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Name

Mouse Liver

#1211

Species

Mus musculus

# Genes

1000

# Serial Genes

Description

Highlights liver cell types and pathways.

Genes & Annotations

Reactome is a database of signaling and metabolic molecules organized into heirarchical pathways and relationships. Here we show the high level pathways, except 'Disease'. You can click on the pathway to see the full heirarchy and which levels are impacted by genes in the panel.

Annotation	Genes
ABC-family proteins mediated transport Pathway Hierarchies & Genes ABC transporters in lipid homeostasis (9 genes) Transport of small molecules ABC-family proteins mediated transport 5 genes ABC transporters in lipid homeostasis 4 genes	Abcc1 Gene Information Basic Information Ensembl ID: ENSMUSG00000023088 Description: ATP-binding cassette%2C sub-family C member 1 [Source:MGI Symbol;Acc:MGI:102676] Location: 16:14179422-14293601 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: ABC-family proteins mediated transport Metabolism of porphyrins Metabolism of vitamins and cofactors Abcc3 Gene Information Basic Information Ensembl ID: ENSMUSG00000020865 Description: ATP-binding cassette%2C sub-family C member 3 [Source:MGI Symbol;Acc:MGI:1923658] Location: 11:94234121-94283823 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Paracetamol ADME ABC-family proteins mediated transport Metabolism of lipids Abcc4 Gene Information Basic Information Ensembl ID: ENSMUSG00000032849 Description: ATP-binding cassette%2C sub-family C member 4 [Source:MGI Symbol;Acc:MGI:2443111] Location: 14:118720104-118943631 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell epithelial cell Other: ABC-family proteins mediated transport Platelet activation, signaling and aggregation Azathioprine ADME Abcc5 Gene Information Basic Information Ensembl ID: ENSMUSG00000022822 Description: ATP-binding cassette%2C sub-family C member 5 [Source:MGI Symbol;Acc:MGI:1351644] Location: 16:20150053-20245144 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: embryonic cell Other: ABC-family proteins mediated transport Metabolism of carbohydrates and carbohydrate derivatives Azathioprine ADME Abcd1 Gene Information Basic Information Ensembl ID: ENSMUSG00000031378 Description: ATP-binding cassette%2C sub-family D member 1 [Source:MGI Symbol;Acc:MGI:1349215] Location: X:72760203-72782140 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: ABC-family proteins mediated transport Metabolism of lipids Class I peroxisomal membrane protein import Abcd2 Gene Information Basic Information Ensembl ID: ENSMUSG00000055782 Description: ATP-binding cassette%2C sub-family D member 2 [Source:MGI Symbol;Acc:MGI:1349467] Location: 15:91030074-91076002 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: adipocyte Other: ABC-family proteins mediated transport Class I peroxisomal membrane protein import Abcg1 Gene Information Basic Information Ensembl ID: ENSMUSG00000024030 Description: ATP binding cassette subfamily G member 1 [Source:MGI Symbol;Acc:MGI:107704] Location: 17:31276649-31336962 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Plasma lipoprotein assembly, remodeling, and clearance ABC-family proteins mediated transport Abcg4 Gene Information Basic Information Ensembl ID: ENSMUSG00000032131 Description: ATP binding cassette subfamily G member 4 [Source:MGI Symbol;Acc:MGI:1890594] Location: 9:44184485-44199912 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: ABC-family proteins mediated transport Rnf185 Gene Information Basic Information Ensembl ID: ENSMUSG00000020448 Description: ring finger protein 185 [Source:MGI Symbol;Acc:MGI:1922078] Location: 11:3365982-3402363 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: ABC-family proteins mediated transport
ATP-dependent chromatin remodelers Pathway Hierarchies & Genes Formation of the embryonic stem cell BAF (esBAF) complex (1 genes) Chromatin organization ATP-dependent chromatin remodelers SWI/SNF chromatin remodelers Formation of the embryonic stem cell BAF (esBAF) complex 1 genes	Bcl11b Gene Information Basic Information Ensembl ID: ENSMUSG00000048251 Description: B cell leukemia/lymphoma 11B [Source:MGI Symbol;Acc:MGI:1929913] Location: 12:107876662-107969861 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell CD4+ T cell excitatory neuron T cell epithelial cell Other: ATP-dependent chromatin remodelers
Adaptive Immune System Pathway Hierarchies & Genes CD28 dependent Vav1 pathway (2 genes) Immune System Adaptive Immune System TCR signaling Generation of second messenger molecules 1 genes Regulation of T cell activation by CD28 family Co-stimulation by CD28 CD28 dependent Vav1 pathway 1 genes Co-inhibition by PD-1 (19 genes) Immune System Adaptive Immune System Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 18 genes TCR signaling Downstream TCR signaling Regulation of T cell activation by CD28 family Co-inhibition by PD-1 1 genes Downstream TCR signaling (1 genes) Immune System Adaptive Immune System Signaling by the B Cell Receptor (BCR) Downstream signaling events of B Cell Receptor (BCR) Activation of NF-kappaB in B cells TCR signaling Downstream TCR signaling 1 genes CD22 mediated BCR regulation (1 genes) Immune System Adaptive Immune System Regulation of T cell activation by CD28 family Co-inhibition by PD-1 Signaling by the B Cell Receptor (BCR) CD22 mediated BCR regulation 1 genes CD22 mediated BCR regulation (2 genes) Immune System Adaptive Immune System Regulation of T cell activation by CD28 family Co-stimulation by CD28 1 genes Signaling by the B Cell Receptor (BCR) CD22 mediated BCR regulation 1 genes CD28 dependent PI3K/Akt signaling (3 genes) Immune System Adaptive Immune System Regulation of T cell activation by CD28 family Co-stimulation by CD28 CD28 dependent PI3K/Akt signaling 3 genes CD28 dependent Vav1 pathway (1 genes) Immune System Adaptive Immune System Regulation of T cell activation by CD28 family Co-stimulation by CD28 CD28 dependent Vav1 pathway 1 genes Cross-presentation of particulate exogenous antigens (phagosomes) (4 genes) Immune System Adaptive Immune System Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Cross-presentation of particulate exogenous antigens (phagosomes) 4 genes Cross-presentation of soluble exogenous antigens (endosomes) (1 genes) Immune System Adaptive Immune System Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Cross-presentation of soluble exogenous antigens (endosomes) 1 genes ER-Phagosome pathway (1 genes) Immune System Adaptive Immune System Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation ER-Phagosome pathway 1 genes Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (3 genes) Immune System Adaptive Immune System Signaling by the B Cell Receptor (BCR) Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 3 genes Antigen processing: Ubiquitination & Proteasome degradation (14 genes) Immune System Adaptive Immune System Class I MHC mediated antigen processing & presentation Antigen processing: Ubiquitination & Proteasome degradation 14 genes Co-inhibition by CTLA4 (1 genes) Immune System Adaptive Immune System Regulation of T cell activation by CD28 family Co-inhibition by CTLA4 1 genes Downstream TCR signaling (3 genes) Immune System Adaptive Immune System TCR signaling Downstream TCR signaling 3 genes Phosphorylation of CD3 and TCR zeta chains (1 genes) Immune System Adaptive Immune System TCR signaling Phosphorylation of CD3 and TCR zeta chains 1 genes MHC class II antigen presentation (4 genes) Immune System Adaptive Immune System MHC class II antigen presentation 4 genes Rap1 signalling (1 genes) Immune System Adaptive Immune System Rap1 signalling 1 genes	Ap1s3 Gene Information Basic Information Ensembl ID: ENSMUSG00000054702 Description: adaptor-related protein complex AP-1%2C sigma 3 [Source:MGI Symbol;Acc:MGI:1891304] Location: 1:79584593-79649689 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell intercalated cell mast cell dendritic cell Other: Adaptive Immune System Membrane Trafficking Btk Gene Information Basic Information Ensembl ID: ENSMUSG00000031264 Description: Bruton agammaglobulinemia tyrosine kinase [Source:MGI Symbol;Acc:MGI:88216] Location: X:133443085-133484319 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Naive B cell Other: Adaptive Immune System Innate Immune System Signaling by GPCR Cbll1 Gene Information Basic Information Ensembl ID: ENSMUSG00000020659 Description: Casitas B-lineage lymphoma-like 1 [Source:MGI Symbol;Acc:MGI:2144842] Location: 12:31534828-31549615 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Adaptive Immune System Cell junction organization Cd200 Gene Information Basic Information Ensembl ID: ENSMUSG00000022661 Description: CD200 molecule [Source:MGI Symbol;Acc:MGI:1196990] Location: 16:45202498-45229416 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell glial cell smooth muscle cell Other: Adaptive Immune System Cd226 Gene Information Basic Information Ensembl ID: ENSMUSG00000034028 Description: CD226 antigen [Source:MGI Symbol;Acc:MGI:3039602] Location: 18:89195091-89290353 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell developing T cell T cell Specialized T cell Other: Adaptive Immune System Cd247 Gene Information Basic Information Ensembl ID: ENSMUSG00000005763 Description: CD247 antigen [Source:MGI Symbol;Acc:MGI:88334] Location: 1:165616250-165704846 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell developing T cell CD4+ T cell T cell hematopoietic cell Other: Adaptive Immune System Innate Immune System Cd28 Gene Information Basic Information Ensembl ID: ENSMUSG00000026012 Description: CD28 antigen [Source:MGI Symbol;Acc:MGI:88327] Location: 1:60755959-60812518 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell Regulatory T cell CD4+ T cell Specialized T cell T cell Other: Adaptive Immune System Intracellular signaling by second messengers Cd34 Gene Information Basic Information Ensembl ID: ENSMUSG00000016494 Description: CD34 antigen [Source:MGI Symbol;Acc:MGI:88329] Location: 1:194621127-194643587 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast endothelial cell stem cell hematopoietic stem cell eosinophil Other: Adaptive Immune System Cd8a Gene Information Basic Information Ensembl ID: ENSMUSG00000053977 Description: CD8 subunit alpha [Source:MGI Symbol;Acc:MGI:88346] Location: 6:71350411-71356157 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell CD8+ T cell Other: Adaptive Immune System Cd96 Gene Information Basic Information Ensembl ID: ENSMUSG00000022657 Description: CD96 antigen [Source:MGI Symbol;Acc:MGI:1934368] Location: 16:45856020-45940614 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell Specialized T cell Other: Adaptive Immune System Cdc42 Gene Information Basic Information Ensembl ID: ENSMUSG00000006699 Description: cell division cycle 42 [Source:MGI Symbol;Acc:MGI:106211] Location: 4:137047007-137085031 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: hematopoietic stem cell phagocyte antigen presenting cell macrophage dendritic cell Other: Adaptive Immune System Innate Immune System Signaling by GPCR Col1a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000001506 Description: collagen%2C type I%2C alpha 1 [Source:MGI Symbol;Acc:MGI:88467] Location: 11:94827050-94843868 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stellate cell pericyte stromal cell stem cell valve interstitial cell mesenchymal cell endothelial cell Other: ECM proteoglycans Platelet Adhesion to exposed collagen Adaptive Immune System Col1a2 Gene Information Basic Information Ensembl ID: ENSMUSG00000029661 Description: collagen%2C type I%2C alpha 2 [Source:MGI Symbol;Acc:MGI:88468] Location: 6:4504814-4541544 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stellate cell pericyte stem cell stromal cell epithelial cell vascular cell meningeal cell Other: Adaptive Immune System Degradation of the extracellular matrix Collagen formation Ctsh Gene Information Basic Information Ensembl ID: ENSMUSG00000032359 Description: cathepsin H [Source:MGI Symbol;Acc:MGI:107285] Location: 9:89936205-89958142 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte pneumocyte monocyte T cell myeloid progenitor cell Other: Adaptive Immune System Innate Immune System Surfactant metabolism Cxadr Gene Information Basic Information Ensembl ID: ENSMUSG00000022865 Description: coxsackie virus and adenovirus receptor [Source:MGI Symbol;Acc:MGI:1201679] Location: 16:78098377-78156662 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell fibroblast pneumocyte Other: Adaptive Immune System Cell surface interactions at the vascular wall Cybb Gene Information Basic Information Ensembl ID: ENSMUSG00000015340 Description: cytochrome b-245%2C beta polypeptide [Source:MGI Symbol;Acc:MGI:88574] Location: X:9301491-9354010 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: monocyte Other: Adaptive Immune System Innate Immune System Cellular responses to stress Dnm3 Gene Information Basic Information Ensembl ID: ENSMUSG00000040265 Description: dynamin 3 [Source:MGI Symbol;Acc:MGI:1341299] Location: 1:161810022-162305603 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Adaptive Immune System Innate Immune System Membrane Trafficking Fcgr1 Gene Information Basic Information Ensembl ID: ENSMUSG00000015947 Description: Fc receptor%2C IgG%2C high affinity I [Source:MGI Symbol;Acc:MGI:95498] Location: 3:96190225-96201285 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte antigen presenting cell macrophage dendritic cell monocyte hematopoietic cell neutrophil Other: Adaptive Immune System Innate Immune System Fyn Gene Information Basic Information Ensembl ID: ENSMUSG00000019843 Description: Fyn proto-oncogene [Source:MGI Symbol;Acc:MGI:95602] Location: 10:39244851-39441377 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cell surface interactions at the vascular wall Nephrin family interactions Cytokine Signaling in Immune system Icam1 Gene Information Basic Information Ensembl ID: ENSMUSG00000037405 Description: intercellular adhesion molecule 1 [Source:MGI Symbol;Acc:MGI:96392] Location: 9:20927281-20940113 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stem cell pneumocyte Other: Adaptive Immune System Integrin cell surface interactions Itga4 Gene Information Basic Information Ensembl ID: ENSMUSG00000027009 Description: integrin alpha 4 [Source:MGI Symbol;Acc:MGI:96603] Location: 2:79085770-79163467 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell Regulatory T cell CD8+ T cell monocyte T cell Specialized T cell Other: Adaptive Immune System Cell surface interactions at the vascular wall Integrin cell surface interactions Itgal Gene Information Basic Information Ensembl ID: ENSMUSG00000030830 Description: integrin alpha L [Source:MGI Symbol;Acc:MGI:96606] Location: 7:126895432-126934310 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell CD4+ T cell CD8+ T cell monocyte Specialized T cell Other: Adaptive Immune System Innate Immune System Cell surface interactions at the vascular wall Itgav Gene Information Basic Information Ensembl ID: ENSMUSG00000027087 Description: integrin alpha V [Source:MGI Symbol;Acc:MGI:96608] Location: 2:83554741-83637260 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell bone cell Other: ECM proteoglycans Non-integrin membrane-ECM interactions Adaptive Immune System Itgb2 Gene Information Basic Information Ensembl ID: ENSMUSG00000000290 Description: integrin beta 2 [Source:MGI Symbol;Acc:MGI:96611] Location: 10:77366086-77401542 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell monocyte neutrophil Other: Adaptive Immune System Innate Immune System Cell surface interactions at the vascular wall Kif16b Gene Information Basic Information Ensembl ID: ENSMUSG00000038844 Description: kinesin family member 16B [Source:MGI Symbol;Acc:MGI:1098240] Location: 2:142459394-142743451 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Adaptive Immune System Membrane Trafficking Factors involved in megakaryocyte development and platelet production Lyn Gene Information Basic Information Ensembl ID: ENSMUSG00000042228 Description: LYN proto-oncogene%2C Src family tyrosine kinase [Source:MGI Symbol;Acc:MGI:96892] Location: 4:3678115-3813122 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Platelet Adhesion to exposed collagen Cytokine Signaling in Immune system Adaptive Immune System Map3k7 Gene Information Basic Information Ensembl ID: ENSMUSG00000028284 Description: mitogen-activated protein kinase kinase kinase 7 [Source:MGI Symbol;Acc:MGI:1346877] Location: 4:31964097-32023467 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Mylip Gene Information Basic Information Ensembl ID: ENSMUSG00000038175 Description: myosin regulatory light chain interacting protein [Source:MGI Symbol;Acc:MGI:2388271] Location: 13:45543218-45565498 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell microglia Other: Adaptive Immune System Plasma lipoprotein assembly, remodeling, and clearance Ncf1 Gene Information Basic Information Ensembl ID: ENSMUSG00000015950 Description: neutrophil cytosolic factor 1 [Source:MGI Symbol;Acc:MGI:97283] Location: 5:134248907-134258479 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell hematopoietic stem cell phagocyte granulocyte Other: Adaptive Immune System Innate Immune System Cellular responses to stress Ncf4 Gene Information Basic Information Ensembl ID: ENSMUSG00000071715 Description: neutrophil cytosolic factor 4 [Source:MGI Symbol;Acc:MGI:109186] Location: 15:78129001-78146780 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell dendritic cell erythrocyte granulocyte monocyte Other: Adaptive Immune System Innate Immune System Cellular responses to stress Pak1 Gene Information Basic Information Ensembl ID: ENSMUSG00000030774 Description: p21 (RAC1) activated kinase 1 [Source:MGI Symbol;Acc:MGI:1339975] Location: 7:97437748-97561588 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell epithelial cell excitatory neuron Other: Adaptive Immune System Innate Immune System Signaling by GPCR Plcg1 Gene Information Basic Information Ensembl ID: ENSMUSG00000016933 Description: phospholipase C%2C gamma 1 [Source:MGI Symbol;Acc:MGI:97615] Location: 2:160573220-160617680 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Inositol phosphate metabolism Ppp2ca Gene Information Basic Information Ensembl ID: ENSMUSG00000020349 Description: protein phosphatase 2 (formerly 2A)%2C catalytic subunit%2C alpha isoform [Source:MGI Symbol;Acc:MGI:1321159] Location: 11:51989508-52018605 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Prkn Gene Information Basic Information Ensembl ID: ENSMUSG00000023826 Description: parkin RBR E3 ubiquitin protein ligase [Source:MGI Symbol;Acc:MGI:1355296] Location: 17:11059271-12282248 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Adaptive Immune System Macroautophagy Regulated Necrosis Prr5 Gene Information Basic Information Ensembl ID: ENSMUSG00000036106 Description: proline rich 5 (renal) [Source:MGI Symbol;Acc:MGI:1924714] Location: 15:84553821-84587874 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: plasma cell Other: Adaptive Immune System RNA Polymerase II Transcription Intracellular signaling by second messengers Ptpn11 Gene Information Basic Information Ensembl ID: ENSMUSG00000043733 Description: protein tyrosine phosphatase%2C non-receptor type 11 [Source:MGI Symbol;Acc:MGI:99511] Location: 5:121268596-121329460 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Nervous system development Cytokine Signaling in Immune system Adaptive Immune System Ptpn22 Gene Information Basic Information Ensembl ID: ENSMUSG00000027843 Description: protein tyrosine phosphatase%2C non-receptor type 22 (lymphoid) [Source:MGI Symbol;Acc:MGI:107170] Location: 3:103767111-103819563 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell developing T cell CD4+ T cell leukocyte Specialized T cell T cell lymphocyte Other: Adaptive Immune System Ptpn6 Gene Information Basic Information Ensembl ID: ENSMUSG00000004266 Description: protein tyrosine phosphatase%2C non-receptor type 6 [Source:MGI Symbol;Acc:MGI:96055] Location: 6:124697670-124715677 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell Naive B cell tuft cell monocyte dendritic cell macrophage Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Pvr Gene Information Basic Information Ensembl ID: ENSMUSG00000040511 Description: poliovirus receptor [Source:MGI Symbol;Acc:MGI:107741] Location: 7:19637503-19655085 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Adaptive Immune System Cell junction organization Rap1gap Gene Information Basic Information Ensembl ID: ENSMUSG00000041351 Description: Rap1 GTPase-activating protein [Source:MGI Symbol;Acc:MGI:109338] Location: 4:137392037-137457172 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pancreatic cell oligodendrocyte precursor cell Other: Adaptive Immune System Nervous system development Rela Gene Information Basic Information Ensembl ID: ENSMUSG00000024927 Description: v-rel reticuloendotheliosis viral oncogene homolog A (avian) [Source:MGI Symbol;Acc:MGI:103290] Location: 19:5687511-5698158 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Ripk2 Gene Information Basic Information Ensembl ID: ENSMUSG00000041135 Description: receptor (TNFRSF)-interacting serine-threonine kinase 2 [Source:MGI Symbol;Acc:MGI:1891456] Location: 4:16122733-16163647 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Rnf130 Gene Information Basic Information Ensembl ID: ENSMUSG00000020376 Description: ring finger protein 130 [Source:MGI Symbol;Acc:MGI:1891717] Location: 11:49916173-50016546 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte basophil monocyte Other: Adaptive Immune System Rnf41 Gene Information Basic Information Ensembl ID: ENSMUSG00000025373 Description: ring finger protein 41 [Source:MGI Symbol;Acc:MGI:1914838] Location: 10:128247526-128277310 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Adaptive Immune System Signaling by Receptor Tyrosine Kinases Siglec1 Gene Information Basic Information Ensembl ID: ENSMUSG00000027322 Description: sialic acid binding Ig-like lectin 1%2C sialoadhesin [Source:MGI Symbol;Acc:MGI:99668] Location: 2:130911140-130928685 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: macrophage Other: Adaptive Immune System Siglece Gene Information Basic Information Ensembl ID: ENSMUSG00000030474 Description: sialic acid binding Ig-like lectin E [Source:MGI Symbol;Acc:MGI:1932475] Location: 7:43300494-43309585 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell neutrophil Other: Adaptive Immune System Innate Immune System Slamf7 Gene Information Basic Information Ensembl ID: ENSMUSG00000038179 Description: SLAM family member 7 [Source:MGI Symbol;Acc:MGI:1922595] Location: 1:171459971-171480603 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell phagocyte Naive B cell dendritic cell plasma cell Other: Adaptive Immune System Smurf1 Gene Information Basic Information Ensembl ID: ENSMUSG00000038780 Description: SMAD specific E3 ubiquitin protein ligase 1 [Source:MGI Symbol;Acc:MGI:1923038] Location: 5:144813305-144902657 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Adaptive Immune System Signaling by WNT Signaling by Hedgehog Smurf2 Gene Information Basic Information Ensembl ID: ENSMUSG00000018363 Description: SMAD specific E3 ubiquitin protein ligase 2 [Source:MGI Symbol;Acc:MGI:1913563] Location: 11:106710892-106811541 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Adaptive Immune System Signaling by WNT Signaling by Hedgehog Socs1 Gene Information Basic Information Ensembl ID: ENSMUSG00000038037 Description: suppressor of cytokine signaling 1 [Source:MGI Symbol;Acc:MGI:1354910] Location: 16:10600104-10603400 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell innate lymphoid cell Other: Cytokine Signaling in Immune system Adaptive Immune System Sos1 Gene Information Basic Information Ensembl ID: ENSMUSG00000024241 Description: SOS Ras/Rac guanine nucleotide exchange factor 1 [Source:MGI Symbol;Acc:MGI:98354] Location: 17:80701180-80787882 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Spsb4 Gene Information Basic Information Ensembl ID: ENSMUSG00000046997 Description: splA/ryanodine receptor domain and SOCS box containing 4 [Source:MGI Symbol;Acc:MGI:2183445] Location: 9:96825535-96900896 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: progenitor cell Other: Post-translational protein modification Adaptive Immune System Stub1 Gene Information Basic Information Ensembl ID: ENSMUSG00000039615 Description: STIP1 homology and U-Box containing protein 1 [Source:MGI Symbol;Acc:MGI:1891731] Location: 17:26049479-26052378 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Adaptive Immune System Regulated Necrosis RNA Polymerase II Transcription Syk Gene Information Basic Information Ensembl ID: ENSMUSG00000021457 Description: spleen tyrosine kinase [Source:MGI Symbol;Acc:MGI:99515] Location: 13:52737209-52802828 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell Naive B cell monocyte granulocyte Other: Integrin signaling Cytokine Signaling in Immune system Adaptive Immune System Tap1 Gene Information Basic Information Ensembl ID: ENSMUSG00000037321 Description: transporter 1%2C ATP-binding cassette%2C sub-family B (MDR/TAP) [Source:MGI Symbol;Acc:MGI:98483] Location: 17:34406527-34416199 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Adaptive Immune System Traf6 Gene Information Basic Information Ensembl ID: ENSMUSG00000027164 Description: TNF receptor-associated factor 6 [Source:MGI Symbol;Acc:MGI:108072] Location: 2:101508774-101532014 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Post-translational protein modification Cytokine Signaling in Immune system Adaptive Immune System Trem1 Gene Information Basic Information Ensembl ID: ENSMUSG00000042265 Description: triggering receptor expressed on myeloid cells 1 [Source:MGI Symbol;Acc:MGI:1930005] Location: 17:48539796-48553952 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell granulocyte monocyte Other: Adaptive Immune System Innate Immune System Cell surface interactions at the vascular wall Trim32 Gene Information Basic Information Ensembl ID: ENSMUSG00000051675 Description: tripartite motif-containing 32 [Source:MGI Symbol;Acc:MGI:1917057] Location: 4:65523223-65534475 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Adaptive Immune System Innate Immune System Trim37 Gene Information Basic Information Ensembl ID: ENSMUSG00000018548 Description: tripartite motif-containing 37 [Source:MGI Symbol;Acc:MGI:2153072] Location: 11:87017903-87111509 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron endothelial cell Other: Adaptive Immune System Trim41 Gene Information Basic Information Ensembl ID: ENSMUSG00000040365 Description: tripartite motif-containing 41 [Source:MGI Symbol;Acc:MGI:2384814] Location: 11:48697231-48708180 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Adaptive Immune System Ube2g2 Gene Information Basic Information Ensembl ID: ENSMUSG00000009293 Description: ubiquitin-conjugating enzyme E2G 2 [Source:MGI Symbol;Acc:MGI:1343188] Location: 10:77458109-77481827 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Adaptive Immune System Post-translational protein modification Vcam1 Gene Information Basic Information Ensembl ID: ENSMUSG00000027962 Description: vascular cell adhesion molecule 1 [Source:MGI Symbol;Acc:MGI:98926] Location: 3:115903598-115923337 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell fibroblast phagocyte stem cell stromal cell muscle cell macrophage kupffer cell Other: Adaptive Immune System Integrin cell surface interactions
Aerobic respiration and respiratory electron transport Pathway Hierarchies & Genes The fatty acid cycling model (1 genes) Metabolism Aerobic respiration and respiratory electron transport Mitochondrial Uncoupling The fatty acid cycling model 1 genes	Ucp2 Gene Information Basic Information Ensembl ID: ENSMUSG00000033685 Description: uncoupling protein 2 (mitochondrial%2C proton carrier) [Source:MGI Symbol;Acc:MGI:109354] Location: 7:100142544-100151227 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Aerobic respiration and respiratory electron transport
Apoptosis Pathway Hierarchies & Genes Caspase activation via Dependence Receptors in the absence of ligand (1 genes) Programmed Cell Death Apoptosis Intrinsic Pathway for Apoptosis Apoptotic factor-mediated response Cytochrome c-mediated apoptotic response Activation of caspases through apoptosome-mediated cleavage Apoptotic execution phase Apoptotic cleavage of cellular proteins Caspase-mediated cleavage of cytoskeletal proteins Caspase activation via extrinsic apoptotic signalling pathway Caspase activation via Dependence Receptors in the absence of ligand 1 genes Regulation by c-FLIP (2 genes) Programmed Cell Death Apoptosis Intrinsic Pathway for Apoptosis Activation, myristolyation of BID and translocation to mitochondria 1 genes Apoptotic execution phase Apoptotic cleavage of cellular proteins Caspase-mediated cleavage of cytoskeletal proteins Caspase activation via extrinsic apoptotic signalling pathway Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP 1 genes Activation of BAD and translocation to mitochondria (2 genes) Programmed Cell Death Apoptosis Intrinsic Pathway for Apoptosis Activation of BH3-only proteins Activation of BAD and translocation to mitochondria 2 genes Activation of BIM and translocation to mitochondria (2 genes) Programmed Cell Death Apoptosis Intrinsic Pathway for Apoptosis Activation of BH3-only proteins Activation of BIM and translocation to mitochondria 2 genes Activation of NOXA and translocation to mitochondria (1 genes) Programmed Cell Death Apoptosis Intrinsic Pathway for Apoptosis Activation of BH3-only proteins Activation of NOXA and translocation to mitochondria 1 genes Apoptotic cleavage of cell adhesion proteins (5 genes) Programmed Cell Death Apoptosis Apoptotic execution phase Apoptotic cleavage of cellular proteins Apoptotic cleavage of cell adhesion proteins 5 genes Caspase-mediated cleavage of cytoskeletal proteins (1 genes) Programmed Cell Death Apoptosis Apoptotic execution phase Apoptotic cleavage of cellular proteins Caspase-mediated cleavage of cytoskeletal proteins 1 genes Regulation by c-FLIP (6 genes) Programmed Cell Death Apoptosis Caspase activation via extrinsic apoptotic signalling pathway Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP 6 genes Caspase activation via Death Receptors in the presence of ligand (3 genes) Programmed Cell Death Apoptosis Caspase activation via extrinsic apoptotic signalling pathway Caspase activation via Death Receptors in the presence of ligand 3 genes Caspase activation via Dependence Receptors in the absence of ligand (1 genes) Programmed Cell Death Apoptosis Caspase activation via extrinsic apoptotic signalling pathway Caspase activation via Dependence Receptors in the absence of ligand 1 genes	Appl1 Gene Information Basic Information Ensembl ID: ENSMUSG00000040760 Description: adaptor protein%2C phosphotyrosine interaction%2C PH domain and leucine zipper containing 1 [Source:MGI Symbol;Acc:MGI:1920243] Location: 14:26640945-26693189 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Apoptosis Bcl2 Gene Information Basic Information Ensembl ID: ENSMUSG00000057329 Description: B cell leukemia/lymphoma 2 [Source:MGI Symbol;Acc:MGI:88138] Location: 1:106465908-106642004 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Apoptosis Innate Immune System Bcl2l11 Gene Information Basic Information Ensembl ID: ENSMUSG00000027381 Description: BCL2 like 11 [Source:MGI Symbol;Acc:MGI:1197519] Location: 2:127967958-128004467 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Apoptosis Death Receptor Signaling Bid Gene Information Basic Information Ensembl ID: ENSMUSG00000004446 Description: BH3 interacting domain death agonist [Source:MGI Symbol;Acc:MGI:108093] Location: 6:120868891-120893814 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Apoptosis Casp3 Gene Information Basic Information Ensembl ID: ENSMUSG00000031628 Description: caspase 3 [Source:MGI Symbol;Acc:MGI:107739] Location: 8:47070326-47092724 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell eosinophil Other: Apoptosis Cytokine Signaling in Immune system Signaling by Hippo Casp8 Gene Information Basic Information Ensembl ID: ENSMUSG00000026029 Description: caspase 8 [Source:MGI Symbol;Acc:MGI:1261423] Location: 1:58834533-58886662 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System Ctnnb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000006932 Description: catenin beta 1 [Source:MGI Symbol;Acc:MGI:88276] Location: 9:120758282-120789573 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stem cell epithelial cell Other: Apoptosis Innate Immune System Signaling by WNT Dsg2 Gene Information Basic Information Ensembl ID: ENSMUSG00000044393 Description: desmoglein 2 [Source:MGI Symbol;Acc:MGI:1196466] Location: 18:20691131-20737578 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell tuft cell epithelial cell Other: Apoptosis Keratinization Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Dsp Gene Information Basic Information Ensembl ID: ENSMUSG00000054889 Description: desmoplakin [Source:MGI Symbol;Acc:MGI:109611] Location: 13:38335270-38382553 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell tuft cell skeletal muscle cell basal cell Other: Apoptosis Innate Immune System Keratinization Fadd Gene Information Basic Information Ensembl ID: ENSMUSG00000031077 Description: Fas associated via death domain [Source:MGI Symbol;Acc:MGI:109324] Location: 7:144131055-144136200 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Apoptosis Innate Immune System Regulated Necrosis Fasl Gene Information Basic Information Ensembl ID: ENSMUSG00000000817 Description: Fas ligand [Source:MGI Symbol;Acc:MGI:99255] Location: 1:161608258-161616064 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell CD8+ T cell T cell Other: Apoptosis Regulated Necrosis Death Receptor Signaling Gzmb Gene Information Basic Information Ensembl ID: ENSMUSG00000015437 Description: granzyme B [Source:MGI Symbol;Acc:MGI:109267] Location: 14:56496295-56499717 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell CD8+ T cell Other: Apoptosis Regulated Necrosis Mapk8 Gene Information Basic Information Ensembl ID: ENSMUSG00000021936 Description: mitogen-activated protein kinase 8 [Source:MGI Symbol;Acc:MGI:1346861] Location: 14:33099855-33169115 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System Mapt Gene Information Basic Information Ensembl ID: ENSMUSG00000018411 Description: microtubule-associated protein tau [Source:MGI Symbol;Acc:MGI:97180] Location: 11:104122216-104222916 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron pericyte epithelial cell skeletal muscle cell Other: Apoptosis Cytokine Signaling in Immune system Pmaip1 Gene Information Basic Information Ensembl ID: ENSMUSG00000024521 Description: phorbol-12-myristate-13-acetate-induced protein 1 [Source:MGI Symbol;Acc:MGI:1930146] Location: 18:66591604-66598636 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Apoptosis Ripk1 Gene Information Basic Information Ensembl ID: ENSMUSG00000021408 Description: receptor (TNFRSF)-interacting serine-threonine kinase 1 [Source:MGI Symbol;Acc:MGI:108212] Location: 13:34186346-34221130 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Apoptosis Innate Immune System Regulated Necrosis Ticam1 Gene Information Basic Information Ensembl ID: ENSMUSG00000047123 Description: TIR domain containing adaptor molecule 1 [Source:MGI Symbol;Acc:MGI:2147032] Location: 17:56576319-56583786 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Apoptosis Innate Immune System Ticam2 Gene Information Basic Information Ensembl ID: ENSMUSG00000056130 Description: TIR domain containing adaptor molecule 2 [Source:MGI Symbol;Acc:MGI:3040056] Location: 18:46690358-46707600 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Apoptosis Innate Immune System Tjp1 Gene Information Basic Information Ensembl ID: ENSMUSG00000030516 Description: tight junction protein 1 [Source:MGI Symbol;Acc:MGI:98759] Location: 7:64945913-65177529 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell epithelial cell Other: Apoptosis Membrane Trafficking Signaling by Hippo Tjp2 Gene Information Basic Information Ensembl ID: ENSMUSG00000024812 Description: tight junction protein 2 [Source:MGI Symbol;Acc:MGI:1341872] Location: 19:24071869-24202394 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron epithelial cell Other: Apoptosis Signaling by Hippo Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Tlr4 Gene Information Basic Information Ensembl ID: ENSMUSG00000039005 Description: toll-like receptor 4 [Source:MGI Symbol;Acc:MGI:96824] Location: 4:66745821-66848521 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte Other: Apoptosis Innate Immune System Cellular responses to stress Tnfrsf10b Gene Information Basic Information Ensembl ID: ENSMUSG00000022074 Description: tumor necrosis factor receptor superfamily%2C member 10b [Source:MGI Symbol;Acc:MGI:1341090] Location: 14:70004921-70021860 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Apoptosis Cell surface interactions at the vascular wall Regulated Necrosis Tnfsf10 Gene Information Basic Information Ensembl ID: ENSMUSG00000039304 Description: tumor necrosis factor (ligand) superfamily%2C member 10 [Source:MGI Symbol;Acc:MGI:107414] Location: 3:27371177-27396576 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Apoptosis Regulated Necrosis Death Receptor Signaling Traf2 Gene Information Basic Information Ensembl ID: ENSMUSG00000026942 Description: TNF receptor-associated factor 2 [Source:MGI Symbol;Acc:MGI:101835] Location: 2:25407994-25436952 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System
Aquaporin-mediated transport Pathway Hierarchies & Genes Passive transport by Aquaporins (3 genes) Transport of small molecules Aquaporin-mediated transport Vasopressin regulates renal water homeostasis via Aquaporins 1 genes Passive transport by Aquaporins 2 genes Passive transport by Aquaporins (1 genes) Transport of small molecules Aquaporin-mediated transport Transport of glycerol from adipocytes to the liver by Aquaporins Passive transport by Aquaporins 1 genes	Aqp1 Gene Information Basic Information Ensembl ID: ENSMUSG00000004655 Description: aquaporin 1 [Source:MGI Symbol;Acc:MGI:103201] Location: 6:55313417-55325540 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell hematopoietic progenitor cell erythroblast podocyte Other: O2/CO2 exchange in erythrocytes Aquaporin-mediated transport Aqp4 Gene Information Basic Information Ensembl ID: ENSMUSG00000024411 Description: aquaporin 4 [Source:MGI Symbol;Acc:MGI:107387] Location: 18:15522553-15544039 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell stem cell glial cell astrocyte Other: Aquaporin-mediated transport Aqp7 Gene Information Basic Information Ensembl ID: ENSMUSG00000028427 Description: aquaporin 7 [Source:MGI Symbol;Acc:MGI:1314647] Location: 4:41033074-41048139 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Aquaporin-mediated transport Gngt2 Gene Information Basic Information Ensembl ID: ENSMUSG00000038811 Description: guanine nucleotide binding protein (G protein)%2C gamma transducing activity polypeptide 2 [Source:MGI Symbol;Acc:MGI:893584] Location: 11:95728042-95736560 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell dendritic cell phagocyte monocyte myeloid cell plasma cell macrophage photoreceptor cell Other: Platelet homeostasis Transmission across Chemical Synapses Potassium Channels
Aspirin ADME Pathway Hierarchies & Genes Aspirin ADME (3 genes) Drug ADME Aspirin ADME 3 genes	Abcc3 Gene Information Basic Information Ensembl ID: ENSMUSG00000020865 Description: ATP-binding cassette%2C sub-family C member 3 [Source:MGI Symbol;Acc:MGI:1923658] Location: 11:94234121-94283823 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Paracetamol ADME ABC-family proteins mediated transport Metabolism of lipids Slc22a7 Gene Information Basic Information Ensembl ID: ENSMUSG00000067144 Description: solute carrier family 22 (organic anion transporter)%2C member 7 [Source:MGI Symbol;Acc:MGI:1859559] Location: 17:46743109-46749383 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: tuft cell Other: SLC-mediated transmembrane transport Aspirin ADME Ugt2b34 Gene Information Basic Information Ensembl ID: ENSMUSG00000029260 Description: UDP glucuronosyltransferase 2 family%2C polypeptide B34 [Source:MGI Symbol;Acc:MGI:2140962] Location: 5:87037626-87054796 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Biological oxidations Aspirin ADME Paracetamol ADME
Azathioprine ADME Pathway Hierarchies & Genes Azathioprine ADME (2 genes) Drug ADME Azathioprine ADME 2 genes	Abcc4 Gene Information Basic Information Ensembl ID: ENSMUSG00000032849 Description: ATP-binding cassette%2C sub-family C member 4 [Source:MGI Symbol;Acc:MGI:2443111] Location: 14:118720104-118943631 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell epithelial cell Other: ABC-family proteins mediated transport Platelet activation, signaling and aggregation Azathioprine ADME Abcc5 Gene Information Basic Information Ensembl ID: ENSMUSG00000022822 Description: ATP-binding cassette%2C sub-family C member 5 [Source:MGI Symbol;Acc:MGI:1351644] Location: 16:20150053-20245144 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: embryonic cell Other: ABC-family proteins mediated transport Metabolism of carbohydrates and carbohydrate derivatives Azathioprine ADME
Binding and Uptake of Ligands by Scavenger Receptors Pathway Hierarchies & Genes Scavenging by Class A Receptors (1 genes) Vesicle-mediated transport Binding and Uptake of Ligands by Scavenger Receptors Scavenging by Class A Receptors 1 genes Scavenging of heme from plasma (1 genes) Vesicle-mediated transport Binding and Uptake of Ligands by Scavenger Receptors Scavenging of heme from plasma 1 genes	Igha Gene Information Basic Information Ensembl ID: ENSMUSG00000095079 Description: immunoglobulin heavy constant alpha [Source:MGI Symbol;Acc:MGI:96444] Location: 12:113218450-113223856 (-) Biotype: IG_C_gene Species: Mus musculus Annotations Cell Type Markers: Naive B cell plasma cell Other: Cell surface interactions at the vascular wall Binding and Uptake of Ligands by Scavenger Receptors Marco Gene Information Basic Information Ensembl ID: ENSMUSG00000026390 Description: macrophage receptor with collagenous structure [Source:MGI Symbol;Acc:MGI:1309998] Location: 1:120402267-120432753 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: antigen presenting cell Other: Binding and Uptake of Ligands by Scavenger Receptors
Biological oxidations Pathway Hierarchies & Genes CYP2E1 reactions (1 genes) Metabolism Biological oxidations Phase I - Functionalization of compounds Cytochrome P450 - arranged by substrate type Xenobiotics CYP2E1 reactions 1 genes Eicosanoids (1 genes) Metabolism Biological oxidations Phase I - Functionalization of compounds Cytochrome P450 - arranged by substrate type Eicosanoids 1 genes Vitamins (1 genes) Metabolism Biological oxidations Phase I - Functionalization of compounds Cytochrome P450 - arranged by substrate type Vitamins 1 genes COX reactions (1 genes) Metabolism Biological oxidations Phase I - Functionalization of compounds COX reactions 1 genes Cytosolic sulfonation of small molecules (1 genes) Metabolism Biological oxidations Phase II - Conjugation of compounds Cytosolic sulfonation of small molecules 1 genes Glucuronidation (1 genes) Metabolism Biological oxidations Phase II - Conjugation of compounds Glucuronidation 1 genes	Cyp26a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000024987 Description: cytochrome P450%2C family 26%2C subfamily a%2C polypeptide 1 [Source:MGI Symbol;Acc:MGI:1096359] Location: 19:37686246-37689984 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Biological oxidations Signaling by Nuclear Receptors Cyp2s1 Gene Information Basic Information Ensembl ID: ENSMUSG00000040703 Description: cytochrome P450%2C family 2%2C subfamily s%2C polypeptide 1 [Source:MGI Symbol;Acc:MGI:1921384] Location: 7:25501900-25516338 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Biological oxidations Ptgs1 Gene Information Basic Information Ensembl ID: ENSMUSG00000047250 Description: prostaglandin-endoperoxide synthase 1 [Source:MGI Symbol;Acc:MGI:97797] Location: 2:36120438-36142284 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell phagocyte fibroblast microglia tuft cell epithelial cell Other: Biological oxidations Metabolism of lipids Sult1b1 Gene Information Basic Information Ensembl ID: ENSMUSG00000029269 Description: sulfotransferase family 1B%2C member 1 [Source:MGI Symbol;Acc:MGI:2136282] Location: 5:87661198-87686054 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Biological oxidations Tbxas1 Gene Information Basic Information Ensembl ID: ENSMUSG00000029925 Description: thromboxane A synthase 1%2C platelet [Source:MGI Symbol;Acc:MGI:98497] Location: 6:38852338-39061519 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte Other: Biological oxidations Metabolism of lipids Ugt2b34 Gene Information Basic Information Ensembl ID: ENSMUSG00000029260 Description: UDP glucuronosyltransferase 2 family%2C polypeptide B34 [Source:MGI Symbol;Acc:MGI:2140962] Location: 5:87037626-87054796 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Biological oxidations Aspirin ADME Paracetamol ADME
Cardiac conduction Pathway Hierarchies & Genes Phase 2 - plateau phase (1 genes) Muscle contraction Cardiac conduction Phase 3 - rapid repolarisation Phase 2 - plateau phase 1 genes Ion homeostasis (2 genes) Muscle contraction Cardiac conduction Ion homeostasis 2 genes Physiological factors (1 genes) Muscle contraction Cardiac conduction Physiological factors 1 genes	Atp1a3 Gene Information Basic Information Ensembl ID: ENSMUSG00000040907 Description: ATPase%2C Na+/K+ transporting%2C alpha 3 polypeptide [Source:MGI Symbol;Acc:MGI:88107] Location: 7:24677592-24705383 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Cardiac conduction Ion channel transport Dmpk Gene Information Basic Information Ensembl ID: ENSMUSG00000030409 Description: dystrophia myotonica-protein kinase [Source:MGI Symbol;Acc:MGI:94906] Location: 7:18817774-18827746 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cardiac conduction Kcne3 Gene Information Basic Information Ensembl ID: ENSMUSG00000035165 Description: potassium voltage-gated channel%2C Isk-related subfamily%2C gene 3 [Source:MGI Symbol;Acc:MGI:1891124] Location: 7:99825709-99834076 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stem cell Other: Cardiac conduction Npr2 Gene Information Basic Information Ensembl ID: ENSMUSG00000028469 Description: natriuretic peptide receptor 2 [Source:MGI Symbol;Acc:MGI:97372] Location: 4:43631935-43651244 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Cardiac conduction
Cell Cycle Checkpoints Pathway Hierarchies & Genes Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (3 genes) Cell Cycle Cell Cycle Checkpoints Mitotic Spindle Checkpoint Amplification of signal from the kinetochores Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 3 genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (1 genes) Cell Cycle Cell Cycle Checkpoints G2/M Checkpoints G2/M DNA damage checkpoint Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 1 genes Activation of ATR in response to replication stress (1 genes) Cell Cycle Cell Cycle Checkpoints G2/M Checkpoints Activation of ATR in response to replication stress 1 genes G2/M DNA damage checkpoint (1 genes) Cell Cycle Cell Cycle Checkpoints G2/M Checkpoints G2/M DNA damage checkpoint 1 genes	Babam2 Gene Information Basic Information Ensembl ID: ENSMUSG00000052139 Description: BRISC and BRCA1 A complex member 2 [Source:MGI Symbol;Acc:MGI:1333875] Location: 5:31855028-32242306 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: DNA Double-Strand Break Repair Post-translational protein modification Cell Cycle Checkpoints Cdc45 Gene Information Basic Information Ensembl ID: ENSMUSG00000000028 Description: cell division cycle 45 [Source:MGI Symbol;Acc:MGI:1338073] Location: 16:18599197-18630737 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: DNA Replication Pre-Initiation Cell Cycle, Mitotic Cell Cycle Checkpoints Cdk1 Gene Information Basic Information Ensembl ID: ENSMUSG00000019942 Description: cyclin dependent kinase 1 [Source:MGI Symbol;Acc:MGI:88351] Location: 10:69170976-69188768 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: proliferative cell Other: Cytokine Signaling in Immune system Cilium Assembly MAPK family signaling cascades Nup85 Gene Information Basic Information Ensembl ID: ENSMUSG00000020739 Description: nucleoporin 85 [Source:MGI Symbol;Acc:MGI:3046173] Location: 11:115455260-115474811 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: bone cell Other: Metabolism of non-coding RNA Gene Silencing by RNA Cellular responses to stress Ppp2ca Gene Information Basic Information Ensembl ID: ENSMUSG00000020349 Description: protein phosphatase 2 (formerly 2A)%2C catalytic subunit%2C alpha isoform [Source:MGI Symbol;Acc:MGI:1321159] Location: 11:51989508-52018605 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Zw10 Gene Information Basic Information Ensembl ID: ENSMUSG00000032264 Description: zw10 kinetochore protein [Source:MGI Symbol;Acc:MGI:1349478] Location: 9:48966913-48990075 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Membrane Trafficking Cell Cycle, Mitotic Cell Cycle Checkpoints
Cell Cycle, Mitotic Pathway Hierarchies & Genes Loss of Nlp from mitotic centrosomes (1 genes) Cell Cycle Cell Cycle, Mitotic Regulation of mitotic cell cycle APC/C-mediated degradation of cell cycle proteins Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Cdc20:Phospho-APC/C mediated degradation of Cyclin A M Phase Mitotic Metaphase and Anaphase Mitotic Anaphase Nuclear Envelope (NE) Reassembly Initiation of Nuclear Envelope (NE) Reformation Mitotic G2-G2/M phases G2/M Transition Centrosome maturation Loss of proteins required for interphase microtubule organization from the centrosome Loss of Nlp from mitotic centrosomes 1 genes Cyclin A/B1/B2 associated events during G2/M transition (1 genes) Cell Cycle Cell Cycle, Mitotic Mitotic G1 phase and G1/S transition G1/S Transition E2F mediated regulation of DNA replication Inhibition of replication initiation of damaged DNA by RB1/E2F1 M Phase Mitotic Metaphase and Anaphase Mitotic Anaphase Nuclear Envelope (NE) Reassembly Initiation of Nuclear Envelope (NE) Reformation Mitotic G2-G2/M phases G2/M Transition Cyclin A/B1/B2 associated events during G2/M transition 1 genes Recruitment of NuMA to mitotic centrosomes (2 genes) Cell Cycle Cell Cycle, Mitotic Mitotic G2-G2/M phases G2/M Transition Centrosome maturation Loss of proteins required for interphase microtubule organization from the centrosome Loss of Nlp from mitotic centrosomes M Phase Mitotic Prometaphase Recruitment of NuMA to mitotic centrosomes 2 genes Postmitotic nuclear pore complex (NPC) reformation (1 genes) Cell Cycle Cell Cycle, Mitotic M Phase Mitotic Metaphase and Anaphase Mitotic Anaphase Nuclear Envelope (NE) Reassembly Postmitotic nuclear pore complex (NPC) reformation 1 genes Sealing of the nuclear envelope (NE) by ESCRT-III (1 genes) Cell Cycle Cell Cycle, Mitotic M Phase Mitotic Metaphase and Anaphase Mitotic Anaphase Nuclear Envelope (NE) Reassembly Sealing of the nuclear envelope (NE) by ESCRT-III 1 genes Separation of Sister Chromatids (1 genes) Cell Cycle Cell Cycle, Mitotic M Phase Mitotic Metaphase and Anaphase Mitotic Anaphase Separation of Sister Chromatids 1 genes Cyclin D associated events in G1 (3 genes) Cell Cycle Cell Cycle, Mitotic Mitotic G1 phase and G1/S transition G1 Phase Cyclin D associated events in G1 3 genes G1/S Transition (1 genes) Cell Cycle Cell Cycle, Mitotic Mitotic G1 phase and G1/S transition G1/S Transition 1 genes	Abl1 Gene Information Basic Information Ensembl ID: ENSMUSG00000026842 Description: c-abl oncogene 1%2C non-receptor tyrosine kinase [Source:MGI Symbol;Acc:MGI:87859] Location: 2:31578388-31694239 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Epigenetic regulation of gene expression Myogenesis Cdc45 Gene Information Basic Information Ensembl ID: ENSMUSG00000000028 Description: cell division cycle 45 [Source:MGI Symbol;Acc:MGI:1338073] Location: 16:18599197-18630737 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: DNA Replication Pre-Initiation Cell Cycle, Mitotic Cell Cycle Checkpoints Cdk1 Gene Information Basic Information Ensembl ID: ENSMUSG00000019942 Description: cyclin dependent kinase 1 [Source:MGI Symbol;Acc:MGI:88351] Location: 10:69170976-69188768 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: proliferative cell Other: Cytokine Signaling in Immune system Cilium Assembly MAPK family signaling cascades Cep57 Gene Information Basic Information Ensembl ID: ENSMUSG00000031922 Description: centrosomal protein 57 [Source:MGI Symbol;Acc:MGI:1915551] Location: 9:13719088-13738403 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cilium Assembly Cell Cycle, Mitotic Haus8 Gene Information Basic Information Ensembl ID: ENSMUSG00000035439 Description: 4HAUS augmin-like complex%2C subunit 8 [Source:MGI Symbol;Acc:MGI:1923728] Location: 8:71701205-71725578 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cilium Assembly Cell Cycle, Mitotic Jak2 Gene Information Basic Information Ensembl ID: ENSMUSG00000024789 Description: Janus kinase 2 [Source:MGI Symbol;Acc:MGI:96629] Location: 19:29229228-29290480 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell dendritic cell eosinophil Other: Cytokine Signaling in Immune system MAPK family signaling cascades Cell Cycle, Mitotic Lyn Gene Information Basic Information Ensembl ID: ENSMUSG00000042228 Description: LYN proto-oncogene%2C Src family tyrosine kinase [Source:MGI Symbol;Acc:MGI:96892] Location: 4:3678115-3813122 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Platelet Adhesion to exposed collagen Cytokine Signaling in Immune system Adaptive Immune System Nup85 Gene Information Basic Information Ensembl ID: ENSMUSG00000020739 Description: nucleoporin 85 [Source:MGI Symbol;Acc:MGI:3046173] Location: 11:115455260-115474811 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: bone cell Other: Metabolism of non-coding RNA Gene Silencing by RNA Cellular responses to stress Ppp2ca Gene Information Basic Information Ensembl ID: ENSMUSG00000020349 Description: protein phosphatase 2 (formerly 2A)%2C catalytic subunit%2C alpha isoform [Source:MGI Symbol;Acc:MGI:1321159] Location: 11:51989508-52018605 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Spast Gene Information Basic Information Ensembl ID: ENSMUSG00000024068 Description: spastin [Source:MGI Symbol;Acc:MGI:1858896] Location: 17:74645982-74698110 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cell Cycle, Mitotic Zw10 Gene Information Basic Information Ensembl ID: ENSMUSG00000032264 Description: zw10 kinetochore protein [Source:MGI Symbol;Acc:MGI:1349478] Location: 9:48966913-48990075 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Membrane Trafficking Cell Cycle, Mitotic Cell Cycle Checkpoints
