:6148] Location: 16:30472658-30523567 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell developing T cell T cell Specialized T cell CD4+ T cell lymphoid progenitor cell CD8+ T cell natural killer cell innate lymphoid cell leukocyte monocyte Other: Adaptive Immune System Innate Immune System Cell surface interactions at the vascular wall ITGAM Gene Information Basic Information Ensembl ID: ENSG00000169896 Description: integrin subunit alpha M [Source:HGNC Symbol;Acc:HGNC:6149] Location: 16:31259967-31332892 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: granulocyte hematopoietic cell dendritic cell myeloid derived suppressor cell monocyte eosinophil neutrophil Other: Cytokine Signaling in Immune system Innate Immune System Cell surface interactions at the vascular wall ITGAV Gene Information Basic Information Ensembl ID: ENSG00000138448 Description: integrin subunit alpha V [Source:HGNC Symbol;Acc:HGNC:6150] Location: 2:186590010-186680901 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell glial cell stromal cell M cell endothelial cell Other: Adaptive Immune System Elastic fibre formation Innate Immune System ITGAX Gene Information Basic Information Ensembl ID: ENSG00000140678 Description: integrin subunit alpha X [Source:HGNC Symbol;Acc:HGNC:6152] Location: 16:31355134-31382999 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell natural killer cell phagocyte mast cell monocyte granulocyte dendritic cell Other: Cytokine Signaling in Immune system Innate Immune System Cell surface interactions at the vascular wall ITGB1 Gene Information Basic Information Ensembl ID: ENSG00000150093 Description: integrin subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:6153] Location: 10:32887273-33005792 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stellate cell pericyte trophoblast cell epithelial cell stromal cell stem cell endothelial cell smooth muscle cell fibroblast mesenchymal stem cell Other: Laminin interactions Cell surface interactions at the vascular wall Cytokine Signaling in Immune system ITGB2 Gene Information Basic Information Ensembl ID: ENSG00000160255 Description: integrin subunit beta 2 [Source:HGNC Symbol;Acc:HGNC:6155] Location: 21:44885953-44931989 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell natural killer cell memory T cell developing T cell macrophage dendritic cell phagocyte leukocyte T cell Specialized T cell monocyte Other: Adaptive Immune System Cytokine Signaling in Immune system Innate Immune System ITGB3 Gene Information Basic Information Ensembl ID: ENSG00000259207 Description: integrin subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:6156] Location: 17:47253827-47313743 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: platelet epithelial cell monocyte Other: ECM proteoglycans Elastic fibre formation Cell surface interactions at the vascular wall ITGB7 Gene Information Basic Information Ensembl ID: ENSG00000139626 Description: integrin subunit beta 7 [Source:HGNC Symbol;Acc:HGNC:6162] Location: 12:53191323-53207282 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: CD4+ T cell T cell memory T cell Other: Adaptive Immune System Integrin cell surface interactions ITGB8 Gene Information Basic Information Ensembl ID: ENSG00000105855 Description: integrin subunit beta 8 [Source:HGNC Symbol;Acc:HGNC:6163] Location: 7:20330702-20415754 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell neuron pericyte embryonic cell trophoblast cell glial cell stromal cell schwann cell Other: Elastic fibre formation Integrin cell surface interactions Signaling by TGFB family members KDR Gene Information Basic Information Ensembl ID: ENSG00000128052 Description: kinase insert domain receptor [Source:HGNC Symbol;Acc:HGNC:6307] Location: 4:55078481-55125595 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell glial cell stromal cell mesothelial cell cancer stem cell Other: Integrin cell surface interactions Signaling by Receptor Tyrosine Kinases Cellular responses to mechanical stimuli PECAM1 Gene Information Basic Information Ensembl ID: ENSG00000261371 Description: platelet and endothelial cell adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:8823] Location: 17:64319415-64413776 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell neuron fibroblast monocyte pericyte smooth muscle cell endocrine cell epithelial cell platelet immune cell stromal cell hematopoietic stem cell lymphocyte mesenchymal stem cell endocardial cell Other: Innate Immune System Cell surface interactions at the vascular wall Integrin cell surface interactions THBS1 Gene Information Basic Information Ensembl ID: ENSG00000137801 Description: thrombospondin 1 [Source:HGNC Symbol;Acc:HGNC:11785] Location: 15:39581079-39599466 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell epithelial cell macrophage fibroblast phagocyte stromal cell smooth muscle cell monocyte neutrophil megakaryocyte pericyte Other: Diseases of glycosylation Integrin cell surface interactions Non-integrin membrane-ECM interactions VCAM1 Gene Information Basic Information Ensembl ID: ENSG00000162692 Description: vascular cell adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:12663] Location: 1:100719742-100739045 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell stromal cell monocyte stem cell fibroblast Specialized T cell epithelial cell dendritic cell macrophage adipocyte mesenchymal stem cell cardiomyocyte Other: Cytokine Signaling in Immune system Adaptive Immune System Integrin cell surface interactions
Integrin signaling Pathway Hierarchies & Genes p130Cas linkage to MAPK signaling for integrins (4 genes) Signal Transduction Integrin signaling 2 genes GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins 2 genes	AKT1 Gene Information Basic Information Ensembl ID: ENSG00000142208 Description: AKT serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:391] Location: 14:104769349-104795759 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Integrin signaling Apoptosis Cytokine Signaling in Immune system FN1 Gene Information Basic Information Ensembl ID: ENSG00000115414 Description: fibronectin 1 [Source:HGNC Symbol;Acc:HGNC:3778] Location: 2:215360440-215436073 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell fibroblast endocrine cell pericyte epithelial cell stellate cell stem cell phagocyte muscle cell stromal cell smooth muscle cell thymic epithelial cell skeletal muscle cell mesenchymal cell Other: Cytokine Signaling in Immune system Degradation of the extracellular matrix Elastic fibre formation ITGB3 Gene Information Basic Information Ensembl ID: ENSG00000259207 Description: integrin subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:6156] Location: 17:47253827-47313743 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: platelet epithelial cell monocyte Other: ECM proteoglycans Elastic fibre formation Cell surface interactions at the vascular wall SYK Gene Information Basic Information Ensembl ID: ENSG00000165025 Description: spleen associated tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:11491] Location: 9:90801787-90898549 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell phagocyte microglia Follicular B cell myeloid cell antigen presenting cell hematopoietic cell dendritic cell macrophage Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System
Intracellular signaling by second messengers Pathway Hierarchies & Genes Calmodulin induced events (1 genes) Signal Transduction Intracellular signaling by second messengers DAG and IP3 signaling CaM pathway Calmodulin induced events 1 genes PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (37 genes) Signal Transduction Intracellular signaling by second messengers PIP3 activates AKT signaling Negative regulation of the PI3K/AKT network PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 37 genes Regulation of PTEN gene transcription (6 genes) Signal Transduction Intracellular signaling by second messengers PIP3 activates AKT signaling PTEN Regulation Regulation of PTEN gene transcription 6 genes Regulation of PTEN stability and activity (2 genes) Signal Transduction Intracellular signaling by second messengers PIP3 activates AKT signaling PTEN Regulation Regulation of PTEN stability and activity 2 genes AKT phosphorylates targets in the cytosol (2 genes) Signal Transduction Intracellular signaling by second messengers PIP3 activates AKT signaling AKT phosphorylates targets in the cytosol 2 genes AKT phosphorylates targets in the nucleus (1 genes) Signal Transduction Intracellular signaling by second messengers PIP3 activates AKT signaling AKT phosphorylates targets in the nucleus 1 genes	AKT1 Gene Information Basic Information Ensembl ID: ENSG00000142208 Description: AKT serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:391] Location: 14:104769349-104795759 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Integrin signaling Apoptosis Cytokine Signaling in Immune system AKT2 Gene Information Basic Information Ensembl ID: ENSG00000105221 Description: AKT serine/threonine kinase 2 [Source:HGNC Symbol;Acc:HGNC:392] Location: 19:40230317-40285536 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: T cell Other: Apoptosis Cytokine Signaling in Immune system Adaptive Immune System AKT3 Gene Information Basic Information Ensembl ID: ENSG00000117020 Description: AKT serine/threonine kinase 3 [Source:HGNC Symbol;Acc:HGNC:393] Location: 1:243488233-243851079 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell neuron epithelial cell T cell fibroblast glial cell CD8+ T cell schwann cell Specialized T cell excitatory neuron smooth muscle cell Other: Apoptosis Cytokine Signaling in Immune system Adaptive Immune System BMI1 Gene Information Basic Information Ensembl ID: ENSG00000168283 Description: BMI1 proto-oncogene%2C polycomb ring finger [Source:HGNC Symbol;Acc:HGNC:1066] Location: 10:22321099-22331484 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cellular responses to stress Post-translational protein modification RNA Polymerase II Transcription CD19 Gene Information Basic Information Ensembl ID: ENSG00000177455 Description: CD19 molecule [Source:HGNC Symbol;Acc:HGNC:1633] Location: 16:28931965-28939342 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell Follicular B cell Regulatory plasma cell cancer cell follicular cell plasmablast memory B cell fibroblast Other: Adaptive Immune System Innate Immune System Intracellular signaling by second messengers CD28 Gene Information Basic Information Ensembl ID: ENSG00000178562 Description: CD28 molecule [Source:HGNC Symbol;Acc:HGNC:1653] Location: 2:203706517-203739756 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell developing T cell Regulatory T cell CD8+ T cell CD4+ T cell T cell Specialized T cell Other: Adaptive Immune System Intracellular signaling by second messengers PI3K/AKT Signaling in Cancer CD80 Gene Information Basic Information Ensembl ID: ENSG00000121594 Description: CD80 molecule [Source:HGNC Symbol;Acc:HGNC:1700] Location: 3:119524293-119559614 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell Other: Cytokine Signaling in Immune system Adaptive Immune System Intracellular signaling by second messengers CD86 Gene Information Basic Information Ensembl ID: ENSG00000114013 Description: CD86 molecule [Source:HGNC Symbol;Acc:HGNC:1705] Location: 3:122055362-122121139 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell macrophage phagocyte monocyte immune cell Other: Cytokine Signaling in Immune system Adaptive Immune System Intracellular signaling by second messengers CDKN1A Gene Information Basic Information Ensembl ID: ENSG00000124762 Description: cyclin dependent kinase inhibitor 1A [Source:HGNC Symbol;Acc:HGNC:1784] Location: 6:36676460-36687397 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell pericyte dendritic cell smooth muscle cell fibroblast muscle cell monocyte Other: Cytokine Signaling in Immune system Cellular responses to stress Post-translational protein modification CHUK Gene Information Basic Information Ensembl ID: ENSG00000213341 Description: component of inhibitor of nuclear factor kappa B kinase complex [Source:HGNC Symbol;Acc:HGNC:1974] Location: 10:100188300-100229596 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Intracellular signaling by second messengers Cytokine Signaling in Immune system Adaptive Immune System EGF Gene Information Basic Information Ensembl ID: ENSG00000138798 Description: epidermal growth factor [Source:HGNC Symbol;Acc:HGNC:3229] Location: 4:109912883-110013766 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: skeletal muscle cell epithelial cell glial cell Other: Signaling by NOTCH Membrane Trafficking Cellular responses to stress EGFR Gene Information Basic Information Ensembl ID: ENSG00000146648 Description: epidermal growth factor receptor [Source:HGNC Symbol;Acc:HGNC:3236] Location: 7:55019017-55211628 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell endothelial cell trophoblast cell hepatocyte stem cell adipocyte fibroblast muscle cell stromal cell mesenchymal stem cell skeletal muscle cell cancer cell Other: Signaling by NOTCH Membrane Trafficking Signaling by GPCR ERBB3 Gene Information Basic Information Ensembl ID: ENSG00000065361 Description: erb-b2 receptor tyrosine kinase 3 [Source:HGNC Symbol;Acc:HGNC:3431] Location: 12:56076799-56103505 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron glial cell schwann cell neural crest cell progenitor cell Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Non-Receptor Tyrosine Kinases ESR1 Gene Information Basic Information Ensembl ID: ENSG00000091831 Description: estrogen receptor 1 [Source:HGNC Symbol;Acc:HGNC:3467] Location: 6:151656691-152129619 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: fibroblast stromal cell plasma cell Other: Cellular responses to stress Post-translational protein modification RNA Polymerase II Transcription EZH2 Gene Information Basic Information Ensembl ID: ENSG00000106462 Description: enhancer of zeste 2 polycomb repressive complex 2 subunit [Source:HGNC Symbol;Acc:HGNC:3527] Location: 7:148807257-148884321 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell Other: Epigenetic regulation of gene expression Cellular responses to stress Chromatin modifying enzymes FGF18 Gene Information Basic Information Ensembl ID: ENSG00000156427 Description: fibroblast growth factor 18 [Source:HGNC Symbol;Acc:HGNC:3674] Location: 5:171419647-171457626 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases FGF2 Gene Information Basic Information Ensembl ID: ENSG00000138685 Description: fibroblast growth factor 2 [Source:HGNC Symbol;Acc:HGNC:3676] Location: 4:122826682-122898236 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: fibroblast glial cell adipocyte Other: Non-integrin membrane-ECM interactions Cytokine Signaling in Immune system Transcriptional regulation of pluripotent stem cells FGFR1 Gene Information Basic Information Ensembl ID: ENSG00000077782 Description: fibroblast growth factor receptor 1 [Source:HGNC Symbol;Acc:HGNC:3688] Location: 8:38400215-38468834 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell fibroblast epithelial cell stem cell stromal cell Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases FGFR3 Gene Information Basic Information Ensembl ID: ENSG00000068078 Description: fibroblast growth factor receptor 3 [Source:HGNC Symbol;Acc:HGNC:3690] Location: 4:1793293-1808872 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stem cell astrocyte epithelial cell Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases FLT3 Gene Information Basic Information Ensembl ID: ENSG00000122025 Description: fms related receptor tyrosine kinase 3 [Source:HGNC Symbol;Acc:HGNC:3765] Location: 13:28003274-28100592 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell Other: MAPK family signaling cascades Cytokine Signaling in Immune system Intracellular signaling by second messengers FYN Gene Information Basic Information Ensembl ID: ENSG00000010810 Description: FYN proto-oncogene%2C Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:4037] Location: 6:111660332-111873452 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Cellular responses to mechanical stimuli HDAC3 Gene Information Basic Information Ensembl ID: ENSG00000171720 Description: histone deacetylase 3 [Source:HGNC Symbol;Acc:HGNC:4854] Location: 5:141620876-141636849 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Death Receptor Signaling Signaling by NOTCH Mitochondrial biogenesis HGF Gene Information Basic Information Ensembl ID: ENSG00000019991 Description: hepatocyte growth factor [Source:HGNC Symbol;Acc:HGNC:4893] Location: 7:81699010-81770438 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stellate cell fibroblast stromal cell bone cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades Platelet activation, signaling and aggregation ICOS Gene Information Basic Information Ensembl ID: ENSG00000163600 Description: inducible T cell costimulator [Source:HGNC Symbol;Acc:HGNC:5351] Location: 2:203936763-203961577 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: developing T cell Regulatory T cell CD4+ T cell memory T cell T helper cell T cell Other: Adaptive Immune System Intracellular signaling by second messengers PI3K/AKT Signaling in Cancer IL1RAP Gene Information Basic Information Ensembl ID: ENSG00000196083 Description: interleukin 1 receptor accessory protein [Source:HGNC Symbol;Acc:HGNC:5995] Location: 3:190514051-190659750 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell hepatocyte sensory neuron neuron granulocyte cancer stem cell Other: Cytokine Signaling in Immune system Protein-protein interactions at synapses Intracellular signaling by second messengers IL1RL1 Gene Information Basic Information Ensembl ID: ENSG00000115602 Description: interleukin 1 receptor like 1 [Source:HGNC Symbol;Acc:HGNC:5998] Location: 2:102311502-102352037 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell endothelial cell mast cell lymphocyte Other: Cytokine Signaling in Immune system Intracellular signaling by second messengers IRAK1 Gene Information Basic Information Ensembl ID: ENSG00000184216 Description: interleukin 1 receptor associated kinase 1 [Source:HGNC Symbol;Acc:HGNC:6112] Location: X:154010506-154019902 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: monocyte Other: Cytokine Signaling in Immune system Innate Immune System RNA Polymerase II Transcription IRAK4 Gene Information Basic Information Ensembl ID: ENSG00000198001 Description: interleukin 1 receptor associated kinase 4 [Source:HGNC Symbol;Acc:HGNC:17967] Location: 12:43758944-43798307 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Innate Immune System Intracellular signaling by second messengers IRS1 Gene Information Basic Information Ensembl ID: ENSG00000169047 Description: insulin receptor substrate 1 [Source:HGNC Symbol;Acc:HGNC:6125] Location: 2:226731312-226799820 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Signaling by Leptin MAPK family signaling cascades KIT Gene Information Basic Information Ensembl ID: ENSG00000157404 Description: KIT proto-oncogene%2C receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6342] Location: 4:54657267-54740783 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell intercalated cell tuft cell brush cell mast cell progenitor cell stem cell melanocyte Specialized T cell hematopoietic progenitor cell hematopoietic cell cancer stem cell stromal cell interstitial cell Other: MAPK family signaling cascades RNA Polymerase II Transcription Intracellular signaling by second messengers LCK Gene Information Basic Information Ensembl ID: ENSG00000182866 Description: LCK proto-oncogene%2C Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6524] Location: 1:32251244-32286165 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell CD8+ T cell developing T cell T cell lymphocyte Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System MAPK1 Gene Information Basic Information Ensembl ID: ENSG00000100030 Description: mitogen-activated protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:6871] Location: 22:21759657-21867680 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Transmission across Chemical Synapses Signaling by NODAL MAPK3 Gene Information Basic Information Ensembl ID: ENSG00000102882 Description: mitogen-activated protein kinase 3 [Source:HGNC Symbol;Acc:HGNC:6877] Location: 16:30114105-30123506 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Transmission across Chemical Synapses Signaling by NODAL MET Gene Information Basic Information Ensembl ID: ENSG00000105976 Description: MET proto-oncogene%2C receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:7029] Location: 7:116672196-116798377 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell pancreatic cell melanocyte Other: MAPK family signaling cascades RNA Polymerase II Transcription Intracellular signaling by second messengers MTOR Gene Information Basic Information Ensembl ID: ENSG00000198793 Description: mechanistic target of rapamycin kinase [Source:HGNC Symbol;Acc:HGNC:3942] Location: 1:11106535-11262556 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Adaptive Immune System Macroautophagy MTOR signalling MYD88 Gene Information Basic Information Ensembl ID: ENSG00000172936 Description: MYD88 innate immune signal transduction adaptor [Source:HGNC Symbol;Acc:HGNC:7562] Location: 3:38138552-38143024 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: monocyte Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System NR4A1 Gene Information Basic Information Ensembl ID: ENSG00000123358 Description: nuclear receptor subfamily 4 group A member 1 [Source:HGNC Symbol;Acc:HGNC:7980] Location: 12:52022832-52059507 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: RNA Polymerase II Transcription Intracellular signaling by second messengers PI3K/AKT Signaling in Cancer PDGFA Gene Information Basic Information Ensembl ID: ENSG00000197461 Description: platelet derived growth factor subunit A [Source:HGNC Symbol;Acc:HGNC:8799] Location: 7:497258-520296 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte smooth muscle cell Specialized T cell secretory cell Other: Cellular responses to stress Non-integrin membrane-ECM interactions MAPK family signaling cascades PDGFB Gene Information Basic Information Ensembl ID: ENSG00000100311 Description: platelet derived growth factor subunit B [Source:HGNC Symbol;Acc:HGNC:8800] Location: 22:39223359-39244982 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell Other: Non-integrin membrane-ECM interactions MAPK family signaling cascades Platelet activation, signaling and aggregation PDGFRA Gene Information Basic Information Ensembl ID: ENSG00000134853 Description: platelet derived growth factor receptor alpha [Source:HGNC Symbol;Acc:HGNC:8803] Location: 4:54229280-54298245 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: fibroblast pericyte stellate cell stem cell embryonic cell stromal cell smooth muscle cell oligodendrocyte precursor cell epithelial cell oligodendrocyte progenitor cell mesodermal cell valve interstitial cell Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases PDGFRB Gene Information Basic Information Ensembl ID: ENSG00000113721 Description: platelet derived growth factor receptor beta [Source:HGNC Symbol;Acc:HGNC:8804] Location: 5:150113839-150155872 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: smooth muscle cell stellate cell endothelial cell pericyte fibroblast stromal cell mural cell adipocyte neuron mesenchymal cell vascular cell Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases PIK3CA Gene Information Basic Information Ensembl ID: ENSG00000121879 Description: phosphatidylinositol-4%2C5-bisphosphate 3-kinase catalytic subunit alpha [Source:HGNC Symbol;Acc:HGNC:8975] Location: 3:179148114-179240093 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System PIK3CD Gene Information Basic Information Ensembl ID: ENSG00000171608 Description: phosphatidylinositol-4%2C5-bisphosphate 3-kinase catalytic subunit delta [Source:HGNC Symbol;Acc:HGNC:8977] Location: 1:9629889-9729114 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: developing T cell T cell hematopoietic cell Other: Cytokine Signaling in Immune system Adaptive Immune System Metabolism of lipids PIK3CG Gene Information Basic Information Ensembl ID: ENSG00000105851 Description: phosphatidylinositol-4%2C5-bisphosphate 3-kinase catalytic subunit gamma [Source:HGNC Symbol;Acc:HGNC:8978] Location: 7:106865278-106908980 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: tuft cell Other: Adaptive Immune System Signaling by GPCR Metabolism of lipids PPARG Gene Information Basic Information Ensembl ID: ENSG00000132170 Description: peroxisome proliferator activated receptor gamma [Source:HGNC Symbol;Acc:HGNC:9236] Location: 3:12287368-12434356 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell pericyte epithelial cell stem cell phagocyte adipocyte macrophage tuft cell Other: Epigenetic regulation of gene expression Metabolism of lipids Post-translational protein modification PRKCA Gene Information Basic Information Ensembl ID: ENSG00000154229 Description: protein kinase C alpha [Source:HGNC Symbol;Acc:HGNC:9393] Location: 17:66302613-66810743 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: bipolar cell Other: Transmission across Chemical Synapses Integration of energy metabolism Signaling by WNT PTPN11 Gene Information Basic Information Ensembl ID: ENSG00000179295 Description: protein tyrosine phosphatase non-receptor type 11 [Source:HGNC Symbol;Acc:HGNC:9644] Location: 12:112418351-112509918 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System TP53 Gene Information Basic Information Ensembl ID: ENSG00000141510 Description: tumor protein p53 [Source:HGNC Symbol;Acc:HGNC:11998] Location: 17:7661779-7687546 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Cytokine Signaling in Immune system Signaling by NOTCH TRAT1 Gene Information Basic Information Ensembl ID: ENSG00000163519 Description: T cell receptor associated transmembrane adaptor 1 [Source:HGNC Symbol;Acc:HGNC:30698] Location: 3:108822770-108855005 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell CD8+ T cell developing T cell T cell Specialized T cell CD4+ T cell Other: Adaptive Immune System Intracellular signaling by second messengers PI3K/AKT Signaling in Cancer
Kidney development Pathway Hierarchies & Genes Formation of the nephric duct (4 genes) Developmental Biology Kidney development Formation of the nephric duct 4 genes Formation of the ureteric bud (2 genes) Developmental Biology Kidney development Formation of the ureteric bud 2 genes Nephron development (2 genes) Developmental Biology Kidney development Nephron development 2 genes	CTNNB1 Gene Information Basic Information Ensembl ID: ENSG00000168036 Description: catenin beta 1 [Source:HGNC Symbol;Acc:HGNC:2514] Location: 3:41194741-41260096 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell endothelial cell epithelial cell stem cell phagocyte adrenal cortical cell fibroblast monocyte Specialized T cell melanocyte M cell Other: Apoptosis Innate Immune System Signaling by WNT FGF2 Gene Information Basic Information Ensembl ID: ENSG00000138685 Description: fibroblast growth factor 2 [Source:HGNC Symbol;Acc:HGNC:3676] Location: 4:122826682-122898236 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: fibroblast glial cell adipocyte Other: Non-integrin membrane-ECM interactions Cytokine Signaling in Immune system Transcriptional regulation of pluripotent stem cells GATA3 Gene Information Basic Information Ensembl ID: ENSG00000107485 Description: GATA binding protein 3 [Source:HGNC Symbol;Acc:HGNC:4172] Location: 10:8045378-8075198 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell epithelial cell trophoblast cell developing T cell Regulatory T cell phagocyte natural killer cell CD4+ T cell lymphocyte innate lymphoid cell T helper cell neuron Other: Cytokine Signaling in Immune system Post-translational protein modification RNA Polymerase II Transcription ID4 Gene Information Basic Information Ensembl ID: ENSG00000172201 Description: inhibitor of DNA binding 4 [Source:HGNC Symbol;Acc:HGNC:5363] Location: 6:19837370-19842197 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte epithelial cell progenitor cell stem cell glial cell stromal cell smooth muscle cell fibroblast muscle cell astrocyte Other: Signaling by Receptor Tyrosine Kinases Kidney development ITGB1 Gene Information Basic Information Ensembl ID: ENSG00000150093 Description: integrin subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:6153] Location: 10:32887273-33005792 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stellate cell pericyte trophoblast cell epithelial cell stromal cell stem cell endothelial cell smooth muscle cell fibroblast mesenchymal stem cell Other: Laminin interactions Cell surface interactions at the vascular wall Cytokine Signaling in Immune system JAG1 Gene Information Basic Information Ensembl ID: ENSG00000101384 Description: jagged canonical Notch ligand 1 [Source:HGNC Symbol;Acc:HGNC:6188] Location: 20:10637684-10673999 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell pericyte smooth muscle cell mural cell Other: Signaling by NOTCH RNA Polymerase II Transcription Signaling by Rho GTPases, Miro GTPases and RHOBTB3 WNT11 Gene Information Basic Information Ensembl ID: ENSG00000085741 Description: Wnt family member 11 [Source:HGNC Symbol;Acc:HGNC:12776] Location: 11:76186325-76210736 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Signaling by WNT Signaling by GPCR Kidney development WT1 Gene Information Basic Information Ensembl ID: ENSG00000184937 Description: WT1 transcription factor [Source:HGNC Symbol;Acc:HGNC:12796] Location: 11:32387775-32435564 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell stromal cell podocyte mesothelial cell Other: Cell junction organization Transcriptional regulation of testis differentiation Kidney development
Laminin interactions Pathway Hierarchies & Genes Laminin interactions (8 genes) Extracellular matrix organization Laminin interactions 8 genes	ITGA1 Gene Information Basic Information Ensembl ID: ENSG00000213949 Description: integrin subunit alpha 1 [Source:HGNC Symbol;Acc:HGNC:6134] Location: 5:52787916-52959209 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell pericyte developing T cell epithelial cell fibroblast glial cell stromal cell Specialized T cell smooth muscle cell CD8+ T cell T cell mesenchymal cell lymphocyte beta cell memory T cell Other: Integrin cell surface interactions Laminin interactions Smooth Muscle Contraction ITGA2 Gene Information Basic Information Ensembl ID: ENSG00000164171 Description: integrin subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:6137] Location: 5:52989340-53094779 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell stem cell pancreatic cell goblet cell Other: Integrin cell surface interactions Laminin interactions Non-integrin membrane-ECM interactions ITGA6 Gene Information Basic Information Ensembl ID: ENSG00000091409 Description: integrin subunit alpha 6 [Source:HGNC Symbol;Acc:HGNC:6142] Location: 2:172234216-172506459 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell goblet cell kidney cell pericyte epithelial cell embryonic cell stem cell glial cell stromal cell Other: Collagen formation Cell surface interactions at the vascular wall Integrin cell surface interactions ITGAV Gene Information Basic Information Ensembl ID: ENSG00000138448 Description: integrin subunit alpha V [Source:HGNC Symbol;Acc:HGNC:6150] Location: 2:186590010-186680901 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell glial cell stromal cell M cell endothelial cell Other: Adaptive Immune System Elastic fibre formation Innate Immune System ITGB1 Gene Information Basic Information Ensembl ID: ENSG00000150093 Description: integrin subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:6153] Location: 10:32887273-33005792 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stellate cell pericyte trophoblast cell epithelial cell stromal cell stem cell endothelial cell smooth muscle cell fibroblast mesenchymal stem cell Other: Laminin interactions Cell surface interactions at the vascular wall Cytokine Signaling in Immune system ITGB4 Gene Information Basic Information Ensembl ID: ENSG00000132470 Description: integrin subunit beta 4 [Source:HGNC Symbol;Acc:HGNC:6158] Location: 17:75721328-75757818 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron epithelial cell schwann cell astrocyte dendritic cell M cell endothelial cell Other: Collagen formation Laminin interactions Non-integrin membrane-ECM interactions LAMB3 Gene Information Basic Information Ensembl ID: ENSG00000196878 Description: laminin subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:6490] Location: 1:209614870-209652425 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell stem cell pancreatic cell goblet cell M cell Other: Degradation of the extracellular matrix Collagen formation Laminin interactions LAMC2 Gene Information Basic Information Ensembl ID: ENSG00000058085 Description: laminin subunit gamma 2 [Source:HGNC Symbol;Acc:HGNC:6493] Location: 1:183186238-183245127 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell pancreatic cell goblet cell M cell stem cell Other: Degradation of the extracellular matrix Collagen formation Laminin interactions
Late endosomal microautophagy Pathway Hierarchies & Genes Late endosomal microautophagy (1 genes) Autophagy Late endosomal microautophagy 1 genes	VIM Gene Information Basic Information Ensembl ID: ENSG00000026025 Description: vimentin [Source:HGNC Symbol;Acc:HGNC:12692] Location: 10:17228241-17237593 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell pericyte macrophage monocyte stem cell embryonic cell phagocyte fibroblast glial cell smooth muscle cell oligodendrocyte precursor cell bone cell mast cell granulocyte antigen presenting cell interstitial cell mesenchymal cell mesenchymal stem cell Other: Apoptosis Cytokine Signaling in Immune system Macroautophagy
MAPK family signaling cascades Pathway Hierarchies & Genes Negative feedback regulation of MAPK pathway (3 genes) Signal Transduction MAPK family signaling cascades MAPK1/MAPK3 signaling RAF/MAP kinase cascade Negative regulation of MAPK pathway Negative feedback regulation of MAPK pathway 3 genes MAP2K and MAPK activation (2 genes) Signal Transduction MAPK family signaling cascades MAPK1/MAPK3 signaling RAF/MAP kinase cascade MAP2K and MAPK activation 2 genes MAPK3 (ERK1) activation (6 genes) Signal Transduction MAPK family signaling cascades MAPK1/MAPK3 signaling RAF-independent MAPK1/3 activation MAPK3 (ERK1) activation 6 genes Negative regulation of MAPK pathway (3 genes) Signal Transduction MAPK family signaling cascades MAPK1/MAPK3 signaling RAF/MAP kinase cascade Negative regulation of MAPK pathway 3 genes RAS processing (1 genes) Signal Transduction MAPK family signaling cascades MAPK1/MAPK3 signaling RAF/MAP kinase cascade RAS processing 1 genes Regulation of RAS by GAPs (4 genes) Signal Transduction MAPK family signaling cascades MAPK1/MAPK3 signaling RAF/MAP kinase cascade Regulation of RAS by GAPs 4 genes RAF/MAP kinase cascade (31 genes) Signal Transduction MAPK family signaling cascades MAPK1/MAPK3 signaling RAF/MAP kinase cascade 31 genes MAPK6/MAPK4 signaling (3 genes) Signal Transduction MAPK family signaling cascades MAPK6/MAPK4 signaling 3 genes	ANGPT1 Gene Information Basic Information Ensembl ID: ENSG00000154188 Description: angiopoietin 1 [Source:HGNC Symbol;Acc:HGNC:484] Location: 8:107249482-107498055 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: fibroblast pericyte stromal cell smooth muscle cell epithelial cell megakaryocyte Other: MAPK family signaling cascades Cell surface interactions at the vascular wall BCL2L1 Gene Information Basic Information Ensembl ID: ENSG00000171552 Description: BCL2 like 1 [Source:HGNC Symbol;Acc:HGNC:992] Location: 20:31664452-31723989 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System CCND3 Gene Information Basic Information Ensembl ID: ENSG00000112576 Description: cyclin D3 [Source:HGNC Symbol;Acc:HGNC:1585] Location: 6:41934934-42050357 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell natural killer cell developing T cell epithelial cell CD4+ T cell lymphoid progenitor cell T cell hematopoietic cell Specialized T cell memory T cell lymphocyte megakaryocyte Other: MAPK family signaling cascades Cell Cycle, Mitotic RNA Polymerase II Transcription CSF2 Gene Information Basic Information Ensembl ID: ENSG00000164400 Description: colony stimulating factor 2 [Source:HGNC Symbol;Acc:HGNC:2434] Location: 5:132073789-132076170 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system MAPK family signaling cascades RNA Polymerase II Transcription CSF2RA Gene Information Basic Information Ensembl ID: ENSG00000198223 Description: colony stimulating factor 2 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:2435] Location: X:1268793-1325373 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron dendritic cell macrophage phagocyte microglia monocyte antigen presenting cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades Surfactant metabolism CSF2RB Gene Information Basic Information Ensembl ID: ENSG00000100368 Description: colony stimulating factor 2 receptor subunit beta [Source:HGNC Symbol;Acc:HGNC:2436] Location: 22:36913628-36940439 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell dendritic cell mast cell antigen presenting cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades Surfactant metabolism DUSP2 Gene Information Basic Information Ensembl ID: ENSG00000158050 Description: dual specificity phosphatase 2 [Source:HGNC Symbol;Acc:HGNC:3068] Location: 2:96143166-96145440 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell CD8+ T cell memory T cell developing T cell T cell phagocyte Specialized T cell leukocyte CD4+ T cell monocyte Other: MAPK family signaling cascades DUSP4 Gene Information Basic Information Ensembl ID: ENSG00000120875 Description: dual specificity phosphatase 4 [Source:HGNC Symbol;Acc:HGNC:3070] Location: 8:29333064-29350684 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell developing T cell Regulatory T cell Specialized T cell autonomic neuron Other: Cytokine Signaling in Immune system Innate Immune System MAPK family signaling cascades DUSP6 Gene Information Basic Information Ensembl ID: ENSG00000139318 Description: dual specificity phosphatase 6 [Source:HGNC Symbol;Acc:HGNC:3072] Location: 12:89347235-89352501 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell endothelial cell phagocyte mast cell monocyte granulocyte myeloid cell innate lymphoid cell Other: Cytokine Signaling in Immune system Innate Immune System MAPK family signaling cascades EGF Gene Information Basic Information Ensembl ID: ENSG00000138798 Description: epidermal growth factor [Source:HGNC Symbol;Acc:HGNC:3229] Location: 4:109912883-110013766 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: skeletal muscle cell epithelial cell glial cell Other: Signaling by NOTCH Membrane Trafficking Cellular responses to stress EGFR Gene Information Basic Information Ensembl ID: ENSG00000146648 Description: epidermal growth factor receptor [Source:HGNC Symbol;Acc:HGNC:3236] Location: 7:55019017-55211628 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell endothelial cell trophoblast cell hepatocyte stem cell adipocyte fibroblast muscle cell stromal cell mesenchymal stem cell skeletal muscle cell cancer cell Other: Signaling by NOTCH Membrane Trafficking Signaling by GPCR ERBB3 Gene Information Basic Information Ensembl ID: ENSG00000065361 Description: erb-b2 receptor tyrosine kinase 3 [Source:HGNC Symbol;Acc:HGNC:3431] Location: 12:56076799-56103505 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron glial cell schwann cell neural crest cell progenitor cell Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Non-Receptor Tyrosine Kinases FGF18 Gene Information Basic Information Ensembl ID: ENSG00000156427 Description: fibroblast growth factor 18 [Source:HGNC Symbol;Acc:HGNC:3674] Location: 5:171419647-171457626 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases FGF2 Gene Information Basic Information Ensembl ID: ENSG00000138685 Description: fibroblast growth factor 2 [Source:HGNC Symbol;Acc:HGNC:3676] Location: 4:122826682-122898236 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: fibroblast glial cell adipocyte Other: Non-integrin membrane-ECM interactions Cytokine Signaling in Immune system Transcriptional regulation of pluripotent stem cells FGFR1 Gene Information Basic Information Ensembl ID: ENSG00000077782 Description: fibroblast growth factor receptor 1 [Source:HGNC Symbol;Acc:HGNC:3688] Location: 8:38400215-38468834 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell fibroblast epithelial cell stem cell stromal cell Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases FGFR3 Gene Information Basic Information Ensembl ID: ENSG00000068078 Description: fibroblast growth factor receptor 3 [Source:HGNC Symbol;Acc:HGNC:3690] Location: 4:1793293-1808872 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stem cell astrocyte epithelial cell Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases FLT3 Gene Information Basic Information Ensembl ID: ENSG00000122025 Description: fms related receptor tyrosine kinase 3 [Source:HGNC Symbol;Acc:HGNC:3765] Location: 13:28003274-28100592 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell Other: MAPK family signaling cascades Cytokine Signaling in Immune system Intracellular signaling by second messengers FN1 Gene Information Basic Information Ensembl ID: ENSG00000115414 Description: fibronectin 1 [Source:HGNC Symbol;Acc:HGNC:3778] Location: 2:215360440-215436073 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell fibroblast endocrine cell pericyte epithelial cell stellate cell stem cell phagocyte muscle cell stromal cell smooth muscle cell thymic epithelial cell skeletal muscle cell mesenchymal cell Other: Cytokine Signaling in Immune system Degradation of the extracellular matrix Elastic fibre formation FYN Gene Information Basic Information Ensembl ID: ENSG00000010810 Description: FYN proto-oncogene%2C Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:4037] Location: 6:111660332-111873452 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Cellular responses to mechanical stimuli HGF Gene Information Basic Information Ensembl ID: ENSG00000019991 Description: hepatocyte growth factor [Source:HGNC Symbol;Acc:HGNC:4893] Location: 7:81699010-81770438 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stellate cell fibroblast stromal cell bone cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades Platelet activation, signaling and aggregation HRAS Gene Information Basic Information Ensembl ID: ENSG00000174775 Description: HRas proto-oncogene%2C GTPase [Source:HGNC Symbol;Acc:HGNC:5173] Location: 11:532242-537321 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Transmission across Chemical Synapses Cytokine Signaling in Immune system Adaptive Immune System IL2 Gene Information Basic Information Ensembl ID: ENSG00000109471 Description: interleukin 2 [Source:HGNC Symbol;Acc:HGNC:6001] Location: 4:122451470-122456725 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: CD4+ T cell innate lymphoid cell CD8+ T cell developing T cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades RNA Polymerase II Transcription IL2RA Gene Information Basic Information