Cell junction organization Pathway Hierarchies & Genes Degradation of CDH1 (6 genes) Cell-Cell communication Cell junction organization Cell-cell junction organization Adherens junctions interactions Regulation of Homotypic Cell-Cell Adhesion Regulation of Expression and Function of Type I Classical Cadherins Regulation of CDH1 Expression and Function Regulation of CDH1 Function Degradation of CDH1 6 genes Regulation of CDH1 Function (1 genes) Cell-Cell communication Cell junction organization Cell-cell junction organization Adherens junctions interactions Regulation of Homotypic Cell-Cell Adhesion Regulation of Expression and Function of Type I Classical Cadherins Regulation of CDH1 Expression and Function Regulation of CDH1 Function 1 genes Regulation of CDH11 gene transcription (2 genes) Cell-Cell communication Cell junction organization Cell-cell junction organization Adherens junctions interactions Regulation of Homotypic Cell-Cell Adhesion Regulation of Expression and Function of Type II Classical Cadherins Regulation of CDH11 Expression and Function Regulation of CDH11 gene transcription 2 genes Nectin/Necl trans heterodimerization (3 genes) Cell-Cell communication Cell junction organization Cell-cell junction organization Adherens junctions interactions Nectin/Necl trans heterodimerization 3 genes Adherens junctions interactions (6 genes) Cell-Cell communication Cell junction organization Cell-cell junction organization Adherens junctions interactions 6 genes Regulation of cytoskeletal remodeling and cell spreading by IPP complex components (1 genes) Cell-Cell communication Cell junction organization Cell-extracellular matrix interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 1 genes Tight junction interactions (2 genes) Cell-Cell communication Cell junction organization Cell-cell junction organization Tight junction interactions 2 genes Cell-extracellular matrix interactions (3 genes) Cell-Cell communication Cell junction organization Cell-extracellular matrix interactions 3 genes Type I hemidesmosome assembly (2 genes) Cell-Cell communication Cell junction organization Type I hemidesmosome assembly 2 genes	Acta2 Gene Information Basic Information Ensembl ID: ENSMUSG00000035783 Description: actin alpha 2%2C smooth muscle%2C aorta [Source:MGI Symbol;Acc:MGI:87909] Location: 19:34218490-34232990 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte stellate cell endothelial cell stem cell smooth muscle cell fibroblast mural cell mesangial cell progenitor cell muscle cell mesenchymal cell Other: Non-integrin membrane-ECM interactions Smooth Muscle Contraction Cell junction organization Cbll1 Gene Information Basic Information Ensembl ID: ENSMUSG00000020659 Description: Casitas B-lineage lymphoma-like 1 [Source:MGI Symbol;Acc:MGI:2144842] Location: 12:31534828-31549615 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Adaptive Immune System Cell junction organization Cdh10 Gene Information Basic Information Ensembl ID: ENSMUSG00000022321 Description: cadherin 10 [Source:MGI Symbol;Acc:MGI:107436] Location: 15:18819033-19014322 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: glial cell astrocyte Other: Cell junction organization Cdh13 Gene Information Basic Information Ensembl ID: ENSMUSG00000031841 Description: cadherin 13 [Source:MGI Symbol;Acc:MGI:99551] Location: 8:119010472-120051660 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell skeletal muscle cell fibroblast interneuron astrocyte Other: Cell junction organization Cdh2 Gene Information Basic Information Ensembl ID: ENSMUSG00000024304 Description: cadherin 2 [Source:MGI Symbol;Acc:MGI:88355] Location: 18:16721934-16942303 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte stellate cell glial cell skeletal muscle cell motor neuron osteoblast epithelial cell Other: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cell junction organization Myogenesis Cdh3 Gene Information Basic Information Ensembl ID: ENSMUSG00000061048 Description: cadherin 3 [Source:MGI Symbol;Acc:MGI:88356] Location: 8:107237523-107283929 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Cell junction organization Cdh4 Gene Information Basic Information Ensembl ID: ENSMUSG00000000305 Description: cadherin 4 [Source:MGI Symbol;Acc:MGI:99218] Location: 2:179084224-179541166 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: bergmann glial cell epithelial cell retina cell Other: Cell junction organization Myogenesis Cdh5 Gene Information Basic Information Ensembl ID: ENSMUSG00000031871 Description: cadherin 5 [Source:MGI Symbol;Acc:MGI:105057] Location: 8:104828257-104871143 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Cell junction organization Signaling by Receptor Tyrosine Kinases Ctnna1 Gene Information Basic Information Ensembl ID: ENSMUSG00000037815 Description: catenin alpha 1 [Source:MGI Symbol;Acc:MGI:88274] Location: 18:35251912-35387832 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Cell junction organization Myogenesis Signaling by Receptor Tyrosine Kinases Ctnnb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000006932 Description: catenin beta 1 [Source:MGI Symbol;Acc:MGI:88276] Location: 9:120758282-120789573 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stem cell epithelial cell Other: Apoptosis Innate Immune System Signaling by WNT Ctnnd1 Gene Information Basic Information Ensembl ID: ENSMUSG00000034101 Description: catenin delta 1 [Source:MGI Symbol;Acc:MGI:105100] Location: 2:84430415-84481109 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cell junction organization Signaling by Receptor Tyrosine Kinases F11r Gene Information Basic Information Ensembl ID: ENSMUSG00000038235 Description: F11 receptor [Source:MGI Symbol;Acc:MGI:1321398] Location: 1:171265103-171292171 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stem cell phagocyte epithelial cell Other: Cell surface interactions at the vascular wall Integrin cell surface interactions Cell junction organization Fblim1 Gene Information Basic Information Ensembl ID: ENSMUSG00000006219 Description: filamin binding LIM protein 1 [Source:MGI Symbol;Acc:MGI:1921452] Location: 4:141303373-141333407 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: smooth muscle cell Other: Cell junction organization Flna Gene Information Basic Information Ensembl ID: ENSMUSG00000031328 Description: filamin%2C alpha [Source:MGI Symbol;Acc:MGI:95556] Location: X:73267067-73293426 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte endothelial cell stem cell smooth muscle cell fibroblast monocyte epithelial cell neutrophil mural cell Other: Cell junction organization Platelet activation, signaling and aggregation Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Fyn Gene Information Basic Information Ensembl ID: ENSMUSG00000019843 Description: Fyn proto-oncogene [Source:MGI Symbol;Acc:MGI:95602] Location: 10:39244851-39441377 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cell surface interactions at the vascular wall Nephrin family interactions Cytokine Signaling in Immune system Ilf3 Gene Information Basic Information Ensembl ID: ENSMUSG00000032178 Description: interleukin enhancer binding factor 3 [Source:MGI Symbol;Acc:MGI:1339973] Location: 9:21279167-21316657 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Cell junction organization Itga6 Gene Information Basic Information Ensembl ID: ENSMUSG00000027111 Description: integrin alpha 6 [Source:MGI Symbol;Acc:MGI:96605] Location: 2:71575960-71688760 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell epithelial cell progenitor cell Other: Cell surface interactions at the vascular wall Integrin cell surface interactions Laminin interactions Itgb4 Gene Information Basic Information Ensembl ID: ENSMUSG00000020758 Description: integrin beta 4 [Source:MGI Symbol;Acc:MGI:96613] Location: 11:115865535-115899238 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell basal cell cardiomyocyte perineurial cell Other: Laminin interactions Non-integrin membrane-ECM interactions Cell junction organization Jup Gene Information Basic Information Ensembl ID: ENSMUSG00000001552 Description: junction plakoglobin [Source:MGI Symbol;Acc:MGI:96650] Location: 11:100259784-100288589 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stellate cell stem cell epithelial cell smooth muscle cell keratinocyte basal cell Other: Innate Immune System Cell junction organization Keratinization Lims1 Gene Information Basic Information Ensembl ID: ENSMUSG00000019920 Description: LIM and senescent cell antigen-like domains 1 [Source:MGI Symbol;Acc:MGI:1195263] Location: 10:58159288-58260513 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte stromal cell megakaryocyte Other: Cell junction organization Lims2 Gene Information Basic Information Ensembl ID: ENSMUSG00000024395 Description: LIM and senescent cell antigen like domains 2 [Source:MGI Symbol;Acc:MGI:2385067] Location: 18:32055343-32091672 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell smooth muscle cell Other: Cell junction organization Nectin1 Gene Information Basic Information Ensembl ID: ENSMUSG00000032012 Description: nectin cell adhesion molecule 1 [Source:MGI Symbol;Acc:MGI:1926483] Location: 9:43655281-43743955 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cell junction organization Nectin3 Gene Information Basic Information Ensembl ID: ENSMUSG00000022656 Description: nectin cell adhesion molecule 3 [Source:MGI Symbol;Acc:MGI:1930171] Location: 16:46208069-46318888 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pneumocyte Other: Cell junction organization Pard3 Gene Information Basic Information Ensembl ID: ENSMUSG00000025812 Description: par-3 family cell polarity regulator [Source:MGI Symbol;Acc:MGI:2135608] Location: 8:127790643-128338767 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell motor neuron Other: Cell junction organization Signaling by TGFB family members Pvr Gene Information Basic Information Ensembl ID: ENSMUSG00000040511 Description: poliovirus receptor [Source:MGI Symbol;Acc:MGI:107741] Location: 7:19637503-19655085 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Adaptive Immune System Cell junction organization Zeb2 Gene Information Basic Information Ensembl ID: ENSMUSG00000026872 Description: zinc finger E-box binding homeobox 2 [Source:MGI Symbol;Acc:MGI:1344407] Location: 2:44873644-45007407 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell stromal cell phagocyte monocyte fibroblast glial cell motor neuron antigen presenting cell Other: Cell junction organization
Cell surface interactions at the vascular wall Pathway Hierarchies & Genes Tie2 Signaling (39 genes) Hemostasis Cell surface interactions at the vascular wall 21 genes PECAM1 interactions 17 genes Tie2 Signaling 1 genes	Angpt1 Gene Information Basic Information Ensembl ID: ENSMUSG00000022309 Description: angiopoietin 1 [Source:MGI Symbol;Acc:MGI:108448] Location: 15:42288119-42540373 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast preadipocyte cardiomyocyte astrocyte Other: Cell surface interactions at the vascular wall MAPK family signaling cascades Angpt2 Gene Information Basic Information Ensembl ID: ENSMUSG00000031465 Description: angiopoietin 2 [Source:MGI Symbol;Acc:MGI:1202890] Location: 8:18740279-18791578 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: retina cell endothelial cell dendritic cell Other: Cell surface interactions at the vascular wall Angpt4 Gene Information Basic Information Ensembl ID: ENSMUSG00000027460 Description: angiopoietin 4 [Source:MGI Symbol;Acc:MGI:1336887] Location: 2:151753130-151787257 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cell surface interactions at the vascular wall Cav1 Gene Information Basic Information Ensembl ID: ENSMUSG00000007655 Description: caveolin 1%2C caveolae protein [Source:MGI Symbol;Acc:MGI:102709] Location: 6:17306334-17341451 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by WNT Metabolism of nitric oxide: NOS3 activation and regulation Cell surface interactions at the vascular wall Cd44 Gene Information Basic Information Ensembl ID: ENSMUSG00000005087 Description: CD44 antigen [Source:MGI Symbol;Acc:MGI:88338] Location: 2:102641486-102732010 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell phagocyte monocyte granulocyte neutrophil macrophage progenitor cell Other: Cell surface interactions at the vascular wall Integrin cell surface interactions Innate Immune System Col1a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000001506 Description: collagen%2C type I%2C alpha 1 [Source:MGI Symbol;Acc:MGI:88467] Location: 11:94827050-94843868 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stellate cell pericyte stromal cell stem cell valve interstitial cell mesenchymal cell endothelial cell Other: ECM proteoglycans Platelet Adhesion to exposed collagen Adaptive Immune System Col1a2 Gene Information Basic Information Ensembl ID: ENSMUSG00000029661 Description: collagen%2C type I%2C alpha 2 [Source:MGI Symbol;Acc:MGI:88468] Location: 6:4504814-4541544 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stellate cell pericyte stem cell stromal cell epithelial cell vascular cell meningeal cell Other: Adaptive Immune System Degradation of the extracellular matrix Collagen formation Cxadr Gene Information Basic Information Ensembl ID: ENSMUSG00000022865 Description: coxsackie virus and adenovirus receptor [Source:MGI Symbol;Acc:MGI:1201679] Location: 16:78098377-78156662 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell fibroblast pneumocyte Other: Adaptive Immune System Cell surface interactions at the vascular wall Epcam Gene Information Basic Information Ensembl ID: ENSMUSG00000045394 Description: epithelial cell adhesion molecule [Source:MGI Symbol;Acc:MGI:106653] Location: 17:87943407-87958557 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell stem cell enteroendocrine cell Other: Cell surface interactions at the vascular wall Esam Gene Information Basic Information Ensembl ID: ENSMUSG00000001946 Description: endothelial cell-specific adhesion molecule [Source:MGI Symbol;Acc:MGI:1916774] Location: 9:37439374-37449615 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell pericyte Other: Cell surface interactions at the vascular wall F11r Gene Information Basic Information Ensembl ID: ENSMUSG00000038235 Description: F11 receptor [Source:MGI Symbol;Acc:MGI:1321398] Location: 1:171265103-171292171 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stem cell phagocyte epithelial cell Other: Cell surface interactions at the vascular wall Integrin cell surface interactions Cell junction organization Fyn Gene Information Basic Information Ensembl ID: ENSMUSG00000019843 Description: Fyn proto-oncogene [Source:MGI Symbol;Acc:MGI:95602] Location: 10:39244851-39441377 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cell surface interactions at the vascular wall Nephrin family interactions Cytokine Signaling in Immune system Gpc1 Gene Information Basic Information Ensembl ID: ENSMUSG00000034220 Description: glypican 1 [Source:MGI Symbol;Acc:MGI:1194891] Location: 1:92759367-92788501 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: glial cell podocyte Other: Metabolism of vitamins and cofactors Cell surface interactions at the vascular wall Visual phototransduction Igha Gene Information Basic Information Ensembl ID: ENSMUSG00000095079 Description: immunoglobulin heavy constant alpha [Source:MGI Symbol;Acc:MGI:96444] Location: 12:113218450-113223856 (-) Biotype: IG_C_gene Species: Mus musculus Annotations Cell Type Markers: Naive B cell plasma cell Other: Cell surface interactions at the vascular wall Binding and Uptake of Ligands by Scavenger Receptors Itga3 Gene Information Basic Information Ensembl ID: ENSMUSG00000001507 Description: integrin alpha 3 [Source:MGI Symbol;Acc:MGI:96602] Location: 11:94935300-94967627 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Cell surface interactions at the vascular wall Integrin cell surface interactions Laminin interactions Itga4 Gene Information Basic Information Ensembl ID: ENSMUSG00000027009 Description: integrin alpha 4 [Source:MGI Symbol;Acc:MGI:96603] Location: 2:79085770-79163467 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell Regulatory T cell CD8+ T cell monocyte T cell Specialized T cell Other: Adaptive Immune System Cell surface interactions at the vascular wall Integrin cell surface interactions Itga5 Gene Information Basic Information Ensembl ID: ENSMUSG00000000555 Description: integrin alpha 5 (fibronectin receptor alpha) [Source:MGI Symbol;Acc:MGI:96604] Location: 15:103252713-103275190 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Elastic fibre formation Fibronectin matrix formation Cell surface interactions at the vascular wall Itga6 Gene Information Basic Information Ensembl ID: ENSMUSG00000027111 Description: integrin alpha 6 [Source:MGI Symbol;Acc:MGI:96605] Location: 2:71575960-71688760 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell epithelial cell progenitor cell Other: Cell surface interactions at the vascular wall Integrin cell surface interactions Laminin interactions Itgal Gene Information Basic Information Ensembl ID: ENSMUSG00000030830 Description: integrin alpha L [Source:MGI Symbol;Acc:MGI:96606] Location: 7:126895432-126934310 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell CD4+ T cell CD8+ T cell monocyte Specialized T cell Other: Adaptive Immune System Innate Immune System Cell surface interactions at the vascular wall Itgam Gene Information Basic Information Ensembl ID: ENSMUSG00000030786 Description: integrin alpha M [Source:MGI Symbol;Acc:MGI:96607] Location: 7:127661812-127717663 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell phagocyte macrophage monocyte myeloid cell dendritic cell microglia myeloid derived suppressor cell immune cell Other: Innate Immune System Cell surface interactions at the vascular wall Integrin cell surface interactions Itgav Gene Information Basic Information Ensembl ID: ENSMUSG00000027087 Description: integrin alpha V [Source:MGI Symbol;Acc:MGI:96608] Location: 2:83554741-83637260 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell bone cell Other: ECM proteoglycans Non-integrin membrane-ECM interactions Adaptive Immune System Itgax Gene Information Basic Information Ensembl ID: ENSMUSG00000030789 Description: integrin alpha X [Source:MGI Symbol;Acc:MGI:96609] Location: 7:127728719-127749829 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell phagocyte macrophage dendritic cell Other: Innate Immune System Cell surface interactions at the vascular wall Integrin cell surface interactions Itgb2 Gene Information Basic Information Ensembl ID: ENSMUSG00000000290 Description: integrin beta 2 [Source:MGI Symbol;Acc:MGI:96611] Location: 10:77366086-77401542 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell monocyte neutrophil Other: Adaptive Immune System Innate Immune System Cell surface interactions at the vascular wall Itgb3 Gene Information Basic Information Ensembl ID: ENSMUSG00000020689 Description: integrin beta 3 [Source:MGI Symbol;Acc:MGI:96612] Location: 11:104498826-104561302 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell stromal cell bone cell megakaryocyte Other: Elastic fibre formation Cell surface interactions at the vascular wall Integrin cell surface interactions Jam3 Gene Information Basic Information Ensembl ID: ENSMUSG00000031990 Description: junction adhesion molecule 3 [Source:MGI Symbol;Acc:MGI:1933825] Location: 9:27008680-27066717 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell glial cell muscle cell schwann cell dendritic cell Other: Cell surface interactions at the vascular wall Integrin cell surface interactions Lyn Gene Information Basic Information Ensembl ID: ENSMUSG00000042228 Description: LYN proto-oncogene%2C Src family tyrosine kinase [Source:MGI Symbol;Acc:MGI:96892] Location: 4:3678115-3813122 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Platelet Adhesion to exposed collagen Cytokine Signaling in Immune system Adaptive Immune System Pecam1 Gene Information Basic Information Ensembl ID: ENSMUSG00000020717 Description: platelet/endothelial cell adhesion molecule 1 [Source:MGI Symbol;Acc:MGI:97537] Location: 11:106545043-106641454 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell epithelial cell Other: Innate Immune System Cell surface interactions at the vascular wall Integrin cell surface interactions Plcg1 Gene Information Basic Information Ensembl ID: ENSMUSG00000016933 Description: phospholipase C%2C gamma 1 [Source:MGI Symbol;Acc:MGI:97615] Location: 2:160573220-160617680 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Inositol phosphate metabolism Ptpn11 Gene Information Basic Information Ensembl ID: ENSMUSG00000043733 Description: protein tyrosine phosphatase%2C non-receptor type 11 [Source:MGI Symbol;Acc:MGI:99511] Location: 5:121268596-121329460 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Nervous system development Cytokine Signaling in Immune system Adaptive Immune System Ptpn6 Gene Information Basic Information Ensembl ID: ENSMUSG00000004266 Description: protein tyrosine phosphatase%2C non-receptor type 6 [Source:MGI Symbol;Acc:MGI:96055] Location: 6:124697670-124715677 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell Naive B cell tuft cell monocyte dendritic cell macrophage Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Sdc2 Gene Information Basic Information Ensembl ID: ENSMUSG00000022261 Description: syndecan 2 [Source:MGI Symbol;Acc:MGI:1349165] Location: 15:32920869-33035081 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte osteoblast mural cell Other: Metabolism of vitamins and cofactors Cell surface interactions at the vascular wall Visual phototransduction Selp Gene Information Basic Information Ensembl ID: ENSMUSG00000026580 Description: selectin%2C platelet [Source:MGI Symbol;Acc:MGI:98280] Location: 1:163942833-163977595 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Cell surface interactions at the vascular wall Platelet activation, signaling and aggregation Shc1 Gene Information Basic Information Ensembl ID: ENSMUSG00000042626 Description: src homology 2 domain-containing transforming protein C1 [Source:MGI Symbol;Acc:MGI:98296] Location: 3:89325750-89337334 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Innate Immune System Cell surface interactions at the vascular wall Slc7a11 Gene Information Basic Information Ensembl ID: ENSMUSG00000027737 Description: solute carrier family 7 (cationic amino acid transporter%2C y+ system)%2C member 11 [Source:MGI Symbol;Acc:MGI:1347355] Location: 3:49846975-50398063 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell fibroblast granulocyte monocyte retinal pigment epithelial cell Other: Cell surface interactions at the vascular wall SLC-mediated transmembrane transport Sos1 Gene Information Basic Information Ensembl ID: ENSMUSG00000024241 Description: SOS Ras/Rac guanine nucleotide exchange factor 1 [Source:MGI Symbol;Acc:MGI:98354] Location: 17:80701180-80787882 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Tek Gene Information Basic Information Ensembl ID: ENSMUSG00000006386 Description: TEK receptor tyrosine kinase [Source:MGI Symbol;Acc:MGI:98664] Location: 4:94627526-94763213 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Cell surface interactions at the vascular wall MAPK family signaling cascades Tgfb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000002603 Description: transforming growth factor%2C beta 1 [Source:MGI Symbol;Acc:MGI:98725] Location: 7:25386427-25404502 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell hematopoietic stem cell phagocyte monocyte leukocyte megakaryocyte Other: Cell surface interactions at the vascular wall Non-integrin membrane-ECM interactions Elastic fibre formation Tnfrsf10b Gene Information Basic Information Ensembl ID: ENSMUSG00000022074 Description: tumor necrosis factor receptor superfamily%2C member 10b [Source:MGI Symbol;Acc:MGI:1341090] Location: 14:70004921-70021860 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Apoptosis Cell surface interactions at the vascular wall Regulated Necrosis Trem1 Gene Information Basic Information Ensembl ID: ENSMUSG00000042265 Description: triggering receptor expressed on myeloid cells 1 [Source:MGI Symbol;Acc:MGI:1930005] Location: 17:48539796-48553952 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell granulocyte monocyte Other: Adaptive Immune System Innate Immune System Cell surface interactions at the vascular wall
Cellular responses to mechanical stimuli Pathway Hierarchies & Genes High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (6 genes) Cellular responses to stimuli Cellular responses to mechanical stimuli Response of endothelial cells to shear stress High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells 6 genes Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (8 genes) Cellular responses to stimuli Cellular responses to mechanical stimuli Response of endothelial cells to shear stress Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells 8 genes	Abl1 Gene Information Basic Information Ensembl ID: ENSMUSG00000026842 Description: c-abl oncogene 1%2C non-receptor tyrosine kinase [Source:MGI Symbol;Acc:MGI:87859] Location: 2:31578388-31694239 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Epigenetic regulation of gene expression Myogenesis Anxa2 Gene Information Basic Information Ensembl ID: ENSMUSG00000032231 Description: annexin A2 [Source:MGI Symbol;Acc:MGI:88246] Location: 9:69360902-69399077 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell endothelial cell natural killer cell stem cell epithelial cell monocyte Other: Innate Immune System Dissolution of Fibrin Clot Cellular responses to mechanical stimuli Calcrl Gene Information Basic Information Ensembl ID: ENSMUSG00000059588 Description: calcitonin receptor-like [Source:MGI Symbol;Acc:MGI:1926944] Location: 2:84160970-84255755 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell endocardial cell Other: Signaling by GPCR Cellular responses to mechanical stimuli Gna11 Gene Information Basic Information Ensembl ID: ENSMUSG00000034781 Description: guanine nucleotide binding protein%2C alpha 11 [Source:MGI Symbol;Acc:MGI:95766] Location: 10:81364558-81381024 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell endothelial cell enterocyte Other: Integration of energy metabolism Signaling by GPCR Protein folding Gnaq Gene Information Basic Information Ensembl ID: ENSMUSG00000024639 Description: guanine nucleotide binding protein%2C alpha q polypeptide [Source:MGI Symbol;Acc:MGI:95776] Location: 19:16110195-16364827 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: antigen presenting cell Other: Integration of energy metabolism Signaling by GPCR Protein folding Gngt2 Gene Information Basic Information Ensembl ID: ENSMUSG00000038811 Description: guanine nucleotide binding protein (G protein)%2C gamma transducing activity polypeptide 2 [Source:MGI Symbol;Acc:MGI:893584] Location: 11:95728042-95736560 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell dendritic cell phagocyte monocyte myeloid cell plasma cell macrophage photoreceptor cell Other: Platelet homeostasis Transmission across Chemical Synapses Potassium Channels Itga5 Gene Information Basic Information Ensembl ID: ENSMUSG00000000555 Description: integrin alpha 5 (fibronectin receptor alpha) [Source:MGI Symbol;Acc:MGI:96604] Location: 15:103252713-103275190 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Elastic fibre formation Fibronectin matrix formation Cell surface interactions at the vascular wall Itgav Gene Information Basic Information Ensembl ID: ENSMUSG00000027087 Description: integrin alpha V [Source:MGI Symbol;Acc:MGI:96608] Location: 2:83554741-83637260 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell bone cell Other: ECM proteoglycans Non-integrin membrane-ECM interactions Adaptive Immune System Itgb3 Gene Information Basic Information Ensembl ID: ENSMUSG00000020689 Description: integrin beta 3 [Source:MGI Symbol;Acc:MGI:96612] Location: 11:104498826-104561302 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell stromal cell bone cell megakaryocyte Other: Elastic fibre formation Cell surface interactions at the vascular wall Integrin cell surface interactions P2ry2 Gene Information Basic Information Ensembl ID: ENSMUSG00000032860 Description: purinergic receptor P2Y%2C G-protein coupled 2 [Source:MGI Symbol;Acc:MGI:105107] Location: 7:100645775-100662073 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by GPCR Surfactant metabolism Cellular responses to mechanical stimuli Pde4d Gene Information Basic Information Ensembl ID: ENSMUSG00000021699 Description: phosphodiesterase 4D%2C cAMP specific [Source:MGI Symbol;Acc:MGI:99555] Location: 13:108586482-110089995 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell skeletal muscle cell neuron pneumocyte stromal cell Other: Signaling by GPCR Cellular responses to mechanical stimuli Ppp2ca Gene Information Basic Information Ensembl ID: ENSMUSG00000020349 Description: protein phosphatase 2 (formerly 2A)%2C catalytic subunit%2C alpha isoform [Source:MGI Symbol;Acc:MGI:1321159] Location: 11:51989508-52018605 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Prr5 Gene Information Basic Information Ensembl ID: ENSMUSG00000036106 Description: proline rich 5 (renal) [Source:MGI Symbol;Acc:MGI:1924714] Location: 15:84553821-84587874 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: plasma cell Other: Adaptive Immune System RNA Polymerase II Transcription Intracellular signaling by second messengers Rela Gene Information Basic Information Ensembl ID: ENSMUSG00000024927 Description: v-rel reticuloendotheliosis viral oncogene homolog A (avian) [Source:MGI Symbol;Acc:MGI:103290] Location: 19:5687511-5698158 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System
Cellular responses to stress Pathway Hierarchies & Genes GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (2 genes) Cellular responses to stimuli Cellular responses to stress Cellular response to heat stress Regulation of HSF1-mediated heat shock response 1 genes Cellular response to chemical stress KEAP1-NFE2L2 pathway Nuclear events mediated by NFE2L2 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 1 genes HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (1 genes) Cellular responses to stimuli Cellular responses to stress Cellular response to heat stress HSF1-dependent transactivation Attenuation phase HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 1 genes Amino acids regulate mTORC1 (1 genes) Cellular responses to stimuli Cellular responses to stress Cellular response to starvation Amino acids regulate mTORC1 1 genes Cytoprotection by HMOX1 (2 genes) Cellular responses to stimuli Cellular responses to stress Cellular response to chemical stress Cytoprotection by HMOX1 2 genes Detoxification of Reactive Oxygen Species (4 genes) Cellular responses to stimuli Cellular responses to stress Cellular response to chemical stress Detoxification of Reactive Oxygen Species 4 genes Oncogene Induced Senescence (1 genes) Cellular responses to stimuli Cellular responses to stress Cellular Senescence Oncogene Induced Senescence 1 genes Oxidative Stress Induced Senescence (2 genes) Cellular responses to stimuli Cellular responses to stress Cellular Senescence Oxidative Stress Induced Senescence 2 genes Heme signaling (1 genes) Cellular responses to stimuli Cellular responses to stress Heme signaling 1 genes Mitochondrial unfolded protein response (UPRmt) (1 genes) Cellular responses to stimuli Cellular responses to stress Mitochondrial unfolded protein response (UPRmt) 1 genes	Abcc1 Gene Information Basic Information Ensembl ID: ENSMUSG00000023088 Description: ATP-binding cassette%2C sub-family C member 1 [Source:MGI Symbol;Acc:MGI:102676] Location: 16:14179422-14293601 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: ABC-family proteins mediated transport Metabolism of porphyrins Metabolism of vitamins and cofactors Cybb Gene Information Basic Information Ensembl ID: ENSMUSG00000015340 Description: cytochrome b-245%2C beta polypeptide [Source:MGI Symbol;Acc:MGI:88574] Location: X:9301491-9354010 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: monocyte Other: Adaptive Immune System Innate Immune System Cellular responses to stress Dnajb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000005483 Description: DnaJ heat shock protein family (Hsp40) member B1 [Source:MGI Symbol;Acc:MGI:1931874] Location: 8:84334822-84339282 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stem cell basal cell Other: Cellular responses to stress MAPK family signaling cascades Esr1 Gene Information Basic Information Ensembl ID: ENSMUSG00000019768 Description: estrogen receptor 1 (alpha) [Source:MGI Symbol;Acc:MGI:1352467] Location: 10:4561593-4955614 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by Receptor Tyrosine Kinases Cellular responses to stress Post-translational protein modification Ets1 Gene Information Basic Information Ensembl ID: ENSMUSG00000032035 Description: E26 avian leukemia oncogene 1%2C 5' domain [Source:MGI Symbol;Acc:MGI:95455] Location: 9:32547517-32669116 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell natural killer cell developing T cell leukocyte T cell lymphocyte Other: Cellular responses to stress Gsk3b Gene Information Basic Information Ensembl ID: ENSMUSG00000022812 Description: glycogen synthase kinase 3 beta [Source:MGI Symbol;Acc:MGI:1861437] Location: 16:37909363-38066446 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by WNT Epigenetic regulation of gene expression Cellular responses to stress Gsr Gene Information Basic Information Ensembl ID: ENSMUSG00000031584 Description: glutathione reductase [Source:MGI Symbol;Acc:MGI:95804] Location: 8:34142551-34188191 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: myeloid cell neutrophil myeloid derived suppressor cell immune cell Other: Metabolism of nucleotides Cellular responses to stress RNA Polymerase II Transcription Map2k6 Gene Information Basic Information Ensembl ID: ENSMUSG00000020623 Description: mitogen-activated protein kinase kinase 6 [Source:MGI Symbol;Acc:MGI:1346870] Location: 11:110289948-110416348 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: bergmann glial cell skeletal muscle cell Other: Cytokine Signaling in Immune system Innate Immune System Cellular responses to stress Mapk8 Gene Information Basic Information Ensembl ID: ENSMUSG00000021936 Description: mitogen-activated protein kinase 8 [Source:MGI Symbol;Acc:MGI:1346861] Location: 14:33099855-33169115 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System Med1 Gene Information Basic Information Ensembl ID: ENSMUSG00000018160 Description: mediator complex subunit 1 [Source:MGI Symbol;Acc:MGI:1100846] Location: 11:98042980-98084119 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cellular responses to stress Metabolism of lipids RNA Polymerase II Transcription Ncf1 Gene Information Basic Information Ensembl ID: ENSMUSG00000015950 Description: neutrophil cytosolic factor 1 [Source:MGI Symbol;Acc:MGI:97283] Location: 5:134248907-134258479 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell hematopoietic stem cell phagocyte granulocyte Other: Adaptive Immune System Innate Immune System Cellular responses to stress Ncf4 Gene Information Basic Information Ensembl ID: ENSMUSG00000071715 Description: neutrophil cytosolic factor 4 [Source:MGI Symbol;Acc:MGI:109186] Location: 15:78129001-78146780 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell dendritic cell erythrocyte granulocyte monocyte Other: Adaptive Immune System Innate Immune System Cellular responses to stress Nup85 Gene Information Basic Information Ensembl ID: ENSMUSG00000020739 Description: nucleoporin 85 [Source:MGI Symbol;Acc:MGI:3046173] Location: 11:115455260-115474811 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: bone cell Other: Metabolism of non-coding RNA Gene Silencing by RNA Cellular responses to stress Rragd Gene Information Basic Information Ensembl ID: ENSMUSG00000028278 Description: Ras-related GTP binding D [Source:MGI Symbol;Acc:MGI:1098604] Location: 4:32983037-33022180 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Macroautophagy MTOR signalling Cellular responses to stress Tlr4 Gene Information Basic Information Ensembl ID: ENSMUSG00000039005 Description: toll-like receptor 4 [Source:MGI Symbol;Acc:MGI:96824] Location: 4:66745821-66848521 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte Other: Apoptosis Innate Immune System Cellular responses to stress
Chromatin modifying enzymes Pathway Hierarchies & Genes PKMTs methylate histone lysines (1 genes) Chromatin organization Chromatin modifying enzymes PKMTs methylate histone lysines 1 genes	Rela Gene Information Basic Information Ensembl ID: ENSMUSG00000024927 Description: v-rel reticuloendotheliosis viral oncogene homolog A (avian) [Source:MGI Symbol;Acc:MGI:103290] Location: 19:5687511-5698158 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System
Cilium Assembly Pathway Hierarchies & Genes BBSome-mediated cargo-targeting to cilium (2 genes) Organelle biogenesis and maintenance Cilium Assembly Cargo trafficking to the periciliary membrane BBSome-mediated cargo-targeting to cilium 2 genes VxPx cargo-targeting to cilium (4 genes) Organelle biogenesis and maintenance Cilium Assembly Cargo trafficking to the periciliary membrane 3 genes VxPx cargo-targeting to cilium 1 genes Anchoring of the basal body to the plasma membrane (2 genes) Organelle biogenesis and maintenance Cilium Assembly Anchoring of the basal body to the plasma membrane 2 genes	Bbs1 Gene Information Basic Information Ensembl ID: ENSMUSG00000006464 Description: Bardet-Biedl syndrome 1 [Source:MGI Symbol;Acc:MGI:1277215] Location: 19:4936906-4956656 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cilium Assembly Cdk1 Gene Information Basic Information Ensembl ID: ENSMUSG00000019942 Description: cyclin dependent kinase 1 [Source:MGI Symbol;Acc:MGI:88351] Location: 10:69170976-69188768 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: proliferative cell Other: Cytokine Signaling in Immune system Cilium Assembly MAPK family signaling cascades Cep57 Gene Information Basic Information Ensembl ID: ENSMUSG00000031922 Description: centrosomal protein 57 [Source:MGI Symbol;Acc:MGI:1915551] Location: 9:13719088-13738403 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cilium Assembly Cell Cycle, Mitotic Fbf1 Gene Information Basic Information Ensembl ID: ENSMUSG00000020776 Description: Fas binding factor 1 [Source:MGI Symbol;Acc:MGI:1922033] Location: 11:116033111-116058992 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cilium Assembly Haus8 Gene Information Basic Information Ensembl ID: ENSMUSG00000035439 Description: 4HAUS augmin-like complex%2C subunit 8 [Source:MGI Symbol;Acc:MGI:1923728] Location: 8:71701205-71725578 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cilium Assembly Cell Cycle, Mitotic Pkd1 Gene Information Basic Information Ensembl ID: ENSMUSG00000032855 Description: polycystin 1%2C transient receptor potential channel interacting [Source:MGI Symbol;Acc:MGI:97603] Location: 17:24768808-24815482 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cilium Assembly Rpgrip1l Gene Information Basic Information Ensembl ID: ENSMUSG00000033282 Description: Rpgrip1-like [Source:MGI Symbol;Acc:MGI:1920563] Location: 8:91943658-92039890 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cilium Assembly Signaling by Hedgehog Smo Gene Information Basic Information Ensembl ID: ENSMUSG00000001761 Description: smoothened%2C frizzled class receptor [Source:MGI Symbol;Acc:MGI:108075] Location: 6:29735502-29761364 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by Hedgehog Cilium Assembly
Class I peroxisomal membrane protein import Pathway Hierarchies & Genes Class I peroxisomal membrane protein import (2 genes) Protein localization Class I peroxisomal membrane protein import 2 genes	Abcd1 Gene Information Basic Information Ensembl ID: ENSMUSG00000031378 Description: ATP-binding cassette%2C sub-family D member 1 [Source:MGI Symbol;Acc:MGI:1349215] Location: X:72760203-72782140 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: ABC-family proteins mediated transport Metabolism of lipids Class I peroxisomal membrane protein import Abcd2 Gene Information Basic Information Ensembl ID: ENSMUSG00000055782 Description: ATP-binding cassette%2C sub-family D member 2 [Source:MGI Symbol;Acc:MGI:1349467] Location: 15:91030074-91076002 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: adipocyte Other: ABC-family proteins mediated transport Class I peroxisomal membrane protein import
Collagen formation Pathway Hierarchies & Genes Crosslinking of collagen fibrils (9 genes) Extracellular matrix organization Collagen formation Collagen biosynthesis and modifying enzymes Collagen chain trimerization 1 genes Assembly of collagen fibrils and other multimeric structures 6 genes Crosslinking of collagen fibrils 2 genes Assembly of collagen fibrils and other multimeric structures (1 genes) Extracellular matrix organization Collagen formation Assembly of collagen fibrils and other multimeric structures 1 genes Collagen biosynthesis and modifying enzymes (3 genes) Extracellular matrix organization Collagen formation Collagen biosynthesis and modifying enzymes 3 genes	Adamts2 Gene Information Basic Information Ensembl ID: ENSMUSG00000036545 Description: ADAM metallopeptidase with thrombospondin type 1 motif 2 [Source:MGI Symbol;Acc:MGI:1347356] Location: 11:50492911-50698400 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast epithelial cell osteoblast Other: Collagen formation Post-translational protein modification Col12a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000032332 Description: collagen%2C type XII%2C alpha 1 [Source:MGI Symbol;Acc:MGI:88448] Location: 9:79506273-79626113 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast endothelial cell Other: Degradation of the extracellular matrix Collagen formation Col13a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000058806 Description: collagen%2C type XIII%2C alpha 1 [Source:MGI Symbol;Acc:MGI:1277201] Location: 10:61674015-61814887 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast endothelial cell osteoblast Other: Degradation of the extracellular matrix Collagen formation Integrin cell surface interactions Col14a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000022371 Description: collagen%2C type XIV%2C alpha 1 [Source:MGI Symbol;Acc:MGI:1341272] Location: 15:55171146-55384199 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stellate cell glial cell epithelial cell Other: Collagen formation Col15a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000028339 Description: collagen%2C type XV%2C alpha 1 [Source:MGI Symbol;Acc:MGI:88449] Location: 4:47208161-47313167 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast endothelial cell pericyte Other: Degradation of the extracellular matrix Collagen formation Col1a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000001506 Description: collagen%2C type I%2C alpha 1 [Source:MGI Symbol;Acc:MGI:88467] Location: 11:94827050-94843868 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stellate cell pericyte stromal cell stem cell valve interstitial cell mesenchymal cell endothelial cell Other: ECM proteoglycans Platelet Adhesion to exposed collagen Adaptive Immune System Col1a2 Gene Information Basic Information Ensembl ID: ENSMUSG00000029661 Description: collagen%2C type I%2C alpha 2 [Source:MGI Symbol;Acc:MGI:88468] Location: 6:4504814-4541544 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stellate cell pericyte stem cell stromal cell epithelial cell vascular cell meningeal cell Other: Adaptive Immune System Degradation of the extracellular matrix Collagen formation Col5a2 Gene Information Basic Information Ensembl ID: ENSMUSG00000026042 Description: collagen%2C type V%2C alpha 2 [Source:MGI Symbol;Acc:MGI:88458] Location: 1:45413481-45542442 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast pericyte stellate cell stromal cell mesenchymal cell Other: Degradation of the extracellular matrix Collagen formation Fibronectin matrix formation Col6a2 Gene Information Basic Information Ensembl ID: ENSMUSG00000020241 Description: collagen%2C type VI%2C alpha 2 [Source:MGI Symbol;Acc:MGI:88460] Location: 10:76431596-76459464 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stellate cell pericyte pneumocyte stromal cell epithelial cell Other: Degradation of the extracellular matrix Collagen formation Integrin cell surface interactions Col6a3 Gene Information Basic Information Ensembl ID: ENSMUSG00000048126 Description: collagen%2C type VI%2C alpha 3 [Source:MGI Symbol;Acc:MGI:88461] Location: 1:90693645-90771693 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast pericyte stellate cell stromal cell Other: Degradation of the extracellular matrix Collagen formation Integrin cell surface interactions Colgalt1 Gene Information Basic Information Ensembl ID: ENSMUSG00000034807 Description: collagen beta(1-O)galactosyltransferase 1 [Source:MGI Symbol;Acc:MGI:1924348] Location: 8:72063642-72077555 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: macrophage kupffer cell Other: Collagen formation Mmp13 Gene Information Basic Information Ensembl ID: ENSMUSG00000050578 Description: matrix metallopeptidase 13 [Source:MGI Symbol;Acc:MGI:1340026] Location: 9:7272514-7283331 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Degradation of the extracellular matrix Collagen formation Pcolce2 Gene Information Basic Information Ensembl ID: ENSMUSG00000015354 Description: procollagen C-endopeptidase enhancer 2 [Source:MGI Symbol;Acc:MGI:1923727] Location: 9:95519654-95580149 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stem cell stromal cell Other: Collagen formation
Cytokine Signaling in Immune system Pathway Hierarchies & Genes Growth hormone receptor signaling (5 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-6 family signaling Interleukin-6 signaling 2 genes Prolactin receptor signaling Interferon Signaling Interferon gamma signaling Regulation of IFNG signaling 1 genes Signaling by CSF3 (G-CSF) 1 genes Inactivation of CSF3 (G-CSF) signaling Growth hormone receptor signaling 1 genes Inactivation of CSF3 (G-CSF) signaling (5 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-4 and Interleukin-13 signaling 4 genes Interferon Signaling Interferon gamma signaling Regulation of IFNG signaling Signaling by CSF3 (G-CSF) Inactivation of CSF3 (G-CSF) signaling 1 genes Inactivation of CSF3 (G-CSF) signaling (2 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-2 family signaling Interleukin-2 signaling 1 genes FLT3 Signaling FLT3 signaling through SRC family kinases Signaling by CSF3 (G-CSF) Inactivation of CSF3 (G-CSF) signaling 1 genes Growth hormone receptor signaling (4 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-3, Interleukin-5 and GM-CSF signaling Regulation of signaling by CBL 3 genes Signaling by CSF3 (G-CSF) Inactivation of CSF3 (G-CSF) signaling Growth hormone receptor signaling 1 genes Interleukin-1 signaling (6 genes) Immune System Cytokine Signaling in Immune system Interferon Signaling Antiviral mechanism by IFN-stimulated genes PKR-mediated signaling 4 genes Signaling by Interleukins Interleukin-1 family signaling 1 genes Interleukin-1 signaling 1 genes Interleukin-1 signaling (3 genes) Immune System Cytokine Signaling in Immune system Interferon Signaling Antiviral mechanism by IFN-stimulated genes ISG15 antiviral mechanism 2 genes Signaling by Interleukins Interleukin-1 family signaling Interleukin-1 signaling 1 genes Regulation of IFNA/IFNB signaling (2 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-2 family signaling Interleukin receptor SHC signaling 1 genes Interferon Signaling Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling 1 genes TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (11 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-1 family signaling Interleukin-1 signaling 10 genes TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 1 genes FLT3 Signaling (5 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-2 family signaling Interleukin-15 signaling 3 genes FLT3 Signaling 2 genes IL-6-type cytokine receptor ligand interactions (5 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-6 family signaling IL-6-type cytokine receptor ligand interactions 5 genes Interleukin-1 processing (4 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-1 family signaling Interleukin-1 processing 4 genes Interleukin-12 signaling (2 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-12 family signaling Interleukin-12 signaling 2 genes Interleukin-18 signaling (3 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-1 family signaling Interleukin-18 signaling 3 genes Interleukin-21 signaling (1 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-2 family signaling Interleukin-21 signaling 1 genes Interleukin-23 signaling (2 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-12 family signaling Interleukin-23 signaling 2 genes Interleukin-33 signaling (2 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-1 family signaling Interleukin-33 signaling 2 genes Interleukin-35 Signalling (2 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-12 family signaling Interleukin-35 Signalling 2 genes Interleukin-36 pathway (1 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-1 family signaling Interleukin-36 pathway 1 genes Interleukin-38 signaling (3 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-1 family signaling Interleukin-38 signaling 3 genes Interleukin-9 signaling (1 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-2 family signaling Interleukin-9 signaling 1 genes Regulation of IFNA/IFNB signaling (1 genes) Immune System Cytokine Signaling in Immune system Interferon Signaling Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling 1 genes Interleukin-10 signaling (2 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-10 signaling 2 genes Interleukin-17 signaling (2 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-17 signaling 2 genes Interleukin-20 family signaling (5 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-20 family signaling 5 genes Interleukin-7 signaling (3 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-7 signaling 3 genes Modulation of host responses by IFN-stimulated genes (1 genes) Immune System Cytokine Signaling in Immune system Interferon Signaling Modulation of host responses by IFN-stimulated genes 1 genes Negative regulation of FLT3 (2 genes) Immune System Cytokine Signaling in Immune system FLT3 Signaling Negative regulation of FLT3 2 genes Other interleukin signaling (4 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Other interleukin signaling 4 genes TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (2 genes) Immune System Cytokine Signaling in Immune system TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 2 genes TNFs bind their physiological receptors (7 genes) Immune System Cytokine Signaling in Immune system TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors 7 genes	Abl2 Gene Information Basic Information Ensembl ID: ENSMUSG00000026596 Description: ABL proto-oncogene 2%2C non-receptor tyrosine kinase [Source:MGI Symbol;Acc:MGI:87860] Location: 1:156386356-156477138 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: bone cell Other: Cytokine Signaling in Immune system Nervous system development Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Casp1 Gene Information Basic Information Ensembl ID: ENSMUSG00000025888 Description: caspase 1 [Source:MGI Symbol;Acc:MGI:96544] Location: 9:5298508-5307290 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Innate Immune System Regulated Necrosis Casp3 Gene Information Basic Information Ensembl ID: ENSMUSG00000031628 Description: caspase 3 [Source:MGI Symbol;Acc:MGI:107739] Location: 8:47070326-47092724 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell eosinophil Other: Apoptosis Cytokine Signaling in Immune system Signaling by Hippo Casp8 Gene Information Basic Information Ensembl ID: ENSMUSG00000026029 Description: caspase 8 [Source:MGI Symbol;Acc:MGI:1261423] Location: 1:58834533-58886662 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System Cd27 Gene Information Basic Information Ensembl ID: ENSMUSG00000030336 Description: CD27 antigen [Source:MGI Symbol;Acc:MGI:88326] Location: 6:125209585-125213973 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell hematopoietic stem cell Specialized T cell CD8+ T cell T cell memory B cell Other: Cytokine Signaling in Immune system Cdk1 Gene Information Basic Information Ensembl ID: ENSMUSG00000019942 Description: cyclin dependent kinase 1 [Source:MGI Symbol;Acc:MGI:88351] Location: 10:69170976-69188768 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: proliferative cell Other: Cytokine Signaling in Immune system Cilium Assembly MAPK family signaling cascades Creb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000025958 Description: cAMP responsive element binding protein 1 [Source:MGI Symbol;Acc:MGI:88494] Location: 1:64571804-64643707 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Transmission across Chemical Synapses Cytokine Signaling in Immune system Innate Immune System Crkl Gene Information Basic Information Ensembl ID: ENSMUSG00000006134 Description: v-crk avian sarcoma virus CT10 oncogene homolog-like [Source:MGI Symbol;Acc:MGI:104686] Location: 16:17269851-17305298 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Signaling by Erythropoietin Signaling by Receptor Tyrosine Kinases Csf1 Gene Information Basic Information Ensembl ID: ENSMUSG00000014599 Description: colony stimulating factor 1 (macrophage) [Source:MGI Symbol;Acc:MGI:1339753] Location: 3:107648364-107667785 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell endothelial cell basophil eosinophil Other: Cytokine Signaling in Immune system Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein modification Eda Gene Information Basic Information Ensembl ID: ENSMUSG00000059327 Description: ectodysplasin-A [Source:MGI Symbol;Acc:MGI:1195272] Location: X:99019212-99444368 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: preadipocyte mesenchymal cell Other: Cytokine Signaling in Immune system Eda2r Gene Information Basic Information Ensembl ID: ENSMUSG00000034457 Description: ectodysplasin A2 receptor [Source:MGI Symbol;Acc:MGI:2442860] Location: X:96377446-96420822 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Edaradd Gene Information Basic Information Ensembl ID: ENSMUSG00000095105 Description: EDAR associated via death domain [Source:MGI Symbol;Acc:MGI:1931001] Location: 13:12487513-12535319 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pancreatic cell Other: Cytokine Signaling in Immune system Fyn Gene Information Basic Information Ensembl ID: ENSMUSG00000019843 Description: Fyn proto-oncogene [Source:MGI Symbol;Acc:MGI:95602] Location: 10:39244851-39441377 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cell surface interactions at the vascular wall Nephrin family interactions Cytokine Signaling in Immune system Ifi44 Gene Information Basic Information Ensembl ID: ENSMUSG00000028037 Description: interferon-induced protein 44 [Source:MGI Symbol;Acc:MGI:2443016] Location: 3:151436559-151455597 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Cytokine Signaling in Immune system Ifnar1 Gene Information Basic Information Ensembl ID: ENSMUSG00000022967 Description: interferon (alpha and beta) receptor 1 [Source:MGI Symbol;Acc:MGI:107658] Location: 16:91282126-91304329 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Cytokine Signaling in Immune system Ifnlr1 Gene Information Basic Information Ensembl ID: ENSMUSG00000062157 Description: interferon lambda receptor 1 [Source:MGI Symbol;Acc:MGI:2429859] Location: 4:135413598-135435492 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Il10ra Gene Information Basic Information Ensembl ID: ENSMUSG00000032089 Description: interleukin 10 receptor%2C alpha [Source:MGI Symbol;Acc:MGI:96538] Location: 9:45165135-45180447 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell monocyte macrophage Other: Cytokine Signaling in Immune system Il10rb Gene Information Basic Information Ensembl ID: ENSMUSG00000022969 Description: interleukin 10 receptor%2C beta [Source:MGI Symbol;Acc:MGI:109380] Location: 16:91203052-91222722 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Cytokine Signaling in Immune system Il11 Gene Information Basic Information Ensembl ID: ENSMUSG00000004371 Description: interleukin 11 [Source:MGI Symbol;Acc:MGI:107613] Location: 7:4775372-4785858 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell Other: Cytokine Signaling in Immune system Il12b Gene Information Basic Information Ensembl ID: ENSMUSG00000004296 Description: interleukin 12b [Source:MGI Symbol;Acc:MGI:96540] Location: 11:44290890-44304860 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Il12rb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000000791 Description: interleukin 12 receptor%2C beta 1 [Source:MGI Symbol;Acc:MGI:104579] Location: 8:71261093-71274068 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Il12rb2 Gene Information Basic Information Ensembl ID: ENSMUSG00000018341 Description: interleukin 12 receptor%2C beta 2 [Source:MGI Symbol;Acc:MGI:1270861] Location: 6:67268302-67353172 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell Specialized T cell Other: Cytokine Signaling in Immune system Il13ra1 Gene Information Basic Information Ensembl ID: ENSMUSG00000017057 Description: interleukin 13 receptor%2C alpha 1 [Source:MGI Symbol;Acc:MGI:105052] Location: X:35375763-35434912 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell smooth muscle cell tuft cell Other: Cytokine Signaling in Immune system Il13ra2 Gene Information Basic Information Ensembl ID: ENSMUSG00000031289 Description: interleukin 13 receptor%2C alpha 2 [Source:MGI Symbol;Acc:MGI:1277954] Location: X:146166472-146212188 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Il15 Gene Information Basic Information Ensembl ID: ENSMUSG00000031712 Description: interleukin 15 [Source:MGI Symbol;Acc:MGI:103014] Location: 8:83058261-83129851 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell Other: Cytokine Signaling in Immune system Il16 Gene Information Basic Information Ensembl ID: ENSMUSG00000001741 Description: interleukin 16 [Source:MGI Symbol;Acc:MGI:1270855] Location: 7:83292033-83394934 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron lymphoid progenitor cell epithelial cell Other: Cytokine Signaling in Immune system Il18bp Gene Information Basic Information Ensembl ID: ENSMUSG00000070427 Description: interleukin 18 binding protein [Source:MGI Symbol;Acc:MGI:1333800] Location: 7:101664092-101667897 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte macrophage Other: Cytokine Signaling in Immune system Il18r1 Gene Information Basic Information Ensembl ID: ENSMUSG00000026070 Description: interleukin 18 receptor 1 [Source:MGI Symbol;Acc:MGI:105383] Location: 1:40504712-40540014 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell natural killer cell CD4+ T cell Specialized T cell innate lymphoid cell leukocyte Other: Cytokine Signaling in Immune system Il18rap Gene Information Basic Information Ensembl ID: ENSMUSG00000026068 Description: interleukin 18 receptor accessory protein [Source:MGI Symbol;Acc:MGI:1338888] Location: 1:40554522-40590865 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell natural killer cell eosinophil Specialized T cell Other: Cytokine Signaling in Immune system Il1a Gene Information Basic Information Ensembl ID: ENSMUSG00000027399 Description: interleukin 1 alpha [Source:MGI Symbol;Acc:MGI:96542] Location: 2:129141530-129151892 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte Other: Cytokine Signaling in Immune system Regulated Necrosis Il1b Gene Information Basic Information Ensembl ID: ENSMUSG00000027398 Description: interleukin 1 beta [Source:MGI Symbol;Acc:MGI:96543] Location: 2:129206490-129213059 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell dendritic cell phagocyte granulocyte myeloid cell erythroid lineage cell T cell leukocyte macrophage Other: Cytokine Signaling in Immune system Innate Immune System Regulated Necrosis Il1r1 Gene Information Basic Information Ensembl ID: ENSMUSG00000026072 Description: interleukin 1 receptor%2C type I [Source:MGI Symbol;Acc:MGI:96545] Location: 1:40264240-40356417 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell mural cell Other: Cytokine Signaling in Immune system Il1r2 Gene Information Basic Information Ensembl ID: ENSMUSG00000026073 Description: interleukin 1 receptor%2C type II [Source:MGI Symbol;Acc:MGI:96546] Location: 1:40113239-40164391 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell dendritic cell granulocyte monocyte Other: Cytokine Signaling in Immune system Il1rap Gene Information Basic Information Ensembl ID: ENSMUSG00000022514 Description: interleukin 1 receptor accessory protein [Source:MGI Symbol;Acc:MGI:104975] Location: 16:26400454-26548867 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell bipolar cell neuron Other: Cytokine Signaling in Immune system Protein-protein interactions at synapses Intracellular signaling by second messengers Il1rapl1 Gene Information Basic Information Ensembl ID: ENSMUSG00000052372 Description: interleukin 1 receptor accessory protein-like 1 [Source:MGI Symbol;Acc:MGI:2687319] Location: X:85784476-87159251 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron glial cell epithelial cell interneuron oligodendrocyte precursor cell Other: Protein-protein interactions at synapses Cytokine Signaling in Immune system Il1rl1 Gene Information Basic Information Ensembl ID: ENSMUSG00000026069 Description: interleukin 1 receptor-like 1 [Source:MGI Symbol;Acc:MGI:98427] Location: 1:40468730-40504575 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell natural killer cell mast cell Other: Cytokine Signaling in Immune system Intracellular signaling by second messengers Il1rl2 Gene Information Basic Information Ensembl ID: ENSMUSG00000070942 Description: interleukin 1 receptor-like 2 [Source:MGI Symbol;Acc:MGI:1913107] Location: 1:40363770-40406722 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast Other: Cytokine Signaling in Immune system Il1rn Gene Information Basic Information Ensembl ID: ENSMUSG00000026981 Description: interleukin 1 receptor antagonist [Source:MGI Symbol;Acc:MGI:96547] Location: 2:24226865-24241506 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell mast cell granulocyte macrophage Other: Cytokine Signaling in Immune system Il20ra Gene Information Basic Information Ensembl ID: ENSMUSG00000020007 Description: interleukin 20 receptor%2C alpha [Source:MGI Symbol;Acc:MGI:3605069] Location: 10:19588318-19635801 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Il20rb Gene Information Basic Information Ensembl ID: ENSMUSG00000044244 Description: interleukin 20 receptor beta [Source:MGI Symbol;Acc:MGI:2143266] Location: 9:100339772-100368841 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Il21r Gene Information Basic Information Ensembl ID: ENSMUSG00000030745 Description: interleukin 21 receptor [Source:MGI Symbol;Acc:MGI:1890475] Location: 7:125202601-125232742 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell Naive B cell hematopoietic stem cell Specialized T cell Other: Cytokine Signaling in Immune system Il22ra1 Gene Information Basic Information Ensembl ID: ENSMUSG00000037157 Description: interleukin 22 receptor%2C alpha 1 [Source:MGI Symbol;Acc:MGI:2663588] Location: 4:135455483-135479451 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Il22ra2 Gene Information Basic Information Ensembl ID: ENSMUSG00000039760 Description: interleukin 22 receptor%2C alpha 2 [Source:MGI Symbol;Acc:MGI:2665114] Location: 10:19497746-19510429 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Il23a Gene Information Basic Information Ensembl ID: ENSMUSG00000025383 Description: interleukin 23%2C alpha subunit p19 [Source:MGI Symbol;Acc:MGI:1932410] Location: 10:128132008-128134621 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Il23r Gene Information Basic Information Ensembl ID: ENSMUSG00000049093 Description: interleukin 23 receptor [Source:MGI Symbol;Acc:MGI:2181693] Location: 6:67399916-67468839 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Il27ra Gene Information Basic Information Ensembl ID: ENSMUSG00000005465 Description: interleukin 27 receptor%2C alpha [Source:MGI Symbol;Acc:MGI:1355318] Location: 8:84756923-84769218 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell CD4+ T cell Other: Cytokine Signaling in Immune system Il2ra Gene Information Basic Information Ensembl ID: ENSMUSG00000026770 Description: interleukin 2 receptor%2C alpha chain [Source:MGI Symbol;Acc:MGI:96549] Location: 2:11647618-11698004 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Regulatory T cell T cell CD8+ T cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades Il2rb Gene Information Basic Information Ensembl ID: ENSMUSG00000068227 Description: interleukin 2 receptor%2C beta chain [Source:MGI Symbol;Acc:MGI:96550] Location: 15:78363456-78379471 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell developing T cell Specialized T cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades Il2rg Gene Information Basic Information Ensembl ID: ENSMUSG00000031304 Description: interleukin 2 receptor%2C gamma chain [Source:MGI Symbol;Acc:MGI:96551] Location: X:100307984-100311861 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell developing T cell fibroblast Regulatory T cell CD4+ T cell endothelial cell hematopoietic cell innate lymphoid cell lymphocyte Other: Cytokine Signaling in Immune system MAPK family signaling cascades Il31ra Gene Information Basic Information Ensembl ID: ENSMUSG00000050377 Description: interleukin 31 receptor A [Source:MGI Symbol;Acc:MGI:2180511] Location: 13:112656432-112730894 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Il33 Gene Information Basic Information Ensembl ID: ENSMUSG00000024810 Description: interleukin 33 [Source:MGI Symbol;Acc:MGI:1924375] Location: 19:29902514-29938118 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stellate cell pneumocyte stem cell fibroblast epithelial cell glial cell oligodendrocyte Other: Cytokine Signaling in Immune system Post-translational protein modification Intracellular signaling by second messengers Il34 Gene Information Basic Information Ensembl ID: ENSMUSG00000031750 Description: interleukin 34 [Source:MGI Symbol;Acc:MGI:1923777] Location: 8:111468461-111532556 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte fibroblast Other: Cytokine Signaling in Immune system Il4ra Gene Information Basic Information Ensembl ID: ENSMUSG00000030748 Description: interleukin 4 receptor%2C alpha [Source:MGI Symbol;Acc:MGI:105367] Location: 7:125151292-125178646 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell macrophage Other: Cytokine Signaling in Immune system Il5ra Gene Information Basic Information Ensembl ID: ENSMUSG00000005364 Description: interleukin 5 receptor%2C alpha [Source:MGI Symbol;Acc:MGI:96558] Location: 6:106687318-106725998 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system MAPK family signaling cascades Il6ra Gene Information Basic Information Ensembl ID: ENSMUSG00000027947 Description: interleukin 6 receptor%2C alpha [Source:MGI Symbol;Acc:MGI:105304] Location: 3:89771366-89820503 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte monocyte Other: Cytokine Signaling in Immune system MAPK family signaling cascades Il6st Gene Information Basic Information Ensembl ID: ENSMUSG00000021756 Description: interleukin 6 signal transducer [Source:MGI Symbol;Acc:MGI:96560] Location: 13:112600604-112646620 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades Il7 Gene Information Basic Information Ensembl ID: ENSMUSG00000040329 Description: interleukin 7 [Source:MGI Symbol;Acc:MGI:96561] Location: 3:7635054-7678820 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Cytokine Signaling in Immune system Il7r Gene Information Basic Information Ensembl ID: ENSMUSG00000003882 Description: interleukin 7 receptor [Source:MGI Symbol;Acc:MGI:96562] Location: 15:9505874-9530262 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell CD8+ T cell dendritic cell developing T cell Regulatory T cell mast cell memory T cell effector T cell innate lymphoid cell Other: Cytokine Signaling in Immune system Membrane Trafficking Il9r Gene Information Basic Information Ensembl ID: ENSMUSG00000020279 Description: interleukin 9 receptor [Source:MGI Symbol;Acc:MGI:96564] Location: 11:32137541-32150279 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Ilf2 Gene Information Basic Information Ensembl ID: ENSMUSG00000001016 Description: interleukin enhancer binding factor 2 [Source:MGI Symbol;Acc:MGI:1915031] Location: 3:90383433-90395686 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stem cell Other: Cytokine Signaling in Immune system Innate Immune System Ilf3 Gene Information Basic Information Ensembl ID: ENSMUSG00000032178 Description: interleukin enhancer binding factor 3 [Source:MGI Symbol;Acc:MGI:1339973] Location: 9:21279167-21316657 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Cell junction organization Irak1 Gene Information Basic Information Ensembl ID: ENSMUSG00000031392 Description: interleukin-1 receptor-associated kinase 1 [Source:MGI Symbol;Acc:MGI:107420] Location: X:73057520-73067524 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Innate Immune System Death Receptor Signaling Irak4 Gene Information Basic Information Ensembl ID: ENSMUSG00000059883 Description: interleukin-1 receptor-associated kinase 4 [Source:MGI Symbol;Acc:MGI:2182474] Location: 15:94441524-94479696 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Intracellular signaling by second messengers Irs2 Gene Information Basic Information Ensembl ID: ENSMUSG00000038894 Description: insulin receptor substrate 2 [Source:MGI Symbol;Acc:MGI:109334] Location: 8:11034681-11058458 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: mural cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades Signaling by Erythropoietin Jak2 Gene Information Basic Information Ensembl ID: ENSMUSG00000024789 Description: Janus kinase 2 [Source:MGI Symbol;Acc:MGI:96629] Location: 19:29229228-29290480 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell dendritic cell eosinophil Other: Cytokine Signaling in Immune system MAPK family signaling cascades Cell Cycle, Mitotic Lif Gene Information Basic Information Ensembl ID: ENSMUSG00000034394 Description: leukemia inhibitory factor [Source:MGI Symbol;Acc:MGI:96787] Location: 11:4207557-4222514 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Lyn Gene Information Basic Information Ensembl ID: ENSMUSG00000042228 Description: LYN proto-oncogene%2C Src family tyrosine kinase [Source:MGI Symbol;Acc:MGI:96892] Location: 4:3678115-3813122 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Platelet Adhesion to exposed collagen Cytokine Signaling in Immune system Adaptive Immune System Map2k6 Gene Information Basic Information Ensembl ID: ENSMUSG00000020623 Description: mitogen-activated protein kinase kinase 6 [Source:MGI Symbol;Acc:MGI:1346870] Location: 11:110289948-110416348 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: bergmann glial cell skeletal muscle cell Other: Cytokine Signaling in Immune system Innate Immune System Cellular responses to stress Map3k7 Gene Information Basic Information Ensembl ID: ENSMUSG00000028284 Description: mitogen-activated protein kinase kinase kinase 7 [Source:MGI Symbol;Acc:MGI:1346877] Location: 4:31964097-32023467 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Mapk8 Gene Information Basic Information Ensembl ID: ENSMUSG00000021936 Description: mitogen-activated protein kinase 8 [Source:MGI Symbol;Acc:MGI:1346861] Location: 14:33099855-33169115 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System Mapt Gene Information Basic Information Ensembl ID: ENSMUSG00000018411 Description: microtubule-associated protein tau [Source:MGI Symbol;Acc:MGI:97180] Location: 11:104122216-104222916 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron pericyte epithelial cell skeletal muscle cell Other: Apoptosis Cytokine Signaling in Immune system Mx2 Gene Information Basic Information Ensembl ID: ENSMUSG00000023341 Description: MX dynamin-like GTPase 2 [Source:MGI Symbol;Acc:MGI:97244] Location: 16:97336508-97362100 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Myd88 Gene Information Basic Information Ensembl ID: ENSMUSG00000032508 Description: myeloid differentiation primary response gene 88 [Source:MGI Symbol;Acc:MGI:108005] Location: 9:119165000-119170477 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Innate Immune System Death Receptor Signaling Osm Gene Information Basic Information Ensembl ID: ENSMUSG00000058755 Description: oncostatin M [Source:MGI Symbol;Acc:MGI:104749] Location: 11:4186420-4191026 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell mast cell granulocyte erythroblast microglia Other: Cytokine Signaling in Immune system Osmr Gene Information Basic Information Ensembl ID: ENSMUSG00000022146 Description: oncostatin M receptor [Source:MGI Symbol;Acc:MGI:1330819] Location: 15:6843058-6904450 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Cytokine Signaling in Immune system Plcg1 Gene Information Basic Information Ensembl ID: ENSMUSG00000016933 Description: phospholipase C%2C gamma 1 [Source:MGI Symbol;Acc:MGI:97615] Location: 2:160573220-160617680 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Inositol phosphate metabolism Ppp2ca Gene Information Basic Information Ensembl ID: ENSMUSG00000020349 Description: protein phosphatase 2 (formerly 2A)%2C catalytic subunit%2C alpha isoform [Source:MGI Symbol;Acc:MGI:1321159] Location: 11:51989508-52018605 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Ptpn11 Gene Information Basic Information Ensembl ID: ENSMUSG00000043733 Description: protein tyrosine phosphatase%2C non-receptor type 11 [Source:MGI Symbol;Acc:MGI:99511] Location: 5:121268596-121329460 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Nervous system development Cytokine Signaling in Immune system Adaptive Immune System Ptpn6 Gene Information Basic Information Ensembl ID: ENSMUSG00000004266 Description: protein tyrosine phosphatase%2C non-receptor type 6 [Source:MGI Symbol;Acc:MGI:96055] Location: 6:124697670-124715677 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell Naive B cell tuft cell monocyte dendritic cell macrophage Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Rapgef1 Gene Information Basic Information Ensembl ID: ENSMUSG00000039844 Description: Rap guanine nucleotide exchange factor (GEF) 1 [Source:MGI Symbol;Acc:MGI:104580] Location: 2:29509732-29630990 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Specialized T cell oligodendrocyte precursor cell Other: Signaling by Erythropoietin Cytokine Signaling in Immune system Signaling by Receptor Tyrosine Kinases Rela Gene Information Basic Information Ensembl ID: ENSMUSG00000024927 Description: v-rel reticuloendotheliosis viral oncogene homolog A (avian) [Source:MGI Symbol;Acc:MGI:103290] Location: 19:5687511-5698158 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Ripk2 Gene Information Basic Information Ensembl ID: ENSMUSG00000041135 Description: receptor (TNFRSF)-interacting serine-threonine kinase 2 [Source:MGI Symbol;Acc:MGI:1891456] Location: 4:16122733-16163647 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Sh2b3 Gene Information Basic Information Ensembl ID: ENSMUSG00000042594 Description: SH2B adaptor protein 3 [Source:MGI Symbol;Acc:MGI:893598] Location: 5:121953551-121975709 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Signaling by Receptor Tyrosine Kinases Factors involved in megakaryocyte development and platelet production Shc1 Gene Information Basic Information Ensembl ID: ENSMUSG00000042626 Description: src homology 2 domain-containing transforming protein C1 [Source:MGI Symbol;Acc:MGI:98296] Location: 3:89325750-89337334 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Innate Immune System Cell surface interactions at the vascular wall Socs1 Gene Information Basic Information Ensembl ID: ENSMUSG00000038037 Description: suppressor of cytokine signaling 1 [Source:MGI Symbol;Acc:MGI:1354910] Location: 16:10600104-10603400 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell innate lymphoid cell Other: Cytokine Signaling in Immune system Adaptive Immune System Socs5 Gene Information Basic Information Ensembl ID: ENSMUSG00000037104 Description: suppressor of cytokine signaling 5 [Source:MGI Symbol;Acc:MGI:2385459] Location: 17:87415107-87445267 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Cytokine Signaling in Immune system Post-translational protein modification Sos1 Gene Information Basic Information Ensembl ID: ENSMUSG00000024241 Description: SOS Ras/Rac guanine nucleotide exchange factor 1 [Source:MGI Symbol;Acc:MGI:98354] Location: 17:80701180-80787882 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Syk Gene Information Basic Information Ensembl ID: ENSMUSG00000021457 Description: spleen tyrosine kinase [Source:MGI Symbol;Acc:MGI:99515] Location: 13:52737209-52802828 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell Naive B cell monocyte granulocyte Other: Integrin signaling Cytokine Signaling in Immune system Adaptive Immune System Tnfrsf11a Gene Information Basic Information Ensembl ID: ENSMUSG00000026321 Description: tumor necrosis factor receptor superfamily%2C member 11a%2C NFKB activator [Source:MGI Symbol;Acc:MGI:1314891] Location: 1:105708443-105775709 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte Other: Cytokine Signaling in Immune system Tnfsf13b Gene Information Basic Information Ensembl ID: ENSMUSG00000031497 Description: tumor necrosis factor (ligand) superfamily%2C member 13b [Source:MGI Symbol;Acc:MGI:1344376] Location: 8:10056467-10089072 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Tnfsf15 Gene Information Basic Information Ensembl ID: ENSMUSG00000050395 Description: tumor necrosis factor (ligand) superfamily%2C member 15 [Source:MGI Symbol;Acc:MGI:2180140] Location: 4:63642840-63663350 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Tnfsf8 Gene Information Basic Information Ensembl ID: ENSMUSG00000028362 Description: tumor necrosis factor (ligand) superfamily%2C member 8 [Source:MGI Symbol;Acc:MGI:88328] Location: 4:63749545-63779584 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Regulatory T cell Other: Cytokine Signaling in Immune system Tollip Gene Information Basic Information Ensembl ID: ENSMUSG00000025139 Description: toll interacting protein [Source:MGI Symbol;Acc:MGI:1891808] Location: 7:141428550-141472244 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Innate Immune System Traf2 Gene Information Basic Information Ensembl ID: ENSMUSG00000026942 Description: TNF receptor-associated factor 2 [Source:MGI Symbol;Acc:MGI:101835] Location: 2:25407994-25436952 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System Traf3 Gene Information Basic Information Ensembl ID: ENSMUSG00000021277 Description: TNF receptor-associated factor 3 [Source:MGI Symbol;Acc:MGI:108041] Location: 12:111132804-111233587 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Cytokine Signaling in Immune system Innate Immune System Post-translational protein modification Traf6 Gene Information Basic Information Ensembl ID: ENSMUSG00000027164 Description: TNF receptor-associated factor 6 [Source:MGI Symbol;Acc:MGI:108072] Location: 2:101508774-101532014 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Post-translational protein modification Cytokine Signaling in Immune system Adaptive Immune System Tyk2 Gene Information Basic Information Ensembl ID: ENSMUSG00000032175 Description: tyrosine kinase 2 [Source:MGI Symbol;Acc:MGI:1929470] Location: 9:21015364-21042539 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades Usp18 Gene Information Basic Information Ensembl ID: ENSMUSG00000030107 Description: ubiquitin specific peptidase 18 [Source:MGI Symbol;Acc:MGI:1344364] Location: 6:121222865-121247876 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Cytokine Signaling in Immune system Innate Immune System Post-translational protein modification
DNA Double-Strand Break Repair Pathway Hierarchies & Genes Nonhomologous End-Joining (NHEJ) (1 genes) DNA Repair DNA Double-Strand Break Repair Homology Directed Repair HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) Processing of DNA double-strand break ends DNA Double Strand Break Response Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) 1 genes Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (1 genes) DNA Repair DNA Double-Strand Break Repair Homology Directed Repair HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) HDR through Single Strand Annealing (SSA) DNA Double Strand Break Response Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 1 genes Resolution of D-loop Structures through Holliday Junction Intermediates (1 genes) DNA Repair DNA Double-Strand Break Repair Homology Directed Repair HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-Loop Structures Resolution of D-loop Structures through Holliday Junction Intermediates 1 genes Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (1 genes) DNA Repair DNA Double-Strand Break Repair DNA Double Strand Break Response Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 1 genes	Abl1 Gene Information Basic Information Ensembl ID: ENSMUSG00000026842 Description: c-abl oncogene 1%2C non-receptor tyrosine kinase [Source:MGI Symbol;Acc:MGI:87859] Location: 2:31578388-31694239 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Epigenetic regulation of gene expression Myogenesis Babam2 Gene Information Basic Information Ensembl ID: ENSMUSG00000052139 Description: BRISC and BRCA1 A complex member 2 [Source:MGI Symbol;Acc:MGI:1333875] Location: 5:31855028-32242306 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: DNA Double-Strand Break Repair Post-translational protein modification Cell Cycle Checkpoints Mapk8 Gene Information Basic Information Ensembl ID: ENSMUSG00000021936 Description: mitogen-activated protein kinase 8 [Source:MGI Symbol;Acc:MGI:1346861] Location: 14:33099855-33169115 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System Rad51b Gene Information Basic Information Ensembl ID: ENSMUSG00000059060 Description: RAD51 paralog B [Source:MGI Symbol;Acc:MGI:1099436] Location: 12:79344056-79861464 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell endothelial cell Other: DNA Double-Strand Break Repair Factors involved in megakaryocyte development and platelet production
DNA Replication Pre-Initiation Pathway Hierarchies & Genes Activation of the pre-replicative complex (1 genes) DNA Replication DNA Replication Pre-Initiation Activation of the pre-replicative complex 1 genes	Cdc45 Gene Information Basic Information Ensembl ID: ENSMUSG00000000028 Description: cell division cycle 45 [Source:MGI Symbol;Acc:MGI:1338073] Location: 16:18599197-18630737 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: DNA Replication Pre-Initiation Cell Cycle, Mitotic Cell Cycle Checkpoints
Death Receptor Signaling Pathway Hierarchies & Genes TRAIL signaling (4 genes) Signal Transduction Death Receptor Signaling TNF signaling TNFR1-induced proapoptotic signaling 3 genes FasL/ CD95L signaling TRAIL signaling 1 genes TRAIL signaling (3 genes) Signal Transduction Death Receptor Signaling TNF signaling Regulation of TNFR1 signaling 2 genes FasL/ CD95L signaling TRAIL signaling 1 genes Axonal growth inhibition (RHOA activation) (1 genes) Signal Transduction Death Receptor Signaling p75 NTR receptor-mediated signalling p75NTR regulates axonogenesis Axonal growth inhibition (RHOA activation) 1 genes NADE modulates death signalling (1 genes) Signal Transduction Death Receptor Signaling p75 NTR receptor-mediated signalling Cell death signalling via NRAGE, NRIF and NADE NADE modulates death signalling 1 genes NF-kB is activated and signals survival (1 genes) Signal Transduction Death Receptor Signaling p75 NTR receptor-mediated signalling p75NTR signals via NF-kB NF-kB is activated and signals survival 1 genes NRAGE signals death through JNK (7 genes) Signal Transduction Death Receptor Signaling p75 NTR receptor-mediated signalling Cell death signalling via NRAGE, NRIF and NADE NRAGE signals death through JNK 7 genes NRIF signals cell death from the nucleus (2 genes) Signal Transduction Death Receptor Signaling p75 NTR receptor-mediated signalling Cell death signalling via NRAGE, NRIF and NADE NRIF signals cell death from the nucleus 2 genes TNF signaling (1 genes) Signal Transduction Death Receptor Signaling p75 NTR receptor-mediated signalling Regulated proteolysis of p75NTR TNF signaling 1 genes p75NTR recruits signalling complexes (3 genes) Signal Transduction Death Receptor Signaling p75 NTR receptor-mediated signalling p75NTR signals via NF-kB p75NTR recruits signalling complexes 3 genes TNFR1-induced NF-kappa-B signaling pathway (1 genes) Signal Transduction Death Receptor Signaling TNF signaling TNFR1-induced NF-kappa-B signaling pathway 1 genes TNFR1-mediated ceramide production (2 genes) Signal Transduction Death Receptor Signaling TNF signaling TNFR1-mediated ceramide production 2 genes FasL/ CD95L signaling (1 genes) Signal Transduction Death Receptor Signaling FasL/ CD95L signaling 1 genes TRAIL signaling (2 genes) Signal Transduction Death Receptor Signaling TRAIL signaling 2 genes	Adam17 Gene Information Basic Information Ensembl ID: ENSMUSG00000052593 Description: a disintegrin and metallopeptidase domain 17 [Source:MGI Symbol;Acc:MGI:1096335] Location: 12:21373510-21423633 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Death Receptor Signaling Arhgef1 Gene Information Basic Information Ensembl ID: ENSMUSG00000040940 Description: Rho guanine nucleotide exchange factor 1 [Source:MGI Symbol;Acc:MGI:1353510] Location: 7:24602337-24626019 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell CD4+ T cell Specialized T cell CD8+ T cell lymphocyte Other: Signaling by GPCR Death Receptor Signaling Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Arhgef11 Gene Information Basic Information Ensembl ID: ENSMUSG00000041977 Description: Rho guanine nucleotide exchange factor 11 [Source:MGI Symbol;Acc:MGI:2441869] Location: 3:87524866-87645341 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by GPCR Death Receptor Signaling Nervous system development Arhgef2 Gene Information Basic Information Ensembl ID: ENSMUSG00000028059 Description: Rho/Rac guanine nucleotide exchange factor 2 [Source:MGI Symbol;Acc:MGI:103264] Location: 3:88513273-88555359 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Death Receptor Signaling Signaling by GPCR Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Bcl2l11 Gene Information Basic Information Ensembl ID: ENSMUSG00000027381 Description: BCL2 like 11 [Source:MGI Symbol;Acc:MGI:1197519] Location: 2:127967958-128004467 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Apoptosis Death Receptor Signaling Casp3 Gene Information Basic Information Ensembl ID: ENSMUSG00000031628 Description: caspase 3 [Source:MGI Symbol;Acc:MGI:107739] Location: 8:47070326-47092724 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell eosinophil Other: Apoptosis Cytokine Signaling in Immune system Signaling by Hippo Casp8 Gene Information Basic Information Ensembl ID: ENSMUSG00000026029 Description: caspase 8 [Source:MGI Symbol;Acc:MGI:1261423] Location: 1:58834533-58886662 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System Fadd Gene Information Basic Information Ensembl ID: ENSMUSG00000031077 Description: Fas associated via death domain [Source:MGI Symbol;Acc:MGI:109324] Location: 7:144131055-144136200 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Apoptosis Innate Immune System Regulated Necrosis Fasl Gene Information Basic Information Ensembl ID: ENSMUSG00000000817 Description: Fas ligand [Source:MGI Symbol;Acc:MGI:99255] Location: 1:161608258-161616064 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell CD8+ T cell T cell Other: Apoptosis Regulated Necrosis Death Receptor Signaling Gna13 Gene Information Basic Information Ensembl ID: ENSMUSG00000020611 Description: guanine nucleotide binding protein%2C alpha 13 [Source:MGI Symbol;Acc:MGI:95768] Location: 11:109253657-109292195 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell developing T cell innate lymphoid cell Other: Signaling by GPCR Death Receptor Signaling Platelet activation, signaling and aggregation Irak1 Gene Information Basic Information Ensembl ID: ENSMUSG00000031392 Description: interleukin-1 receptor-associated kinase 1 [Source:MGI Symbol;Acc:MGI:107420] Location: X:73057520-73067524 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Innate Immune System Death Receptor Signaling Map3k7 Gene Information Basic Information Ensembl ID: ENSMUSG00000028284 Description: mitogen-activated protein kinase kinase kinase 7 [Source:MGI Symbol;Acc:MGI:1346877] Location: 4:31964097-32023467 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Mapk8 Gene Information Basic Information Ensembl ID: ENSMUSG00000021936 Description: mitogen-activated protein kinase 8 [Source:MGI Symbol;Acc:MGI:1346861] Location: 14:33099855-33169115 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System Myd88 Gene Information Basic Information Ensembl ID: ENSMUSG00000032508 Description: myeloid differentiation primary response gene 88 [Source:MGI Symbol;Acc:MGI:108005] Location: 9:119165000-119170477 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Innate Immune System Death Receptor Signaling Ngfr Gene Information Basic Information Ensembl ID: ENSMUSG00000000120 Description: nerve growth factor receptor (TNFR superfamily%2C member 16) [Source:MGI Symbol;Acc:MGI:97323] Location: 11:95459644-95478561 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Death Receptor Signaling Nsmaf Gene Information Basic Information Ensembl ID: ENSMUSG00000028245 Description: neutral sphingomyelinase (N-SMase) activation associated factor [Source:MGI Symbol;Acc:MGI:1341864] Location: 4:6396207-6454271 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell Other: Death Receptor Signaling Psen1 Gene Information Basic Information Ensembl ID: ENSMUSG00000019969 Description: presenilin 1 [Source:MGI Symbol;Acc:MGI:1202717] Location: 12:83734926-83781973 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Signaling by NOTCH Death Receptor Signaling Rela Gene Information Basic Information Ensembl ID: ENSMUSG00000024927 Description: v-rel reticuloendotheliosis viral oncogene homolog A (avian) [Source:MGI Symbol;Acc:MGI:103290] Location: 19:5687511-5698158 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Ripk1 Gene Information Basic Information Ensembl ID: ENSMUSG00000021408 Description: receptor (TNFRSF)-interacting serine-threonine kinase 1 [Source:MGI Symbol;Acc:MGI:108212] Location: 13:34186346-34221130 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Apoptosis Innate Immune System Regulated Necrosis Ripk2 Gene Information Basic Information Ensembl ID: ENSMUSG00000041135 Description: receptor (TNFRSF)-interacting serine-threonine kinase 2 [Source:MGI Symbol;Acc:MGI:1891456] Location: 4:16122733-16163647 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Smpd3 Gene Information Basic Information Ensembl ID: ENSMUSG00000031906 Description: sphingomyelin phosphodiesterase 3%2C neutral [Source:MGI Symbol;Acc:MGI:1927578] Location: 8:106979180-107064620 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endocrine cell fibroblast osteoblast Other: Metabolism of lipids Death Receptor Signaling Sos1 Gene Information Basic Information Ensembl ID: ENSMUSG00000024241 Description: SOS Ras/Rac guanine nucleotide exchange factor 1 [Source:MGI Symbol;Acc:MGI:98354] Location: 17:80701180-80787882 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Stub1 Gene Information Basic Information Ensembl ID: ENSMUSG00000039615 Description: STIP1 homology and U-Box containing protein 1 [Source:MGI Symbol;Acc:MGI:1891731] Location: 17:26049479-26052378 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Adaptive Immune System Regulated Necrosis RNA Polymerase II Transcription Tnfrsf10b Gene Information Basic Information Ensembl ID: ENSMUSG00000022074 Description: tumor necrosis factor receptor superfamily%2C member 10b [Source:MGI Symbol;Acc:MGI:1341090] Location: 14:70004921-70021860 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Apoptosis Cell surface interactions at the vascular wall Regulated Necrosis Tnfsf10 Gene Information Basic Information Ensembl ID: ENSMUSG00000039304 Description: tumor necrosis factor (ligand) superfamily%2C member 10 [Source:MGI Symbol;Acc:MGI:107414] Location: 3:27371177-27396576 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Apoptosis Regulated Necrosis Death Receptor Signaling Traf1 Gene Information Basic Information Ensembl ID: ENSMUSG00000026875 Description: TNF receptor-associated factor 1 [Source:MGI Symbol;Acc:MGI:101836] Location: 2:34831762-34851784 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell phagocyte CD4+ T cell Other: Death Receptor Signaling Traf2 Gene Information Basic Information Ensembl ID: ENSMUSG00000026942 Description: TNF receptor-associated factor 2 [Source:MGI Symbol;Acc:MGI:101835] Location: 2:25407994-25436952 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System Traf6 Gene Information Basic Information Ensembl ID: ENSMUSG00000027164 Description: TNF receptor-associated factor 6 [Source:MGI Symbol;Acc:MGI:108072] Location: 2:101508774-101532014 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Post-translational protein modification Cytokine Signaling in Immune system Adaptive Immune System Usp4 Gene Information Basic Information Ensembl ID: ENSMUSG00000032612 Description: ubiquitin specific peptidase 4 (proto-oncogene) [Source:MGI Symbol;Acc:MGI:98905] Location: 9:108225052-108269744 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Post-translational protein modification Death Receptor Signaling
Degradation of the extracellular matrix Pathway Hierarchies & Genes Activation of Matrix Metalloproteinases (14 genes) Extracellular matrix organization Degradation of the extracellular matrix 3 genes Collagen degradation 8 genes Activation of Matrix Metalloproteinases 3 genes Collagen degradation (1 genes) Extracellular matrix organization Degradation of the extracellular matrix Collagen degradation 1 genes	Adam8 Gene Information Basic Information Ensembl ID: ENSMUSG00000025473 Description: a disintegrin and metallopeptidase domain 8 [Source:MGI Symbol;Acc:MGI:107825] Location: 7:139558845-139572475 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell phagocyte dendritic cell granulocyte neutrophil Other: Degradation of the extracellular matrix Innate Immune System Cd44 Gene Information Basic Information Ensembl ID: ENSMUSG00000005087 Description: CD44 antigen [Source:MGI Symbol;Acc:MGI:88338] Location: 2:102641486-102732010 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell phagocyte monocyte granulocyte neutrophil macrophage progenitor cell Other: Cell surface interactions at the vascular wall Integrin cell surface interactions Innate Immune System Col12a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000032332 Description: collagen%2C type XII%2C alpha 1 [Source:MGI Symbol;Acc:MGI:88448] Location: 9:79506273-79626113 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast endothelial cell Other: Degradation of the extracellular matrix Collagen formation Col13a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000058806 Description: collagen%2C type XIII%2C alpha 1 [Source:MGI Symbol;Acc:MGI:1277201] Location: 10:61674015-61814887 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast endothelial cell osteoblast Other: Degradation of the extracellular matrix Collagen formation Integrin cell surface interactions Col15a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000028339 Description: collagen%2C type XV%2C alpha 1 [Source:MGI Symbol;Acc:MGI:88449] Location: 4:47208161-47313167 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast endothelial cell pericyte Other: Degradation of the extracellular matrix Collagen formation Col1a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000001506 Description: collagen%2C type I%2C alpha 1 [Source:MGI Symbol;Acc:MGI:88467] Location: 11:94827050-94843868 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stellate cell pericyte stromal cell stem cell valve interstitial cell mesenchymal cell endothelial cell Other: ECM proteoglycans Platelet Adhesion to exposed collagen Adaptive Immune System Col1a2 Gene Information Basic Information Ensembl ID: ENSMUSG00000029661 Description: collagen%2C type I%2C alpha 2 [Source:MGI Symbol;Acc:MGI:88468] Location: 6:4504814-4541544 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stellate cell pericyte stem cell stromal cell epithelial cell vascular cell meningeal cell Other: Adaptive Immune System Degradation of the extracellular matrix Collagen formation Col5a2 Gene Information Basic Information Ensembl ID: ENSMUSG00000026042 Description: collagen%2C type V%2C alpha 2 [Source:MGI Symbol;Acc:MGI:88458] Location: 1:45413481-45542442 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast pericyte stellate cell stromal cell mesenchymal cell Other: Degradation of the extracellular matrix Collagen formation Fibronectin matrix formation Col6a2 Gene Information Basic Information Ensembl ID: ENSMUSG00000020241 Description: collagen%2C type VI%2C alpha 2 [Source:MGI Symbol;Acc:MGI:88460] Location: 10:76431596-76459464 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stellate cell pericyte pneumocyte stromal cell epithelial cell Other: Degradation of the extracellular matrix Collagen formation Integrin cell surface interactions Col6a3 Gene Information Basic Information Ensembl ID: ENSMUSG00000048126 Description: collagen%2C type VI%2C alpha 3 [Source:MGI Symbol;Acc:MGI:88461] Location: 1:90693645-90771693 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast pericyte stellate cell stromal cell Other: Degradation of the extracellular matrix Collagen formation Integrin cell surface interactions Mmp12 Gene Information Basic Information Ensembl ID: ENSMUSG00000049723 Description: matrix metallopeptidase 12 [Source:MGI Symbol;Acc:MGI:97005] Location: 9:7344381-7369499 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte antigen presenting cell macrophage Other: Degradation of the extracellular matrix Mmp13 Gene Information Basic Information Ensembl ID: ENSMUSG00000050578 Description: matrix metallopeptidase 13 [Source:MGI Symbol;Acc:MGI:1340026] Location: 9:7272514-7283331 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Degradation of the extracellular matrix Collagen formation Mmp2 Gene Information Basic Information Ensembl ID: ENSMUSG00000031740 Description: matrix metallopeptidase 2 [Source:MGI Symbol;Acc:MGI:97009] Location: 8:93553919-93580048 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Degradation of the extracellular matrix Signaling by Nuclear Receptors Nervous system development Mmp8 Gene Information Basic Information Ensembl ID: ENSMUSG00000005800 Description: matrix metallopeptidase 8 [Source:MGI Symbol;Acc:MGI:1202395] Location: 9:7558457-7568486 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell granulocyte monocyte Other: Degradation of the extracellular matrix Innate Immune System Nid1 Gene Information Basic Information Ensembl ID: ENSMUSG00000005397 Description: nidogen 1 [Source:MGI Symbol;Acc:MGI:97342] Location: 13:13612136-13686854 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast pericyte stem cell glial cell stromal cell Other: Degradation of the extracellular matrix Laminin interactions
Dissolution of Fibrin Clot Pathway Hierarchies & Genes Dissolution of Fibrin Clot (3 genes) Hemostasis Dissolution of Fibrin Clot 3 genes	Anxa2 Gene Information Basic Information Ensembl ID: ENSMUSG00000032231 Description: annexin A2 [Source:MGI Symbol;Acc:MGI:88246] Location: 9:69360902-69399077 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell endothelial cell natural killer cell stem cell epithelial cell monocyte Other: Innate Immune System Dissolution of Fibrin Clot Cellular responses to mechanical stimuli Plat Gene Information Basic Information Ensembl ID: ENSMUSG00000031538 Description: plasminogen activator%2C tissue [Source:MGI Symbol;Acc:MGI:97610] Location: 8:23247743-23272860 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast endothelial cell pericyte epithelial cell stromal cell smooth muscle cell Other: Dissolution of Fibrin Clot Signaling by Receptor Tyrosine Kinases Serpine2 Gene Information Basic Information Ensembl ID: ENSMUSG00000026249 Description: serine (or cysteine) peptidase inhibitor%2C clade E%2C member 2 [Source:MGI Symbol;Acc:MGI:101780] Location: 1:79771914-79838897 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast pericyte glial cell stromal cell smooth muscle cell epithelial cell oligodendrocyte precursor cell schwann cell Other: Formation of Fibrin Clot (Clotting Cascade) Dissolution of Fibrin Clot
ECM proteoglycans Pathway Hierarchies & Genes ECM proteoglycans (15 genes) Extracellular matrix organization ECM proteoglycans 15 genes	Col1a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000001506 Description: collagen%2C type I%2C alpha 1 [Source:MGI Symbol;Acc:MGI:88467] Location: 11:94827050-94843868 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stellate cell pericyte stromal cell stem cell valve interstitial cell mesenchymal cell endothelial cell Other: ECM proteoglycans Platelet Adhesion to exposed collagen Adaptive Immune System Col1a2 Gene Information Basic Information Ensembl ID: ENSMUSG00000029661 Description: collagen%2C type I%2C alpha 2 [Source:MGI Symbol;Acc:MGI:88468] Location: 6:4504814-4541544 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stellate cell pericyte stem cell stromal cell epithelial cell vascular cell meningeal cell Other: Adaptive Immune System Degradation of the extracellular matrix Collagen formation Col5a2 Gene Information Basic Information Ensembl ID: ENSMUSG00000026042 Description: collagen%2C type V%2C alpha 2 [Source:MGI Symbol;Acc:MGI:88458] Location: 1:45413481-45542442 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast pericyte stellate cell stromal cell mesenchymal cell Other: Degradation of the extracellular matrix Collagen formation Fibronectin matrix formation Col6a2 Gene Information Basic Information Ensembl ID: ENSMUSG00000020241 Description: collagen%2C type VI%2C alpha 2 [Source:MGI Symbol;Acc:MGI:88460] Location: 10:76431596-76459464 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stellate cell pericyte pneumocyte stromal cell epithelial cell Other: Degradation of the extracellular matrix Collagen formation Integrin cell surface interactions Col6a3 Gene Information Basic Information Ensembl ID: ENSMUSG00000048126 Description: collagen%2C type VI%2C alpha 3 [Source:MGI Symbol;Acc:MGI:88461] Location: 1:90693645-90771693 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast pericyte stellate cell stromal cell Other: Degradation of the extracellular matrix Collagen formation Integrin cell surface interactions Itga2 Gene Information Basic Information Ensembl ID: ENSMUSG00000015533 Description: integrin alpha 2 [Source:MGI Symbol;Acc:MGI:96600] Location: 13:114969617-115068636 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Specialized T cell Other: Integrin cell surface interactions Non-integrin membrane-ECM interactions ECM proteoglycans Itga2b Gene Information Basic Information Ensembl ID: ENSMUSG00000034664 Description: integrin alpha 2b [Source:MGI Symbol;Acc:MGI:96601] Location: 11:102344123-102360948 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stromal cell mast cell megakaryocyte erythrocyte progenitor cell basophil stellate cell Other: Integrin cell surface interactions ECM proteoglycans Integrin signaling Itga7 Gene Information Basic Information Ensembl ID: ENSMUSG00000025348 Description: integrin alpha 7 [Source:MGI Symbol;Acc:MGI:102700] Location: 10:128769645-128794155 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: mural cell Other: Laminin interactions ECM proteoglycans Itga8 Gene Information Basic Information Ensembl ID: ENSMUSG00000026768 Description: integrin alpha 8 [Source:MGI Symbol;Acc:MGI:109442] Location: 2:12111443-12306733 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast smooth muscle cell epithelial cell mesenchymal stem cell Other: Elastic fibre formation Integrin cell surface interactions ECM proteoglycans Itga9 Gene Information Basic Information Ensembl ID: ENSMUSG00000039115 Description: integrin alpha 9 [Source:MGI Symbol;Acc:MGI:104756] Location: 9:118435758-118730071 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stromal cell pneumocyte Other: Integrin cell surface interactions ECM proteoglycans Nervous system development Itgav Gene Information Basic Information Ensembl ID: ENSMUSG00000027087 Description: integrin alpha V [Source:MGI Symbol;Acc:MGI:96608] Location: 2:83554741-83637260 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell bone cell Other: ECM proteoglycans Non-integrin membrane-ECM interactions Adaptive Immune System Itgax Gene Information Basic Information Ensembl ID: ENSMUSG00000030789 Description: integrin alpha X [Source:MGI Symbol;Acc:MGI:96609] Location: 7:127728719-127749829 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell phagocyte macrophage dendritic cell Other: Innate Immune System Cell surface interactions at the vascular wall Integrin cell surface interactions Itgb3 Gene Information Basic Information Ensembl ID: ENSMUSG00000020689 Description: integrin beta 3 [Source:MGI Symbol;Acc:MGI:96612] Location: 11:104498826-104561302 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell stromal cell bone cell megakaryocyte Other: Elastic fibre formation Cell surface interactions at the vascular wall Integrin cell surface interactions Tnc Gene Information Basic Information Ensembl ID: ENSMUSG00000028364 Description: tenascin C [Source:MGI Symbol;Acc:MGI:101922] Location: 4:63878022-63965252 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell fibroblast epithelial cell glial cell smooth muscle cell Other: Integrin cell surface interactions ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Tnxb Gene Information Basic Information Ensembl ID: ENSMUSG00000033327 Description: tenascin XB [Source:MGI Symbol;Acc:MGI:1932137] Location: 17:34879431-34938789 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stromal cell chondrocyte Other: ECM proteoglycans
Elastic fibre formation Pathway Hierarchies & Genes Molecules associated with elastic fibres (8 genes) Extracellular matrix organization Elastic fibre formation 1 genes Molecules associated with elastic fibres 7 genes	Bmp4 Gene Information Basic Information Ensembl ID: ENSMUSG00000021835 Description: bone morphogenetic protein 4 [Source:MGI Symbol;Acc:MGI:88180] Location: 14:46620977-46628126 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stem cell fibroblast epithelial cell smooth muscle cell ectodermal cell endothelial cell mesodermal cell Other: Elastic fibre formation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein modification Itga5 Gene Information Basic Information Ensembl ID: ENSMUSG00000000555 Description: integrin alpha 5 (fibronectin receptor alpha) [Source:MGI Symbol;Acc:MGI:96604] Location: 15:103252713-103275190 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Elastic fibre formation Fibronectin matrix formation Cell surface interactions at the vascular wall Itga8 Gene Information Basic Information Ensembl ID: ENSMUSG00000026768 Description: integrin alpha 8 [Source:MGI Symbol;Acc:MGI:109442] Location: 2:12111443-12306733 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast smooth muscle cell epithelial cell mesenchymal stem cell Other: Elastic fibre formation Integrin cell surface interactions ECM proteoglycans Itgav Gene Information Basic Information Ensembl ID: ENSMUSG00000027087 Description: integrin alpha V [Source:MGI Symbol;Acc:MGI:96608] Location: 2:83554741-83637260 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell bone cell Other: ECM proteoglycans Non-integrin membrane-ECM interactions Adaptive Immune System Itgb3 Gene Information Basic Information Ensembl ID: ENSMUSG00000020689 Description: integrin beta 3 [Source:MGI Symbol;Acc:MGI:96612] Location: 11:104498826-104561302 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell stromal cell bone cell megakaryocyte Other: Elastic fibre formation Cell surface interactions at the vascular wall Integrin cell surface interactions Tgfb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000002603 Description: transforming growth factor%2C beta 1 [Source:MGI Symbol;Acc:MGI:98725] Location: 7:25386427-25404502 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell hematopoietic stem cell phagocyte monocyte leukocyte megakaryocyte Other: Cell surface interactions at the vascular wall Non-integrin membrane-ECM interactions Elastic fibre formation Tgfb2 Gene Information Basic Information Ensembl ID: ENSMUSG00000039239 Description: transforming growth factor%2C beta 2 [Source:MGI Symbol;Acc:MGI:98726] Location: 1:186354989-186438186 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: glial cell endothelial cell astrocyte Other: Elastic fibre formation Platelet activation, signaling and aggregation Signaling by TGFB family members Tgfb3 Gene Information Basic Information Ensembl ID: ENSMUSG00000021253 Description: transforming growth factor%2C beta 3 [Source:MGI Symbol;Acc:MGI:98727] Location: 12:86103519-86125815 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: mesothelial cell Other: Elastic fibre formation Platelet activation, signaling and aggregation Signaling by TGFB family members
Epigenetic regulation of gene expression Pathway Hierarchies & Genes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis (1 genes) Gene expression (Transcription) Epigenetic regulation of gene expression Epigenetic regulation by WDR5-containing histone modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis 1 genes B-WICH complex positively regulates rRNA expression (1 genes) Gene expression (Transcription) Epigenetic regulation of gene expression Positive epigenetic regulation of rRNA expression B-WICH complex positively regulates rRNA expression 1 genes Formation of WDR5-containing histone-modifying complexes (1 genes) Gene expression (Transcription) Epigenetic regulation of gene expression Epigenetic regulation by WDR5-containing histone modifying complexes Formation of WDR5-containing histone-modifying complexes 1 genes	Abl1 Gene Information Basic Information Ensembl ID: ENSMUSG00000026842 Description: c-abl oncogene 1%2C non-receptor tyrosine kinase [Source:MGI Symbol;Acc:MGI:87859] Location: 2:31578388-31694239 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Epigenetic regulation of gene expression Myogenesis Gsk3b Gene Information Basic Information Ensembl ID: ENSMUSG00000022812 Description: glycogen synthase kinase 3 beta [Source:MGI Symbol;Acc:MGI:1861437] Location: 16:37909363-38066446 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by WNT Epigenetic regulation of gene expression Cellular responses to stress Men1 Gene Information Basic Information Ensembl ID: ENSMUSG00000024947 Description: multiple endocrine neoplasia 1 [Source:MGI Symbol;Acc:MGI:1316736] Location: 19:6385009-6390921 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by WNT Epigenetic regulation of gene expression Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Factors involved in megakaryocyte development and platelet production Pathway Hierarchies & Genes Kinesins (8 genes) Hemostasis Factors involved in megakaryocyte development and platelet production 7 genes Kinesins 1 genes	Cdc42 Gene Information Basic Information Ensembl ID: ENSMUSG00000006699 Description: cell division cycle 42 [Source:MGI Symbol;Acc:MGI:106211] Location: 4:137047007-137085031 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: hematopoietic stem cell phagocyte antigen presenting cell macrophage dendritic cell Other: Adaptive Immune System Innate Immune System Signaling by GPCR Dock10 Gene Information Basic Information Ensembl ID: ENSMUSG00000038608 Description: dedicator of cytokinesis 10 [Source:MGI Symbol;Acc:MGI:2146320] Location: 1:80478790-80736244 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell developing T cell hematopoietic stem cell dendritic cell antigen presenting cell Specialized T cell monocyte oligodendrocyte Other: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Factors involved in megakaryocyte development and platelet production Gata3 Gene Information Basic Information Ensembl ID: ENSMUSG00000015619 Description: GATA binding protein 3 [Source:MGI Symbol;Acc:MGI:95663] Location: 2:9861889-9894845 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Regulatory T cell epithelial cell stem cell CD4+ T cell innate lymphoid cell developing T cell mesangial cell Other: Post-translational protein modification RNA Polymerase II Transcription Signaling by Nuclear Receptors Gata6 Gene Information Basic Information Ensembl ID: ENSMUSG00000005836 Description: GATA binding protein 6 [Source:MGI Symbol;Acc:MGI:107516] Location: 18:11052064-11085635 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast smooth muscle cell cardiomyocyte pancreatic cell endodermal cell epithelial cell Other: Surfactant metabolism Factors involved in megakaryocyte development and platelet production Jak2 Gene Information Basic Information Ensembl ID: ENSMUSG00000024789 Description: Janus kinase 2 [Source:MGI Symbol;Acc:MGI:96629] Location: 19:29229228-29290480 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell dendritic cell eosinophil Other: Cytokine Signaling in Immune system MAPK family signaling cascades Cell Cycle, Mitotic Kif16b Gene Information Basic Information Ensembl ID: ENSMUSG00000038844 Description: kinesin family member 16B [Source:MGI Symbol;Acc:MGI:1098240] Location: 2:142459394-142743451 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Adaptive Immune System Membrane Trafficking Factors involved in megakaryocyte development and platelet production Rad51b Gene Information Basic Information Ensembl ID: ENSMUSG00000059060 Description: RAD51 paralog B [Source:MGI Symbol;Acc:MGI:1099436] Location: 12:79344056-79861464 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell endothelial cell Other: DNA Double-Strand Break Repair Factors involved in megakaryocyte development and platelet production Sh2b3 Gene Information Basic Information Ensembl ID: ENSMUSG00000042594 Description: SH2B adaptor protein 3 [Source:MGI Symbol;Acc:MGI:893598] Location: 5:121953551-121975709 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Signaling by Receptor Tyrosine Kinases Factors involved in megakaryocyte development and platelet production
Fibronectin matrix formation Pathway Hierarchies & Genes Fibronectin matrix formation (4 genes) Extracellular matrix organization Fibronectin matrix formation 4 genes	Col1a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000001506 Description: collagen%2C type I%2C alpha 1 [Source:MGI Symbol;Acc:MGI:88467] Location: 11:94827050-94843868 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stellate cell pericyte stromal cell stem cell valve interstitial cell mesenchymal cell endothelial cell Other: ECM proteoglycans Platelet Adhesion to exposed collagen Adaptive Immune System Col1a2 Gene Information Basic Information Ensembl ID: ENSMUSG00000029661 Description: collagen%2C type I%2C alpha 2 [Source:MGI Symbol;Acc:MGI:88468] Location: 6:4504814-4541544 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stellate cell pericyte stem cell stromal cell epithelial cell vascular cell meningeal cell Other: Adaptive Immune System Degradation of the extracellular matrix Collagen formation Col5a2 Gene Information Basic Information Ensembl ID: ENSMUSG00000026042 Description: collagen%2C type V%2C alpha 2 [Source:MGI Symbol;Acc:MGI:88458] Location: 1:45413481-45542442 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast pericyte stellate cell stromal cell mesenchymal cell Other: Degradation of the extracellular matrix Collagen formation Fibronectin matrix formation Itga5 Gene Information Basic Information Ensembl ID: ENSMUSG00000000555 Description: integrin alpha 5 (fibronectin receptor alpha) [Source:MGI Symbol;Acc:MGI:96604] Location: 15:103252713-103275190 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Elastic fibre formation Fibronectin matrix formation Cell surface interactions at the vascular wall
Formation of Fibrin Clot (Clotting Cascade) Pathway Hierarchies & Genes Common Pathway of Fibrin Clot Formation (1 genes) Hemostasis Formation of Fibrin Clot (Clotting Cascade) Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation 1 genes Common Pathway of Fibrin Clot Formation (2 genes) Hemostasis Formation of Fibrin Clot (Clotting Cascade) Common Pathway of Fibrin Clot Formation 2 genes	F13a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000039109 Description: coagulation factor XIII%2C A1 subunit [Source:MGI Symbol;Acc:MGI:1921395] Location: 13:37051152-37234220 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: hematopoietic stem cell phagocyte monocyte erythroid lineage cell T cell macrophage Other: Formation of Fibrin Clot (Clotting Cascade) Platelet activation, signaling and aggregation F2r Gene Information Basic Information Ensembl ID: ENSMUSG00000048376 Description: coagulation factor II thrombin receptor [Source:MGI Symbol;Acc:MGI:101802] Location: 13:95738311-95754995 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell fibroblast cardiomyocyte endocardial cell megakaryocyte Other: Formation of Fibrin Clot (Clotting Cascade) Signaling by GPCR Platelet activation, signaling and aggregation Serpine2 Gene Information Basic Information Ensembl ID: ENSMUSG00000026249 Description: serine (or cysteine) peptidase inhibitor%2C clade E%2C member 2 [Source:MGI Symbol;Acc:MGI:101780] Location: 1:79771914-79838897 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast pericyte glial cell stromal cell smooth muscle cell epithelial cell oligodendrocyte precursor cell schwann cell Other: Formation of Fibrin Clot (Clotting Cascade) Dissolution of Fibrin Clot