Ensembl ID: ENSG00000134460 Description: interleukin 2 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:6008] Location: 10:6010689-6062370 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Regulatory T cell macrophage dendritic cell developing T cell B cell mast cell CD8+ T cell T cell Follicular B cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades RNA Polymerase II Transcription IL2RB Gene Information Basic Information Ensembl ID: ENSG00000100385 Description: interleukin 2 receptor subunit beta [Source:HGNC Symbol;Acc:HGNC:6009] Location: 22:37118666-37175118 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell developing T cell T cell Specialized T cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades IL2RG Gene Information Basic Information Ensembl ID: ENSG00000147168 Description: interleukin 2 receptor subunit gamma [Source:HGNC Symbol;Acc:HGNC:6010] Location: X:71107404-71112108 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell CD8+ T cell developing T cell T cell Regulatory T cell leukocyte Specialized T cell lymphocyte Other: Cytokine Signaling in Immune system MAPK family signaling cascades Signaling by Receptor Tyrosine Kinases IL3RA Gene Information Basic Information Ensembl ID: ENSG00000185291 Description: interleukin 3 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:6012] Location: X:1336616-1382689 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell enteroendocrine cell endothelial cell dendritic cell progenitor bone cell basophil antigen presenting cell plasma cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades IL5RA Gene Information Basic Information Ensembl ID: ENSG00000091181 Description: interleukin 5 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:6017] Location: 3:3066324-3126613 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: mast cell eosinophil Other: Cytokine Signaling in Immune system MAPK family signaling cascades IL6 Gene Information Basic Information Ensembl ID: ENSG00000136244 Description: interleukin 6 [Source:HGNC Symbol;Acc:HGNC:6018] Location: 7:22725884-22732002 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte endothelial cell stromal cell smooth muscle cell CD4+ T cell vascular cell immune cell Other: Cytokine Signaling in Immune system Cellular responses to stress Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) IL6R Gene Information Basic Information Ensembl ID: ENSG00000160712 Description: interleukin 6 receptor [Source:HGNC Symbol;Acc:HGNC:6019] Location: 1:154405193-154469450 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: CD4+ T cell neutrophil Other: Cytokine Signaling in Immune system MAPK family signaling cascades Transcriptional regulation of granulopoiesis IL6ST Gene Information Basic Information Ensembl ID: ENSG00000134352 Description: interleukin 6 cytokine family signal transducer [Source:HGNC Symbol;Acc:HGNC:6021] Location: 5:55935095-55995022 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell stromal cell pericyte stem cell fibroblast epithelial cell interstitial cell developing T cell mesenchymal stem cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades IRS1 Gene Information Basic Information Ensembl ID: ENSG00000169047 Description: insulin receptor substrate 1 [Source:HGNC Symbol;Acc:HGNC:6125] Location: 2:226731312-226799820 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Signaling by Leptin MAPK family signaling cascades ITGB3 Gene Information Basic Information Ensembl ID: ENSG00000259207 Description: integrin subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:6156] Location: 17:47253827-47313743 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: platelet epithelial cell monocyte Other: ECM proteoglycans Elastic fibre formation Cell surface interactions at the vascular wall JAK2 Gene Information Basic Information Ensembl ID: ENSG00000096968 Description: Janus kinase 2 [Source:HGNC Symbol;Acc:HGNC:6192] Location: 9:4984390-5129948 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: fibroblast basophil dendritic cell Other: Chromatin modifying enzymes Cytokine Signaling in Immune system Signaling by Leptin JAK3 Gene Information Basic Information Ensembl ID: ENSG00000105639 Description: Janus kinase 3 [Source:HGNC Symbol;Acc:HGNC:6193] Location: 19:17824780-17848071 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Specialized T cell CD4+ T cell T cell CD8+ T cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades Signaling by Receptor Tyrosine Kinases KIT Gene Information Basic Information Ensembl ID: ENSG00000157404 Description: KIT proto-oncogene%2C receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6342] Location: 4:54657267-54740783 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell intercalated cell tuft cell brush cell mast cell progenitor cell stem cell melanocyte Specialized T cell hematopoietic progenitor cell hematopoietic cell cancer stem cell stromal cell interstitial cell Other: MAPK family signaling cascades RNA Polymerase II Transcription Intracellular signaling by second messengers KRAS Gene Information Basic Information Ensembl ID: ENSG00000133703 Description: KRAS proto-oncogene%2C GTPase [Source:HGNC Symbol;Acc:HGNC:6407] Location: 12:25205246-25250936 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Signaling by Non-Receptor Tyrosine Kinases Transmission across Chemical Synapses Cytokine Signaling in Immune system MAP2K1 Gene Information Basic Information Ensembl ID: ENSG00000169032 Description: mitogen-activated protein kinase kinase 1 [Source:HGNC Symbol;Acc:HGNC:6840] Location: 15:66386837-66491656 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Innate Immune System MAPK family signaling cascades MAPK1 Gene Information Basic Information Ensembl ID: ENSG00000100030 Description: mitogen-activated protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:6871] Location: 22:21759657-21867680 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Transmission across Chemical Synapses Signaling by NODAL MAPK3 Gene Information Basic Information Ensembl ID: ENSG00000102882 Description: mitogen-activated protein kinase 3 [Source:HGNC Symbol;Acc:HGNC:6877] Location: 16:30114105-30123506 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Transmission across Chemical Synapses Signaling by NODAL MET Gene Information Basic Information Ensembl ID: ENSG00000105976 Description: MET proto-oncogene%2C receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:7029] Location: 7:116672196-116798377 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell pancreatic cell melanocyte Other: MAPK family signaling cascades RNA Polymerase II Transcription Intracellular signaling by second messengers MMP2 Gene Information Basic Information Ensembl ID: ENSG00000087245 Description: matrix metallopeptidase 2 [Source:HGNC Symbol;Acc:HGNC:7166] Location: 16:55389700-55506691 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: mesenchymal cell smooth muscle cell Other: Cytokine Signaling in Immune system Degradation of the extracellular matrix Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MYC Gene Information Basic Information Ensembl ID: ENSG00000136997 Description: MYC proto-oncogene%2C bHLH transcription factor [Source:HGNC Symbol;Acc:HGNC:7553] Location: 8:127735434-127742951 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte epithelial cell fibroblast stromal cell smooth muscle cell hematopoietic progenitor cell endothelial cell stem cell erythroblast muscle cell progenitor cell transient amplifying cell cancer stem cell B cell erythroid lineage cell Other: Cytokine Signaling in Immune system Signaling by NOTCH Signaling by WNT NCAM1 Gene Information Basic Information Ensembl ID: ENSG00000149294 Description: neural cell adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:7656] Location: 11:112961275-113278436 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron natural killer cell interneuron pericyte T cell glial cell smooth muscle cell motor neuron Specialized T cell innate lymphoid cell chromaffin cell epithelial cell neuroendocrine cell lymphocyte cancer stem cell progenitor cell stem cell mesenchymal stem cell immune cell cancer cell autonomic neuron Other: ECM proteoglycans Cytokine Signaling in Immune system MAPK family signaling cascades NF1 Gene Information Basic Information Ensembl ID: ENSG00000196712 Description: neurofibromin 1 [Source:HGNC Symbol;Acc:HGNC:7765] Location: 17:31094927-31382116 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell monocyte endothelial cell Other: MAPK family signaling cascades Oncogenic MAPK signaling NRAS Gene Information Basic Information Ensembl ID: ENSG00000213281 Description: NRAS proto-oncogene%2C GTPase [Source:HGNC Symbol;Acc:HGNC:7989] Location: 1:114704469-114716771 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell cancer cell Other: Signaling by Erythropoietin Signaling by Non-Receptor Tyrosine Kinases Signaling by Nuclear Receptors PDGFA Gene Information Basic Information Ensembl ID: ENSG00000197461 Description: platelet derived growth factor subunit A [Source:HGNC Symbol;Acc:HGNC:8799] Location: 7:497258-520296 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte smooth muscle cell Specialized T cell secretory cell Other: Cellular responses to stress Non-integrin membrane-ECM interactions MAPK family signaling cascades PDGFB Gene Information Basic Information Ensembl ID: ENSG00000100311 Description: platelet derived growth factor subunit B [Source:HGNC Symbol;Acc:HGNC:8800] Location: 22:39223359-39244982 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell Other: Non-integrin membrane-ECM interactions MAPK family signaling cascades Platelet activation, signaling and aggregation PDGFRA Gene Information Basic Information Ensembl ID: ENSG00000134853 Description: platelet derived growth factor receptor alpha [Source:HGNC Symbol;Acc:HGNC:8803] Location: 4:54229280-54298245 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: fibroblast pericyte stellate cell stem cell embryonic cell stromal cell smooth muscle cell oligodendrocyte precursor cell epithelial cell oligodendrocyte progenitor cell mesodermal cell valve interstitial cell Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases PDGFRB Gene Information Basic Information Ensembl ID: ENSG00000113721 Description: platelet derived growth factor receptor beta [Source:HGNC Symbol;Acc:HGNC:8804] Location: 5:150113839-150155872 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: smooth muscle cell stellate cell endothelial cell pericyte fibroblast stromal cell mural cell adipocyte neuron mesenchymal cell vascular cell Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases PIK3CA Gene Information Basic Information Ensembl ID: ENSG00000121879 Description: phosphatidylinositol-4%2C5-bisphosphate 3-kinase catalytic subunit alpha [Source:HGNC Symbol;Acc:HGNC:8975] Location: 3:179148114-179240093 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System PTPN11 Gene Information Basic Information Ensembl ID: ENSG00000179295 Description: protein tyrosine phosphatase non-receptor type 11 [Source:HGNC Symbol;Acc:HGNC:9644] Location: 12:112418351-112509918 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System TEK Gene Information Basic Information Ensembl ID: ENSG00000120156 Description: TEK receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:11724] Location: 9:27109141-27230174 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell Other: Cell surface interactions at the vascular wall MAPK family signaling cascades TYK2 Gene Information Basic Information Ensembl ID: ENSG00000105397 Description: tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:12440] Location: 19:10350528-10380608 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades Signaling by ALK in cancer
MITF-M-regulated melanocyte development Pathway Hierarchies & Genes Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition (10 genes) Developmental Biology MITF-M-regulated melanocyte development Transcriptional and post-translational regulation of MITF-M expression and activity 8 genes MITF-M-dependent gene expression Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition 2 genes Transcriptional and post-translational regulation of MITF-M expression and activity (6 genes) Developmental Biology MITF-M-regulated melanocyte development MITF-M-dependent gene expression Regulation of MITF-M-dependent genes involved in pigmentation 4 genes Transcriptional and post-translational regulation of MITF-M expression and activity 2 genes Regulation of MITF-M dependent genes involved in invasion (1 genes) Developmental Biology MITF-M-regulated melanocyte development MITF-M-dependent gene expression Regulation of MITF-M dependent genes involved in invasion 1 genes Regulation of MITF-M dependent genes involved in metabolism (1 genes) Developmental Biology MITF-M-regulated melanocyte development MITF-M-dependent gene expression Regulation of MITF-M dependent genes involved in metabolism 1 genes Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence (2 genes) Developmental Biology MITF-M-regulated melanocyte development MITF-M-dependent gene expression Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence 2 genes Regulation of MITF-M-dependent genes involved in apoptosis (1 genes) Developmental Biology MITF-M-regulated melanocyte development MITF-M-dependent gene expression Regulation of MITF-M-dependent genes involved in apoptosis 1 genes Regulation of MITF-M-dependent genes involved in cell cycle and proliferation (6 genes) Developmental Biology MITF-M-regulated melanocyte development MITF-M-dependent gene expression Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 6 genes Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition (1 genes) Developmental Biology MITF-M-regulated melanocyte development MITF-M-dependent gene expression Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition 1 genes	AKT2 Gene Information Basic Information Ensembl ID: ENSG00000105221 Description: AKT serine/threonine kinase 2 [Source:HGNC Symbol;Acc:HGNC:392] Location: 19:40230317-40285536 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: T cell Other: Apoptosis Cytokine Signaling in Immune system Adaptive Immune System AKT3 Gene Information Basic Information Ensembl ID: ENSG00000117020 Description: AKT serine/threonine kinase 3 [Source:HGNC Symbol;Acc:HGNC:393] Location: 1:243488233-243851079 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell neuron epithelial cell T cell fibroblast glial cell CD8+ T cell schwann cell Specialized T cell excitatory neuron smooth muscle cell Other: Apoptosis Cytokine Signaling in Immune system Adaptive Immune System BCL2 Gene Information Basic Information Ensembl ID: ENSG00000171791 Description: BCL2 apoptosis regulator [Source:HGNC Symbol;Acc:HGNC:990] Location: 18:63123346-63320128 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: cancer cell Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System BRCA1 Gene Information Basic Information Ensembl ID: ENSG00000012048 Description: BRCA1 DNA repair associated [Source:HGNC Symbol;Acc:HGNC:1100] Location: 17:43044295-43170245 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: cancer cell Other: Meiosis Cellular responses to stress DNA Double-Strand Break Repair CCNB1 Gene Information Basic Information Ensembl ID: ENSG00000134057 Description: cyclin B1 [Source:HGNC Symbol;Acc:HGNC:1579] Location: 5:69167135-69178245 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cell Cycle, Mitotic Cell Cycle Checkpoints RNA Polymerase II Transcription CCND1 Gene Information Basic Information Ensembl ID: ENSG00000110092 Description: cyclin D1 [Source:HGNC Symbol;Acc:HGNC:1582] Location: 11:69641156-69654474 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell endothelial cell pericyte monocyte fibroblast glial cell dendritic cell pancreatic cell M cell oligodendrocyte Other: Cytokine Signaling in Immune system Signaling by NOTCH Chromatin modifying enzymes CDH1 Gene Information Basic Information Ensembl ID: ENSG00000039068 Description: cadherin 1 [Source:HGNC Symbol;Acc:HGNC:1748] Location: 16:68737292-68835537 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: goblet cell epithelial cell pneumocyte stem cell secretory cell tuft cell paneth cell ciliated cell neuroendocrine cell brush cell basal cell serous cell deuterosomal cell club Other: Apoptosis Adaptive Immune System Degradation of the extracellular matrix CDK2 Gene Information Basic Information Ensembl ID: ENSG00000123374 Description: cyclin dependent kinase 2 [Source:HGNC Symbol;Acc:HGNC:1771] Location: 12:55966781-55972789 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Meiosis Cellular responses to stress DNA Double-Strand Break Repair CDKN1A Gene Information Basic Information Ensembl ID: ENSG00000124762 Description: cyclin dependent kinase inhibitor 1A [Source:HGNC Symbol;Acc:HGNC:1784] Location: 6:36676460-36687397 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell pericyte dendritic cell smooth muscle cell fibroblast muscle cell monocyte Other: Cytokine Signaling in Immune system Cellular responses to stress Post-translational protein modification CEACAM1 Gene Information Basic Information Ensembl ID: ENSG00000079385 Description: CEA cell adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:1814] Location: 19:42507304-42561234 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell epithelial cell stem cell myeloid cell secretory cell neutrophil trophoblast cell Other: Fibronectin matrix formation Innate Immune System Cell surface interactions at the vascular wall CREBBP Gene Information Basic Information Ensembl ID: ENSG00000005339 Description: CREB binding protein [Source:HGNC Symbol;Acc:HGNC:2348] Location: 16:3725054-3880713 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes BMAL1:CLOCK,NPAS2 activates circadian expression CSF1 Gene Information Basic Information Ensembl ID: ENSG00000184371 Description: colony stimulating factor 1 [Source:HGNC Symbol;Acc:HGNC:2432] Location: 1:109910242-109930992 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell stromal cell mast cell microglia Other: MITF-M-regulated melanocyte development Cytokine Signaling in Immune system Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) CTNNB1 Gene Information Basic Information Ensembl ID: ENSG00000168036 Description: catenin beta 1 [Source:HGNC Symbol;Acc:HGNC:2514] Location: 3:41194741-41260096 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell endothelial cell epithelial cell stem cell phagocyte adrenal cortical cell fibroblast monocyte Specialized T cell melanocyte M cell Other: Apoptosis Innate Immune System Signaling by WNT IRF4 Gene Information Basic Information Ensembl ID: ENSG00000137265 Description: interferon regulatory factor 4 [Source:HGNC Symbol;Acc:HGNC:6119] Location: 6:391739-411443 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell dendritic cell plasma cell antigen presenting cell lymphocyte plasmablast Other: Cytokine Signaling in Immune system MITF-M-regulated melanocyte development Signaling by ALK in cancer ITGA2 Gene Information Basic Information Ensembl ID: ENSG00000164171 Description: integrin subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:6137] Location: 5:52989340-53094779 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell stem cell pancreatic cell goblet cell Other: Integrin cell surface interactions Laminin interactions Non-integrin membrane-ECM interactions KIT Gene Information Basic Information Ensembl ID: ENSG00000157404 Description: KIT proto-oncogene%2C receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6342] Location: 4:54657267-54740783 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell intercalated cell tuft cell brush cell mast cell progenitor cell stem cell melanocyte Specialized T cell hematopoietic progenitor cell hematopoietic cell cancer stem cell stromal cell interstitial cell Other: MAPK family signaling cascades RNA Polymerase II Transcription Intracellular signaling by second messengers LEF1 Gene Information Basic Information Ensembl ID: ENSG00000138795 Description: lymphoid enhancer binding factor 1 [Source:HGNC Symbol;Acc:HGNC:6551] Location: 4:108047545-108168956 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell developing T cell T cell Regulatory T cell Naive B cell CD4+ T cell lymphoid progenitor cell innate lymphoid cell Other: Signaling by WNT RNA Polymerase II Transcription Transcriptional regulation of granulopoiesis MAPK1 Gene Information Basic Information Ensembl ID: ENSG00000100030 Description: mitogen-activated protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:6871] Location: 22:21759657-21867680 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Transmission across Chemical Synapses Signaling by NODAL MAPK14 Gene Information Basic Information Ensembl ID: ENSG00000112062 Description: mitogen-activated protein kinase 14 [Source:HGNC Symbol;Acc:HGNC:6876] Location: 6:36027752-36122511 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Platelet homeostasis Cytokine Signaling in Immune system Mitochondrial biogenesis MAPK3 Gene Information Basic Information Ensembl ID: ENSG00000102882 Description: mitogen-activated protein kinase 3 [Source:HGNC Symbol;Acc:HGNC:6877] Location: 16:30114105-30123506 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Transmission across Chemical Synapses Signaling by NODAL MCM2 Gene Information Basic Information Ensembl ID: ENSG00000073111 Description: minichromosome maintenance complex component 2 [Source:HGNC Symbol;Acc:HGNC:6944] Location: 3:127598223-127622436 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: DNA Replication Pre-Initiation Synthesis of DNA Cell Cycle, Mitotic MET Gene Information Basic Information Ensembl ID: ENSG00000105976 Description: MET proto-oncogene%2C receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:7029] Location: 7:116672196-116798377 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell pancreatic cell melanocyte Other: MAPK family signaling cascades RNA Polymerase II Transcription Intracellular signaling by second messengers PPARGC1A Gene Information Basic Information Ensembl ID: ENSG00000109819 Description: PPARG coactivator 1 alpha [Source:HGNC Symbol;Acc:HGNC:9237] Location: 4:23755041-23904089 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Mitochondrial biogenesis Epigenetic regulation of gene expression Cellular responses to stress SMARCA4 Gene Information Basic Information Ensembl ID: ENSG00000127616 Description: SWI/SNF related%2C matrix associated%2C actin dependent regulator of chromatin%2C subfamily a%2C member 4 [Source:HGNC Symbol;Acc:HGNC:11100] Location: 19:10960932-11079426 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell epithelial cell fibroblast Other: Cytokine Signaling in Immune system Signaling by WNT Epigenetic regulation of gene expression SOX2 Gene Information Basic Information Ensembl ID: ENSG00000181449 Description: SRY-box transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:11195] Location: 3:181711925-181714436 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell pericyte progenitor cell embryonic cell fibroblast glial cell neural crest cell stem cell cancer stem cell ectodermal cell basal cell Other: Cytokine Signaling in Immune system Signaling by WNT Transcriptional regulation of pluripotent stem cells SOX9 Gene Information Basic Information Ensembl ID: ENSG00000125398 Description: SRY-box transcription factor 9 [Source:HGNC Symbol;Acc:HGNC:11204] Location: 17:72121020-72126416 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stem cell glial cell stromal cell tuft cell fibroblast ionocyte epithelial cell M cell chondrocyte cancer stem cell progenitor cell ductal cell Other: Signaling by WNT RNA Polymerase II Transcription Transcriptional regulation of testis differentiation TCF7 Gene Information Basic Information Ensembl ID: ENSG00000081059 Description: transcription factor 7 [Source:HGNC Symbol;Acc:HGNC:11639] Location: 5:134114681-134151865 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell developing T cell T cell CD4+ T cell Specialized T cell innate lymphoid cell Other: Signaling by WNT RNA Polymerase II Transcription MITF-M-regulated melanocyte development TNFSF11 Gene Information Basic Information Ensembl ID: ENSG00000120659 Description: TNF superfamily member 11 [Source:HGNC Symbol;Acc:HGNC:11926] Location: 13:42562736-42608013 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stem cell Other: Cytokine Signaling in Immune system MITF-M-regulated melanocyte development
MTOR signalling Pathway Hierarchies & Genes Energy dependent regulation of mTOR by LKB1-AMPK (2 genes) Signal Transduction MTOR signalling 1 genes mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK 1 genes Inhibition of TSC complex formation by PKB (1 genes) Signal Transduction MTOR signalling Inhibition of TSC complex formation by PKB 1 genes	AKT1 Gene Information Basic Information Ensembl ID: ENSG00000142208 Description: AKT serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:391] Location: 14:104769349-104795759 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Integrin signaling Apoptosis Cytokine Signaling in Immune system AKT2 Gene Information Basic Information Ensembl ID: ENSG00000105221 Description: AKT serine/threonine kinase 2 [Source:HGNC Symbol;Acc:HGNC:392] Location: 19:40230317-40285536 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: T cell Other: Apoptosis Cytokine Signaling in Immune system Adaptive Immune System MTOR Gene Information Basic Information Ensembl ID: ENSG00000198793 Description: mechanistic target of rapamycin kinase [Source:HGNC Symbol;Acc:HGNC:3942] Location: 1:11106535-11262556 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Adaptive Immune System Macroautophagy MTOR signalling
Macroautophagy Pathway Hierarchies & Genes PINK1-PRKN Mediated Mitophagy (4 genes) Autophagy Macroautophagy 1 genes Selective autophagy Mitophagy 2 genes PINK1-PRKN Mediated Mitophagy 1 genes	ATM Gene Information Basic Information Ensembl ID: ENSG00000149311 Description: ATM serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:795] Location: 11:108222804-108369102 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell T cell phagocyte hematopoietic cell Specialized T cell developing T cell Naive B cell lymphocyte Other: Meiosis Macroautophagy Cellular responses to stress MTOR Gene Information Basic Information Ensembl ID: ENSG00000198793 Description: mechanistic target of rapamycin kinase [Source:HGNC Symbol;Acc:HGNC:3942] Location: 1:11106535-11262556 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Adaptive Immune System Macroautophagy MTOR signalling TBK1 Gene Information Basic Information Ensembl ID: ENSG00000183735 Description: TANK binding kinase 1 [Source:HGNC Symbol;Acc:HGNC:11584] Location: 12:64452090-64502114 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell Other: Cytokine Signaling in Immune system Macroautophagy Innate Immune System VIM Gene Information Basic Information Ensembl ID: ENSG00000026025 Description: vimentin [Source:HGNC Symbol;Acc:HGNC:12692] Location: 10:17228241-17237593 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell pericyte macrophage monocyte stem cell embryonic cell phagocyte fibroblast glial cell smooth muscle cell oligodendrocyte precursor cell bone cell mast cell granulocyte antigen presenting cell interstitial cell mesenchymal cell mesenchymal stem cell Other: Apoptosis Cytokine Signaling in Immune system Macroautophagy
Maternal to zygotic transition (MZT) Pathway Hierarchies & Genes Zygotic genome activation (ZGA) (2 genes) Developmental Biology Maternal to zygotic transition (MZT) Zygotic genome activation (ZGA) 2 genes	CREBBP Gene Information Basic Information Ensembl ID: ENSG00000005339 Description: CREB binding protein [Source:HGNC Symbol;Acc:HGNC:2348] Location: 16:3725054-3880713 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes BMAL1:CLOCK,NPAS2 activates circadian expression TP53 Gene Information Basic Information Ensembl ID: ENSG00000141510 Description: tumor protein p53 [Source:HGNC Symbol;Acc:HGNC:11998] Location: 17:7661779-7687546 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Cytokine Signaling in Immune system Signaling by NOTCH
Meiosis Pathway Hierarchies & Genes Meiotic recombination (2 genes) Reproduction Meiosis Meiotic synapsis 1 genes Meiotic recombination 1 genes Meiotic recombination (5 genes) Reproduction Meiosis Meiotic recombination 5 genes	ATM Gene Information Basic Information Ensembl ID: ENSG00000149311 Description: ATM serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:795] Location: 11:108222804-108369102 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell T cell phagocyte hematopoietic cell Specialized T cell developing T cell Naive B cell lymphocyte Other: Meiosis Macroautophagy Cellular responses to stress ATR Gene Information Basic Information Ensembl ID: ENSG00000175054 Description: ATR serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:882] Location: 3:142449007-142578733 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Meiosis Cellular responses to stress DNA Double-Strand Break Repair BRCA1 Gene Information Basic Information Ensembl ID: ENSG00000012048 Description: BRCA1 DNA repair associated [Source:HGNC Symbol;Acc:HGNC:1100] Location: 17:43044295-43170245 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: cancer cell Other: Meiosis Cellular responses to stress DNA Double-Strand Break Repair CDK2 Gene Information Basic Information Ensembl ID: ENSG00000123374 Description: cyclin dependent kinase 2 [Source:HGNC Symbol;Acc:HGNC:1771] Location: 12:55966781-55972789 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Meiosis Cellular responses to stress DNA Double-Strand Break Repair CDK4 Gene Information Basic Information Ensembl ID: ENSG00000135446 Description: cyclin dependent kinase 4 [Source:HGNC Symbol;Acc:HGNC:1773] Location: 12:57747727-57756013 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: T cell schwann cell progenitor cell neural crest cell Other: Adipogenesis Meiosis Cellular responses to stress MLH1 Gene Information Basic Information Ensembl ID: ENSG00000076242 Description: mutL homolog 1 [Source:HGNC Symbol;Acc:HGNC:7127] Location: 3:36993226-37050896 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Meiosis Mismatch Repair RNA Polymerase II Transcription RAD51 Gene Information Basic Information Ensembl ID: ENSG00000051180 Description: RAD51 recombinase [Source:HGNC Symbol;Acc:HGNC:9817] Location: 15:40694774-40732340 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Meiosis DNA Double-Strand Break Repair RNA Polymerase II Transcription
Membrane Trafficking Pathway Hierarchies & Genes Cargo recognition for clathrin-mediated endocytosis (1 genes) Vesicle-mediated transport Membrane Trafficking trans-Golgi Network Vesicle Budding Golgi Associated Vesicle Biogenesis Intra-Golgi and retrograde Golgi-to-ER traffic Retrograde transport at the Trans-Golgi-Network Clathrin-mediated endocytosis Cargo recognition for clathrin-mediated endocytosis 1 genes RAB GEFs exchange GTP for GDP on RABs (2 genes) Vesicle-mediated transport Membrane Trafficking Translocation of SLC2A4 (GLUT4) to the plasma membrane Rab regulation of trafficking RAB GEFs exchange GTP for GDP on RABs 2 genes Cargo recognition for clathrin-mediated endocytosis (5 genes) Vesicle-mediated transport Membrane Trafficking Clathrin-mediated endocytosis Cargo recognition for clathrin-mediated endocytosis 5 genes RAB GEFs exchange GTP for GDP on RABs (1 genes) Vesicle-mediated transport Membrane Trafficking Rab regulation of trafficking RAB GEFs exchange GTP for GDP on RABs 1 genes	AKT1 Gene Information Basic Information Ensembl ID: ENSG00000142208 Description: AKT serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:391] Location: 14:104769349-104795759 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Integrin signaling Apoptosis Cytokine Signaling in Immune system AKT2 Gene Information Basic Information Ensembl ID: ENSG00000105221 Description: AKT serine/threonine kinase 2 [Source:HGNC Symbol;Acc:HGNC:392] Location: 19:40230317-40285536 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: T cell Other: Apoptosis Cytokine Signaling in Immune system Adaptive Immune System AKT3 Gene Information Basic Information Ensembl ID: ENSG00000117020 Description: AKT serine/threonine kinase 3 [Source:HGNC Symbol;Acc:HGNC:393] Location: 1:243488233-243851079 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell neuron epithelial cell T cell fibroblast glial cell CD8+ T cell schwann cell Specialized T cell excitatory neuron smooth muscle cell Other: Apoptosis Cytokine Signaling in Immune system Adaptive Immune System CD3D Gene Information Basic Information Ensembl ID: ENSG00000167286 Description: CD3 delta subunit of T-cell receptor complex [Source:HGNC Symbol;Acc:HGNC:1673] Location: 11:118334537-118342705 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell CD8+ T cell developing T cell lymphocyte T cell Specialized T cell Regulatory T cell CD4+ T cell Other: Adaptive Immune System Membrane Trafficking CD4 Gene Information Basic Information Ensembl ID: ENSG00000010610 Description: CD4 molecule [Source:HGNC Symbol;Acc:HGNC:1678] Location: 12:6786858-6820799 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell dendritic cell phagocyte CD4+ T cell antigen presenting cell hematopoietic cell monocyte macrophage developing T cell Regulatory T cell T cell memory T cell Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System EGF Gene Information Basic Information Ensembl ID: ENSG00000138798 Description: epidermal growth factor [Source:HGNC Symbol;Acc:HGNC:3229] Location: 4:109912883-110013766 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: skeletal muscle cell epithelial cell glial cell Other: Signaling by NOTCH Membrane Trafficking Cellular responses to stress EGFR Gene Information Basic Information Ensembl ID: ENSG00000146648 Description: epidermal growth factor receptor [Source:HGNC Symbol;Acc:HGNC:3236] Location: 7:55019017-55211628 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell endothelial cell trophoblast cell hepatocyte stem cell adipocyte fibroblast muscle cell stromal cell mesenchymal stem cell skeletal muscle cell cancer cell Other: Signaling by NOTCH Membrane Trafficking Signaling by GPCR IGF2R Gene Information Basic Information Ensembl ID: ENSG00000197081 Description: insulin like growth factor 2 receptor [Source:HGNC Symbol;Acc:HGNC:5467] Location: 6:159969082-160113507 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell granulocyte neutrophil myeloid cell dendritic cell Other: Innate Immune System Membrane Trafficking WNT5A Gene Information Basic Information Ensembl ID: ENSG00000114251 Description: Wnt family member 5A [Source:HGNC Symbol;Acc:HGNC:12784] Location: 3:55465715-55490539 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: fibroblast mesenchymal cell Other: Signaling by WNT Membrane Trafficking Signaling by GPCR
Metabolism of amino acids and derivatives Pathway Hierarchies & Genes Tryptophan catabolism (1 genes) Metabolism Metabolism of amino acids and derivatives Tryptophan catabolism 1 genes Urea cycle (1 genes) Metabolism Metabolism of amino acids and derivatives Urea cycle 1 genes	ARG1 Gene Information Basic Information Ensembl ID: ENSG00000118520 Description: arginase 1 [Source:HGNC Symbol;Acc:HGNC:663] Location: 6:131470832-131584332 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Innate Immune System Metabolism of amino acids and derivatives IDO1 Gene Information Basic Information Ensembl ID: ENSG00000131203 Description: indoleamine 2%2C3-dioxygenase 1 [Source:HGNC Symbol;Acc:HGNC:6059] Location: 8:39902275-39928790 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell epithelial cell Other: Metabolism of amino acids and derivatives
Metabolism of carbohydrates and carbohydrate derivatives Pathway Hierarchies & Genes Pentose phosphate pathway (1 genes) Metabolism Metabolism of carbohydrates and carbohydrate derivatives Pentose phosphate pathway 1 genes	G6PD Gene Information Basic Information Ensembl ID: ENSG00000160211 Description: glucose-6-phosphate dehydrogenase [Source:HGNC Symbol;Acc:HGNC:4057] Location: X:154517825-154547572 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Specialized T cell natural killer cell Other: Cellular responses to stress Metabolism of carbohydrates and carbohydrate derivatives RNA Polymerase II Transcription
Metabolism of lipids Pathway Hierarchies & Genes Biosynthesis of DPAn-3 SPMs (1 genes) Metabolism Metabolism of lipids Fatty acid metabolism Arachidonate metabolism Synthesis of 15-eicosatetraenoic acid derivatives Biosynthesis of specialized proresolving mediators (SPMs) Biosynthesis of DPA-derived SPMs Biosynthesis of DPAn-3 SPMs 1 genes PPARA activates gene expression (1 genes) Metabolism Metabolism of lipids Metabolism of steroids Regulation of cholesterol biosynthesis by SREBP (SREBF) Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by PPARalpha PPARA activates gene expression 1 genes Glucocorticoid biosynthesis (1 genes) Metabolism Metabolism of lipids Metabolism of steroids Metabolism of steroid hormones Glucocorticoid biosynthesis 1 genes Synthesis of PIPs at the plasma membrane (3 genes) Metabolism Metabolism of lipids Phospholipid metabolism PI Metabolism Synthesis of PIPs at the plasma membrane 3 genes PPARA activates gene expression (3 genes) Metabolism Metabolism of lipids Regulation of lipid metabolism by PPARalpha PPARA activates gene expression 3 genes	CREBBP Gene Information Basic Information Ensembl ID: ENSG00000005339 Description: CREB binding protein [Source:HGNC Symbol;Acc:HGNC:2348] Location: 16:3725054-3880713 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes BMAL1:CLOCK,NPAS2 activates circadian expression HDAC3 Gene Information Basic Information Ensembl ID: ENSG00000171720 Description: histone deacetylase 3 [Source:HGNC Symbol;Acc:HGNC:4854] Location: 5:141620876-141636849 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Death Receptor Signaling Signaling by NOTCH Mitochondrial biogenesis HSD11B1 Gene Information Basic Information Ensembl ID: ENSG00000117594 Description: hydroxysteroid 11-beta dehydrogenase 1 [Source:HGNC Symbol;Acc:HGNC:5208] Location: 1:209686178-209734949 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: fibroblast adipocyte Other: Metabolism of lipids Prednisone ADME PIK3CA Gene Information Basic Information Ensembl ID: ENSG00000121879 Description: phosphatidylinositol-4%2C5-bisphosphate 3-kinase catalytic subunit alpha [Source:HGNC Symbol;Acc:HGNC:8975] Location: 3:179148114-179240093 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System PIK3CD Gene Information Basic Information Ensembl ID: ENSG00000171608 Description: phosphatidylinositol-4%2C5-bisphosphate 3-kinase catalytic subunit delta [Source:HGNC Symbol;Acc:HGNC:8977] Location: 1:9629889-9729114 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: developing T cell T cell hematopoietic cell Other: Cytokine Signaling in Immune system Adaptive Immune System Metabolism of lipids PIK3CG Gene Information Basic Information Ensembl ID: ENSG00000105851 Description: phosphatidylinositol-4%2C5-bisphosphate 3-kinase catalytic subunit gamma [Source:HGNC Symbol;Acc:HGNC:8978] Location: 7:106865278-106908980 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: tuft cell Other: Adaptive Immune System Signaling by GPCR Metabolism of lipids PPARG Gene Information Basic Information Ensembl ID: ENSG00000132170 Description: peroxisome proliferator activated receptor gamma [Source:HGNC Symbol;Acc:HGNC:9236] Location: 3:12287368-12434356 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell pericyte epithelial cell stem cell phagocyte adipocyte macrophage tuft cell Other: Epigenetic regulation of gene expression Metabolism of lipids Post-translational protein modification PPARGC1A Gene Information Basic Information Ensembl ID: ENSG00000109819 Description: PPARG coactivator 1 alpha [Source:HGNC Symbol;Acc:HGNC:9237] Location: 4:23755041-23904089 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Mitochondrial biogenesis Epigenetic regulation of gene expression Cellular responses to stress PTGS2 Gene Information Basic Information Ensembl ID: ENSG00000073756 Description: prostaglandin-endoperoxide synthase 2 [Source:HGNC Symbol;Acc:HGNC:9605] Location: 1:186671791-186680922 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell endothelial cell fibroblast macrophage phagocyte mast cell granulocyte dendritic cell monocyte epithelial cell Other: Cytokine Signaling in Immune system Metabolism of lipids
Metabolism of nitric oxide: NOS3 activation and regulation Pathway Hierarchies & Genes eNOS activation (1 genes) Metabolism Metabolism of nitric oxide: NOS3 activation and regulation eNOS activation 1 genes	AKT1 Gene Information Basic Information Ensembl ID: ENSG00000142208 Description: AKT serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:391] Location: 14:104769349-104795759 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Integrin signaling Apoptosis Cytokine Signaling in Immune system
Metabolism of nucleotides Pathway Hierarchies & Genes Phosphate bond hydrolysis by NTPDase proteins (1 genes) Metabolism Metabolism of nucleotides Nucleotide catabolism Phosphate bond hydrolysis by NTPDase proteins 1 genes Pyrimidine catabolism (1 genes) Metabolism Metabolism of nucleotides Nucleotide catabolism Pyrimidine catabolism 1 genes	ENTPD1 Gene Information Basic Information Ensembl ID: ENSG00000138185 Description: ectonucleoside triphosphate diphosphohydrolase 1 [Source:HGNC Symbol;Acc:HGNC:3363] Location: 10:95711779-95877266 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell endothelial cell monocyte Specialized T cell leukocyte granulocyte T cell Regulatory T cell macrophage CD8+ T cell Other: Metabolism of nucleotides Parasitic Infection Pathways NT5E Gene Information Basic Information Ensembl ID: ENSG00000135318 Description: 5'-nucleotidase ecto [Source:HGNC Symbol;Acc:HGNC:8021] Location: 6:85449584-85495791 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: trophoblast cell epithelial cell stem cell pericyte mesenchymal stem cell stromal cell progenitor cell fibroblast Naive B cell activated B cell Other: Metabolism of nucleotides Metabolism of vitamins and cofactors Parasitic Infection Pathways
Metabolism of vitamins and cofactors Pathway Hierarchies & Genes NADPH regeneration (1 genes) Metabolism Metabolism of vitamins and cofactors Metabolism of cofactors NADPH regeneration 1 genes Nicotinate metabolism (2 genes) Metabolism Metabolism of vitamins and cofactors Metabolism of water-soluble vitamins and cofactors Nicotinate metabolism 2 genes Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (1 genes) Metabolism Metabolism of vitamins and cofactors Metabolism of cofactors Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 1 genes	AKT1 Gene Information Basic Information Ensembl ID: ENSG00000142208 Description: AKT serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:391] Location: 14:104769349-104795759 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Integrin signaling Apoptosis Cytokine Signaling in Immune system CD38 Gene Information Basic Information Ensembl ID: ENSG00000004468 Description: CD38 molecule [Source:HGNC Symbol;Acc:HGNC:1667] Location: 4:15778275-15853232 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell natural killer cell pericyte plasma cell lymphoid progenitor cell plasmablast activated B cell plasma B cell basal cell memory B cell primordial germ cell CD8+ T cell Regulatory T cell Other: Metabolism of vitamins and cofactors IDH1 Gene Information Basic Information Ensembl ID: ENSG00000138413 Description: isocitrate dehydrogenase (NADP(+)) 1 [Source:HGNC Symbol;Acc:HGNC:5382] Location: 2:208236229-208266074 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Innate Immune System Metabolism of vitamins and cofactors Cellular responses to stress NT5E Gene Information Basic Information Ensembl ID: ENSG00000135318 Description: 5'-nucleotidase ecto [Source:HGNC Symbol;Acc:HGNC:8021] Location: 6:85449584-85495791 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: trophoblast cell epithelial cell stem cell pericyte mesenchymal stem cell stromal cell progenitor cell fibroblast Naive B cell activated B cell Other: Metabolism of nucleotides Metabolism of vitamins and cofactors Parasitic Infection Pathways