Gene Silencing by RNA Pathway Hierarchies & Genes Small interfering RNA (siRNA) biogenesis (1 genes) Gene expression (Transcription) Gene Silencing by RNA Small interfering RNA (siRNA) biogenesis 1 genes Transcriptional regulation by small RNAs (1 genes) Gene expression (Transcription) Gene Silencing by RNA Transcriptional regulation by small RNAs 1 genes	Nup85 Gene Information Basic Information Ensembl ID: ENSMUSG00000020739 Description: nucleoporin 85 [Source:MGI Symbol;Acc:MGI:3046173] Location: 11:115455260-115474811 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: bone cell Other: Metabolism of non-coding RNA Gene Silencing by RNA Cellular responses to stress Tsnax Gene Information Basic Information Ensembl ID: ENSMUSG00000056820 Description: translin-associated factor X [Source:MGI Symbol;Acc:MGI:1855672] Location: 8:125739736-125760931 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Gene Silencing by RNA
Innate Immune System Pathway Hierarchies & Genes CLEC7A (Dectin-1) signaling (3 genes) Immune System Innate Immune System Cytosolic sensors of pathogen-associated DNA ZBP1(DAI) mediated induction of type I IFNs RIP-mediated NFkB activation via ZBP1 Toll-like Receptor Cascades 2 genes Toll Like Receptor 4 (TLR4) Cascade MyD88-independent TLR4 cascade TRIF (TICAM1)-mediated TLR4 signaling DDX58/IFIH1-mediated induction of interferon-alpha/beta TRAF6 mediated NF-kB activation Fc epsilon receptor (FCERI) signaling FCERI mediated NF-kB activation C-type lectin receptors (CLRs) CLEC7A (Dectin-1) signaling 1 genes Alpha-protein kinase 1 signaling pathway (1 genes) Immune System Innate Immune System Toll-like Receptor Cascades Toll Like Receptor 4 (TLR4) Cascade MyD88-independent TLR4 cascade TRIF (TICAM1)-mediated TLR4 signaling IKK complex recruitment mediated by RIP1 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway Fc epsilon receptor (FCERI) signaling FCERI mediated NF-kB activation C-type lectin receptors (CLRs) CLEC7A (Dectin-1) signaling Alpha-protein kinase 1 signaling pathway 1 genes Alpha-protein kinase 1 signaling pathway (1 genes) Immune System Innate Immune System Toll-like Receptor Cascades Toll Like Receptor 4 (TLR4) Cascade MyD88-independent TLR4 cascade TRIF (TICAM1)-mediated TLR4 signaling TRAF6-mediated induction of TAK1 complex within TLR4 complex Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway Fc epsilon receptor (FCERI) signaling FCERI mediated NF-kB activation C-type lectin receptors (CLRs) CLEC7A (Dectin-1) signaling Alpha-protein kinase 1 signaling pathway 1 genes CLEC7A/inflammasome pathway (3 genes) Immune System Innate Immune System Toll-like Receptor Cascades Toll Like Receptor 4 (TLR4) Cascade MyD88-independent TLR4 cascade TRIF (TICAM1)-mediated TLR4 signaling TRIF-mediated programmed cell death 2 genes Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway C-type lectin receptors (CLRs) CLEC7A (Dectin-1) signaling CLEC7A/inflammasome pathway 1 genes Dectin-2 family (6 genes) Immune System Innate Immune System Fcgamma receptor (FCGR) dependent phagocytosis FCGR activation 2 genes DAP12 interactions 1 genes DAP12 signaling Fc epsilon receptor (FCERI) signaling Role of LAT2/NTAL/LAB on calcium mobilization 2 genes C-type lectin receptors (CLRs) Dectin-2 family 1 genes FCERI mediated MAPK activation (1 genes) Immune System Innate Immune System Toll-like Receptor Cascades Toll Like Receptor 3 (TLR3) Cascade MAP kinase activation MAPK targets/ Nuclear events mediated by MAP kinases Activation of the AP-1 family of transcription factors Fc epsilon receptor (FCERI) signaling FCERI mediated MAPK activation 1 genes Neutrophil degranulation (4 genes) Immune System Innate Immune System Toll-like Receptor Cascades Toll Like Receptor 4 (TLR4) Cascade MyD88-independent TLR4 cascade TRIF (TICAM1)-mediated TLR4 signaling Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 3 genes Neutrophil degranulation 1 genes Neutrophil degranulation (2 genes) Immune System Innate Immune System Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Inflammasomes The NLRP3 inflammasome 1 genes C-type lectin receptors (CLRs) CLEC7A (Dectin-1) signaling CLEC7A/inflammasome pathway Neutrophil degranulation 1 genes CD209 (DC-SIGN) signaling (7 genes) Immune System Innate Immune System Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation 5 genes Fc epsilon receptor (FCERI) signaling FCERI mediated MAPK activation C-type lectin receptors (CLRs) CD209 (DC-SIGN) signaling 2 genes FCERI mediated MAPK activation (2 genes) Immune System Innate Immune System Fcgamma receptor (FCGR) dependent phagocytosis Role of phospholipids in phagocytosis 1 genes DAP12 interactions DAP12 signaling Fc epsilon receptor (FCERI) signaling FCERI mediated MAPK activation 1 genes NOD1/2 Signaling Pathway (2 genes) Immune System Innate Immune System Toll-like Receptor Cascades Toll Like Receptor 3 (TLR3) Cascade MAP kinase activation activated TAK1 mediates p38 MAPK activation Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway 2 genes Neutrophil degranulation (1 genes) Immune System Innate Immune System Antimicrobial peptides Defensins Beta defensins Toll-like Receptor Cascades Regulation of TLR by endogenous ligand Neutrophil degranulation 1 genes Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (1 genes) Immune System Innate Immune System Toll-like Receptor Cascades Toll Like Receptor 4 (TLR4) Cascade MyD88-independent TLR4 cascade TRIF (TICAM1)-mediated TLR4 signaling Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 1 genes IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (1 genes) Immune System Innate Immune System Toll-like Receptor Cascades Toll Like Receptor 9 (TLR9) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 1 genes Ion influx/efflux at host-pathogen interface (6 genes) Immune System Innate Immune System ROS and RNS production in phagocytes 4 genes Neutrophil degranulation 1 genes Antimicrobial peptides Ion influx/efflux at host-pathogen interface 1 genes MAPK targets/ Nuclear events mediated by MAP kinases (2 genes) Immune System Innate Immune System Toll-like Receptor Cascades Toll Like Receptor 3 (TLR3) Cascade MAP kinase activation MAPK targets/ Nuclear events mediated by MAP kinases 2 genes Neutrophil degranulation (1 genes) Immune System Innate Immune System Cytosolic sensors of pathogen-associated DNA STING mediated induction of host immune responses STAT6-mediated induction of chemokines Neutrophil degranulation 1 genes Role of LAT2/NTAL/LAB on calcium mobilization (2 genes) Immune System Innate Immune System DAP12 interactions DAP12 signaling Fc epsilon receptor (FCERI) signaling Role of LAT2/NTAL/LAB on calcium mobilization 2 genes CLEC7A/inflammasome pathway (1 genes) Immune System Innate Immune System C-type lectin receptors (CLRs) CLEC7A (Dectin-1) signaling CLEC7A/inflammasome pathway 1 genes Neutrophil degranulation (3 genes) Immune System Innate Immune System Toll-like Receptor Cascades Toll Like Receptor 4 (TLR4) Cascade 1 genes Neutrophil degranulation 2 genes Neutrophil degranulation (1 genes) Immune System Innate Immune System ROS and RNS production in phagocytes Events associated with phagocytolytic activity of PMN cells Neutrophil degranulation 1 genes RIP-mediated NFkB activation via ZBP1 (1 genes) Immune System Innate Immune System Cytosolic sensors of pathogen-associated DNA ZBP1(DAI) mediated induction of type I IFNs RIP-mediated NFkB activation via ZBP1 1 genes The NLRP1 inflammasome (1 genes) Immune System Innate Immune System Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Inflammasomes The NLRP1 inflammasome 1 genes Dectin-2 family (1 genes) Immune System Innate Immune System C-type lectin receptors (CLRs) Dectin-2 family 1 genes FCERI mediated Ca+2 mobilization (1 genes) Immune System Innate Immune System Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization 1 genes LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production (1 genes) Immune System Innate Immune System Cytosolic sensors of pathogen-associated DNA LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 1 genes NOD1/2 Signaling Pathway (2 genes) Immune System Innate Immune System Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway 2 genes Regulation of innate immune responses to cytosolic DNA (2 genes) Immune System Innate Immune System Cytosolic sensors of pathogen-associated DNA Regulation of innate immune responses to cytosolic DNA 2 genes Role of LAT2/NTAL/LAB on calcium mobilization (1 genes) Immune System Innate Immune System Fc epsilon receptor (FCERI) signaling Role of LAT2/NTAL/LAB on calcium mobilization 1 genes Terminal pathway of complement (3 genes) Immune System Innate Immune System Complement cascade Terminal pathway of complement 3 genes Trafficking and processing of endosomal TLR (1 genes) Immune System Innate Immune System Toll-like Receptor Cascades Trafficking and processing of endosomal TLR 1 genes Antimicrobial peptides (1 genes) Immune System Innate Immune System Antimicrobial peptides 1 genes DAP12 interactions (1 genes) Immune System Innate Immune System DAP12 interactions 1 genes Neutrophil degranulation (40 genes) Immune System Innate Immune System Neutrophil degranulation 40 genes	Abl1 Gene Information Basic Information Ensembl ID: ENSMUSG00000026842 Description: c-abl oncogene 1%2C non-receptor tyrosine kinase [Source:MGI Symbol;Acc:MGI:87859] Location: 2:31578388-31694239 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Epigenetic regulation of gene expression Myogenesis Adam8 Gene Information Basic Information Ensembl ID: ENSMUSG00000025473 Description: a disintegrin and metallopeptidase domain 8 [Source:MGI Symbol;Acc:MGI:107825] Location: 7:139558845-139572475 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell phagocyte dendritic cell granulocyte neutrophil Other: Degradation of the extracellular matrix Innate Immune System Adgre5 Gene Information Basic Information Ensembl ID: ENSMUSG00000002885 Description: adhesion G protein-coupled receptor E5 [Source:MGI Symbol;Acc:MGI:1347095] Location: 8:84449880-84467955 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell endothelial cell monocyte Other: Innate Immune System Signaling by GPCR Adgrg3 Gene Information Basic Information Ensembl ID: ENSMUSG00000060470 Description: adhesion G protein-coupled receptor G3 [Source:MGI Symbol;Acc:MGI:1859670] Location: 8:95744320-95771878 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell endothelial cell eosinophil Other: Innate Immune System Ano6 Gene Information Basic Information Ensembl ID: ENSMUSG00000064210 Description: anoctamin 6 [Source:MGI Symbol;Acc:MGI:2145890] Location: 15:95688724-95872632 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell Other: Innate Immune System Ion channel transport Anxa2 Gene Information Basic Information Ensembl ID: ENSMUSG00000032231 Description: annexin A2 [Source:MGI Symbol;Acc:MGI:88246] Location: 9:69360902-69399077 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell endothelial cell natural killer cell stem cell epithelial cell monocyte Other: Innate Immune System Dissolution of Fibrin Clot Cellular responses to mechanical stimuli Bcl2 Gene Information Basic Information Ensembl ID: ENSMUSG00000057329 Description: B cell leukemia/lymphoma 2 [Source:MGI Symbol;Acc:MGI:88138] Location: 1:106465908-106642004 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Apoptosis Innate Immune System Btk Gene Information Basic Information Ensembl ID: ENSMUSG00000031264 Description: Bruton agammaglobulinemia tyrosine kinase [Source:MGI Symbol;Acc:MGI:88216] Location: X:133443085-133484319 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Naive B cell Other: Adaptive Immune System Innate Immune System Signaling by GPCR C6 Gene Information Basic Information Ensembl ID: ENSMUSG00000022181 Description: complement component 6 [Source:MGI Symbol;Acc:MGI:88233] Location: 15:4756657-4844449 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: antigen presenting cell Other: Innate Immune System C8a Gene Information Basic Information Ensembl ID: ENSMUSG00000035031 Description: complement component 8%2C alpha polypeptide [Source:MGI Symbol;Acc:MGI:2668347] Location: 4:104672876-104733595 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: hepatocyte Other: Innate Immune System Casp1 Gene Information Basic Information Ensembl ID: ENSMUSG00000025888 Description: caspase 1 [Source:MGI Symbol;Acc:MGI:96544] Location: 9:5298508-5307290 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Innate Immune System Regulated Necrosis Casp4 Gene Information Basic Information Ensembl ID: ENSMUSG00000033538 Description: caspase 4%2C apoptosis-related cysteine peptidase [Source:MGI Symbol;Acc:MGI:107700] Location: 9:5308828-5336783 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Regulated Necrosis Casp8 Gene Information Basic Information Ensembl ID: ENSMUSG00000026029 Description: caspase 8 [Source:MGI Symbol;Acc:MGI:1261423] Location: 1:58834533-58886662 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System Cd247 Gene Information Basic Information Ensembl ID: ENSMUSG00000005763 Description: CD247 antigen [Source:MGI Symbol;Acc:MGI:88334] Location: 1:165616250-165704846 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell developing T cell CD4+ T cell T cell hematopoietic cell Other: Adaptive Immune System Innate Immune System Cd44 Gene Information Basic Information Ensembl ID: ENSMUSG00000005087 Description: CD44 antigen [Source:MGI Symbol;Acc:MGI:88338] Location: 2:102641486-102732010 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell phagocyte monocyte granulocyte neutrophil macrophage progenitor cell Other: Cell surface interactions at the vascular wall Integrin cell surface interactions Innate Immune System Cd53 Gene Information Basic Information Ensembl ID: ENSMUSG00000040747 Description: CD53 antigen [Source:MGI Symbol;Acc:MGI:88341] Location: 3:106667237-106697465 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell dendritic cell developing T cell phagocyte CD4+ T cell leukocyte mast cell erythroid progenitor cell T cell monocyte lymphocyte macrophage myeloid cell Other: Innate Immune System Cd93 Gene Information Basic Information Ensembl ID: ENSMUSG00000027435 Description: CD93 antigen [Source:MGI Symbol;Acc:MGI:106664] Location: 2:148278560-148285483 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Innate Immune System Cdc42 Gene Information Basic Information Ensembl ID: ENSMUSG00000006699 Description: cell division cycle 42 [Source:MGI Symbol;Acc:MGI:106211] Location: 4:137047007-137085031 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: hematopoietic stem cell phagocyte antigen presenting cell macrophage dendritic cell Other: Adaptive Immune System Innate Immune System Signaling by GPCR Ckap4 Gene Information Basic Information Ensembl ID: ENSMUSG00000046841 Description: cytoskeleton-associated protein 4 [Source:MGI Symbol;Acc:MGI:2444926] Location: 10:84362169-84369926 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell fibroblast smooth muscle cell granulocyte epithelial cell osteoblast Other: Innate Immune System Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Surfactant metabolism Clec4e Gene Information Basic Information Ensembl ID: ENSMUSG00000030142 Description: C-type lectin domain family 4%2C member e [Source:MGI Symbol;Acc:MGI:1861232] Location: 6:123258748-123266829 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell granulocyte monocyte erythroblast Other: Innate Immune System Cpne1 Gene Information Basic Information Ensembl ID: ENSMUSG00000074643 Description: copine I [Source:MGI Symbol;Acc:MGI:2386621] Location: 2:155913762-155953885 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Metabolism of lipids Creb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000025958 Description: cAMP responsive element binding protein 1 [Source:MGI Symbol;Acc:MGI:88494] Location: 1:64571804-64643707 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Transmission across Chemical Synapses Cytokine Signaling in Immune system Innate Immune System Ctnnb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000006932 Description: catenin beta 1 [Source:MGI Symbol;Acc:MGI:88276] Location: 9:120758282-120789573 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stem cell epithelial cell Other: Apoptosis Innate Immune System Signaling by WNT Ctsh Gene Information Basic Information Ensembl ID: ENSMUSG00000032359 Description: cathepsin H [Source:MGI Symbol;Acc:MGI:107285] Location: 9:89936205-89958142 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte pneumocyte monocyte T cell myeloid progenitor cell Other: Adaptive Immune System Innate Immune System Surfactant metabolism Cybb Gene Information Basic Information Ensembl ID: ENSMUSG00000015340 Description: cytochrome b-245%2C beta polypeptide [Source:MGI Symbol;Acc:MGI:88574] Location: X:9301491-9354010 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: monocyte Other: Adaptive Immune System Innate Immune System Cellular responses to stress Cyfip2 Gene Information Basic Information Ensembl ID: ENSMUSG00000020340 Description: cytoplasmic FMR1 interacting protein 2 [Source:MGI Symbol;Acc:MGI:1924134] Location: 11:46084677-46203686 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell neuron developing T cell Naive B cell Specialized T cell Other: Signaling by Receptor Tyrosine Kinases Innate Immune System Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Dera Gene Information Basic Information Ensembl ID: ENSMUSG00000030225 Description: deoxyribose-phosphate aldolase [Source:MGI Symbol;Acc:MGI:1913762] Location: 6:137731544-137834338 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Metabolism of carbohydrates and carbohydrate derivatives Dgat1 Gene Information Basic Information Ensembl ID: ENSMUSG00000022555 Description: diacylglycerol O-acyltransferase 1 [Source:MGI Symbol;Acc:MGI:1333825] Location: 15:76386215-76396153 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell developing T cell epithelial cell adipocyte hematopoietic stem cell mast cell Other: Innate Immune System Metabolism of lipids Dnm3 Gene Information Basic Information Ensembl ID: ENSMUSG00000040265 Description: dynamin 3 [Source:MGI Symbol;Acc:MGI:1341299] Location: 1:161810022-162305603 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Adaptive Immune System Innate Immune System Membrane Trafficking Dsp Gene Information Basic Information Ensembl ID: ENSMUSG00000054889 Description: desmoplakin [Source:MGI Symbol;Acc:MGI:109611] Location: 13:38335270-38382553 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell tuft cell skeletal muscle cell basal cell Other: Apoptosis Innate Immune System Keratinization Fadd Gene Information Basic Information Ensembl ID: ENSMUSG00000031077 Description: Fas associated via death domain [Source:MGI Symbol;Acc:MGI:109324] Location: 7:144131055-144136200 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Apoptosis Innate Immune System Regulated Necrosis Fcgr1 Gene Information Basic Information Ensembl ID: ENSMUSG00000015947 Description: Fc receptor%2C IgG%2C high affinity I [Source:MGI Symbol;Acc:MGI:95498] Location: 3:96190225-96201285 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte antigen presenting cell macrophage dendritic cell monocyte hematopoietic cell neutrophil Other: Adaptive Immune System Innate Immune System Fgr Gene Information Basic Information Ensembl ID: ENSMUSG00000028874 Description: FGR proto-oncogene%2C Src family tyrosine kinase [Source:MGI Symbol;Acc:MGI:95527] Location: 4:132701406-132729221 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Platelet homeostasis Fpr1 Gene Information Basic Information Ensembl ID: ENSMUSG00000045551 Description: formyl peptide receptor 1 [Source:MGI Symbol;Acc:MGI:107443] Location: 17:18096733-18104202 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell mast cell neutrophil Other: Innate Immune System Signaling by GPCR Fyn Gene Information Basic Information Ensembl ID: ENSMUSG00000019843 Description: Fyn proto-oncogene [Source:MGI Symbol;Acc:MGI:95602] Location: 10:39244851-39441377 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cell surface interactions at the vascular wall Nephrin family interactions Cytokine Signaling in Immune system Gm2a Gene Information Basic Information Ensembl ID: ENSMUSG00000000594 Description: GM2 ganglioside activator protein [Source:MGI Symbol;Acc:MGI:95762] Location: 11:54988941-55003855 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Metabolism of lipids Hc Gene Information Basic Information Ensembl ID: ENSMUSG00000026874 Description: hemolytic complement [Source:MGI Symbol;Acc:MGI:96031] Location: 2:34873343-34951450 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pneumocyte Other: Innate Immune System Signaling by GPCR Il1b Gene Information Basic Information Ensembl ID: ENSMUSG00000027398 Description: interleukin 1 beta [Source:MGI Symbol;Acc:MGI:96543] Location: 2:129206490-129213059 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell dendritic cell phagocyte granulocyte myeloid cell erythroid lineage cell T cell leukocyte macrophage Other: Cytokine Signaling in Immune system Innate Immune System Regulated Necrosis Ilf2 Gene Information Basic Information Ensembl ID: ENSMUSG00000001016 Description: interleukin enhancer binding factor 2 [Source:MGI Symbol;Acc:MGI:1915031] Location: 3:90383433-90395686 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stem cell Other: Cytokine Signaling in Immune system Innate Immune System Iqgap1 Gene Information Basic Information Ensembl ID: ENSMUSG00000030536 Description: IQ motif containing GTPase activating protein 1 [Source:MGI Symbol;Acc:MGI:1352757] Location: 7:80361331-80475722 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell phagocyte epithelial cell macrophage monocyte granulocyte neutrophil Other: Innate Immune System Nephrin family interactions MAPK family signaling cascades Irak1 Gene Information Basic Information Ensembl ID: ENSMUSG00000031392 Description: interleukin-1 receptor-associated kinase 1 [Source:MGI Symbol;Acc:MGI:107420] Location: X:73057520-73067524 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Innate Immune System Death Receptor Signaling Itgal Gene Information Basic Information Ensembl ID: ENSMUSG00000030830 Description: integrin alpha L [Source:MGI Symbol;Acc:MGI:96606] Location: 7:126895432-126934310 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell CD4+ T cell CD8+ T cell monocyte Specialized T cell Other: Adaptive Immune System Innate Immune System Cell surface interactions at the vascular wall Itgam Gene Information Basic Information Ensembl ID: ENSMUSG00000030786 Description: integrin alpha M [Source:MGI Symbol;Acc:MGI:96607] Location: 7:127661812-127717663 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell phagocyte macrophage monocyte myeloid cell dendritic cell microglia myeloid derived suppressor cell immune cell Other: Innate Immune System Cell surface interactions at the vascular wall Integrin cell surface interactions Itgav Gene Information Basic Information Ensembl ID: ENSMUSG00000027087 Description: integrin alpha V [Source:MGI Symbol;Acc:MGI:96608] Location: 2:83554741-83637260 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell bone cell Other: ECM proteoglycans Non-integrin membrane-ECM interactions Adaptive Immune System Itgax Gene Information Basic Information Ensembl ID: ENSMUSG00000030789 Description: integrin alpha X [Source:MGI Symbol;Acc:MGI:96609] Location: 7:127728719-127749829 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell phagocyte macrophage dendritic cell Other: Innate Immune System Cell surface interactions at the vascular wall Integrin cell surface interactions Itgb2 Gene Information Basic Information Ensembl ID: ENSMUSG00000000290 Description: integrin beta 2 [Source:MGI Symbol;Acc:MGI:96611] Location: 10:77366086-77401542 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell monocyte neutrophil Other: Adaptive Immune System Innate Immune System Cell surface interactions at the vascular wall Jup Gene Information Basic Information Ensembl ID: ENSMUSG00000001552 Description: junction plakoglobin [Source:MGI Symbol;Acc:MGI:96650] Location: 11:100259784-100288589 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stellate cell stem cell epithelial cell smooth muscle cell keratinocyte basal cell Other: Innate Immune System Cell junction organization Keratinization Lat2 Gene Information Basic Information Ensembl ID: ENSMUSG00000040751 Description: linker for activation of T cells family%2C member 2 [Source:MGI Symbol;Acc:MGI:1926479] Location: 5:134628876-134643879 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell phagocyte mast cell eosinophil Other: Innate Immune System Lilra5 Gene Information Basic Information Ensembl ID: ENSMUSG00000070873 Description: leukocyte immunoglobulin-like receptor%2C subfamily A (with TM domain)%2C member 5 [Source:MGI Symbol;Acc:MGI:3647196] Location: 7:4240753-4246462 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte Other: Innate Immune System Lpcat1 Gene Information Basic Information Ensembl ID: ENSMUSG00000021608 Description: lysophosphatidylcholine acyltransferase 1 [Source:MGI Symbol;Acc:MGI:2384812] Location: 13:73615316-73664541 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pneumocyte Other: Innate Immune System Metabolism of lipids Lyn Gene Information Basic Information Ensembl ID: ENSMUSG00000042228 Description: LYN proto-oncogene%2C Src family tyrosine kinase [Source:MGI Symbol;Acc:MGI:96892] Location: 4:3678115-3813122 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Platelet Adhesion to exposed collagen Cytokine Signaling in Immune system Adaptive Immune System Map2k6 Gene Information Basic Information Ensembl ID: ENSMUSG00000020623 Description: mitogen-activated protein kinase kinase 6 [Source:MGI Symbol;Acc:MGI:1346870] Location: 11:110289948-110416348 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: bergmann glial cell skeletal muscle cell Other: Cytokine Signaling in Immune system Innate Immune System Cellular responses to stress Map3k7 Gene Information Basic Information Ensembl ID: ENSMUSG00000028284 Description: mitogen-activated protein kinase kinase kinase 7 [Source:MGI Symbol;Acc:MGI:1346877] Location: 4:31964097-32023467 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Mapk8 Gene Information Basic Information Ensembl ID: ENSMUSG00000021936 Description: mitogen-activated protein kinase 8 [Source:MGI Symbol;Acc:MGI:1346861] Location: 14:33099855-33169115 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System Mmp8 Gene Information Basic Information Ensembl ID: ENSMUSG00000005800 Description: matrix metallopeptidase 8 [Source:MGI Symbol;Acc:MGI:1202395] Location: 9:7558457-7568486 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell granulocyte monocyte Other: Degradation of the extracellular matrix Innate Immune System Mpo Gene Information Basic Information Ensembl ID: ENSMUSG00000009350 Description: myeloperoxidase [Source:MGI Symbol;Acc:MGI:97137] Location: 11:87684407-87695239 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: myeloid cell Other: Innate Immune System Myd88 Gene Information Basic Information Ensembl ID: ENSMUSG00000032508 Description: myeloid differentiation primary response gene 88 [Source:MGI Symbol;Acc:MGI:108005] Location: 9:119165000-119170477 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Innate Immune System Death Receptor Signaling Myh9 Gene Information Basic Information Ensembl ID: ENSMUSG00000022443 Description: myosin%2C heavy polypeptide 9%2C non-muscle [Source:MGI Symbol;Acc:MGI:107717] Location: 15:77644787-77726375 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell stromal cell Other: Innate Immune System Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Myo5a Gene Information Basic Information Ensembl ID: ENSMUSG00000034593 Description: myosin VA [Source:MGI Symbol;Acc:MGI:105976] Location: 9:74978297-75130970 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte antigen presenting cell Other: Innate Immune System MITF-M-regulated melanocyte development Ncf1 Gene Information Basic Information Ensembl ID: ENSMUSG00000015950 Description: neutrophil cytosolic factor 1 [Source:MGI Symbol;Acc:MGI:97283] Location: 5:134248907-134258479 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell hematopoietic stem cell phagocyte granulocyte Other: Adaptive Immune System Innate Immune System Cellular responses to stress Ncf4 Gene Information Basic Information Ensembl ID: ENSMUSG00000071715 Description: neutrophil cytosolic factor 4 [Source:MGI Symbol;Acc:MGI:109186] Location: 15:78129001-78146780 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell dendritic cell erythrocyte granulocyte monocyte Other: Adaptive Immune System Innate Immune System Cellular responses to stress Nfasc Gene Information Basic Information Ensembl ID: ENSMUSG00000026442 Description: neurofascin [Source:MGI Symbol;Acc:MGI:104753] Location: 1:132492428-132669535 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron bipolar cell astrocyte Other: Innate Immune System Nervous system development Nos2 Gene Information Basic Information Ensembl ID: ENSMUSG00000020826 Description: nitric oxide synthase 2%2C inducible [Source:MGI Symbol;Acc:MGI:97361] Location: 11:78811613-78851080 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: macrophage Other: Innate Immune System Platelet homeostasis Peroxisomal protein import P2rx7 Gene Information Basic Information Ensembl ID: ENSMUSG00000029468 Description: purinergic receptor P2X%2C ligand-gated ion channel%2C 7 [Source:MGI Symbol;Acc:MGI:1339957] Location: 5:122781974-122829495 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Platelet homeostasis Pak1 Gene Information Basic Information Ensembl ID: ENSMUSG00000030774 Description: p21 (RAC1) activated kinase 1 [Source:MGI Symbol;Acc:MGI:1339975] Location: 7:97437748-97561588 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell epithelial cell excitatory neuron Other: Adaptive Immune System Innate Immune System Signaling by GPCR Pdxk Gene Information Basic Information Ensembl ID: ENSMUSG00000032788 Description: pyridoxal (pyridoxine%2C vitamin B6) kinase [Source:MGI Symbol;Acc:MGI:1351869] Location: 10:78272578-78300809 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Metabolism of vitamins and cofactors Pecam1 Gene Information Basic Information Ensembl ID: ENSMUSG00000020717 Description: platelet/endothelial cell adhesion molecule 1 [Source:MGI Symbol;Acc:MGI:97537] Location: 11:106545043-106641454 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell epithelial cell Other: Innate Immune System Cell surface interactions at the vascular wall Integrin cell surface interactions Pglyrp2 Gene Information Basic Information Ensembl ID: ENSMUSG00000079563 Description: peptidoglycan recognition protein 2 [Source:MGI Symbol;Acc:MGI:1928099] Location: 17:32631433-32643141 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Pla2g6 Gene Information Basic Information Ensembl ID: ENSMUSG00000042632 Description: phospholipase A2%2C group VI [Source:MGI Symbol;Acc:MGI:1859152] Location: 15:79170428-79212590 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Membrane Trafficking Metabolism of lipids Plcg1 Gene Information Basic Information Ensembl ID: ENSMUSG00000016933 Description: phospholipase C%2C gamma 1 [Source:MGI Symbol;Acc:MGI:97615] Location: 2:160573220-160617680 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Inositol phosphate metabolism Ppp2ca Gene Information Basic Information Ensembl ID: ENSMUSG00000020349 Description: protein phosphatase 2 (formerly 2A)%2C catalytic subunit%2C alpha isoform [Source:MGI Symbol;Acc:MGI:1321159] Location: 11:51989508-52018605 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Psen1 Gene Information Basic Information Ensembl ID: ENSMUSG00000019969 Description: presenilin 1 [Source:MGI Symbol;Acc:MGI:1202717] Location: 12:83734926-83781973 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Signaling by NOTCH Death Receptor Signaling Ptafr Gene Information Basic Information Ensembl ID: ENSMUSG00000056529 Description: platelet-activating factor receptor [Source:MGI Symbol;Acc:MGI:106066] Location: 4:132291378-132309994 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell granulocyte T cell Other: Innate Immune System Signaling by GPCR Ptpn11 Gene Information Basic Information Ensembl ID: ENSMUSG00000043733 Description: protein tyrosine phosphatase%2C non-receptor type 11 [Source:MGI Symbol;Acc:MGI:99511] Location: 5:121268596-121329460 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Nervous system development Cytokine Signaling in Immune system Adaptive Immune System Ptpn6 Gene Information Basic Information Ensembl ID: ENSMUSG00000004266 Description: protein tyrosine phosphatase%2C non-receptor type 6 [Source:MGI Symbol;Acc:MGI:96055] Location: 6:124697670-124715677 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell Naive B cell tuft cell monocyte dendritic cell macrophage Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Pycard Gene Information Basic Information Ensembl ID: ENSMUSG00000030793 Description: PYD and CARD domain containing [Source:MGI Symbol;Acc:MGI:1931465] Location: 7:127588880-127593039 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Qpct Gene Information Basic Information Ensembl ID: ENSMUSG00000024084 Description: glutaminyl-peptide cyclotransferase (glutaminyl cyclase) [Source:MGI Symbol;Acc:MGI:1917786] Location: 17:79359335-79397807 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron oligodendrocyte precursor cell dendritic cell Other: Innate Immune System Rab44 Gene Information Basic Information Ensembl ID: ENSMUSG00000064147 Description: RAB44%2C member RAS oncogene family [Source:MGI Symbol;Acc:MGI:3045302] Location: 17:29333119-29367954 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell mast cell granulocyte basophil eosinophil Other: Innate Immune System Post-translational protein modification Rac2 Gene Information Basic Information Ensembl ID: ENSMUSG00000033220 Description: Rac family small GTPase 2 [Source:MGI Symbol;Acc:MGI:97846] Location: 15:78443367-78456983 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell dendritic cell developing T cell tuft cell CD4+ T cell mast cell T cell granulocyte leukocyte lymphocyte Other: Innate Immune System Signaling by WNT Platelet activation, signaling and aggregation Rela Gene Information Basic Information Ensembl ID: ENSMUSG00000024927 Description: v-rel reticuloendotheliosis viral oncogene homolog A (avian) [Source:MGI Symbol;Acc:MGI:103290] Location: 19:5687511-5698158 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Ripk1 Gene Information Basic Information Ensembl ID: ENSMUSG00000021408 Description: receptor (TNFRSF)-interacting serine-threonine kinase 1 [Source:MGI Symbol;Acc:MGI:108212] Location: 13:34186346-34221130 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Apoptosis Innate Immune System Regulated Necrosis Ripk2 Gene Information Basic Information Ensembl ID: ENSMUSG00000041135 Description: receptor (TNFRSF)-interacting serine-threonine kinase 2 [Source:MGI Symbol;Acc:MGI:1891456] Location: 4:16122733-16163647 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Serpinb1a Gene Information Basic Information Ensembl ID: ENSMUSG00000044734 Description: serine (or cysteine) peptidase inhibitor%2C clade B%2C member 1a [Source:MGI Symbol;Acc:MGI:1913472] Location: 13:33026075-33035168 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell Naive B cell CD4+ T cell fibroblast tuft cell bone cell mast cell granulocyte basophil Other: Innate Immune System Shc1 Gene Information Basic Information Ensembl ID: ENSMUSG00000042626 Description: src homology 2 domain-containing transforming protein C1 [Source:MGI Symbol;Acc:MGI:98296] Location: 3:89325750-89337334 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Innate Immune System Cell surface interactions at the vascular wall Siglece Gene Information Basic Information Ensembl ID: ENSMUSG00000030474 Description: sialic acid binding Ig-like lectin E [Source:MGI Symbol;Acc:MGI:1932475] Location: 7:43300494-43309585 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell neutrophil Other: Adaptive Immune System Innate Immune System Slc11a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000026177 Description: solute carrier family 11 (proton-coupled divalent metal ion transporters)%2C member 1 [Source:MGI Symbol;Acc:MGI:1345275] Location: 1:74414354-74425221 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte monocyte myeloid cell Other: Innate Immune System SLC-mediated transmembrane transport Slc44a2 Gene Information Basic Information Ensembl ID: ENSMUSG00000057193 Description: solute carrier family 44%2C member 2 [Source:MGI Symbol;Acc:MGI:1915932] Location: 9:21231994-21266324 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System SLC-mediated transmembrane transport Metabolism of lipids Sos1 Gene Information Basic Information Ensembl ID: ENSMUSG00000024241 Description: SOS Ras/Rac guanine nucleotide exchange factor 1 [Source:MGI Symbol;Acc:MGI:98354] Location: 17:80701180-80787882 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Sting1 Gene Information Basic Information Ensembl ID: ENSMUSG00000024349 Description: stimulator of interferon response cGAMP interactor 1 [Source:MGI Symbol;Acc:MGI:1919762] Location: 18:35866732-35873607 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Syk Gene Information Basic Information Ensembl ID: ENSMUSG00000021457 Description: spleen tyrosine kinase [Source:MGI Symbol;Acc:MGI:99515] Location: 13:52737209-52802828 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell Naive B cell monocyte granulocyte Other: Integrin signaling Cytokine Signaling in Immune system Adaptive Immune System Ticam1 Gene Information Basic Information Ensembl ID: ENSMUSG00000047123 Description: TIR domain containing adaptor molecule 1 [Source:MGI Symbol;Acc:MGI:2147032] Location: 17:56576319-56583786 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Apoptosis Innate Immune System Ticam2 Gene Information Basic Information Ensembl ID: ENSMUSG00000056130 Description: TIR domain containing adaptor molecule 2 [Source:MGI Symbol;Acc:MGI:3040056] Location: 18:46690358-46707600 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Apoptosis Innate Immune System Tlr2 Gene Information Basic Information Ensembl ID: ENSMUSG00000027995 Description: toll-like receptor 2 [Source:MGI Symbol;Acc:MGI:1346060] Location: 3:83743579-83749074 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte leukocyte Other: Innate Immune System Tlr4 Gene Information Basic Information Ensembl ID: ENSMUSG00000039005 Description: toll-like receptor 4 [Source:MGI Symbol;Acc:MGI:96824] Location: 4:66745821-66848521 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte Other: Apoptosis Innate Immune System Cellular responses to stress Tlr9 Gene Information Basic Information Ensembl ID: ENSMUSG00000045322 Description: toll-like receptor 9 [Source:MGI Symbol;Acc:MGI:1932389] Location: 9:106099797-106104082 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Signaling by Receptor Tyrosine Kinases Tmbim1 Gene Information Basic Information Ensembl ID: ENSMUSG00000006301 Description: transmembrane BAX inhibitor motif containing 1 [Source:MGI Symbol;Acc:MGI:1916910] Location: 1:74327406-74344781 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Innate Immune System Tollip Gene Information Basic Information Ensembl ID: ENSMUSG00000025139 Description: toll interacting protein [Source:MGI Symbol;Acc:MGI:1891808] Location: 7:141428550-141472244 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Innate Immune System Traf2 Gene Information Basic Information Ensembl ID: ENSMUSG00000026942 Description: TNF receptor-associated factor 2 [Source:MGI Symbol;Acc:MGI:101835] Location: 2:25407994-25436952 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System Traf3 Gene Information Basic Information Ensembl ID: ENSMUSG00000021277 Description: TNF receptor-associated factor 3 [Source:MGI Symbol;Acc:MGI:108041] Location: 12:111132804-111233587 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Cytokine Signaling in Immune system Innate Immune System Post-translational protein modification Traf6 Gene Information Basic Information Ensembl ID: ENSMUSG00000027164 Description: TNF receptor-associated factor 6 [Source:MGI Symbol;Acc:MGI:108072] Location: 2:101508774-101532014 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Post-translational protein modification Cytokine Signaling in Immune system Adaptive Immune System Trem1 Gene Information Basic Information Ensembl ID: ENSMUSG00000042265 Description: triggering receptor expressed on myeloid cells 1 [Source:MGI Symbol;Acc:MGI:1930005] Location: 17:48539796-48553952 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell granulocyte monocyte Other: Adaptive Immune System Innate Immune System Cell surface interactions at the vascular wall Trim32 Gene Information Basic Information Ensembl ID: ENSMUSG00000051675 Description: tripartite motif-containing 32 [Source:MGI Symbol;Acc:MGI:1917057] Location: 4:65523223-65534475 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Adaptive Immune System Innate Immune System Trim56 Gene Information Basic Information Ensembl ID: ENSMUSG00000043279 Description: tripartite motif-containing 56 [Source:MGI Symbol;Acc:MGI:2685298] Location: 5:137134498-137145063 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Trpm2 Gene Information Basic Information Ensembl ID: ENSMUSG00000009292 Description: transient receptor potential cation channel%2C subfamily M%2C member 2 [Source:MGI Symbol;Acc:MGI:1351901] Location: 10:77743556-77806397 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: kupffer cell Other: Innate Immune System Ion channel transport Txk Gene Information Basic Information Ensembl ID: ENSMUSG00000054892 Description: TXK tyrosine kinase [Source:MGI Symbol;Acc:MGI:102960] Location: 5:72853321-72910120 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell developing T cell T cell Other: Innate Immune System Usp18 Gene Information Basic Information Ensembl ID: ENSMUSG00000030107 Description: ubiquitin specific peptidase 18 [Source:MGI Symbol;Acc:MGI:1344364] Location: 6:121222865-121247876 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Cytokine Signaling in Immune system Innate Immune System Post-translational protein modification Vnn1 Gene Information Basic Information Ensembl ID: ENSMUSG00000037440 Description: vanin 1 [Source:MGI Symbol;Acc:MGI:108395] Location: 10:23770586-23781241 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Metabolism of vitamins and cofactors Post-translational protein modification
Inositol phosphate metabolism Pathway Hierarchies & Genes Synthesis of IP3 and IP4 in the cytosol (1 genes) Metabolism Inositol phosphate metabolism Synthesis of IP3 and IP4 in the cytosol 1 genes	Plcg1 Gene Information Basic Information Ensembl ID: ENSMUSG00000016933 Description: phospholipase C%2C gamma 1 [Source:MGI Symbol;Acc:MGI:97615] Location: 2:160573220-160617680 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Inositol phosphate metabolism
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Pathway Hierarchies & Genes Insertion of tail-anchored proteins into the endoplasmic reticulum membrane (1 genes) Protein localization Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 1 genes	Prnp Gene Information Basic Information Ensembl ID: ENSMUSG00000079037 Description: prion protein [Source:MGI Symbol;Acc:MGI:97769] Location: 2:131751848-131780349 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Integration of energy metabolism Pathway Hierarchies & Genes Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (3 genes) Metabolism Integration of energy metabolism Regulation of insulin secretion Free fatty acids regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 3 genes Adrenaline,noradrenaline inhibits insulin secretion (3 genes) Metabolism Integration of energy metabolism Regulation of insulin secretion Adrenaline,noradrenaline inhibits insulin secretion 3 genes Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (1 genes) Metabolism Integration of energy metabolism Regulation of insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 1 genes Regulation of insulin secretion (1 genes) Metabolism Integration of energy metabolism Regulation of insulin secretion 1 genes	Adra2a Gene Information Basic Information Ensembl ID: ENSMUSG00000033717 Description: adrenergic receptor%2C alpha 2a [Source:MGI Symbol;Acc:MGI:87934] Location: 19:54032582-54037413 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte retina cell mural cell Other: Integration of energy metabolism Signaling by GPCR Surfactant metabolism Adra2c Gene Information Basic Information Ensembl ID: ENSMUSG00000045318 Description: adrenergic receptor%2C alpha 2c [Source:MGI Symbol;Acc:MGI:87936] Location: 5:35435663-35439107 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Integration of energy metabolism Signaling by GPCR Surfactant metabolism Gna11 Gene Information Basic Information Ensembl ID: ENSMUSG00000034781 Description: guanine nucleotide binding protein%2C alpha 11 [Source:MGI Symbol;Acc:MGI:95766] Location: 10:81364558-81381024 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell endothelial cell enterocyte Other: Integration of energy metabolism Signaling by GPCR Protein folding Gna14 Gene Information Basic Information Ensembl ID: ENSMUSG00000024697 Description: guanine nucleotide binding protein%2C alpha 14 [Source:MGI Symbol;Acc:MGI:95769] Location: 19:16413126-16588184 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell epithelial cell Other: Integration of energy metabolism Signaling by GPCR Protein folding Gnai1 Gene Information Basic Information Ensembl ID: ENSMUSG00000057614 Description: G protein subunit alpha i1 [Source:MGI Symbol;Acc:MGI:95771] Location: 5:18470133-18565353 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: mast cell adipocyte Other: Transmission across Chemical Synapses Integration of energy metabolism Signaling by GPCR Gnaq Gene Information Basic Information Ensembl ID: ENSMUSG00000024639 Description: guanine nucleotide binding protein%2C alpha q polypeptide [Source:MGI Symbol;Acc:MGI:95776] Location: 19:16110195-16364827 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: antigen presenting cell Other: Integration of energy metabolism Signaling by GPCR Protein folding Gngt2 Gene Information Basic Information Ensembl ID: ENSMUSG00000038811 Description: guanine nucleotide binding protein (G protein)%2C gamma transducing activity polypeptide 2 [Source:MGI Symbol;Acc:MGI:893584] Location: 11:95728042-95736560 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell dendritic cell phagocyte monocyte myeloid cell plasma cell macrophage photoreceptor cell Other: Platelet homeostasis Transmission across Chemical Synapses Potassium Channels Slc2a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000028645 Description: solute carrier family 2 (facilitated glucose transporter)%2C member 1 [Source:MGI Symbol;Acc:MGI:95755] Location: 4:118965908-118995180 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell epithelial cell Other: Integration of energy metabolism Metabolism of vitamins and cofactors SLC-mediated transmembrane transport
Integrin cell surface interactions Pathway Hierarchies & Genes Integrin cell surface interactions (32 genes) Extracellular matrix organization Integrin cell surface interactions 32 genes	Cd44 Gene Information Basic Information Ensembl ID: ENSMUSG00000005087 Description: CD44 antigen [Source:MGI Symbol;Acc:MGI:88338] Location: 2:102641486-102732010 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell phagocyte monocyte granulocyte neutrophil macrophage progenitor cell Other: Cell surface interactions at the vascular wall Integrin cell surface interactions Innate Immune System Col13a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000058806 Description: collagen%2C type XIII%2C alpha 1 [Source:MGI Symbol;Acc:MGI:1277201] Location: 10:61674015-61814887 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast endothelial cell osteoblast Other: Degradation of the extracellular matrix Collagen formation Integrin cell surface interactions Col1a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000001506 Description: collagen%2C type I%2C alpha 1 [Source:MGI Symbol;Acc:MGI:88467] Location: 11:94827050-94843868 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stellate cell pericyte stromal cell stem cell valve interstitial cell mesenchymal cell endothelial cell Other: ECM proteoglycans Platelet Adhesion to exposed collagen Adaptive Immune System Col1a2 Gene Information Basic Information Ensembl ID: ENSMUSG00000029661 Description: collagen%2C type I%2C alpha 2 [Source:MGI Symbol;Acc:MGI:88468] Location: 6:4504814-4541544 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stellate cell pericyte stem cell stromal cell epithelial cell vascular cell meningeal cell Other: Adaptive Immune System Degradation of the extracellular matrix Collagen formation Col5a2 Gene Information Basic Information Ensembl ID: ENSMUSG00000026042 Description: collagen%2C type V%2C alpha 2 [Source:MGI Symbol;Acc:MGI:88458] Location: 1:45413481-45542442 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast pericyte stellate cell stromal cell mesenchymal cell Other: Degradation of the extracellular matrix Collagen formation Fibronectin matrix formation Col6a2 Gene Information Basic Information Ensembl ID: ENSMUSG00000020241 Description: collagen%2C type VI%2C alpha 2 [Source:MGI Symbol;Acc:MGI:88460] Location: 10:76431596-76459464 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stellate cell pericyte pneumocyte stromal cell epithelial cell Other: Degradation of the extracellular matrix Collagen formation Integrin cell surface interactions Col6a3 Gene Information Basic Information Ensembl ID: ENSMUSG00000048126 Description: collagen%2C type VI%2C alpha 3 [Source:MGI Symbol;Acc:MGI:88461] Location: 1:90693645-90771693 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast pericyte stellate cell stromal cell Other: Degradation of the extracellular matrix Collagen formation Integrin cell surface interactions F11r Gene Information Basic Information Ensembl ID: ENSMUSG00000038235 Description: F11 receptor [Source:MGI Symbol;Acc:MGI:1321398] Location: 1:171265103-171292171 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stem cell phagocyte epithelial cell Other: Cell surface interactions at the vascular wall Integrin cell surface interactions Cell junction organization Icam1 Gene Information Basic Information Ensembl ID: ENSMUSG00000037405 Description: intercellular adhesion molecule 1 [Source:MGI Symbol;Acc:MGI:96392] Location: 9:20927281-20940113 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stem cell pneumocyte Other: Adaptive Immune System Integrin cell surface interactions Itga1 Gene Information Basic Information Ensembl ID: ENSMUSG00000042284 Description: integrin alpha 1 [Source:MGI Symbol;Acc:MGI:96599] Location: 13:115089632-115238500 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell pericyte stellate cell epithelial cell mural cell Other: Integrin cell surface interactions Smooth Muscle Contraction Itga10 Gene Information Basic Information Ensembl ID: ENSMUSG00000090210 Description: integrin%2C alpha 10 [Source:MGI Symbol;Acc:MGI:2153482] Location: 3:96552900-96571835 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: osteoblast Other: Integrin cell surface interactions Itga2 Gene Information Basic Information Ensembl ID: ENSMUSG00000015533 Description: integrin alpha 2 [Source:MGI Symbol;Acc:MGI:96600] Location: 13:114969617-115068636 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Specialized T cell Other: Integrin cell surface interactions Non-integrin membrane-ECM interactions ECM proteoglycans Itga2b Gene Information Basic Information Ensembl ID: ENSMUSG00000034664 Description: integrin alpha 2b [Source:MGI Symbol;Acc:MGI:96601] Location: 11:102344123-102360948 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stromal cell mast cell megakaryocyte erythrocyte progenitor cell basophil stellate cell Other: Integrin cell surface interactions ECM proteoglycans Integrin signaling Itga3 Gene Information Basic Information Ensembl ID: ENSMUSG00000001507 Description: integrin alpha 3 [Source:MGI Symbol;Acc:MGI:96602] Location: 11:94935300-94967627 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Cell surface interactions at the vascular wall Integrin cell surface interactions Laminin interactions Itga4 Gene Information Basic Information Ensembl ID: ENSMUSG00000027009 Description: integrin alpha 4 [Source:MGI Symbol;Acc:MGI:96603] Location: 2:79085770-79163467 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell Regulatory T cell CD8+ T cell monocyte T cell Specialized T cell Other: Adaptive Immune System Cell surface interactions at the vascular wall Integrin cell surface interactions Itga5 Gene Information Basic Information Ensembl ID: ENSMUSG00000000555 Description: integrin alpha 5 (fibronectin receptor alpha) [Source:MGI Symbol;Acc:MGI:96604] Location: 15:103252713-103275190 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Elastic fibre formation Fibronectin matrix formation Cell surface interactions at the vascular wall Itga6 Gene Information Basic Information Ensembl ID: ENSMUSG00000027111 Description: integrin alpha 6 [Source:MGI Symbol;Acc:MGI:96605] Location: 2:71575960-71688760 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell epithelial cell progenitor cell Other: Cell surface interactions at the vascular wall Integrin cell surface interactions Laminin interactions Itga8 Gene Information Basic Information Ensembl ID: ENSMUSG00000026768 Description: integrin alpha 8 [Source:MGI Symbol;Acc:MGI:109442] Location: 2:12111443-12306733 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast smooth muscle cell epithelial cell mesenchymal stem cell Other: Elastic fibre formation Integrin cell surface interactions ECM proteoglycans Itga9 Gene Information Basic Information Ensembl ID: ENSMUSG00000039115 Description: integrin alpha 9 [Source:MGI Symbol;Acc:MGI:104756] Location: 9:118435758-118730071 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stromal cell pneumocyte Other: Integrin cell surface interactions ECM proteoglycans Nervous system development Itgad Gene Information Basic Information Ensembl ID: ENSMUSG00000070369 Description: integrin%2C alpha D [Source:MGI Symbol;Acc:MGI:3578624] Location: 7:127753548-127822988 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Integrin cell surface interactions Itgal Gene Information Basic Information Ensembl ID: ENSMUSG00000030830 Description: integrin alpha L [Source:MGI Symbol;Acc:MGI:96606] Location: 7:126895432-126934310 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell CD4+ T cell CD8+ T cell monocyte Specialized T cell Other: Adaptive Immune System Innate Immune System Cell surface interactions at the vascular wall Itgam Gene Information Basic Information Ensembl ID: ENSMUSG00000030786 Description: integrin alpha M [Source:MGI Symbol;Acc:MGI:96607] Location: 7:127661812-127717663 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell phagocyte macrophage monocyte myeloid cell dendritic cell microglia myeloid derived suppressor cell immune cell Other: Innate Immune System Cell surface interactions at the vascular wall Integrin cell surface interactions Itgav Gene Information Basic Information Ensembl ID: ENSMUSG00000027087 Description: integrin alpha V [Source:MGI Symbol;Acc:MGI:96608] Location: 2:83554741-83637260 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell bone cell Other: ECM proteoglycans Non-integrin membrane-ECM interactions Adaptive Immune System Itgax Gene Information Basic Information Ensembl ID: ENSMUSG00000030789 Description: integrin alpha X [Source:MGI Symbol;Acc:MGI:96609] Location: 7:127728719-127749829 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell phagocyte macrophage dendritic cell Other: Innate Immune System Cell surface interactions at the vascular wall Integrin cell surface interactions Itgb2 Gene Information Basic Information Ensembl ID: ENSMUSG00000000290 Description: integrin beta 2 [Source:MGI Symbol;Acc:MGI:96611] Location: 10:77366086-77401542 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell monocyte neutrophil Other: Adaptive Immune System Innate Immune System Cell surface interactions at the vascular wall Itgb3 Gene Information Basic Information Ensembl ID: ENSMUSG00000020689 Description: integrin beta 3 [Source:MGI Symbol;Acc:MGI:96612] Location: 11:104498826-104561302 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell stromal cell bone cell megakaryocyte Other: Elastic fibre formation Cell surface interactions at the vascular wall Integrin cell surface interactions Jam3 Gene Information Basic Information Ensembl ID: ENSMUSG00000031990 Description: junction adhesion molecule 3 [Source:MGI Symbol;Acc:MGI:1933825] Location: 9:27008680-27066717 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell glial cell muscle cell schwann cell dendritic cell Other: Cell surface interactions at the vascular wall Integrin cell surface interactions Lum Gene Information Basic Information Ensembl ID: ENSMUSG00000036446 Description: lumican [Source:MGI Symbol;Acc:MGI:109347] Location: 10:97400990-97408565 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stellate cell stem cell stromal cell epithelial cell Other: Integrin cell surface interactions Metabolism of carbohydrates and carbohydrate derivatives Pecam1 Gene Information Basic Information Ensembl ID: ENSMUSG00000020717 Description: platelet/endothelial cell adhesion molecule 1 [Source:MGI Symbol;Acc:MGI:97537] Location: 11:106545043-106641454 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell epithelial cell Other: Innate Immune System Cell surface interactions at the vascular wall Integrin cell surface interactions Thbs1 Gene Information Basic Information Ensembl ID: ENSMUSG00000040152 Description: thrombospondin 1 [Source:MGI Symbol;Acc:MGI:98737] Location: 2:117942357-117957614 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell fibroblast phagocyte epithelial cell monocyte mural cell megakaryocyte dendritic cell Other: Integrin cell surface interactions Post-translational protein modification Platelet activation, signaling and aggregation Tnc Gene Information Basic Information Ensembl ID: ENSMUSG00000028364 Description: tenascin C [Source:MGI Symbol;Acc:MGI:101922] Location: 4:63878022-63965252 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell fibroblast epithelial cell glial cell smooth muscle cell Other: Integrin cell surface interactions ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Vcam1 Gene Information Basic Information Ensembl ID: ENSMUSG00000027962 Description: vascular cell adhesion molecule 1 [Source:MGI Symbol;Acc:MGI:98926] Location: 3:115903598-115923337 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell fibroblast phagocyte stem cell stromal cell muscle cell macrophage kupffer cell Other: Adaptive Immune System Integrin cell surface interactions
Integrin signaling Pathway Hierarchies & Genes p130Cas linkage to MAPK signaling for integrins (7 genes) Signal Transduction Integrin signaling 2 genes GRB2:SOS provides linkage to MAPK signaling for Integrins 2 genes p130Cas linkage to MAPK signaling for integrins 3 genes	Bcar1 Gene Information Basic Information Ensembl ID: ENSMUSG00000031955 Description: breast cancer anti-estrogen resistance 1 [Source:MGI Symbol;Acc:MGI:108091] Location: 8:112437106-112470441 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Integrin signaling Platelet activation, signaling and aggregation Signaling by Non-Receptor Tyrosine Kinases Itga2b Gene Information Basic Information Ensembl ID: ENSMUSG00000034664 Description: integrin alpha 2b [Source:MGI Symbol;Acc:MGI:96601] Location: 11:102344123-102360948 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stromal cell mast cell megakaryocyte erythrocyte progenitor cell basophil stellate cell Other: Integrin cell surface interactions ECM proteoglycans Integrin signaling Itgb3 Gene Information Basic Information Ensembl ID: ENSMUSG00000020689 Description: integrin beta 3 [Source:MGI Symbol;Acc:MGI:96612] Location: 11:104498826-104561302 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell stromal cell bone cell megakaryocyte Other: Elastic fibre formation Cell surface interactions at the vascular wall Integrin cell surface interactions Shc1 Gene Information Basic Information Ensembl ID: ENSMUSG00000042626 Description: src homology 2 domain-containing transforming protein C1 [Source:MGI Symbol;Acc:MGI:98296] Location: 3:89325750-89337334 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Innate Immune System Cell surface interactions at the vascular wall Sos1 Gene Information Basic Information Ensembl ID: ENSMUSG00000024241 Description: SOS Ras/Rac guanine nucleotide exchange factor 1 [Source:MGI Symbol;Acc:MGI:98354] Location: 17:80701180-80787882 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Syk Gene Information Basic Information Ensembl ID: ENSMUSG00000021457 Description: spleen tyrosine kinase [Source:MGI Symbol;Acc:MGI:99515] Location: 13:52737209-52802828 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell Naive B cell monocyte granulocyte Other: Integrin signaling Cytokine Signaling in Immune system Adaptive Immune System Tln1 Gene Information Basic Information Ensembl ID: ENSMUSG00000028465 Description: talin 1 [Source:MGI Symbol;Acc:MGI:1099832] Location: 4:43531519-43562691 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell phagocyte monocyte eosinophil megakaryocyte dendritic cell Other: Integrin signaling Smooth Muscle Contraction MAPK family signaling cascades
Intracellular signaling by second messengers Pathway Hierarchies & Genes Calmodulin induced events (1 genes) Signal Transduction Intracellular signaling by second messengers DAG and IP3 signaling CaM pathway Calmodulin induced events 1 genes PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (27 genes) Signal Transduction Intracellular signaling by second messengers PIP3 activates AKT signaling Negative regulation of the PI3K/AKT network PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 27 genes Regulation of PTEN gene transcription (1 genes) Signal Transduction Intracellular signaling by second messengers PIP3 activates AKT signaling PTEN Regulation Regulation of PTEN gene transcription 1 genes Regulation of PTEN stability and activity (1 genes) Signal Transduction Intracellular signaling by second messengers PIP3 activates AKT signaling PTEN Regulation Regulation of PTEN stability and activity 1 genes AKT phosphorylates targets in the nucleus (1 genes) Signal Transduction Intracellular signaling by second messengers PIP3 activates AKT signaling AKT phosphorylates targets in the nucleus 1 genes PIP3 activates AKT signaling (1 genes) Signal Transduction Intracellular signaling by second messengers PIP3 activates AKT signaling 1 genes	Bdnf Gene Information Basic Information Ensembl ID: ENSMUSG00000048482 Description: brain derived neurotrophic factor [Source:MGI Symbol;Acc:MGI:88145] Location: 2:109505045-109557352 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Cd28 Gene Information Basic Information Ensembl ID: ENSMUSG00000026012 Description: CD28 antigen [Source:MGI Symbol;Acc:MGI:88327] Location: 1:60755959-60812518 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell Regulatory T cell CD4+ T cell Specialized T cell T cell Other: Adaptive Immune System Intracellular signaling by second messengers Creb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000025958 Description: cAMP responsive element binding protein 1 [Source:MGI Symbol;Acc:MGI:88494] Location: 1:64571804-64643707 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Transmission across Chemical Synapses Cytokine Signaling in Immune system Innate Immune System Esr1 Gene Information Basic Information Ensembl ID: ENSMUSG00000019768 Description: estrogen receptor 1 (alpha) [Source:MGI Symbol;Acc:MGI:1352467] Location: 10:4561593-4955614 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by Receptor Tyrosine Kinases Cellular responses to stress Post-translational protein modification Fgf10 Gene Information Basic Information Ensembl ID: ENSMUSG00000021732 Description: fibroblast growth factor 10 [Source:MGI Symbol;Acc:MGI:1099809] Location: 13:118806327-118928651 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: cochleovestibular ganglion cell Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Fgf7 Gene Information Basic Information Ensembl ID: ENSMUSG00000027208 Description: fibroblast growth factor 7 [Source:MGI Symbol;Acc:MGI:95521] Location: 2:125876578-125933105 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Fgfr1 Gene Information Basic Information Ensembl ID: ENSMUSG00000031565 Description: fibroblast growth factor receptor 1 [Source:MGI Symbol;Acc:MGI:95522] Location: 8:26003670-26065734 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast chondrocyte muscle cell osteoblast Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Fgfr3 Gene Information Basic Information Ensembl ID: ENSMUSG00000054252 Description: fibroblast growth factor receptor 3 [Source:MGI Symbol;Acc:MGI:95524] Location: 5:33879018-33894412 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell astrocyte supporting cell Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Fgfr4 Gene Information Basic Information Ensembl ID: ENSMUSG00000005320 Description: fibroblast growth factor receptor 4 [Source:MGI Symbol;Acc:MGI:95525] Location: 13:55300453-55316572 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stem cell muscle cell Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Frs2 Gene Information Basic Information Ensembl ID: ENSMUSG00000020170 Description: fibroblast growth factor receptor substrate 2 [Source:MGI Symbol;Acc:MGI:1100860] Location: 10:116905332-116984439 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Fyn Gene Information Basic Information Ensembl ID: ENSMUSG00000019843 Description: Fyn proto-oncogene [Source:MGI Symbol;Acc:MGI:95602] Location: 10:39244851-39441377 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cell surface interactions at the vascular wall Nephrin family interactions Cytokine Signaling in Immune system Gab1 Gene Information Basic Information Ensembl ID: ENSMUSG00000031714 Description: growth factor receptor bound protein 2-associated protein 1 [Source:MGI Symbol;Acc:MGI:108088] Location: 8:81491063-81607148 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte Other: Signaling by Erythropoietin Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Grk2 Gene Information Basic Information Ensembl ID: ENSMUSG00000024858 Description: G protein-coupled receptor kinase 2 [Source:MGI Symbol;Acc:MGI:87940] Location: 19:4336029-4356250 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Membrane Trafficking Signaling by GPCR Signaling by Hedgehog Il1rap Gene Information Basic Information Ensembl ID: ENSMUSG00000022514 Description: interleukin 1 receptor accessory protein [Source:MGI Symbol;Acc:MGI:104975] Location: 16:26400454-26548867 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell bipolar cell neuron Other: Cytokine Signaling in Immune system Protein-protein interactions at synapses Intracellular signaling by second messengers Il1rl1 Gene Information Basic Information Ensembl ID: ENSMUSG00000026069 Description: interleukin 1 receptor-like 1 [Source:MGI Symbol;Acc:MGI:98427] Location: 1:40468730-40504575 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell natural killer cell mast cell Other: Cytokine Signaling in Immune system Intracellular signaling by second messengers Il33 Gene Information Basic Information Ensembl ID: ENSMUSG00000024810 Description: interleukin 33 [Source:MGI Symbol;Acc:MGI:1924375] Location: 19:29902514-29938118 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stellate cell pneumocyte stem cell fibroblast epithelial cell glial cell oligodendrocyte Other: Cytokine Signaling in Immune system Post-translational protein modification Intracellular signaling by second messengers Irak1 Gene Information Basic Information Ensembl ID: ENSMUSG00000031392 Description: interleukin-1 receptor-associated kinase 1 [Source:MGI Symbol;Acc:MGI:107420] Location: X:73057520-73067524 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Innate Immune System Death Receptor Signaling Irak4 Gene Information Basic Information Ensembl ID: ENSMUSG00000059883 Description: interleukin-1 receptor-associated kinase 4 [Source:MGI Symbol;Acc:MGI:2182474] Location: 15:94441524-94479696 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Intracellular signaling by second messengers Irs2 Gene Information Basic Information Ensembl ID: ENSMUSG00000038894 Description: insulin receptor substrate 2 [Source:MGI Symbol;Acc:MGI:109334] Location: 8:11034681-11058458 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: mural cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades Signaling by Erythropoietin Kitl Gene Information Basic Information Ensembl ID: ENSMUSG00000019966 Description: kit ligand [Source:MGI Symbol;Acc:MGI:96974] Location: 10:99851492-99936278 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stromal cell Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Klb Gene Information Basic Information Ensembl ID: ENSMUSG00000029195 Description: klotho beta [Source:MGI Symbol;Acc:MGI:1932466] Location: 5:65505657-65541350 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: adipocyte Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Met Gene Information Basic Information Ensembl ID: ENSMUSG00000009376 Description: met proto-oncogene [Source:MGI Symbol;Acc:MGI:96969] Location: 6:17463799-17573979 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell intercalated cell Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Myd88 Gene Information Basic Information Ensembl ID: ENSMUSG00000032508 Description: myeloid differentiation primary response gene 88 [Source:MGI Symbol;Acc:MGI:108005] Location: 9:119165000-119170477 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Innate Immune System Death Receptor Signaling Ntf3 Gene Information Basic Information Ensembl ID: ENSMUSG00000049107 Description: neurotrophin 3 [Source:MGI Symbol;Acc:MGI:97380] Location: 6:126078375-126143873 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: smooth muscle cell Other: Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Ntrk2 Gene Information Basic Information Ensembl ID: ENSMUSG00000055254 Description: neurotrophic tyrosine kinase%2C receptor%2C type 2 [Source:MGI Symbol;Acc:MGI:97384] Location: 13:58954383-59281784 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast glial cell neuron astrocyte Other: Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Ppp2ca Gene Information Basic Information Ensembl ID: ENSMUSG00000020349 Description: protein phosphatase 2 (formerly 2A)%2C catalytic subunit%2C alpha isoform [Source:MGI Symbol;Acc:MGI:1321159] Location: 11:51989508-52018605 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Prr5 Gene Information Basic Information Ensembl ID: ENSMUSG00000036106 Description: proline rich 5 (renal) [Source:MGI Symbol;Acc:MGI:1924714] Location: 15:84553821-84587874 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: plasma cell Other: Adaptive Immune System RNA Polymerase II Transcription Intracellular signaling by second messengers Ptpn11 Gene Information Basic Information Ensembl ID: ENSMUSG00000043733 Description: protein tyrosine phosphatase%2C non-receptor type 11 [Source:MGI Symbol;Acc:MGI:99511] Location: 5:121268596-121329460 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Nervous system development Cytokine Signaling in Immune system Adaptive Immune System Rac2 Gene Information Basic Information Ensembl ID: ENSMUSG00000033220 Description: Rac family small GTPase 2 [Source:MGI Symbol;Acc:MGI:97846] Location: 15:78443367-78456983 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell dendritic cell developing T cell tuft cell CD4+ T cell mast cell T cell granulocyte leukocyte lymphocyte Other: Innate Immune System Signaling by WNT Platelet activation, signaling and aggregation Rragd Gene Information Basic Information Ensembl ID: ENSMUSG00000028278 Description: Ras-related GTP binding D [Source:MGI Symbol;Acc:MGI:1098604] Location: 4:32983037-33022180 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Macroautophagy MTOR signalling Cellular responses to stress Stub1 Gene Information Basic Information Ensembl ID: ENSMUSG00000039615 Description: STIP1 homology and U-Box containing protein 1 [Source:MGI Symbol;Acc:MGI:1891731] Location: 17:26049479-26052378 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Adaptive Immune System Regulated Necrosis RNA Polymerase II Transcription Traf6 Gene Information Basic Information Ensembl ID: ENSMUSG00000027164 Description: TNF receptor-associated factor 6 [Source:MGI Symbol;Acc:MGI:108072] Location: 2:101508774-101532014 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Post-translational protein modification Cytokine Signaling in Immune system Adaptive Immune System
Ion channel transport Pathway Hierarchies & Genes TRP channels (7 genes) Transport of small molecules Ion channel transport Stimuli-sensing channels 4 genes TRP channels 3 genes	Ano6 Gene Information Basic Information Ensembl ID: ENSMUSG00000064210 Description: anoctamin 6 [Source:MGI Symbol;Acc:MGI:2145890] Location: 15:95688724-95872632 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell Other: Innate Immune System Ion channel transport Atp10d Gene Information Basic Information Ensembl ID: ENSMUSG00000046808 Description: ATPase%2C class V%2C type 10D [Source:MGI Symbol;Acc:MGI:2450125] Location: 5:72360672-72456118 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Ion channel transport Atp1a3 Gene Information Basic Information Ensembl ID: ENSMUSG00000040907 Description: ATPase%2C Na+/K+ transporting%2C alpha 3 polypeptide [Source:MGI Symbol;Acc:MGI:88107] Location: 7:24677592-24705383 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Cardiac conduction Ion channel transport Mlkl Gene Information Basic Information Ensembl ID: ENSMUSG00000012519 Description: mixed lineage kinase domain-like [Source:MGI Symbol;Acc:MGI:1921818] Location: 8:112038429-112064809 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Regulated Necrosis Ion channel transport Ripk1 Gene Information Basic Information Ensembl ID: ENSMUSG00000021408 Description: receptor (TNFRSF)-interacting serine-threonine kinase 1 [Source:MGI Symbol;Acc:MGI:108212] Location: 13:34186346-34221130 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Apoptosis Innate Immune System Regulated Necrosis Trpm2 Gene Information Basic Information Ensembl ID: ENSMUSG00000009292 Description: transient receptor potential cation channel%2C subfamily M%2C member 2 [Source:MGI Symbol;Acc:MGI:1351901] Location: 10:77743556-77806397 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: kupffer cell Other: Innate Immune System Ion channel transport Ttyh1 Gene Information Basic Information Ensembl ID: ENSMUSG00000030428 Description: tweety family member 1 [Source:MGI Symbol;Acc:MGI:1889007] Location: 7:4122407-4139707 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: bergmann glial cell neuron glial cell Other: Ion channel transport
Iron uptake and transport Pathway Hierarchies & Genes Transferrin endocytosis and recycling (2 genes) Transport of small molecules Iron uptake and transport 1 genes Transferrin endocytosis and recycling 1 genes	Hfe Gene Information Basic Information Ensembl ID: ENSMUSG00000006611 Description: homeostatic iron regulator [Source:MGI Symbol;Acc:MGI:109191] Location: 13:23886017-23894837 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell smooth muscle cell monocyte macrophage Other: Iron uptake and transport Slc40a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000025993 Description: solute carrier family 40 (iron-regulated transporter)%2C member 1 [Source:MGI Symbol;Acc:MGI:1315204] Location: 1:45947228-45965683 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte myeloid cell Other: SLC-mediated transmembrane transport Iron uptake and transport
Keratinization Pathway Hierarchies & Genes Formation of the cornified envelope (2 genes) Developmental Biology Keratinization Formation of the cornified envelope 2 genes Formation of the cornified envelope (7 genes) Developmental Biology Keratinization Formation of the cornified envelope 7 genes	Dsc2 Gene Information Basic Information Ensembl ID: ENSMUSG00000024331 Description: desmocollin 2 [Source:MGI Symbol;Acc:MGI:103221] Location: 18:20163690-20192611 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Keratinization Dsg2 Gene Information Basic Information Ensembl ID: ENSMUSG00000044393 Description: desmoglein 2 [Source:MGI Symbol;Acc:MGI:1196466] Location: 18:20691131-20737578 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell tuft cell epithelial cell Other: Apoptosis Keratinization Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Dsp Gene Information Basic Information Ensembl ID: ENSMUSG00000054889 Description: desmoplakin [Source:MGI Symbol;Acc:MGI:109611] Location: 13:38335270-38382553 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell tuft cell skeletal muscle cell basal cell Other: Apoptosis Innate Immune System Keratinization Jup Gene Information Basic Information Ensembl ID: ENSMUSG00000001552 Description: junction plakoglobin [Source:MGI Symbol;Acc:MGI:96650] Location: 11:100259784-100288589 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stellate cell stem cell epithelial cell smooth muscle cell keratinocyte basal cell Other: Innate Immune System Cell junction organization Keratinization Krt23 Gene Information Basic Information Ensembl ID: ENSMUSG00000006777 Description: keratin 23 [Source:MGI Symbol;Acc:MGI:2148866] Location: 11:99368800-99383963 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: tuft cell epithelial cell Other: Keratinization Perp Gene Information Basic Information Ensembl ID: ENSMUSG00000019851 Description: PERP%2C TP53 apoptosis effector [Source:MGI Symbol;Acc:MGI:1929938] Location: 10:18720768-18732821 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Keratinization Pkp2 Gene Information Basic Information Ensembl ID: ENSMUSG00000041957 Description: plakophilin 2 [Source:MGI Symbol;Acc:MGI:1914701] Location: 16:16031182-16090576 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: cardiomyocyte Other: Keratinization Pkp3 Gene Information Basic Information Ensembl ID: ENSMUSG00000054065 Description: plakophilin 3 [Source:MGI Symbol;Acc:MGI:1891830] Location: 7:140658131-140670423 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell Regulatory T cell CD4+ T cell epithelial cell T cell keratinocyte Other: Keratinization Pkp4 Gene Information Basic Information Ensembl ID: ENSMUSG00000026991 Description: plakophilin 4 [Source:MGI Symbol;Acc:MGI:109281] Location: 2:58991194-59185552 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell endothelial cell Other: Keratinization Signaling by Rho GTPases, Miro GTPases and RHOBTB3
LGI-ADAM interactions Pathway Hierarchies & Genes LGI-ADAM interactions (1 genes) Developmental Biology LGI-ADAM interactions 1 genes	Dlg4 Gene Information Basic Information Ensembl ID: ENSMUSG00000020886 Description: discs large MAGUK scaffold protein 4 [Source:MGI Symbol;Acc:MGI:1277959] Location: 11:69907768-69938348 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: photoreceptor cell Other: Transmission across Chemical Synapses LGI-ADAM interactions MAPK family signaling cascades
Laminin interactions Pathway Hierarchies & Genes Laminin interactions (5 genes) Extracellular matrix organization Laminin interactions 5 genes	Itga3 Gene Information Basic Information Ensembl ID: ENSMUSG00000001507 Description: integrin alpha 3 [Source:MGI Symbol;Acc:MGI:96602] Location: 11:94935300-94967627 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Cell surface interactions at the vascular wall Integrin cell surface interactions Laminin interactions Itga6 Gene Information Basic Information Ensembl ID: ENSMUSG00000027111 Description: integrin alpha 6 [Source:MGI Symbol;Acc:MGI:96605] Location: 2:71575960-71688760 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell epithelial cell progenitor cell Other: Cell surface interactions at the vascular wall Integrin cell surface interactions Laminin interactions Itga7 Gene Information Basic Information Ensembl ID: ENSMUSG00000025348 Description: integrin alpha 7 [Source:MGI Symbol;Acc:MGI:102700] Location: 10:128769645-128794155 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: mural cell Other: Laminin interactions ECM proteoglycans Itgb4 Gene Information Basic Information Ensembl ID: ENSMUSG00000020758 Description: integrin beta 4 [Source:MGI Symbol;Acc:MGI:96613] Location: 11:115865535-115899238 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell basal cell cardiomyocyte perineurial cell Other: Laminin interactions Non-integrin membrane-ECM interactions Cell junction organization Nid1 Gene Information Basic Information Ensembl ID: ENSMUSG00000005397 Description: nidogen 1 [Source:MGI Symbol;Acc:MGI:97342] Location: 13:13612136-13686854 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast pericyte stem cell glial cell stromal cell Other: Degradation of the extracellular matrix Laminin interactions
MAPK family signaling cascades Pathway Hierarchies & Genes MAPK6/MAPK4 signaling (6 genes) Signal Transduction MAPK family signaling cascades MAPK1/MAPK3 signaling RAF-independent MAPK1/3 activation MAPK3 (ERK1) activation 5 genes MAPK6/MAPK4 signaling 1 genes MAP2K and MAPK activation (7 genes) Signal Transduction MAPK family signaling cascades MAPK1/MAPK3 signaling RAF/MAP kinase cascade MAP2K and MAPK activation 7 genes Negative regulation of MAPK pathway (2 genes) Signal Transduction MAPK family signaling cascades MAPK1/MAPK3 signaling RAF/MAP kinase cascade Negative regulation of MAPK pathway 2 genes RAF activation (1 genes) Signal Transduction MAPK family signaling cascades MAPK1/MAPK3 signaling RAF/MAP kinase cascade RAF activation 1 genes Regulation of RAS by GAPs (4 genes) Signal Transduction MAPK family signaling cascades MAPK1/MAPK3 signaling RAF/MAP kinase cascade Regulation of RAS by GAPs 4 genes RAF/MAP kinase cascade (26 genes) Signal Transduction MAPK family signaling cascades MAPK1/MAPK3 signaling RAF/MAP kinase cascade 26 genes MAPK6/MAPK4 signaling (3 genes) Signal Transduction MAPK family signaling cascades MAPK6/MAPK4 signaling 3 genes	Angpt1 Gene Information Basic Information Ensembl ID: ENSMUSG00000022309 Description: angiopoietin 1 [Source:MGI Symbol;Acc:MGI:108448] Location: 15:42288119-42540373 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast preadipocyte cardiomyocyte astrocyte Other: Cell surface interactions at the vascular wall MAPK family signaling cascades Arrb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000018909 Description: arrestin%2C beta 1 [Source:MGI Symbol;Acc:MGI:99473] Location: 7:99184673-99255978 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stromal cell Other: Membrane Trafficking Signaling by GPCR Signaling by Hedgehog Arrb2 Gene Information Basic Information Ensembl ID: ENSMUSG00000060216 Description: arrestin%2C beta 2 [Source:MGI Symbol;Acc:MGI:99474] Location: 11:70323461-70331654 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell antigen presenting cell Other: Signaling by WNT Membrane Trafficking Signaling by GPCR Cdc42 Gene Information Basic Information Ensembl ID: ENSMUSG00000006699 Description: cell division cycle 42 [Source:MGI Symbol;Acc:MGI:106211] Location: 4:137047007-137085031 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: hematopoietic stem cell phagocyte antigen presenting cell macrophage dendritic cell Other: Adaptive Immune System Innate Immune System Signaling by GPCR Cdk1 Gene Information Basic Information Ensembl ID: ENSMUSG00000019942 Description: cyclin dependent kinase 1 [Source:MGI Symbol;Acc:MGI:88351] Location: 10:69170976-69188768 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: proliferative cell Other: Cytokine Signaling in Immune system Cilium Assembly MAPK family signaling cascades Dab2ip Gene Information Basic Information Ensembl ID: ENSMUSG00000026883 Description: disabled 2 interacting protein [Source:MGI Symbol;Acc:MGI:1916851] Location: 2:35448278-35621006 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: MAPK family signaling cascades Dlg1 Gene Information Basic Information Ensembl ID: ENSMUSG00000022770 Description: discs large MAGUK scaffold protein 1 [Source:MGI Symbol;Acc:MGI:107231] Location: 16:31482261-31693947 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell ectodermal cell Other: Transmission across Chemical Synapses MAPK family signaling cascades Protein-protein interactions at synapses Dlg2 Gene Information Basic Information Ensembl ID: ENSMUSG00000052572 Description: discs large MAGUK scaffold protein 2 [Source:MGI Symbol;Acc:MGI:1344351] Location: 7:90125880-92098455 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron epithelial cell Other: Transmission across Chemical Synapses MAPK family signaling cascades Protein-protein interactions at synapses Dlg3 Gene Information Basic Information Ensembl ID: ENSMUSG00000000881 Description: discs large MAGUK scaffold protein 3 [Source:MGI Symbol;Acc:MGI:1888986] Location: X:99811328-99862016 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Transmission across Chemical Synapses MAPK family signaling cascades Protein-protein interactions at synapses Dlg4 Gene Information Basic Information Ensembl ID: ENSMUSG00000020886 Description: discs large MAGUK scaffold protein 4 [Source:MGI Symbol;Acc:MGI:1277959] Location: 11:69907768-69938348 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: photoreceptor cell Other: Transmission across Chemical Synapses LGI-ADAM interactions MAPK family signaling cascades Dnajb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000005483 Description: DnaJ heat shock protein family (Hsp40) member B1 [Source:MGI Symbol;Acc:MGI:1931874] Location: 8:84334822-84339282 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stem cell basal cell Other: Cellular responses to stress MAPK family signaling cascades Dusp10 Gene Information Basic Information Ensembl ID: ENSMUSG00000039384 Description: dual specificity phosphatase 10 [Source:MGI Symbol;Acc:MGI:1927070] Location: 1:183745499-183807833 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell adipocyte Other: MAPK family signaling cascades Fgf10 Gene Information Basic Information Ensembl ID: ENSMUSG00000021732 Description: fibroblast growth factor 10 [Source:MGI Symbol;Acc:MGI:1099809] Location: 13:118806327-118928651 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: cochleovestibular ganglion cell Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Fgf7 Gene Information Basic Information Ensembl ID: ENSMUSG00000027208 Description: fibroblast growth factor 7 [Source:MGI Symbol;Acc:MGI:95521] Location: 2:125876578-125933105 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Fgfr1 Gene Information Basic Information Ensembl ID: ENSMUSG00000031565 Description: fibroblast growth factor receptor 1 [Source:MGI Symbol;Acc:MGI:95522] Location: 8:26003670-26065734 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast chondrocyte muscle cell osteoblast Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Fgfr3 Gene Information Basic Information Ensembl ID: ENSMUSG00000054252 Description: fibroblast growth factor receptor 3 [Source:MGI Symbol;Acc:MGI:95524] Location: 5:33879018-33894412 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell astrocyte supporting cell Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Fgfr4 Gene Information Basic Information Ensembl ID: ENSMUSG00000005320 Description: fibroblast growth factor receptor 4 [Source:MGI Symbol;Acc:MGI:95525] Location: 13:55300453-55316572 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stem cell muscle cell Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Frs2 Gene Information Basic Information Ensembl ID: ENSMUSG00000020170 Description: fibroblast growth factor receptor substrate 2 [Source:MGI Symbol;Acc:MGI:1100860] Location: 10:116905332-116984439 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Fyn Gene Information Basic Information Ensembl ID: ENSMUSG00000019843 Description: Fyn proto-oncogene [Source:MGI Symbol;Acc:MGI:95602] Location: 10:39244851-39441377 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cell surface interactions at the vascular wall Nephrin family interactions Cytokine Signaling in Immune system Gdnf Gene Information Basic Information Ensembl ID: ENSMUSG00000022144 Description: glial cell line derived neurotrophic factor [Source:MGI Symbol;Acc:MGI:107430] Location: 15:7840327-7867056 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: MAPK family signaling cascades Nervous system development Il17rd Gene Information Basic Information Ensembl ID: ENSMUSG00000040717 Description: interleukin 17 receptor D [Source:MGI Symbol;Acc:MGI:2159727] Location: 14:26760898-26829243 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: MAPK family signaling cascades Il2ra Gene Information Basic Information Ensembl ID: ENSMUSG00000026770 Description: interleukin 2 receptor%2C alpha chain [Source:MGI Symbol;Acc:MGI:96549] Location: 2:11647618-11698004 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Regulatory T cell T cell CD8+ T cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades Il2rb Gene Information Basic Information Ensembl ID: ENSMUSG00000068227 Description: interleukin 2 receptor%2C beta chain [Source:MGI Symbol;Acc:MGI:96550] Location: 15:78363456-78379471 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell developing T cell Specialized T cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades Il2rg Gene Information Basic Information Ensembl ID: ENSMUSG00000031304 Description: interleukin 2 receptor%2C gamma chain [Source:MGI Symbol;Acc:MGI:96551] Location: X:100307984-100311861 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell developing T cell fibroblast Regulatory T cell CD4+ T cell endothelial cell hematopoietic cell innate lymphoid cell lymphocyte Other: Cytokine Signaling in Immune system MAPK family signaling cascades Il5ra Gene Information Basic Information Ensembl ID: ENSMUSG00000005364 Description: interleukin 5 receptor%2C alpha [Source:MGI Symbol;Acc:MGI:96558] Location: 6:106687318-106725998 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system MAPK family signaling cascades Il6ra Gene Information Basic Information Ensembl ID: ENSMUSG00000027947 Description: interleukin 6 receptor%2C alpha [Source:MGI Symbol;Acc:MGI:105304] Location: 3:89771366-89820503 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte monocyte Other: Cytokine Signaling in Immune system MAPK family signaling cascades Il6st Gene Information Basic Information Ensembl ID: ENSMUSG00000021756 Description: interleukin 6 signal transducer [Source:MGI Symbol;Acc:MGI:96560] Location: 13:112600604-112646620 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades Iqgap1 Gene Information Basic Information Ensembl ID: ENSMUSG00000030536 Description: IQ motif containing GTPase activating protein 1 [Source:MGI Symbol;Acc:MGI:1352757] Location: 7:80361331-80475722 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell phagocyte epithelial cell macrophage monocyte granulocyte neutrophil Other: Innate Immune System Nephrin family interactions MAPK family signaling cascades Irs2 Gene Information Basic Information Ensembl ID: ENSMUSG00000038894 Description: insulin receptor substrate 2 [Source:MGI Symbol;Acc:MGI:109334] Location: 8:11034681-11058458 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: mural cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades Signaling by Erythropoietin Itga2b Gene Information Basic Information Ensembl ID: ENSMUSG00000034664 Description: integrin alpha 2b [Source:MGI Symbol;Acc:MGI:96601] Location: 11:102344123-102360948 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stromal cell mast cell megakaryocyte erythrocyte progenitor cell basophil stellate cell Other: Integrin cell surface interactions ECM proteoglycans Integrin signaling Itgb3 Gene Information Basic Information Ensembl ID: ENSMUSG00000020689 Description: integrin beta 3 [Source:MGI Symbol;Acc:MGI:96612] Location: 11:104498826-104561302 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell stromal cell bone cell megakaryocyte Other: Elastic fibre formation Cell surface interactions at the vascular wall Integrin cell surface interactions Jak2 Gene Information Basic Information Ensembl ID: ENSMUSG00000024789 Description: Janus kinase 2 [Source:MGI Symbol;Acc:MGI:96629] Location: 19:29229228-29290480 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell dendritic cell eosinophil Other: Cytokine Signaling in Immune system MAPK family signaling cascades Cell Cycle, Mitotic Kitl Gene Information Basic Information Ensembl ID: ENSMUSG00000019966 Description: kit ligand [Source:MGI Symbol;Acc:MGI:96974] Location: 10:99851492-99936278 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stromal cell Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Klb Gene Information Basic Information Ensembl ID: ENSMUSG00000029195 Description: klotho beta [Source:MGI Symbol;Acc:MGI:1932466] Location: 5:65505657-65541350 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: adipocyte Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Met Gene Information Basic Information Ensembl ID: ENSMUSG00000009376 Description: met proto-oncogene [Source:MGI Symbol;Acc:MGI:96969] Location: 6:17463799-17573979 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell intercalated cell Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Pak1 Gene Information Basic Information Ensembl ID: ENSMUSG00000030774 Description: p21 (RAC1) activated kinase 1 [Source:MGI Symbol;Acc:MGI:1339975] Location: 7:97437748-97561588 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell epithelial cell excitatory neuron Other: Adaptive Immune System Innate Immune System Signaling by GPCR Ppp2ca Gene Information Basic Information Ensembl ID: ENSMUSG00000020349 Description: protein phosphatase 2 (formerly 2A)%2C catalytic subunit%2C alpha isoform [Source:MGI Symbol;Acc:MGI:1321159] Location: 11:51989508-52018605 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Ptpn11 Gene Information Basic Information Ensembl ID: ENSMUSG00000043733 Description: protein tyrosine phosphatase%2C non-receptor type 11 [Source:MGI Symbol;Acc:MGI:99511] Location: 5:121268596-121329460 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Nervous system development Cytokine Signaling in Immune system Adaptive Immune System Ptpn7 Gene Information Basic Information Ensembl ID: ENSMUSG00000031506 Description: protein tyrosine phosphatase%2C non-receptor type 7 [Source:MGI Symbol;Acc:MGI:2156893] Location: 1:135060438-135073055 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell T cell Other: MAPK family signaling cascades Rapgef2 Gene Information Basic Information Ensembl ID: ENSMUSG00000062232 Description: Rap guanine nucleotide exchange factor (GEF) 2 [Source:MGI Symbol;Acc:MGI:2659071] Location: 3:78969823-79193824 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte endothelial cell mast cell Other: MAPK family signaling cascades Shc1 Gene Information Basic Information Ensembl ID: ENSMUSG00000042626 Description: src homology 2 domain-containing transforming protein C1 [Source:MGI Symbol;Acc:MGI:98296] Location: 3:89325750-89337334 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Innate Immune System Cell surface interactions at the vascular wall Shc2 Gene Information Basic Information Ensembl ID: ENSMUSG00000020312 Description: SHC (Src homology 2 domain containing) transforming protein 2 [Source:MGI Symbol;Acc:MGI:106180] Location: 10:79453885-79473752 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: MAPK family signaling cascades Signaling by Receptor Tyrosine Kinases Sos1 Gene Information Basic Information Ensembl ID: ENSMUSG00000024241 Description: SOS Ras/Rac guanine nucleotide exchange factor 1 [Source:MGI Symbol;Acc:MGI:98354] Location: 17:80701180-80787882 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Spred1 Gene Information Basic Information Ensembl ID: ENSMUSG00000027351 Description: sprouty protein with EVH-1 domain 1%2C related sequence [Source:MGI Symbol;Acc:MGI:2150016] Location: 2:116951855-117012760 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: adrenal cortical cell fibroblast Other: MAPK family signaling cascades Signaling by Receptor Tyrosine Kinases Spred2 Gene Information Basic Information Ensembl ID: ENSMUSG00000045671 Description: sprouty-related EVH1 domain containing 2 [Source:MGI Symbol;Acc:MGI:2150019] Location: 11:19874375-19974026 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: MAPK family signaling cascades Signaling by Receptor Tyrosine Kinases Spred3 Gene Information Basic Information Ensembl ID: ENSMUSG00000037239 Description: sprouty-related EVH1 domain containing 3 [Source:MGI Symbol;Acc:MGI:2142186] Location: 7:28858254-28869836 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: MAPK family signaling cascades Tek Gene Information Basic Information Ensembl ID: ENSMUSG00000006386 Description: TEK receptor tyrosine kinase [Source:MGI Symbol;Acc:MGI:98664] Location: 4:94627526-94763213 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Cell surface interactions at the vascular wall MAPK family signaling cascades Tln1 Gene Information Basic Information Ensembl ID: ENSMUSG00000028465 Description: talin 1 [Source:MGI Symbol;Acc:MGI:1099832] Location: 4:43531519-43562691 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell phagocyte monocyte eosinophil megakaryocyte dendritic cell Other: Integrin signaling Smooth Muscle Contraction MAPK family signaling cascades Tyk2 Gene Information Basic Information Ensembl ID: ENSMUSG00000032175 Description: tyrosine kinase 2 [Source:MGI Symbol;Acc:MGI:1929470] Location: 9:21015364-21042539 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades
MITF-M-regulated melanocyte development Pathway Hierarchies & Genes Regulation of MITF-M-dependent genes involved in cell cycle and proliferation (2 genes) Developmental Biology MITF-M-regulated melanocyte development MITF-M-dependent gene expression Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 2 genes Regulation of MITF-M-dependent genes involved in pigmentation (1 genes) Developmental Biology MITF-M-regulated melanocyte development MITF-M-dependent gene expression Regulation of MITF-M-dependent genes involved in pigmentation 1 genes Transcriptional and post-translational regulation of MITF-M expression and activity (3 genes) Developmental Biology MITF-M-regulated melanocyte development Transcriptional and post-translational regulation of MITF-M expression and activity 3 genes	Csf1 Gene Information Basic Information Ensembl ID: ENSMUSG00000014599 Description: colony stimulating factor 1 (macrophage) [Source:MGI Symbol;Acc:MGI:1339753] Location: 3:107648364-107667785 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell endothelial cell basophil eosinophil Other: Cytokine Signaling in Immune system Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein modification Ctnnb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000006932 Description: catenin beta 1 [Source:MGI Symbol;Acc:MGI:88276] Location: 9:120758282-120789573 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stem cell epithelial cell Other: Apoptosis Innate Immune System Signaling by WNT Gsk3b Gene Information Basic Information Ensembl ID: ENSMUSG00000022812 Description: glycogen synthase kinase 3 beta [Source:MGI Symbol;Acc:MGI:1861437] Location: 16:37909363-38066446 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by WNT Epigenetic regulation of gene expression Cellular responses to stress Kitl Gene Information Basic Information Ensembl ID: ENSMUSG00000019966 Description: kit ligand [Source:MGI Symbol;Acc:MGI:96974] Location: 10:99851492-99936278 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stromal cell Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Myo5a Gene Information Basic Information Ensembl ID: ENSMUSG00000034593 Description: myosin VA [Source:MGI Symbol;Acc:MGI:105976] Location: 9:74978297-75130970 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte antigen presenting cell Other: Innate Immune System MITF-M-regulated melanocyte development Tcf7l2 Gene Information Basic Information Ensembl ID: ENSMUSG00000024985 Description: transcription factor 7 like 2%2C T cell specific%2C HMG box [Source:MGI Symbol;Acc:MGI:1202879] Location: 19:55730252-55922086 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell fibroblast macrophage excitatory neuron mesenchymal cell oligodendrocyte Other: Signaling by WNT RNA Polymerase II Transcription MITF-M-regulated melanocyte development
MTOR signalling Pathway Hierarchies & Genes Energy dependent regulation of mTOR by LKB1-AMPK (2 genes) Signal Transduction MTOR signalling Inhibition of TSC complex formation by PKB Energy dependent regulation of mTOR by LKB1-AMPK 2 genes	Rragd Gene Information Basic Information Ensembl ID: ENSMUSG00000028278 Description: Ras-related GTP binding D [Source:MGI Symbol;Acc:MGI:1098604] Location: 4:32983037-33022180 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Macroautophagy MTOR signalling Cellular responses to stress Tsc1 Gene Information Basic Information Ensembl ID: ENSMUSG00000026812 Description: TSC complex subunit 1 [Source:MGI Symbol;Acc:MGI:1929183] Location: 2:28531240-28581179 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Macroautophagy MTOR signalling Membrane Trafficking
Macroautophagy Pathway Hierarchies & Genes PINK1-PRKN Mediated Mitophagy (3 genes) Autophagy Macroautophagy 2 genes Selective autophagy Mitophagy PINK1-PRKN Mediated Mitophagy 1 genes	Prkn Gene Information Basic Information Ensembl ID: ENSMUSG00000023826 Description: parkin RBR E3 ubiquitin protein ligase [Source:MGI Symbol;Acc:MGI:1355296] Location: 17:11059271-12282248 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Adaptive Immune System Macroautophagy Regulated Necrosis Rragd Gene Information Basic Information Ensembl ID: ENSMUSG00000028278 Description: Ras-related GTP binding D [Source:MGI Symbol;Acc:MGI:1098604] Location: 4:32983037-33022180 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Macroautophagy MTOR signalling Cellular responses to stress Tsc1 Gene Information Basic Information Ensembl ID: ENSMUSG00000026812 Description: TSC complex subunit 1 [Source:MGI Symbol;Acc:MGI:1929183] Location: 2:28531240-28581179 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Macroautophagy MTOR signalling Membrane Trafficking
Membrane Trafficking Pathway Hierarchies & Genes COPI-dependent Golgi-to-ER retrograde traffic (2 genes) Vesicle-mediated transport Membrane Trafficking ER to Golgi Anterograde Transport COPII-mediated vesicle transport 1 genes Intra-Golgi and retrograde Golgi-to-ER traffic Golgi-to-ER retrograde transport COPI-dependent Golgi-to-ER retrograde traffic 1 genes Cargo recognition for clathrin-mediated endocytosis (2 genes) Vesicle-mediated transport Membrane Trafficking trans-Golgi Network Vesicle Budding Lysosome Vesicle Biogenesis 1 genes Clathrin-mediated endocytosis Cargo recognition for clathrin-mediated endocytosis 1 genes Transport of connexons to the plasma membrane (1 genes) Vesicle-mediated transport Membrane Trafficking Gap junction trafficking and regulation Gap junction trafficking Gap junction assembly Transport of connexons to the plasma membrane 1 genes COPI-dependent Golgi-to-ER retrograde traffic (2 genes) Vesicle-mediated transport Membrane Trafficking Intra-Golgi and retrograde Golgi-to-ER traffic Golgi-to-ER retrograde transport COPI-dependent Golgi-to-ER retrograde traffic 2 genes COPI-independent Golgi-to-ER retrograde traffic (3 genes) Vesicle-mediated transport Membrane Trafficking Intra-Golgi and retrograde Golgi-to-ER traffic Golgi-to-ER retrograde transport COPI-independent Golgi-to-ER retrograde traffic 3 genes Cargo recognition for clathrin-mediated endocytosis (9 genes) Vesicle-mediated transport Membrane Trafficking Clathrin-mediated endocytosis Cargo recognition for clathrin-mediated endocytosis 9 genes Golgi Associated Vesicle Biogenesis (1 genes) Vesicle-mediated transport Membrane Trafficking trans-Golgi Network Vesicle Budding Golgi Associated Vesicle Biogenesis 1 genes Regulation of gap junction activity (1 genes) Vesicle-mediated transport Membrane Trafficking Gap junction trafficking and regulation Regulation of gap junction activity 1 genes Retrograde transport at the Trans-Golgi-Network (1 genes) Vesicle-mediated transport Membrane Trafficking Intra-Golgi and retrograde Golgi-to-ER traffic Retrograde transport at the Trans-Golgi-Network 1 genes TBC/RABGAPs (1 genes) Vesicle-mediated transport Membrane Trafficking Rab regulation of trafficking TBC/RABGAPs 1 genes Clathrin-mediated endocytosis (2 genes) Vesicle-mediated transport Membrane Trafficking Clathrin-mediated endocytosis 2 genes	Adrb2 Gene Information Basic Information Ensembl ID: ENSMUSG00000045730 Description: adrenergic receptor%2C beta 2 [Source:MGI Symbol;Acc:MGI:87938] Location: 18:62310887-62313030 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: smooth muscle cell erythroblast Other: Membrane Trafficking Signaling by GPCR Post-translational protein modification Ap1s3 Gene Information Basic Information Ensembl ID: ENSMUSG00000054702 Description: adaptor-related protein complex AP-1%2C sigma 3 [Source:MGI Symbol;Acc:MGI:1891304] Location: 1:79584593-79649689 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell intercalated cell mast cell dendritic cell Other: Adaptive Immune System Membrane Trafficking Arrb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000018909 Description: arrestin%2C beta 1 [Source:MGI Symbol;Acc:MGI:99473] Location: 7:99184673-99255978 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stromal cell Other: Membrane Trafficking Signaling by GPCR Signaling by Hedgehog Arrb2 Gene Information Basic Information Ensembl ID: ENSMUSG00000060216 Description: arrestin%2C beta 2 [Source:MGI Symbol;Acc:MGI:99474] Location: 11:70323461-70331654 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell antigen presenting cell Other: Signaling by WNT Membrane Trafficking Signaling by GPCR Bicd1 Gene Information Basic Information Ensembl ID: ENSMUSG00000003452 Description: BICD cargo adaptor 1 [Source:MGI Symbol;Acc:MGI:1101760] Location: 6:149310384-149464827 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast epithelial cell neuron Other: Membrane Trafficking Dnm3 Gene Information Basic Information Ensembl ID: ENSMUSG00000040265 Description: dynamin 3 [Source:MGI Symbol;Acc:MGI:1341299] Location: 1:161810022-162305603 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Adaptive Immune System Innate Immune System Membrane Trafficking Dvl2 Gene Information Basic Information Ensembl ID: ENSMUSG00000020888 Description: dishevelled segment polarity protein 2 [Source:MGI Symbol;Acc:MGI:106613] Location: 11:69891421-69903127 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by Hippo Membrane Trafficking Signaling by WNT Fzd4 Gene Information Basic Information Ensembl ID: ENSMUSG00000049791 Description: frizzled class receptor 4 [Source:MGI Symbol;Acc:MGI:108520] Location: 7:89053563-89062342 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Signaling by WNT Membrane Trafficking Gjb2 Gene Information Basic Information Ensembl ID: ENSMUSG00000046352 Description: gap junction protein%2C beta 2 [Source:MGI Symbol;Acc:MGI:95720] Location: 14:57336057-57342159 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stem cell fibroblast Other: Membrane Trafficking Gria1 Gene Information Basic Information Ensembl ID: ENSMUSG00000020524 Description: glutamate receptor%2C ionotropic%2C AMPA1 (alpha 1) [Source:MGI Symbol;Acc:MGI:95808] Location: 11:56902213-57221070 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: bergmann glial cell neuron Other: Transmission across Chemical Synapses Membrane Trafficking Post-translational protein modification Grk2 Gene Information Basic Information Ensembl ID: ENSMUSG00000024858 Description: G protein-coupled receptor kinase 2 [Source:MGI Symbol;Acc:MGI:87940] Location: 19:4336029-4356250 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Membrane Trafficking Signaling by GPCR Signaling by Hedgehog Grk3 Gene Information Basic Information Ensembl ID: ENSMUSG00000042249 Description: G protein-coupled receptor kinase 3 [Source:MGI Symbol;Acc:MGI:87941] Location: 5:113058348-113163657 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: bone cell monocyte dendritic cell Other: Membrane Trafficking Signaling by GPCR Il7r Gene Information Basic Information Ensembl ID: ENSMUSG00000003882 Description: interleukin 7 receptor [Source:MGI Symbol;Acc:MGI:96562] Location: 15:9505874-9530262 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell CD8+ T cell dendritic cell developing T cell Regulatory T cell mast cell memory T cell effector T cell innate lymphoid cell Other: Cytokine Signaling in Immune system Membrane Trafficking Kif16b Gene Information Basic Information Ensembl ID: ENSMUSG00000038844 Description: kinesin family member 16B [Source:MGI Symbol;Acc:MGI:1098240] Location: 2:142459394-142743451 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Adaptive Immune System Membrane Trafficking Factors involved in megakaryocyte development and platelet production Nsf Gene Information Basic Information Ensembl ID: ENSMUSG00000034187 Description: N-ethylmaleimide sensitive fusion protein [Source:MGI Symbol;Acc:MGI:104560] Location: 11:103712608-103844882 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron epithelial cell Naive B cell Other: Transmission across Chemical Synapses Membrane Trafficking Post-translational protein modification Pacsin1 Gene Information Basic Information Ensembl ID: ENSMUSG00000040276 Description: protein kinase C and casein kinase substrate in neurons 1 [Source:MGI Symbol;Acc:MGI:1345181] Location: 17:27874483-27930456 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Specialized T cell dendritic cell myeloid progenitor cell Other: Membrane Trafficking Pla2g4a Gene Information Basic Information Ensembl ID: ENSMUSG00000056220 Description: phospholipase A2%2C group IVA (cytosolic%2C calcium-dependent) [Source:MGI Symbol;Acc:MGI:1195256] Location: 1:149705369-149837041 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Membrane Trafficking Signaling by GPCR Platelet homeostasis Pla2g6 Gene Information Basic Information Ensembl ID: ENSMUSG00000042632 Description: phospholipase A2%2C group VI [Source:MGI Symbol;Acc:MGI:1859152] Location: 15:79170428-79212590 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Membrane Trafficking Metabolism of lipids Plin3 Gene Information Basic Information Ensembl ID: ENSMUSG00000024197 Description: perilipin 3 [Source:MGI Symbol;Acc:MGI:1914155] Location: 17:56584476-56599873 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: lymphoid progenitor cell Other: Membrane Trafficking Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Sh3gl1 Gene Information Basic Information Ensembl ID: ENSMUSG00000003200 Description: SH3-domain GRB2-like 1 [Source:MGI Symbol;Acc:MGI:700010] Location: 17:56323750-56343635 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Membrane Trafficking Signaling by Receptor Tyrosine Kinases Sort1 Gene Information Basic Information Ensembl ID: ENSMUSG00000068747 Description: sortilin 1 [Source:MGI Symbol;Acc:MGI:1338015] Location: 3:108191398-108268827 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: macrophage Other: Membrane Trafficking Tjp1 Gene Information Basic Information Ensembl ID: ENSMUSG00000030516 Description: tight junction protein 1 [Source:MGI Symbol;Acc:MGI:98759] Location: 7:64945913-65177529 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell epithelial cell Other: Apoptosis Membrane Trafficking Signaling by Hippo Tsc1 Gene Information Basic Information Ensembl ID: ENSMUSG00000026812 Description: TSC complex subunit 1 [Source:MGI Symbol;Acc:MGI:1929183] Location: 2:28531240-28581179 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Macroautophagy MTOR signalling Membrane Trafficking Wnt5a Gene Information Basic Information Ensembl ID: ENSMUSG00000021994 Description: wingless-type MMTV integration site family%2C member 5A [Source:MGI Symbol;Acc:MGI:98958] Location: 14:28226707-28249405 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: smooth muscle cell ectodermal cell epithelial cell Other: Membrane Trafficking Signaling by WNT Zw10 Gene Information Basic Information Ensembl ID: ENSMUSG00000032264 Description: zw10 kinetochore protein [Source:MGI Symbol;Acc:MGI:1349478] Location: 9:48966913-48990075 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Membrane Trafficking Cell Cycle, Mitotic Cell Cycle Checkpoints
Metabolism of amino acids and derivatives Pathway Hierarchies & Genes Phenylalanine metabolism (1 genes) Metabolism Metabolism of amino acids and derivatives Phenylalanine and tyrosine metabolism Phenylalanine metabolism 1 genes Histidine catabolism (1 genes) Metabolism Metabolism of amino acids and derivatives Histidine catabolism 1 genes Metabolism of polyamines (1 genes) Metabolism Metabolism of amino acids and derivatives Metabolism of polyamines 1 genes Urea cycle (1 genes) Metabolism Metabolism of amino acids and derivatives Urea cycle 1 genes	Arg2 Gene Information Basic Information Ensembl ID: ENSMUSG00000021125 Description: arginase type II [Source:MGI Symbol;Acc:MGI:1330806] Location: 12:79177551-79203075 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: enterocyte Other: Metabolism of amino acids and derivatives Mitochondrial protein degradation Hdc Gene Information Basic Information Ensembl ID: ENSMUSG00000027360 Description: histidine decarboxylase [Source:MGI Symbol;Acc:MGI:96062] Location: 2:126435587-126461219 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell natural killer cell epithelial cell mast cell granulocyte eosinophil myeloid cell modulatory neuron Other: Metabolism of amino acids and derivatives Il4i1 Gene Information Basic Information Ensembl ID: ENSMUSG00000074141 Description: interleukin 4 induced 1 [Source:MGI Symbol;Acc:MGI:109552] Location: 7:44465811-44490233 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell Other: Metabolism of amino acids and derivatives Sms Gene Information Basic Information Ensembl ID: ENSMUSG00000071708 Description: spermine synthase [Source:MGI Symbol;Acc:MGI:109490] Location: X:156226851-156275283 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell Other: Metabolism of amino acids and derivatives