Mismatch Repair Pathway Hierarchies & Genes Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (3 genes) DNA Repair Mismatch Repair Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 1 genes Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 2 genes	MLH1 Gene Information Basic Information Ensembl ID: ENSG00000076242 Description: mutL homolog 1 [Source:HGNC Symbol;Acc:HGNC:7127] Location: 3:36993226-37050896 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Meiosis Mismatch Repair RNA Polymerase II Transcription MSH2 Gene Information Basic Information Ensembl ID: ENSG00000095002 Description: mutS homolog 2 [Source:HGNC Symbol;Acc:HGNC:7325] Location: 2:47403067-47663146 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Diseases of Mismatch Repair (MMR) Mismatch Repair RNA Polymerase II Transcription MSH6 Gene Information Basic Information Ensembl ID: ENSG00000116062 Description: mutS homolog 6 [Source:HGNC Symbol;Acc:HGNC:7329] Location: 2:47695530-47810063 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Diseases of Mismatch Repair (MMR) Mismatch Repair
Mitochondrial biogenesis Pathway Hierarchies & Genes Activation of PPARGC1A (PGC-1alpha) by phosphorylation (3 genes) Organelle biogenesis and maintenance Mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis 2 genes Activation of PPARGC1A (PGC-1alpha) by phosphorylation 1 genes Activation of PPARGC1A (PGC-1alpha) by phosphorylation (1 genes) Organelle biogenesis and maintenance Mitochondrial biogenesis Activation of PPARGC1A (PGC-1alpha) by phosphorylation 1 genes	CREBBP Gene Information Basic Information Ensembl ID: ENSG00000005339 Description: CREB binding protein [Source:HGNC Symbol;Acc:HGNC:2348] Location: 16:3725054-3880713 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes BMAL1:CLOCK,NPAS2 activates circadian expression HDAC3 Gene Information Basic Information Ensembl ID: ENSG00000171720 Description: histone deacetylase 3 [Source:HGNC Symbol;Acc:HGNC:4854] Location: 5:141620876-141636849 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Death Receptor Signaling Signaling by NOTCH Mitochondrial biogenesis MAPK14 Gene Information Basic Information Ensembl ID: ENSG00000112062 Description: mitogen-activated protein kinase 14 [Source:HGNC Symbol;Acc:HGNC:6876] Location: 6:36027752-36122511 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Platelet homeostasis Cytokine Signaling in Immune system Mitochondrial biogenesis PPARGC1A Gene Information Basic Information Ensembl ID: ENSG00000109819 Description: PPARG coactivator 1 alpha [Source:HGNC Symbol;Acc:HGNC:9237] Location: 4:23755041-23904089 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Mitochondrial biogenesis Epigenetic regulation of gene expression Cellular responses to stress
Myogenesis Pathway Hierarchies & Genes Myogenesis (3 genes) Developmental Biology Myogenesis 3 genes	ABL1 Gene Information Basic Information Ensembl ID: ENSG00000097007 Description: ABL proto-oncogene 1%2C non-receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:76] Location: 9:130713043-130887675 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Innate Immune System Epigenetic regulation of gene expression Myogenesis CTNNB1 Gene Information Basic Information Ensembl ID: ENSG00000168036 Description: catenin beta 1 [Source:HGNC Symbol;Acc:HGNC:2514] Location: 3:41194741-41260096 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell endothelial cell epithelial cell stem cell phagocyte adrenal cortical cell fibroblast monocyte Specialized T cell melanocyte M cell Other: Apoptosis Innate Immune System Signaling by WNT MAPK14 Gene Information Basic Information Ensembl ID: ENSG00000112062 Description: mitogen-activated protein kinase 14 [Source:HGNC Symbol;Acc:HGNC:6876] Location: 6:36027752-36122511 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Platelet homeostasis Cytokine Signaling in Immune system Mitochondrial biogenesis
Nephrin family interactions Pathway Hierarchies & Genes Nephrin family interactions (2 genes) Cell-Cell communication Nephrin family interactions 2 genes	FYN Gene Information Basic Information Ensembl ID: ENSG00000010810 Description: FYN proto-oncogene%2C Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:4037] Location: 6:111660332-111873452 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Cellular responses to mechanical stimuli PIK3CA Gene Information Basic Information Ensembl ID: ENSG00000121879 Description: phosphatidylinositol-4%2C5-bisphosphate 3-kinase catalytic subunit alpha [Source:HGNC Symbol;Acc:HGNC:8975] Location: 3:179148114-179240093 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System
Nervous system development Pathway Hierarchies & Genes Sema4D mediated inhibition of cell attachment and migration (1 genes) Developmental Biology Nervous system development Axon guidance Semaphorin interactions Sema4D in semaphorin signaling Sema4D mediated inhibition of cell attachment and migration 1 genes CHL1 interactions (1 genes) Developmental Biology Nervous system development Axon guidance L1CAM interactions CHL1 interactions 1 genes EPH-ephrin mediated repulsion of cells (2 genes) Developmental Biology Nervous system development Axon guidance EPH-Ephrin signaling EPH-ephrin mediated repulsion of cells 2 genes EPHA-mediated growth cone collapse (1 genes) Developmental Biology Nervous system development Axon guidance EPH-Ephrin signaling EPHA-mediated growth cone collapse 1 genes EPHB-mediated forward signaling (3 genes) Developmental Biology Nervous system development Axon guidance EPH-Ephrin signaling EPHB-mediated forward signaling 3 genes NCAM1 interactions (2 genes) Developmental Biology Nervous system development Axon guidance NCAM signaling for neurite out-growth NCAM1 interactions 2 genes Netrin mediated repulsion signals (1 genes) Developmental Biology Nervous system development Axon guidance Netrin-1 signaling Netrin mediated repulsion signals 1 genes Other semaphorin interactions (4 genes) Developmental Biology Nervous system development Axon guidance Semaphorin interactions Other semaphorin interactions 4 genes ROBO receptors bind AKAP5 (1 genes) Developmental Biology Nervous system development Axon guidance Signaling by ROBO receptors ROBO receptors bind AKAP5 1 genes Recycling pathway of L1 (1 genes) Developmental Biology Nervous system development Axon guidance L1CAM interactions Recycling pathway of L1 1 genes Role of ABL in ROBO-SLIT signaling (1 genes) Developmental Biology Nervous system development Axon guidance Signaling by ROBO receptors Role of ABL in ROBO-SLIT signaling 1 genes Sema3A PAK dependent Axon repulsion (1 genes) Developmental Biology Nervous system development Axon guidance Semaphorin interactions Sema3A PAK dependent Axon repulsion 1 genes Signal transduction by L1 (7 genes) Developmental Biology Nervous system development Axon guidance L1CAM interactions Signal transduction by L1 7 genes NCAM signaling for neurite out-growth (2 genes) Developmental Biology Nervous system development Axon guidance NCAM signaling for neurite out-growth 2 genes RET signaling (2 genes) Developmental Biology Nervous system development Axon guidance RET signaling 2 genes Signaling by ROBO receptors (1 genes) Developmental Biology Nervous system development Axon guidance Signaling by ROBO receptors 1 genes EGR2 and SOX10-mediated initiation of Schwann cell myelination (1 genes) Developmental Biology Nervous system development EGR2 and SOX10-mediated initiation of Schwann cell myelination 1 genes	ABL1 Gene Information Basic Information Ensembl ID: ENSG00000097007 Description: ABL proto-oncogene 1%2C non-receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:76] Location: 9:130713043-130887675 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Innate Immune System Epigenetic regulation of gene expression Myogenesis COL5A1 Gene Information Basic Information Ensembl ID: ENSG00000130635 Description: collagen type V alpha 1 chain [Source:HGNC Symbol;Acc:HGNC:2209] Location: 9:134641803-134844843 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron pericyte stromal cell stellate cell fibroblast stem cell embryonic cell mesenchymal cell skeletal muscle cell Other: Degradation of the extracellular matrix Collagen formation Fibronectin matrix formation CXCL12 Gene Information Basic Information Ensembl ID: ENSG00000107562 Description: C-X-C motif chemokine ligand 12 [Source:HGNC Symbol;Acc:HGNC:10672] Location: 10:44370165-44386493 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stromal cell thymic epithelial cell stem cell endothelial cell fibroblast mesodermal cell smooth muscle cell antigen presenting cell mesenchymal cell mural cell preadipocyte adipocyte medullary reticular cell Other: Signaling by GPCR Signaling by Nuclear Receptors Signaling by Receptor Tyrosine Kinases EGFR Gene Information Basic Information Ensembl ID: ENSG00000146648 Description: epidermal growth factor receptor [Source:HGNC Symbol;Acc:HGNC:3236] Location: 7:55019017-55211628 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell endothelial cell trophoblast cell hepatocyte stem cell adipocyte fibroblast muscle cell stromal cell mesenchymal stem cell skeletal muscle cell cancer cell Other: Signaling by NOTCH Membrane Trafficking Signaling by GPCR EPHA2 Gene Information Basic Information Ensembl ID: ENSG00000142627 Description: EPH receptor A2 [Source:HGNC Symbol;Acc:HGNC:3386] Location: 1:16124337-16156069 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stem cell epithelial cell Other: Nervous system development Signaling by Rho GTPases, Miro GTPases and RHOBTB3 FGFR1 Gene Information Basic Information Ensembl ID: ENSG00000077782 Description: fibroblast growth factor receptor 1 [Source:HGNC Symbol;Acc:HGNC:3688] Location: 8:38400215-38468834 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell fibroblast epithelial cell stem cell stromal cell Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases FYN Gene Information Basic Information Ensembl ID: ENSG00000010810 Description: FYN proto-oncogene%2C Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:4037] Location: 6:111660332-111873452 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Cellular responses to mechanical stimuli HRAS Gene Information Basic Information Ensembl ID: ENSG00000174775 Description: HRas proto-oncogene%2C GTPase [Source:HGNC Symbol;Acc:HGNC:5173] Location: 11:532242-537321 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Transmission across Chemical Synapses Cytokine Signaling in Immune system Adaptive Immune System ITGA1 Gene Information Basic Information Ensembl ID: ENSG00000213949 Description: integrin subunit alpha 1 [Source:HGNC Symbol;Acc:HGNC:6134] Location: 5:52787916-52959209 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell pericyte developing T cell epithelial cell fibroblast glial cell stromal cell Specialized T cell smooth muscle cell CD8+ T cell T cell mesenchymal cell lymphocyte beta cell memory T cell Other: Integrin cell surface interactions Laminin interactions Smooth Muscle Contraction ITGA2 Gene Information Basic Information Ensembl ID: ENSG00000164171 Description: integrin subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:6137] Location: 5:52989340-53094779 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell stem cell pancreatic cell goblet cell Other: Integrin cell surface interactions Laminin interactions Non-integrin membrane-ECM interactions ITGA5 Gene Information Basic Information Ensembl ID: ENSG00000161638 Description: integrin subunit alpha 5 [Source:HGNC Symbol;Acc:HGNC:6141] Location: 12:54395261-54419266 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell epithelial cell stromal cell smooth muscle cell trophoblast cell mesenchymal stem cell fibroblast Other: Elastic fibre formation Fibronectin matrix formation Cell surface interactions at the vascular wall ITGAV Gene Information Basic Information Ensembl ID: ENSG00000138448 Description: integrin subunit alpha V [Source:HGNC Symbol;Acc:HGNC:6150] Location: 2:186590010-186680901 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell glial cell stromal cell M cell endothelial cell Other: Adaptive Immune System Elastic fibre formation Innate Immune System ITGB1 Gene Information Basic Information Ensembl ID: ENSG00000150093 Description: integrin subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:6153] Location: 10:32887273-33005792 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stellate cell pericyte trophoblast cell epithelial cell stromal cell stem cell endothelial cell smooth muscle cell fibroblast mesenchymal stem cell Other: Laminin interactions Cell surface interactions at the vascular wall Cytokine Signaling in Immune system ITGB3 Gene Information Basic Information Ensembl ID: ENSG00000259207 Description: integrin subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:6156] Location: 17:47253827-47313743 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: platelet epithelial cell monocyte Other: ECM proteoglycans Elastic fibre formation Cell surface interactions at the vascular wall KRAS Gene Information Basic Information Ensembl ID: ENSG00000133703 Description: KRAS proto-oncogene%2C GTPase [Source:HGNC Symbol;Acc:HGNC:6407] Location: 12:25205246-25250936 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Signaling by Non-Receptor Tyrosine Kinases Transmission across Chemical Synapses Cytokine Signaling in Immune system LYN Gene Information Basic Information Ensembl ID: ENSG00000254087 Description: LYN proto-oncogene%2C Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6735] Location: 8:55879835-56014169 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System MAP2K1 Gene Information Basic Information Ensembl ID: ENSG00000169032 Description: mitogen-activated protein kinase kinase 1 [Source:HGNC Symbol;Acc:HGNC:6840] Location: 15:66386837-66491656 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Innate Immune System MAPK family signaling cascades MAPK1 Gene Information Basic Information Ensembl ID: ENSG00000100030 Description: mitogen-activated protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:6871] Location: 22:21759657-21867680 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Transmission across Chemical Synapses Signaling by NODAL MAPK3 Gene Information Basic Information Ensembl ID: ENSG00000102882 Description: mitogen-activated protein kinase 3 [Source:HGNC Symbol;Acc:HGNC:6877] Location: 16:30114105-30123506 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Transmission across Chemical Synapses Signaling by NODAL MET Gene Information Basic Information Ensembl ID: ENSG00000105976 Description: MET proto-oncogene%2C receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:7029] Location: 7:116672196-116798377 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell pancreatic cell melanocyte Other: MAPK family signaling cascades RNA Polymerase II Transcription Intracellular signaling by second messengers MMP2 Gene Information Basic Information Ensembl ID: ENSG00000087245 Description: matrix metallopeptidase 2 [Source:HGNC Symbol;Acc:HGNC:7166] Location: 16:55389700-55506691 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: mesenchymal cell smooth muscle cell Other: Cytokine Signaling in Immune system Degradation of the extracellular matrix Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MMP9 Gene Information Basic Information Ensembl ID: ENSG00000100985 Description: matrix metallopeptidase 9 [Source:HGNC Symbol;Acc:HGNC:7176] Location: 20:46008908-46016561 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell macrophage phagocyte neutrophil monocyte osteoclast Other: Cytokine Signaling in Immune system Degradation of the extracellular matrix Collagen formation NCAM1 Gene Information Basic Information Ensembl ID: ENSG00000149294 Description: neural cell adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:7656] Location: 11:112961275-113278436 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron natural killer cell interneuron pericyte T cell glial cell smooth muscle cell motor neuron Specialized T cell innate lymphoid cell chromaffin cell epithelial cell neuroendocrine cell lymphocyte cancer stem cell progenitor cell stem cell mesenchymal stem cell immune cell cancer cell autonomic neuron Other: ECM proteoglycans Cytokine Signaling in Immune system MAPK family signaling cascades NRAS Gene Information Basic Information Ensembl ID: ENSG00000213281 Description: NRAS proto-oncogene%2C GTPase [Source:HGNC Symbol;Acc:HGNC:7989] Location: 1:114704469-114716771 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell cancer cell Other: Signaling by Erythropoietin Signaling by Non-Receptor Tyrosine Kinases Signaling by Nuclear Receptors NRP1 Gene Information Basic Information Ensembl ID: ENSG00000099250 Description: neuropilin 1 [Source:HGNC Symbol;Acc:HGNC:8004] Location: 10:33177492-33336262 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Signaling by Receptor Tyrosine Kinases Nervous system development Viral Infection Pathways PIK3CA Gene Information Basic Information Ensembl ID: ENSG00000121879 Description: phosphatidylinositol-4%2C5-bisphosphate 3-kinase catalytic subunit alpha [Source:HGNC Symbol;Acc:HGNC:8975] Location: 3:179148114-179240093 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System PIK3CD Gene Information Basic Information Ensembl ID: ENSG00000171608 Description: phosphatidylinositol-4%2C5-bisphosphate 3-kinase catalytic subunit delta [Source:HGNC Symbol;Acc:HGNC:8977] Location: 1:9629889-9729114 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: developing T cell T cell hematopoietic cell Other: Cytokine Signaling in Immune system Adaptive Immune System Metabolism of lipids PRKCA Gene Information Basic Information Ensembl ID: ENSG00000154229 Description: protein kinase C alpha [Source:HGNC Symbol;Acc:HGNC:9393] Location: 17:66302613-66810743 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: bipolar cell Other: Transmission across Chemical Synapses Integration of energy metabolism Signaling by WNT PTPN11 Gene Information Basic Information Ensembl ID: ENSG00000179295 Description: protein tyrosine phosphatase non-receptor type 11 [Source:HGNC Symbol;Acc:HGNC:9644] Location: 12:112418351-112509918 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System PTPRC Gene Information Basic Information Ensembl ID: ENSG00000081237 Description: protein tyrosine phosphatase receptor type C [Source:HGNC Symbol;Acc:HGNC:9666] Location: 1:198638457-198759342 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell CD8+ T cell developing T cell T cell phagocyte monocyte CD4+ T cell leukocyte hematopoietic cell lymphocyte hematopoietic stem cell stromal cell fibroblast immune cell myeloid cell dendritic cell plasma cell neutrophil mesenchymal stem cell epithelial cell endothelial cell macrophage mast cell stem cell Other: Adaptive Immune System Innate Immune System Nervous system development SMARCA4 Gene Information Basic Information Ensembl ID: ENSG00000127616 Description: SWI/SNF related%2C matrix associated%2C actin dependent regulator of chromatin%2C subfamily a%2C member 4 [Source:HGNC Symbol;Acc:HGNC:11100] Location: 19:10960932-11079426 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell epithelial cell fibroblast Other: Cytokine Signaling in Immune system Signaling by WNT Epigenetic regulation of gene expression TREM2 Gene Information Basic Information Ensembl ID: ENSG00000095970 Description: triggering receptor expressed on myeloid cells 2 [Source:HGNC Symbol;Acc:HGNC:17761] Location: 6:41158506-41163186 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron macrophage dendritic cell phagocyte monocyte antigen presenting cell microglia Other: Adaptive Immune System Innate Immune System Nervous system development
Non-integrin membrane-ECM interactions Pathway Hierarchies & Genes Formation of the dystrophin-glycoprotein complex (DGC) (1 genes) Extracellular matrix organization Non-integrin membrane-ECM interactions Formation of the dystrophin-glycoprotein complex (DGC) 1 genes Syndecan interactions (16 genes) Extracellular matrix organization Non-integrin membrane-ECM interactions 3 genes Syndecan interactions 13 genes	COL11A1 Gene Information Basic Information Ensembl ID: ENSG00000060718 Description: collagen type XI alpha 1 chain [Source:HGNC Symbol;Acc:HGNC:2186] Location: 1:102876467-103108872 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte fibroblast stromal cell oligodendrocyte precursor cell melanocyte oligodendrocyte Other: Degradation of the extracellular matrix Collagen formation Non-integrin membrane-ECM interactions COL5A1 Gene Information Basic Information Ensembl ID: ENSG00000130635 Description: collagen type V alpha 1 chain [Source:HGNC Symbol;Acc:HGNC:2209] Location: 9:134641803-134844843 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron pericyte stromal cell stellate cell fibroblast stem cell embryonic cell mesenchymal cell skeletal muscle cell Other: Degradation of the extracellular matrix Collagen formation Fibronectin matrix formation FGF2 Gene Information Basic Information Ensembl ID: ENSG00000138685 Description: fibroblast growth factor 2 [Source:HGNC Symbol;Acc:HGNC:3676] Location: 4:122826682-122898236 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: fibroblast glial cell adipocyte Other: Non-integrin membrane-ECM interactions Cytokine Signaling in Immune system Transcriptional regulation of pluripotent stem cells FN1 Gene Information Basic Information Ensembl ID: ENSG00000115414 Description: fibronectin 1 [Source:HGNC Symbol;Acc:HGNC:3778] Location: 2:215360440-215436073 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell fibroblast endocrine cell pericyte epithelial cell stellate cell stem cell phagocyte muscle cell stromal cell smooth muscle cell thymic epithelial cell skeletal muscle cell mesenchymal cell Other: Cytokine Signaling in Immune system Degradation of the extracellular matrix Elastic fibre formation ITGA2 Gene Information Basic Information Ensembl ID: ENSG00000164171 Description: integrin subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:6137] Location: 5:52989340-53094779 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell stem cell pancreatic cell goblet cell Other: Integrin cell surface interactions Laminin interactions Non-integrin membrane-ECM interactions ITGA6 Gene Information Basic Information Ensembl ID: ENSG00000091409 Description: integrin subunit alpha 6 [Source:HGNC Symbol;Acc:HGNC:6142] Location: 2:172234216-172506459 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell goblet cell kidney cell pericyte epithelial cell embryonic cell stem cell glial cell stromal cell Other: Collagen formation Cell surface interactions at the vascular wall Integrin cell surface interactions ITGAV Gene Information Basic Information Ensembl ID: ENSG00000138448 Description: integrin subunit alpha V [Source:HGNC Symbol;Acc:HGNC:6150] Location: 2:186590010-186680901 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell glial cell stromal cell M cell endothelial cell Other: Adaptive Immune System Elastic fibre formation Innate Immune System ITGB1 Gene Information Basic Information Ensembl ID: ENSG00000150093 Description: integrin subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:6153] Location: 10:32887273-33005792 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stellate cell pericyte trophoblast cell epithelial cell stromal cell stem cell endothelial cell smooth muscle cell fibroblast mesenchymal stem cell Other: Laminin interactions Cell surface interactions at the vascular wall Cytokine Signaling in Immune system ITGB3 Gene Information Basic Information Ensembl ID: ENSG00000259207 Description: integrin subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:6156] Location: 17:47253827-47313743 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: platelet epithelial cell monocyte Other: ECM proteoglycans Elastic fibre formation Cell surface interactions at the vascular wall ITGB4 Gene Information Basic Information Ensembl ID: ENSG00000132470 Description: integrin subunit beta 4 [Source:HGNC Symbol;Acc:HGNC:6158] Location: 17:75721328-75757818 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron epithelial cell schwann cell astrocyte dendritic cell M cell endothelial cell Other: Collagen formation Laminin interactions Non-integrin membrane-ECM interactions LAMB3 Gene Information Basic Information Ensembl ID: ENSG00000196878 Description: laminin subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:6490] Location: 1:209614870-209652425 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell stem cell pancreatic cell goblet cell M cell Other: Degradation of the extracellular matrix Collagen formation Laminin interactions LAMC2 Gene Information Basic Information Ensembl ID: ENSG00000058085 Description: laminin subunit gamma 2 [Source:HGNC Symbol;Acc:HGNC:6493] Location: 1:183186238-183245127 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell pancreatic cell goblet cell M cell stem cell Other: Degradation of the extracellular matrix Collagen formation Laminin interactions PDGFA Gene Information Basic Information Ensembl ID: ENSG00000197461 Description: platelet derived growth factor subunit A [Source:HGNC Symbol;Acc:HGNC:8799] Location: 7:497258-520296 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte smooth muscle cell Specialized T cell secretory cell Other: Cellular responses to stress Non-integrin membrane-ECM interactions MAPK family signaling cascades PDGFB Gene Information Basic Information Ensembl ID: ENSG00000100311 Description: platelet derived growth factor subunit B [Source:HGNC Symbol;Acc:HGNC:8800] Location: 22:39223359-39244982 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell Other: Non-integrin membrane-ECM interactions MAPK family signaling cascades Platelet activation, signaling and aggregation PRKCA Gene Information Basic Information Ensembl ID: ENSG00000154229 Description: protein kinase C alpha [Source:HGNC Symbol;Acc:HGNC:9393] Location: 17:66302613-66810743 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: bipolar cell Other: Transmission across Chemical Synapses Integration of energy metabolism Signaling by WNT TGFB1 Gene Information Basic Information Ensembl ID: ENSG00000105329 Description: transforming growth factor beta 1 [Source:HGNC Symbol;Acc:HGNC:11766] Location: 19:41301587-41353922 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell developing T cell T cell CD8+ T cell platelet Specialized T cell megakaryocyte Other: Platelet activation, signaling and aggregation RNA Polymerase II Transcription Cytokine Signaling in Immune system THBS1 Gene Information Basic Information Ensembl ID: ENSG00000137801 Description: thrombospondin 1 [Source:HGNC Symbol;Acc:HGNC:11785] Location: 15:39581079-39599466 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell epithelial cell macrophage fibroblast phagocyte stromal cell smooth muscle cell monocyte neutrophil megakaryocyte pericyte Other: Diseases of glycosylation Integrin cell surface interactions Non-integrin membrane-ECM interactions
Peptide hormone metabolism Pathway Hierarchies & Genes Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (2 genes) Metabolism of proteins Peptide hormone metabolism Incretin synthesis, secretion, and inactivation Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 2 genes Metabolism of Angiotensinogen to Angiotensins (2 genes) Metabolism of proteins Peptide hormone metabolism Metabolism of Angiotensinogen to Angiotensins 2 genes	CPA3 Gene Information Basic Information Ensembl ID: ENSG00000163751 Description: carboxypeptidase A3 [Source:HGNC Symbol;Acc:HGNC:2298] Location: 3:148865296-148897203 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell mast cell hematopoietic stem cell Other: Peptide hormone metabolism CTNNB1 Gene Information Basic Information Ensembl ID: ENSG00000168036 Description: catenin beta 1 [Source:HGNC Symbol;Acc:HGNC:2514] Location: 3:41194741-41260096 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell endothelial cell epithelial cell stem cell phagocyte adrenal cortical cell fibroblast monocyte Specialized T cell melanocyte M cell Other: Apoptosis Innate Immune System Signaling by WNT DPP4 Gene Information Basic Information Ensembl ID: ENSG00000197635 Description: dipeptidyl peptidase 4 [Source:HGNC Symbol;Acc:HGNC:3009] Location: 2:161992245-162074394 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endocrine cell trophoblast cell developing T cell Other: Peptide hormone metabolism GZMH Gene Information Basic Information Ensembl ID: ENSG00000100450 Description: granzyme H [Source:HGNC Symbol;Acc:HGNC:4710] Location: 14:24606480-24609699 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell CD8+ T cell memory T cell developing T cell T cell Specialized T cell lymphocyte Cytotoxic Other: Peptide hormone metabolism Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Peroxisomal protein import Pathway Hierarchies & Genes Peroxisomal protein import (2 genes) Protein localization Peroxisomal protein import 2 genes	IDH1 Gene Information Basic Information Ensembl ID: ENSG00000138413 Description: isocitrate dehydrogenase (NADP(+)) 1 [Source:HGNC Symbol;Acc:HGNC:5382] Location: 2:208236229-208266074 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Innate Immune System Metabolism of vitamins and cofactors Cellular responses to stress NOS2 Gene Information Basic Information Ensembl ID: ENSG00000007171 Description: nitric oxide synthase 2 [Source:HGNC Symbol;Acc:HGNC:7873] Location: 17:27756766-27800529 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Innate Immune System Platelet homeostasis
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes Pathway Hierarchies & Genes Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes (2 genes) Circadian clock Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes 2 genes	CREBBP Gene Information Basic Information Ensembl ID: ENSG00000005339 Description: CREB binding protein [Source:HGNC Symbol;Acc:HGNC:2348] Location: 16:3725054-3880713 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes BMAL1:CLOCK,NPAS2 activates circadian expression RORC Gene Information Basic Information Ensembl ID: ENSG00000143365 Description: RAR related orphan receptor C [Source:HGNC Symbol;Acc:HGNC:10260] Location: 1:151806071-151831845 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: CD4+ T cell T cell innate lymphoid cell Specialized T cell Other: Cytokine Signaling in Immune system RNA Polymerase II Transcription Expression of BMAL (ARNTL), CLOCK, and NPAS2
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters Pathway Hierarchies & Genes Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters (1 genes) Circadian clock Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 1 genes	CREBBP Gene Information Basic Information Ensembl ID: ENSG00000005339 Description: CREB binding protein [Source:HGNC Symbol;Acc:HGNC:2348] Location: 16:3725054-3880713 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes BMAL1:CLOCK,NPAS2 activates circadian expression
Platelet Adhesion to exposed collagen Pathway Hierarchies & Genes Platelet Adhesion to exposed collagen (5 genes) Hemostasis Platelet Adhesion to exposed collagen 5 genes	FYN Gene Information Basic Information Ensembl ID: ENSG00000010810 Description: FYN proto-oncogene%2C Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:4037] Location: 6:111660332-111873452 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Cellular responses to mechanical stimuli ITGA1 Gene Information Basic Information Ensembl ID: ENSG00000213949 Description: integrin subunit alpha 1 [Source:HGNC Symbol;Acc:HGNC:6134] Location: 5:52787916-52959209 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell pericyte developing T cell epithelial cell fibroblast glial cell stromal cell Specialized T cell smooth muscle cell CD8+ T cell T cell mesenchymal cell lymphocyte beta cell memory T cell Other: Integrin cell surface interactions Laminin interactions Smooth Muscle Contraction ITGA2 Gene Information Basic Information Ensembl ID: ENSG00000164171 Description: integrin subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:6137] Location: 5:52989340-53094779 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell stem cell pancreatic cell goblet cell Other: Integrin cell surface interactions Laminin interactions Non-integrin membrane-ECM interactions ITGB1 Gene Information Basic Information Ensembl ID: ENSG00000150093 Description: integrin subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:6153] Location: 10:32887273-33005792 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stellate cell pericyte trophoblast cell epithelial cell stromal cell stem cell endothelial cell smooth muscle cell fibroblast mesenchymal stem cell Other: Laminin interactions Cell surface interactions at the vascular wall Cytokine Signaling in Immune system LYN Gene Information Basic Information Ensembl ID: ENSG00000254087 Description: LYN proto-oncogene%2C Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6735] Location: 8:55879835-56014169 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System
Platelet activation, signaling and aggregation Pathway Hierarchies & Genes Platelet Aggregation (Plug Formation) (15 genes) Hemostasis Platelet activation, signaling and aggregation Response to elevated platelet cytosolic Ca2+ Platelet degranulation 13 genes Platelet Aggregation (Plug Formation) 2 genes ADP signalling through P2Y purinoceptor 1 (1 genes) Hemostasis Platelet activation, signaling and aggregation Signal amplification ADP signalling through P2Y purinoceptor 1 1 genes Disinhibition of SNARE formation (1 genes) Hemostasis Platelet activation, signaling and aggregation Response to elevated platelet cytosolic Ca2+ Disinhibition of SNARE formation 1 genes Platelet Aggregation (Plug Formation) (7 genes) Hemostasis Platelet activation, signaling and aggregation GPVI-mediated activation cascade 6 genes Platelet Aggregation (Plug Formation) 1 genes Platelet Aggregation (Plug Formation) (1 genes) Hemostasis Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation) 1 genes Thrombin signalling through proteinase activated receptors (PARs) (2 genes) Hemostasis Platelet activation, signaling and aggregation Thrombin signalling through proteinase activated receptors (PARs) 2 genes	AKT1 Gene Information Basic Information Ensembl ID: ENSG00000142208 Description: AKT serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:391] Location: 14:104769349-104795759 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Integrin signaling Apoptosis Cytokine Signaling in Immune system CTSW Gene Information Basic Information Ensembl ID: ENSG00000172543 Description: cathepsin W [Source:HGNC Symbol;Acc:HGNC:2546] Location: 11:65879809-65883741 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell CD8+ T cell developing T cell T cell memory T cell Other: Platelet activation, signaling and aggregation EGF Gene Information Basic Information Ensembl ID: ENSG00000138798 Description: epidermal growth factor [Source:HGNC Symbol;Acc:HGNC:3229] Location: 4:109912883-110013766 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: skeletal muscle cell epithelial cell glial cell Other: Signaling by NOTCH Membrane Trafficking Cellular responses to stress FN1 Gene Information Basic Information Ensembl ID: ENSG00000115414 Description: fibronectin 1 [Source:HGNC Symbol;Acc:HGNC:3778] Location: 2:215360440-215436073 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell fibroblast endocrine cell pericyte epithelial cell stellate cell stem cell phagocyte muscle cell stromal cell smooth muscle cell thymic epithelial cell skeletal muscle cell mesenchymal cell Other: Cytokine Signaling in Immune system Degradation of the extracellular matrix Elastic fibre formation FYN Gene Information Basic Information Ensembl ID: ENSG00000010810 Description: FYN proto-oncogene%2C Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:4037] Location: 6:111660332-111873452 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Cellular responses to mechanical stimuli HGF Gene Information Basic Information Ensembl ID: ENSG00000019991 Description: hepatocyte growth factor [Source:HGNC Symbol;Acc:HGNC:4893] Location: 7:81699010-81770438 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stellate cell fibroblast stromal cell bone cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades Platelet activation, signaling and aggregation ITGB3 Gene Information Basic Information Ensembl ID: ENSG00000259207 Description: integrin subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:6156] Location: 17:47253827-47313743 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: platelet epithelial cell monocyte Other: ECM proteoglycans Elastic fibre formation Cell surface interactions at the vascular wall LCK Gene Information Basic Information Ensembl ID: ENSG00000182866 Description: LCK proto-oncogene%2C Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6524] Location: 1:32251244-32286165 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell CD8+ T cell developing T cell T cell lymphocyte Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System LYN Gene Information Basic Information Ensembl ID: ENSG00000254087 Description: LYN proto-oncogene%2C Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6735] Location: 8:55879835-56014169 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System MAPK1 Gene Information Basic Information Ensembl ID: ENSG00000100030 Description: mitogen-activated protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:6871] Location: 22:21759657-21867680 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Transmission across Chemical Synapses Signaling by NODAL MAPK14 Gene Information Basic Information Ensembl ID: ENSG00000112062 Description: mitogen-activated protein kinase 14 [Source:HGNC Symbol;Acc:HGNC:6876] Location: 6:36027752-36122511 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Platelet homeostasis Cytokine Signaling in Immune system Mitochondrial biogenesis MAPK3 Gene Information Basic Information Ensembl ID: ENSG00000102882 Description: mitogen-activated protein kinase 3 [Source:HGNC Symbol;Acc:HGNC:6877] Location: 16:30114105-30123506 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Transmission across Chemical Synapses Signaling by NODAL PDGFA Gene Information Basic Information Ensembl ID: ENSG00000197461 Description: platelet derived growth factor subunit A [Source:HGNC Symbol;Acc:HGNC:8799] Location: 7:497258-520296 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte smooth muscle cell Specialized T cell secretory cell Other: Cellular responses to stress Non-integrin membrane-ECM interactions MAPK family signaling cascades PDGFB Gene Information Basic Information Ensembl ID: ENSG00000100311 Description: platelet derived growth factor subunit B [Source:HGNC Symbol;Acc:HGNC:8800] Location: 22:39223359-39244982 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell Other: Non-integrin membrane-ECM interactions MAPK family signaling cascades Platelet activation, signaling and aggregation PECAM1 Gene Information Basic Information Ensembl ID: ENSG00000261371 Description: platelet and endothelial cell adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:8823] Location: 17:64319415-64413776 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell neuron fibroblast monocyte pericyte smooth muscle cell endocrine cell epithelial cell platelet immune cell stromal cell hematopoietic stem cell lymphocyte mesenchymal stem cell endocardial cell Other: Innate Immune System Cell surface interactions at the vascular wall Integrin cell surface interactions PIK3CA Gene Information Basic Information Ensembl ID: ENSG00000121879 Description: phosphatidylinositol-4%2C5-bisphosphate 3-kinase catalytic subunit alpha [Source:HGNC Symbol;Acc:HGNC:8975] Location: 3:179148114-179240093 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System PIK3CG Gene Information Basic Information Ensembl ID: ENSG00000105851 Description: phosphatidylinositol-4%2C5-bisphosphate 3-kinase catalytic subunit gamma [Source:HGNC Symbol;Acc:HGNC:8978] Location: 7:106865278-106908980 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: tuft cell Other: Adaptive Immune System Signaling by GPCR Metabolism of lipids PRKCA Gene Information Basic Information Ensembl ID: ENSG00000154229 Description: protein kinase C alpha [Source:HGNC Symbol;Acc:HGNC:9393] Location: 17:66302613-66810743 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: bipolar cell Other: Transmission across Chemical Synapses Integration of energy metabolism Signaling by WNT PTPN11 Gene Information Basic Information Ensembl ID: ENSG00000179295 Description: protein tyrosine phosphatase non-receptor type 11 [Source:HGNC Symbol;Acc:HGNC:9644] Location: 12:112418351-112509918 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System SYK Gene Information Basic Information Ensembl ID: ENSG00000165025 Description: spleen associated tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:11491] Location: 9:90801787-90898549 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell phagocyte microglia Follicular B cell myeloid cell antigen presenting cell hematopoietic cell dendritic cell macrophage Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System TGFB1 Gene Information Basic Information Ensembl ID: ENSG00000105329 Description: transforming growth factor beta 1 [Source:HGNC Symbol;Acc:HGNC:11766] Location: 19:41301587-41353922 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell developing T cell T cell CD8+ T cell platelet Specialized T cell megakaryocyte Other: Platelet activation, signaling and aggregation RNA Polymerase II Transcription Cytokine Signaling in Immune system TGFB2 Gene Information Basic Information Ensembl ID: ENSG00000092969 Description: transforming growth factor beta 2 [Source:HGNC Symbol;Acc:HGNC:11768] Location: 1:218345336-218444619 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell Other: Elastic fibre formation ECM proteoglycans Platelet activation, signaling and aggregation TGFB3 Gene Information Basic Information Ensembl ID: ENSG00000119699 Description: transforming growth factor beta 3 [Source:HGNC Symbol;Acc:HGNC:11769] Location: 14:75958097-75983011 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte fibroblast Other: Elastic fibre formation ECM proteoglycans Platelet activation, signaling and aggregation THBS1 Gene Information Basic Information Ensembl ID: ENSG00000137801 Description: thrombospondin 1 [Source:HGNC Symbol;Acc:HGNC:11785] Location: 15:39581079-39599466 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell epithelial cell macrophage fibroblast phagocyte stromal cell smooth muscle cell monocyte neutrophil megakaryocyte pericyte Other: Diseases of glycosylation Integrin cell surface interactions Non-integrin membrane-ECM interactions VEGFA Gene Information Basic Information Ensembl ID: ENSG00000112715 Description: vascular endothelial growth factor A [Source:HGNC Symbol;Acc:HGNC:12680] Location: 6:43770184-43786487 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell macrophage epithelial cell stem cell monocyte fibroblast microglia pancreatic cell granulocyte secretory cell astrocyte dendritic cell endothelial cell Other: Cytokine Signaling in Immune system Cellular responses to stress RNA Polymerase II Transcription VEGFB Gene Information Basic Information Ensembl ID: ENSG00000173511 Description: vascular endothelial growth factor B [Source:HGNC Symbol;Acc:HGNC:12681] Location: 11:64234584-64239264 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endocrine cell dendritic cell fibroblast antigen presenting cell Other: Platelet activation, signaling and aggregation Signaling by Receptor Tyrosine Kinases VEGFC Gene Information Basic Information Ensembl ID: ENSG00000150630 Description: vascular endothelial growth factor C [Source:HGNC Symbol;Acc:HGNC:12682] Location: 4:176683538-176792922 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell smooth muscle cell lymphocyte Other: Platelet activation, signaling and aggregation Signaling by Receptor Tyrosine Kinases