Metabolism of carbohydrates and carbohydrate derivatives Pathway Hierarchies & Genes HS-GAG biosynthesis (6 genes) Metabolism Metabolism of carbohydrates and carbohydrate derivatives Glycosaminoglycan metabolism Heparan sulfate/heparin (HS-GAG) metabolism HS-GAG biosynthesis 6 genes Hyaluronan degradation (2 genes) Metabolism Metabolism of carbohydrates and carbohydrate derivatives Glycosaminoglycan metabolism Hyaluronan metabolism Hyaluronan degradation 2 genes Keratan sulfate biosynthesis (2 genes) Metabolism Metabolism of carbohydrates and carbohydrate derivatives Glycosaminoglycan metabolism Keratan sulfate/keratin metabolism Keratan sulfate biosynthesis 2 genes Regulation of Glucokinase by Glucokinase Regulatory Protein (1 genes) Metabolism Metabolism of carbohydrates and carbohydrate derivatives Glucose metabolism Glycolysis Regulation of Glucokinase by Glucokinase Regulatory Protein 1 genes Hyaluronan metabolism (1 genes) Metabolism Metabolism of carbohydrates and carbohydrate derivatives Glycosaminoglycan metabolism Hyaluronan metabolism 1 genes Formation of xylulose-5-phosphate (1 genes) Metabolism Metabolism of carbohydrates and carbohydrate derivatives Formation of xylulose-5-phosphate 1 genes Galactose catabolism (1 genes) Metabolism Metabolism of carbohydrates and carbohydrate derivatives Galactose catabolism 1 genes Lactose synthesis (1 genes) Metabolism Metabolism of carbohydrates and carbohydrate derivatives Lactose synthesis 1 genes Pentose phosphate pathway (1 genes) Metabolism Metabolism of carbohydrates and carbohydrate derivatives Pentose phosphate pathway 1 genes	Abcc5 Gene Information Basic Information Ensembl ID: ENSMUSG00000022822 Description: ATP-binding cassette%2C sub-family C member 5 [Source:MGI Symbol;Acc:MGI:1351644] Location: 16:20150053-20245144 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: embryonic cell Other: ABC-family proteins mediated transport Metabolism of carbohydrates and carbohydrate derivatives Azathioprine ADME Cd44 Gene Information Basic Information Ensembl ID: ENSMUSG00000005087 Description: CD44 antigen [Source:MGI Symbol;Acc:MGI:88338] Location: 2:102641486-102732010 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell phagocyte monocyte granulocyte neutrophil macrophage progenitor cell Other: Cell surface interactions at the vascular wall Integrin cell surface interactions Innate Immune System Chst1 Gene Information Basic Information Ensembl ID: ENSMUSG00000027221 Description: carbohydrate sulfotransferase 1 [Source:MGI Symbol;Acc:MGI:1924219] Location: 2:92430052-92445595 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Naive B cell plasma cell Other: Metabolism of carbohydrates and carbohydrate derivatives Cryl1 Gene Information Basic Information Ensembl ID: ENSMUSG00000021947 Description: crystallin%2C lambda 1 [Source:MGI Symbol;Acc:MGI:1915881] Location: 14:57512450-57635986 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Metabolism of carbohydrates and carbohydrate derivatives Dera Gene Information Basic Information Ensembl ID: ENSMUSG00000030225 Description: deoxyribose-phosphate aldolase [Source:MGI Symbol;Acc:MGI:1913762] Location: 6:137731544-137834338 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Metabolism of carbohydrates and carbohydrate derivatives Ext1 Gene Information Basic Information Ensembl ID: ENSMUSG00000061731 Description: exostosin glycosyltransferase 1 [Source:MGI Symbol;Acc:MGI:894663] Location: 15:52927434-53209555 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell glial cell bone cell mast cell antigen presenting cell Other: Metabolism of carbohydrates and carbohydrate derivatives Ext2 Gene Information Basic Information Ensembl ID: ENSMUSG00000027198 Description: exostosin glycosyltransferase 2 [Source:MGI Symbol;Acc:MGI:108050] Location: 2:93491373-93652913 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Metabolism of carbohydrates and carbohydrate derivatives Galk1 Gene Information Basic Information Ensembl ID: ENSMUSG00000020766 Description: galactokinase 1 [Source:MGI Symbol;Acc:MGI:95730] Location: 11:115899283-115903545 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: tuft cell Other: Metabolism of carbohydrates and carbohydrate derivatives Gpc1 Gene Information Basic Information Ensembl ID: ENSMUSG00000034220 Description: glypican 1 [Source:MGI Symbol;Acc:MGI:1194891] Location: 1:92759367-92788501 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: glial cell podocyte Other: Metabolism of vitamins and cofactors Cell surface interactions at the vascular wall Visual phototransduction Gpc3 Gene Information Basic Information Ensembl ID: ENSMUSG00000055653 Description: glypican 3 [Source:MGI Symbol;Acc:MGI:104903] Location: X:51361303-51702827 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell stromal cell embryonic cell fibroblast epithelial cell Other: Metabolism of vitamins and cofactors Visual phototransduction Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Hs3st1 Gene Information Basic Information Ensembl ID: ENSMUSG00000051022 Description: heparan sulfate (glucosamine) 3-O-sulfotransferase 1 [Source:MGI Symbol;Acc:MGI:1201606] Location: 5:39771278-39912818 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell natural killer cell mast cell smooth muscle cell Other: Metabolism of carbohydrates and carbohydrate derivatives Hyal2 Gene Information Basic Information Ensembl ID: ENSMUSG00000010047 Description: hyaluronoglucosaminidase 2 [Source:MGI Symbol;Acc:MGI:1196334] Location: 9:107445144-107449978 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell smooth muscle cell Other: Metabolism of carbohydrates and carbohydrate derivatives Lum Gene Information Basic Information Ensembl ID: ENSMUSG00000036446 Description: lumican [Source:MGI Symbol;Acc:MGI:109347] Location: 10:97400990-97408565 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stellate cell stem cell stromal cell epithelial cell Other: Integrin cell surface interactions Metabolism of carbohydrates and carbohydrate derivatives Nup85 Gene Information Basic Information Ensembl ID: ENSMUSG00000020739 Description: nucleoporin 85 [Source:MGI Symbol;Acc:MGI:3046173] Location: 11:115455260-115474811 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: bone cell Other: Metabolism of non-coding RNA Gene Silencing by RNA Cellular responses to stress Sdc2 Gene Information Basic Information Ensembl ID: ENSMUSG00000022261 Description: syndecan 2 [Source:MGI Symbol;Acc:MGI:1349165] Location: 15:32920869-33035081 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte osteoblast mural cell Other: Metabolism of vitamins and cofactors Cell surface interactions at the vascular wall Visual phototransduction Slc2a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000028645 Description: solute carrier family 2 (facilitated glucose transporter)%2C member 1 [Source:MGI Symbol;Acc:MGI:95755] Location: 4:118965908-118995180 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell epithelial cell Other: Integration of energy metabolism Metabolism of vitamins and cofactors SLC-mediated transmembrane transport
Metabolism of lipids Pathway Hierarchies & Genes Biosynthesis of DPAn-3-derived protectins and resolvins (1 genes) Metabolism Metabolism of lipids Fatty acid metabolism Arachidonate metabolism Synthesis of Leukotrienes (LT) and Eoxins (EX) Biosynthesis of specialized proresolving mediators (SPMs) Biosynthesis of DPA-derived SPMs Biosynthesis of DPAn-3 SPMs Biosynthesis of DPAn-3-derived protectins and resolvins 1 genes Biosynthesis of DPAn-3 SPMs (1 genes) Metabolism Metabolism of lipids Fatty acid metabolism Arachidonate metabolism Synthesis of 15-eicosatetraenoic acid derivatives Biosynthesis of specialized proresolving mediators (SPMs) Biosynthesis of DPA-derived SPMs Biosynthesis of DPAn-3 SPMs 1 genes Arachidonate metabolism (9 genes) Metabolism Metabolism of lipids Phospholipid metabolism Glycerophospholipid biosynthesis Acyl chain remodelling of PC 8 genes Fatty acid metabolism Arachidonate metabolism 1 genes Synthesis of Leukotrienes (LT) and Eoxins (EX) (2 genes) Metabolism Metabolism of lipids Sphingolipid metabolism Sphingolipid de novo biosynthesis 1 genes Fatty acid metabolism Arachidonate metabolism Synthesis of Leukotrienes (LT) and Eoxins (EX) 1 genes Triglyceride biosynthesis (2 genes) Metabolism Metabolism of lipids Phospholipid metabolism Glycerophospholipid biosynthesis Acyl chain remodeling of DAG and TAG Triglyceride metabolism Triglyceride biosynthesis 2 genes Cholesterol biosynthesis via lathosterol (3 genes) Metabolism Metabolism of lipids Metabolism of steroids Cholesterol biosynthesis Cholesterol biosynthesis via lathosterol 3 genes Glycosphingolipid biosynthesis (1 genes) Metabolism Metabolism of lipids Sphingolipid metabolism Glycosphingolipid metabolism Glycosphingolipid biosynthesis 1 genes Glycosphingolipid catabolism (3 genes) Metabolism Metabolism of lipids Sphingolipid metabolism Glycosphingolipid metabolism Glycosphingolipid catabolism 3 genes Hydrolysis of LPC (1 genes) Metabolism Metabolism of lipids Phospholipid metabolism Glycerophospholipid biosynthesis Hydrolysis of LPC 1 genes Linoleic acid (LA) metabolism (1 genes) Metabolism Metabolism of lipids Fatty acid metabolism alpha-linolenic (omega3) and linoleic (omega6) acid metabolism Linoleic acid (LA) metabolism 1 genes Recycling of bile acids and salts (1 genes) Metabolism Metabolism of lipids Metabolism of steroids Bile acid and bile salt metabolism Recycling of bile acids and salts 1 genes Synthesis of PA (2 genes) Metabolism Metabolism of lipids Phospholipid metabolism Glycerophospholipid biosynthesis Synthesis of PA 2 genes Synthesis of PC (2 genes) Metabolism Metabolism of lipids Phospholipid metabolism Glycerophospholipid biosynthesis Synthesis of PC 2 genes Synthesis of PI (1 genes) Metabolism Metabolism of lipids Phospholipid metabolism Glycerophospholipid biosynthesis Synthesis of PI 1 genes Synthesis of PIPs at the Golgi membrane (1 genes) Metabolism Metabolism of lipids Phospholipid metabolism PI Metabolism Synthesis of PIPs at the Golgi membrane 1 genes Synthesis of PIPs at the plasma membrane (1 genes) Metabolism Metabolism of lipids Phospholipid metabolism PI Metabolism Synthesis of PIPs at the plasma membrane 1 genes Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (3 genes) Metabolism Metabolism of lipids Fatty acid metabolism Arachidonate metabolism Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 3 genes Synthesis of bile acids and bile salts (2 genes) Metabolism Metabolism of lipids Metabolism of steroids Bile acid and bile salt metabolism Synthesis of bile acids and bile salts 2 genes Synthesis of very long-chain fatty acyl-CoAs (1 genes) Metabolism Metabolism of lipids Fatty acid metabolism Fatty acyl-CoA biosynthesis Synthesis of very long-chain fatty acyl-CoAs 1 genes Carnitine shuttle (3 genes) Metabolism Metabolism of lipids Fatty acid metabolism Carnitine shuttle 3 genes Cholesterol biosynthesis (1 genes) Metabolism Metabolism of lipids Metabolism of steroids Cholesterol biosynthesis 1 genes Glycerophospholipid biosynthesis (1 genes) Metabolism Metabolism of lipids Phospholipid metabolism Glycerophospholipid biosynthesis 1 genes Sphingolipid catabolism (1 genes) Metabolism Metabolism of lipids Sphingolipid metabolism Sphingolipid catabolism 1 genes Synthesis of Ketone Bodies (1 genes) Metabolism Metabolism of lipids Ketone body metabolism Synthesis of Ketone Bodies 1 genes Triglyceride catabolism (2 genes) Metabolism Metabolism of lipids Triglyceride metabolism Triglyceride catabolism 2 genes Utilization of Ketone Bodies (1 genes) Metabolism Metabolism of lipids Ketone body metabolism Utilization of Ketone Bodies 1 genes Regulation of lipid metabolism by PPARalpha (1 genes) Metabolism Metabolism of lipids Regulation of lipid metabolism by PPARalpha 1 genes	Abcc1 Gene Information Basic Information Ensembl ID: ENSMUSG00000023088 Description: ATP-binding cassette%2C sub-family C member 1 [Source:MGI Symbol;Acc:MGI:102676] Location: 16:14179422-14293601 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: ABC-family proteins mediated transport Metabolism of porphyrins Metabolism of vitamins and cofactors Abcc3 Gene Information Basic Information Ensembl ID: ENSMUSG00000020865 Description: ATP-binding cassette%2C sub-family C member 3 [Source:MGI Symbol;Acc:MGI:1923658] Location: 11:94234121-94283823 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Paracetamol ADME ABC-family proteins mediated transport Metabolism of lipids Abcd1 Gene Information Basic Information Ensembl ID: ENSMUSG00000031378 Description: ATP-binding cassette%2C sub-family D member 1 [Source:MGI Symbol;Acc:MGI:1349215] Location: X:72760203-72782140 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: ABC-family proteins mediated transport Metabolism of lipids Class I peroxisomal membrane protein import Acsl6 Gene Information Basic Information Ensembl ID: ENSMUSG00000020333 Description: acyl-CoA synthetase long-chain family member 6 [Source:MGI Symbol;Acc:MGI:894291] Location: 11:54194624-54255582 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Metabolism of lipids Alox15 Gene Information Basic Information Ensembl ID: ENSMUSG00000018924 Description: arachidonate 15-lipoxygenase [Source:MGI Symbol;Acc:MGI:87997] Location: 11:70234978-70242857 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: basophil Other: Metabolism of lipids Cpne1 Gene Information Basic Information Ensembl ID: ENSMUSG00000074643 Description: copine I [Source:MGI Symbol;Acc:MGI:2386621] Location: 2:155913762-155953885 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Metabolism of lipids Cpt1b Gene Information Basic Information Ensembl ID: ENSMUSG00000078937 Description: carnitine palmitoyltransferase 1b%2C muscle [Source:MGI Symbol;Acc:MGI:1098297] Location: 15:89300608-89310066 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Metabolism of lipids Dgat1 Gene Information Basic Information Ensembl ID: ENSMUSG00000022555 Description: diacylglycerol O-acyltransferase 1 [Source:MGI Symbol;Acc:MGI:1333825] Location: 15:76386215-76396153 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell developing T cell epithelial cell adipocyte hematopoietic stem cell mast cell Other: Innate Immune System Metabolism of lipids Dgat2 Gene Information Basic Information Ensembl ID: ENSMUSG00000030747 Description: diacylglycerol O-acyltransferase 2 [Source:MGI Symbol;Acc:MGI:1915050] Location: 7:98802865-98831926 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Metabolism of lipids Fabp12 Gene Information Basic Information Ensembl ID: ENSMUSG00000027530 Description: fatty acid binding protein 12 [Source:MGI Symbol;Acc:MGI:1922747] Location: 3:10309269-10366243 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: photoreceptor cell Other: Metabolism of lipids Fig4 Gene Information Basic Information Ensembl ID: ENSMUSG00000038417 Description: FIG4 phosphoinositide 5-phosphatase [Source:MGI Symbol;Acc:MGI:2143585] Location: 10:41064168-41179256 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Metabolism of lipids Gal3st1 Gene Information Basic Information Ensembl ID: ENSMUSG00000049721 Description: galactose-3-O-sulfotransferase 1 [Source:MGI Symbol;Acc:MGI:1858277] Location: 11:3933636-3949326 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Metabolism of lipids Gm2a Gene Information Basic Information Ensembl ID: ENSMUSG00000000594 Description: GM2 ganglioside activator protein [Source:MGI Symbol;Acc:MGI:95762] Location: 11:54988941-55003855 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Metabolism of lipids Gpat3 Gene Information Basic Information Ensembl ID: ENSMUSG00000029314 Description: glycerol-3-phosphate acyltransferase 3 [Source:MGI Symbol;Acc:MGI:3603816] Location: 5:100993579-101046968 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Metabolism of lipids Gpd1 Gene Information Basic Information Ensembl ID: ENSMUSG00000023019 Description: glycerol-3-phosphate dehydrogenase 1 (soluble) [Source:MGI Symbol;Acc:MGI:95679] Location: 15:99615396-99622886 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Metabolism of lipids Hmgcll1 Gene Information Basic Information Ensembl ID: ENSMUSG00000007908 Description: 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1 [Source:MGI Symbol;Acc:MGI:2446108] Location: 9:75922137-76043632 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Metabolism of lipids Hsd17b7 Gene Information Basic Information Ensembl ID: ENSMUSG00000026675 Description: hydroxysteroid (17-beta) dehydrogenase 7 [Source:MGI Symbol;Acc:MGI:1330808] Location: 1:169777104-169796810 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: leydig cell Other: Metabolism of lipids Inpp5k Gene Information Basic Information Ensembl ID: ENSMUSG00000006127 Description: inositol polyphosphate 5-phosphatase K [Source:MGI Symbol;Acc:MGI:1194899] Location: 11:75521814-75539697 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Metabolism of lipids Lpcat1 Gene Information Basic Information Ensembl ID: ENSMUSG00000021608 Description: lysophosphatidylcholine acyltransferase 1 [Source:MGI Symbol;Acc:MGI:2384812] Location: 13:73615316-73664541 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pneumocyte Other: Innate Immune System Metabolism of lipids Lpcat2 Gene Information Basic Information Ensembl ID: ENSMUSG00000033192 Description: lysophosphatidylcholine acyltransferase 2 [Source:MGI Symbol;Acc:MGI:3606214] Location: 8:93581967-93645907 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell phagocyte microglia macrophage Other: Metabolism of lipids Med1 Gene Information Basic Information Ensembl ID: ENSMUSG00000018160 Description: mediator complex subunit 1 [Source:MGI Symbol;Acc:MGI:1100846] Location: 11:98042980-98084119 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cellular responses to stress Metabolism of lipids RNA Polymerase II Transcription Mid1ip1 Gene Information Basic Information Ensembl ID: ENSMUSG00000008035 Description: Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish)) [Source:MGI Symbol;Acc:MGI:1915291] Location: X:10581252-10585929 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron schwann cell Other: Metabolism of lipids Nsdhl Gene Information Basic Information Ensembl ID: ENSMUSG00000031349 Description: NAD(P) dependent steroid dehydrogenase-like [Source:MGI Symbol;Acc:MGI:1099438] Location: X:71962163-72002120 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: leydig cell Other: Metabolism of lipids Osbpl2 Gene Information Basic Information Ensembl ID: ENSMUSG00000039050 Description: oxysterol binding protein-like 2 [Source:MGI Symbol;Acc:MGI:2442832] Location: 2:179761099-179804473 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Metabolism of lipids Osbpl3 Gene Information Basic Information Ensembl ID: ENSMUSG00000029822 Description: oxysterol binding protein-like 3 [Source:MGI Symbol;Acc:MGI:1918970] Location: 6:50270310-50433181 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell Specialized T cell Other: Metabolism of lipids Oxct1 Gene Information Basic Information Ensembl ID: ENSMUSG00000022186 Description: 3-oxoacid CoA transferase 1 [Source:MGI Symbol;Acc:MGI:1914291] Location: 15:4055865-4184826 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Metabolism of lipids Mitochondrial protein degradation Phospho1 Gene Information Basic Information Ensembl ID: ENSMUSG00000050860 Description: phosphatase%2C orphan 1 [Source:MGI Symbol;Acc:MGI:2447348] Location: 11:95715325-95722966 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: erythrocyte erythroblast Other: Metabolism of lipids Pitpnm1 Gene Information Basic Information Ensembl ID: ENSMUSG00000024851 Description: phosphatidylinositol transfer protein%2C membrane-associated 1 [Source:MGI Symbol;Acc:MGI:1197524] Location: 19:4149998-4163965 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Metabolism of lipids Pla2g12a Gene Information Basic Information Ensembl ID: ENSMUSG00000027999 Description: phospholipase A2%2C group XIIA [Source:MGI Symbol;Acc:MGI:1913600] Location: 3:129672255-129689474 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: hematopoietic progenitor cell Other: Metabolism of lipids Pla2g15 Gene Information Basic Information Ensembl ID: ENSMUSG00000031903 Description: phospholipase A2%2C group XV [Source:MGI Symbol;Acc:MGI:2178076] Location: 8:106877031-106891347 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Metabolism of lipids Pla2g2f Gene Information Basic Information Ensembl ID: ENSMUSG00000028749 Description: phospholipase A2%2C group IIF [Source:MGI Symbol;Acc:MGI:1349661] Location: 4:138477844-138484937 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Metabolism of lipids Pla2g3 Gene Information Basic Information Ensembl ID: ENSMUSG00000034579 Description: phospholipase A2%2C group III [Source:MGI Symbol;Acc:MGI:2444945] Location: 11:3438284-3449350 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: interneuron Other: Metabolism of lipids Pla2g4a Gene Information Basic Information Ensembl ID: ENSMUSG00000056220 Description: phospholipase A2%2C group IVA (cytosolic%2C calcium-dependent) [Source:MGI Symbol;Acc:MGI:1195256] Location: 1:149705369-149837041 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Membrane Trafficking Signaling by GPCR Platelet homeostasis Pla2g4f Gene Information Basic Information Ensembl ID: ENSMUSG00000046971 Description: phospholipase A2%2C group IVF [Source:MGI Symbol;Acc:MGI:2685493] Location: 2:120130438-120144646 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Metabolism of lipids Pla2g6 Gene Information Basic Information Ensembl ID: ENSMUSG00000042632 Description: phospholipase A2%2C group VI [Source:MGI Symbol;Acc:MGI:1859152] Location: 15:79170428-79212590 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Membrane Trafficking Metabolism of lipids Pla2r1 Gene Information Basic Information Ensembl ID: ENSMUSG00000054580 Description: phospholipase A2 receptor 1 [Source:MGI Symbol;Acc:MGI:102468] Location: 2:60247887-60383652 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Metabolism of lipids Plpp3 Gene Information Basic Information Ensembl ID: ENSMUSG00000028517 Description: phospholipid phosphatase 3 [Source:MGI Symbol;Acc:MGI:1915166] Location: 4:105014544-105089961 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: bergmann glial cell endothelial cell fibroblast stromal cell glial cell Other: Metabolism of lipids Pnpla5 Gene Information Basic Information Ensembl ID: ENSMUSG00000018868 Description: patatin-like phospholipase domain containing 5 [Source:MGI Symbol;Acc:MGI:1923022] Location: 15:83996557-84007376 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Metabolism of lipids Ppard Gene Information Basic Information Ensembl ID: ENSMUSG00000002250 Description: peroxisome proliferator activator receptor delta [Source:MGI Symbol;Acc:MGI:101884] Location: 17:28451674-28520448 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Metabolism of lipids RNA Polymerase II Transcription Signaling by Nuclear Receptors Ptges Gene Information Basic Information Ensembl ID: ENSMUSG00000050737 Description: prostaglandin E synthase [Source:MGI Symbol;Acc:MGI:1927593] Location: 2:30779483-30819875 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stromal cell Other: Metabolism of lipids Ptgs1 Gene Information Basic Information Ensembl ID: ENSMUSG00000047250 Description: prostaglandin-endoperoxide synthase 1 [Source:MGI Symbol;Acc:MGI:97797] Location: 2:36120438-36142284 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell phagocyte fibroblast microglia tuft cell epithelial cell Other: Biological oxidations Metabolism of lipids Ptgs2 Gene Information Basic Information Ensembl ID: ENSMUSG00000032487 Description: prostaglandin-endoperoxide synthase 2 [Source:MGI Symbol;Acc:MGI:97798] Location: 1:149975782-149983978 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell granulocyte tuft cell Other: Metabolism of lipids Slc44a2 Gene Information Basic Information Ensembl ID: ENSMUSG00000057193 Description: solute carrier family 44%2C member 2 [Source:MGI Symbol;Acc:MGI:1915932] Location: 9:21231994-21266324 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System SLC-mediated transmembrane transport Metabolism of lipids Smpd1 Gene Information Basic Information Ensembl ID: ENSMUSG00000037049 Description: sphingomyelin phosphodiesterase 1%2C acid lysosomal [Source:MGI Symbol;Acc:MGI:98325] Location: 7:105203567-105207596 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Metabolism of lipids Smpd3 Gene Information Basic Information Ensembl ID: ENSMUSG00000031906 Description: sphingomyelin phosphodiesterase 3%2C neutral [Source:MGI Symbol;Acc:MGI:1927578] Location: 8:106979180-107064620 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endocrine cell fibroblast osteoblast Other: Metabolism of lipids Death Receptor Signaling Sphk2 Gene Information Basic Information Ensembl ID: ENSMUSG00000057342 Description: sphingosine kinase 2 [Source:MGI Symbol;Acc:MGI:1861380] Location: 7:45358891-45367426 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Metabolism of lipids Sqle Gene Information Basic Information Ensembl ID: ENSMUSG00000022351 Description: squalene epoxidase [Source:MGI Symbol;Acc:MGI:109296] Location: 15:59186926-59203041 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: leydig cell Other: Metabolism of lipids Tbxas1 Gene Information Basic Information Ensembl ID: ENSMUSG00000029925 Description: thromboxane A synthase 1%2C platelet [Source:MGI Symbol;Acc:MGI:98497] Location: 6:38852338-39061519 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte Other: Biological oxidations Metabolism of lipids Tm7sf2 Gene Information Basic Information Ensembl ID: ENSMUSG00000024799 Description: transmembrane 7 superfamily member 2 [Source:MGI Symbol;Acc:MGI:1920416] Location: 19:6112851-6118403 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Metabolism of lipids
Metabolism of nitric oxide: NOS3 activation and regulation Pathway Hierarchies & Genes NOSTRIN mediated eNOS trafficking (1 genes) Metabolism Metabolism of nitric oxide: NOS3 activation and regulation eNOS activation NOSTRIN mediated eNOS trafficking 1 genes	Cav1 Gene Information Basic Information Ensembl ID: ENSMUSG00000007655 Description: caveolin 1%2C caveolae protein [Source:MGI Symbol;Acc:MGI:102709] Location: 6:17306334-17341451 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by WNT Metabolism of nitric oxide: NOS3 activation and regulation Cell surface interactions at the vascular wall
Metabolism of non-coding RNA Pathway Hierarchies & Genes snRNP Assembly (1 genes) Metabolism of RNA Metabolism of non-coding RNA snRNP Assembly 1 genes	Nup85 Gene Information Basic Information Ensembl ID: ENSMUSG00000020739 Description: nucleoporin 85 [Source:MGI Symbol;Acc:MGI:3046173] Location: 11:115455260-115474811 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: bone cell Other: Metabolism of non-coding RNA Gene Silencing by RNA Cellular responses to stress
Metabolism of nucleotides Pathway Hierarchies & Genes Purine ribonucleoside monophosphate biosynthesis (1 genes) Metabolism Metabolism of nucleotides Nucleotide biosynthesis Purine ribonucleoside monophosphate biosynthesis 1 genes Pyrimidine catabolism (2 genes) Metabolism Metabolism of nucleotides Nucleotide catabolism Pyrimidine catabolism 2 genes Interconversion of nucleotide di- and triphosphates (1 genes) Metabolism Metabolism of nucleotides Interconversion of nucleotide di- and triphosphates 1 genes	Adss1 Gene Information Basic Information Ensembl ID: ENSMUSG00000011148 Description: adenylosuccinate synthase 1 [Source:MGI Symbol;Acc:MGI:87947] Location: 12:112586479-112607794 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: bone cell monocyte Other: Metabolism of nucleotides Dpyd Gene Information Basic Information Ensembl ID: ENSMUSG00000033308 Description: dihydropyrimidine dehydrogenase [Source:MGI Symbol;Acc:MGI:2139667] Location: 3:118355778-119226573 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: adipocyte glial cell motor neuron mesenchymal cell Other: Metabolism of nucleotides Gsr Gene Information Basic Information Ensembl ID: ENSMUSG00000031584 Description: glutathione reductase [Source:MGI Symbol;Acc:MGI:95804] Location: 8:34142551-34188191 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: myeloid cell neutrophil myeloid derived suppressor cell immune cell Other: Metabolism of nucleotides Cellular responses to stress RNA Polymerase II Transcription Upb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000033427 Description: ureidopropionase%2C beta [Source:MGI Symbol;Acc:MGI:2143535] Location: 10:75236949-75277513 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell myeloid progenitor cell Other: Metabolism of nucleotides
Metabolism of porphyrins Pathway Hierarchies & Genes Heme degradation (1 genes) Metabolism Metabolism of porphyrins Heme degradation 1 genes	Abcc1 Gene Information Basic Information Ensembl ID: ENSMUSG00000023088 Description: ATP-binding cassette%2C sub-family C member 1 [Source:MGI Symbol;Acc:MGI:102676] Location: 16:14179422-14293601 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: ABC-family proteins mediated transport Metabolism of porphyrins Metabolism of vitamins and cofactors
Metabolism of vitamins and cofactors Pathway Hierarchies & Genes Coenzyme A biosynthesis (1 genes) Metabolism Metabolism of vitamins and cofactors Metabolism of water-soluble vitamins and cofactors Vitamin B5 (pantothenate) metabolism Coenzyme A biosynthesis 1 genes Transport of RCbl within the body (1 genes) Metabolism Metabolism of vitamins and cofactors Metabolism of water-soluble vitamins and cofactors Cobalamin (Cbl, vitamin B12) transport and metabolism Transport of RCbl within the body 1 genes Uptake of dietary cobalamins into enterocytes (1 genes) Metabolism Metabolism of vitamins and cofactors Metabolism of water-soluble vitamins and cofactors Cobalamin (Cbl, vitamin B12) transport and metabolism Uptake of dietary cobalamins into enterocytes 1 genes Nicotinate metabolism (1 genes) Metabolism Metabolism of vitamins and cofactors Metabolism of water-soluble vitamins and cofactors Nicotinate metabolism 1 genes Vitamin B2 (riboflavin) metabolism (1 genes) Metabolism Metabolism of vitamins and cofactors Metabolism of water-soluble vitamins and cofactors Vitamin B2 (riboflavin) metabolism 1 genes Vitamin B5 (pantothenate) metabolism (2 genes) Metabolism Metabolism of vitamins and cofactors Metabolism of water-soluble vitamins and cofactors Vitamin B5 (pantothenate) metabolism 2 genes Vitamin B6 activation to pyridoxal phosphate (1 genes) Metabolism Metabolism of vitamins and cofactors Metabolism of water-soluble vitamins and cofactors Vitamin B6 activation to pyridoxal phosphate 1 genes Vitamin C (ascorbate) metabolism (1 genes) Metabolism Metabolism of vitamins and cofactors Metabolism of water-soluble vitamins and cofactors Vitamin C (ascorbate) metabolism 1 genes Metabolism of fat-soluble vitamins (5 genes) Metabolism Metabolism of vitamins and cofactors Metabolism of fat-soluble vitamins 5 genes	Abcc1 Gene Information Basic Information Ensembl ID: ENSMUSG00000023088 Description: ATP-binding cassette%2C sub-family C member 1 [Source:MGI Symbol;Acc:MGI:102676] Location: 16:14179422-14293601 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: ABC-family proteins mediated transport Metabolism of porphyrins Metabolism of vitamins and cofactors Abcd4 Gene Information Basic Information Ensembl ID: ENSMUSG00000021240 Description: ATP-binding cassette%2C sub-family D member 4 [Source:MGI Symbol;Acc:MGI:1349217] Location: 12:84648238-84664187 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Metabolism of vitamins and cofactors Enpp1 Gene Information Basic Information Ensembl ID: ENSMUSG00000037370 Description: ectonucleotide pyrophosphatase/phosphodiesterase 1 [Source:MGI Symbol;Acc:MGI:97370] Location: 10:24513812-24588057 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Metabolism of vitamins and cofactors Gpc1 Gene Information Basic Information Ensembl ID: ENSMUSG00000034220 Description: glypican 1 [Source:MGI Symbol;Acc:MGI:1194891] Location: 1:92759367-92788501 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: glial cell podocyte Other: Metabolism of vitamins and cofactors Cell surface interactions at the vascular wall Visual phototransduction Gpc3 Gene Information Basic Information Ensembl ID: ENSMUSG00000055653 Description: glypican 3 [Source:MGI Symbol;Acc:MGI:104903] Location: X:51361303-51702827 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell stromal cell embryonic cell fibroblast epithelial cell Other: Metabolism of vitamins and cofactors Visual phototransduction Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Lpl Gene Information Basic Information Ensembl ID: ENSMUSG00000015568 Description: lipoprotein lipase [Source:MGI Symbol;Acc:MGI:96820] Location: 8:69333143-69360100 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: preadipocyte phagocyte fibroblast epithelial cell stromal cell erythrocyte dendritic cell macrophage endothelial cell antigen presenting cell adipocyte Other: Plasma lipoprotein assembly, remodeling, and clearance Metabolism of vitamins and cofactors Visual phototransduction Pank1 Gene Information Basic Information Ensembl ID: ENSMUSG00000033610 Description: pantothenate kinase 1 [Source:MGI Symbol;Acc:MGI:1922985] Location: 19:34784340-34856855 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: adipocyte stromal cell Other: Metabolism of vitamins and cofactors Pdxk Gene Information Basic Information Ensembl ID: ENSMUSG00000032788 Description: pyridoxal (pyridoxine%2C vitamin B6) kinase [Source:MGI Symbol;Acc:MGI:1351869] Location: 10:78272578-78300809 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Metabolism of vitamins and cofactors Rbp1 Gene Information Basic Information Ensembl ID: ENSMUSG00000046402 Description: retinol binding protein 1%2C cellular [Source:MGI Symbol;Acc:MGI:97876] Location: 9:98305014-98328628 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell fibroblast stellate cell stem cell glial cell epithelial cell Other: Metabolism of vitamins and cofactors Visual phototransduction Sdc2 Gene Information Basic Information Ensembl ID: ENSMUSG00000022261 Description: syndecan 2 [Source:MGI Symbol;Acc:MGI:1349165] Location: 15:32920869-33035081 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte osteoblast mural cell Other: Metabolism of vitamins and cofactors Cell surface interactions at the vascular wall Visual phototransduction Slc25a16 Gene Information Basic Information Ensembl ID: ENSMUSG00000071253 Description: solute carrier family 25 (mitochondrial carrier%2C Graves disease autoantigen)%2C member 16 [Source:MGI Symbol;Acc:MGI:1920382] Location: 10:62756412-62782277 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Metabolism of vitamins and cofactors Slc2a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000028645 Description: solute carrier family 2 (facilitated glucose transporter)%2C member 1 [Source:MGI Symbol;Acc:MGI:95755] Location: 4:118965908-118995180 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell epithelial cell Other: Integration of energy metabolism Metabolism of vitamins and cofactors SLC-mediated transmembrane transport Slc5a8 Gene Information Basic Information Ensembl ID: ENSMUSG00000020062 Description: solute carrier family 5 (iodide transporter)%2C member 8 [Source:MGI Symbol;Acc:MGI:2384916] Location: 10:88721854-88765377 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Metabolism of vitamins and cofactors SLC-mediated transmembrane transport Vnn1 Gene Information Basic Information Ensembl ID: ENSMUSG00000037440 Description: vanin 1 [Source:MGI Symbol;Acc:MGI:108395] Location: 10:23770586-23781241 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Metabolism of vitamins and cofactors Post-translational protein modification
Miscellaneous transport and binding events Pathway Hierarchies & Genes Miscellaneous transport and binding events (1 genes) Transport of small molecules Miscellaneous transport and binding events 1 genes	Nipal1 Gene Information Basic Information Ensembl ID: ENSMUSG00000067219 Description: NIPA-like domain containing 1 [Source:MGI Symbol;Acc:MGI:1917951] Location: 5:72805138-72828421 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Miscellaneous transport and binding events
Mitochondrial biogenesis Pathway Hierarchies & Genes Transcriptional activation of mitochondrial biogenesis (1 genes) Organelle biogenesis and maintenance Mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis 1 genes	Sirt5 Gene Information Basic Information Ensembl ID: ENSMUSG00000054021 Description: sirtuin 5 [Source:MGI Symbol;Acc:MGI:1915596] Location: 13:43518972-43548679 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Mitochondrial biogenesis
Mitochondrial protein degradation Pathway Hierarchies & Genes Mitochondrial protein degradation (2 genes) Metabolism of proteins Mitochondrial protein degradation 2 genes	Arg2 Gene Information Basic Information Ensembl ID: ENSMUSG00000021125 Description: arginase type II [Source:MGI Symbol;Acc:MGI:1330806] Location: 12:79177551-79203075 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: enterocyte Other: Metabolism of amino acids and derivatives Mitochondrial protein degradation Oxct1 Gene Information Basic Information Ensembl ID: ENSMUSG00000022186 Description: 3-oxoacid CoA transferase 1 [Source:MGI Symbol;Acc:MGI:1914291] Location: 15:4055865-4184826 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Metabolism of lipids Mitochondrial protein degradation
Myogenesis Pathway Hierarchies & Genes Myogenesis (7 genes) Developmental Biology Myogenesis 7 genes	Abl1 Gene Information Basic Information Ensembl ID: ENSMUSG00000026842 Description: c-abl oncogene 1%2C non-receptor tyrosine kinase [Source:MGI Symbol;Acc:MGI:87859] Location: 2:31578388-31694239 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Epigenetic regulation of gene expression Myogenesis Cdc42 Gene Information Basic Information Ensembl ID: ENSMUSG00000006699 Description: cell division cycle 42 [Source:MGI Symbol;Acc:MGI:106211] Location: 4:137047007-137085031 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: hematopoietic stem cell phagocyte antigen presenting cell macrophage dendritic cell Other: Adaptive Immune System Innate Immune System Signaling by GPCR Cdh2 Gene Information Basic Information Ensembl ID: ENSMUSG00000024304 Description: cadherin 2 [Source:MGI Symbol;Acc:MGI:88355] Location: 18:16721934-16942303 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte stellate cell glial cell skeletal muscle cell motor neuron osteoblast epithelial cell Other: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cell junction organization Myogenesis Cdh4 Gene Information Basic Information Ensembl ID: ENSMUSG00000000305 Description: cadherin 4 [Source:MGI Symbol;Acc:MGI:99218] Location: 2:179084224-179541166 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: bergmann glial cell epithelial cell retina cell Other: Cell junction organization Myogenesis Cdon Gene Information Basic Information Ensembl ID: ENSMUSG00000038119 Description: cell adhesion molecule-related/down-regulated by oncogenes [Source:MGI Symbol;Acc:MGI:1926387] Location: 9:35332424-35418948 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stem cell epithelial cell glial cell Other: Myogenesis Signaling by Hedgehog Ctnna1 Gene Information Basic Information Ensembl ID: ENSMUSG00000037815 Description: catenin alpha 1 [Source:MGI Symbol;Acc:MGI:88274] Location: 18:35251912-35387832 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Cell junction organization Myogenesis Signaling by Receptor Tyrosine Kinases Ctnnb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000006932 Description: catenin beta 1 [Source:MGI Symbol;Acc:MGI:88276] Location: 9:120758282-120789573 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stem cell epithelial cell Other: Apoptosis Innate Immune System Signaling by WNT
Nephrin family interactions Pathway Hierarchies & Genes Nephrin family interactions (3 genes) Cell-Cell communication Nephrin family interactions 3 genes	Fyn Gene Information Basic Information Ensembl ID: ENSMUSG00000019843 Description: Fyn proto-oncogene [Source:MGI Symbol;Acc:MGI:95602] Location: 10:39244851-39441377 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cell surface interactions at the vascular wall Nephrin family interactions Cytokine Signaling in Immune system Iqgap1 Gene Information Basic Information Ensembl ID: ENSMUSG00000030536 Description: IQ motif containing GTPase activating protein 1 [Source:MGI Symbol;Acc:MGI:1352757] Location: 7:80361331-80475722 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell phagocyte epithelial cell macrophage monocyte granulocyte neutrophil Other: Innate Immune System Nephrin family interactions MAPK family signaling cascades Kirrel3 Gene Information Basic Information Ensembl ID: ENSMUSG00000032036 Description: kirre like nephrin family adhesion molecule 3 [Source:MGI Symbol;Acc:MGI:1914953] Location: 9:34397190-34948012 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron ectodermal cell Other: Nephrin family interactions
Nervous system development Pathway Hierarchies & Genes Sema4D induced cell migration and growth-cone collapse (1 genes) Developmental Biology Nervous system development Axon guidance Semaphorin interactions Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse 1 genes Sema4D mediated inhibition of cell attachment and migration (2 genes) Developmental Biology Nervous system development Axon guidance Semaphorin interactions Sema4D in semaphorin signaling Sema4D mediated inhibition of cell attachment and migration 2 genes CRMPs in Sema3A signaling (1 genes) Developmental Biology Nervous system development Axon guidance Semaphorin interactions CRMPs in Sema3A signaling 1 genes EPH-ephrin mediated repulsion of cells (2 genes) Developmental Biology Nervous system development Axon guidance EPH-Ephrin signaling EPH-ephrin mediated repulsion of cells 2 genes EPHA-mediated growth cone collapse (1 genes) Developmental Biology Nervous system development Axon guidance EPH-Ephrin signaling EPHA-mediated growth cone collapse 1 genes EPHB-mediated forward signaling (5 genes) Developmental Biology Nervous system development Axon guidance EPH-Ephrin signaling EPHB-mediated forward signaling 5 genes NCAM1 interactions (4 genes) Developmental Biology Nervous system development Axon guidance NCAM signaling for neurite out-growth NCAM1 interactions 4 genes Neurofascin interactions (1 genes) Developmental Biology Nervous system development Axon guidance L1CAM interactions Neurofascin interactions 1 genes Recycling pathway of L1 (1 genes) Developmental Biology Nervous system development Axon guidance L1CAM interactions Recycling pathway of L1 1 genes Role of ABL in ROBO-SLIT signaling (2 genes) Developmental Biology Nervous system development Axon guidance Signaling by ROBO receptors Role of ABL in ROBO-SLIT signaling 2 genes SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion (1 genes) Developmental Biology Nervous system development Axon guidance Semaphorin interactions SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 1 genes Signal transduction by L1 (6 genes) Developmental Biology Nervous system development Axon guidance L1CAM interactions Signal transduction by L1 6 genes NCAM signaling for neurite out-growth (2 genes) Developmental Biology Nervous system development Axon guidance NCAM signaling for neurite out-growth 2 genes RET signaling (9 genes) Developmental Biology Nervous system development Axon guidance RET signaling 9 genes Signaling by ROBO receptors (3 genes) Developmental Biology Nervous system development Axon guidance Signaling by ROBO receptors 3 genes	Abl1 Gene Information Basic Information Ensembl ID: ENSMUSG00000026842 Description: c-abl oncogene 1%2C non-receptor tyrosine kinase [Source:MGI Symbol;Acc:MGI:87859] Location: 2:31578388-31694239 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Epigenetic regulation of gene expression Myogenesis Abl2 Gene Information Basic Information Ensembl ID: ENSMUSG00000026596 Description: ABL proto-oncogene 2%2C non-receptor tyrosine kinase [Source:MGI Symbol;Acc:MGI:87860] Location: 1:156386356-156477138 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: bone cell Other: Cytokine Signaling in Immune system Nervous system development Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Arhgef11 Gene Information Basic Information Ensembl ID: ENSMUSG00000041977 Description: Rho guanine nucleotide exchange factor 11 [Source:MGI Symbol;Acc:MGI:2441869] Location: 3:87524866-87645341 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by GPCR Death Receptor Signaling Nervous system development Cdc42 Gene Information Basic Information Ensembl ID: ENSMUSG00000006699 Description: cell division cycle 42 [Source:MGI Symbol;Acc:MGI:106211] Location: 4:137047007-137085031 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: hematopoietic stem cell phagocyte antigen presenting cell macrophage dendritic cell Other: Adaptive Immune System Innate Immune System Signaling by GPCR Col5a2 Gene Information Basic Information Ensembl ID: ENSMUSG00000026042 Description: collagen%2C type V%2C alpha 2 [Source:MGI Symbol;Acc:MGI:88458] Location: 1:45413481-45542442 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast pericyte stellate cell stromal cell mesenchymal cell Other: Degradation of the extracellular matrix Collagen formation Fibronectin matrix formation Col6a2 Gene Information Basic Information Ensembl ID: ENSMUSG00000020241 Description: collagen%2C type VI%2C alpha 2 [Source:MGI Symbol;Acc:MGI:88460] Location: 10:76431596-76459464 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stellate cell pericyte pneumocyte stromal cell epithelial cell Other: Degradation of the extracellular matrix Collagen formation Integrin cell surface interactions Col6a3 Gene Information Basic Information Ensembl ID: ENSMUSG00000048126 Description: collagen%2C type VI%2C alpha 3 [Source:MGI Symbol;Acc:MGI:88461] Location: 1:90693645-90771693 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast pericyte stellate cell stromal cell Other: Degradation of the extracellular matrix Collagen formation Integrin cell surface interactions Creb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000025958 Description: cAMP responsive element binding protein 1 [Source:MGI Symbol;Acc:MGI:88494] Location: 1:64571804-64643707 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Transmission across Chemical Synapses Cytokine Signaling in Immune system Innate Immune System Cxcl12 Gene Information Basic Information Ensembl ID: ENSMUSG00000061353 Description: C-X-C motif chemokine ligand 12 [Source:MGI Symbol;Acc:MGI:103556] Location: 6:117145496-117158328 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stellate cell epithelial cell fibroblast stromal cell smooth muscle cell Other: Signaling by GPCR Nervous system development Dnm3 Gene Information Basic Information Ensembl ID: ENSMUSG00000040265 Description: dynamin 3 [Source:MGI Symbol;Acc:MGI:1341299] Location: 1:161810022-162305603 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Adaptive Immune System Innate Immune System Membrane Trafficking Efna5 Gene Information Basic Information Ensembl ID: ENSMUSG00000048915 Description: ephrin A5 [Source:MGI Symbol;Acc:MGI:107444] Location: 17:62911179-63188312 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell stem cell ectodermal cell motor neuron adipocyte Other: Nervous system development Enah Gene Information Basic Information Ensembl ID: ENSMUSG00000022995 Description: ENAH actin regulator [Source:MGI Symbol;Acc:MGI:108360] Location: 1:181723949-181847555 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell pericyte smooth muscle cell fibroblast motor neuron granulosa cell Other: Nervous system development Fgfr1 Gene Information Basic Information Ensembl ID: ENSMUSG00000031565 Description: fibroblast growth factor receptor 1 [Source:MGI Symbol;Acc:MGI:95522] Location: 8:26003670-26065734 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast chondrocyte muscle cell osteoblast Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Frs2 Gene Information Basic Information Ensembl ID: ENSMUSG00000020170 Description: fibroblast growth factor receptor substrate 2 [Source:MGI Symbol;Acc:MGI:1100860] Location: 10:116905332-116984439 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Fyn Gene Information Basic Information Ensembl ID: ENSMUSG00000019843 Description: Fyn proto-oncogene [Source:MGI Symbol;Acc:MGI:95602] Location: 10:39244851-39441377 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cell surface interactions at the vascular wall Nephrin family interactions Cytokine Signaling in Immune system Gab1 Gene Information Basic Information Ensembl ID: ENSMUSG00000031714 Description: growth factor receptor bound protein 2-associated protein 1 [Source:MGI Symbol;Acc:MGI:108088] Location: 8:81491063-81607148 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte Other: Signaling by Erythropoietin Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Gdnf Gene Information Basic Information Ensembl ID: ENSMUSG00000022144 Description: glial cell line derived neurotrophic factor [Source:MGI Symbol;Acc:MGI:107430] Location: 15:7840327-7867056 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: MAPK family signaling cascades Nervous system development Gpc1 Gene Information Basic Information Ensembl ID: ENSMUSG00000034220 Description: glypican 1 [Source:MGI Symbol;Acc:MGI:1194891] Location: 1:92759367-92788501 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: glial cell podocyte Other: Metabolism of vitamins and cofactors Cell surface interactions at the vascular wall Visual phototransduction Gsk3b Gene Information Basic Information Ensembl ID: ENSMUSG00000022812 Description: glycogen synthase kinase 3 beta [Source:MGI Symbol;Acc:MGI:1861437] Location: 16:37909363-38066446 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by WNT Epigenetic regulation of gene expression Cellular responses to stress Irs2 Gene Information Basic Information Ensembl ID: ENSMUSG00000038894 Description: insulin receptor substrate 2 [Source:MGI Symbol;Acc:MGI:109334] Location: 8:11034681-11058458 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: mural cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades Signaling by Erythropoietin Itga2b Gene Information Basic Information Ensembl ID: ENSMUSG00000034664 Description: integrin alpha 2b [Source:MGI Symbol;Acc:MGI:96601] Location: 11:102344123-102360948 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stromal cell mast cell megakaryocyte erythrocyte progenitor cell basophil stellate cell Other: Integrin cell surface interactions ECM proteoglycans Integrin signaling Itga5 Gene Information Basic Information Ensembl ID: ENSMUSG00000000555 Description: integrin alpha 5 (fibronectin receptor alpha) [Source:MGI Symbol;Acc:MGI:96604] Location: 15:103252713-103275190 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Elastic fibre formation Fibronectin matrix formation Cell surface interactions at the vascular wall Itga9 Gene Information Basic Information Ensembl ID: ENSMUSG00000039115 Description: integrin alpha 9 [Source:MGI Symbol;Acc:MGI:104756] Location: 9:118435758-118730071 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stromal cell pneumocyte Other: Integrin cell surface interactions ECM proteoglycans Nervous system development Itgav Gene Information Basic Information Ensembl ID: ENSMUSG00000027087 Description: integrin alpha V [Source:MGI Symbol;Acc:MGI:96608] Location: 2:83554741-83637260 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell bone cell Other: ECM proteoglycans Non-integrin membrane-ECM interactions Adaptive Immune System Itgb3 Gene Information Basic Information Ensembl ID: ENSMUSG00000020689 Description: integrin beta 3 [Source:MGI Symbol;Acc:MGI:96612] Location: 11:104498826-104561302 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell stromal cell bone cell megakaryocyte Other: Elastic fibre formation Cell surface interactions at the vascular wall Integrin cell surface interactions Lyn Gene Information Basic Information Ensembl ID: ENSMUSG00000042228 Description: LYN proto-oncogene%2C Src family tyrosine kinase [Source:MGI Symbol;Acc:MGI:96892] Location: 4:3678115-3813122 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Platelet Adhesion to exposed collagen Cytokine Signaling in Immune system Adaptive Immune System Met Gene Information Basic Information Ensembl ID: ENSMUSG00000009376 Description: met proto-oncogene [Source:MGI Symbol;Acc:MGI:96969] Location: 6:17463799-17573979 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell intercalated cell Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Mmp2 Gene Information Basic Information Ensembl ID: ENSMUSG00000031740 Description: matrix metallopeptidase 2 [Source:MGI Symbol;Acc:MGI:97009] Location: 8:93553919-93580048 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Degradation of the extracellular matrix Signaling by Nuclear Receptors Nervous system development Nfasc Gene Information Basic Information Ensembl ID: ENSMUSG00000026442 Description: neurofascin [Source:MGI Symbol;Acc:MGI:104753] Location: 1:132492428-132669535 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron bipolar cell astrocyte Other: Innate Immune System Nervous system development Pak1 Gene Information Basic Information Ensembl ID: ENSMUSG00000030774 Description: p21 (RAC1) activated kinase 1 [Source:MGI Symbol;Acc:MGI:1339975] Location: 7:97437748-97561588 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell epithelial cell excitatory neuron Other: Adaptive Immune System Innate Immune System Signaling by GPCR Plcg1 Gene Information Basic Information Ensembl ID: ENSMUSG00000016933 Description: phospholipase C%2C gamma 1 [Source:MGI Symbol;Acc:MGI:97615] Location: 2:160573220-160617680 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Inositol phosphate metabolism Psen1 Gene Information Basic Information Ensembl ID: ENSMUSG00000019969 Description: presenilin 1 [Source:MGI Symbol;Acc:MGI:1202717] Location: 12:83734926-83781973 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Signaling by NOTCH Death Receptor Signaling Ptpn11 Gene Information Basic Information Ensembl ID: ENSMUSG00000043733 Description: protein tyrosine phosphatase%2C non-receptor type 11 [Source:MGI Symbol;Acc:MGI:99511] Location: 5:121268596-121329460 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Nervous system development Cytokine Signaling in Immune system Adaptive Immune System Rap1gap Gene Information Basic Information Ensembl ID: ENSMUSG00000041351 Description: Rap1 GTPase-activating protein [Source:MGI Symbol;Acc:MGI:109338] Location: 4:137392037-137457172 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pancreatic cell oligodendrocyte precursor cell Other: Adaptive Immune System Nervous system development Sdc2 Gene Information Basic Information Ensembl ID: ENSMUSG00000022261 Description: syndecan 2 [Source:MGI Symbol;Acc:MGI:1349165] Location: 15:32920869-33035081 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte osteoblast mural cell Other: Metabolism of vitamins and cofactors Cell surface interactions at the vascular wall Visual phototransduction Sema4d Gene Information Basic Information Ensembl ID: ENSMUSG00000021451 Description: sema domain%2C immunoglobulin domain (Ig)%2C transmembrane domain (TM) and short cytoplasmic domain%2C (semaphorin) 4D [Source:MGI Symbol;Acc:MGI:109244] Location: 13:51839565-51947783 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell Other: Nervous system development Shank3 Gene Information Basic Information Ensembl ID: ENSMUSG00000022623 Description: SH3 and multiple ankyrin repeat domains 3 [Source:MGI Symbol;Acc:MGI:1930016] Location: 15:89383826-89444464 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Protein-protein interactions at synapses Nervous system development Shc1 Gene Information Basic Information Ensembl ID: ENSMUSG00000042626 Description: src homology 2 domain-containing transforming protein C1 [Source:MGI Symbol;Acc:MGI:98296] Location: 3:89325750-89337334 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Innate Immune System Cell surface interactions at the vascular wall Sos1 Gene Information Basic Information Ensembl ID: ENSMUSG00000024241 Description: SOS Ras/Rac guanine nucleotide exchange factor 1 [Source:MGI Symbol;Acc:MGI:98354] Location: 17:80701180-80787882 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System St8sia4 Gene Information Basic Information Ensembl ID: ENSMUSG00000040710 Description: ST8 alpha-N-acetyl-neuraminide alpha-2%2C8-sialyltransferase 4 [Source:MGI Symbol;Acc:MGI:106018] Location: 1:95515407-95595296 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell endothelial cell dendritic cell myeloid progenitor cell Other: Post-translational protein modification Nervous system development Tln1 Gene Information Basic Information Ensembl ID: ENSMUSG00000028465 Description: talin 1 [Source:MGI Symbol;Acc:MGI:1099832] Location: 4:43531519-43562691 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell phagocyte monocyte eosinophil megakaryocyte dendritic cell Other: Integrin signaling Smooth Muscle Contraction MAPK family signaling cascades