Platelet homeostasis Pathway Hierarchies & Genes Nitric oxide stimulates guanylate cyclase (1 genes) Hemostasis Platelet homeostasis Nitric oxide stimulates guanylate cyclase 1 genes Platelet sensitization by LDL (1 genes) Hemostasis Platelet homeostasis Platelet sensitization by LDL 1 genes Platelet sensitization by LDL (2 genes) Hemostasis Platelet homeostasis Platelet sensitization by LDL 2 genes	MAPK14 Gene Information Basic Information Ensembl ID: ENSG00000112062 Description: mitogen-activated protein kinase 14 [Source:HGNC Symbol;Acc:HGNC:6876] Location: 6:36027752-36122511 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Platelet homeostasis Cytokine Signaling in Immune system Mitochondrial biogenesis NOS2 Gene Information Basic Information Ensembl ID: ENSG00000007171 Description: nitric oxide synthase 2 [Source:HGNC Symbol;Acc:HGNC:7873] Location: 17:27756766-27800529 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Innate Immune System Platelet homeostasis PECAM1 Gene Information Basic Information Ensembl ID: ENSG00000261371 Description: platelet and endothelial cell adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:8823] Location: 17:64319415-64413776 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell neuron fibroblast monocyte pericyte smooth muscle cell endocrine cell epithelial cell platelet immune cell stromal cell hematopoietic stem cell lymphocyte mesenchymal stem cell endocardial cell Other: Innate Immune System Cell surface interactions at the vascular wall Integrin cell surface interactions PTPN11 Gene Information Basic Information Ensembl ID: ENSG00000179295 Description: protein tyrosine phosphatase non-receptor type 11 [Source:HGNC Symbol;Acc:HGNC:9644] Location: 12:112418351-112509918 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System
Post-translational protein modification Pathway Hierarchies & Genes Neddylation (2 genes) Metabolism of proteins Post-translational protein modification SUMOylation SUMO E3 ligases SUMOylate target proteins SUMOylation of DNA damage response and repair proteins 1 genes Deubiquitination Metalloprotease DUBs Neddylation 1 genes Ovarian tumor domain proteases (4 genes) Metabolism of proteins Post-translational protein modification SUMOylation SUMO E3 ligases SUMOylate target proteins SUMOylation of intracellular receptors 2 genes Deubiquitination Ovarian tumor domain proteases 2 genes Ub-specific processing proteases (1 genes) Metabolism of proteins Post-translational protein modification SUMOylation SUMO E3 ligases SUMOylate target proteins SUMOylation of transcription factors Deubiquitination Ub-specific processing proteases 1 genes Neddylation (1 genes) Metabolism of proteins Post-translational protein modification SUMOylation SUMO E3 ligases SUMOylate target proteins SUMOylation of DNA replication proteins Neddylation 1 genes Neddylation (9 genes) Metabolism of proteins Post-translational protein modification Deubiquitination Ub-specific processing proteases 8 genes Neddylation 1 genes SUMOylation of DNA methylation proteins (2 genes) Metabolism of proteins Post-translational protein modification SUMOylation SUMO E3 ligases SUMOylate target proteins SUMOylation of DNA methylation proteins 2 genes SUMOylation of immune response proteins (2 genes) Metabolism of proteins Post-translational protein modification SUMOylation SUMO E3 ligases SUMOylate target proteins SUMOylation of immune response proteins 2 genes SUMOylation of transcription cofactors (2 genes) Metabolism of proteins Post-translational protein modification SUMOylation SUMO E3 ligases SUMOylate target proteins SUMOylation of transcription cofactors 2 genes Termination of O-glycan biosynthesis (1 genes) Metabolism of proteins Post-translational protein modification O-linked glycosylation O-linked glycosylation of mucins Termination of O-glycan biosynthesis 1 genes Metalloprotease DUBs (1 genes) Metabolism of proteins Post-translational protein modification Deubiquitination Metalloprotease DUBs 1 genes O-glycosylation of TSR domain-containing proteins (1 genes) Metabolism of proteins Post-translational protein modification O-linked glycosylation O-glycosylation of TSR domain-containing proteins 1 genes Ovarian tumor domain proteases (1 genes) Metabolism of proteins Post-translational protein modification Deubiquitination Ovarian tumor domain proteases 1 genes UCH proteinases (3 genes) Metabolism of proteins Post-translational protein modification Deubiquitination UCH proteinases 3 genes Neddylation (2 genes) Metabolism of proteins Post-translational protein modification Neddylation 2 genes Post-translational protein phosphorylation (4 genes) Metabolism of proteins Post-translational protein modification Post-translational protein phosphorylation 4 genes Proteasome assembly (1 genes) Metabolism of proteins Post-translational protein modification Proteasome assembly 1 genes	APC Gene Information Basic Information Ensembl ID: ENSG00000134982 Description: APC regulator of WNT signaling pathway [Source:HGNC Symbol;Acc:HGNC:583] Location: 5:112707518-112846239 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: bergmann glial cell astrocyte bipolar cell Other: Apoptosis Signaling by WNT Post-translational protein modification AR Gene Information Basic Information Ensembl ID: ENSG00000169083 Description: androgen receptor [Source:HGNC Symbol;Acc:HGNC:644] Location: X:67544021-67730619 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: fibroblast stromal cell epithelial cell adipocyte Other: Cellular responses to stress Post-translational protein modification RNA Polymerase II Transcription BIRC5 Gene Information Basic Information Ensembl ID: ENSG00000089685 Description: baculoviral IAP repeat containing 5 [Source:HGNC Symbol;Acc:HGNC:593] Location: 17:78214186-78225636 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell glial cell epithelial cell erythroid lineage cell progenitor cell cancer stem cell proliferative cell Other: Cytokine Signaling in Immune system Post-translational protein modification Cell Cycle, Mitotic BMI1 Gene Information Basic Information Ensembl ID: ENSG00000168283 Description: BMI1 proto-oncogene%2C polycomb ring finger [Source:HGNC Symbol;Acc:HGNC:1066] Location: 10:22321099-22331484 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cellular responses to stress Post-translational protein modification RNA Polymerase II Transcription BRCA1 Gene Information Basic Information Ensembl ID: ENSG00000012048 Description: BRCA1 DNA repair associated [Source:HGNC Symbol;Acc:HGNC:1100] Location: 17:43044295-43170245 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: cancer cell Other: Meiosis Cellular responses to stress DNA Double-Strand Break Repair CDKN1A Gene Information Basic Information Ensembl ID: ENSG00000124762 Description: cyclin dependent kinase inhibitor 1A [Source:HGNC Symbol;Acc:HGNC:1784] Location: 6:36676460-36687397 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell pericyte dendritic cell smooth muscle cell fibroblast muscle cell monocyte Other: Cytokine Signaling in Immune system Cellular responses to stress Post-translational protein modification CREBBP Gene Information Basic Information Ensembl ID: ENSG00000005339 Description: CREB binding protein [Source:HGNC Symbol;Acc:HGNC:2348] Location: 16:3725054-3880713 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes BMAL1:CLOCK,NPAS2 activates circadian expression CSF1 Gene Information Basic Information Ensembl ID: ENSG00000184371 Description: colony stimulating factor 1 [Source:HGNC Symbol;Acc:HGNC:2432] Location: 1:109910242-109930992 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell stromal cell mast cell microglia Other: MITF-M-regulated melanocyte development Cytokine Signaling in Immune system Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) CYLD Gene Information Basic Information Ensembl ID: ENSG00000083799 Description: CYLD lysine 63 deubiquitinase [Source:HGNC Symbol;Acc:HGNC:2584] Location: 16:50742050-50801935 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell developing T cell Specialized T cell Regulatory T cell Other: Innate Immune System Post-translational protein modification Death Receptor Signaling DNMT1 Gene Information Basic Information Ensembl ID: ENSG00000130816 Description: DNA methyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:2976] Location: 19:10133342-10231286 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell lymphoid progenitor cell Follicular B cell Other: Epigenetic regulation of gene expression Post-translational protein modification Signaling by Receptor Tyrosine Kinases DNMT3A Gene Information Basic Information Ensembl ID: ENSG00000119772 Description: DNA methyltransferase 3 alpha [Source:HGNC Symbol;Acc:HGNC:2978] Location: 2:25227855-25342590 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Defective pyroptosis Epigenetic regulation of gene expression Chromatin modifying enzymes ESR1 Gene Information Basic Information Ensembl ID: ENSG00000091831 Description: estrogen receptor 1 [Source:HGNC Symbol;Acc:HGNC:3467] Location: 6:151656691-152129619 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: fibroblast stromal cell plasma cell Other: Cellular responses to stress Post-translational protein modification RNA Polymerase II Transcription FN1 Gene Information Basic Information Ensembl ID: ENSG00000115414 Description: fibronectin 1 [Source:HGNC Symbol;Acc:HGNC:3778] Location: 2:215360440-215436073 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell fibroblast endocrine cell pericyte epithelial cell stellate cell stem cell phagocyte muscle cell stromal cell smooth muscle cell thymic epithelial cell skeletal muscle cell mesenchymal cell Other: Cytokine Signaling in Immune system Degradation of the extracellular matrix Elastic fibre formation GATA3 Gene Information Basic Information Ensembl ID: ENSG00000107485 Description: GATA binding protein 3 [Source:HGNC Symbol;Acc:HGNC:4172] Location: 10:8045378-8075198 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell epithelial cell trophoblast cell developing T cell Regulatory T cell phagocyte natural killer cell CD4+ T cell lymphocyte innate lymphoid cell T helper cell neuron Other: Cytokine Signaling in Immune system Post-translational protein modification RNA Polymerase II Transcription HIF1A Gene Information Basic Information Ensembl ID: ENSG00000100644 Description: hypoxia inducible factor 1 subunit alpha [Source:HGNC Symbol;Acc:HGNC:4910] Location: 14:61695513-61748259 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell macrophage phagocyte microglia granulocyte monocyte myeloid cell antigen presenting cell innate lymphoid cell dendritic cell Other: Cytokine Signaling in Immune system Signaling by NOTCH Cellular responses to stress IFIH1 Gene Information Basic Information Ensembl ID: ENSG00000115267 Description: interferon induced with helicase C domain 1 [Source:HGNC Symbol;Acc:HGNC:18873] Location: 2:162267074-162318684 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: antigen presenting cell Other: Cytokine Signaling in Immune system Innate Immune System Post-translational protein modification IL6 Gene Information Basic Information Ensembl ID: ENSG00000136244 Description: interleukin 6 [Source:HGNC Symbol;Acc:HGNC:6018] Location: 7:22725884-22732002 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte endothelial cell stromal cell smooth muscle cell CD4+ T cell vascular cell immune cell Other: Cytokine Signaling in Immune system Cellular responses to stress Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) LTBP1 Gene Information Basic Information Ensembl ID: ENSG00000049323 Description: latent transforming growth factor beta binding protein 1 [Source:HGNC Symbol;Acc:HGNC:6714] Location: 2:32946953-33399509 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell endocrine cell pericyte epithelial cell fibroblast stromal cell smooth muscle cell cardiomyocyte muscle cell platelet interstitial cell progenitor cell dendritic cell glial cell erythroblast megakaryocyte Other: Elastic fibre formation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein modification MUC1 Gene Information Basic Information Ensembl ID: ENSG00000185499 Description: mucin 1%2C cell surface associated [Source:HGNC Symbol;Acc:HGNC:7508] Location: 1:155185824-155192916 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell pneumocyte goblet cell enterocyte secretory cell cancer cell Other: Cytokine Signaling in Immune system Innate Immune System Post-translational protein modification MYC Gene Information Basic Information Ensembl ID: ENSG00000136997 Description: MYC proto-oncogene%2C bHLH transcription factor [Source:HGNC Symbol;Acc:HGNC:7553] Location: 8:127735434-127742951 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte epithelial cell fibroblast stromal cell smooth muscle cell hematopoietic progenitor cell endothelial cell stem cell erythroblast muscle cell progenitor cell transient amplifying cell cancer stem cell B cell erythroid lineage cell Other: Cytokine Signaling in Immune system Signaling by NOTCH Signaling by WNT NFKB2 Gene Information Basic Information Ensembl ID: ENSG00000077150 Description: nuclear factor kappa B subunit 2 [Source:HGNC Symbol;Acc:HGNC:7795] Location: 10:102394110-102402524 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: CD4+ T cell Other: Cytokine Signaling in Immune system Innate Immune System Chromatin modifying enzymes NLRP3 Gene Information Basic Information Ensembl ID: ENSG00000162711 Description: NLR family pyrin domain containing 3 [Source:HGNC Symbol;Acc:HGNC:16400] Location: 1:247332331-247449108 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell dendritic cell phagocyte monocyte Other: Parasitic Infection Pathways Viral Infection Pathways Innate Immune System PGR Gene Information Basic Information Ensembl ID: ENSG00000082175 Description: progesterone receptor [Source:HGNC Symbol;Acc:HGNC:8910] Location: 11:101029624-101129813 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cellular responses to stress Post-translational protein modification RNA Polymerase II Transcription PPARG Gene Information Basic Information Ensembl ID: ENSG00000132170 Description: peroxisome proliferator activated receptor gamma [Source:HGNC Symbol;Acc:HGNC:9236] Location: 3:12287368-12434356 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell pericyte epithelial cell stem cell phagocyte adipocyte macrophage tuft cell Other: Epigenetic regulation of gene expression Metabolism of lipids Post-translational protein modification PPARGC1A Gene Information Basic Information Ensembl ID: ENSG00000109819 Description: PPARG coactivator 1 alpha [Source:HGNC Symbol;Acc:HGNC:9237] Location: 4:23755041-23904089 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Mitochondrial biogenesis Epigenetic regulation of gene expression Cellular responses to stress PSMB9 Gene Information Basic Information Ensembl ID: ENSG00000240065 Description: proteasome 20S subunit beta 9 [Source:HGNC Symbol;Acc:HGNC:9546] Location: 6:32844136-32860734 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell natural killer cell CD8+ T cell memory T cell developing T cell T cell Regulatory T cell dendritic cell Other: Adaptive Immune System Post-translational protein modification RELA Gene Information Basic Information Ensembl ID: ENSG00000173039 Description: RELA proto-oncogene%2C NF-kB subunit [Source:HGNC Symbol;Acc:HGNC:9955] Location: 11:65653599-65663090 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System RIGI Gene Information Basic Information Ensembl ID: ENSG00000107201 Description: RNA sensor RIG-I [Source:HGNC Symbol;Acc:HGNC:19102] Location: 9:32455302-32526348 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Innate Immune System Post-translational protein modification SMAD2 Gene Information Basic Information Ensembl ID: ENSG00000175387 Description: SMAD family member 2 [Source:HGNC Symbol;Acc:HGNC:6768] Location: 18:47808957-47931146 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Signaling by NODAL Transcriptional regulation of pluripotent stem cells Post-translational protein modification SMAD3 Gene Information Basic Information Ensembl ID: ENSG00000166949 Description: SMAD family member 3 [Source:HGNC Symbol;Acc:HGNC:6769] Location: 15:67063763-67195173 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell stem cell mesenchymal cell Other: Signaling by NODAL Cytokine Signaling in Immune system Signaling by NOTCH SOCS3 Gene Information Basic Information Ensembl ID: ENSG00000184557 Description: suppressor of cytokine signaling 3 [Source:HGNC Symbol;Acc:HGNC:19391] Location: 17:78356778-78360077 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell pericyte fibroblast stromal cell smooth muscle cell CD4+ T cell granulocyte epithelial cell monocyte basal cell developing T cell Other: Cytokine Signaling in Immune system Adaptive Immune System Signaling by Leptin TGFB1 Gene Information Basic Information Ensembl ID: ENSG00000105329 Description: transforming growth factor beta 1 [Source:HGNC Symbol;Acc:HGNC:11766] Location: 19:41301587-41353922 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell developing T cell T cell CD8+ T cell platelet Specialized T cell megakaryocyte Other: Platelet activation, signaling and aggregation RNA Polymerase II Transcription Cytokine Signaling in Immune system TGFBR1 Gene Information Basic Information Ensembl ID: ENSG00000106799 Description: transforming growth factor beta receptor 1 [Source:HGNC Symbol;Acc:HGNC:11772] Location: 9:99104038-99154192 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: T cell phagocyte microglia Other: Post-translational protein modification Signaling by TGFB family members Signaling by TGF-beta Receptor Complex in Cancer TGFBR2 Gene Information Basic Information Ensembl ID: ENSG00000163513 Description: transforming growth factor beta receptor 2 [Source:HGNC Symbol;Acc:HGNC:11773] Location: 3:30606478-30694249 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell glial cell fibroblast Other: Post-translational protein modification Signaling by TGFB family members Signaling by TGF-beta Receptor Complex in Cancer THBS1 Gene Information Basic Information Ensembl ID: ENSG00000137801 Description: thrombospondin 1 [Source:HGNC Symbol;Acc:HGNC:11785] Location: 15:39581079-39599466 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell epithelial cell macrophage fibroblast phagocyte stromal cell smooth muscle cell monocyte neutrophil megakaryocyte pericyte Other: Diseases of glycosylation Integrin cell surface interactions Non-integrin membrane-ECM interactions TP53 Gene Information Basic Information Ensembl ID: ENSG00000141510 Description: tumor protein p53 [Source:HGNC Symbol;Acc:HGNC:11998] Location: 17:7661779-7687546 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Cytokine Signaling in Immune system Signaling by NOTCH TRAF2 Gene Information Basic Information Ensembl ID: ENSG00000127191 Description: TNF receptor associated factor 2 [Source:HGNC Symbol;Acc:HGNC:12032] Location: 9:136881912-136929221 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System
Prednisone ADME Pathway Hierarchies & Genes Prednisone ADME (1 genes) Drug ADME Prednisone ADME 1 genes	HSD11B1 Gene Information Basic Information Ensembl ID: ENSG00000117594 Description: hydroxysteroid 11-beta dehydrogenase 1 [Source:HGNC Symbol;Acc:HGNC:5208] Location: 1:209686178-209734949 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: fibroblast adipocyte Other: Metabolism of lipids Prednisone ADME
Protein folding Pathway Hierarchies & Genes Association of TriC/CCT with target proteins during biosynthesis (4 genes) Metabolism of proteins Protein folding Chaperonin-mediated protein folding Association of TriC/CCT with target proteins during biosynthesis 4 genes	CCNE1 Gene Information Basic Information Ensembl ID: ENSG00000105173 Description: cyclin E1 [Source:HGNC Symbol;Acc:HGNC:1589] Location: 19:29811991-29824312 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: trophoblast cell Other: Cellular responses to stress Protein folding Synthesis of DNA HDAC3 Gene Information Basic Information Ensembl ID: ENSG00000171720 Description: histone deacetylase 3 [Source:HGNC Symbol;Acc:HGNC:4854] Location: 5:141620876-141636849 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Death Receptor Signaling Signaling by NOTCH Mitochondrial biogenesis STAT3 Gene Information Basic Information Ensembl ID: ENSG00000168610 Description: signal transducer and activator of transcription 3 [Source:HGNC Symbol;Acc:HGNC:11364] Location: 17:42313324-42388568 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: cancer cell Other: Apoptosis Cytokine Signaling in Immune system Cellular responses to stress TP53 Gene Information Basic Information Ensembl ID: ENSG00000141510 Description: tumor protein p53 [Source:HGNC Symbol;Acc:HGNC:11998] Location: 17:7661779-7687546 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Cytokine Signaling in Immune system Signaling by NOTCH
Protein-protein interactions at synapses Pathway Hierarchies & Genes Receptor-type tyrosine-protein phosphatases (1 genes) Neuronal System Protein-protein interactions at synapses Receptor-type tyrosine-protein phosphatases 1 genes	IL1RAP Gene Information Basic Information Ensembl ID: ENSG00000196083 Description: interleukin 1 receptor accessory protein [Source:HGNC Symbol;Acc:HGNC:5995] Location: 3:190514051-190659750 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell hepatocyte sensory neuron neuron granulocyte cancer stem cell Other: Cytokine Signaling in Immune system Protein-protein interactions at synapses Intracellular signaling by second messengers
RNA Polymerase I Transcription Pathway Hierarchies & Genes RNA Polymerase I Promoter Opening (1 genes) Gene expression (Transcription) RNA Polymerase I Transcription RNA Polymerase I Promoter Clearance RNA Polymerase I Promoter Opening 1 genes	MAPK3 Gene Information Basic Information Ensembl ID: ENSG00000102882 Description: mitogen-activated protein kinase 3 [Source:HGNC Symbol;Acc:HGNC:6877] Location: 16:30114105-30123506 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Transmission across Chemical Synapses Signaling by NODAL
RNA Polymerase II Transcription Pathway Hierarchies & Genes Regulation of TP53 Degradation (7 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional Regulation by TP53 Regulation of TP53 Activity Regulation of TP53 Expression and Degradation Regulation of TP53 Degradation 7 genes Regulation of TP53 Expression (1 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional Regulation by TP53 Regulation of TP53 Activity Regulation of TP53 Expression and Degradation Regulation of TP53 Expression 1 genes RUNX2 regulates osteoblast differentiation (6 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional regulation by RUNX2 RUNX2 regulates bone development RUNX2 regulates osteoblast differentiation 6 genes Regulation of TP53 Activity through Phosphorylation (4 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional Regulation by TP53 Regulation of TP53 Activity Regulation of TP53 Activity through Phosphorylation 4 genes TP53 Regulates Transcription of Caspase Activators and Caspases (1 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional Regulation by TP53 TP53 Regulates Transcription of Cell Death Genes TP53 Regulates Transcription of Caspase Activators and Caspases 1 genes TP53 Regulates Transcription of Death Receptors and Ligands (5 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional Regulation by TP53 TP53 Regulates Transcription of Cell Death Genes TP53 Regulates Transcription of Death Receptors and Ligands 5 genes TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (2 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional Regulation by TP53 TP53 Regulates Transcription of Cell Death Genes TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 2 genes TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest (3 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional Regulation by TP53 TP53 Regulates Transcription of Cell Cycle Genes TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 3 genes TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest (2 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional Regulation by TP53 TP53 Regulates Transcription of Cell Cycle Genes TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 2 genes TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (1 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional Regulation by TP53 TP53 Regulates Transcription of Cell Death Genes TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 1 genes FOXO-mediated transcription of cell death genes (1 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway FOXO-mediated transcription FOXO-mediated transcription of cell death genes 1 genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes (1 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway FOXO-mediated transcription FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 1 genes MECP2 regulates neuronal receptors and channels (1 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional Regulation by MECP2 MECP2 regulates neuronal receptors and channels 1 genes MECP2 regulates transcription factors (1 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional Regulation by MECP2 MECP2 regulates transcription factors 1 genes RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) (6 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional regulation by RUNX1 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 6 genes RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (2 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional regulation by RUNX1 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 2 genes RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (1 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional regulation by RUNX1 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 1 genes RUNX1 regulates transcription of genes involved in BCR signaling (2 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional regulation by RUNX1 RUNX1 regulates transcription of genes involved in BCR signaling 2 genes RUNX1 regulates transcription of genes involved in differentiation of HSCs (1 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional regulation by RUNX1 RUNX1 regulates transcription of genes involved in differentiation of HSCs 1 genes RUNX1 regulates transcription of genes involved in differentiation of keratinocytes (1 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional regulation by RUNX1 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes 1 genes RUNX1 regulates transcription of genes involved in differentiation of myeloid cells (1 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional regulation by RUNX1 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells 1 genes RUNX2 regulates genes involved in cell migration (1 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional regulation by RUNX2 RUNX2 regulates genes involved in cell migration 1 genes RUNX3 Regulates Immune Response and Cell Migration (3 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional regulation by RUNX3 RUNX3 Regulates Immune Response and Cell Migration 3 genes RUNX3 regulates CDKN1A transcription (3 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional regulation by RUNX3 RUNX3 regulates CDKN1A transcription 3 genes RUNX3 regulates NOTCH signaling (2 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional regulation by RUNX3 RUNX3 regulates NOTCH signaling 2 genes RUNX3 regulates WNT signaling (3 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional regulation by RUNX3 RUNX3 regulates WNT signaling 3 genes RUNX3 regulates p14-ARF (1 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional regulation by RUNX3 RUNX3 regulates p14-ARF 1 genes Regulation of RUNX1 Expression and Activity (4 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional regulation by RUNX1 Regulation of RUNX1 Expression and Activity 4 genes Regulation of RUNX2 expression and activity (4 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional regulation by RUNX2 Regulation of RUNX2 expression and activity 4 genes TFAP2 (AP-2) family regulates transcription of cell cycle factors (1 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors TFAP2 (AP-2) family regulates transcription of cell cycle factors 1 genes TFAP2 (AP-2) family regulates transcription of growth factors and their receptors (4 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 4 genes TP53 Regulates Metabolic Genes (1 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional Regulation by TP53 TP53 Regulates Metabolic Genes 1 genes TP53 Regulates Transcription of DNA Repair Genes (2 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional Regulation by TP53 TP53 Regulates Transcription of DNA Repair Genes 2 genes Notch-HLH transcription pathway (1 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Notch-HLH transcription pathway 1 genes Nuclear Receptor transcription pathway (2 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Nuclear Receptor transcription pathway 2 genes Transcriptional Regulation by E2F6 (2 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional Regulation by E2F6 2 genes Transcriptional Regulation by MECP2 (2 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional Regulation by MECP2 2 genes Transcriptional Regulation by VENTX (4 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional Regulation by VENTX 4 genes Transcriptional regulation by RUNX2 (2 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional regulation by RUNX2 2 genes	ABL1 Gene Information Basic Information Ensembl ID: ENSG00000097007 Description: ABL proto-oncogene 1%2C non-receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:76] Location: 9:130713043-130887675 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Innate Immune System Epigenetic regulation of gene expression Myogenesis AKT1 Gene Information Basic Information Ensembl ID: ENSG00000142208 Description: AKT serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:391] Location: 14:104769349-104795759 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Integrin signaling Apoptosis Cytokine Signaling in Immune system AKT2 Gene Information Basic Information Ensembl ID: ENSG00000105221 Description: AKT serine/threonine kinase 2 [Source:HGNC Symbol;Acc:HGNC:392] Location: 19:40230317-40285536 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: T cell Other: Apoptosis Cytokine Signaling in Immune system Adaptive Immune System AKT3 Gene Information Basic Information Ensembl ID: ENSG00000117020 Description: AKT serine/threonine kinase 3 [Source:HGNC Symbol;Acc:HGNC:393] Location: 1:243488233-243851079 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell neuron epithelial cell T cell fibroblast glial cell CD8+ T cell schwann cell Specialized T cell excitatory neuron smooth muscle cell Other: Apoptosis Cytokine Signaling in Immune system Adaptive Immune System AR Gene Information Basic Information Ensembl ID: ENSG00000169083 Description: androgen receptor [Source:HGNC Symbol;Acc:HGNC:644] Location: X:67544021-67730619 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: fibroblast stromal cell epithelial cell adipocyte Other: Cellular responses to stress Post-translational protein modification RNA Polymerase II Transcription ATM Gene Information Basic Information Ensembl ID: ENSG00000149311 Description: ATM serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:795] Location: 11:108222804-108369102 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell T cell phagocyte hematopoietic cell Specialized T cell developing T cell Naive B cell lymphocyte Other: Meiosis Macroautophagy Cellular responses to stress ATR Gene Information Basic Information Ensembl ID: ENSG00000175054 Description: ATR serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:882] Location: 3:142449007-142578733 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Meiosis Cellular responses to stress DNA Double-Strand Break Repair BID Gene Information Basic Information Ensembl ID: ENSG00000015475 Description: BH3 interacting domain death agonist [Source:HGNC Symbol;Acc:HGNC:1050] Location: 22:17734138-17774770 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis RNA Polymerase II Transcription BIRC5 Gene Information Basic Information Ensembl ID: ENSG00000089685 Description: baculoviral IAP repeat containing 5 [Source:HGNC Symbol;Acc:HGNC:593] Location: 17:78214186-78225636 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell glial cell epithelial cell erythroid lineage cell progenitor cell cancer stem cell proliferative cell Other: Cytokine Signaling in Immune system Post-translational protein modification Cell Cycle, Mitotic BLK Gene Information Basic Information Ensembl ID: ENSG00000136573 Description: BLK proto-oncogene%2C Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:1057] Location: 8:11486894-11564599 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell CD4+ T cell Follicular B cell memory B cell Other: Adaptive Immune System RNA Polymerase II Transcription BMI1 Gene Information Basic Information Ensembl ID: ENSG00000168283 Description: BMI1 proto-oncogene%2C polycomb ring finger [Source:HGNC Symbol;Acc:HGNC:1066] Location: 10:22321099-22331484 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cellular responses to stress Post-translational protein modification RNA Polymerase II Transcription BMP2 Gene Information Basic Information Ensembl ID: ENSG00000125845 Description: bone morphogenetic protein 2 [Source:HGNC Symbol;Acc:HGNC:1069] Location: 20:6767686-6780246 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell osteoblast Other: Elastic fibre formation RNA Polymerase II Transcription Signaling by TGFB family members BRCA1 Gene Information Basic Information Ensembl ID: ENSG00000012048 Description: BRCA1 DNA repair associated [Source:HGNC Symbol;Acc:HGNC:1100] Location: 17:43044295-43170245 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: cancer cell Other: Meiosis Cellular responses to stress DNA Double-Strand Break Repair CASP10 Gene Information Basic Information Ensembl ID: ENSG00000003400 Description: caspase 10 [Source:HGNC Symbol;Acc:HGNC:1500] Location: 2:201182872-201229428 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: plasma cell Other: Death Receptor Signaling Innate Immune System RNA Polymerase II Transcription CCNB1 Gene Information Basic Information Ensembl ID: ENSG00000134057 Description: cyclin B1 [Source:HGNC Symbol;Acc:HGNC:1579] Location: 5:69167135-69178245 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cell Cycle, Mitotic Cell Cycle Checkpoints RNA Polymerase II Transcription CCND1 Gene Information Basic Information Ensembl ID: ENSG00000110092 Description: cyclin D1 [Source:HGNC Symbol;Acc:HGNC:1582] Location: 11:69641156-69654474 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell endothelial cell pericyte monocyte fibroblast glial cell dendritic cell pancreatic cell M cell oligodendrocyte Other: Cytokine Signaling in Immune system Signaling by NOTCH Chromatin modifying enzymes CCND3 Gene Information Basic Information Ensembl ID: ENSG00000112576 Description: cyclin D3 [Source:HGNC Symbol;Acc:HGNC:1585] Location: 6:41934934-42050357 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell natural killer cell developing T cell epithelial cell CD4+ T cell lymphoid progenitor cell T cell hematopoietic cell Specialized T cell memory T cell lymphocyte megakaryocyte Other: MAPK family signaling cascades Cell Cycle, Mitotic RNA Polymerase II Transcription CCNE1 Gene Information Basic Information Ensembl ID: ENSG00000105173 Description: cyclin E1 [Source:HGNC Symbol;Acc:HGNC:1589] Location: 19:29811991-29824312 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: trophoblast cell Other: Cellular responses to stress Protein folding Synthesis of DNA CDC25C Gene Information Basic Information Ensembl ID: ENSG00000158402 Description: cell division cycle 25C [Source:HGNC Symbol;Acc:HGNC:1727] Location: 5:138285269-138338355 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cell Cycle, Mitotic Cell Cycle Checkpoints RNA Polymerase II Transcription CDK2 Gene Information Basic Information Ensembl ID: ENSG00000123374 Description: cyclin dependent kinase 2 [Source:HGNC Symbol;Acc:HGNC:1771] Location: 12:55966781-55972789 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Meiosis Cellular responses to stress DNA Double-Strand Break Repair CDK4 Gene Information Basic Information Ensembl ID: ENSG00000135446 Description: cyclin dependent kinase 4 [Source:HGNC Symbol;Acc:HGNC:1773] Location: 12:57747727-57756013 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: T cell schwann cell progenitor cell neural crest cell Other: Adipogenesis Meiosis Cellular responses to stress CDK6 Gene Information Basic Information Ensembl ID: ENSG00000105810 Description: cyclin dependent kinase 6 [Source:HGNC Symbol;Acc:HGNC:1777] Location: 7:92604921-92836573 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell skeletal muscle cell hematopoietic stem cell fibroblast lymphoid progenitor cell progenitor cell mesangial cell megakaryocyte hematopoietic progenitor cell Other: Cellular responses to stress Cell Cycle, Mitotic RNA Polymerase II Transcription CDKN1A Gene Information Basic Information Ensembl ID: ENSG00000124762 Description: cyclin dependent kinase inhibitor 1A [Source:HGNC Symbol;Acc:HGNC:1784] Location: 6:36676460-36687397 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell pericyte dendritic cell smooth muscle cell fibroblast muscle cell monocyte Other: Cytokine Signaling in Immune system Cellular responses to stress Post-translational protein modification CHEK1 Gene Information Basic Information Ensembl ID: ENSG00000149554 Description: checkpoint kinase 1 [Source:HGNC Symbol;Acc:HGNC:1925] Location: 11:125625163-125676255 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: DNA Double-Strand Break Repair Cell Cycle Checkpoints RNA Polymerase II Transcription CHEK2 Gene Information Basic Information Ensembl ID: ENSG00000183765 Description: checkpoint kinase 2 [Source:HGNC Symbol;Acc:HGNC:16627] Location: 22:28687743-28742422 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: DNA Double-Strand Break Repair Cell Cycle Checkpoints RNA Polymerase II Transcription CREBBP Gene Information Basic Information Ensembl ID: ENSG00000005339 Description: CREB binding protein [Source:HGNC Symbol;Acc:HGNC:2348] Location: 16:3725054-3880713 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes BMAL1:CLOCK,NPAS2 activates circadian expression CSF1R Gene Information Basic Information Ensembl ID: ENSG00000182578 Description: colony stimulating factor 1 receptor [Source:HGNC Symbol;Acc:HGNC:2433] Location: 5:150053291-150113372 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron dendritic cell macrophage phagocyte monocyte antigen presenting cell hematopoietic cell microglia Macrophage-dendritic cell progenitor Other: Cytokine Signaling in Immune system RNA Polymerase II Transcription CSF2 Gene Information Basic Information Ensembl ID: ENSG00000164400 Description: colony stimulating factor 2 [Source:HGNC Symbol;Acc:HGNC:2434] Location: 5:132073789-132076170 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system MAPK family signaling cascades RNA Polymerase II Transcription CTLA4 Gene Information Basic Information Ensembl ID: ENSG00000163599 Description: cytotoxic T-lymphocyte associated protein 4 [Source:HGNC Symbol;Acc:HGNC:2505] Location: 2:203853888-203873965 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: developing T cell Regulatory T cell CD4+ T cell CD8+ T cell immune cell Other: Adaptive Immune System RNA Polymerase II Transcription CTNNB1 Gene Information Basic Information Ensembl ID: ENSG00000168036 Description: catenin beta 1 [Source:HGNC Symbol;Acc:HGNC:2514] Location: 3:41194741-41260096 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell endothelial cell epithelial cell stem cell phagocyte adrenal cortical cell fibroblast monocyte Specialized T cell melanocyte M cell Other: Apoptosis Innate Immune System Signaling by WNT E2F1 Gene Information Basic Information Ensembl ID: ENSG00000101412 Description: E2F transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:3113] Location: 20:33675477-33686385 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Signaling by NOTCH Cellular responses to stress EGFR Gene Information Basic Information Ensembl ID: ENSG00000146648 Description: epidermal growth factor receptor [Source:HGNC Symbol;Acc:HGNC:3236] Location: 7:55019017-55211628 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell endothelial cell trophoblast cell hepatocyte stem cell adipocyte fibroblast muscle cell stromal cell mesenchymal stem cell skeletal muscle cell cancer cell Other: Signaling by NOTCH Membrane Trafficking Signaling by GPCR ESR1 Gene Information Basic Information Ensembl ID: ENSG00000091831 Description: estrogen receptor 1 [Source:HGNC Symbol;Acc:HGNC:3467] Location: 6:151656691-152129619 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: fibroblast stromal cell plasma cell Other: Cellular responses to stress Post-translational protein modification RNA Polymerase II Transcription EZH2 Gene Information Basic Information Ensembl ID: ENSG00000106462 Description: enhancer of zeste 2 polycomb repressive complex 2 subunit [Source:HGNC Symbol;Acc:HGNC:3527] Location: 7:148807257-148884321 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell Other: Epigenetic regulation of gene expression Cellular responses to stress Chromatin modifying enzymes FAS Gene Information Basic Information Ensembl ID: ENSG00000026103 Description: Fas cell surface death receptor [Source:HGNC Symbol;Acc:HGNC:11920] Location: 10:88953813-89029605 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: CD4+ T cell Regulatory T cell Other: Apoptosis Regulated Necrosis RNA Polymerase II Transcription FASLG Gene Information Basic Information Ensembl ID: ENSG00000117560 Description: Fas ligand [Source:HGNC Symbol;Acc:HGNC:11936] Location: 1:172659103-172666876 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell T cell Specialized T cell CD8+ T cell Other: Apoptosis Cytokine Signaling in Immune system Regulated Necrosis FOXP3 Gene Information Basic Information Ensembl ID: ENSG00000049768 Description: forkhead box P3 [Source:HGNC Symbol;Acc:HGNC:6106] Location: X:49250438-49264800 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Regulatory T cell CD4+ T cell immune cell myeloid derived suppressor cell CD8+ T cell T cell Other: RNA Polymerase II Transcription G6PD Gene Information Basic Information Ensembl ID: ENSG00000160211 Description: glucose-6-phosphate dehydrogenase [Source:HGNC Symbol;Acc:HGNC:4057] Location: X:154517825-154547572 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Specialized T cell natural killer cell Other: Cellular responses to stress Metabolism of carbohydrates and carbohydrate derivatives RNA Polymerase II Transcription GATA3 Gene Information Basic Information Ensembl ID: ENSG00000107485 Description: GATA binding protein 3 [Source:HGNC Symbol;Acc:HGNC:4172] Location: 10:8045378-8075198 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell epithelial cell trophoblast cell developing T cell Regulatory T cell phagocyte natural killer cell CD4+ T cell lymphocyte innate lymphoid cell T helper cell neuron Other: Cytokine Signaling in Immune system Post-translational protein modification RNA Polymerase II Transcription HDAC3 Gene Information Basic Information Ensembl ID: ENSG00000171720 Description: histone deacetylase 3 [Source:HGNC Symbol;Acc:HGNC:4854] Location: 5:141620876-141636849 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Death Receptor Signaling Signaling by NOTCH Mitochondrial biogenesis IFNG Gene Information Basic Information Ensembl ID: ENSG00000111537 Description: interferon gamma [Source:HGNC Symbol;Acc:HGNC:5438] Location: 12:68154768-68159740 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell memory T cell T cell Specialized T cell CD8+ T cell developing T cell Other: Cytokine Signaling in Immune system RNA Polymerase II Transcription IL2 Gene Information Basic Information Ensembl ID: ENSG00000109471 Description: interleukin 2 [Source:HGNC Symbol;Acc:HGNC:6001] Location: 4:122451470-122456725 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: CD4+ T cell innate lymphoid cell CD8+ T cell developing T cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades RNA Polymerase II Transcription IL2RA Gene Information Basic Information Ensembl ID: ENSG00000134460 Description: interleukin 2 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:6008] Location: 10:6010689-6062370 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Regulatory T cell macrophage dendritic cell developing T cell B cell mast cell CD8+ T cell T cell Follicular B cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades RNA Polymerase II Transcription IL6 Gene Information Basic Information Ensembl ID: ENSG00000136244 Description: interleukin 6 [Source:HGNC Symbol;Acc:HGNC:6018] Location: 7:22725884-22732002 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte endothelial cell stromal cell smooth muscle cell CD4+ T cell vascular cell immune cell Other: Cytokine Signaling in Immune system Cellular responses to stress Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) IRAK1 Gene Information Basic Information Ensembl ID: ENSG00000184216 Description: interleukin 1 receptor associated kinase 1 [Source:HGNC Symbol;Acc:HGNC:6112] Location: X:154010506-154019902 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: monocyte Other: Cytokine Signaling in Immune system Innate Immune System RNA Polymerase II Transcription ITGA4 Gene Information Basic Information Ensembl ID: ENSG00000115232 Description: integrin subunit alpha 4 [Source:HGNC Symbol;Acc:HGNC:6140] Location: 2:181457202-181538940 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell developing T cell Naive B cell Specialized T cell mast cell lymphoid progenitor cell CD8+ T cell erythroid lineage cell T cell memory T cell progenitor cell erythroblast projection neuron Other: Cell surface interactions at the vascular wall Integrin cell surface interactions Adaptive Immune System ITGA5 Gene Information Basic Information Ensembl ID: ENSG00000161638 Description: integrin subunit alpha 5 [Source:HGNC Symbol;Acc:HGNC:6141] Location: 12:54395261-54419266 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell epithelial cell stromal cell smooth muscle cell trophoblast cell mesenchymal stem cell fibroblast Other: Elastic fibre formation Fibronectin matrix formation Cell surface interactions at the vascular wall ITGAL Gene Information Basic Information Ensembl ID: ENSG00000005844 Description: integrin subunit alpha L [Source:HGNC Symbol;Acc:HGNC:6148] Location: 16:30472658-30523567 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell developing T cell T cell Specialized T cell CD4+ T cell lymphoid progenitor cell CD8+ T cell natural killer cell innate lymphoid cell leukocyte monocyte Other: Adaptive Immune System Innate Immune System Cell surface interactions at the vascular wall JAG1 Gene Information Basic Information Ensembl ID: ENSG00000101384 Description: jagged canonical Notch ligand 1 [Source:HGNC Symbol;Acc:HGNC:6188] Location: 20:10637684-10673999 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell pericyte smooth muscle cell mural cell Other: Signaling by NOTCH RNA Polymerase II Transcription Signaling by Rho GTPases, Miro GTPases and RHOBTB3 KIT Gene Information Basic Information Ensembl ID: ENSG00000157404 Description: KIT proto-oncogene%2C receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6342] Location: 4:54657267-54740783 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell intercalated cell tuft cell brush cell mast cell progenitor cell stem cell melanocyte Specialized T cell hematopoietic progenitor cell hematopoietic cell cancer stem cell stromal cell interstitial cell Other: MAPK family signaling cascades RNA Polymerase II Transcription Intracellular signaling by second messengers KRAS Gene Information Basic Information Ensembl ID: ENSG00000133703 Description: KRAS proto-oncogene%2C GTPase [Source:HGNC Symbol;Acc:HGNC:6407] Location: 12:25205246-25250936 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Signaling by Non-Receptor Tyrosine Kinases Transmission across Chemical Synapses Cytokine Signaling in Immune system LEF1 Gene Information Basic Information Ensembl ID: ENSG00000138795 Description: lymphoid enhancer binding factor 1 [Source:HGNC Symbol;Acc:HGNC:6551] Location: 4:108047545-108168956 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell developing T cell T cell Regulatory T cell Naive B cell CD4+ T cell lymphoid progenitor cell innate lymphoid cell Other: Signaling by WNT RNA Polymerase II Transcription Transcriptional regulation of granulopoiesis MAPK1 Gene Information Basic Information Ensembl ID: ENSG00000100030 Description: mitogen-activated protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:6871] Location: 22:21759657-21867680 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Transmission across Chemical Synapses Signaling by NODAL MAPK14 Gene Information Basic Information Ensembl ID: ENSG00000112062 Description: mitogen-activated protein kinase 14 [Source:HGNC Symbol;Acc:HGNC:6876] Location: 6:36027752-36122511 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Platelet homeostasis Cytokine Signaling in Immune system Mitochondrial biogenesis MAPK3 Gene Information Basic Information Ensembl ID: ENSG00000102882 Description: mitogen-activated protein kinase 3 [Source:HGNC Symbol;Acc:HGNC:6877] Location: 16:30114105-30123506 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Transmission across Chemical Synapses Signaling by NODAL MET Gene Information Basic Information Ensembl ID: ENSG00000105976 Description: MET proto-oncogene%2C receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:7029] Location: 7:116672196-116798377 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell pancreatic cell melanocyte Other: MAPK family signaling cascades RNA Polymerase II Transcription Intracellular signaling by second messengers MLH1 Gene Information Basic Information Ensembl ID: ENSG00000076242 Description: mutL homolog 1 [Source:HGNC Symbol;Acc:HGNC:7127] Location: 3:36993226-37050896 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Meiosis Mismatch Repair RNA Polymerase II Transcription MSH2 Gene Information Basic Information Ensembl ID: ENSG00000095002 Description: mutS homolog 2 [Source:HGNC Symbol;Acc:HGNC:7325] Location: 2:47403067-47663146 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Diseases of Mismatch Repair (MMR) Mismatch Repair RNA Polymerase II Transcription MTOR Gene Information Basic Information Ensembl ID: ENSG00000198793 Description: mechanistic target of rapamycin kinase [Source:HGNC Symbol;Acc:HGNC:3942] Location: 1:11106535-11262556 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Adaptive Immune System Macroautophagy MTOR signalling MYC Gene Information Basic Information Ensembl ID: ENSG00000136997 Description: MYC proto-oncogene%2C bHLH transcription factor [Source:HGNC Symbol;Acc:HGNC:7553] Location: 8:127735434-127742951 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte epithelial cell fibroblast stromal cell smooth muscle cell hematopoietic progenitor cell endothelial cell stem cell erythroblast muscle cell progenitor cell transient amplifying cell cancer stem cell B cell erythroid lineage cell Other: Cytokine Signaling in Immune system Signaling by NOTCH Signaling by WNT NFKB1 Gene Information Basic Information Ensembl ID: ENSG00000109320 Description: nuclear factor kappa B subunit 1 [Source:HGNC Symbol;Acc:HGNC:7794] Location: 4:102501330-102617302 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System NOTCH1 Gene Information Basic Information Ensembl ID: ENSG00000148400 Description: notch receptor 1 [Source:HGNC Symbol;Acc:HGNC:7881] Location: 9:136494433-136546048 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte T cell stem cell cancer cell Other: Signaling by NOTCH Regulation of beta-cell development Cellular responses to stress NOTCH2 Gene Information Basic Information Ensembl ID: ENSG00000134250 Description: notch receptor 2 [Source:HGNC Symbol;Acc:HGNC:7882] Location: 1:119911553-120100779 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: goblet cell Other: Signaling by NOTCH RNA Polymerase II Transcription Diseases of glycosylation NR4A1 Gene Information Basic Information Ensembl ID: ENSG00000123358 Description: nuclear receptor subfamily 4 group A member 1 [Source:HGNC Symbol;Acc:HGNC:7980] Location: 12:52022832-52059507 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: RNA Polymerase II Transcription Intracellular signaling by second messengers PI3K/AKT Signaling in Cancer PAX5 Gene Information Basic Information Ensembl ID: ENSG00000196092 Description: paired box 5 [Source:HGNC Symbol;Acc:HGNC:8619] Location: 9:36833269-37034268 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell fibroblast beta cell Other: RNA Polymerase II Transcription PGR Gene Information Basic Information Ensembl ID: ENSG00000082175 Description: progesterone receptor [Source:HGNC Symbol;Acc:HGNC:8910] Location: 11:101029624-101129813 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cellular responses to stress Post-translational protein modification RNA Polymerase II Transcription PPARG Gene Information Basic Information Ensembl ID: ENSG00000132170 Description: peroxisome proliferator activated receptor gamma [Source:HGNC Symbol;Acc:HGNC:9236] Location: 3:12287368-12434356 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell pericyte epithelial cell stem cell phagocyte adipocyte macrophage tuft cell Other: Epigenetic regulation of gene expression Metabolism of lipids Post-translational protein modification PPARGC1A Gene Information Basic Information Ensembl ID: ENSG00000109819 Description: PPARG coactivator 1 alpha [Source:HGNC Symbol;Acc:HGNC:9237] Location: 4:23755041-23904089 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Mitochondrial biogenesis Epigenetic regulation of gene expression Cellular responses to stress PTPN11 Gene Information Basic Information Ensembl ID: ENSG00000179295 Description: protein tyrosine phosphatase non-receptor type 11 [Source:HGNC Symbol;Acc:HGNC:9644] Location: 12:112418351-112509918 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System RAD51 Gene Information Basic Information Ensembl ID: ENSG00000051180 Description: RAD51 recombinase [Source:HGNC Symbol;Acc:HGNC:9817] Location: 15:40694774-40732340 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Meiosis DNA Double-Strand Break Repair RNA Polymerase II Transcription RB1 Gene Information Basic Information Ensembl ID: ENSG00000139687 Description: RB transcriptional corepressor 1 [Source:HGNC Symbol;Acc:HGNC:9884] Location: 13:48303744-48599436 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell endothelial cell microglia neuron Other: Epigenetic regulation of gene expression Cellular responses to stress Cell junction organization RELA Gene Information Basic Information Ensembl ID: ENSG00000173039 Description: RELA proto-oncogene%2C NF-kB subunit [Source:HGNC Symbol;Acc:HGNC:9955] Location: 11:65653599-65663090 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System RORC Gene Information Basic Information Ensembl ID: ENSG00000143365 Description: RAR related orphan receptor C [Source:HGNC Symbol;Acc:HGNC:10260] Location: 1:151806071-151831845 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: CD4+ T cell T cell innate lymphoid cell Specialized T cell Other: Cytokine Signaling in Immune system RNA Polymerase II Transcription Expression of BMAL (ARNTL), CLOCK, and NPAS2 RUNX3 Gene Information Basic Information Ensembl ID: ENSG00000020633 Description: RUNX family transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:10473] Location: 1:24899511-24965121 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell developing T cell Specialized T cell CD8+ T cell progenitor cell T cell lymphocyte Other: Signaling by WNT RNA Polymerase II Transcription SMAD2 Gene Information Basic Information Ensembl ID: ENSG00000175387 Description: SMAD family member 2 [Source:HGNC Symbol;Acc:HGNC:6768] Location: 18:47808957-47931146 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Signaling by NODAL Transcriptional regulation of pluripotent stem cells Post-translational protein modification SMAD3 Gene Information Basic Information Ensembl ID: ENSG00000166949 Description: SMAD family member 3 [Source:HGNC Symbol;Acc:HGNC:6769] Location: 15:67063763-67195173 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell stem cell mesenchymal cell Other: Signaling by NODAL Cytokine Signaling in Immune system Signaling by NOTCH SMARCA4 Gene Information Basic Information Ensembl ID: ENSG00000127616 Description: SWI/SNF related%2C matrix associated%2C actin dependent regulator of chromatin%2C subfamily a%2C member 4 [Source:HGNC Symbol;Acc:HGNC:11100] Location: 19:10960932-11079426 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell epithelial cell fibroblast Other: Cytokine Signaling in Immune system Signaling by WNT Epigenetic regulation of gene expression SOCS3 Gene Information Basic Information Ensembl ID: ENSG00000184557 Description: suppressor of cytokine signaling 3 [Source:HGNC Symbol;Acc:HGNC:19391] Location: 17:78356778-78360077 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell pericyte fibroblast stromal cell smooth muscle cell CD4+ T cell granulocyte epithelial cell monocyte basal cell developing T cell Other: Cytokine Signaling in Immune system Adaptive Immune System Signaling by Leptin SOX2 Gene Information Basic Information Ensembl ID: ENSG00000181449 Description: SRY-box transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:11195] Location: 3:181711925-181714436 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell pericyte progenitor cell embryonic cell fibroblast glial cell neural crest cell stem cell cancer stem cell ectodermal cell basal cell Other: Cytokine Signaling in Immune system Signaling by WNT Transcriptional regulation of pluripotent stem cells SOX9 Gene Information Basic Information Ensembl ID: ENSG00000125398 Description: SRY-box transcription factor 9 [Source:HGNC Symbol;Acc:HGNC:11204] Location: 17:72121020-72126416 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stem cell glial cell stromal cell tuft cell fibroblast ionocyte epithelial cell M cell chondrocyte cancer stem cell progenitor cell ductal cell Other: Signaling by WNT RNA Polymerase II Transcription Transcriptional regulation of testis differentiation STAT1 Gene Information Basic Information Ensembl ID: ENSG00000115415 Description: signal transducer and activator of transcription 1 [Source:HGNC Symbol;Acc:HGNC:11362] Location: 2:190908460-191020960 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell Regulatory T cell CD8+ T cell leukocyte secretory cell monocyte epithelial cell Other: Cytokine Signaling in Immune system Signaling by NOTCH RNA Polymerase II Transcription TCF7 Gene Information Basic Information Ensembl ID: ENSG00000081059 Description: transcription factor 7 [Source:HGNC Symbol;Acc:HGNC:11639] Location: 5:134114681-134151865 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell developing T cell T cell CD4+ T cell Specialized T cell innate lymphoid cell Other: Signaling by WNT RNA Polymerase II Transcription MITF-M-regulated melanocyte development TGFB1 Gene Information Basic Information Ensembl ID: ENSG00000105329 Description: transforming growth factor beta 1 [Source:HGNC Symbol;Acc:HGNC:11766] Location: 19:41301587-41353922 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell developing T cell T cell CD8+ T cell platelet Specialized T cell megakaryocyte Other: Platelet activation, signaling and aggregation RNA Polymerase II Transcription Cytokine Signaling in Immune system THBS1 Gene Information Basic Information Ensembl ID: ENSG00000137801 Description: thrombospondin 1 [Source:HGNC Symbol;Acc:HGNC:11785] Location: 15:39581079-39599466 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell epithelial cell macrophage fibroblast phagocyte stromal cell smooth muscle cell monocyte neutrophil megakaryocyte pericyte Other: Diseases of glycosylation Integrin cell surface interactions Non-integrin membrane-ECM interactions TNFRSF10A Gene Information Basic Information Ensembl ID: ENSG00000104689 Description: TNF receptor superfamily member 10a [Source:HGNC Symbol;Acc:HGNC:11904] Location: 8:23190452-23225102 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Follicular B cell Other: Apoptosis Cell surface interactions at the vascular wall Regulated Necrosis TNFRSF10B Gene Information Basic Information Ensembl ID: ENSG00000120889 Description: TNF receptor superfamily member 10b [Source:HGNC Symbol;Acc:HGNC:11905] Location: 8:23020133-23069031 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Cell surface interactions at the vascular wall Regulated Necrosis TNFRSF10C Gene Information Basic Information Ensembl ID: ENSG00000173535 Description: TNF receptor superfamily member 10c [Source:HGNC Symbol;Acc:HGNC:11906] Location: 8:23102921-23117445 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: RNA Polymerase II Transcription TNFRSF10D Gene Information Basic Information Ensembl ID: ENSG00000173530 Description: TNF receptor superfamily member 10d [Source:HGNC Symbol;Acc:HGNC:11907] Location: 8:23135588-23164027 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell dendritic cell Other: Cell surface interactions at the vascular wall RNA Polymerase II Transcription Death Receptor Signaling TNFRSF18 Gene Information Basic Information Ensembl ID: ENSG00000186891 Description: TNF receptor superfamily member 18 [Source:HGNC Symbol;Acc:HGNC:11914] Location: 1:1203508-1206592 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell dendritic cell Regulatory T cell Specialized T cell innate lymphoid cell Naive B cell developing T cell Other: Cytokine Signaling in Immune system RNA Polymerase II Transcription TP53 Gene Information Basic Information Ensembl ID: ENSG00000141510 Description: tumor protein p53 [Source:HGNC Symbol;Acc:HGNC:11998] Location: 17:7661779-7687546 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Cytokine Signaling in Immune system Signaling by NOTCH TWIST1 Gene Information Basic Information Ensembl ID: ENSG00000122691 Description: twist family bHLH transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:12428] Location: 7:19020991-19117636 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte embryonic cell fibroblast stromal cell epithelial cell mesenchymal cell Other: Cytokine Signaling in Immune system Cell junction organization RNA Polymerase II Transcription VEGFA Gene Information Basic Information Ensembl ID: ENSG00000112715 Description: vascular endothelial growth factor A [Source:HGNC Symbol;Acc:HGNC:12680] Location: 6:43770184-43786487 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell macrophage epithelial cell stem cell monocyte fibroblast microglia pancreatic cell granulocyte secretory cell astrocyte dendritic cell endothelial cell Other: Cytokine Signaling in Immune system Cellular responses to stress RNA Polymerase II Transcription
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression Pathway Hierarchies & Genes RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression (4 genes) Circadian clock RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 4 genes	CREBBP Gene Information Basic Information Ensembl ID: ENSG00000005339 Description: CREB binding protein [Source:HGNC Symbol;Acc:HGNC:2348] Location: 16:3725054-3880713 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes BMAL1:CLOCK,NPAS2 activates circadian expression HDAC3 Gene Information Basic Information Ensembl ID: ENSG00000171720 Description: histone deacetylase 3 [Source:HGNC Symbol;Acc:HGNC:4854] Location: 5:141620876-141636849 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Death Receptor Signaling Signaling by NOTCH Mitochondrial biogenesis PPARGC1A Gene Information Basic Information Ensembl ID: ENSG00000109819 Description: PPARG coactivator 1 alpha [Source:HGNC Symbol;Acc:HGNC:9237] Location: 4:23755041-23904089 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Mitochondrial biogenesis Epigenetic regulation of gene expression Cellular responses to stress RORC Gene Information Basic Information Ensembl ID: ENSG00000143365 Description: RAR related orphan receptor C [Source:HGNC Symbol;Acc:HGNC:10260] Location: 1:151806071-151831845 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: CD4+ T cell T cell innate lymphoid cell Specialized T cell Other: Cytokine Signaling in Immune system RNA Polymerase II Transcription Expression of BMAL (ARNTL), CLOCK, and NPAS2
Regulated Necrosis Pathway Hierarchies & Genes CASP8 activity is inhibited (8 genes) Programmed Cell Death Regulated Necrosis RIPK1-mediated regulated necrosis Regulation of necroptotic cell death CASP8 activity is inhibited 8 genes Pyroptosis (7 genes) Programmed Cell Death Regulated Necrosis Pyroptosis 7 genes	CASP3 Gene Information Basic Information Ensembl ID: ENSG00000164305 Description: caspase 3 [Source:HGNC Symbol;Acc:HGNC:1504] Location: 4:184627696-184650062 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron mast cell innate lymphoid cell progenitor cell stem cell basal cell Other: Apoptosis Cytokine Signaling in Immune system Degradation of the extracellular matrix CASP8 Gene Information Basic Information Ensembl ID: ENSG00000064012 Description: caspase 8 [Source:HGNC Symbol;Acc:HGNC:1509] Location: 2:201233443-201361836 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System FADD Gene Information Basic Information Ensembl ID: ENSG00000168040 Description: Fas associated via death domain [Source:HGNC Symbol;Acc:HGNC:3573] Location: 11:70203296-70207390 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Innate Immune System Regulated Necrosis FAS Gene Information Basic Information Ensembl ID: ENSG00000026103 Description: Fas cell surface death receptor [Source:HGNC Symbol;Acc:HGNC:11920] Location: 10:88953813-89029605 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: CD4+ T cell Regulatory T cell Other: Apoptosis Regulated Necrosis RNA Polymerase II Transcription FASLG Gene Information Basic Information Ensembl ID: ENSG00000117560 Description: Fas ligand [Source:HGNC Symbol;Acc:HGNC:11936] Location: 1:172659103-172666876 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell T cell Specialized T cell CD8+ T cell Other: Apoptosis Cytokine Signaling in Immune system Regulated Necrosis GZMB Gene Information Basic Information Ensembl ID: ENSG00000100453 Description: granzyme B [Source:HGNC Symbol;Acc:HGNC:4709] Location: 14:24630954-24634267 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: CD8+ T cell T cell innate lymphoid cell natural killer cell developing T cell Other: Apoptosis Signaling by NOTCH Regulated Necrosis IL18 Gene Information Basic Information Ensembl ID: ENSG00000150782 Description: interleukin 18 [Source:HGNC Symbol;Acc:HGNC:5986] Location: 11:112143251-112164096 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: kidney cell dendritic cell macrophage hematopoietic stem cell phagocyte stem cell leukocyte epithelial cell mast cell myeloid cell antigen presenting cell pneumocyte progenitor cell neutrophil monocyte Other: Cytokine Signaling in Immune system Regulated Necrosis Parasitic Infection Pathways IL1A Gene Information Basic Information Ensembl ID: ENSG00000115008 Description: interleukin 1 alpha [Source:HGNC Symbol;Acc:HGNC:5991] Location: 2:112773925-112784493 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell Other: Cytokine Signaling in Immune system Cellular responses to stress Regulated Necrosis IL1B Gene Information Basic Information Ensembl ID: ENSG00000125538 Description: interleukin 1 beta [Source:HGNC Symbol;Acc:HGNC:5992] Location: 2:112829751-112836816 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell neuron macrophage dendritic cell phagocyte monocyte progenitor cell myeloid cell antigen presenting cell Other: Regulated Necrosis Cytokine Signaling in Immune system Innate Immune System IRF2 Gene Information Basic Information Ensembl ID: ENSG00000168310 Description: interferon regulatory factor 2 [Source:HGNC Symbol;Acc:HGNC:6117] Location: 4:184385702-184474558 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Regulated Necrosis Factors involved in megakaryocyte development and platelet production TNFRSF10A Gene Information Basic Information Ensembl ID: ENSG00000104689 Description: TNF receptor superfamily member 10a [Source:HGNC Symbol;Acc:HGNC:11904] Location: 8:23190452-23225102 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Follicular B cell Other: Apoptosis Cell surface interactions at the vascular wall Regulated Necrosis TNFRSF10B Gene Information Basic Information Ensembl ID: ENSG00000120889 Description: TNF receptor superfamily member 10b [Source:HGNC Symbol;Acc:HGNC:11905] Location: 8:23020133-23069031 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Cell surface interactions at the vascular wall Regulated Necrosis TNFSF10 Gene Information Basic Information Ensembl ID: ENSG00000121858 Description: TNF superfamily member 10 [Source:HGNC Symbol;Acc:HGNC:11925] Location: 3:172505508-172523475 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell epithelial cell monocyte mast cell secretory cell Other: Apoptosis Regulated Necrosis Death Receptor Signaling TP53 Gene Information Basic Information Ensembl ID: ENSG00000141510 Description: tumor protein p53 [Source:HGNC Symbol;Acc:HGNC:11998] Location: 17:7661779-7687546 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Cytokine Signaling in Immune system Signaling by NOTCH TRAF2 Gene Information Basic Information Ensembl ID: ENSG00000127191 Description: TNF receptor associated factor 2 [Source:HGNC Symbol;Acc:HGNC:12032] Location: 9:136881912-136929221 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway Hierarchies & Genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (6 genes) Metabolism of proteins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 6 genes	CSF1 Gene Information Basic Information Ensembl ID: ENSG00000184371 Description: colony stimulating factor 1 [Source:HGNC Symbol;Acc:HGNC:2432] Location: 1:109910242-109930992 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell stromal cell mast cell microglia Other: MITF-M-regulated melanocyte development Cytokine Signaling in Immune system Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) FN1 Gene Information Basic Information Ensembl ID: ENSG00000115414 Description: fibronectin 1 [Source:HGNC Symbol;Acc:HGNC:3778] Location: 2:215360440-215436073 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell fibroblast endocrine cell pericyte epithelial cell stellate cell stem cell phagocyte muscle cell stromal cell smooth muscle cell thymic epithelial cell skeletal muscle cell mesenchymal cell Other: Cytokine Signaling in Immune system Degradation of the extracellular matrix Elastic fibre formation GZMH Gene Information Basic Information Ensembl ID: ENSG00000100450 Description: granzyme H [Source:HGNC Symbol;Acc:HGNC:4710] Location: 14:24606480-24609699 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell CD8+ T cell memory T cell developing T cell T cell Specialized T cell lymphocyte Cytotoxic Other: Peptide hormone metabolism Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) IL6 Gene Information Basic Information Ensembl ID: ENSG00000136244 Description: interleukin 6 [Source:HGNC Symbol;Acc:HGNC:6018] Location: 7:22725884-22732002 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte endothelial cell stromal cell smooth muscle cell CD4+ T cell vascular cell immune cell Other: Cytokine Signaling in Immune system Cellular responses to stress Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) LTBP1 Gene Information Basic Information Ensembl ID: ENSG00000049323 Description: latent transforming growth factor beta binding protein 1 [Source:HGNC Symbol;Acc:HGNC:6714] Location: 2:32946953-33399509 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell endocrine cell pericyte epithelial cell fibroblast stromal cell smooth muscle cell cardiomyocyte muscle cell platelet interstitial cell progenitor cell dendritic cell glial cell erythroblast megakaryocyte Other: Elastic fibre formation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein modification MMP2 Gene Information Basic Information Ensembl ID: ENSG00000087245 Description: matrix metallopeptidase 2 [Source:HGNC Symbol;Acc:HGNC:7166] Location: 16:55389700-55506691 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: mesenchymal cell smooth muscle cell Other: Cytokine Signaling in Immune system Degradation of the extracellular matrix Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Regulation of beta-cell development Pathway Hierarchies & Genes AKT-mediated inactivation of FOXO1A (3 genes) Developmental Biology Regulation of beta-cell development Regulation of gene expression in beta cells AKT-mediated inactivation of FOXO1A 3 genes Regulation of gene expression in beta cells (1 genes) Developmental Biology Regulation of beta-cell development Regulation of gene expression in beta cells 1 genes Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells (2 genes) Developmental Biology Regulation of beta-cell development Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 2 genes	AKT1 Gene Information Basic Information Ensembl ID: ENSG00000142208 Description: AKT serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:391] Location: 14:104769349-104795759 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Integrin signaling Apoptosis Cytokine Signaling in Immune system AKT2 Gene Information Basic Information Ensembl ID: ENSG00000105221 Description: AKT serine/threonine kinase 2 [Source:HGNC Symbol;Acc:HGNC:392] Location: 19:40230317-40285536 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: T cell Other: Apoptosis Cytokine Signaling in Immune system Adaptive Immune System AKT3 Gene Information Basic Information Ensembl ID: ENSG00000117020 Description: AKT serine/threonine kinase 3 [Source:HGNC Symbol;Acc:HGNC:393] Location: 1:243488233-243851079 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell neuron epithelial cell T cell fibroblast glial cell CD8+ T cell schwann cell Specialized T cell excitatory neuron smooth muscle cell Other: Apoptosis Cytokine Signaling in Immune system Adaptive Immune System CREBBP Gene Information Basic Information Ensembl ID: ENSG00000005339 Description: CREB binding protein [Source:HGNC Symbol;Acc:HGNC:2348] Location: 16:3725054-3880713 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes BMAL1:CLOCK,NPAS2 activates circadian expression HNF1A Gene Information Basic Information Ensembl ID: ENSG00000135100 Description: HNF1 homeobox A [Source:HGNC Symbol;Acc:HGNC:11621] Location: 12:120978543-121002512 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: T cell Other: Regulation of beta-cell development NOTCH1 Gene Information Basic Information Ensembl ID: ENSG00000148400 Description: notch receptor 1 [Source:HGNC Symbol;Acc:HGNC:7881] Location: 9:136494433-136546048 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte T cell stem cell cancer cell Other: Signaling by NOTCH Regulation of beta-cell development Cellular responses to stress
Regulation of mRNA stability by proteins that bind AU-rich elements Pathway Hierarchies & Genes KSRP (KHSRP) binds and destabilizes mRNA (1 genes) Metabolism of RNA Regulation of mRNA stability by proteins that bind AU-rich elements Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA 1 genes HuR (ELAVL1) binds and stabilizes mRNA (2 genes) Metabolism of RNA Regulation of mRNA stability by proteins that bind AU-rich elements HuR (ELAVL1) binds and stabilizes mRNA 2 genes KSRP (KHSRP) binds and destabilizes mRNA (1 genes) Metabolism of RNA Regulation of mRNA stability by proteins that bind AU-rich elements KSRP (KHSRP) binds and destabilizes mRNA 1 genes	AKT1 Gene Information Basic Information Ensembl ID: ENSG00000142208 Description: AKT serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:391] Location: 14:104769349-104795759 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Integrin signaling Apoptosis Cytokine Signaling in Immune system MAPK14 Gene Information Basic Information Ensembl ID: ENSG00000112062 Description: mitogen-activated protein kinase 14 [Source:HGNC Symbol;Acc:HGNC:6876] Location: 6:36027752-36122511 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Platelet homeostasis Cytokine Signaling in Immune system Mitochondrial biogenesis PRKCA Gene Information Basic Information Ensembl ID: ENSG00000154229 Description: protein kinase C alpha [Source:HGNC Symbol;Acc:HGNC:9393] Location: 17:66302613-66810743 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: bipolar cell Other: Transmission across Chemical Synapses Integration of energy metabolism Signaling by WNT TNFSF13 Gene Information Basic Information Ensembl ID: ENSG00000161955 Description: TNF superfamily member 13 [Source:HGNC Symbol;Acc:HGNC:11928] Location: 17:7558292-7561608 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell monocyte Other: Cytokine Signaling in Immune system Regulation of mRNA stability by proteins that bind AU-rich elements
Signal regulatory protein family interactions Pathway Hierarchies & Genes Signal regulatory protein family interactions (2 genes) Cell-Cell communication Signal regulatory protein family interactions 2 genes	CD47 Gene Information Basic Information Ensembl ID: ENSG00000196776 Description: CD47 molecule [Source:HGNC Symbol;Acc:HGNC:1682] Location: 3:108043091-108091862 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell pericyte epithelial cell T cell memory T cell endothelial cell megakaryocyte Other: Innate Immune System Cell surface interactions at the vascular wall Integrin cell surface interactions PTPN11 Gene Information Basic Information Ensembl ID: ENSG00000179295 Description: protein tyrosine phosphatase non-receptor type 11 [Source:HGNC Symbol;Acc:HGNC:9644] Location: 12:112418351-112509918 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System
Signaling by Erythropoietin Pathway Hierarchies & Genes Erythropoietin activates RAS (5 genes) Signal Transduction Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 3 genes Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS 2 genes Erythropoietin activates RAS (3 genes) Signal Transduction Signaling by Erythropoietin Erythropoietin activates RAS 3 genes Erythropoietin activates STAT5 (2 genes) Signal Transduction Signaling by Erythropoietin Erythropoietin activates STAT5 2 genes	HRAS Gene Information Basic Information Ensembl ID: ENSG00000174775 Description: HRas proto-oncogene%2C GTPase [Source:HGNC Symbol;Acc:HGNC:5173] Location: 11:532242-537321 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Transmission across Chemical Synapses Cytokine Signaling in Immune system Adaptive Immune System JAK2 Gene Information Basic Information Ensembl ID: ENSG00000096968 Description: Janus kinase 2 [Source:HGNC Symbol;Acc:HGNC:6192] Location: 9:4984390-5129948 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: fibroblast basophil dendritic cell Other: Chromatin modifying enzymes Cytokine Signaling in Immune system Signaling by Leptin KRAS Gene Information Basic Information Ensembl ID: ENSG00000133703 Description: KRAS proto-oncogene%2C GTPase [Source:HGNC Symbol;Acc:HGNC:6407] Location: 12:25205246-25250936 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Signaling by Non-Receptor Tyrosine Kinases Transmission across Chemical Synapses Cytokine Signaling in Immune system LYN Gene Information Basic Information Ensembl ID: ENSG00000254087 Description: LYN proto-oncogene%2C Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6735] Location: 8:55879835-56014169 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System NRAS Gene Information Basic Information Ensembl ID: ENSG00000213281 Description: NRAS proto-oncogene%2C GTPase [Source:HGNC Symbol;Acc:HGNC:7989] Location: 1:114704469-114716771 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell cancer cell Other: Signaling by Erythropoietin Signaling by Non-Receptor Tyrosine Kinases Signaling by Nuclear Receptors PIK3CA Gene Information Basic Information Ensembl ID: ENSG00000121879 Description: phosphatidylinositol-4%2C5-bisphosphate 3-kinase catalytic subunit alpha [Source:HGNC Symbol;Acc:HGNC:8975] Location: 3:179148114-179240093 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System PIK3CD Gene Information Basic Information Ensembl ID: ENSG00000171608 Description: phosphatidylinositol-4%2C5-bisphosphate 3-kinase catalytic subunit delta [Source:HGNC Symbol;Acc:HGNC:8977] Location: 1:9629889-9729114 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: developing T cell T cell hematopoietic cell Other: Cytokine Signaling in Immune system Adaptive Immune System Metabolism of lipids PIK3CG Gene Information Basic Information Ensembl ID: ENSG00000105851 Description: phosphatidylinositol-4%2C5-bisphosphate 3-kinase catalytic subunit gamma [Source:HGNC Symbol;Acc:HGNC:8978] Location: 7:106865278-106908980 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: tuft cell Other: Adaptive Immune System Signaling by GPCR Metabolism of lipids STAT5A Gene Information Basic Information Ensembl ID: ENSG00000126561 Description: signal transducer and activator of transcription 5A [Source:HGNC Symbol;Acc:HGNC:11366] Location: 17:42287547-42311943 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell CD4+ T cell adipocyte Other: Cytokine Signaling in Immune system Signaling by Leptin Signaling by Erythropoietin STAT5B Gene Information Basic Information Ensembl ID: ENSG00000173757 Description: signal transducer and activator of transcription 5B [Source:HGNC Symbol;Acc:HGNC:11367] Location: 17:42199176-42288633 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: trophoblast cell CD4+ T cell Other: Cytokine Signaling in Immune system Signaling by Leptin Signaling by Erythropoietin