Non-integrin membrane-ECM interactions Pathway Hierarchies & Genes Syndecan interactions (12 genes) Extracellular matrix organization Non-integrin membrane-ECM interactions 4 genes Syndecan interactions 8 genes	Acta2 Gene Information Basic Information Ensembl ID: ENSMUSG00000035783 Description: actin alpha 2%2C smooth muscle%2C aorta [Source:MGI Symbol;Acc:MGI:87909] Location: 19:34218490-34232990 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte stellate cell endothelial cell stem cell smooth muscle cell fibroblast mural cell mesangial cell progenitor cell muscle cell mesenchymal cell Other: Non-integrin membrane-ECM interactions Smooth Muscle Contraction Cell junction organization Col1a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000001506 Description: collagen%2C type I%2C alpha 1 [Source:MGI Symbol;Acc:MGI:88467] Location: 11:94827050-94843868 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stellate cell pericyte stromal cell stem cell valve interstitial cell mesenchymal cell endothelial cell Other: ECM proteoglycans Platelet Adhesion to exposed collagen Adaptive Immune System Col1a2 Gene Information Basic Information Ensembl ID: ENSMUSG00000029661 Description: collagen%2C type I%2C alpha 2 [Source:MGI Symbol;Acc:MGI:88468] Location: 6:4504814-4541544 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stellate cell pericyte stem cell stromal cell epithelial cell vascular cell meningeal cell Other: Adaptive Immune System Degradation of the extracellular matrix Collagen formation Col5a2 Gene Information Basic Information Ensembl ID: ENSMUSG00000026042 Description: collagen%2C type V%2C alpha 2 [Source:MGI Symbol;Acc:MGI:88458] Location: 1:45413481-45542442 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast pericyte stellate cell stromal cell mesenchymal cell Other: Degradation of the extracellular matrix Collagen formation Fibronectin matrix formation Ddr1 Gene Information Basic Information Ensembl ID: ENSMUSG00000003534 Description: discoidin domain receptor family%2C member 1 [Source:MGI Symbol;Acc:MGI:99216] Location: 17:35992459-36015513 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Non-integrin membrane-ECM interactions Itga2 Gene Information Basic Information Ensembl ID: ENSMUSG00000015533 Description: integrin alpha 2 [Source:MGI Symbol;Acc:MGI:96600] Location: 13:114969617-115068636 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Specialized T cell Other: Integrin cell surface interactions Non-integrin membrane-ECM interactions ECM proteoglycans Itga6 Gene Information Basic Information Ensembl ID: ENSMUSG00000027111 Description: integrin alpha 6 [Source:MGI Symbol;Acc:MGI:96605] Location: 2:71575960-71688760 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell epithelial cell progenitor cell Other: Cell surface interactions at the vascular wall Integrin cell surface interactions Laminin interactions Itgav Gene Information Basic Information Ensembl ID: ENSMUSG00000027087 Description: integrin alpha V [Source:MGI Symbol;Acc:MGI:96608] Location: 2:83554741-83637260 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell bone cell Other: ECM proteoglycans Non-integrin membrane-ECM interactions Adaptive Immune System Itgb3 Gene Information Basic Information Ensembl ID: ENSMUSG00000020689 Description: integrin beta 3 [Source:MGI Symbol;Acc:MGI:96612] Location: 11:104498826-104561302 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell stromal cell bone cell megakaryocyte Other: Elastic fibre formation Cell surface interactions at the vascular wall Integrin cell surface interactions Itgb4 Gene Information Basic Information Ensembl ID: ENSMUSG00000020758 Description: integrin beta 4 [Source:MGI Symbol;Acc:MGI:96613] Location: 11:115865535-115899238 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell basal cell cardiomyocyte perineurial cell Other: Laminin interactions Non-integrin membrane-ECM interactions Cell junction organization Sdc2 Gene Information Basic Information Ensembl ID: ENSMUSG00000022261 Description: syndecan 2 [Source:MGI Symbol;Acc:MGI:1349165] Location: 15:32920869-33035081 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte osteoblast mural cell Other: Metabolism of vitamins and cofactors Cell surface interactions at the vascular wall Visual phototransduction Tgfb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000002603 Description: transforming growth factor%2C beta 1 [Source:MGI Symbol;Acc:MGI:98725] Location: 7:25386427-25404502 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell hematopoietic stem cell phagocyte monocyte leukocyte megakaryocyte Other: Cell surface interactions at the vascular wall Non-integrin membrane-ECM interactions Elastic fibre formation
Nonsense-Mediated Decay (NMD) Pathway Hierarchies & Genes Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (1 genes) Metabolism of RNA Nonsense-Mediated Decay (NMD) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 1 genes	Ppp2ca Gene Information Basic Information Ensembl ID: ENSMUSG00000020349 Description: protein phosphatase 2 (formerly 2A)%2C catalytic subunit%2C alpha isoform [Source:MGI Symbol;Acc:MGI:1321159] Location: 11:51989508-52018605 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System
O2/CO2 exchange in erythrocytes Pathway Hierarchies & Genes Erythrocytes take up oxygen and release carbon dioxide (2 genes) Transport of small molecules O2/CO2 exchange in erythrocytes Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide 2 genes	Aqp1 Gene Information Basic Information Ensembl ID: ENSMUSG00000004655 Description: aquaporin 1 [Source:MGI Symbol;Acc:MGI:103201] Location: 6:55313417-55325540 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell hematopoietic progenitor cell erythroblast podocyte Other: O2/CO2 exchange in erythrocytes Aquaporin-mediated transport Car2 Gene Information Basic Information Ensembl ID: ENSMUSG00000027562 Description: carbonic anhydrase 2 [Source:MGI Symbol;Acc:MGI:88269] Location: 3:14951333-14965830 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell kidney cell stem cell hematopoietic stem cell erythrocyte glial cell intercalated cell smooth muscle cell hematopoietic progenitor cell erythroid lineage cell ductal cell Other: Reversible hydration of carbon dioxide O2/CO2 exchange in erythrocytes
Olfactory Signaling Pathway Pathway Hierarchies & Genes Olfactory Signaling Pathway (3 genes) Sensory Perception Olfactory Signaling Pathway 3 genes	Gnal Gene Information Basic Information Ensembl ID: ENSMUSG00000024524 Description: guanine nucleotide binding protein%2C alpha stimulating%2C olfactory type [Source:MGI Symbol;Acc:MGI:95774] Location: 18:67221287-67359863 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: projection neuron Other: Transmission across Chemical Synapses Signaling by GPCR Olfactory Signaling Pathway Or10j5 Gene Information Basic Information Ensembl ID: ENSMUSG00000037924 Description: olfactory receptor family 10 subfamily J member 5 [Source:MGI Symbol;Acc:MGI:106648] Location: 1:172777976-172785924 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Olfactory Signaling Pathway Or2c1 Gene Information Basic Information Ensembl ID: ENSMUSG00000059043 Description: olfactory receptor family 2 subfamily C member 1 [Source:MGI Symbol;Acc:MGI:106182] Location: 16:3648742-3662611 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Olfactory Signaling Pathway
Paracetamol ADME Pathway Hierarchies & Genes Paracetamol ADME (5 genes) Drug ADME Paracetamol ADME 5 genes	Abcc1 Gene Information Basic Information Ensembl ID: ENSMUSG00000023088 Description: ATP-binding cassette%2C sub-family C member 1 [Source:MGI Symbol;Acc:MGI:102676] Location: 16:14179422-14293601 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: ABC-family proteins mediated transport Metabolism of porphyrins Metabolism of vitamins and cofactors Abcc3 Gene Information Basic Information Ensembl ID: ENSMUSG00000020865 Description: ATP-binding cassette%2C sub-family C member 3 [Source:MGI Symbol;Acc:MGI:1923658] Location: 11:94234121-94283823 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Paracetamol ADME ABC-family proteins mediated transport Metabolism of lipids Abcc4 Gene Information Basic Information Ensembl ID: ENSMUSG00000032849 Description: ATP-binding cassette%2C sub-family C member 4 [Source:MGI Symbol;Acc:MGI:2443111] Location: 14:118720104-118943631 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell epithelial cell Other: ABC-family proteins mediated transport Platelet activation, signaling and aggregation Azathioprine ADME Abcc5 Gene Information Basic Information Ensembl ID: ENSMUSG00000022822 Description: ATP-binding cassette%2C sub-family C member 5 [Source:MGI Symbol;Acc:MGI:1351644] Location: 16:20150053-20245144 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: embryonic cell Other: ABC-family proteins mediated transport Metabolism of carbohydrates and carbohydrate derivatives Azathioprine ADME Ugt2b34 Gene Information Basic Information Ensembl ID: ENSMUSG00000029260 Description: UDP glucuronosyltransferase 2 family%2C polypeptide B34 [Source:MGI Symbol;Acc:MGI:2140962] Location: 5:87037626-87054796 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Biological oxidations Aspirin ADME Paracetamol ADME
Peptide hormone metabolism Pathway Hierarchies & Genes Synthesis, secretion, and deacylation of Ghrelin (1 genes) Metabolism of proteins Peptide hormone metabolism Incretin synthesis, secretion, and inactivation Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and deacylation of Ghrelin 1 genes Metabolism of Angiotensinogen to Angiotensins (1 genes) Metabolism of proteins Peptide hormone metabolism Metabolism of Angiotensinogen to Angiotensins 1 genes	Ace Gene Information Basic Information Ensembl ID: ENSMUSG00000020681 Description: angiotensin I converting enzyme [Source:MGI Symbol;Acc:MGI:87874] Location: 11:105858771-105880790 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell fibroblast monocyte tuft cell erythroblast Other: Peptide hormone metabolism Lep Gene Information Basic Information Ensembl ID: ENSMUSG00000059201 Description: leptin [Source:MGI Symbol;Acc:MGI:104663] Location: 6:29060219-29073876 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Peptide hormone metabolism
Peroxisomal protein import Pathway Hierarchies & Genes Peroxisomal protein import (1 genes) Protein localization Peroxisomal protein import 1 genes	Nos2 Gene Information Basic Information Ensembl ID: ENSMUSG00000020826 Description: nitric oxide synthase 2%2C inducible [Source:MGI Symbol;Acc:MGI:97361] Location: 11:78811613-78851080 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: macrophage Other: Innate Immune System Platelet homeostasis Peroxisomal protein import
Plasma lipoprotein assembly, remodeling, and clearance Pathway Hierarchies & Genes Assembly of active LPL and LIPC lipase complexes (1 genes) Transport of small molecules Plasma lipoprotein assembly, remodeling, and clearance Plasma lipoprotein remodeling Assembly of active LPL and LIPC lipase complexes 1 genes HDL remodeling (1 genes) Transport of small molecules Plasma lipoprotein assembly, remodeling, and clearance Plasma lipoprotein remodeling HDL remodeling 1 genes VLDLR internalisation and degradation (1 genes) Transport of small molecules Plasma lipoprotein assembly, remodeling, and clearance Plasma lipoprotein clearance VLDLR internalisation and degradation 1 genes	Abcg1 Gene Information Basic Information Ensembl ID: ENSMUSG00000024030 Description: ATP binding cassette subfamily G member 1 [Source:MGI Symbol;Acc:MGI:107704] Location: 17:31276649-31336962 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Plasma lipoprotein assembly, remodeling, and clearance ABC-family proteins mediated transport Lpl Gene Information Basic Information Ensembl ID: ENSMUSG00000015568 Description: lipoprotein lipase [Source:MGI Symbol;Acc:MGI:96820] Location: 8:69333143-69360100 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: preadipocyte phagocyte fibroblast epithelial cell stromal cell erythrocyte dendritic cell macrophage endothelial cell antigen presenting cell adipocyte Other: Plasma lipoprotein assembly, remodeling, and clearance Metabolism of vitamins and cofactors Visual phototransduction Mylip Gene Information Basic Information Ensembl ID: ENSMUSG00000038175 Description: myosin regulatory light chain interacting protein [Source:MGI Symbol;Acc:MGI:2388271] Location: 13:45543218-45565498 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell microglia Other: Adaptive Immune System Plasma lipoprotein assembly, remodeling, and clearance
Platelet Adhesion to exposed collagen Pathway Hierarchies & Genes Platelet Adhesion to exposed collagen (4 genes) Hemostasis Platelet Adhesion to exposed collagen 4 genes	Col1a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000001506 Description: collagen%2C type I%2C alpha 1 [Source:MGI Symbol;Acc:MGI:88467] Location: 11:94827050-94843868 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stellate cell pericyte stromal cell stem cell valve interstitial cell mesenchymal cell endothelial cell Other: ECM proteoglycans Platelet Adhesion to exposed collagen Adaptive Immune System Col1a2 Gene Information Basic Information Ensembl ID: ENSMUSG00000029661 Description: collagen%2C type I%2C alpha 2 [Source:MGI Symbol;Acc:MGI:88468] Location: 6:4504814-4541544 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stellate cell pericyte stem cell stromal cell epithelial cell vascular cell meningeal cell Other: Adaptive Immune System Degradation of the extracellular matrix Collagen formation Fyn Gene Information Basic Information Ensembl ID: ENSMUSG00000019843 Description: Fyn proto-oncogene [Source:MGI Symbol;Acc:MGI:95602] Location: 10:39244851-39441377 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cell surface interactions at the vascular wall Nephrin family interactions Cytokine Signaling in Immune system Lyn Gene Information Basic Information Ensembl ID: ENSMUSG00000042228 Description: LYN proto-oncogene%2C Src family tyrosine kinase [Source:MGI Symbol;Acc:MGI:96892] Location: 4:3678115-3813122 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Platelet Adhesion to exposed collagen Cytokine Signaling in Immune system Adaptive Immune System
Platelet activation, signaling and aggregation Pathway Hierarchies & Genes Platelet Aggregation (Plug Formation) (10 genes) Hemostasis Platelet activation, signaling and aggregation GPVI-mediated activation cascade 7 genes GP1b-IX-V activation signalling 1 genes Platelet Aggregation (Plug Formation) 2 genes Platelet Aggregation (Plug Formation) (14 genes) Hemostasis Platelet activation, signaling and aggregation Response to elevated platelet cytosolic Ca2+ Platelet degranulation 10 genes Platelet Aggregation (Plug Formation) 4 genes Thrombin signalling through proteinase activated receptors (PARs) (3 genes) Hemostasis Platelet activation, signaling and aggregation Signal amplification ADP signalling through P2Y purinoceptor 12 2 genes Thrombin signalling through proteinase activated receptors (PARs) 1 genes Thrombin signalling through proteinase activated receptors (PARs) (1 genes) Hemostasis Platelet activation, signaling and aggregation Signal amplification Thromboxane signalling through TP receptor Thrombin signalling through proteinase activated receptors (PARs) 1 genes Thrombin signalling through proteinase activated receptors (PARs) (5 genes) Hemostasis Platelet activation, signaling and aggregation Signal amplification ADP signalling through P2Y purinoceptor 1 2 genes Thrombin signalling through proteinase activated receptors (PARs) 3 genes Adrenaline signalling through Alpha-2 adrenergic receptor (2 genes) Hemostasis Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation) Adrenaline signalling through Alpha-2 adrenergic receptor 2 genes Platelet Aggregation (Plug Formation) (3 genes) Hemostasis Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation) 3 genes Thrombin signalling through proteinase activated receptors (PARs) (3 genes) Hemostasis Platelet activation, signaling and aggregation Thrombin signalling through proteinase activated receptors (PARs) 3 genes	Abcc4 Gene Information Basic Information Ensembl ID: ENSMUSG00000032849 Description: ATP-binding cassette%2C sub-family C member 4 [Source:MGI Symbol;Acc:MGI:2443111] Location: 14:118720104-118943631 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell epithelial cell Other: ABC-family proteins mediated transport Platelet activation, signaling and aggregation Azathioprine ADME Adra2a Gene Information Basic Information Ensembl ID: ENSMUSG00000033717 Description: adrenergic receptor%2C alpha 2a [Source:MGI Symbol;Acc:MGI:87934] Location: 19:54032582-54037413 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte retina cell mural cell Other: Integration of energy metabolism Signaling by GPCR Surfactant metabolism Adra2c Gene Information Basic Information Ensembl ID: ENSMUSG00000045318 Description: adrenergic receptor%2C alpha 2c [Source:MGI Symbol;Acc:MGI:87936] Location: 5:35435663-35439107 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Integration of energy metabolism Signaling by GPCR Surfactant metabolism Arrb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000018909 Description: arrestin%2C beta 1 [Source:MGI Symbol;Acc:MGI:99473] Location: 7:99184673-99255978 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stromal cell Other: Membrane Trafficking Signaling by GPCR Signaling by Hedgehog Arrb2 Gene Information Basic Information Ensembl ID: ENSMUSG00000060216 Description: arrestin%2C beta 2 [Source:MGI Symbol;Acc:MGI:99474] Location: 11:70323461-70331654 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell antigen presenting cell Other: Signaling by WNT Membrane Trafficking Signaling by GPCR Bcar1 Gene Information Basic Information Ensembl ID: ENSMUSG00000031955 Description: breast cancer anti-estrogen resistance 1 [Source:MGI Symbol;Acc:MGI:108091] Location: 8:112437106-112470441 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Integrin signaling Platelet activation, signaling and aggregation Signaling by Non-Receptor Tyrosine Kinases Cdc42 Gene Information Basic Information Ensembl ID: ENSMUSG00000006699 Description: cell division cycle 42 [Source:MGI Symbol;Acc:MGI:106211] Location: 4:137047007-137085031 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: hematopoietic stem cell phagocyte antigen presenting cell macrophage dendritic cell Other: Adaptive Immune System Innate Immune System Signaling by GPCR Col1a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000001506 Description: collagen%2C type I%2C alpha 1 [Source:MGI Symbol;Acc:MGI:88467] Location: 11:94827050-94843868 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stellate cell pericyte stromal cell stem cell valve interstitial cell mesenchymal cell endothelial cell Other: ECM proteoglycans Platelet Adhesion to exposed collagen Adaptive Immune System Col1a2 Gene Information Basic Information Ensembl ID: ENSMUSG00000029661 Description: collagen%2C type I%2C alpha 2 [Source:MGI Symbol;Acc:MGI:88468] Location: 6:4504814-4541544 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stellate cell pericyte stem cell stromal cell epithelial cell vascular cell meningeal cell Other: Adaptive Immune System Degradation of the extracellular matrix Collagen formation F13a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000039109 Description: coagulation factor XIII%2C A1 subunit [Source:MGI Symbol;Acc:MGI:1921395] Location: 13:37051152-37234220 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: hematopoietic stem cell phagocyte monocyte erythroid lineage cell T cell macrophage Other: Formation of Fibrin Clot (Clotting Cascade) Platelet activation, signaling and aggregation F2r Gene Information Basic Information Ensembl ID: ENSMUSG00000048376 Description: coagulation factor II thrombin receptor [Source:MGI Symbol;Acc:MGI:101802] Location: 13:95738311-95754995 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell fibroblast cardiomyocyte endocardial cell megakaryocyte Other: Formation of Fibrin Clot (Clotting Cascade) Signaling by GPCR Platelet activation, signaling and aggregation Flna Gene Information Basic Information Ensembl ID: ENSMUSG00000031328 Description: filamin%2C alpha [Source:MGI Symbol;Acc:MGI:95556] Location: X:73267067-73293426 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte endothelial cell stem cell smooth muscle cell fibroblast monocyte epithelial cell neutrophil mural cell Other: Cell junction organization Platelet activation, signaling and aggregation Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Fyn Gene Information Basic Information Ensembl ID: ENSMUSG00000019843 Description: Fyn proto-oncogene [Source:MGI Symbol;Acc:MGI:95602] Location: 10:39244851-39441377 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cell surface interactions at the vascular wall Nephrin family interactions Cytokine Signaling in Immune system Gna11 Gene Information Basic Information Ensembl ID: ENSMUSG00000034781 Description: guanine nucleotide binding protein%2C alpha 11 [Source:MGI Symbol;Acc:MGI:95766] Location: 10:81364558-81381024 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell endothelial cell enterocyte Other: Integration of energy metabolism Signaling by GPCR Protein folding Gna13 Gene Information Basic Information Ensembl ID: ENSMUSG00000020611 Description: guanine nucleotide binding protein%2C alpha 13 [Source:MGI Symbol;Acc:MGI:95768] Location: 11:109253657-109292195 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell developing T cell innate lymphoid cell Other: Signaling by GPCR Death Receptor Signaling Platelet activation, signaling and aggregation Gna14 Gene Information Basic Information Ensembl ID: ENSMUSG00000024697 Description: guanine nucleotide binding protein%2C alpha 14 [Source:MGI Symbol;Acc:MGI:95769] Location: 19:16413126-16588184 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell epithelial cell Other: Integration of energy metabolism Signaling by GPCR Protein folding Gnai1 Gene Information Basic Information Ensembl ID: ENSMUSG00000057614 Description: G protein subunit alpha i1 [Source:MGI Symbol;Acc:MGI:95771] Location: 5:18470133-18565353 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: mast cell adipocyte Other: Transmission across Chemical Synapses Integration of energy metabolism Signaling by GPCR Gnai3 Gene Information Basic Information Ensembl ID: ENSMUSG00000000001 Description: G protein subunit alpha i3 [Source:MGI Symbol;Acc:MGI:95773] Location: 3:108014596-108053462 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Transmission across Chemical Synapses Signaling by GPCR Platelet activation, signaling and aggregation Gnaq Gene Information Basic Information Ensembl ID: ENSMUSG00000024639 Description: guanine nucleotide binding protein%2C alpha q polypeptide [Source:MGI Symbol;Acc:MGI:95776] Location: 19:16110195-16364827 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: antigen presenting cell Other: Integration of energy metabolism Signaling by GPCR Protein folding Gngt2 Gene Information Basic Information Ensembl ID: ENSMUSG00000038811 Description: guanine nucleotide binding protein (G protein)%2C gamma transducing activity polypeptide 2 [Source:MGI Symbol;Acc:MGI:893584] Location: 11:95728042-95736560 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell dendritic cell phagocyte monocyte myeloid cell plasma cell macrophage photoreceptor cell Other: Platelet homeostasis Transmission across Chemical Synapses Potassium Channels Itga2b Gene Information Basic Information Ensembl ID: ENSMUSG00000034664 Description: integrin alpha 2b [Source:MGI Symbol;Acc:MGI:96601] Location: 11:102344123-102360948 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stromal cell mast cell megakaryocyte erythrocyte progenitor cell basophil stellate cell Other: Integrin cell surface interactions ECM proteoglycans Integrin signaling Itgb3 Gene Information Basic Information Ensembl ID: ENSMUSG00000020689 Description: integrin beta 3 [Source:MGI Symbol;Acc:MGI:96612] Location: 11:104498826-104561302 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell stromal cell bone cell megakaryocyte Other: Elastic fibre formation Cell surface interactions at the vascular wall Integrin cell surface interactions Lyn Gene Information Basic Information Ensembl ID: ENSMUSG00000042228 Description: LYN proto-oncogene%2C Src family tyrosine kinase [Source:MGI Symbol;Acc:MGI:96892] Location: 4:3678115-3813122 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Platelet Adhesion to exposed collagen Cytokine Signaling in Immune system Adaptive Immune System P2ry1 Gene Information Basic Information Ensembl ID: ENSMUSG00000027765 Description: purinergic receptor P2Y%2C G-protein coupled 1 [Source:MGI Symbol;Acc:MGI:105049] Location: 3:60910216-60916403 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by GPCR Platelet activation, signaling and aggregation Pdpn Gene Information Basic Information Ensembl ID: ENSMUSG00000028583 Description: podoplanin [Source:MGI Symbol;Acc:MGI:103098] Location: 4:142994001-143026134 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: mesothelial cell pneumocyte lymphocyte pericyte Other: Platelet activation, signaling and aggregation Pecam1 Gene Information Basic Information Ensembl ID: ENSMUSG00000020717 Description: platelet/endothelial cell adhesion molecule 1 [Source:MGI Symbol;Acc:MGI:97537] Location: 11:106545043-106641454 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell epithelial cell Other: Innate Immune System Cell surface interactions at the vascular wall Integrin cell surface interactions Pla2g4a Gene Information Basic Information Ensembl ID: ENSMUSG00000056220 Description: phospholipase A2%2C group IVA (cytosolic%2C calcium-dependent) [Source:MGI Symbol;Acc:MGI:1195256] Location: 1:149705369-149837041 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Membrane Trafficking Signaling by GPCR Platelet homeostasis Ptpn11 Gene Information Basic Information Ensembl ID: ENSMUSG00000043733 Description: protein tyrosine phosphatase%2C non-receptor type 11 [Source:MGI Symbol;Acc:MGI:99511] Location: 5:121268596-121329460 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Nervous system development Cytokine Signaling in Immune system Adaptive Immune System Ptpn6 Gene Information Basic Information Ensembl ID: ENSMUSG00000004266 Description: protein tyrosine phosphatase%2C non-receptor type 6 [Source:MGI Symbol;Acc:MGI:96055] Location: 6:124697670-124715677 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell Naive B cell tuft cell monocyte dendritic cell macrophage Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Rac2 Gene Information Basic Information Ensembl ID: ENSMUSG00000033220 Description: Rac family small GTPase 2 [Source:MGI Symbol;Acc:MGI:97846] Location: 15:78443367-78456983 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell dendritic cell developing T cell tuft cell CD4+ T cell mast cell T cell granulocyte leukocyte lymphocyte Other: Innate Immune System Signaling by WNT Platelet activation, signaling and aggregation Selp Gene Information Basic Information Ensembl ID: ENSMUSG00000026580 Description: selectin%2C platelet [Source:MGI Symbol;Acc:MGI:98280] Location: 1:163942833-163977595 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Cell surface interactions at the vascular wall Platelet activation, signaling and aggregation Shc1 Gene Information Basic Information Ensembl ID: ENSMUSG00000042626 Description: src homology 2 domain-containing transforming protein C1 [Source:MGI Symbol;Acc:MGI:98296] Location: 3:89325750-89337334 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Innate Immune System Cell surface interactions at the vascular wall Sos1 Gene Information Basic Information Ensembl ID: ENSMUSG00000024241 Description: SOS Ras/Rac guanine nucleotide exchange factor 1 [Source:MGI Symbol;Acc:MGI:98354] Location: 17:80701180-80787882 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Syk Gene Information Basic Information Ensembl ID: ENSMUSG00000021457 Description: spleen tyrosine kinase [Source:MGI Symbol;Acc:MGI:99515] Location: 13:52737209-52802828 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell Naive B cell monocyte granulocyte Other: Integrin signaling Cytokine Signaling in Immune system Adaptive Immune System Tgfb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000002603 Description: transforming growth factor%2C beta 1 [Source:MGI Symbol;Acc:MGI:98725] Location: 7:25386427-25404502 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell hematopoietic stem cell phagocyte monocyte leukocyte megakaryocyte Other: Cell surface interactions at the vascular wall Non-integrin membrane-ECM interactions Elastic fibre formation Tgfb2 Gene Information Basic Information Ensembl ID: ENSMUSG00000039239 Description: transforming growth factor%2C beta 2 [Source:MGI Symbol;Acc:MGI:98726] Location: 1:186354989-186438186 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: glial cell endothelial cell astrocyte Other: Elastic fibre formation Platelet activation, signaling and aggregation Signaling by TGFB family members Tgfb3 Gene Information Basic Information Ensembl ID: ENSMUSG00000021253 Description: transforming growth factor%2C beta 3 [Source:MGI Symbol;Acc:MGI:98727] Location: 12:86103519-86125815 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: mesothelial cell Other: Elastic fibre formation Platelet activation, signaling and aggregation Signaling by TGFB family members Thbs1 Gene Information Basic Information Ensembl ID: ENSMUSG00000040152 Description: thrombospondin 1 [Source:MGI Symbol;Acc:MGI:98737] Location: 2:117942357-117957614 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell fibroblast phagocyte epithelial cell monocyte mural cell megakaryocyte dendritic cell Other: Integrin cell surface interactions Post-translational protein modification Platelet activation, signaling and aggregation Tln1 Gene Information Basic Information Ensembl ID: ENSMUSG00000028465 Description: talin 1 [Source:MGI Symbol;Acc:MGI:1099832] Location: 4:43531519-43562691 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell phagocyte monocyte eosinophil megakaryocyte dendritic cell Other: Integrin signaling Smooth Muscle Contraction MAPK family signaling cascades Vegfa Gene Information Basic Information Ensembl ID: ENSMUSG00000023951 Description: vascular endothelial growth factor A [Source:MGI Symbol;Acc:MGI:103178] Location: 17:46327919-46343295 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell stellate cell mast cell stromal cell Other: Platelet activation, signaling and aggregation Signaling by Receptor Tyrosine Kinases Vegfc Gene Information Basic Information Ensembl ID: ENSMUSG00000031520 Description: vascular endothelial growth factor C [Source:MGI Symbol;Acc:MGI:109124] Location: 8:54530641-54640131 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Platelet activation, signaling and aggregation Signaling by Receptor Tyrosine Kinases
Platelet homeostasis Pathway Hierarchies & Genes Elevation of cytosolic Ca2+ levels (1 genes) Hemostasis Platelet homeostasis Platelet calcium homeostasis Elevation of cytosolic Ca2+ levels 1 genes cGMP effects (1 genes) Hemostasis Platelet homeostasis Nitric oxide stimulates guanylate cyclase cGMP effects 1 genes Nitric oxide stimulates guanylate cyclase (1 genes) Hemostasis Platelet homeostasis Nitric oxide stimulates guanylate cyclase 1 genes Platelet sensitization by LDL (4 genes) Hemostasis Platelet homeostasis Platelet sensitization by LDL 4 genes Prostacyclin signalling through prostacyclin receptor (3 genes) Hemostasis Platelet homeostasis Prostacyclin signalling through prostacyclin receptor 3 genes	Fgr Gene Information Basic Information Ensembl ID: ENSMUSG00000028874 Description: FGR proto-oncogene%2C Src family tyrosine kinase [Source:MGI Symbol;Acc:MGI:95527] Location: 4:132701406-132729221 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Platelet homeostasis Gngt2 Gene Information Basic Information Ensembl ID: ENSMUSG00000038811 Description: guanine nucleotide binding protein (G protein)%2C gamma transducing activity polypeptide 2 [Source:MGI Symbol;Acc:MGI:893584] Location: 11:95728042-95736560 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell dendritic cell phagocyte monocyte myeloid cell plasma cell macrophage photoreceptor cell Other: Platelet homeostasis Transmission across Chemical Synapses Potassium Channels Nos2 Gene Information Basic Information Ensembl ID: ENSMUSG00000020826 Description: nitric oxide synthase 2%2C inducible [Source:MGI Symbol;Acc:MGI:97361] Location: 11:78811613-78851080 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: macrophage Other: Innate Immune System Platelet homeostasis Peroxisomal protein import P2rx7 Gene Information Basic Information Ensembl ID: ENSMUSG00000029468 Description: purinergic receptor P2X%2C ligand-gated ion channel%2C 7 [Source:MGI Symbol;Acc:MGI:1339957] Location: 5:122781974-122829495 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Platelet homeostasis Pde10a Gene Information Basic Information Ensembl ID: ENSMUSG00000023868 Description: phosphodiesterase 10A [Source:MGI Symbol;Acc:MGI:1345143] Location: 17:8744204-9205480 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron stem cell epithelial cell Other: Signaling by GPCR Platelet homeostasis Pecam1 Gene Information Basic Information Ensembl ID: ENSMUSG00000020717 Description: platelet/endothelial cell adhesion molecule 1 [Source:MGI Symbol;Acc:MGI:97537] Location: 11:106545043-106641454 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell epithelial cell Other: Innate Immune System Cell surface interactions at the vascular wall Integrin cell surface interactions Pla2g4a Gene Information Basic Information Ensembl ID: ENSMUSG00000056220 Description: phospholipase A2%2C group IVA (cytosolic%2C calcium-dependent) [Source:MGI Symbol;Acc:MGI:1195256] Location: 1:149705369-149837041 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Membrane Trafficking Signaling by GPCR Platelet homeostasis Ppp2ca Gene Information Basic Information Ensembl ID: ENSMUSG00000020349 Description: protein phosphatase 2 (formerly 2A)%2C catalytic subunit%2C alpha isoform [Source:MGI Symbol;Acc:MGI:1321159] Location: 11:51989508-52018605 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Ptpn11 Gene Information Basic Information Ensembl ID: ENSMUSG00000043733 Description: protein tyrosine phosphatase%2C non-receptor type 11 [Source:MGI Symbol;Acc:MGI:99511] Location: 5:121268596-121329460 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Nervous system development Cytokine Signaling in Immune system Adaptive Immune System Ptpn6 Gene Information Basic Information Ensembl ID: ENSMUSG00000004266 Description: protein tyrosine phosphatase%2C non-receptor type 6 [Source:MGI Symbol;Acc:MGI:96055] Location: 6:124697670-124715677 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell Naive B cell tuft cell monocyte dendritic cell macrophage Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System
Post-translational protein modification Pathway Hierarchies & Genes Ovarian tumor domain proteases (1 genes) Metabolism of proteins Post-translational protein modification SUMOylation SUMO E3 ligases SUMOylate target proteins SUMOylation of intracellular receptors Deubiquitination Ovarian tumor domain proteases 1 genes Sialic acid metabolism (1 genes) Metabolism of proteins Post-translational protein modification Asparagine N-linked glycosylation Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Synthesis of substrates in N-glycan biosythesis Sialic acid metabolism 1 genes SUMOylation of DNA damage response and repair proteins (1 genes) Metabolism of proteins Post-translational protein modification SUMOylation SUMO E3 ligases SUMOylate target proteins SUMOylation of DNA damage response and repair proteins 1 genes SUMOylation of immune response proteins (1 genes) Metabolism of proteins Post-translational protein modification SUMOylation SUMO E3 ligases SUMOylate target proteins SUMOylation of immune response proteins 1 genes Josephin domain DUBs (1 genes) Metabolism of proteins Post-translational protein modification Deubiquitination Josephin domain DUBs 1 genes Metalloprotease DUBs (1 genes) Metabolism of proteins Post-translational protein modification Deubiquitination Metalloprotease DUBs 1 genes O-glycosylation of TSR domain-containing proteins (4 genes) Metabolism of proteins Post-translational protein modification O-linked glycosylation O-glycosylation of TSR domain-containing proteins 4 genes O-linked glycosylation of mucins (1 genes) Metabolism of proteins Post-translational protein modification O-linked glycosylation O-linked glycosylation of mucins 1 genes Ovarian tumor domain proteases (3 genes) Metabolism of proteins Post-translational protein modification Deubiquitination Ovarian tumor domain proteases 3 genes Post-translational protein phosphorylation (4 genes) Metabolism of proteins Post-translational protein modification Post-translational modification: synthesis of GPI-anchored proteins 3 genes Post-translational protein phosphorylation 1 genes Synthesis of active ubiquitin: roles of E1 and E2 enzymes (1 genes) Metabolism of proteins Post-translational protein modification Protein ubiquitination Synthesis of active ubiquitin: roles of E1 and E2 enzymes 1 genes Transport to the Golgi and subsequent modification (2 genes) Metabolism of proteins Post-translational protein modification Asparagine N-linked glycosylation Transport to the Golgi and subsequent modification 2 genes Ub-specific processing proteases (20 genes) Metabolism of proteins Post-translational protein modification Deubiquitination Ub-specific processing proteases 20 genes Neddylation (4 genes) Metabolism of proteins Post-translational protein modification Neddylation 4 genes O-linked glycosylation (1 genes) Metabolism of proteins Post-translational protein modification O-linked glycosylation 1 genes Post-translational protein phosphorylation (10 genes) Metabolism of proteins Post-translational protein modification Post-translational protein phosphorylation 10 genes RAB geranylgeranylation (2 genes) Metabolism of proteins Post-translational protein modification RAB geranylgeranylation 2 genes	Adamts12 Gene Information Basic Information Ensembl ID: ENSMUSG00000047497 Description: ADAM metallopeptidase with thrombospondin type 1 motif 12 [Source:MGI Symbol;Acc:MGI:2146046] Location: 15:11064876-11349317 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte preadipocyte mesenchymal cell Other: Post-translational protein modification Adamts2 Gene Information Basic Information Ensembl ID: ENSMUSG00000036545 Description: ADAM metallopeptidase with thrombospondin type 1 motif 2 [Source:MGI Symbol;Acc:MGI:1347356] Location: 11:50492911-50698400 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast epithelial cell osteoblast Other: Collagen formation Post-translational protein modification Adamts9 Gene Information Basic Information Ensembl ID: ENSMUSG00000030022 Description: ADAM metallopeptidase with thrombospondin type 1 motif 9 [Source:MGI Symbol;Acc:MGI:1916320] Location: 6:92749680-92920473 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell pancreatic cell Other: Post-translational protein modification Adrb2 Gene Information Basic Information Ensembl ID: ENSMUSG00000045730 Description: adrenergic receptor%2C beta 2 [Source:MGI Symbol;Acc:MGI:87938] Location: 18:62310887-62313030 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: smooth muscle cell erythroblast Other: Membrane Trafficking Signaling by GPCR Post-translational protein modification Arrb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000018909 Description: arrestin%2C beta 1 [Source:MGI Symbol;Acc:MGI:99473] Location: 7:99184673-99255978 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stromal cell Other: Membrane Trafficking Signaling by GPCR Signaling by Hedgehog Arrb2 Gene Information Basic Information Ensembl ID: ENSMUSG00000060216 Description: arrestin%2C beta 2 [Source:MGI Symbol;Acc:MGI:99474] Location: 11:70323461-70331654 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell antigen presenting cell Other: Signaling by WNT Membrane Trafficking Signaling by GPCR B3gnt8 Gene Information Basic Information Ensembl ID: ENSMUSG00000059479 Description: UDP-GlcNAc:betaGal beta-1%2C3-N-acetylglucosaminyltransferase 8 [Source:MGI Symbol;Acc:MGI:2385269] Location: 7:25326079-25334525 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Post-translational protein modification Babam2 Gene Information Basic Information Ensembl ID: ENSMUSG00000052139 Description: BRISC and BRCA1 A complex member 2 [Source:MGI Symbol;Acc:MGI:1333875] Location: 5:31855028-32242306 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: DNA Double-Strand Break Repair Post-translational protein modification Cell Cycle Checkpoints Bmp4 Gene Information Basic Information Ensembl ID: ENSMUSG00000021835 Description: bone morphogenetic protein 4 [Source:MGI Symbol;Acc:MGI:88180] Location: 14:46620977-46628126 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stem cell fibroblast epithelial cell smooth muscle cell ectodermal cell endothelial cell mesodermal cell Other: Elastic fibre formation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein modification Ccn1 Gene Information Basic Information Ensembl ID: ENSMUSG00000028195 Description: cellular communication network factor 1 [Source:MGI Symbol;Acc:MGI:88613] Location: 3:145352731-145355736 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stem cell endothelial cell epithelial cell fibroblast astrocyte Other: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein modification Cdh2 Gene Information Basic Information Ensembl ID: ENSMUSG00000024304 Description: cadherin 2 [Source:MGI Symbol;Acc:MGI:88355] Location: 18:16721934-16942303 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte stellate cell glial cell skeletal muscle cell motor neuron osteoblast epithelial cell Other: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cell junction organization Myogenesis Cdk1 Gene Information Basic Information Ensembl ID: ENSMUSG00000019942 Description: cyclin dependent kinase 1 [Source:MGI Symbol;Acc:MGI:88351] Location: 10:69170976-69188768 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: proliferative cell Other: Cytokine Signaling in Immune system Cilium Assembly MAPK family signaling cascades Ckap4 Gene Information Basic Information Ensembl ID: ENSMUSG00000046841 Description: cytoskeleton-associated protein 4 [Source:MGI Symbol;Acc:MGI:2444926] Location: 10:84362169-84369926 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell fibroblast smooth muscle cell granulocyte epithelial cell osteoblast Other: Innate Immune System Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Surfactant metabolism Csf1 Gene Information Basic Information Ensembl ID: ENSMUSG00000014599 Description: colony stimulating factor 1 (macrophage) [Source:MGI Symbol;Acc:MGI:1339753] Location: 3:107648364-107667785 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell endothelial cell basophil eosinophil Other: Cytokine Signaling in Immune system Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein modification Esr1 Gene Information Basic Information Ensembl ID: ENSMUSG00000019768 Description: estrogen receptor 1 (alpha) [Source:MGI Symbol;Acc:MGI:1352467] Location: 10:4561593-4955614 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by Receptor Tyrosine Kinases Cellular responses to stress Post-translational protein modification Fam20c Gene Information Basic Information Ensembl ID: ENSMUSG00000025854 Description: FAM20C%2C golgi associated secretory pathway kinase [Source:MGI Symbol;Acc:MGI:2136853] Location: 5:138740269-138795832 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein modification Fem1a Gene Information Basic Information Ensembl ID: ENSMUSG00000043683 Description: fem 1 homolog a [Source:MGI Symbol;Acc:MGI:1335089] Location: 17:56563810-56570610 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Post-translational protein modification Fem1b Gene Information Basic Information Ensembl ID: ENSMUSG00000032244 Description: fem 1 homolog b [Source:MGI Symbol;Acc:MGI:1335087] Location: 9:62699103-62719216 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: embryonic cell Other: Post-translational protein modification Gata3 Gene Information Basic Information Ensembl ID: ENSMUSG00000015619 Description: GATA binding protein 3 [Source:MGI Symbol;Acc:MGI:95663] Location: 2:9861889-9894845 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Regulatory T cell epithelial cell stem cell CD4+ T cell innate lymphoid cell developing T cell mesangial cell Other: Post-translational protein modification RNA Polymerase II Transcription Signaling by Nuclear Receptors Gpc3 Gene Information Basic Information Ensembl ID: ENSMUSG00000055653 Description: glypican 3 [Source:MGI Symbol;Acc:MGI:104903] Location: X:51361303-51702827 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell stromal cell embryonic cell fibroblast epithelial cell Other: Metabolism of vitamins and cofactors Visual phototransduction Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Gria1 Gene Information Basic Information Ensembl ID: ENSMUSG00000020524 Description: glutamate receptor%2C ionotropic%2C AMPA1 (alpha 1) [Source:MGI Symbol;Acc:MGI:95808] Location: 11:56902213-57221070 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: bergmann glial cell neuron Other: Transmission across Chemical Synapses Membrane Trafficking Post-translational protein modification Il33 Gene Information Basic Information Ensembl ID: ENSMUSG00000024810 Description: interleukin 33 [Source:MGI Symbol;Acc:MGI:1924375] Location: 19:29902514-29938118 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stellate cell pneumocyte stem cell fibroblast epithelial cell glial cell oligodendrocyte Other: Cytokine Signaling in Immune system Post-translational protein modification Intracellular signaling by second messengers Izumo1r Gene Information Basic Information Ensembl ID: ENSMUSG00000031933 Description: IZUMO1 receptor%2C JUNO [Source:MGI Symbol;Acc:MGI:1929185] Location: 9:14797110-14815245 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell Regulatory T cell CD4+ T cell Other: Post-translational protein modification Map3k7 Gene Information Basic Information Ensembl ID: ENSMUSG00000028284 Description: mitogen-activated protein kinase kinase kinase 7 [Source:MGI Symbol;Acc:MGI:1346877] Location: 4:31964097-32023467 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Men1 Gene Information Basic Information Ensembl ID: ENSMUSG00000024947 Description: multiple endocrine neoplasia 1 [Source:MGI Symbol;Acc:MGI:1316736] Location: 19:6385009-6390921 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by WNT Epigenetic regulation of gene expression Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Mmrn2 Gene Information Basic Information Ensembl ID: ENSMUSG00000041445 Description: multimerin 2 [Source:MGI Symbol;Acc:MGI:2385618] Location: 14:34097422-34126244 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell smooth muscle cell Other: Post-translational protein modification Msln Gene Information Basic Information Ensembl ID: ENSMUSG00000063011 Description: mesothelin [Source:MGI Symbol;Acc:MGI:1888992] Location: 17:25967587-25973352 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell fibroblast pneumocyte mesothelial cell Other: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein modification Myc Gene Information Basic Information Ensembl ID: ENSMUSG00000022346 Description: myelocytomatosis oncogene [Source:MGI Symbol;Acc:MGI:97250] Location: 15:61857240-61862223 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Post-translational protein modification RNA Polymerase II Transcription Nsf Gene Information Basic Information Ensembl ID: ENSMUSG00000034187 Description: N-ethylmaleimide sensitive fusion protein [Source:MGI Symbol;Acc:MGI:104560] Location: 11:103712608-103844882 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron epithelial cell Naive B cell Other: Transmission across Chemical Synapses Membrane Trafficking Post-translational protein modification Nup85 Gene Information Basic Information Ensembl ID: ENSMUSG00000020739 Description: nucleoporin 85 [Source:MGI Symbol;Acc:MGI:3046173] Location: 11:115455260-115474811 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: bone cell Other: Metabolism of non-coding RNA Gene Silencing by RNA Cellular responses to stress Prkn Gene Information Basic Information Ensembl ID: ENSMUSG00000023826 Description: parkin RBR E3 ubiquitin protein ligase [Source:MGI Symbol;Acc:MGI:1355296] Location: 17:11059271-12282248 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Adaptive Immune System Macroautophagy Regulated Necrosis Rab40c Gene Information Basic Information Ensembl ID: ENSMUSG00000025730 Description: Rab40C%2C member RAS oncogene family [Source:MGI Symbol;Acc:MGI:2183454] Location: 17:26101088-26138701 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Post-translational protein modification Rab44 Gene Information Basic Information Ensembl ID: ENSMUSG00000064147 Description: RAB44%2C member RAS oncogene family [Source:MGI Symbol;Acc:MGI:3045302] Location: 17:29333119-29367954 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell mast cell granulocyte basophil eosinophil Other: Innate Immune System Post-translational protein modification Rela Gene Information Basic Information Ensembl ID: ENSMUSG00000024927 Description: v-rel reticuloendotheliosis viral oncogene homolog A (avian) [Source:MGI Symbol;Acc:MGI:103290] Location: 19:5687511-5698158 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Ripk1 Gene Information Basic Information Ensembl ID: ENSMUSG00000021408 Description: receptor (TNFRSF)-interacting serine-threonine kinase 1 [Source:MGI Symbol;Acc:MGI:108212] Location: 13:34186346-34221130 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Apoptosis Innate Immune System Regulated Necrosis Ripk2 Gene Information Basic Information Ensembl ID: ENSMUSG00000041135 Description: receptor (TNFRSF)-interacting serine-threonine kinase 2 [Source:MGI Symbol;Acc:MGI:1891456] Location: 4:16122733-16163647 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Rnf128 Gene Information Basic Information Ensembl ID: ENSMUSG00000031438 Description: ring finger protein 128 [Source:MGI Symbol;Acc:MGI:1914139] Location: X:138464065-138573894 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Post-translational protein modification Sdc2 Gene Information Basic Information Ensembl ID: ENSMUSG00000022261 Description: syndecan 2 [Source:MGI Symbol;Acc:MGI:1349165] Location: 15:32920869-33035081 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte osteoblast mural cell Other: Metabolism of vitamins and cofactors Cell surface interactions at the vascular wall Visual phototransduction Smad2 Gene Information Basic Information Ensembl ID: ENSMUSG00000024563 Description: SMAD family member 2 [Source:MGI Symbol;Acc:MGI:108051] Location: 18:76374651-76444034 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Post-translational protein modification Signaling by NODAL RNA Polymerase II Transcription Smad3 Gene Information Basic Information Ensembl ID: ENSMUSG00000032402 Description: SMAD family member 3 [Source:MGI Symbol;Acc:MGI:1201674] Location: 9:63554049-63665276 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Specialized T cell Other: Signaling by NODAL Post-translational protein modification RNA Polymerase II Transcription Smad7 Gene Information Basic Information Ensembl ID: ENSMUSG00000025880 Description: SMAD family member 7 [Source:MGI Symbol;Acc:MGI:1100518] Location: 18:75500600-75529006 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: mast cell endothelial cell Other: Post-translational protein modification RNA Polymerase II Transcription Signaling by TGFB family members Smurf2 Gene Information Basic Information Ensembl ID: ENSMUSG00000018363 Description: SMAD specific E3 ubiquitin protein ligase 2 [Source:MGI Symbol;Acc:MGI:1913563] Location: 11:106710892-106811541 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Adaptive Immune System Signaling by WNT Signaling by Hedgehog Socs5 Gene Information Basic Information Ensembl ID: ENSMUSG00000037104 Description: suppressor of cytokine signaling 5 [Source:MGI Symbol;Acc:MGI:2385459] Location: 17:87415107-87445267 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Cytokine Signaling in Immune system Post-translational protein modification Spsb4 Gene Information Basic Information Ensembl ID: ENSMUSG00000046997 Description: splA/ryanodine receptor domain and SOCS box containing 4 [Source:MGI Symbol;Acc:MGI:2183445] Location: 9:96825535-96900896 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: progenitor cell Other: Post-translational protein modification Adaptive Immune System St8sia4 Gene Information Basic Information Ensembl ID: ENSMUSG00000040710 Description: ST8 alpha-N-acetyl-neuraminide alpha-2%2C8-sialyltransferase 4 [Source:MGI Symbol;Acc:MGI:106018] Location: 1:95515407-95595296 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell endothelial cell dendritic cell myeloid progenitor cell Other: Post-translational protein modification Nervous system development Tgfbr1 Gene Information Basic Information Ensembl ID: ENSMUSG00000007613 Description: transforming growth factor%2C beta receptor I [Source:MGI Symbol;Acc:MGI:98728] Location: 4:47353222-47414931 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte microglia Other: Post-translational protein modification Signaling by TGFB family members Thbs1 Gene Information Basic Information Ensembl ID: ENSMUSG00000040152 Description: thrombospondin 1 [Source:MGI Symbol;Acc:MGI:98737] Location: 2:117942357-117957614 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell fibroblast phagocyte epithelial cell monocyte mural cell megakaryocyte dendritic cell Other: Integrin cell surface interactions Post-translational protein modification Platelet activation, signaling and aggregation Thy1 Gene Information Basic Information Ensembl ID: ENSMUSG00000032011 Description: thymus cell antigen 1%2C theta [Source:MGI Symbol;Acc:MGI:98747] Location: 9:43954681-43959876 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell natural killer cell CD8+ T cell pericyte developing T cell CD4+ T cell interneuron stromal cell hematopoietic stem cell mesenchymal cell mesenchymal stem cell fibroblast innate lymphoid cell progenitor cell stem cell marginal B cell Other: Post-translational protein modification Tnc Gene Information Basic Information Ensembl ID: ENSMUSG00000028364 Description: tenascin C [Source:MGI Symbol;Acc:MGI:101922] Location: 4:63878022-63965252 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell fibroblast epithelial cell glial cell smooth muscle cell Other: Integrin cell surface interactions ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Traf2 Gene Information Basic Information Ensembl ID: ENSMUSG00000026942 Description: TNF receptor-associated factor 2 [Source:MGI Symbol;Acc:MGI:101835] Location: 2:25407994-25436952 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System Traf3 Gene Information Basic Information Ensembl ID: ENSMUSG00000021277 Description: TNF receptor-associated factor 3 [Source:MGI Symbol;Acc:MGI:108041] Location: 12:111132804-111233587 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Cytokine Signaling in Immune system Innate Immune System Post-translational protein modification Traf6 Gene Information Basic Information Ensembl ID: ENSMUSG00000027164 Description: TNF receptor-associated factor 6 [Source:MGI Symbol;Acc:MGI:108072] Location: 2:101508774-101532014 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Post-translational protein modification Cytokine Signaling in Immune system Adaptive Immune System Ube2g2 Gene Information Basic Information Ensembl ID: ENSMUSG00000009293 Description: ubiquitin-conjugating enzyme E2G 2 [Source:MGI Symbol;Acc:MGI:1343188] Location: 10:77458109-77481827 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Adaptive Immune System Post-translational protein modification Usp18 Gene Information Basic Information Ensembl ID: ENSMUSG00000030107 Description: ubiquitin specific peptidase 18 [Source:MGI Symbol;Acc:MGI:1344364] Location: 6:121222865-121247876 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Cytokine Signaling in Immune system Innate Immune System Post-translational protein modification Usp20 Gene Information Basic Information Ensembl ID: ENSMUSG00000026854 Description: ubiquitin specific peptidase 20 [Source:MGI Symbol;Acc:MGI:1921520] Location: 2:30872291-30913598 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Post-translational protein modification Usp29 Gene Information Basic Information Ensembl ID: ENSMUSG00000051527 Description: ubiquitin specific peptidase 29 [Source:MGI Symbol;Acc:MGI:1888998] Location: 7:6733577-6970218 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: excitatory neuron interneuron Other: Post-translational protein modification Usp4 Gene Information Basic Information Ensembl ID: ENSMUSG00000032612 Description: ubiquitin specific peptidase 4 (proto-oncogene) [Source:MGI Symbol;Acc:MGI:98905] Location: 9:108225052-108269744 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Post-translational protein modification Death Receptor Signaling Vnn1 Gene Information Basic Information Ensembl ID: ENSMUSG00000037440 Description: vanin 1 [Source:MGI Symbol;Acc:MGI:108395] Location: 10:23770586-23781241 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Metabolism of vitamins and cofactors Post-translational protein modification
Potassium Channels Pathway Hierarchies & Genes Activation of G protein gated Potassium channels (2 genes) Neuronal System Potassium Channels Inwardly rectifying K+ channels G protein gated Potassium channels Activation of G protein gated Potassium channels 2 genes ATP sensitive Potassium channels (1 genes) Neuronal System Potassium Channels Inwardly rectifying K+ channels ATP sensitive Potassium channels 1 genes Ca2+ activated K+ channels (1 genes) Neuronal System Potassium Channels Ca2+ activated K+ channels 1 genes	Gabbr1 Gene Information Basic Information Ensembl ID: ENSMUSG00000024462 Description: gamma-aminobutyric acid type B receptor subunit 1 [Source:MGI Symbol;Acc:MGI:1860139] Location: 17:37356858-37385959 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Transmission across Chemical Synapses Potassium Channels Signaling by GPCR Gngt2 Gene Information Basic Information Ensembl ID: ENSMUSG00000038811 Description: guanine nucleotide binding protein (G protein)%2C gamma transducing activity polypeptide 2 [Source:MGI Symbol;Acc:MGI:893584] Location: 11:95728042-95736560 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell dendritic cell phagocyte monocyte myeloid cell plasma cell macrophage photoreceptor cell Other: Platelet homeostasis Transmission across Chemical Synapses Potassium Channels Kcnj8 Gene Information Basic Information Ensembl ID: ENSMUSG00000030247 Description: potassium inwardly-rectifying channel%2C subfamily J%2C member 8 [Source:MGI Symbol;Acc:MGI:1100508] Location: 6:142510563-142517340 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte Other: Potassium Channels Kcnn4 Gene Information Basic Information Ensembl ID: ENSMUSG00000054342 Description: potassium intermediate/small conductance calcium-activated channel%2C subfamily N%2C member 4 [Source:MGI Symbol;Acc:MGI:1277957] Location: 7:24069688-24086115 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Regulatory T cell hematopoietic progenitor cell plasma cell Other: Potassium Channels