Signaling by GPCR Pathway Hierarchies & Genes phospho-PLA2 pathway (1 genes) Signal Transduction Signaling by GPCR GPCR downstream signalling G alpha (i) signalling events Opioid Signalling G-protein mediated events PLC beta mediated events Ca-dependent events phospho-PLA2 pathway 1 genes Ca-dependent events (1 genes) Signal Transduction Signaling by GPCR GPCR downstream signalling G alpha (i) signalling events Opioid Signalling G-protein mediated events PLC beta mediated events Ca-dependent events 1 genes G alpha (i) signalling events (30 genes) Signal Transduction Signaling by GPCR GPCR ligand binding Class A/1 (Rhodopsin-like receptors) Peptide ligand-binding receptors Chemokine receptors bind chemokines 2 genes GPCR downstream signalling G alpha (i) signalling events 28 genes G alpha (s) signalling events (1 genes) Signal Transduction Signaling by GPCR GPCR ligand binding Class A/1 (Rhodopsin-like receptors) Nucleotide-like (purinergic) receptors Adenosine P1 receptors GPCR downstream signalling G alpha (s) signalling events 1 genes G alpha (s) signalling events (2 genes) Signal Transduction Signaling by GPCR GPCR ligand binding Class A/1 (Rhodopsin-like receptors) Eicosanoid ligand-binding receptors Prostanoid ligand receptors GPCR downstream signalling G alpha (s) signalling events 2 genes G alpha (i) signalling events (1 genes) Signal Transduction Signaling by GPCR GPCR ligand binding Class A/1 (Rhodopsin-like receptors) Peptide ligand-binding receptors GPCR downstream signalling G alpha (i) signalling events 1 genes EGFR Transactivation by Gastrin (4 genes) Signal Transduction Signaling by GPCR GPCR downstream signalling G alpha (q) signalling events Gastrin-CREB signalling pathway via PKC and MAPK EGFR Transactivation by Gastrin 4 genes G beta:gamma signalling through BTK (1 genes) Signal Transduction Signaling by GPCR GPCR downstream signalling G-protein beta:gamma signalling G beta:gamma signalling through BTK 1 genes G beta:gamma signalling through PI3Kgamma (4 genes) Signal Transduction Signaling by GPCR GPCR downstream signalling G-protein beta:gamma signalling G beta:gamma signalling through PI3Kgamma 4 genes GPER1 signaling (3 genes) Signal Transduction Signaling by GPCR GPCR downstream signalling G alpha (s) signalling events GPER1 signaling 3 genes Gastrin-CREB signalling pathway via PKC and MAPK (1 genes) Signal Transduction Signaling by GPCR GPCR downstream signalling G alpha (q) signalling events Gastrin-CREB signalling pathway via PKC and MAPK 1 genes Class A/1 (Rhodopsin-like receptors) (1 genes) Signal Transduction Signaling by GPCR GPCR ligand binding Class A/1 (Rhodopsin-like receptors) 1 genes Class B/2 (Secretin family receptors) (7 genes) Signal Transduction Signaling by GPCR GPCR ligand binding Class B/2 (Secretin family receptors) 7 genes G alpha (q) signalling events (1 genes) Signal Transduction Signaling by GPCR GPCR downstream signalling G alpha (q) signalling events 1 genes	ACKR3 Gene Information Basic Information Ensembl ID: ENSG00000144476 Description: atypical chemokine receptor 3 [Source:HGNC Symbol;Acc:HGNC:23692] Location: 2:236567787-236582354 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell stem cell fibroblast epithelial cell Other: Signaling by GPCR ADGRE1 Gene Information Basic Information Ensembl ID: ENSG00000174837 Description: adhesion G protein-coupled receptor E1 [Source:HGNC Symbol;Acc:HGNC:3336] Location: 19:6887566-6940459 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: eosinophil Other: Signaling by GPCR ADORA2A Gene Information Basic Information Ensembl ID: ENSG00000128271 Description: adenosine A2a receptor [Source:HGNC Symbol;Acc:HGNC:263] Location: 22:24417879-24442357 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Signaling by GPCR Surfactant metabolism Signaling by Receptor Tyrosine Kinases AKT1 Gene Information Basic Information Ensembl ID: ENSG00000142208 Description: AKT serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:391] Location: 14:104769349-104795759 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Integrin signaling Apoptosis Cytokine Signaling in Immune system AKT2 Gene Information Basic Information Ensembl ID: ENSG00000105221 Description: AKT serine/threonine kinase 2 [Source:HGNC Symbol;Acc:HGNC:392] Location: 19:40230317-40285536 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: T cell Other: Apoptosis Cytokine Signaling in Immune system Adaptive Immune System AKT3 Gene Information Basic Information Ensembl ID: ENSG00000117020 Description: AKT serine/threonine kinase 3 [Source:HGNC Symbol;Acc:HGNC:393] Location: 1:243488233-243851079 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell neuron epithelial cell T cell fibroblast glial cell CD8+ T cell schwann cell Specialized T cell excitatory neuron smooth muscle cell Other: Apoptosis Cytokine Signaling in Immune system Adaptive Immune System BTK Gene Information Basic Information Ensembl ID: ENSG00000010671 Description: Bruton tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:1133] Location: X:101349338-101390796 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell Naive B cell mast cell granulocyte Other: Adaptive Immune System Innate Immune System Signaling by GPCR CCL19 Gene Information Basic Information Ensembl ID: ENSG00000172724 Description: C-C motif chemokine ligand 19 [Source:HGNC Symbol;Acc:HGNC:10617] Location: 9:34689570-34691276 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stromal cell pericyte epithelial cell endothelial cell Other: Cytokine Signaling in Immune system Signaling by GPCR CCL2 Gene Information Basic Information Ensembl ID: ENSG00000108691 Description: C-C motif chemokine ligand 2 [Source:HGNC Symbol;Acc:HGNC:10618] Location: 17:34255274-34257208 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stromal cell endothelial cell neuron pericyte epithelial cell stem cell phagocyte fibroblast glial cell smooth muscle cell monocyte antigen presenting cell macrophage mesothelial cell transient amplifying cell Other: Cytokine Signaling in Immune system Cellular responses to stress Signaling by GPCR CCL20 Gene Information Basic Information Ensembl ID: ENSG00000115009 Description: C-C motif chemokine ligand 20 [Source:HGNC Symbol;Acc:HGNC:10619] Location: 2:227805739-227817564 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: phagocyte CD4+ T cell monocyte fibroblast epithelial cell macrophage M cell dendritic cell Other: Cytokine Signaling in Immune system Signaling by GPCR CCL22 Gene Information Basic Information Ensembl ID: ENSG00000102962 Description: C-C motif chemokine ligand 22 [Source:HGNC Symbol;Acc:HGNC:10621] Location: 16:57358783-57366189 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell Specialized T cell Other: Cytokine Signaling in Immune system Innate Immune System Signaling by GPCR CCL28 Gene Information Basic Information Ensembl ID: ENSG00000151882 Description: C-C motif chemokine ligand 28 [Source:HGNC Symbol;Acc:HGNC:17700] Location: 5:43376645-43412391 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell secretory cell acinar cell Other: Signaling by GPCR CCR1 Gene Information Basic Information Ensembl ID: ENSG00000163823 Description: C-C motif chemokine receptor 1 [Source:HGNC Symbol;Acc:HGNC:1602] Location: 3:46201711-46208313 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: macrophage myeloid cell monocyte Other: Cytokine Signaling in Immune system Signaling by GPCR CCR2 Gene Information Basic Information Ensembl ID: ENSG00000121807 Description: C-C motif chemokine receptor 2 [Source:HGNC Symbol;Acc:HGNC:1603] Location: 3:46353864-46360940 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: plasma cell monocyte Other: Cytokine Signaling in Immune system Innate Immune System Signaling by GPCR CCR3 Gene Information Basic Information Ensembl ID: ENSG00000183625 Description: C-C motif chemokine receptor 3 [Source:HGNC Symbol;Acc:HGNC:1604] Location: 3:46130890-46266706 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: basophil eosinophil Other: Signaling by GPCR CCR4 Gene Information Basic Information Ensembl ID: ENSG00000183813 Description: C-C motif chemokine receptor 4 [Source:HGNC Symbol;Acc:HGNC:1605] Location: 3:32951644-32957120 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Regulatory T cell Other: Signaling by GPCR CCR5 Gene Information Basic Information Ensembl ID: ENSG00000160791 Description: C-C motif chemokine receptor 5 [Source:HGNC Symbol;Acc:HGNC:1606] Location: 3:46370946-46376206 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: CD8+ T cell developing T cell Other: Cytokine Signaling in Immune system Signaling by GPCR Viral Infection Pathways CCR6 Gene Information Basic Information Ensembl ID: ENSG00000112486 Description: C-C motif chemokine receptor 6 [Source:HGNC Symbol;Acc:HGNC:1607] Location: 6:167111807-167139141 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell Regulatory T cell CD4+ T cell T cell memory B cell Other: Innate Immune System Signaling by GPCR CCR7 Gene Information Basic Information Ensembl ID: ENSG00000126353 Description: C-C motif chemokine receptor 7 [Source:HGNC Symbol;Acc:HGNC:1608] Location: 17:40551081-40565472 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: T cell effector T cell memory T cell developing T cell neutrophil CD8+ T cell memory B cell Other: Signaling by GPCR CCR8 Gene Information Basic Information Ensembl ID: ENSG00000179934 Description: C-C motif chemokine receptor 8 [Source:HGNC Symbol;Acc:HGNC:1609] Location: 3:39329709-39336269 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Regulatory T cell Other: Signaling by GPCR CCR9 Gene Information Basic Information Ensembl ID: ENSG00000173585 Description: C-C motif chemokine receptor 9 [Source:HGNC Symbol;Acc:HGNC:1610] Location: 3:45884425-45903174 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Specialized T cell Other: Signaling by GPCR CMKLR1 Gene Information Basic Information Ensembl ID: ENSG00000174600 Description: chemerin chemokine-like receptor 1 [Source:HGNC Symbol;Acc:HGNC:2121] Location: 12:108288044-108339317 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Signaling by GPCR CX3CL1 Gene Information Basic Information Ensembl ID: ENSG00000006210 Description: C-X3-C motif chemokine ligand 1 [Source:HGNC Symbol;Acc:HGNC:10647] Location: 16:57372477-57385044 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell Other: Signaling by GPCR CX3CR1 Gene Information Basic Information Ensembl ID: ENSG00000168329 Description: C-X3-C motif chemokine receptor 1 [Source:HGNC Symbol;Acc:HGNC:2558] Location: 3:39263495-39281735 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron natural killer cell memory T cell macrophage phagocyte monocyte T cell antigen presenting cell Specialized T cell Other: Signaling by GPCR Viral Infection Pathways CXCL10 Gene Information Basic Information Ensembl ID: ENSG00000169245 Description: C-X-C motif chemokine ligand 10 [Source:HGNC Symbol;Acc:HGNC:10637] Location: 4:76021118-76023497 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: monocyte phagocyte Other: Cytokine Signaling in Immune system Signaling by GPCR CXCL11 Gene Information Basic Information Ensembl ID: ENSG00000169248 Description: C-X-C motif chemokine ligand 11 [Source:HGNC Symbol;Acc:HGNC:10638] Location: 4:76033682-76041415 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Signaling by GPCR CXCL12 Gene Information Basic Information Ensembl ID: ENSG00000107562 Description: C-X-C motif chemokine ligand 12 [Source:HGNC Symbol;Acc:HGNC:10672] Location: 10:44370165-44386493 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stromal cell thymic epithelial cell stem cell endothelial cell fibroblast mesodermal cell smooth muscle cell antigen presenting cell mesenchymal cell mural cell preadipocyte adipocyte medullary reticular cell Other: Signaling by GPCR Signaling by Nuclear Receptors Signaling by Receptor Tyrosine Kinases CXCL13 Gene Information Basic Information Ensembl ID: ENSG00000156234 Description: C-X-C motif chemokine ligand 13 [Source:HGNC Symbol;Acc:HGNC:10639] Location: 4:77511753-77611834 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stem cell fibroblast CD4+ T cell T cell dendritic cell endothelial cell T helper cell reticular cell Other: Signaling by GPCR CXCL16 Gene Information Basic Information Ensembl ID: ENSG00000161921 Description: C-X-C motif chemokine ligand 16 [Source:HGNC Symbol;Acc:HGNC:16642] Location: 17:4733533-4739928 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell macrophage phagocyte monocyte myeloid cell antigen presenting cell Other: Signaling by GPCR CXCL5 Gene Information Basic Information Ensembl ID: ENSG00000163735 Description: C-X-C motif chemokine ligand 5 [Source:HGNC Symbol;Acc:HGNC:10642] Location: 4:73995642-73998677 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: phagocyte monocyte macrophage M cell Other: Signaling by GPCR CXCL9 Gene Information Basic Information Ensembl ID: ENSG00000138755 Description: C-X-C motif chemokine ligand 9 [Source:HGNC Symbol;Acc:HGNC:7098] Location: 4:76001275-76007509 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: monocyte CD4+ T cell Other: Signaling by GPCR CXCR1 Gene Information Basic Information Ensembl ID: ENSG00000163464 Description: C-X-C motif chemokine receptor 1 [Source:HGNC Symbol;Acc:HGNC:6026] Location: 2:218162841-218166962 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell platelet Other: Innate Immune System Signaling by GPCR CXCR2 Gene Information Basic Information Ensembl ID: ENSG00000180871 Description: C-X-C motif chemokine receptor 2 [Source:HGNC Symbol;Acc:HGNC:6027] Location: 2:218125289-218137251 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell neutrophil Other: Innate Immune System Signaling by GPCR CXCR3 Gene Information Basic Information Ensembl ID: ENSG00000186810 Description: C-X-C motif chemokine receptor 3 [Source:HGNC Symbol;Acc:HGNC:4540] Location: X:71615916-71618511 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell CD8+ T cell developing T cell dendritic cell T cell Regulatory T cell Specialized T cell antigen presenting cell CD4+ T cell T helper cell Other: Signaling by GPCR CXCR5 Gene Information Basic Information Ensembl ID: ENSG00000160683 Description: C-X-C motif chemokine receptor 5 [Source:HGNC Symbol;Acc:HGNC:1060] Location: 11:118883892-118897787 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: CD4+ T cell memory B cell marginal B cell Naive B cell T helper cell CD8+ T cell Other: Signaling by GPCR CXCR6 Gene Information Basic Information Ensembl ID: ENSG00000172215 Description: C-X-C motif chemokine receptor 6 [Source:HGNC Symbol;Acc:HGNC:16647] Location: 3:45940933-45948351 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell developing T cell Regulatory T cell T cell CD4+ T cell Specialized T cell CD8+ T cell innate lymphoid cell T helper cell Other: Signaling by GPCR EGFR Gene Information Basic Information Ensembl ID: ENSG00000146648 Description: epidermal growth factor receptor [Source:HGNC Symbol;Acc:HGNC:3236] Location: 7:55019017-55211628 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell endothelial cell trophoblast cell hepatocyte stem cell adipocyte fibroblast muscle cell stromal cell mesenchymal stem cell skeletal muscle cell cancer cell Other: Signaling by NOTCH Membrane Trafficking Signaling by GPCR FN1 Gene Information Basic Information Ensembl ID: ENSG00000115414 Description: fibronectin 1 [Source:HGNC Symbol;Acc:HGNC:3778] Location: 2:215360440-215436073 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell fibroblast endocrine cell pericyte epithelial cell stellate cell stem cell phagocyte muscle cell stromal cell smooth muscle cell thymic epithelial cell skeletal muscle cell mesenchymal cell Other: Cytokine Signaling in Immune system Degradation of the extracellular matrix Elastic fibre formation FZD7 Gene Information Basic Information Ensembl ID: ENSG00000155760 Description: frizzled class receptor 7 [Source:HGNC Symbol;Acc:HGNC:4045] Location: 2:202033855-202038441 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Parasitic Infection Pathways Signaling by WNT Signaling by GPCR HRAS Gene Information Basic Information Ensembl ID: ENSG00000174775 Description: HRas proto-oncogene%2C GTPase [Source:HGNC Symbol;Acc:HGNC:5173] Location: 11:532242-537321 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Transmission across Chemical Synapses Cytokine Signaling in Immune system Adaptive Immune System ITGA5 Gene Information Basic Information Ensembl ID: ENSG00000161638 Description: integrin subunit alpha 5 [Source:HGNC Symbol;Acc:HGNC:6141] Location: 12:54395261-54419266 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell epithelial cell stromal cell smooth muscle cell trophoblast cell mesenchymal stem cell fibroblast Other: Elastic fibre formation Fibronectin matrix formation Cell surface interactions at the vascular wall ITGB1 Gene Information Basic Information Ensembl ID: ENSG00000150093 Description: integrin subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:6153] Location: 10:32887273-33005792 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stellate cell pericyte trophoblast cell epithelial cell stromal cell stem cell endothelial cell smooth muscle cell fibroblast mesenchymal stem cell Other: Laminin interactions Cell surface interactions at the vascular wall Cytokine Signaling in Immune system KRAS Gene Information Basic Information Ensembl ID: ENSG00000133703 Description: KRAS proto-oncogene%2C GTPase [Source:HGNC Symbol;Acc:HGNC:6407] Location: 12:25205246-25250936 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Signaling by Non-Receptor Tyrosine Kinases Transmission across Chemical Synapses Cytokine Signaling in Immune system MAPK1 Gene Information Basic Information Ensembl ID: ENSG00000100030 Description: mitogen-activated protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:6871] Location: 22:21759657-21867680 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Transmission across Chemical Synapses Signaling by NODAL MAPK3 Gene Information Basic Information Ensembl ID: ENSG00000102882 Description: mitogen-activated protein kinase 3 [Source:HGNC Symbol;Acc:HGNC:6877] Location: 16:30114105-30123506 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Transmission across Chemical Synapses Signaling by NODAL NRAS Gene Information Basic Information Ensembl ID: ENSG00000213281 Description: NRAS proto-oncogene%2C GTPase [Source:HGNC Symbol;Acc:HGNC:7989] Location: 1:114704469-114716771 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell cancer cell Other: Signaling by Erythropoietin Signaling by Non-Receptor Tyrosine Kinases Signaling by Nuclear Receptors PIK3CA Gene Information Basic Information Ensembl ID: ENSG00000121879 Description: phosphatidylinositol-4%2C5-bisphosphate 3-kinase catalytic subunit alpha [Source:HGNC Symbol;Acc:HGNC:8975] Location: 3:179148114-179240093 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System PIK3CG Gene Information Basic Information Ensembl ID: ENSG00000105851 Description: phosphatidylinositol-4%2C5-bisphosphate 3-kinase catalytic subunit gamma [Source:HGNC Symbol;Acc:HGNC:8978] Location: 7:106865278-106908980 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: tuft cell Other: Adaptive Immune System Signaling by GPCR Metabolism of lipids PNOC Gene Information Basic Information Ensembl ID: ENSG00000168081 Description: prepronociceptin [Source:HGNC Symbol;Acc:HGNC:9163] Location: 8:28316986-28343355 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: inhibitory neuron Other: Signaling by GPCR PRKCA Gene Information Basic Information Ensembl ID: ENSG00000154229 Description: protein kinase C alpha [Source:HGNC Symbol;Acc:HGNC:9393] Location: 17:66302613-66810743 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: bipolar cell Other: Transmission across Chemical Synapses Integration of energy metabolism Signaling by WNT PTGDR2 Gene Information Basic Information Ensembl ID: ENSG00000183134 Description: prostaglandin D2 receptor 2 [Source:HGNC Symbol;Acc:HGNC:4502] Location: 11:60850933-60855950 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: innate lymphoid cell CD4+ T cell beta cell Other: Signaling by GPCR PTGER4 Gene Information Basic Information Ensembl ID: ENSG00000171522 Description: prostaglandin E receptor 4 [Source:HGNC Symbol;Acc:HGNC:9596] Location: 5:40679915-40693735 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell developing T cell T cell CD4+ T cell CD8+ T cell Other: Signaling by GPCR WNT11 Gene Information Basic Information Ensembl ID: ENSG00000085741 Description: Wnt family member 11 [Source:HGNC Symbol;Acc:HGNC:12776] Location: 11:76186325-76210736 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Signaling by WNT Signaling by GPCR Kidney development WNT2 Gene Information Basic Information Ensembl ID: ENSG00000105989 Description: Wnt family member 2 [Source:HGNC Symbol;Acc:HGNC:12780] Location: 7:117275451-117323152 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: fibroblast stromal cell mesenchymal cell Other: Signaling by WNT Signaling by GPCR WNT3 Gene Information Basic Information Ensembl ID: ENSG00000108379 Description: Wnt family member 3 [Source:HGNC Symbol;Acc:HGNC:12782] Location: 17:46762506-46833154 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Signaling by WNT Signaling by GPCR WNT5A Gene Information Basic Information Ensembl ID: ENSG00000114251 Description: Wnt family member 5A [Source:HGNC Symbol;Acc:HGNC:12784] Location: 3:55465715-55490539 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: fibroblast mesenchymal cell Other: Signaling by WNT Membrane Trafficking Signaling by GPCR WNT7B Gene Information Basic Information Ensembl ID: ENSG00000188064 Description: Wnt family member 7B [Source:HGNC Symbol;Acc:HGNC:12787] Location: 22:45920366-45977162 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron Other: Signaling by WNT Signaling by GPCR XCR1 Gene Information Basic Information Ensembl ID: ENSG00000173578 Description: X-C motif chemokine receptor 1 [Source:HGNC Symbol;Acc:HGNC:1625] Location: 3:46016990-46085825 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell Other: Signaling by GPCR
Signaling by Hippo Pathway Hierarchies & Genes Signaling by Hippo (1 genes) Signal Transduction Signaling by Hippo 1 genes	CASP3 Gene Information Basic Information Ensembl ID: ENSG00000164305 Description: caspase 3 [Source:HGNC Symbol;Acc:HGNC:1504] Location: 4:184627696-184650062 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron mast cell innate lymphoid cell progenitor cell stem cell basal cell Other: Apoptosis Cytokine Signaling in Immune system Degradation of the extracellular matrix
Signaling by Leptin Pathway Hierarchies & Genes Signaling by Leptin (7 genes) Signal Transduction Signaling by Leptin 7 genes	IRS1 Gene Information Basic Information Ensembl ID: ENSG00000169047 Description: insulin receptor substrate 1 [Source:HGNC Symbol;Acc:HGNC:6125] Location: 2:226731312-226799820 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Signaling by Leptin MAPK family signaling cascades JAK2 Gene Information Basic Information Ensembl ID: ENSG00000096968 Description: Janus kinase 2 [Source:HGNC Symbol;Acc:HGNC:6192] Location: 9:4984390-5129948 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: fibroblast basophil dendritic cell Other: Chromatin modifying enzymes Cytokine Signaling in Immune system Signaling by Leptin PTPN11 Gene Information Basic Information Ensembl ID: ENSG00000179295 Description: protein tyrosine phosphatase non-receptor type 11 [Source:HGNC Symbol;Acc:HGNC:9644] Location: 12:112418351-112509918 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System SOCS3 Gene Information Basic Information Ensembl ID: ENSG00000184557 Description: suppressor of cytokine signaling 3 [Source:HGNC Symbol;Acc:HGNC:19391] Location: 17:78356778-78360077 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell pericyte fibroblast stromal cell smooth muscle cell CD4+ T cell granulocyte epithelial cell monocyte basal cell developing T cell Other: Cytokine Signaling in Immune system Adaptive Immune System Signaling by Leptin STAT3 Gene Information Basic Information Ensembl ID: ENSG00000168610 Description: signal transducer and activator of transcription 3 [Source:HGNC Symbol;Acc:HGNC:11364] Location: 17:42313324-42388568 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: cancer cell Other: Apoptosis Cytokine Signaling in Immune system Cellular responses to stress STAT5A Gene Information Basic Information Ensembl ID: ENSG00000126561 Description: signal transducer and activator of transcription 5A [Source:HGNC Symbol;Acc:HGNC:11366] Location: 17:42287547-42311943 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell CD4+ T cell adipocyte Other: Cytokine Signaling in Immune system Signaling by Leptin Signaling by Erythropoietin STAT5B Gene Information Basic Information Ensembl ID: ENSG00000173757 Description: signal transducer and activator of transcription 5B [Source:HGNC Symbol;Acc:HGNC:11367] Location: 17:42199176-42288633 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: trophoblast cell CD4+ T cell Other: Cytokine Signaling in Immune system Signaling by Leptin Signaling by Erythropoietin
Signaling by NODAL Pathway Hierarchies & Genes Signaling by NODAL (4 genes) Developmental Biology Signaling by NODAL 4 genes	MAPK1 Gene Information Basic Information Ensembl ID: ENSG00000100030 Description: mitogen-activated protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:6871] Location: 22:21759657-21867680 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Transmission across Chemical Synapses Signaling by NODAL MAPK3 Gene Information Basic Information Ensembl ID: ENSG00000102882 Description: mitogen-activated protein kinase 3 [Source:HGNC Symbol;Acc:HGNC:6877] Location: 16:30114105-30123506 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Transmission across Chemical Synapses Signaling by NODAL SMAD2 Gene Information Basic Information Ensembl ID: ENSG00000175387 Description: SMAD family member 2 [Source:HGNC Symbol;Acc:HGNC:6768] Location: 18:47808957-47931146 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Signaling by NODAL Transcriptional regulation of pluripotent stem cells Post-translational protein modification SMAD3 Gene Information Basic Information Ensembl ID: ENSG00000166949 Description: SMAD family member 3 [Source:HGNC Symbol;Acc:HGNC:6769] Location: 15:67063763-67195173 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell stem cell mesenchymal cell Other: Signaling by NODAL Cytokine Signaling in Immune system Signaling by NOTCH
Signaling by NOTCH Pathway Hierarchies & Genes NOTCH4 Activation and Transmission of Signal to the Nucleus (1 genes) Signal Transduction Signaling by NOTCH Signaling by NOTCH1 Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH2 NOTCH2 Activation and Transmission of Signal to the Nucleus Signaling by NOTCH3 NOTCH3 Activation and Transmission of Signal to the Nucleus Signaling by NOTCH4 NOTCH4 Activation and Transmission of Signal to the Nucleus 1 genes NOTCH4 Intracellular Domain Regulates Transcription (4 genes) Signal Transduction Signaling by NOTCH Pre-NOTCH Expression and Processing Pre-NOTCH Transcription and Translation 3 genes Signaling by NOTCH1 NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH3 NOTCH3 Intracellular Domain Regulates Transcription Signaling by NOTCH4 NOTCH4 Intracellular Domain Regulates Transcription 1 genes NOTCH4 Intracellular Domain Regulates Transcription (2 genes) Signal Transduction Signaling by NOTCH Pre-NOTCH Expression and Processing Pre-NOTCH Processing in the Endoplasmic Reticulum Signaling by NOTCH1 NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH3 NOTCH3 Intracellular Domain Regulates Transcription 1 genes Signaling by NOTCH4 NOTCH4 Intracellular Domain Regulates Transcription 1 genes NOTCH1 Intracellular Domain Regulates Transcription (3 genes) Signal Transduction Signaling by NOTCH Signaling by NOTCH1 NOTCH1 Intracellular Domain Regulates Transcription 3 genes NOTCH2 intracellular domain regulates transcription (2 genes) Signal Transduction Signaling by NOTCH Signaling by NOTCH2 NOTCH2 intracellular domain regulates transcription 2 genes NOTCH3 Activation and Transmission of Signal to the Nucleus (2 genes) Signal Transduction Signaling by NOTCH Signaling by NOTCH3 NOTCH3 Activation and Transmission of Signal to the Nucleus 2 genes NOTCH3 Intracellular Domain Regulates Transcription (1 genes) Signal Transduction Signaling by NOTCH Signaling by NOTCH3 NOTCH3 Intracellular Domain Regulates Transcription 1 genes NOTCH4 Intracellular Domain Regulates Transcription (1 genes) Signal Transduction Signaling by NOTCH Signaling by NOTCH4 NOTCH4 Intracellular Domain Regulates Transcription 1 genes Negative regulation of NOTCH4 signaling (1 genes) Signal Transduction Signaling by NOTCH Signaling by NOTCH4 Negative regulation of NOTCH4 signaling 1 genes	AKT1 Gene Information Basic Information Ensembl ID: ENSG00000142208 Description: AKT serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:391] Location: 14:104769349-104795759 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Integrin signaling Apoptosis Cytokine Signaling in Immune system CCND1 Gene Information Basic Information Ensembl ID: ENSG00000110092 Description: cyclin D1 [Source:HGNC Symbol;Acc:HGNC:1582] Location: 11:69641156-69654474 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell endothelial cell pericyte monocyte fibroblast glial cell dendritic cell pancreatic cell M cell oligodendrocyte Other: Cytokine Signaling in Immune system Signaling by NOTCH Chromatin modifying enzymes CREBBP Gene Information Basic Information Ensembl ID: ENSG00000005339 Description: CREB binding protein [Source:HGNC Symbol;Acc:HGNC:2348] Location: 16:3725054-3880713 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes BMAL1:CLOCK,NPAS2 activates circadian expression E2F1 Gene Information Basic Information Ensembl ID: ENSG00000101412 Description: E2F transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:3113] Location: 20:33675477-33686385 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Signaling by NOTCH Cellular responses to stress EGF Gene Information Basic Information Ensembl ID: ENSG00000138798 Description: epidermal growth factor [Source:HGNC Symbol;Acc:HGNC:3229] Location: 4:109912883-110013766 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: skeletal muscle cell epithelial cell glial cell Other: Signaling by NOTCH Membrane Trafficking Cellular responses to stress EGFR Gene Information Basic Information Ensembl ID: ENSG00000146648 Description: epidermal growth factor receptor [Source:HGNC Symbol;Acc:HGNC:3236] Location: 7:55019017-55211628 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell endothelial cell trophoblast cell hepatocyte stem cell adipocyte fibroblast muscle cell stromal cell mesenchymal stem cell skeletal muscle cell cancer cell Other: Signaling by NOTCH Membrane Trafficking Signaling by GPCR FCER2 Gene Information Basic Information Ensembl ID: ENSG00000104921 Description: Fc epsilon receptor II [Source:HGNC Symbol;Acc:HGNC:3612] Location: 19:7688758-7702146 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell Follicular B cell dendritic cell Other: Cytokine Signaling in Immune system Signaling by NOTCH GZMB Gene Information Basic Information Ensembl ID: ENSG00000100453 Description: granzyme B [Source:HGNC Symbol;Acc:HGNC:4709] Location: 14:24630954-24634267 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: CD8+ T cell T cell innate lymphoid cell natural killer cell developing T cell Other: Apoptosis Signaling by NOTCH Regulated Necrosis HDAC3 Gene Information Basic Information Ensembl ID: ENSG00000171720 Description: histone deacetylase 3 [Source:HGNC Symbol;Acc:HGNC:4854] Location: 5:141620876-141636849 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Death Receptor Signaling Signaling by NOTCH Mitochondrial biogenesis HIF1A Gene Information Basic Information Ensembl ID: ENSG00000100644 Description: hypoxia inducible factor 1 subunit alpha [Source:HGNC Symbol;Acc:HGNC:4910] Location: 14:61695513-61748259 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell macrophage phagocyte microglia granulocyte monocyte myeloid cell antigen presenting cell innate lymphoid cell dendritic cell Other: Cytokine Signaling in Immune system Signaling by NOTCH Cellular responses to stress JAG1 Gene Information Basic Information Ensembl ID: ENSG00000101384 Description: jagged canonical Notch ligand 1 [Source:HGNC Symbol;Acc:HGNC:6188] Location: 20:10637684-10673999 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell pericyte smooth muscle cell mural cell Other: Signaling by NOTCH RNA Polymerase II Transcription Signaling by Rho GTPases, Miro GTPases and RHOBTB3 MYC Gene Information Basic Information Ensembl ID: ENSG00000136997 Description: MYC proto-oncogene%2C bHLH transcription factor [Source:HGNC Symbol;Acc:HGNC:7553] Location: 8:127735434-127742951 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte epithelial cell fibroblast stromal cell smooth muscle cell hematopoietic progenitor cell endothelial cell stem cell erythroblast muscle cell progenitor cell transient amplifying cell cancer stem cell B cell erythroid lineage cell Other: Cytokine Signaling in Immune system Signaling by NOTCH Signaling by WNT NOTCH1 Gene Information Basic Information Ensembl ID: ENSG00000148400 Description: notch receptor 1 [Source:HGNC Symbol;Acc:HGNC:7881] Location: 9:136494433-136546048 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte T cell stem cell cancer cell Other: Signaling by NOTCH Regulation of beta-cell development Cellular responses to stress NOTCH2 Gene Information Basic Information Ensembl ID: ENSG00000134250 Description: notch receptor 2 [Source:HGNC Symbol;Acc:HGNC:7882] Location: 1:119911553-120100779 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: goblet cell Other: Signaling by NOTCH RNA Polymerase II Transcription Diseases of glycosylation SMAD3 Gene Information Basic Information Ensembl ID: ENSG00000166949 Description: SMAD family member 3 [Source:HGNC Symbol;Acc:HGNC:6769] Location: 15:67063763-67195173 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell stem cell mesenchymal cell Other: Signaling by NODAL Cytokine Signaling in Immune system Signaling by NOTCH STAT1 Gene Information Basic Information Ensembl ID: ENSG00000115415 Description: signal transducer and activator of transcription 1 [Source:HGNC Symbol;Acc:HGNC:11362] Location: 2:190908460-191020960 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell Regulatory T cell CD8+ T cell leukocyte secretory cell monocyte epithelial cell Other: Cytokine Signaling in Immune system Signaling by NOTCH RNA Polymerase II Transcription TP53 Gene Information Basic Information Ensembl ID: ENSG00000141510 Description: tumor protein p53 [Source:HGNC Symbol;Acc:HGNC:11998] Location: 17:7661779-7687546 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Cytokine Signaling in Immune system Signaling by NOTCH
Signaling by Non-Receptor Tyrosine Kinases Pathway Hierarchies & Genes PTK6 Activates STAT3 (2 genes) Signal Transduction Signaling by Non-Receptor Tyrosine Kinases Signaling by PTK6 PTK6 Activates STAT3 2 genes PTK6 Expression (1 genes) Signal Transduction Signaling by Non-Receptor Tyrosine Kinases Signaling by PTK6 PTK6 Expression 1 genes PTK6 Regulates Cell Cycle (4 genes) Signal Transduction Signaling by Non-Receptor Tyrosine Kinases Signaling by PTK6 PTK6 Regulates Cell Cycle 4 genes PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (3 genes) Signal Transduction Signaling by Non-Receptor Tyrosine Kinases Signaling by PTK6 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 3 genes PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 (1 genes) Signal Transduction Signaling by Non-Receptor Tyrosine Kinases Signaling by PTK6 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 1 genes PTK6 promotes HIF1A stabilization (1 genes) Signal Transduction Signaling by Non-Receptor Tyrosine Kinases Signaling by PTK6 PTK6 promotes HIF1A stabilization 1 genes Signaling by PTK6 (2 genes) Signal Transduction Signaling by Non-Receptor Tyrosine Kinases Signaling by PTK6 2 genes	AKT1 Gene Information Basic Information Ensembl ID: ENSG00000142208 Description: AKT serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:391] Location: 14:104769349-104795759 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Integrin signaling Apoptosis Cytokine Signaling in Immune system CCND1 Gene Information Basic Information Ensembl ID: ENSG00000110092 Description: cyclin D1 [Source:HGNC Symbol;Acc:HGNC:1582] Location: 11:69641156-69654474 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell endothelial cell pericyte monocyte fibroblast glial cell dendritic cell pancreatic cell M cell oligodendrocyte Other: Cytokine Signaling in Immune system Signaling by NOTCH Chromatin modifying enzymes CCNE1 Gene Information Basic Information Ensembl ID: ENSG00000105173 Description: cyclin E1 [Source:HGNC Symbol;Acc:HGNC:1589] Location: 19:29811991-29824312 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: trophoblast cell Other: Cellular responses to stress Protein folding Synthesis of DNA CDK2 Gene Information Basic Information Ensembl ID: ENSG00000123374 Description: cyclin dependent kinase 2 [Source:HGNC Symbol;Acc:HGNC:1771] Location: 12:55966781-55972789 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Meiosis Cellular responses to stress DNA Double-Strand Break Repair CDK4 Gene Information Basic Information Ensembl ID: ENSG00000135446 Description: cyclin dependent kinase 4 [Source:HGNC Symbol;Acc:HGNC:1773] Location: 12:57747727-57756013 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: T cell schwann cell progenitor cell neural crest cell Other: Adipogenesis Meiosis Cellular responses to stress EGF Gene Information Basic Information Ensembl ID: ENSG00000138798 Description: epidermal growth factor [Source:HGNC Symbol;Acc:HGNC:3229] Location: 4:109912883-110013766 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: skeletal muscle cell epithelial cell glial cell Other: Signaling by NOTCH Membrane Trafficking Cellular responses to stress EGFR Gene Information Basic Information Ensembl ID: ENSG00000146648 Description: epidermal growth factor receptor [Source:HGNC Symbol;Acc:HGNC:3236] Location: 7:55019017-55211628 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell endothelial cell trophoblast cell hepatocyte stem cell adipocyte fibroblast muscle cell stromal cell mesenchymal stem cell skeletal muscle cell cancer cell Other: Signaling by NOTCH Membrane Trafficking Signaling by GPCR ERBB3 Gene Information Basic Information Ensembl ID: ENSG00000065361 Description: erb-b2 receptor tyrosine kinase 3 [Source:HGNC Symbol;Acc:HGNC:3431] Location: 12:56076799-56103505 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron glial cell schwann cell neural crest cell progenitor cell Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Non-Receptor Tyrosine Kinases HIF1A Gene Information Basic Information Ensembl ID: ENSG00000100644 Description: hypoxia inducible factor 1 subunit alpha [Source:HGNC Symbol;Acc:HGNC:4910] Location: 14:61695513-61748259 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell macrophage phagocyte microglia granulocyte monocyte myeloid cell antigen presenting cell innate lymphoid cell dendritic cell Other: Cytokine Signaling in Immune system Signaling by NOTCH Cellular responses to stress HRAS Gene Information Basic Information Ensembl ID: ENSG00000174775 Description: HRas proto-oncogene%2C GTPase [Source:HGNC Symbol;Acc:HGNC:5173] Location: 11:532242-537321 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Transmission across Chemical Synapses Cytokine Signaling in Immune system Adaptive Immune System KRAS Gene Information Basic Information Ensembl ID: ENSG00000133703 Description: KRAS proto-oncogene%2C GTPase [Source:HGNC Symbol;Acc:HGNC:6407] Location: 12:25205246-25250936 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Signaling by Non-Receptor Tyrosine Kinases Transmission across Chemical Synapses Cytokine Signaling in Immune system NRAS Gene Information Basic Information Ensembl ID: ENSG00000213281 Description: NRAS proto-oncogene%2C GTPase [Source:HGNC Symbol;Acc:HGNC:7989] Location: 1:114704469-114716771 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell cancer cell Other: Signaling by Erythropoietin Signaling by Non-Receptor Tyrosine Kinases Signaling by Nuclear Receptors SOCS3 Gene Information Basic Information Ensembl ID: ENSG00000184557 Description: suppressor of cytokine signaling 3 [Source:HGNC Symbol;Acc:HGNC:19391] Location: 17:78356778-78360077 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell pericyte fibroblast stromal cell smooth muscle cell CD4+ T cell granulocyte epithelial cell monocyte basal cell developing T cell Other: Cytokine Signaling in Immune system Adaptive Immune System Signaling by Leptin STAT3 Gene Information Basic Information Ensembl ID: ENSG00000168610 Description: signal transducer and activator of transcription 3 [Source:HGNC Symbol;Acc:HGNC:11364] Location: 17:42313324-42388568 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: cancer cell Other: Apoptosis Cytokine Signaling in Immune system Cellular responses to stress
Signaling by Nuclear Receptors Pathway Hierarchies & Genes Estrogen-dependent nuclear events downstream of ESR-membrane signaling (8 genes) Signal Transduction Signaling by Nuclear Receptors ESR-mediated signaling Extra-nuclear estrogen signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling 8 genes Estrogen-stimulated signaling through PRKCZ (4 genes) Signal Transduction Signaling by Nuclear Receptors ESR-mediated signaling Extra-nuclear estrogen signaling Estrogen-stimulated signaling through PRKCZ 4 genes Estrogen-dependent gene expression (5 genes) Signal Transduction Signaling by Nuclear Receptors ESR-mediated signaling Estrogen-dependent gene expression 5 genes Extra-nuclear estrogen signaling (5 genes) Signal Transduction Signaling by Nuclear Receptors ESR-mediated signaling Extra-nuclear estrogen signaling 5 genes NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux (1 genes) Signal Transduction Signaling by Nuclear Receptors NR1H2 and NR1H3-mediated signaling NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 1 genes	AKT1 Gene Information Basic Information Ensembl ID: ENSG00000142208 Description: AKT serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:391] Location: 14:104769349-104795759 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Integrin signaling Apoptosis Cytokine Signaling in Immune system AKT2 Gene Information Basic Information Ensembl ID: ENSG00000105221 Description: AKT serine/threonine kinase 2 [Source:HGNC Symbol;Acc:HGNC:392] Location: 19:40230317-40285536 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: T cell Other: Apoptosis Cytokine Signaling in Immune system Adaptive Immune System AKT3 Gene Information Basic Information Ensembl ID: ENSG00000117020 Description: AKT serine/threonine kinase 3 [Source:HGNC Symbol;Acc:HGNC:393] Location: 1:243488233-243851079 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell neuron epithelial cell T cell fibroblast glial cell CD8+ T cell schwann cell Specialized T cell excitatory neuron smooth muscle cell Other: Apoptosis Cytokine Signaling in Immune system Adaptive Immune System BCL2 Gene Information Basic Information Ensembl ID: ENSG00000171791 Description: BCL2 apoptosis regulator [Source:HGNC Symbol;Acc:HGNC:990] Location: 18:63123346-63320128 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: cancer cell Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System CCND1 Gene Information Basic Information Ensembl ID: ENSG00000110092 Description: cyclin D1 [Source:HGNC Symbol;Acc:HGNC:1582] Location: 11:69641156-69654474 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell endothelial cell pericyte monocyte fibroblast glial cell dendritic cell pancreatic cell M cell oligodendrocyte Other: Cytokine Signaling in Immune system Signaling by NOTCH Chromatin modifying enzymes CREBBP Gene Information Basic Information Ensembl ID: ENSG00000005339 Description: CREB binding protein [Source:HGNC Symbol;Acc:HGNC:2348] Location: 16:3725054-3880713 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes BMAL1:CLOCK,NPAS2 activates circadian expression CXCL12 Gene Information Basic Information Ensembl ID: ENSG00000107562 Description: C-X-C motif chemokine ligand 12 [Source:HGNC Symbol;Acc:HGNC:10672] Location: 10:44370165-44386493 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stromal cell thymic epithelial cell stem cell endothelial cell fibroblast mesodermal cell smooth muscle cell antigen presenting cell mesenchymal cell mural cell preadipocyte adipocyte medullary reticular cell Other: Signaling by GPCR Signaling by Nuclear Receptors Signaling by Receptor Tyrosine Kinases EGF Gene Information Basic Information Ensembl ID: ENSG00000138798 Description: epidermal growth factor [Source:HGNC Symbol;Acc:HGNC:3229] Location: 4:109912883-110013766 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: skeletal muscle cell epithelial cell glial cell Other: Signaling by NOTCH Membrane Trafficking Cellular responses to stress EGFR Gene Information Basic Information Ensembl ID: ENSG00000146648 Description: epidermal growth factor receptor [Source:HGNC Symbol;Acc:HGNC:3236] Location: 7:55019017-55211628 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell endothelial cell trophoblast cell hepatocyte stem cell adipocyte fibroblast muscle cell stromal cell mesenchymal stem cell skeletal muscle cell cancer cell Other: Signaling by NOTCH Membrane Trafficking Signaling by GPCR ESR1 Gene Information Basic Information Ensembl ID: ENSG00000091831 Description: estrogen receptor 1 [Source:HGNC Symbol;Acc:HGNC:3467] Location: 6:151656691-152129619 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: fibroblast stromal cell plasma cell Other: Cellular responses to stress Post-translational protein modification RNA Polymerase II Transcription GATA3 Gene Information Basic Information Ensembl ID: ENSG00000107485 Description: GATA binding protein 3 [Source:HGNC Symbol;Acc:HGNC:4172] Location: 10:8045378-8075198 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell epithelial cell trophoblast cell developing T cell Regulatory T cell phagocyte natural killer cell CD4+ T cell lymphocyte innate lymphoid cell T helper cell neuron Other: Cytokine Signaling in Immune system Post-translational protein modification RNA Polymerase II Transcription HDAC3 Gene Information Basic Information Ensembl ID: ENSG00000171720 Description: histone deacetylase 3 [Source:HGNC Symbol;Acc:HGNC:4854] Location: 5:141620876-141636849 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Death Receptor Signaling Signaling by NOTCH Mitochondrial biogenesis HRAS Gene Information Basic Information Ensembl ID: ENSG00000174775 Description: HRas proto-oncogene%2C GTPase [Source:HGNC Symbol;Acc:HGNC:5173] Location: 11:532242-537321 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Transmission across Chemical Synapses Cytokine Signaling in Immune system Adaptive Immune System IGF1R Gene Information Basic Information Ensembl ID: ENSG00000140443 Description: insulin like growth factor 1 receptor [Source:HGNC Symbol;Acc:HGNC:5465] Location: 15:98648539-98964530 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell endothelial cell epithelial cell fibroblast trophoblast cell adrenal cortical cell granulocyte smooth muscle cell Other: Signaling by Nuclear Receptors Signaling by Receptor Tyrosine Kinases Viral Infection Pathways KRAS Gene Information Basic Information Ensembl ID: ENSG00000133703 Description: KRAS proto-oncogene%2C GTPase [Source:HGNC Symbol;Acc:HGNC:6407] Location: 12:25205246-25250936 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Signaling by Non-Receptor Tyrosine Kinases Transmission across Chemical Synapses Cytokine Signaling in Immune system MAPK1 Gene Information Basic Information Ensembl ID: ENSG00000100030 Description: mitogen-activated protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:6871] Location: 22:21759657-21867680 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Transmission across Chemical Synapses Signaling by NODAL MAPK3 Gene Information Basic Information Ensembl ID: ENSG00000102882 Description: mitogen-activated protein kinase 3 [Source:HGNC Symbol;Acc:HGNC:6877] Location: 16:30114105-30123506 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Transmission across Chemical Synapses Signaling by NODAL MMP2 Gene Information Basic Information Ensembl ID: ENSG00000087245 Description: matrix metallopeptidase 2 [Source:HGNC Symbol;Acc:HGNC:7166] Location: 16:55389700-55506691 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: mesenchymal cell smooth muscle cell Other: Cytokine Signaling in Immune system Degradation of the extracellular matrix Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MMP9 Gene Information Basic Information Ensembl ID: ENSG00000100985 Description: matrix metallopeptidase 9 [Source:HGNC Symbol;Acc:HGNC:7176] Location: 20:46008908-46016561 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell macrophage phagocyte neutrophil monocyte osteoclast Other: Cytokine Signaling in Immune system Degradation of the extracellular matrix Collagen formation MYC Gene Information Basic Information Ensembl ID: ENSG00000136997 Description: MYC proto-oncogene%2C bHLH transcription factor [Source:HGNC Symbol;Acc:HGNC:7553] Location: 8:127735434-127742951 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte epithelial cell fibroblast stromal cell smooth muscle cell hematopoietic progenitor cell endothelial cell stem cell erythroblast muscle cell progenitor cell transient amplifying cell cancer stem cell B cell erythroid lineage cell Other: Cytokine Signaling in Immune system Signaling by NOTCH Signaling by WNT NRAS Gene Information Basic Information Ensembl ID: ENSG00000213281 Description: NRAS proto-oncogene%2C GTPase [Source:HGNC Symbol;Acc:HGNC:7989] Location: 1:114704469-114716771 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell cancer cell Other: Signaling by Erythropoietin Signaling by Non-Receptor Tyrosine Kinases Signaling by Nuclear Receptors PGR Gene Information Basic Information Ensembl ID: ENSG00000082175 Description: progesterone receptor [Source:HGNC Symbol;Acc:HGNC:8910] Location: 11:101029624-101129813 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cellular responses to stress Post-translational protein modification RNA Polymerase II Transcription PIK3CA Gene Information Basic Information Ensembl ID: ENSG00000121879 Description: phosphatidylinositol-4%2C5-bisphosphate 3-kinase catalytic subunit alpha [Source:HGNC Symbol;Acc:HGNC:8975] Location: 3:179148114-179240093 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System
Signaling by Receptor Tyrosine Kinases Pathway Hierarchies & Genes MET activates RAS signaling (3 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by Insulin receptor Insulin receptor signalling cascade IRS-mediated signalling SOS-mediated signalling Signaling by ERBB2 SHC1 events in ERBB2 signaling Signaling by ERBB4 SHC1 events in ERBB4 signaling Signaling by SCF-KIT Signaling by NTRKs Signaling by NTRK1 (TRKA) Signalling to ERKs Signalling to RAS p38MAPK events Signaling by EGFR GRB2 events in EGFR signaling Signaling by PDGF Downstream signal transduction Signaling by FGFR Signaling by FGFR1 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 Signaling by VEGF VEGFA-VEGFR2 Pathway VEGFR2 mediated cell proliferation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IGF1R signaling cascade IRS-related events triggered by IGF1R Signaling by MET MET activates RAS signaling 3 genes Signaling by LTK (9 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by Insulin receptor Insulin receptor signalling cascade IRS-mediated signalling PI3K Cascade Signaling by ERBB2 PI3K events in ERBB2 signaling Signaling by ERBB4 2 genes PI3K events in ERBB4 signaling Signaling by SCF-KIT Signaling by NTRKs Signaling by NTRK1 (TRKA) 4 genes PI3K/AKT activation 1 genes Signaling by EGFR GAB1 signalosome Signaling by PDGF Downstream signal transduction Signaling by FGFR Signaling by FGFR1 Downstream signaling of activated FGFR1 PI-3K cascade:FGFR1 Signaling by VEGF 1 genes VEGFA-VEGFR2 Pathway Signaling by ALK Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IGF1R signaling cascade IRS-related events triggered by IGF1R Signaling by MET MET activates PI3K/AKT signaling Signaling by LTK 1 genes IRS-related events triggered by IGF1R (1 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by Insulin receptor Insulin receptor signalling cascade IRS-mediated signalling PI3K Cascade PKB-mediated events PDE3B signalling Signaling by ERBB2 Downregulation of ERBB2 signaling Downregulation of ERBB2:ERBB3 signaling Signaling by VEGF VEGFA-VEGFR2 Pathway VEGFR2 mediated vascular permeability Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IGF1R signaling cascade IRS-related events triggered by IGF1R 1 genes Signal attenuation (2 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by FGFR Signaling by FGFR1 Negative regulation of FGFR1 signaling Spry regulation of FGF signaling Signaling by NTRKs Signaling by NTRK1 (TRKA) Signalling to ERKs Prolonged ERK activation events Frs2-mediated activation Signaling by Insulin receptor Insulin receptor signalling cascade Signal attenuation 2 genes MET activates STAT3 (6 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by SCF-KIT 3 genes Signaling by NTRKs Signaling by NTRK1 (TRKA) 2 genes Signalling to STAT3 Signaling by PDGF Downstream signal transduction Signaling by ALK STAT3 nuclear events downstream of ALK signaling Signaling by MET MET activates STAT3 1 genes VEGFA-VEGFR2 Pathway (1 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by ERBB2 Signaling by SCF-KIT Regulation of KIT signaling Signaling by NTRKs Signaling by NTRK2 (TRKB) Activated NTRK2 signals through FYN NTRK2 activates RAC1 Signaling by VEGF VEGFA-VEGFR2 Pathway 1 genes VEGFA-VEGFR2 Pathway (1 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by NTRKs Signaling by NTRK1 (TRKA) Signalling to ERKs Signalling to RAS p38MAPK events Signaling by VEGF VEGFA-VEGFR2 Pathway 1 genes VEGFR2 mediated cell proliferation (3 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by ERBB2 SHC1 events in ERBB2 signaling Signaling by SCF-KIT Regulation of KIT signaling Signaling by VEGF 2 genes VEGFA-VEGFR2 Pathway VEGFR2 mediated cell proliferation 1 genes VEGFR2 mediated vascular permeability (3 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by ERBB2 Downregulation of ERBB2 signaling Downregulation of ERBB2:ERBB3 signaling Signaling by VEGF 1 genes VEGFA-VEGFR2 Pathway VEGFR2 mediated vascular permeability 2 genes Downstream signal transduction (4 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by ERBB4 Nuclear signaling by ERBB4 3 genes Signaling by SCF-KIT Signaling by PDGF Downstream signal transduction 1 genes ERKs are inactivated (2 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by NTRKs Signaling by NTRK1 (TRKA) Nuclear Events (kinase and transcription factor activation) ERK/MAPK targets ERKs are inactivated 2 genes Frs2-mediated activation (1 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by NTRKs Signaling by NTRK1 (TRKA) Signalling to ERKs Prolonged ERK activation events Frs2-mediated activation 1 genes MET activates PTK2 signaling (3 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by PDGF 2 genes Signaling by MET MET promotes cell motility MET activates PTK2 signaling 1 genes NGF-independant TRKA activation (1 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by NTRKs Signaling by NTRK1 (TRKA) Activation of TRKA receptors NGF-independant TRKA activation 1 genes NGF-stimulated transcription (3 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by NTRKs Signaling by NTRK1 (TRKA) Nuclear Events (kinase and transcription factor activation) NGF-stimulated transcription 3 genes IRS-related events triggered by IGF1R (1 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IGF1R signaling cascade IRS-related events triggered by IGF1R 1 genes MET activates PTK2 signaling (8 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by MET MET promotes cell motility MET activates PTK2 signaling 8 genes VEGF binds to VEGFR leading to receptor dimerization (6 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by VEGF VEGF ligand-receptor interactions VEGF binds to VEGFR leading to receptor dimerization 6 genes VEGFR2 mediated vascular permeability (3 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by VEGF VEGFA-VEGFR2 Pathway VEGFR2 mediated vascular permeability 3 genes Downstream signal transduction (5 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by PDGF Downstream signal transduction 5 genes Neurophilin interactions with VEGF and VEGFR (1 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by VEGF Neurophilin interactions with VEGF and VEGFR 1 genes Regulation of KIT signaling (3 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by SCF-KIT Regulation of KIT signaling 3 genes STAT3 nuclear events downstream of ALK signaling (5 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by ALK STAT3 nuclear events downstream of ALK signaling 5 genes VEGFA-VEGFR2 Pathway (3 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by VEGF VEGFA-VEGFR2 Pathway 3 genes Signaling by ALK (3 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by ALK 3 genes Signaling by MST1 (1 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by MST1 1 genes	ADORA2A Gene Information Basic Information Ensembl ID: ENSG00000128271 Description: adenosine A2a receptor [Source:HGNC Symbol;Acc:HGNC:263] Location: 22:24417879-24442357 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Signaling by GPCR Surfactant metabolism Signaling by Receptor Tyrosine Kinases AKT1 Gene Information Basic Information Ensembl ID: ENSG00000142208 Description: AKT serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:391] Location: 14:104769349-104795759 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Integrin signaling Apoptosis Cytokine Signaling in Immune system AKT2 Gene Information Basic Information Ensembl ID: ENSG00000105221 Description: AKT serine/threonine kinase 2 [Source:HGNC Symbol;Acc:HGNC:392] Location: 19:40230317-40285536 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: T cell Other: Apoptosis Cytokine Signaling in Immune system Adaptive Immune System AKT3 Gene Information Basic Information Ensembl ID: ENSG00000117020 Description: AKT serine/threonine kinase 3 [Source:HGNC Symbol;Acc:HGNC:393] Location: 1:243488233-243851079 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell neuron epithelial cell T cell fibroblast glial cell CD8+ T cell schwann cell Specialized T cell excitatory neuron smooth muscle cell Other: Apoptosis Cytokine Signaling in Immune system Adaptive Immune System AXL Gene Information Basic Information Ensembl ID: ENSG00000167601 Description: AXL receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:905] Location: 19:41219223-41261766 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell pericyte dendritic cell stromal cell phagocyte fibroblast smooth muscle cell monocyte antigen presenting cell macrophage mesenchymal cell Other: Signaling by Receptor Tyrosine Kinases CD274 Gene Information Basic Information Ensembl ID: ENSG00000120217 Description: CD274 molecule [Source:HGNC Symbol;Acc:HGNC:17635] Location: 9:5450503-5470566 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: lymphocyte memory T cell CD8+ T cell CD4+ T cell Other: Adaptive Immune System Signaling by Receptor Tyrosine Kinases CDH5 Gene Information Basic Information Ensembl ID: ENSG00000179776 Description: cadherin 5 [Source:HGNC Symbol;Acc:HGNC:1764] Location: 16:66366690-66404784 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell neuron cardiomyocyte Other: Cell junction organization Signaling by Receptor Tyrosine Kinases Cellular responses to mechanical stimuli CHEK1 Gene Information Basic Information Ensembl ID: ENSG00000149554 Description: checkpoint kinase 1 [Source:HGNC Symbol;Acc:HGNC:1925] Location: 11:125625163-125676255 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: DNA Double-Strand Break Repair Cell Cycle Checkpoints RNA Polymerase II Transcription COL11A1 Gene Information Basic Information Ensembl ID: ENSG00000060718 Description: collagen type XI alpha 1 chain [Source:HGNC Symbol;Acc:HGNC:2186] Location: 1:102876467-103108872 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte fibroblast stromal cell oligodendrocyte precursor cell melanocyte oligodendrocyte Other: Degradation of the extracellular matrix Collagen formation Non-integrin membrane-ECM interactions COL5A1 Gene Information Basic Information Ensembl ID: ENSG00000130635 Description: collagen type V alpha 1 chain [Source:HGNC Symbol;Acc:HGNC:2209] Location: 9:134641803-134844843 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron pericyte stromal cell stellate cell fibroblast stem cell embryonic cell mesenchymal cell skeletal muscle cell Other: Degradation of the extracellular matrix Collagen formation Fibronectin matrix formation CTNNB1 Gene Information Basic Information Ensembl ID: ENSG00000168036 Description: catenin beta 1 [Source:HGNC Symbol;Acc:HGNC:2514] Location: 3:41194741-41260096 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell endothelial cell epithelial cell stem cell phagocyte adrenal cortical cell fibroblast monocyte Specialized T cell melanocyte M cell Other: Apoptosis Innate Immune System Signaling by WNT CXCL12 Gene Information Basic Information Ensembl ID: ENSG00000107562 Description: C-X-C motif chemokine ligand 12 [Source:HGNC Symbol;Acc:HGNC:10672] Location: 10:44370165-44386493 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stromal cell thymic epithelial cell stem cell endothelial cell fibroblast mesodermal cell smooth muscle cell antigen presenting cell mesenchymal cell mural cell preadipocyte adipocyte medullary reticular cell Other: Signaling by GPCR Signaling by Nuclear Receptors Signaling by Receptor Tyrosine Kinases DNMT1 Gene Information Basic Information Ensembl ID: ENSG00000130816 Description: DNA methyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:2976] Location: 19:10133342-10231286 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell lymphoid progenitor cell Follicular B cell Other: Epigenetic regulation of gene expression Post-translational protein modification Signaling by Receptor Tyrosine Kinases DUSP4 Gene Information Basic Information Ensembl ID: ENSG00000120875 Description: dual specificity phosphatase 4 [Source:HGNC Symbol;Acc:HGNC:3070] Location: 8:29333064-29350684 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell developing T cell Regulatory T cell Specialized T cell autonomic neuron Other: Cytokine Signaling in Immune system Innate Immune System MAPK family signaling cascades DUSP6 Gene Information Basic Information Ensembl ID: ENSG00000139318 Description: dual specificity phosphatase 6 [Source:HGNC Symbol;Acc:HGNC:3072] Location: 12:89347235-89352501 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell endothelial cell phagocyte mast cell monocyte granulocyte myeloid cell innate lymphoid cell Other: Cytokine Signaling in Immune system Innate Immune System MAPK family signaling cascades EGF Gene Information Basic Information Ensembl ID: ENSG00000138798 Description: epidermal growth factor [Source:HGNC Symbol;Acc:HGNC:3229] Location: 4:109912883-110013766 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: skeletal muscle cell epithelial cell glial cell Other: Signaling by NOTCH Membrane Trafficking Cellular responses to stress EGFR Gene Information Basic Information Ensembl ID: ENSG00000146648 Description: epidermal growth factor receptor [Source:HGNC Symbol;Acc:HGNC:3236] Location: 7:55019017-55211628 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell endothelial cell trophoblast cell hepatocyte stem cell adipocyte fibroblast muscle cell stromal cell mesenchymal stem cell skeletal muscle cell cancer cell Other: Signaling by NOTCH Membrane Trafficking Signaling by GPCR ERBB3 Gene Information Basic Information Ensembl ID: ENSG00000065361 Description: erb-b2 receptor tyrosine kinase 3 [Source:HGNC Symbol;Acc:HGNC:3431] Location: 12:56076799-56103505 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron glial cell schwann cell neural crest cell progenitor cell Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Non-Receptor Tyrosine Kinases ESR1 Gene Information Basic Information Ensembl ID: ENSG00000091831 Description: estrogen receptor 1 [Source:HGNC Symbol;Acc:HGNC:3467] Location: 6:151656691-152129619 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: fibroblast stromal cell plasma cell Other: Cellular responses to stress Post-translational protein modification RNA Polymerase II Transcription FGF18 Gene Information Basic Information Ensembl ID: ENSG00000156427 Description: fibroblast growth factor 18 [Source:HGNC Symbol;Acc:HGNC:3674] Location: 5:171419647-171457626 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases FGF2 Gene Information Basic Information Ensembl ID: ENSG00000138685 Description: fibroblast growth factor 2 [Source:HGNC Symbol;Acc:HGNC:3676] Location: 4:122826682-122898236 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: fibroblast glial cell adipocyte Other: Non-integrin membrane-ECM interactions Cytokine Signaling in Immune system Transcriptional regulation of pluripotent stem cells FGFR1 Gene Information Basic Information Ensembl ID: ENSG00000077782 Description: fibroblast growth factor receptor 1 [Source:HGNC Symbol;Acc:HGNC:3688] Location: 8:38400215-38468834 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell fibroblast epithelial cell stem cell stromal cell Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases FGFR3 Gene Information Basic Information Ensembl ID: ENSG00000068078 Description: fibroblast growth factor receptor 3 [Source:HGNC Symbol;Acc:HGNC:3690] Location: 4:1793293-1808872 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stem cell astrocyte epithelial cell Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases FLT1 Gene Information Basic Information Ensembl ID: ENSG00000102755 Description: fms related receptor tyrosine kinase 1 [Source:HGNC Symbol;Acc:HGNC:3763] Location: 13:28300346-28495145 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell trophoblast cell vascular cell Other: Signaling by Receptor Tyrosine Kinases FLT3 Gene Information Basic Information Ensembl ID: ENSG00000122025 Description: fms related receptor tyrosine kinase 3 [Source:HGNC Symbol;Acc:HGNC:3765] Location: 13:28003274-28100592 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell Other: MAPK family signaling cascades Cytokine Signaling in Immune system Intracellular signaling by second messengers FN1 Gene Information Basic Information Ensembl ID: ENSG00000115414 Description: fibronectin 1 [Source:HGNC Symbol;Acc:HGNC:3778] Location: 2:215360440-215436073 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell fibroblast endocrine cell pericyte epithelial cell stellate cell stem cell phagocyte muscle cell stromal cell smooth muscle cell thymic epithelial cell skeletal muscle cell mesenchymal cell Other: Cytokine Signaling in Immune system Degradation of the extracellular matrix Elastic fibre formation FOSL1 Gene Information Basic Information Ensembl ID: ENSG00000175592 Description: FOS like 1%2C AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:13718] Location: 11:65892049-65900573 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell stem cell dendritic cell Other: Signaling by Receptor Tyrosine Kinases FYN Gene Information Basic Information Ensembl ID: ENSG00000010810 Description: FYN proto-oncogene%2C Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:4037] Location: 6:111660332-111873452 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Cellular responses to mechanical stimuli HDAC3 Gene Information Basic Information Ensembl ID: ENSG00000171720 Description: histone deacetylase 3 [Source:HGNC Symbol;Acc:HGNC:4854] Location: 5:141620876-141636849 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Death Receptor Signaling Signaling by NOTCH Mitochondrial biogenesis HGF Gene Information Basic Information Ensembl ID: ENSG00000019991 Description: hepatocyte growth factor [Source:HGNC Symbol;Acc:HGNC:4893] Location: 7:81699010-81770438 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stellate cell fibroblast stromal cell bone cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades Platelet activation, signaling and aggregation HIF1A Gene Information Basic Information Ensembl ID: ENSG00000100644 Description: hypoxia inducible factor 1 subunit alpha [Source:HGNC Symbol;Acc:HGNC:4910] Location: 14:61695513-61748259 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell macrophage phagocyte microglia granulocyte monocyte myeloid cell antigen presenting cell innate lymphoid cell dendritic cell Other: Cytokine Signaling in Immune system Signaling by NOTCH Cellular responses to stress HRAS Gene Information Basic Information Ensembl ID: ENSG00000174775 Description: HRas proto-oncogene%2C GTPase [Source:HGNC Symbol;Acc:HGNC:5173] Location: 11:532242-537321 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Transmission across Chemical Synapses Cytokine Signaling in Immune system Adaptive Immune System ID2 Gene Information Basic Information Ensembl ID: ENSG00000115738 Description: inhibitor of DNA binding 2 [Source:HGNC Symbol;Acc:HGNC:5361] Location: 2:8678845-8684461 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell developing T cell dendritic cell macrophage T cell CD4+ T cell endothelial cell mast cell CD8+ T cell enteroendocrine cell Specialized T cell innate lymphoid cell Other: Signaling by Receptor Tyrosine Kinases ID4 Gene Information Basic Information Ensembl ID: ENSG00000172201 Description: inhibitor of DNA binding 4 [Source:HGNC Symbol;Acc:HGNC:5363] Location: 6:19837370-19842197 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte epithelial cell progenitor cell stem cell glial cell stromal cell smooth muscle cell fibroblast muscle cell astrocyte Other: Signaling by Receptor Tyrosine Kinases Kidney development IGF1R Gene Information Basic Information Ensembl ID: ENSG00000140443 Description: insulin like growth factor 1 receptor [Source:HGNC Symbol;Acc:HGNC:5465] Location: 15:98648539-98964530 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell endothelial cell epithelial cell fibroblast trophoblast cell adrenal cortical cell granulocyte smooth muscle cell Other: Signaling by Nuclear Receptors Signaling by Receptor Tyrosine Kinases Viral Infection Pathways IL2RG Gene Information Basic Information Ensembl ID: ENSG00000147168 Description: interleukin 2 receptor subunit gamma [Source:HGNC Symbol;Acc:HGNC:6010] Location: X:71107404-71112108 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell CD8+ T cell developing T cell T cell Regulatory T cell leukocyte Specialized T cell lymphocyte Other: Cytokine Signaling in Immune system MAPK family signaling cascades Signaling by Receptor Tyrosine Kinases IRS1 Gene Information Basic Information Ensembl ID: ENSG00000169047 Description: insulin receptor substrate 1 [Source:HGNC Symbol;Acc:HGNC:6125] Location: 2:226731312-226799820 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Signaling by Leptin MAPK family signaling cascades ITGA2 Gene Information Basic Information Ensembl ID: ENSG00000164171 Description: integrin subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:6137] Location: 5:52989340-53094779 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell stem cell pancreatic cell goblet cell Other: Integrin cell surface interactions Laminin interactions Non-integrin membrane-ECM interactions ITGAV Gene Information Basic Information Ensembl ID: ENSG00000138448 Description: integrin subunit alpha V [Source:HGNC Symbol;Acc:HGNC:6150] Location: 2:186590010-186680901 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell glial cell stromal cell M cell endothelial cell Other: Adaptive Immune System Elastic fibre formation Innate Immune System ITGB1 Gene Information Basic Information Ensembl ID: ENSG00000150093 Description: integrin subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:6153] Location: 10:32887273-33005792 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stellate cell pericyte trophoblast cell epithelial cell stromal cell stem cell endothelial cell smooth muscle cell fibroblast mesenchymal stem cell Other: Laminin interactions Cell surface interactions at the vascular wall Cytokine Signaling in Immune system ITGB3 Gene Information Basic Information Ensembl ID: ENSG00000259207 Description: integrin subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:6156] Location: 17:47253827-47313743 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: platelet epithelial cell monocyte Other: ECM proteoglycans Elastic fibre formation Cell surface interactions at the vascular wall JAK2 Gene Information Basic Information Ensembl ID: ENSG00000096968 Description: Janus kinase 2 [Source:HGNC Symbol;Acc:HGNC:6192] Location: 9:4984390-5129948 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: fibroblast basophil dendritic cell Other: Chromatin modifying enzymes Cytokine Signaling in Immune system Signaling by Leptin JAK3 Gene Information Basic Information Ensembl ID: ENSG00000105639 Description: Janus kinase 3 [Source:HGNC Symbol;Acc:HGNC:6193] Location: 19:17824780-17848071 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Specialized T cell CD4+ T cell T cell CD8+ T cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades Signaling by Receptor Tyrosine Kinases KDR Gene Information Basic Information Ensembl ID: ENSG00000128052 Description: kinase insert domain receptor [Source:HGNC Symbol;Acc:HGNC:6307] Location: 4:55078481-55125595 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell glial cell stromal cell mesothelial cell cancer stem cell Other: Integrin cell surface interactions Signaling by Receptor Tyrosine Kinases Cellular responses to mechanical stimuli KIT Gene Information Basic Information Ensembl ID: ENSG00000157404 Description: KIT proto-oncogene%2C receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6342] Location: 4:54657267-54740783 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell intercalated cell tuft cell brush cell mast cell progenitor cell stem cell melanocyte Specialized T cell hematopoietic progenitor cell hematopoietic cell cancer stem cell stromal cell interstitial cell Other: MAPK family signaling cascades RNA Polymerase II Transcription Intracellular signaling by second messengers KRAS Gene Information Basic Information Ensembl ID: ENSG00000133703 Description: KRAS proto-oncogene%2C GTPase [Source:HGNC Symbol;Acc:HGNC:6407] Location: 12:25205246-25250936 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Signaling by Non-Receptor Tyrosine Kinases Transmission across Chemical Synapses Cytokine Signaling in Immune system LAMB3 Gene Information Basic Information Ensembl ID: ENSG00000196878 Description: laminin subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:6490] Location: 1:209614870-209652425 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell stem cell pancreatic cell goblet cell M cell Other: Degradation of the extracellular matrix Collagen formation Laminin interactions LAMC2 Gene Information Basic Information Ensembl ID: ENSG00000058085 Description: laminin subunit gamma 2 [Source:HGNC Symbol;Acc:HGNC:6493] Location: 1:183186238-183245127 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell pancreatic cell goblet cell M cell stem cell Other: Degradation of the extracellular matrix Collagen formation Laminin interactions LCK Gene Information Basic Information Ensembl ID: ENSG00000182866 Description: LCK proto-oncogene%2C Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6524] Location: 1:32251244-32286165 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell CD8+ T cell developing T cell T cell lymphocyte Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System LYN Gene Information Basic Information Ensembl ID: ENSG00000254087 Description: LYN proto-oncogene%2C Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6735] Location: 8:55879835-56014169 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System MAP2K1 Gene Information Basic Information Ensembl ID: ENSG00000169032 Description: mitogen-activated protein kinase kinase 1 [Source:HGNC Symbol;Acc:HGNC:6840] Location: 15:66386837-66491656 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Innate Immune System MAPK family signaling cascades MAPK1 Gene Information Basic Information Ensembl ID: ENSG00000100030 Description: mitogen-activated protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:6871] Location: 22:21759657-21867680 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Transmission across Chemical Synapses Signaling by NODAL MAPK14 Gene Information Basic Information Ensembl ID: ENSG00000112062 Description: mitogen-activated protein kinase 14 [Source:HGNC Symbol;Acc:HGNC:6876] Location: 6:36027752-36122511 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Platelet homeostasis Cytokine Signaling in Immune system Mitochondrial biogenesis MAPK3 Gene Information Basic Information Ensembl ID: ENSG00000102882 Description: mitogen-activated protein kinase 3 [Source:HGNC Symbol;Acc:HGNC:6877] Location: 16:30114105-30123506 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Transmission across Chemical Synapses Signaling by NODAL MET Gene Information Basic Information Ensembl ID: ENSG00000105976 Description: MET proto-oncogene%2C receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:7029] Location: 7:116672196-116798377 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell pancreatic cell melanocyte Other: MAPK family signaling cascades RNA Polymerase II Transcription Intracellular signaling by second messengers MMP9 Gene Information Basic Information Ensembl ID: ENSG00000100985 Description: matrix metallopeptidase 9 [Source:HGNC Symbol;Acc:HGNC:7176] Location: 20:46008908-46016561 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell macrophage phagocyte neutrophil monocyte osteoclast Other: Cytokine Signaling in Immune system Degradation of the extracellular matrix Collagen formation MST1R Gene Information Basic Information Ensembl ID: ENSG00000164078 Description: macrophage stimulating 1 receptor [Source:HGNC Symbol;Acc:HGNC:7381] Location: 3:49886902-49903873 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Signaling by Receptor Tyrosine Kinases MTOR Gene Information Basic Information Ensembl ID: ENSG00000198793 Description: mechanistic target of rapamycin kinase [Source:HGNC Symbol;Acc:HGNC:3942] Location: 1:11106535-11262556 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Adaptive Immune System Macroautophagy MTOR signalling MYC Gene Information Basic Information Ensembl ID: ENSG00000136997 Description: MYC proto-oncogene%2C bHLH transcription factor [Source:HGNC Symbol;Acc:HGNC:7553] Location: 8:127735434-127742951 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte epithelial cell fibroblast stromal cell smooth muscle cell hematopoietic progenitor cell endothelial cell stem cell erythroblast muscle cell progenitor cell transient amplifying cell cancer stem cell B cell erythroid lineage cell Other: Cytokine Signaling in Immune system Signaling by NOTCH Signaling by WNT MYCN Gene Information Basic Information Ensembl ID: ENSG00000134323 Description: MYCN proto-oncogene%2C bHLH transcription factor [Source:HGNC Symbol;Acc:HGNC:7559] Location: 2:15940550-15947007 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell Other: Cell junction organization Signaling by Receptor Tyrosine Kinases Signaling by TGFB family members NRAS Gene Information Basic Information Ensembl ID: ENSG00000213281 Description: NRAS proto-oncogene%2C GTPase [Source:HGNC Symbol;Acc:HGNC:7989] Location: 1:114704469-114716771 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell cancer cell Other: Signaling by Erythropoietin Signaling by Non-Receptor Tyrosine Kinases Signaling by Nuclear Receptors NRP1 Gene Information Basic Information Ensembl ID: ENSG00000099250 Description: neuropilin 1 [Source:HGNC Symbol;Acc:HGNC:8004] Location: 10:33177492-33336262 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Signaling by Receptor Tyrosine Kinases Nervous system development Viral Infection Pathways PDGFA Gene Information Basic Information Ensembl ID: ENSG00000197461 Description: platelet derived growth factor subunit A [Source:HGNC Symbol;Acc:HGNC:8799] Location: 7:497258-520296 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte smooth muscle cell Specialized T cell secretory cell Other: Cellular responses to stress Non-integrin membrane-ECM interactions MAPK family signaling cascades PDGFB Gene Information Basic Information Ensembl ID: ENSG00000100311 Description: platelet derived growth factor subunit B [Source:HGNC Symbol;Acc:HGNC:8800] Location: 22:39223359-39244982 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell Other: Non-integrin membrane-ECM interactions MAPK family signaling cascades Platelet activation, signaling and aggregation PDGFC Gene Information Basic Information Ensembl ID: ENSG00000145431 Description: platelet derived growth factor C [Source:HGNC Symbol;Acc:HGNC:8801] Location: 4:156760454-156971799 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell macrophage phagocyte fibroblast Other: Signaling by Receptor Tyrosine Kinases PDGFRA Gene Information Basic Information Ensembl ID: ENSG00000134853 Description: platelet derived growth factor receptor alpha [Source:HGNC Symbol;Acc:HGNC:8803] Location: 4:54229280-54298245 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: fibroblast pericyte stellate cell stem cell embryonic cell stromal cell smooth muscle cell oligodendrocyte precursor cell epithelial cell oligodendrocyte progenitor cell mesodermal cell valve interstitial cell Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases PDGFRB Gene Information Basic Information Ensembl ID: ENSG00000113721 Description: platelet derived growth factor receptor beta [Source:HGNC Symbol;Acc:HGNC:8804] Location: 5:150113839-150155872 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: smooth muscle cell stellate cell endothelial cell pericyte fibroblast stromal cell mural cell adipocyte neuron mesenchymal cell vascular cell Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases PGF Gene Information Basic Information Ensembl ID: ENSG00000119630 Description: placental growth factor [Source:HGNC Symbol;Acc:HGNC:8893] Location: 14:74941834-74955626 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell pericyte trophoblast cell stromal cell smooth muscle cell epithelial cell fibroblast adipocyte Other: Signaling by Receptor Tyrosine Kinases PGR Gene Information Basic Information Ensembl ID: ENSG00000082175 Description: progesterone receptor [Source:HGNC Symbol;Acc:HGNC:8910] Location: 11:101029624-101129813 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cellular responses to stress Post-translational protein modification RNA Polymerase II Transcription PIK3CA Gene Information Basic Information Ensembl ID: ENSG00000121879 Description: phosphatidylinositol-4%2C5-bisphosphate 3-kinase catalytic subunit alpha [Source:HGNC Symbol;Acc:HGNC:8975] Location: 3:179148114-179240093 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System PRKCA Gene Information Basic Information Ensembl ID: ENSG00000154229 Description: protein kinase C alpha [Source:HGNC Symbol;Acc:HGNC:9393] Location: 17:66302613-66810743 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: bipolar cell Other: Transmission across Chemical Synapses Integration of energy metabolism Signaling by WNT PTPN11 Gene Information Basic Information Ensembl ID: ENSG00000179295 Description: protein tyrosine phosphatase non-receptor type 11 [Source:HGNC Symbol;Acc:HGNC:9644] Location: 12:112418351-112509918 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System STAT1 Gene Information Basic Information Ensembl ID: ENSG00000115415 Description: signal transducer and activator of transcription 1 [Source:HGNC Symbol;Acc:HGNC:11362] Location: 2:190908460-191020960 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell Regulatory T cell CD8+ T cell leukocyte secretory cell monocyte epithelial cell Other: Cytokine Signaling in Immune system Signaling by NOTCH RNA Polymerase II Transcription STAT3 Gene Information Basic Information Ensembl ID: ENSG00000168610 Description: signal transducer and activator of transcription 3 [Source:HGNC Symbol;Acc:HGNC:11364] Location: 17:42313324-42388568 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: cancer cell Other: Apoptosis Cytokine Signaling in Immune system Cellular responses to stress STAT5A Gene Information Basic Information Ensembl ID: ENSG00000126561 Description: signal transducer and activator of transcription 5A [Source:HGNC Symbol;Acc:HGNC:11366] Location: 17:42287547-42311943 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell CD4+ T cell adipocyte Other: Cytokine Signaling in Immune system Signaling by Leptin Signaling by Erythropoietin STAT5B Gene Information Basic Information Ensembl ID: ENSG00000173757 Description: signal transducer and activator of transcription 5B [Source:HGNC Symbol;Acc:HGNC:11367] Location: 17:42199176-42288633 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: trophoblast cell CD4+ T cell Other: Cytokine Signaling in Immune system Signaling by Leptin Signaling by Erythropoietin STAT6 Gene Information Basic Information Ensembl ID: ENSG00000166888 Description: signal transducer and activator of transcription 6 [Source:HGNC Symbol;Acc:HGNC:11368] Location: 12:57095408-57132139 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: secretory cell Other: Cytokine Signaling in Immune system Innate Immune System Signaling by Receptor Tyrosine Kinases THBS1 Gene Information Basic Information Ensembl ID: ENSG00000137801 Description: thrombospondin 1 [Source:HGNC Symbol;Acc:HGNC:11785] Location: 15:39581079-39599466 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell epithelial cell macrophage fibroblast phagocyte stromal cell smooth muscle cell monocyte neutrophil megakaryocyte pericyte Other: Diseases of glycosylation Integrin cell surface interactions Non-integrin membrane-ECM interactions TLR9 Gene Information Basic Information Ensembl ID: ENSG00000239732 Description: toll like receptor 9 [Source:HGNC Symbol;Acc:HGNC:15633] Location: 3:52221080-52225645 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Innate Immune System Signaling by Receptor Tyrosine Kinases Viral Infection Pathways VEGFA Gene Information Basic Information Ensembl ID: ENSG00000112715 Description: vascular endothelial growth factor A [Source:HGNC Symbol;Acc:HGNC:12680] Location: 6:43770184-43786487 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell macrophage epithelial cell stem cell monocyte fibroblast microglia pancreatic cell granulocyte secretory cell astrocyte dendritic cell endothelial cell Other: Cytokine Signaling in Immune system Cellular responses to stress RNA Polymerase II Transcription VEGFB Gene Information Basic Information Ensembl ID: ENSG00000173511 Description: vascular endothelial growth factor B [Source:HGNC Symbol;Acc:HGNC:12681] Location: 11:64234584-64239264 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endocrine cell dendritic cell fibroblast antigen presenting cell Other: Platelet activation, signaling and aggregation Signaling by Receptor Tyrosine Kinases VEGFC Gene Information Basic Information Ensembl ID: ENSG00000150630 Description: vascular endothelial growth factor C [Source:HGNC Symbol;Acc:HGNC:12682] Location: 4:176683538-176792922 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell smooth muscle cell lymphocyte Other: Platelet activation, signaling and aggregation Signaling by Receptor Tyrosine Kinases
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Pathway Hierarchies & Genes Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (1 genes) Signal Transduction Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Signaling by Rho GTPases RHO GTPase Effectors RHO GTPases activate PKNs Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 1 genes RHOBTB1 GTPase cycle (1 genes) Signal Transduction Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Signaling by Rho GTPases RHO GTPase cycle RHOBTB GTPase Cycle RHOBTB1 GTPase cycle 1 genes RAC1 GTPase cycle (3 genes) Signal Transduction Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Signaling by Rho GTPases RHO GTPase cycle RAC1 GTPase cycle 3 genes RHO GTPases Activate Formins (2 genes) Signal Transduction Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Signaling by Rho GTPases RHO GTPase Effectors RHO GTPases Activate Formins 2 genes RHO GTPases Activate NADPH Oxidases (2 genes) Signal Transduction Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Signaling by Rho GTPases RHO GTPase Effectors RHO GTPases Activate NADPH Oxidases 2 genes RHO GTPases Activate WASPs and WAVEs (4 genes) Signal Transduction Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Signaling by Rho GTPases RHO GTPase Effectors RHO GTPases Activate WASPs and WAVEs 4 genes RHO GTPases activate IQGAPs (2 genes) Signal Transduction Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Signaling by Rho GTPases RHO GTPase Effectors RHO GTPases activate IQGAPs 2 genes RHO GTPases activate PKNs (1 genes) Signal Transduction Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Signaling by Rho GTPases RHO GTPase Effectors RHO GTPases activate PKNs 1 genes RHOH GTPase cycle (2 genes) Signal Transduction Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Signaling by Rho GTPases RHO GTPase cycle RHOH GTPase cycle 2 genes RHOBTB3 ATPase cycle (1 genes) Signal Transduction Signaling by Rho GTPases, Miro GTPases and RHOBTB3 RHOBTB3 ATPase cycle 1 genes	ABL1 Gene Information Basic Information Ensembl ID: ENSG00000097007 Description: ABL proto-oncogene 1%2C non-receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:76] Location: 9:130713043-130887675 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Innate Immune System Epigenetic regulation of gene expression Myogenesis AR Gene Information Basic Information Ensembl ID: ENSG00000169083 Description: androgen receptor [Source:HGNC Symbol;Acc:HGNC:644] Location: X:67544021-67730619 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: fibroblast stromal cell epithelial cell adipocyte Other: Cellular responses to stress Post-translational protein modification RNA Polymerase II Transcription BIRC5 Gene Information Basic Information Ensembl ID: ENSG00000089685 Description: baculoviral IAP repeat containing 5 [Source:HGNC Symbol;Acc:HGNC:593] Location: 17:78214186-78225636 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell glial cell epithelial cell erythroid lineage cell progenitor cell cancer stem cell proliferative cell Other: Cytokine Signaling in Immune system Post-translational protein modification Cell Cycle, Mitotic BTK Gene Information Basic Information Ensembl ID: ENSG00000010671 Description: Bruton tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:1133] Location: X:101349338-101390796 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell Naive B cell mast cell granulocyte Other: Adaptive Immune System Innate Immune System Signaling by GPCR CCNE1 Gene Information Basic Information Ensembl ID: ENSG00000105173 Description: cyclin E1 [Source:HGNC Symbol;Acc:HGNC:1589] Location: 19:29811991-29824312 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: trophoblast cell Other: Cellular responses to stress Protein folding Synthesis of DNA CDC25C Gene Information Basic Information Ensembl ID: ENSG00000158402 Description: cell division cycle 25C [Source:HGNC Symbol;Acc:HGNC:1727] Location: 5:138285269-138338355 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cell Cycle, Mitotic Cell Cycle Checkpoints RNA Polymerase II Transcription CDH1 Gene Information Basic Information Ensembl ID: ENSG00000039068 Description: cadherin 1 [Source:HGNC Symbol;Acc:HGNC:1748] Location: 16:68737292-68835537 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: goblet cell epithelial cell pneumocyte stem cell secretory cell tuft cell paneth cell ciliated cell neuroendocrine cell brush cell basal cell serous cell deuterosomal cell club Other: Apoptosis Adaptive Immune System Degradation of the extracellular matrix CTNNB1 Gene Information Basic Information Ensembl ID: ENSG00000168036 Description: catenin beta 1 [Source:HGNC Symbol;Acc:HGNC:2514] Location: 3:41194741-41260096 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell endothelial cell epithelial cell stem cell phagocyte adrenal cortical cell fibroblast monocyte Specialized T cell melanocyte M cell Other: Apoptosis Innate Immune System Signaling by WNT EPHA2 Gene Information Basic Information Ensembl ID: ENSG00000142627 Description: EPH receptor A2 [Source:HGNC Symbol;Acc:HGNC:3386] Location: 1:16124337-16156069 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stem cell epithelial cell Other: Nervous system development Signaling by Rho GTPases, Miro GTPases and RHOBTB3 ITGB1 Gene Information Basic Information Ensembl ID: ENSG00000150093 Description: integrin subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:6153] Location: 10:32887273-33005792 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stellate cell pericyte trophoblast cell epithelial cell stromal cell stem cell endothelial cell smooth muscle cell fibroblast mesenchymal stem cell Other: Laminin interactions Cell surface interactions at the vascular wall Cytokine Signaling in Immune system JAG1 Gene Information Basic Information Ensembl ID: ENSG00000101384 Description: jagged canonical Notch ligand 1 [Source:HGNC Symbol;Acc:HGNC:6188] Location: 20:10637684-10673999 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell pericyte smooth muscle cell mural cell Other: Signaling by NOTCH RNA Polymerase II Transcription Signaling by Rho GTPases, Miro GTPases and RHOBTB3 LCK Gene Information Basic Information Ensembl ID: ENSG00000182866 Description: LCK proto-oncogene%2C Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6524] Location: 1:32251244-32286165 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell CD8+ T cell developing T cell T cell lymphocyte Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System MAPK1 Gene Information Basic Information Ensembl ID: ENSG00000100030 Description: mitogen-activated protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:6871] Location: 22:21759657-21867680 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Transmission across Chemical Synapses Signaling by NODAL MAPK14 Gene Information Basic Information Ensembl ID: ENSG00000112062 Description: mitogen-activated protein kinase 14 [Source:HGNC Symbol;Acc:HGNC:6876] Location: 6:36027752-36122511 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Platelet homeostasis Cytokine Signaling in Immune system Mitochondrial biogenesis MAPK3 Gene Information Basic Information Ensembl ID: ENSG00000102882 Description: mitogen-activated protein kinase 3 [Source:HGNC Symbol;Acc:HGNC:6877] Location: 16:30114105-30123506 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Transmission across Chemical Synapses Signaling by NODAL PIK3CA Gene Information Basic Information Ensembl ID: ENSG00000121879 Description: phosphatidylinositol-4%2C5-bisphosphate 3-kinase catalytic subunit alpha [Source:HGNC Symbol;Acc:HGNC:8975] Location: 3:179148114-179240093 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System PRKCA Gene Information Basic Information Ensembl ID: ENSG00000154229 Description: protein kinase C alpha [Source:HGNC Symbol;Acc:HGNC:9393] Location: 17:66302613-66810743 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: bipolar cell Other: Transmission across Chemical Synapses Integration of energy metabolism Signaling by WNT VIM Gene Information Basic Information Ensembl ID: ENSG00000026025 Description: vimentin [Source:HGNC Symbol;Acc:HGNC:12692] Location: 10:17228241-17237593 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell pericyte macrophage monocyte stem cell embryonic cell phagocyte fibroblast glial cell smooth muscle cell oligodendrocyte precursor cell bone cell mast cell granulocyte antigen presenting cell interstitial cell mesenchymal cell mesenchymal stem cell Other: Apoptosis Cytokine Signaling in Immune system Macroautophagy ZAP70 Gene Information Basic Information Ensembl ID: ENSG00000115085 Description: zeta chain of T cell receptor associated protein kinase 70 [Source:HGNC Symbol;Acc:HGNC:12858] Location: 2:97713576-97744327 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell developing T cell T cell CD8+ T cell Specialized T cell Other: Adaptive Immune System Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Signaling by ALK in cancer
Signaling by TGFB family members Pathway Hierarchies & Genes TGFBR3 expression (2 genes) Signal Transduction Signaling by TGFB family members Signaling by Activin Signaling by TGF-beta Receptor Complex TGF-beta receptor signaling activates SMADs Downregulation of TGF-beta receptor signaling 1 genes Signaling by TGFBR3 TGFBR3 expression 1 genes TGFBR3 regulates TGF-beta signaling (3 genes) Signal Transduction Signaling by TGFB family members Signaling by TGF-beta Receptor Complex TGF-beta receptor signaling activates SMADs Downregulation of TGF-beta receptor signaling Signaling by TGFBR3 TGFBR3 regulates TGF-beta signaling 3 genes Downregulation of SMAD2/3:SMAD4 transcriptional activity (3 genes) Signal Transduction Signaling by TGFB family members Signaling by Activin Signaling by TGF-beta Receptor Complex Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 1 genes Downregulation of SMAD2/3:SMAD4 transcriptional activity 2 genes TGFBR3 regulates TGF-beta signaling (7 genes) Signal Transduction Signaling by TGFB family members Signaling by TGF-beta Receptor Complex TGF-beta receptor signaling activates SMADs 6 genes Signaling by TGFBR3 TGFBR3 regulates TGF-beta signaling 1 genes SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (1 genes) Signal Transduction Signaling by TGFB family members Signaling by TGF-beta Receptor Complex Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 1 genes TGFBR3 expression (2 genes) Signal Transduction Signaling by TGFB family members Signaling by TGFBR3 TGFBR3 expression 2 genes TGFBR3 regulates FGF2 signaling (1 genes) Signal Transduction Signaling by TGFB family members Signaling by TGFBR3 TGFBR3 regulates FGF2 signaling 1 genes Signaling by BMP (1 genes) Signal Transduction Signaling by TGFB family members Signaling by BMP 1 genes	BMP2 Gene Information Basic Information Ensembl ID: ENSG00000125845 Description: bone morphogenetic protein 2 [Source:HGNC Symbol;Acc:HGNC:1069] Location: 20:6767686-6780246 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell osteoblast Other: Elastic fibre formation RNA Polymerase II Transcription Signaling by TGFB family members FGF2 Gene Information Basic Information Ensembl ID: ENSG00000138685 Description: fibroblast growth factor 2 [Source:HGNC Symbol;Acc:HGNC:3676] Location: 4:122826682-122898236 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: fibroblast glial cell adipocyte Other: Non-integrin membrane-ECM interactions Cytokine Signaling in Immune system Transcriptional regulation of pluripotent stem cells HELLS Gene Information Basic Information Ensembl ID: ENSG00000119969 Description: helicase%2C lymphoid specific [Source:HGNC Symbol;Acc:HGNC:4861] Location: 10:94545329-94613905 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: embryonic cell secretory cell mesenchymal stem cell Other: Signaling by TGFB family members ITGAV Gene Information Basic Information Ensembl ID: ENSG00000138448 Description: integrin subunit alpha V [Source:HGNC Symbol;Acc:HGNC:6150] Location: 2:186590010-186680901 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell glial cell stromal cell M cell endothelial cell Other: Adaptive Immune System Elastic fibre formation Innate Immune System ITGB1 Gene Information Basic Information Ensembl ID: ENSG00000150093 Description: integrin subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:6153] Location: 10:32887273-33005792 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stellate cell pericyte trophoblast cell epithelial cell stromal cell stem cell endothelial cell smooth muscle cell fibroblast mesenchymal stem cell Other: Laminin interactions Cell surface interactions at the vascular wall Cytokine Signaling in Immune system ITGB3 Gene Information Basic Information Ensembl ID: ENSG00000259207 Description: integrin subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:6156] Location: 17:47253827-47313743 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: platelet epithelial cell monocyte Other: ECM proteoglycans Elastic fibre formation Cell surface interactions at the vascular wall ITGB8 Gene Information Basic Information Ensembl ID: ENSG00000105855 Description: integrin subunit beta 8 [Source:HGNC Symbol;Acc:HGNC:6163] Location: 7:20330702-20415754 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell neuron pericyte embryonic cell trophoblast cell glial cell stromal cell schwann cell Other: Elastic fibre formation Integrin cell surface interactions Signaling by TGFB family members LTBP1 Gene Information Basic Information Ensembl ID: ENSG00000049323 Description: latent transforming growth factor beta binding protein 1 [Source:HGNC Symbol;Acc:HGNC:6714] Location: 2:32946953-33399509 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell endocrine cell pericyte epithelial cell fibroblast stromal cell smooth muscle cell cardiomyocyte muscle cell platelet interstitial cell progenitor cell dendritic cell glial cell erythroblast megakaryocyte Other: Elastic fibre formation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein modification MAPK1 Gene Information Basic Information Ensembl ID: ENSG00000100030 Description: mitogen-activated protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:6871] Location: 22:21759657-21867680 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Transmission across Chemical Synapses Signaling by NODAL MAPK3 Gene Information Basic Information Ensembl ID: ENSG00000102882 Description: mitogen-activated protein kinase 3 [Source:HGNC Symbol;Acc:HGNC:6877] Location: 16:30114105-30123506 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Transmission across Chemical Synapses Signaling by NODAL MYC Gene Information Basic Information Ensembl ID: ENSG00000136997 Description: MYC proto-oncogene%2C bHLH transcription factor [Source:HGNC Symbol;Acc:HGNC:7553] Location: 8:127735434-127742951 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte epithelial cell fibroblast stromal cell smooth muscle cell hematopoietic progenitor cell endothelial cell stem cell erythroblast muscle cell progenitor cell transient amplifying cell cancer stem cell B cell erythroid lineage cell Other: Cytokine Signaling in Immune system Signaling by NOTCH Signaling by WNT MYCN Gene Information Basic Information Ensembl ID: ENSG00000134323 Description: MYCN proto-oncogene%2C bHLH transcription factor [Source:HGNC Symbol;Acc:HGNC:7559] Location: 2:15940550-15947007 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell Other: Cell junction organization Signaling by Receptor Tyrosine Kinases Signaling by TGFB family members SMAD2 Gene Information Basic Information Ensembl ID: ENSG00000175387 Description: SMAD family member 2 [Source:HGNC Symbol;Acc:HGNC:6768] Location: 18:47808957-47931146 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Signaling by NODAL Transcriptional regulation of pluripotent stem cells Post-translational protein modification SMAD3 Gene Information Basic Information Ensembl ID: ENSG00000166949 Description: SMAD family member 3 [Source:HGNC Symbol;Acc:HGNC:6769] Location: 15:67063763-67195173 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell stem cell mesenchymal cell Other: Signaling by NODAL Cytokine Signaling in Immune system Signaling by NOTCH STAT1 Gene Information Basic Information Ensembl ID: ENSG00000115415 Description: signal transducer and activator of transcription 1 [Source:HGNC Symbol;Acc:HGNC:11362] Location: 2:190908460-191020960 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: dendritic cell Regulatory T cell CD8+ T cell leukocyte secretory cell monocyte epithelial cell Other: Cytokine Signaling in Immune system Signaling by NOTCH RNA Polymerase II Transcription TGFB1 Gene Information Basic Information Ensembl ID: ENSG00000105329 Description: transforming growth factor beta 1 [Source:HGNC Symbol;Acc:HGNC:11766] Location: 19:41301587-41353922 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell developing T cell T cell CD8+ T cell platelet Specialized T cell megakaryocyte Other: Platelet activation, signaling and aggregation RNA Polymerase II Transcription Cytokine Signaling in Immune system TGFB2 Gene Information Basic Information Ensembl ID: ENSG00000092969 Description: transforming growth factor beta 2 [Source:HGNC Symbol;Acc:HGNC:11768] Location: 1:218345336-218444619 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell Other: Elastic fibre formation ECM proteoglycans Platelet activation, signaling and aggregation TGFB3 Gene Information Basic Information Ensembl ID: ENSG00000119699 Description: transforming growth factor beta 3 [Source:HGNC Symbol;Acc:HGNC:11769] Location: 14:75958097-75983011 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte fibroblast Other: Elastic fibre formation ECM proteoglycans Platelet activation, signaling and aggregation TGFBR1 Gene Information Basic Information Ensembl ID: ENSG00000106799 Description: transforming growth factor beta receptor 1 [Source:HGNC Symbol;Acc:HGNC:11772] Location: 9:99104038-99154192 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: T cell phagocyte microglia Other: Post-translational protein modification Signaling by TGFB family members Signaling by TGF-beta Receptor Complex in Cancer TGFBR2 Gene Information Basic Information Ensembl ID: ENSG00000163513 Description: transforming growth factor beta receptor 2 [Source:HGNC Symbol;Acc:HGNC:11773] Location: 3:30606478-30694249 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell glial cell fibroblast Other: Post-translational protein modification Signaling by TGFB family members Signaling by TGF-beta Receptor Complex in Cancer
Signaling by WNT Pathway Hierarchies & Genes Ca2+ pathway (3 genes) Signal Transduction Signaling by WNT Degradation of beta-catenin by the destruction complex Repression of WNT target genes TCF dependent signaling in response to WNT Formation of the beta-catenin:TCF transactivating complex Binding of TCF/LEF:CTNNB1 to target gene promoters Beta-catenin independent WNT signaling Ca2+ pathway 3 genes Ca2+ pathway (2 genes) Signal Transduction Signaling by WNT Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade TCF dependent signaling in response to WNT Formation of the beta-catenin:TCF transactivating complex 1 genes Binding of TCF/LEF:CTNNB1 to target gene promoters Beta-catenin independent WNT signaling Ca2+ pathway 1 genes Asymmetric localization of PCP proteins (2 genes) Signal Transduction Signaling by WNT TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists 1 genes WNT ligand biogenesis and trafficking Beta-catenin independent WNT signaling PCP/CE pathway Asymmetric localization of PCP proteins 1 genes Asymmetric localization of PCP proteins (1 genes) Signal Transduction Signaling by WNT Beta-catenin independent WNT signaling PCP/CE pathway Asymmetric localization of PCP proteins 1 genes Binding of TCF/LEF:CTNNB1 to target gene promoters (1 genes) Signal Transduction Signaling by WNT TCF dependent signaling in response to WNT Formation of the beta-catenin:TCF transactivating complex Binding of TCF/LEF:CTNNB1 to target gene promoters 1 genes Ca2+ pathway (3 genes) Signal Transduction Signaling by WNT WNT ligand biogenesis and trafficking 2 genes Beta-catenin independent WNT signaling Ca2+ pathway 1 genes WNT5A-dependent internalization of FZD2, FZD5 and ROR2 (1 genes) Signal Transduction Signaling by WNT Beta-catenin independent WNT signaling PCP/CE pathway WNT5A-dependent internalization of FZD2, FZD5 and ROR2 1 genes WNT5A-dependent internalization of FZD4 (1 genes) Signal Transduction Signaling by WNT Beta-catenin independent WNT signaling PCP/CE pathway WNT5A-dependent internalization of FZD4 1 genes Ca2+ pathway (2 genes) Signal Transduction Signaling by WNT Beta-catenin independent WNT signaling Ca2+ pathway 2 genes Deactivation of the beta-catenin transactivating complex (4 genes) Signal Transduction Signaling by WNT TCF dependent signaling in response to WNT Deactivation of the beta-catenin transactivating complex 4 genes Formation of the beta-catenin:TCF transactivating complex (2 genes) Signal Transduction Signaling by WNT TCF dependent signaling in response to WNT Formation of the beta-catenin:TCF transactivating complex 2 genes WNT ligand biogenesis and trafficking (1 genes) Signal Transduction Signaling by WNT TCF dependent signaling in response to WNT WNT ligand biogenesis and trafficking 1 genes	AKT1 Gene Information Basic Information Ensembl ID: ENSG00000142208 Description: AKT serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:391] Location: 14:104769349-104795759 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Integrin signaling Apoptosis Cytokine Signaling in Immune system AKT2 Gene Information Basic Information Ensembl ID: ENSG00000105221 Description: AKT serine/threonine kinase 2 [Source:HGNC Symbol;Acc:HGNC:392] Location: 19:40230317-40285536 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: T cell Other: Apoptosis Cytokine Signaling in Immune system Adaptive Immune System APC Gene Information Basic Information Ensembl ID: ENSG00000134982 Description: APC regulator of WNT signaling pathway [Source:HGNC Symbol;Acc:HGNC:583] Location: 5:112707518-112846239 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: bergmann glial cell astrocyte bipolar cell Other: Apoptosis Signaling by WNT Post-translational protein modification CREBBP Gene Information Basic Information Ensembl ID: ENSG00000005339 Description: CREB binding protein [Source:HGNC Symbol;Acc:HGNC:2348] Location: 16:3725054-3880713 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes BMAL1:CLOCK,NPAS2 activates circadian expression CTNNB1 Gene Information Basic Information Ensembl ID: ENSG00000168036 Description: catenin beta 1 [Source:HGNC Symbol;Acc:HGNC:2514] Location: 3:41194741-41260096 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell endothelial cell epithelial cell stem cell phagocyte adrenal cortical cell fibroblast monocyte Specialized T cell melanocyte M cell Other: Apoptosis Innate Immune System Signaling by WNT DKK1 Gene Information Basic Information Ensembl ID: ENSG00000107984 Description: dickkopf WNT signaling pathway inhibitor 1 [Source:HGNC Symbol;Acc:HGNC:2891] Location: 10:52314281-52318042 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stromal cell Other: Signaling by WNT Transcriptional regulation of pluripotent stem cells Signaling by WNT in cancer FZD7 Gene Information Basic Information Ensembl ID: ENSG00000155760 Description: frizzled class receptor 7 [Source:HGNC Symbol;Acc:HGNC:4045] Location: 2:202033855-202038441 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Parasitic Infection Pathways Signaling by WNT Signaling by GPCR KRAS Gene Information Basic Information Ensembl ID: ENSG00000133703 Description: KRAS proto-oncogene%2C GTPase [Source:HGNC Symbol;Acc:HGNC:6407] Location: 12:25205246-25250936 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Signaling by Non-Receptor Tyrosine Kinases Transmission across Chemical Synapses Cytokine Signaling in Immune system LEF1 Gene Information Basic Information Ensembl ID: ENSG00000138795 Description: lymphoid enhancer binding factor 1 [Source:HGNC Symbol;Acc:HGNC:6551] Location: 4:108047545-108168956 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell developing T cell T cell Regulatory T cell Naive B cell CD4+ T cell lymphoid progenitor cell innate lymphoid cell Other: Signaling by WNT RNA Polymerase II Transcription Transcriptional regulation of granulopoiesis MYC Gene Information Basic Information Ensembl ID: ENSG00000136997 Description: MYC proto-oncogene%2C bHLH transcription factor [Source:HGNC Symbol;Acc:HGNC:7553] Location: 8:127735434-127742951 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte epithelial cell fibroblast stromal cell smooth muscle cell hematopoietic progenitor cell endothelial cell stem cell erythroblast muscle cell progenitor cell transient amplifying cell cancer stem cell B cell erythroid lineage cell Other: Cytokine Signaling in Immune system Signaling by NOTCH Signaling by WNT NFATC1 Gene Information Basic Information Ensembl ID: ENSG00000131196 Description: nuclear factor of activated T cells 1 [Source:HGNC Symbol;Acc:HGNC:7775] Location: 18:79395856-79529325 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell endocardial cell Other: Adaptive Immune System Innate Immune System Signaling by WNT PRKCA Gene Information Basic Information Ensembl ID: ENSG00000154229 Description: protein kinase C alpha [Source:HGNC Symbol;Acc:HGNC:9393] Location: 17:66302613-66810743 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: bipolar cell Other: Transmission across Chemical Synapses Integration of energy metabolism Signaling by WNT ROR1 Gene Information Basic Information Ensembl ID: ENSG00000185483 Description: receptor tyrosine kinase like orphan receptor 1 [Source:HGNC Symbol;Acc:HGNC:10256] Location: 1:63774017-64181498 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron endocrine cell pericyte epithelial cell glial cell stromal cell schwann cell Other: Signaling by WNT RUNX3 Gene Information Basic Information Ensembl ID: ENSG00000020633 Description: RUNX family transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:10473] Location: 1:24899511-24965121 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell developing T cell Specialized T cell CD8+ T cell progenitor cell T cell lymphocyte Other: Signaling by WNT RNA Polymerase II Transcription SMARCA4 Gene Information Basic Information Ensembl ID: ENSG00000127616 Description: SWI/SNF related%2C matrix associated%2C actin dependent regulator of chromatin%2C subfamily a%2C member 4 [Source:HGNC Symbol;Acc:HGNC:11100] Location: 19:10960932-11079426 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: Naive B cell epithelial cell fibroblast Other: Cytokine Signaling in Immune system Signaling by WNT Epigenetic regulation of gene expression SOX2 Gene Information Basic Information Ensembl ID: ENSG00000181449 Description: SRY-box transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:11195] Location: 3:181711925-181714436 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell pericyte progenitor cell embryonic cell fibroblast glial cell neural crest cell stem cell cancer stem cell ectodermal cell basal cell Other: Cytokine Signaling in Immune system Signaling by WNT Transcriptional regulation of pluripotent stem cells SOX9 Gene Information Basic Information Ensembl ID: ENSG00000125398 Description: SRY-box transcription factor 9 [Source:HGNC Symbol;Acc:HGNC:11204] Location: 17:72121020-72126416 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stem cell glial cell stromal cell tuft cell fibroblast ionocyte epithelial cell M cell chondrocyte cancer stem cell progenitor cell ductal cell Other: Signaling by WNT RNA Polymerase II Transcription Transcriptional regulation of testis differentiation TCF7 Gene Information Basic Information Ensembl ID: ENSG00000081059 Description: transcription factor 7 [Source:HGNC Symbol;Acc:HGNC:11639] Location: 5:134114681-134151865 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: memory T cell natural killer cell developing T cell T cell CD4+ T cell Specialized T cell innate lymphoid cell Other: Signaling by WNT RNA Polymerase II Transcription MITF-M-regulated melanocyte development WNT11 Gene Information Basic Information Ensembl ID: ENSG00000085741 Description: Wnt family member 11 [Source:HGNC Symbol;Acc:HGNC:12776] Location: 11:76186325-76210736 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Signaling by WNT Signaling by GPCR Kidney development WNT2 Gene Information Basic Information Ensembl ID: ENSG00000105989 Description: Wnt family member 2 [Source:HGNC Symbol;Acc:HGNC:12780] Location: 7:117275451-117323152 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: fibroblast stromal cell mesenchymal cell Other: Signaling by WNT Signaling by GPCR WNT3 Gene Information Basic Information Ensembl ID: ENSG00000108379 Description: Wnt family member 3 [Source:HGNC Symbol;Acc:HGNC:12782] Location: 17:46762506-46833154 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Signaling by WNT Signaling by GPCR WNT5A Gene Information Basic Information Ensembl ID: ENSG00000114251 Description: Wnt family member 5A [Source:HGNC Symbol;Acc:HGNC:12784] Location: 3:55465715-55490539 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: fibroblast mesenchymal cell Other: Signaling by WNT Membrane Trafficking Signaling by GPCR WNT7B Gene Information Basic Information Ensembl ID: ENSG00000188064 Description: Wnt family member 7B [Source:HGNC Symbol;Acc:HGNC:12787] Location: 22:45920366-45977162 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron Other: Signaling by WNT Signaling by GPCR
Smooth Muscle Contraction Pathway Hierarchies & Genes Smooth Muscle Contraction (1 genes) Muscle contraction Smooth Muscle Contraction 1 genes	ITGA1 Gene Information Basic Information Ensembl ID: ENSG00000213949 Description: integrin subunit alpha 1 [Source:HGNC Symbol;Acc:HGNC:6134] Location: 5:52787916-52959209 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell pericyte developing T cell epithelial cell fibroblast glial cell stromal cell Specialized T cell smooth muscle cell CD8+ T cell T cell mesenchymal cell lymphocyte beta cell memory T cell Other: Integrin cell surface interactions Laminin interactions Smooth Muscle Contraction
Specification of primordial germ cells Pathway Hierarchies & Genes Specification of primordial germ cells (1 genes) Reproduction Specification of primordial germ cells 1 genes	EOMES Gene Information Basic Information Ensembl ID: ENSG00000163508 Description: eomesodermin [Source:HGNC Symbol;Acc:HGNC:3372] Location: 3:27715949-27722711 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell Specialized T cell CD8+ T cell T cell progenitor cell mesodermal cell brush cell Other: Transcriptional regulation of pluripotent stem cells Cardiogenesis Gastrulation
Striated Muscle Contraction Pathway Hierarchies & Genes Striated Muscle Contraction (1 genes) Muscle contraction Striated Muscle Contraction 1 genes	VIM Gene Information Basic Information Ensembl ID: ENSG00000026025 Description: vimentin [Source:HGNC Symbol;Acc:HGNC:12692] Location: 10:17228241-17237593 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell pericyte macrophage monocyte stem cell embryonic cell phagocyte fibroblast glial cell smooth muscle cell oligodendrocyte precursor cell bone cell mast cell granulocyte antigen presenting cell interstitial cell mesenchymal cell mesenchymal stem cell Other: Apoptosis Cytokine Signaling in Immune system Macroautophagy
Surfactant metabolism Pathway Hierarchies & Genes Surfactant metabolism (3 genes) Metabolism of proteins Surfactant metabolism 3 genes	ADORA2A Gene Information Basic Information Ensembl ID: ENSG00000128271 Description: adenosine A2a receptor [Source:HGNC Symbol;Acc:HGNC:263] Location: 22:24417879-24442357 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Signaling by GPCR Surfactant metabolism Signaling by Receptor Tyrosine Kinases CSF2RA Gene Information Basic Information Ensembl ID: ENSG00000198223 Description: colony stimulating factor 2 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:2435] Location: X:1268793-1325373 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: neuron dendritic cell macrophage phagocyte microglia monocyte antigen presenting cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades Surfactant metabolism CSF2RB Gene Information Basic Information Ensembl ID: ENSG00000100368 Description: colony stimulating factor 2 receptor subunit beta [Source:HGNC Symbol;Acc:HGNC:2436] Location: 22:36913628-36940439 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell dendritic cell mast cell antigen presenting cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades Surfactant metabolism
Synthesis of DNA Pathway Hierarchies & Genes Orc1 removal from chromatin (1 genes) DNA Replication Synthesis of DNA DNA strand elongation Unwinding of DNA Switching of origins to a post-replicative state Orc1 removal from chromatin 1 genes CDK-mediated phosphorylation and removal of Cdc6 (1 genes) DNA Replication Synthesis of DNA Switching of origins to a post-replicative state CDK-mediated phosphorylation and removal of Cdc6 1 genes Orc1 removal from chromatin (1 genes) DNA Replication Synthesis of DNA Switching of origins to a post-replicative state Orc1 removal from chromatin 1 genes	CCNE1 Gene Information Basic Information Ensembl ID: ENSG00000105173 Description: cyclin E1 [Source:HGNC Symbol;Acc:HGNC:1589] Location: 19:29811991-29824312 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: trophoblast cell Other: Cellular responses to stress Protein folding Synthesis of DNA CDK2 Gene Information Basic Information Ensembl ID: ENSG00000123374 Description: cyclin dependent kinase 2 [Source:HGNC Symbol;Acc:HGNC:1771] Location: 12:55966781-55972789 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Meiosis Cellular responses to stress DNA Double-Strand Break Repair MCM2 Gene Information Basic Information Ensembl ID: ENSG00000073111 Description: minichromosome maintenance complex component 2 [Source:HGNC Symbol;Acc:HGNC:6944] Location: 3:127598223-127622436 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: DNA Replication Pre-Initiation Synthesis of DNA Cell Cycle, Mitotic
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Pathway Hierarchies & Genes The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex (1 genes) Circadian clock The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex 1 genes	CREBBP Gene Information Basic Information Ensembl ID: ENSG00000005339 Description: CREB binding protein [Source:HGNC Symbol;Acc:HGNC:2348] Location: 16:3725054-3880713 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes BMAL1:CLOCK,NPAS2 activates circadian expression
Transcriptional regulation of granulopoiesis Pathway Hierarchies & Genes Transcriptional regulation of granulopoiesis (9 genes) Developmental Biology Transcriptional regulation of granulopoiesis 9 genes	CDK2 Gene Information Basic Information Ensembl ID: ENSG00000123374 Description: cyclin dependent kinase 2 [Source:HGNC Symbol;Acc:HGNC:1771] Location: 12:55966781-55972789 (+) Biotype: protein_coding Species: Homo sapiens Annotations Other: Meiosis Cellular responses to stress DNA Double-Strand Break Repair CDK4 Gene Information Basic Information Ensembl ID: ENSG00000135446 Description: cyclin dependent kinase 4 [Source:HGNC Symbol;Acc:HGNC:1773] Location: 12:57747727-57756013 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: T cell schwann cell progenitor cell neural crest cell Other: Adipogenesis Meiosis Cellular responses to stress CDKN1A Gene Information Basic Information Ensembl ID: ENSG00000124762 Description: cyclin dependent kinase inhibitor 1A [Source:HGNC Symbol;Acc:HGNC:1784] Location: 6:36676460-36687397 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell pericyte dendritic cell smooth muscle cell fibroblast muscle cell monocyte Other: Cytokine Signaling in Immune system Cellular responses to stress Post-translational protein modification CSF3R Gene Information Basic Information Ensembl ID: ENSG00000119535 Description: colony stimulating factor 3 receptor [Source:HGNC Symbol;Acc:HGNC:2439] Location: 1:36466043-36483278 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: blood cell trophoblast cell phagocyte microglia granulocyte monocyte neutrophil myeloid cell Other: Cytokine Signaling in Immune system Transcriptional regulation of granulopoiesis E2F1 Gene Information Basic Information Ensembl ID: ENSG00000101412 Description: E2F transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:3113] Location: 20:33675477-33686385 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Signaling by NOTCH Cellular responses to stress IL6R Gene Information Basic Information Ensembl ID: ENSG00000160712 Description: interleukin 6 receptor [Source:HGNC Symbol;Acc:HGNC:6019] Location: 1:154405193-154469450 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: CD4+ T cell neutrophil Other: Cytokine Signaling in Immune system MAPK family signaling cascades Transcriptional regulation of granulopoiesis LEF1 Gene Information Basic Information Ensembl ID: ENSG00000138795 Description: lymphoid enhancer binding factor 1 [Source:HGNC Symbol;Acc:HGNC:6551] Location: 4:108047545-108168956 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: endothelial cell developing T cell T cell Regulatory T cell Naive B cell CD4+ T cell lymphoid progenitor cell innate lymphoid cell Other: Signaling by WNT RNA Polymerase II Transcription Transcriptional regulation of granulopoiesis MYC Gene Information Basic Information Ensembl ID: ENSG00000136997 Description: MYC proto-oncogene%2C bHLH transcription factor [Source:HGNC Symbol;Acc:HGNC:7553] Location: 8:127735434-127742951 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: pericyte epithelial cell fibroblast stromal cell smooth muscle cell hematopoietic progenitor cell endothelial cell stem cell erythroblast muscle cell progenitor cell transient amplifying cell cancer stem cell B cell erythroid lineage cell Other: Cytokine Signaling in Immune system Signaling by NOTCH Signaling by WNT STAT3 Gene Information Basic Information Ensembl ID: ENSG00000168610 Description: signal transducer and activator of transcription 3 [Source:HGNC Symbol;Acc:HGNC:11364] Location: 17:42313324-42388568 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: cancer cell Other: Apoptosis Cytokine Signaling in Immune system Cellular responses to stress
Transcriptional regulation of pluripotent stem cells Pathway Hierarchies & Genes POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation (5 genes) Developmental Biology Transcriptional regulation of pluripotent stem cells 1 genes POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 3 genes POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 1 genes POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation (1 genes) Developmental Biology Transcriptional regulation of pluripotent stem cells POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 1 genes	DKK1 Gene Information Basic Information Ensembl ID: ENSG00000107984 Description: dickkopf WNT signaling pathway inhibitor 1 [Source:HGNC Symbol;Acc:HGNC:2891] Location: 10:52314281-52318042 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stromal cell Other: Signaling by WNT Transcriptional regulation of pluripotent stem cells Signaling by WNT in cancer EOMES Gene Information Basic Information Ensembl ID: ENSG00000163508 Description: eomesodermin [Source:HGNC Symbol;Acc:HGNC:3372] Location: 3:27715949-27722711 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: natural killer cell Specialized T cell CD8+ T cell T cell progenitor cell mesodermal cell brush cell Other: Transcriptional regulation of pluripotent stem cells Cardiogenesis Gastrulation FGF2 Gene Information Basic Information Ensembl ID: ENSG00000138685 Description: fibroblast growth factor 2 [Source:HGNC Symbol;Acc:HGNC:3676] Location: 4:122826682-122898236 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: fibroblast glial cell adipocyte Other: Non-integrin membrane-ECM interactions Cytokine Signaling in Immune system Transcriptional regulation of pluripotent stem cells SMAD2 Gene Information Basic Information Ensembl ID: ENSG00000175387 Description: SMAD family member 2 [Source:HGNC Symbol;Acc:HGNC:6768] Location: 18:47808957-47931146 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Signaling by NODAL Transcriptional regulation of pluripotent stem cells Post-translational protein modification SOX2 Gene Information Basic Information Ensembl ID: ENSG00000181449 Description: SRY-box transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:11195] Location: 3:181711925-181714436 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell pericyte progenitor cell embryonic cell fibroblast glial cell neural crest cell stem cell cancer stem cell ectodermal cell basal cell Other: Cytokine Signaling in Immune system Signaling by WNT Transcriptional regulation of pluripotent stem cells STAT3 Gene Information Basic Information Ensembl ID: ENSG00000168610 Description: signal transducer and activator of transcription 3 [Source:HGNC Symbol;Acc:HGNC:11364] Location: 17:42313324-42388568 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: cancer cell Other: Apoptosis Cytokine Signaling in Immune system Cellular responses to stress
Transcriptional regulation of testis differentiation Pathway Hierarchies & Genes Transcriptional regulation of testis differentiation (2 genes) Developmental Biology Transcriptional regulation of testis differentiation 2 genes	SOX9 Gene Information Basic Information Ensembl ID: ENSG00000125398 Description: SRY-box transcription factor 9 [Source:HGNC Symbol;Acc:HGNC:11204] Location: 17:72121020-72126416 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: stem cell glial cell stromal cell tuft cell fibroblast ionocyte epithelial cell M cell chondrocyte cancer stem cell progenitor cell ductal cell Other: Signaling by WNT RNA Polymerase II Transcription Transcriptional regulation of testis differentiation WT1 Gene Information Basic Information Ensembl ID: ENSG00000184937 Description: WT1 transcription factor [Source:HGNC Symbol;Acc:HGNC:12796] Location: 11:32387775-32435564 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell stromal cell podocyte mesothelial cell Other: Cell junction organization Transcriptional regulation of testis differentiation Kidney development
Transmission across Chemical Synapses Pathway Hierarchies & Genes RSK activation (2 genes) Neuronal System Transmission across Chemical Synapses Neurotransmitter receptors and postsynaptic signal transmission Activation of NMDA receptors and postsynaptic events Post NMDA receptor activation events CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation 2 genes Ras activation upon Ca2+ influx through NMDA receptor (3 genes) Neuronal System Transmission across Chemical Synapses Neurotransmitter receptors and postsynaptic signal transmission Activation of NMDA receptors and postsynaptic events Post NMDA receptor activation events CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling Ras activation upon Ca2+ influx through NMDA receptor 3 genes Trafficking of GluR2-containing AMPA receptors (1 genes) Neuronal System Transmission across Chemical Synapses Neurotransmitter receptors and postsynaptic signal transmission Glutamate binding, activation of AMPA receptors and synaptic plasticity Trafficking of AMPA receptors Trafficking of GluR2-containing AMPA receptors 1 genes	HRAS Gene Information Basic Information Ensembl ID: ENSG00000174775 Description: HRas proto-oncogene%2C GTPase [Source:HGNC Symbol;Acc:HGNC:5173] Location: 11:532242-537321 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Transmission across Chemical Synapses Cytokine Signaling in Immune system Adaptive Immune System KRAS Gene Information Basic Information Ensembl ID: ENSG00000133703 Description: KRAS proto-oncogene%2C GTPase [Source:HGNC Symbol;Acc:HGNC:6407] Location: 12:25205246-25250936 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Signaling by Non-Receptor Tyrosine Kinases Transmission across Chemical Synapses Cytokine Signaling in Immune system MAPK1 Gene Information Basic Information Ensembl ID: ENSG00000100030 Description: mitogen-activated protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:6871] Location: 22:21759657-21867680 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Transmission across Chemical Synapses Signaling by NODAL MAPK3 Gene Information Basic Information Ensembl ID: ENSG00000102882 Description: mitogen-activated protein kinase 3 [Source:HGNC Symbol;Acc:HGNC:6877] Location: 16:30114105-30123506 (-) Biotype: protein_coding Species: Homo sapiens Annotations Other: Apoptosis Transmission across Chemical Synapses Signaling by NODAL NRAS Gene Information Basic Information Ensembl ID: ENSG00000213281 Description: NRAS proto-oncogene%2C GTPase [Source:HGNC Symbol;Acc:HGNC:7989] Location: 1:114704469-114716771 (-) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: epithelial cell cancer cell Other: Signaling by Erythropoietin Signaling by Non-Receptor Tyrosine Kinases Signaling by Nuclear Receptors PRKCA Gene Information Basic Information Ensembl ID: ENSG00000154229 Description: protein kinase C alpha [Source:HGNC Symbol;Acc:HGNC:9393] Location: 17:66302613-66810743 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: bipolar cell Other: Transmission across Chemical Synapses Integration of energy metabolism Signaling by WNT
Visual phototransduction Pathway Hierarchies & Genes Inactivation, recovery and regulation of the phototransduction cascade (1 genes) Sensory Perception Visual phototransduction The phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade 1 genes	PRKCA Gene Information Basic Information Ensembl ID: ENSG00000154229 Description: protein kinase C alpha [Source:HGNC Symbol;Acc:HGNC:9393] Location: 17:66302613-66810743 (+) Biotype: protein_coding Species: Homo sapiens Annotations Cell Type Markers: bipolar cell Other: Transmission across Chemical Synapses Integration of energy metabolism Signaling by WNT

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