Prednisone ADME Pathway Hierarchies & Genes Prednisone ADME (1 genes) Drug ADME Prednisone ADME 1 genes	Ugt2b34 Gene Information Basic Information Ensembl ID: ENSMUSG00000029260 Description: UDP glucuronosyltransferase 2 family%2C polypeptide B34 [Source:MGI Symbol;Acc:MGI:2140962] Location: 5:87037626-87054796 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Biological oxidations Aspirin ADME Paracetamol ADME
Processing of Capped Intron-Containing Pre-mRNA Pathway Hierarchies & Genes mRNA 3'-end processing (1 genes) Metabolism of RNA Processing of Capped Intron-Containing Pre-mRNA Transport of Mature Transcript to Cytoplasm Transport of Mature mRNAs Derived from Intronless Transcripts Transport of the SLBP independent Mature mRNA mRNA Splicing mRNA Splicing - Major Pathway mRNA 3'-end processing 1 genes mRNA 3'-end processing (1 genes) Metabolism of RNA Processing of Capped Intron-Containing Pre-mRNA Transport of Mature Transcript to Cytoplasm Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing mRNA Splicing - Major Pathway mRNA 3'-end processing 1 genes Transport of the SLBP independent Mature mRNA (1 genes) Metabolism of RNA Processing of Capped Intron-Containing Pre-mRNA Transport of Mature Transcript to Cytoplasm Transport of Mature mRNAs Derived from Intronless Transcripts Transport of the SLBP independent Mature mRNA 1 genes mRNA Splicing - Major Pathway (1 genes) Metabolism of RNA Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway 1 genes	Alyref Gene Information Basic Information Ensembl ID: ENSMUSG00000025134 Description: Aly/REF export factor [Source:MGI Symbol;Acc:MGI:1341044] Location: 11:120482947-120489191 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stromal cell skeletal muscle cell bone cell Other: Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Ddx39b Gene Information Basic Information Ensembl ID: ENSMUSG00000019432 Description: DEAD box helicase 39b [Source:MGI Symbol;Acc:MGI:99240] Location: 17:35460722-35472683 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: progenitor cell skeletal muscle cell Other: Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Nup85 Gene Information Basic Information Ensembl ID: ENSMUSG00000020739 Description: nucleoporin 85 [Source:MGI Symbol;Acc:MGI:3046173] Location: 11:115455260-115474811 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: bone cell Other: Metabolism of non-coding RNA Gene Silencing by RNA Cellular responses to stress Pnn Gene Information Basic Information Ensembl ID: ENSMUSG00000020994 Description: pinin [Source:MGI Symbol;Acc:MGI:1100514] Location: 12:59113670-59120784 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell Other: Processing of Capped Intron-Containing Pre-mRNA
Protein folding Pathway Hierarchies & Genes Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding (4 genes) Metabolism of proteins Protein folding Chaperonin-mediated protein folding Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 4 genes	Gna11 Gene Information Basic Information Ensembl ID: ENSMUSG00000034781 Description: guanine nucleotide binding protein%2C alpha 11 [Source:MGI Symbol;Acc:MGI:95766] Location: 10:81364558-81381024 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell endothelial cell enterocyte Other: Integration of energy metabolism Signaling by GPCR Protein folding Gna14 Gene Information Basic Information Ensembl ID: ENSMUSG00000024697 Description: guanine nucleotide binding protein%2C alpha 14 [Source:MGI Symbol;Acc:MGI:95769] Location: 19:16413126-16588184 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell epithelial cell Other: Integration of energy metabolism Signaling by GPCR Protein folding Gnaq Gene Information Basic Information Ensembl ID: ENSMUSG00000024639 Description: guanine nucleotide binding protein%2C alpha q polypeptide [Source:MGI Symbol;Acc:MGI:95776] Location: 19:16110195-16364827 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: antigen presenting cell Other: Integration of energy metabolism Signaling by GPCR Protein folding Gngt2 Gene Information Basic Information Ensembl ID: ENSMUSG00000038811 Description: guanine nucleotide binding protein (G protein)%2C gamma transducing activity polypeptide 2 [Source:MGI Symbol;Acc:MGI:893584] Location: 11:95728042-95736560 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell dendritic cell phagocyte monocyte myeloid cell plasma cell macrophage photoreceptor cell Other: Platelet homeostasis Transmission across Chemical Synapses Potassium Channels
Protein-protein interactions at synapses Pathway Hierarchies & Genes Synaptic adhesion-like molecules (10 genes) Neuronal System Protein-protein interactions at synapses Neurexins and neuroligins 8 genes Synaptic adhesion-like molecules 2 genes Receptor-type tyrosine-protein phosphatases (3 genes) Neuronal System Protein-protein interactions at synapses Receptor-type tyrosine-protein phosphatases 3 genes Synaptic adhesion-like molecules (2 genes) Neuronal System Protein-protein interactions at synapses Synaptic adhesion-like molecules 2 genes	Dlg1 Gene Information Basic Information Ensembl ID: ENSMUSG00000022770 Description: discs large MAGUK scaffold protein 1 [Source:MGI Symbol;Acc:MGI:107231] Location: 16:31482261-31693947 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell ectodermal cell Other: Transmission across Chemical Synapses MAPK family signaling cascades Protein-protein interactions at synapses Dlg2 Gene Information Basic Information Ensembl ID: ENSMUSG00000052572 Description: discs large MAGUK scaffold protein 2 [Source:MGI Symbol;Acc:MGI:1344351] Location: 7:90125880-92098455 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron epithelial cell Other: Transmission across Chemical Synapses MAPK family signaling cascades Protein-protein interactions at synapses Dlg3 Gene Information Basic Information Ensembl ID: ENSMUSG00000000881 Description: discs large MAGUK scaffold protein 3 [Source:MGI Symbol;Acc:MGI:1888986] Location: X:99811328-99862016 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Transmission across Chemical Synapses MAPK family signaling cascades Protein-protein interactions at synapses Dlg4 Gene Information Basic Information Ensembl ID: ENSMUSG00000020886 Description: discs large MAGUK scaffold protein 4 [Source:MGI Symbol;Acc:MGI:1277959] Location: 11:69907768-69938348 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: photoreceptor cell Other: Transmission across Chemical Synapses LGI-ADAM interactions MAPK family signaling cascades Gria1 Gene Information Basic Information Ensembl ID: ENSMUSG00000020524 Description: glutamate receptor%2C ionotropic%2C AMPA1 (alpha 1) [Source:MGI Symbol;Acc:MGI:95808] Location: 11:56902213-57221070 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: bergmann glial cell neuron Other: Transmission across Chemical Synapses Membrane Trafficking Post-translational protein modification Grm5 Gene Information Basic Information Ensembl ID: ENSMUSG00000049583 Description: glutamate receptor%2C metabotropic 5 [Source:MGI Symbol;Acc:MGI:1351342] Location: 7:87233376-87784115 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Signaling by GPCR Protein-protein interactions at synapses Homer1 Gene Information Basic Information Ensembl ID: ENSMUSG00000007617 Description: homer scaffolding protein 1 [Source:MGI Symbol;Acc:MGI:1347345] Location: 13:93436143-93541637 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Protein-protein interactions at synapses Homer2 Gene Information Basic Information Ensembl ID: ENSMUSG00000025813 Description: homer scaffolding protein 2 [Source:MGI Symbol;Acc:MGI:1347354] Location: 7:81250229-81357275 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell cajal-retzius cell club skeletal muscle cell Other: Protein-protein interactions at synapses Homer3 Gene Information Basic Information Ensembl ID: ENSMUSG00000003573 Description: homer scaffolding protein 3 [Source:MGI Symbol;Acc:MGI:1347359] Location: 8:70735477-70747011 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Protein-protein interactions at synapses Il1rap Gene Information Basic Information Ensembl ID: ENSMUSG00000022514 Description: interleukin 1 receptor accessory protein [Source:MGI Symbol;Acc:MGI:104975] Location: 16:26400454-26548867 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell bipolar cell neuron Other: Cytokine Signaling in Immune system Protein-protein interactions at synapses Intracellular signaling by second messengers Il1rapl1 Gene Information Basic Information Ensembl ID: ENSMUSG00000052372 Description: interleukin 1 receptor accessory protein-like 1 [Source:MGI Symbol;Acc:MGI:2687319] Location: X:85784476-87159251 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron glial cell epithelial cell interneuron oligodendrocyte precursor cell Other: Protein-protein interactions at synapses Cytokine Signaling in Immune system Il1rapl2 Gene Information Basic Information Ensembl ID: ENSMUSG00000059203 Description: interleukin 1 receptor accessory protein-like 2 [Source:MGI Symbol;Acc:MGI:1913106] Location: X:136471357-137747695 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Protein-protein interactions at synapses Nrxn1 Gene Information Basic Information Ensembl ID: ENSMUSG00000024109 Description: neurexin I [Source:MGI Symbol;Acc:MGI:1096391] Location: 17:90341059-91400499 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron stellate cell Other: Protein-protein interactions at synapses Shank1 Gene Information Basic Information Ensembl ID: ENSMUSG00000038738 Description: SH3 and multiple ankyrin repeat domains 1 [Source:MGI Symbol;Acc:MGI:3613677] Location: 7:43959677-44009996 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Protein-protein interactions at synapses Shank3 Gene Information Basic Information Ensembl ID: ENSMUSG00000022623 Description: SH3 and multiple ankyrin repeat domains 3 [Source:MGI Symbol;Acc:MGI:1930016] Location: 15:89383826-89444464 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Protein-protein interactions at synapses Nervous system development
RNA Polymerase II Transcription Pathway Hierarchies & Genes PI5P Regulates TP53 Acetylation (1 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional Regulation by TP53 Regulation of TP53 Activity Regulation of TP53 Activity through Acetylation PI5P Regulates TP53 Acetylation 1 genes Regulation of TP53 Degradation (3 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional Regulation by TP53 Regulation of TP53 Activity Regulation of TP53 Expression and Degradation Regulation of TP53 Degradation 3 genes Regulation of TP53 Activity through Association with Co-factors (1 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional Regulation by TP53 Regulation of TP53 Activity Regulation of TP53 Activity through Association with Co-factors 1 genes FOXO-mediated transcription of cell cycle genes (1 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway FOXO-mediated transcription FOXO-mediated transcription of cell cycle genes 1 genes NPAS4 regulates expression of target genes (1 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional Regulation by NPAS4 NPAS4 regulates expression of target genes 1 genes RUNX1 regulates transcription of genes involved in differentiation of HSCs (2 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional regulation by RUNX1 RUNX1 regulates transcription of genes involved in differentiation of HSCs 2 genes RUNX3 regulates CDKN1A transcription (2 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional regulation by RUNX3 RUNX3 regulates CDKN1A transcription 2 genes RUNX3 regulates NOTCH signaling (2 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional regulation by RUNX3 RUNX3 regulates NOTCH signaling 2 genes RUNX3 regulates WNT signaling (2 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional regulation by RUNX3 RUNX3 regulates WNT signaling 2 genes Regulation of RUNX1 Expression and Activity (1 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional regulation by RUNX1 Regulation of RUNX1 Expression and Activity 1 genes Regulation of RUNX2 expression and activity (1 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional regulation by RUNX2 Regulation of RUNX2 expression and activity 1 genes Regulation of RUNX3 expression and activity (2 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional regulation by RUNX3 Regulation of RUNX3 expression and activity 2 genes TFAP2 (AP-2) family regulates transcription of cell cycle factors (1 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors TFAP2 (AP-2) family regulates transcription of cell cycle factors 1 genes TFAP2 (AP-2) family regulates transcription of growth factors and their receptors (1 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 1 genes TP53 Regulates Metabolic Genes (3 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional Regulation by TP53 TP53 Regulates Metabolic Genes 3 genes Nuclear Receptor transcription pathway (2 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Nuclear Receptor transcription pathway 2 genes Transcriptional regulation by RUNX2 (1 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional regulation by RUNX2 1 genes Generic Transcription Pathway (2 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway 2 genes RNA Polymerase II Transcription Termination (2 genes) Gene expression (Transcription) RNA Polymerase II Transcription RNA Polymerase II Transcription Termination 2 genes RNA polymerase II transcribes snRNA genes (1 genes) Gene expression (Transcription) RNA Polymerase II Transcription RNA polymerase II transcribes snRNA genes 1 genes	Abl1 Gene Information Basic Information Ensembl ID: ENSMUSG00000026842 Description: c-abl oncogene 1%2C non-receptor tyrosine kinase [Source:MGI Symbol;Acc:MGI:87859] Location: 2:31578388-31694239 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Epigenetic regulation of gene expression Myogenesis Alyref Gene Information Basic Information Ensembl ID: ENSMUSG00000025134 Description: Aly/REF export factor [Source:MGI Symbol;Acc:MGI:1341044] Location: 11:120482947-120489191 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stromal cell skeletal muscle cell bone cell Other: Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Cdk1 Gene Information Basic Information Ensembl ID: ENSMUSG00000019942 Description: cyclin dependent kinase 1 [Source:MGI Symbol;Acc:MGI:88351] Location: 10:69170976-69188768 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: proliferative cell Other: Cytokine Signaling in Immune system Cilium Assembly MAPK family signaling cascades Ctnnb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000006932 Description: catenin beta 1 [Source:MGI Symbol;Acc:MGI:88276] Location: 9:120758282-120789573 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stem cell epithelial cell Other: Apoptosis Innate Immune System Signaling by WNT Ddx39b Gene Information Basic Information Ensembl ID: ENSMUSG00000019432 Description: DEAD box helicase 39b [Source:MGI Symbol;Acc:MGI:99240] Location: 17:35460722-35472683 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: progenitor cell skeletal muscle cell Other: Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Esr1 Gene Information Basic Information Ensembl ID: ENSMUSG00000019768 Description: estrogen receptor 1 (alpha) [Source:MGI Symbol;Acc:MGI:1352467] Location: 10:4561593-4955614 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by Receptor Tyrosine Kinases Cellular responses to stress Post-translational protein modification Gata3 Gene Information Basic Information Ensembl ID: ENSMUSG00000015619 Description: GATA binding protein 3 [Source:MGI Symbol;Acc:MGI:95663] Location: 2:9861889-9894845 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Regulatory T cell epithelial cell stem cell CD4+ T cell innate lymphoid cell developing T cell mesangial cell Other: Post-translational protein modification RNA Polymerase II Transcription Signaling by Nuclear Receptors Gsr Gene Information Basic Information Ensembl ID: ENSMUSG00000031584 Description: glutathione reductase [Source:MGI Symbol;Acc:MGI:95804] Location: 8:34142551-34188191 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: myeloid cell neutrophil myeloid derived suppressor cell immune cell Other: Metabolism of nucleotides Cellular responses to stress RNA Polymerase II Transcription Maged1 Gene Information Basic Information Ensembl ID: ENSMUSG00000025151 Description: MAGE family member D1 [Source:MGI Symbol;Acc:MGI:1930187] Location: X:93579080-93585749 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endocrine cell fibroblast stromal cell epithelial cell retina cell glial cell Other: RNA Polymerase II Transcription Map2k6 Gene Information Basic Information Ensembl ID: ENSMUSG00000020623 Description: mitogen-activated protein kinase kinase 6 [Source:MGI Symbol;Acc:MGI:1346870] Location: 11:110289948-110416348 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: bergmann glial cell skeletal muscle cell Other: Cytokine Signaling in Immune system Innate Immune System Cellular responses to stress Med1 Gene Information Basic Information Ensembl ID: ENSMUSG00000018160 Description: mediator complex subunit 1 [Source:MGI Symbol;Acc:MGI:1100846] Location: 11:98042980-98084119 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cellular responses to stress Metabolism of lipids RNA Polymerase II Transcription Men1 Gene Information Basic Information Ensembl ID: ENSMUSG00000024947 Description: multiple endocrine neoplasia 1 [Source:MGI Symbol;Acc:MGI:1316736] Location: 19:6385009-6390921 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by WNT Epigenetic regulation of gene expression Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Myc Gene Information Basic Information Ensembl ID: ENSMUSG00000022346 Description: myelocytomatosis oncogene [Source:MGI Symbol;Acc:MGI:97250] Location: 15:61857240-61862223 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Post-translational protein modification RNA Polymerase II Transcription Notch1 Gene Information Basic Information Ensembl ID: ENSMUSG00000026923 Description: notch 1 [Source:MGI Symbol;Acc:MGI:97363] Location: 2:26347915-26406675 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell neuron CD4+ T cell epithelial cell smooth muscle cell T cell Other: Signaling by NOTCH RNA Polymerase II Transcription Pou2f2 Gene Information Basic Information Ensembl ID: ENSMUSG00000008496 Description: POU domain%2C class 2%2C transcription factor 2 [Source:MGI Symbol;Acc:MGI:101897] Location: 7:24786769-24879151 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Naive B cell microglia monocyte antigen presenting cell memory B cell Other: RNA Polymerase II Transcription Ppard Gene Information Basic Information Ensembl ID: ENSMUSG00000002250 Description: peroxisome proliferator activator receptor delta [Source:MGI Symbol;Acc:MGI:101884] Location: 17:28451674-28520448 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Metabolism of lipids RNA Polymerase II Transcription Signaling by Nuclear Receptors Ppp2ca Gene Information Basic Information Ensembl ID: ENSMUSG00000020349 Description: protein phosphatase 2 (formerly 2A)%2C catalytic subunit%2C alpha isoform [Source:MGI Symbol;Acc:MGI:1321159] Location: 11:51989508-52018605 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Prr5 Gene Information Basic Information Ensembl ID: ENSMUSG00000036106 Description: proline rich 5 (renal) [Source:MGI Symbol;Acc:MGI:1924714] Location: 15:84553821-84587874 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: plasma cell Other: Adaptive Immune System RNA Polymerase II Transcription Intracellular signaling by second messengers Ptpn11 Gene Information Basic Information Ensembl ID: ENSMUSG00000043733 Description: protein tyrosine phosphatase%2C non-receptor type 11 [Source:MGI Symbol;Acc:MGI:99511] Location: 5:121268596-121329460 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Nervous system development Cytokine Signaling in Immune system Adaptive Immune System Rbpj Gene Information Basic Information Ensembl ID: ENSMUSG00000039191 Description: recombination signal binding protein for immunoglobulin kappa J region [Source:MGI Symbol;Acc:MGI:96522] Location: 5:53623494-53814704 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron phagocyte dendritic cell antigen presenting cell Other: Signaling by NOTCH RNA Polymerase II Transcription Rragd Gene Information Basic Information Ensembl ID: ENSMUSG00000028278 Description: Ras-related GTP binding D [Source:MGI Symbol;Acc:MGI:1098604] Location: 4:32983037-33022180 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Macroautophagy MTOR signalling Cellular responses to stress Smad2 Gene Information Basic Information Ensembl ID: ENSMUSG00000024563 Description: SMAD family member 2 [Source:MGI Symbol;Acc:MGI:108051] Location: 18:76374651-76444034 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Post-translational protein modification Signaling by NODAL RNA Polymerase II Transcription Smad3 Gene Information Basic Information Ensembl ID: ENSMUSG00000032402 Description: SMAD family member 3 [Source:MGI Symbol;Acc:MGI:1201674] Location: 9:63554049-63665276 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Specialized T cell Other: Signaling by NODAL Post-translational protein modification RNA Polymerase II Transcription Smad7 Gene Information Basic Information Ensembl ID: ENSMUSG00000025880 Description: SMAD family member 7 [Source:MGI Symbol;Acc:MGI:1100518] Location: 18:75500600-75529006 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: mast cell endothelial cell Other: Post-translational protein modification RNA Polymerase II Transcription Signaling by TGFB family members Smurf1 Gene Information Basic Information Ensembl ID: ENSMUSG00000038780 Description: SMAD specific E3 ubiquitin protein ligase 1 [Source:MGI Symbol;Acc:MGI:1923038] Location: 5:144813305-144902657 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Adaptive Immune System Signaling by WNT Signaling by Hedgehog Smurf2 Gene Information Basic Information Ensembl ID: ENSMUSG00000018363 Description: SMAD specific E3 ubiquitin protein ligase 2 [Source:MGI Symbol;Acc:MGI:1913563] Location: 11:106710892-106811541 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Adaptive Immune System Signaling by WNT Signaling by Hedgehog Sox9 Gene Information Basic Information Ensembl ID: ENSMUSG00000000567 Description: SRY (sex determining region Y)-box 9 [Source:MGI Symbol;Acc:MGI:98371] Location: 11:112673050-112678586 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell stromal cell tuft cell muscle cell chondrocyte bone cell progenitor cell hepatocyte natural killer cell stem cell Other: Signaling by WNT RNA Polymerase II Transcription Stub1 Gene Information Basic Information Ensembl ID: ENSMUSG00000039615 Description: STIP1 homology and U-Box containing protein 1 [Source:MGI Symbol;Acc:MGI:1891731] Location: 17:26049479-26052378 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Adaptive Immune System Regulated Necrosis RNA Polymerase II Transcription Tcf7l2 Gene Information Basic Information Ensembl ID: ENSMUSG00000024985 Description: transcription factor 7 like 2%2C T cell specific%2C HMG box [Source:MGI Symbol;Acc:MGI:1202879] Location: 19:55730252-55922086 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell fibroblast macrophage excitatory neuron mesenchymal cell oligodendrocyte Other: Signaling by WNT RNA Polymerase II Transcription MITF-M-regulated melanocyte development Tgfb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000002603 Description: transforming growth factor%2C beta 1 [Source:MGI Symbol;Acc:MGI:98725] Location: 7:25386427-25404502 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell hematopoietic stem cell phagocyte monocyte leukocyte megakaryocyte Other: Cell surface interactions at the vascular wall Non-integrin membrane-ECM interactions Elastic fibre formation Trp63 Gene Information Basic Information Ensembl ID: ENSMUSG00000022510 Description: transformation related protein 63 [Source:MGI Symbol;Acc:MGI:1330810] Location: 16:25502513-25710852 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell basal cell Other: RNA Polymerase II Transcription Tsc1 Gene Information Basic Information Ensembl ID: ENSMUSG00000026812 Description: TSC complex subunit 1 [Source:MGI Symbol;Acc:MGI:1929183] Location: 2:28531240-28581179 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Macroautophagy MTOR signalling Membrane Trafficking
Regulated Necrosis Pathway Hierarchies & Genes CASP8 activity is inhibited (7 genes) Programmed Cell Death Regulated Necrosis RIPK1-mediated regulated necrosis Regulation of necroptotic cell death CASP8 activity is inhibited 7 genes Regulation of necroptotic cell death (3 genes) Programmed Cell Death Regulated Necrosis RIPK1-mediated regulated necrosis Regulation of necroptotic cell death 3 genes Pyroptosis (6 genes) Programmed Cell Death Regulated Necrosis Pyroptosis 6 genes	Casp1 Gene Information Basic Information Ensembl ID: ENSMUSG00000025888 Description: caspase 1 [Source:MGI Symbol;Acc:MGI:96544] Location: 9:5298508-5307290 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Innate Immune System Regulated Necrosis Casp3 Gene Information Basic Information Ensembl ID: ENSMUSG00000031628 Description: caspase 3 [Source:MGI Symbol;Acc:MGI:107739] Location: 8:47070326-47092724 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell eosinophil Other: Apoptosis Cytokine Signaling in Immune system Signaling by Hippo Casp4 Gene Information Basic Information Ensembl ID: ENSMUSG00000033538 Description: caspase 4%2C apoptosis-related cysteine peptidase [Source:MGI Symbol;Acc:MGI:107700] Location: 9:5308828-5336783 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Regulated Necrosis Casp8 Gene Information Basic Information Ensembl ID: ENSMUSG00000026029 Description: caspase 8 [Source:MGI Symbol;Acc:MGI:1261423] Location: 1:58834533-58886662 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System Fadd Gene Information Basic Information Ensembl ID: ENSMUSG00000031077 Description: Fas associated via death domain [Source:MGI Symbol;Acc:MGI:109324] Location: 7:144131055-144136200 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Apoptosis Innate Immune System Regulated Necrosis Fasl Gene Information Basic Information Ensembl ID: ENSMUSG00000000817 Description: Fas ligand [Source:MGI Symbol;Acc:MGI:99255] Location: 1:161608258-161616064 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell CD8+ T cell T cell Other: Apoptosis Regulated Necrosis Death Receptor Signaling Gzmb Gene Information Basic Information Ensembl ID: ENSMUSG00000015437 Description: granzyme B [Source:MGI Symbol;Acc:MGI:109267] Location: 14:56496295-56499717 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell CD8+ T cell Other: Apoptosis Regulated Necrosis Il1a Gene Information Basic Information Ensembl ID: ENSMUSG00000027399 Description: interleukin 1 alpha [Source:MGI Symbol;Acc:MGI:96542] Location: 2:129141530-129151892 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte Other: Cytokine Signaling in Immune system Regulated Necrosis Il1b Gene Information Basic Information Ensembl ID: ENSMUSG00000027398 Description: interleukin 1 beta [Source:MGI Symbol;Acc:MGI:96543] Location: 2:129206490-129213059 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell dendritic cell phagocyte granulocyte myeloid cell erythroid lineage cell T cell leukocyte macrophage Other: Cytokine Signaling in Immune system Innate Immune System Regulated Necrosis Mlkl Gene Information Basic Information Ensembl ID: ENSMUSG00000012519 Description: mixed lineage kinase domain-like [Source:MGI Symbol;Acc:MGI:1921818] Location: 8:112038429-112064809 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Regulated Necrosis Ion channel transport Prkn Gene Information Basic Information Ensembl ID: ENSMUSG00000023826 Description: parkin RBR E3 ubiquitin protein ligase [Source:MGI Symbol;Acc:MGI:1355296] Location: 17:11059271-12282248 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Adaptive Immune System Macroautophagy Regulated Necrosis Ripk1 Gene Information Basic Information Ensembl ID: ENSMUSG00000021408 Description: receptor (TNFRSF)-interacting serine-threonine kinase 1 [Source:MGI Symbol;Acc:MGI:108212] Location: 13:34186346-34221130 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Apoptosis Innate Immune System Regulated Necrosis Stub1 Gene Information Basic Information Ensembl ID: ENSMUSG00000039615 Description: STIP1 homology and U-Box containing protein 1 [Source:MGI Symbol;Acc:MGI:1891731] Location: 17:26049479-26052378 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Adaptive Immune System Regulated Necrosis RNA Polymerase II Transcription Tnfrsf10b Gene Information Basic Information Ensembl ID: ENSMUSG00000022074 Description: tumor necrosis factor receptor superfamily%2C member 10b [Source:MGI Symbol;Acc:MGI:1341090] Location: 14:70004921-70021860 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Apoptosis Cell surface interactions at the vascular wall Regulated Necrosis Tnfsf10 Gene Information Basic Information Ensembl ID: ENSMUSG00000039304 Description: tumor necrosis factor (ligand) superfamily%2C member 10 [Source:MGI Symbol;Acc:MGI:107414] Location: 3:27371177-27396576 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Apoptosis Regulated Necrosis Death Receptor Signaling Traf2 Gene Information Basic Information Ensembl ID: ENSMUSG00000026942 Description: TNF receptor-associated factor 2 [Source:MGI Symbol;Acc:MGI:101835] Location: 2:25407994-25436952 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Apoptosis Cytokine Signaling in Immune system Innate Immune System
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway Hierarchies & Genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (11 genes) Metabolism of proteins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 11 genes	Bmp4 Gene Information Basic Information Ensembl ID: ENSMUSG00000021835 Description: bone morphogenetic protein 4 [Source:MGI Symbol;Acc:MGI:88180] Location: 14:46620977-46628126 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stem cell fibroblast epithelial cell smooth muscle cell ectodermal cell endothelial cell mesodermal cell Other: Elastic fibre formation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein modification Ccn1 Gene Information Basic Information Ensembl ID: ENSMUSG00000028195 Description: cellular communication network factor 1 [Source:MGI Symbol;Acc:MGI:88613] Location: 3:145352731-145355736 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stem cell endothelial cell epithelial cell fibroblast astrocyte Other: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein modification Cdh2 Gene Information Basic Information Ensembl ID: ENSMUSG00000024304 Description: cadherin 2 [Source:MGI Symbol;Acc:MGI:88355] Location: 18:16721934-16942303 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte stellate cell glial cell skeletal muscle cell motor neuron osteoblast epithelial cell Other: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cell junction organization Myogenesis Ckap4 Gene Information Basic Information Ensembl ID: ENSMUSG00000046841 Description: cytoskeleton-associated protein 4 [Source:MGI Symbol;Acc:MGI:2444926] Location: 10:84362169-84369926 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell fibroblast smooth muscle cell granulocyte epithelial cell osteoblast Other: Innate Immune System Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Surfactant metabolism Csf1 Gene Information Basic Information Ensembl ID: ENSMUSG00000014599 Description: colony stimulating factor 1 (macrophage) [Source:MGI Symbol;Acc:MGI:1339753] Location: 3:107648364-107667785 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell endothelial cell basophil eosinophil Other: Cytokine Signaling in Immune system Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein modification Fam20c Gene Information Basic Information Ensembl ID: ENSMUSG00000025854 Description: FAM20C%2C golgi associated secretory pathway kinase [Source:MGI Symbol;Acc:MGI:2136853] Location: 5:138740269-138795832 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein modification Gpc3 Gene Information Basic Information Ensembl ID: ENSMUSG00000055653 Description: glypican 3 [Source:MGI Symbol;Acc:MGI:104903] Location: X:51361303-51702827 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell stromal cell embryonic cell fibroblast epithelial cell Other: Metabolism of vitamins and cofactors Visual phototransduction Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Men1 Gene Information Basic Information Ensembl ID: ENSMUSG00000024947 Description: multiple endocrine neoplasia 1 [Source:MGI Symbol;Acc:MGI:1316736] Location: 19:6385009-6390921 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by WNT Epigenetic regulation of gene expression Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Msln Gene Information Basic Information Ensembl ID: ENSMUSG00000063011 Description: mesothelin [Source:MGI Symbol;Acc:MGI:1888992] Location: 17:25967587-25973352 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell fibroblast pneumocyte mesothelial cell Other: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein modification Sdc2 Gene Information Basic Information Ensembl ID: ENSMUSG00000022261 Description: syndecan 2 [Source:MGI Symbol;Acc:MGI:1349165] Location: 15:32920869-33035081 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte osteoblast mural cell Other: Metabolism of vitamins and cofactors Cell surface interactions at the vascular wall Visual phototransduction Tnc Gene Information Basic Information Ensembl ID: ENSMUSG00000028364 Description: tenascin C [Source:MGI Symbol;Acc:MGI:101922] Location: 4:63878022-63965252 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell fibroblast epithelial cell glial cell smooth muscle cell Other: Integrin cell surface interactions ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Regulation of mRNA stability by proteins that bind AU-rich elements Pathway Hierarchies & Genes Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA (1 genes) Metabolism of RNA Regulation of mRNA stability by proteins that bind AU-rich elements Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 1 genes	Zfp36 Gene Information Basic Information Ensembl ID: ENSMUSG00000044786 Description: zinc finger protein 36 [Source:MGI Symbol;Acc:MGI:99180] Location: 7:28076209-28079678 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell endothelial cell stem cell phagocyte epithelial cell granulocyte basophil erythroblast pancreatic cell Other: Regulation of mRNA stability by proteins that bind AU-rich elements
Reversible hydration of carbon dioxide Pathway Hierarchies & Genes Reversible hydration of carbon dioxide (1 genes) Metabolism Reversible hydration of carbon dioxide 1 genes	Car2 Gene Information Basic Information Ensembl ID: ENSMUSG00000027562 Description: carbonic anhydrase 2 [Source:MGI Symbol;Acc:MGI:88269] Location: 3:14951333-14965830 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell kidney cell stem cell hematopoietic stem cell erythrocyte glial cell intercalated cell smooth muscle cell hematopoietic progenitor cell erythroid lineage cell ductal cell Other: Reversible hydration of carbon dioxide O2/CO2 exchange in erythrocytes
SLC-mediated transmembrane transport Pathway Hierarchies & Genes Organic anion transport (2 genes) Transport of small molecules SLC-mediated transmembrane transport Transport of bile salts and organic acids, metal ions and amine compounds Organic cation/anion/zwitterion transport Organic anion transport 2 genes Amino acid transport across the plasma membrane (1 genes) Transport of small molecules SLC-mediated transmembrane transport Transport of inorganic cations/anions and amino acids/oligopeptides Amino acid transport across the plasma membrane 1 genes Metal ion SLC transporters (2 genes) Transport of small molecules SLC-mediated transmembrane transport Transport of bile salts and organic acids, metal ions and amine compounds Metal ion SLC transporters 2 genes Na+/Cl- dependent neurotransmitter transporters (1 genes) Transport of small molecules SLC-mediated transmembrane transport Transport of bile salts and organic acids, metal ions and amine compounds Na+/Cl- dependent neurotransmitter transporters 1 genes Organic anion transporters (1 genes) Transport of small molecules SLC-mediated transmembrane transport Transport of inorganic cations/anions and amino acids/oligopeptides Organic anion transporters 1 genes Proton-coupled monocarboxylate transport (1 genes) Transport of small molecules SLC-mediated transmembrane transport Transport of bile salts and organic acids, metal ions and amine compounds Proton-coupled monocarboxylate transport 1 genes Sodium-coupled sulphate, di- and tri-carboxylate transporters (1 genes) Transport of small molecules SLC-mediated transmembrane transport Transport of bile salts and organic acids, metal ions and amine compounds Sodium-coupled sulphate, di- and tri-carboxylate transporters 1 genes Transport of fatty acids (2 genes) Transport of small molecules SLC-mediated transmembrane transport Transport of vitamins, nucleosides, and related molecules Transport of fatty acids 2 genes Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (1 genes) Transport of small molecules SLC-mediated transmembrane transport Transport of vitamins, nucleosides, and related molecules Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 1 genes Transport of organic anions (2 genes) Transport of small molecules SLC-mediated transmembrane transport Transport of vitamins, nucleosides, and related molecules Transport of organic anions 2 genes Cellular hexose transport (1 genes) Transport of small molecules SLC-mediated transmembrane transport Cellular hexose transport 1 genes Transport of bile salts and organic acids, metal ions and amine compounds (1 genes) Transport of small molecules SLC-mediated transmembrane transport Transport of bile salts and organic acids, metal ions and amine compounds 1 genes	Arl2bp Gene Information Basic Information Ensembl ID: ENSMUSG00000031776 Description: ADP-ribosylation factor-like 2 binding protein [Source:MGI Symbol;Acc:MGI:1349429] Location: 8:95393228-95401053 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: SLC-mediated transmembrane transport Emb Gene Information Basic Information Ensembl ID: ENSMUSG00000021728 Description: embigin [Source:MGI Symbol;Acc:MGI:95321] Location: 13:117345072-117410951 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell developing T cell hematopoietic stem cell stem cell dendritic cell leukocyte granulocyte monocyte Other: SLC-mediated transmembrane transport Slc11a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000026177 Description: solute carrier family 11 (proton-coupled divalent metal ion transporters)%2C member 1 [Source:MGI Symbol;Acc:MGI:1345275] Location: 1:74414354-74425221 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte monocyte myeloid cell Other: Innate Immune System SLC-mediated transmembrane transport Slc13a5 Gene Information Basic Information Ensembl ID: ENSMUSG00000020805 Description: solute carrier family 13 (sodium-dependent citrate transporter)%2C member 5 [Source:MGI Symbol;Acc:MGI:3037150] Location: 11:72132815-72158048 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: osteoblast Other: SLC-mediated transmembrane transport Slc18a2 Gene Information Basic Information Ensembl ID: ENSMUSG00000025094 Description: solute carrier family 18 (vesicular monoamine)%2C member 2 [Source:MGI Symbol;Acc:MGI:106677] Location: 19:59249328-59284444 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: mast cell modulatory neuron neuron Other: Transmission across Chemical Synapses SLC-mediated transmembrane transport Slc22a7 Gene Information Basic Information Ensembl ID: ENSMUSG00000067144 Description: solute carrier family 22 (organic anion transporter)%2C member 7 [Source:MGI Symbol;Acc:MGI:1859559] Location: 17:46743109-46749383 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: tuft cell Other: SLC-mediated transmembrane transport Aspirin ADME Slc22a8 Gene Information Basic Information Ensembl ID: ENSMUSG00000063796 Description: solute carrier family 22 (organic anion transporter)%2C member 8 [Source:MGI Symbol;Acc:MGI:1336187] Location: 19:8568618-8589199 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell epithelial cell Other: SLC-mediated transmembrane transport Slc27a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000031808 Description: solute carrier family 27 (fatty acid transporter)%2C member 1 [Source:MGI Symbol;Acc:MGI:1347098] Location: 8:72021526-72039946 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: SLC-mediated transmembrane transport Slc27a4 Gene Information Basic Information Ensembl ID: ENSMUSG00000059316 Description: solute carrier family 27 (fatty acid transporter)%2C member 4 [Source:MGI Symbol;Acc:MGI:1347347] Location: 2:29692646-29707534 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: SLC-mediated transmembrane transport Slc2a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000028645 Description: solute carrier family 2 (facilitated glucose transporter)%2C member 1 [Source:MGI Symbol;Acc:MGI:95755] Location: 4:118965908-118995180 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell epithelial cell Other: Integration of energy metabolism Metabolism of vitamins and cofactors SLC-mediated transmembrane transport Slc40a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000025993 Description: solute carrier family 40 (iron-regulated transporter)%2C member 1 [Source:MGI Symbol;Acc:MGI:1315204] Location: 1:45947228-45965683 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte myeloid cell Other: SLC-mediated transmembrane transport Iron uptake and transport Slc44a2 Gene Information Basic Information Ensembl ID: ENSMUSG00000057193 Description: solute carrier family 44%2C member 2 [Source:MGI Symbol;Acc:MGI:1915932] Location: 9:21231994-21266324 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System SLC-mediated transmembrane transport Metabolism of lipids Slc5a8 Gene Information Basic Information Ensembl ID: ENSMUSG00000020062 Description: solute carrier family 5 (iodide transporter)%2C member 8 [Source:MGI Symbol;Acc:MGI:2384916] Location: 10:88721854-88765377 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Metabolism of vitamins and cofactors SLC-mediated transmembrane transport Slc7a11 Gene Information Basic Information Ensembl ID: ENSMUSG00000027737 Description: solute carrier family 7 (cationic amino acid transporter%2C y+ system)%2C member 11 [Source:MGI Symbol;Acc:MGI:1347355] Location: 3:49846975-50398063 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell fibroblast granulocyte monocyte retinal pigment epithelial cell Other: Cell surface interactions at the vascular wall SLC-mediated transmembrane transport Slco2a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000032548 Description: solute carrier organic anion transporter family%2C member 2a1 [Source:MGI Symbol;Acc:MGI:1346021] Location: 9:102865911-102973201 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: SLC-mediated transmembrane transport Slco3a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000025790 Description: solute carrier organic anion transporter family%2C member 3a1 [Source:MGI Symbol;Acc:MGI:1351867] Location: 7:73925167-74204528 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte hematopoietic stem cell epithelial cell Other: SLC-mediated transmembrane transport
Signaling by Erythropoietin Pathway Hierarchies & Genes Erythropoietin activates RAS (4 genes) Signal Transduction Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 1 genes Erythropoietin activates RAS 3 genes Erythropoietin activates RAS (3 genes) Signal Transduction Signaling by Erythropoietin Erythropoietin activates RAS 3 genes	Crkl Gene Information Basic Information Ensembl ID: ENSMUSG00000006134 Description: v-crk avian sarcoma virus CT10 oncogene homolog-like [Source:MGI Symbol;Acc:MGI:104686] Location: 16:17269851-17305298 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Signaling by Erythropoietin Signaling by Receptor Tyrosine Kinases Gab1 Gene Information Basic Information Ensembl ID: ENSMUSG00000031714 Description: growth factor receptor bound protein 2-associated protein 1 [Source:MGI Symbol;Acc:MGI:108088] Location: 8:81491063-81607148 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte Other: Signaling by Erythropoietin Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Irs2 Gene Information Basic Information Ensembl ID: ENSMUSG00000038894 Description: insulin receptor substrate 2 [Source:MGI Symbol;Acc:MGI:109334] Location: 8:11034681-11058458 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: mural cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades Signaling by Erythropoietin Jak2 Gene Information Basic Information Ensembl ID: ENSMUSG00000024789 Description: Janus kinase 2 [Source:MGI Symbol;Acc:MGI:96629] Location: 19:29229228-29290480 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell dendritic cell eosinophil Other: Cytokine Signaling in Immune system MAPK family signaling cascades Cell Cycle, Mitotic Lyn Gene Information Basic Information Ensembl ID: ENSMUSG00000042228 Description: LYN proto-oncogene%2C Src family tyrosine kinase [Source:MGI Symbol;Acc:MGI:96892] Location: 4:3678115-3813122 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Platelet Adhesion to exposed collagen Cytokine Signaling in Immune system Adaptive Immune System Rapgef1 Gene Information Basic Information Ensembl ID: ENSMUSG00000039844 Description: Rap guanine nucleotide exchange factor (GEF) 1 [Source:MGI Symbol;Acc:MGI:104580] Location: 2:29509732-29630990 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Specialized T cell oligodendrocyte precursor cell Other: Signaling by Erythropoietin Cytokine Signaling in Immune system Signaling by Receptor Tyrosine Kinases Shc1 Gene Information Basic Information Ensembl ID: ENSMUSG00000042626 Description: src homology 2 domain-containing transforming protein C1 [Source:MGI Symbol;Acc:MGI:98296] Location: 3:89325750-89337334 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Innate Immune System Cell surface interactions at the vascular wall
Signaling by GPCR Pathway Hierarchies & Genes Peptide ligand-binding receptors (2 genes) Signal Transduction Signaling by GPCR GPCR downstream signalling G alpha (i) signalling events Opioid Signalling G-protein activation GPCR ligand binding Class A/1 (Rhodopsin-like receptors) Peptide ligand-binding receptors 2 genes phospho-PLA2 pathway (1 genes) Signal Transduction Signaling by GPCR GPCR downstream signalling G alpha (i) signalling events Opioid Signalling G-protein mediated events PLC beta mediated events Ca-dependent events phospho-PLA2 pathway 1 genes Ca-dependent events (1 genes) Signal Transduction Signaling by GPCR GPCR downstream signalling G alpha (i) signalling events Opioid Signalling G-protein mediated events PLC beta mediated events Ca-dependent events 1 genes G alpha (i) signalling events (3 genes) Signal Transduction Signaling by GPCR GPCR ligand binding Class A/1 (Rhodopsin-like receptors) Nucleotide-like (purinergic) receptors Adenosine P1 receptors GPCR downstream signalling G alpha (i) signalling events 3 genes G alpha (i) signalling events (16 genes) Signal Transduction Signaling by GPCR GPCR ligand binding Class A/1 (Rhodopsin-like receptors) Peptide ligand-binding receptors Chemokine receptors bind chemokines 4 genes GPCR downstream signalling G alpha (i) signalling events 12 genes G alpha (q) signalling events (3 genes) Signal Transduction Signaling by GPCR GPCR ligand binding Class A/1 (Rhodopsin-like receptors) Eicosanoid ligand-binding receptors Prostanoid ligand receptors GPCR downstream signalling G alpha (q) signalling events 3 genes G alpha (q) signalling events (2 genes) Signal Transduction Signaling by GPCR GPCR ligand binding Class A/1 (Rhodopsin-like receptors) Peptide ligand-binding receptors Orexin and neuropeptides FF and QRFP bind to their respective receptors GPCR downstream signalling G alpha (q) signalling events 2 genes G alpha (q) signalling events (2 genes) Signal Transduction Signaling by GPCR GPCR ligand binding Class A/1 (Rhodopsin-like receptors) Peptide ligand-binding receptors Vasopressin-like receptors GPCR downstream signalling G alpha (q) signalling events 2 genes G alpha (q) signalling events (2 genes) Signal Transduction Signaling by GPCR GPCR ligand binding Class A/1 (Rhodopsin-like receptors) Peptide ligand-binding receptors Formyl peptide receptors bind formyl peptides and many other ligands GPCR downstream signalling G alpha (q) signalling events 2 genes G alpha (q) signalling events (5 genes) Signal Transduction Signaling by GPCR GPCR ligand binding Class A/1 (Rhodopsin-like receptors) Nucleotide-like (purinergic) receptors P2Y receptors GPCR downstream signalling G alpha (q) signalling events 5 genes G alpha (q) signalling events (1 genes) Signal Transduction Signaling by GPCR GPCR ligand binding Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Muscarinic acetylcholine receptors GPCR downstream signalling G alpha (q) signalling events 1 genes G alpha (s) signalling events (3 genes) Signal Transduction Signaling by GPCR GPCR ligand binding Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Dopamine receptors 1 genes GPCR downstream signalling G alpha (s) signalling events 2 genes G alpha (s) signalling events (7 genes) Signal Transduction Signaling by GPCR GPCR ligand binding Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Adrenoceptors GPCR downstream signalling G alpha (s) signalling events 7 genes G alpha (s) signalling events (1 genes) Signal Transduction Signaling by GPCR GPCR ligand binding Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Histamine receptors GPCR downstream signalling G alpha (s) signalling events 1 genes Gastrin-CREB signalling pathway via PKC and MAPK (11 genes) Signal Transduction Signaling by GPCR GPCR ligand binding Class A/1 (Rhodopsin-like receptors) Peptide ligand-binding receptors GPCR downstream signalling G alpha (q) signalling events 10 genes Gastrin-CREB signalling pathway via PKC and MAPK 1 genes Adenylate cyclase activating pathway (1 genes) Signal Transduction Signaling by GPCR GPCR downstream signalling G alpha (i) signalling events Opioid Signalling G-protein mediated events Adenylate cyclase activating pathway 1 genes Adenylate cyclase inhibitory pathway (2 genes) Signal Transduction Signaling by GPCR GPCR downstream signalling G alpha (i) signalling events Opioid Signalling G-protein mediated events Adenylate cyclase inhibitory pathway 2 genes G alpha (i) signalling events (2 genes) Signal Transduction Signaling by GPCR GPCR ligand binding Class A/1 (Rhodopsin-like receptors) Lysosphingolipid and LPA receptors 1 genes GPCR downstream signalling G alpha (i) signalling events 1 genes G alpha (s) signalling events (3 genes) Signal Transduction Signaling by GPCR GPCR ligand binding Class B/2 (Secretin family receptors) Glucagon-type ligand receptors GPCR downstream signalling G alpha (s) signalling events 3 genes G alpha (s) signalling events (3 genes) Signal Transduction Signaling by GPCR GPCR ligand binding Class B/2 (Secretin family receptors) Calcitonin-like ligand receptors GPCR downstream signalling G alpha (s) signalling events 3 genes G alpha (s) signalling events (1 genes) Signal Transduction Signaling by GPCR GPCR ligand binding Class A/1 (Rhodopsin-like receptors) Hormone ligand-binding receptors GPCR downstream signalling G alpha (s) signalling events 1 genes PLC beta mediated events (3 genes) Signal Transduction Signaling by GPCR GPCR downstream signalling G alpha (i) signalling events Opioid Signalling G-protein mediated events PLC beta mediated events 3 genes Class C/3 (Metabotropic glutamate/pheromone receptors) (3 genes) Signal Transduction Signaling by GPCR GPCR downstream signalling G alpha (i) signalling events 2 genes GPCR ligand binding Class C/3 (Metabotropic glutamate/pheromone receptors) 1 genes Class C/3 (Metabotropic glutamate/pheromone receptors) (1 genes) Signal Transduction Signaling by GPCR GPCR downstream signalling G alpha (q) signalling events GPCR ligand binding Class C/3 (Metabotropic glutamate/pheromone receptors) 1 genes DARPP-32 events (2 genes) Signal Transduction Signaling by GPCR GPCR downstream signalling G alpha (i) signalling events Opioid Signalling DARPP-32 events 2 genes EGFR Transactivation by Gastrin (1 genes) Signal Transduction Signaling by GPCR GPCR downstream signalling G alpha (q) signalling events Gastrin-CREB signalling pathway via PKC and MAPK EGFR Transactivation by Gastrin 1 genes G alpha (q) signalling events (6 genes) Signal Transduction Signaling by GPCR GPCR ligand binding Class A/1 (Rhodopsin-like receptors) 1 genes GPCR downstream signalling G alpha (q) signalling events 5 genes G beta:gamma signalling through BTK (1 genes) Signal Transduction Signaling by GPCR GPCR downstream signalling G-protein beta:gamma signalling G beta:gamma signalling through BTK 1 genes G beta:gamma signalling through CDC42 (2 genes) Signal Transduction Signaling by GPCR GPCR downstream signalling G-protein beta:gamma signalling G beta:gamma signalling through CDC42 2 genes GPER1 signaling (2 genes) Signal Transduction Signaling by GPCR GPCR downstream signalling G alpha (s) signalling events GPER1 signaling 2 genes Gastrin-CREB signalling pathway via PKC and MAPK (1 genes) Signal Transduction Signaling by GPCR GPCR downstream signalling G alpha (q) signalling events Gastrin-CREB signalling pathway via PKC and MAPK 1 genes Class B/2 (Secretin family receptors) (2 genes) Signal Transduction Signaling by GPCR GPCR ligand binding Class B/2 (Secretin family receptors) 2 genes G alpha (12/13) signalling events (4 genes) Signal Transduction Signaling by GPCR GPCR downstream signalling G alpha (12/13) signalling events 4 genes G alpha (s) signalling events (4 genes) Signal Transduction Signaling by GPCR GPCR downstream signalling G alpha (s) signalling events 4 genes G alpha (z) signalling events (1 genes) Signal Transduction Signaling by GPCR GPCR downstream signalling G alpha (z) signalling events 1 genes	Ackr2 Gene Information Basic Information Ensembl ID: ENSMUSG00000044534 Description: atypical chemokine receptor 2 [Source:MGI Symbol;Acc:MGI:1891697] Location: 9:121727421-121740140 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by GPCR Ackr4 Gene Information Basic Information Ensembl ID: ENSMUSG00000079355 Description: atypical chemokine receptor 4 [Source:MGI Symbol;Acc:MGI:2181676] Location: 9:103961356-104004132 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by GPCR Adcyap1 Gene Information Basic Information Ensembl ID: ENSMUSG00000024256 Description: adenylate cyclase activating polypeptide 1 [Source:MGI Symbol;Acc:MGI:105094] Location: 17:93506445-93513965 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by GPCR Adgre1 Gene Information Basic Information Ensembl ID: ENSMUSG00000004730 Description: adhesion G protein-coupled receptor E1 [Source:MGI Symbol;Acc:MGI:106912] Location: 17:57665691-57790527 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte microglia antigen presenting cell T cell macrophage monocyte lymphocyte eosinophil myeloid cell Naive B cell kupffer cell Other: Signaling by GPCR Adgre5 Gene Information Basic Information Ensembl ID: ENSMUSG00000002885 Description: adhesion G protein-coupled receptor E5 [Source:MGI Symbol;Acc:MGI:1347095] Location: 8:84449880-84467955 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell endothelial cell monocyte Other: Innate Immune System Signaling by GPCR Adora1 Gene Information Basic Information Ensembl ID: ENSMUSG00000042429 Description: adenosine A1 receptor [Source:MGI Symbol;Acc:MGI:99401] Location: 1:134126963-134163169 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: excitatory neuron Other: Signaling by GPCR Adora2a Gene Information Basic Information Ensembl ID: ENSMUSG00000020178 Description: adenosine A2a receptor [Source:MGI Symbol;Acc:MGI:99402] Location: 10:75152711-75170618 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by GPCR Surfactant metabolism Adora3 Gene Information Basic Information Ensembl ID: ENSMUSG00000000562 Description: adenosine A3 receptor [Source:MGI Symbol;Acc:MGI:104847] Location: 3:105778174-105816242 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: mast cell Other: Signaling by GPCR Adra1a Gene Information Basic Information Ensembl ID: ENSMUSG00000045875 Description: adrenergic receptor%2C alpha 1a [Source:MGI Symbol;Acc:MGI:104773] Location: 14:66872700-67008617 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: adipocyte interneuron Other: Signaling by GPCR Adra1b Gene Information Basic Information Ensembl ID: ENSMUSG00000050541 Description: adrenergic receptor%2C alpha 1b [Source:MGI Symbol;Acc:MGI:104774] Location: 11:43665433-43792037 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endocrine cell Other: Signaling by GPCR Adra2a Gene Information Basic Information Ensembl ID: ENSMUSG00000033717 Description: adrenergic receptor%2C alpha 2a [Source:MGI Symbol;Acc:MGI:87934] Location: 19:54032582-54037413 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte retina cell mural cell Other: Integration of energy metabolism Signaling by GPCR Surfactant metabolism Adra2c Gene Information Basic Information Ensembl ID: ENSMUSG00000045318 Description: adrenergic receptor%2C alpha 2c [Source:MGI Symbol;Acc:MGI:87936] Location: 5:35435663-35439107 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Integration of energy metabolism Signaling by GPCR Surfactant metabolism Adrb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000035283 Description: adrenergic receptor%2C beta 1 [Source:MGI Symbol;Acc:MGI:87937] Location: 19:56710631-56721545 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: bipolar cell Other: Signaling by GPCR Adrb2 Gene Information Basic Information Ensembl ID: ENSMUSG00000045730 Description: adrenergic receptor%2C beta 2 [Source:MGI Symbol;Acc:MGI:87938] Location: 18:62310887-62313030 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: smooth muscle cell erythroblast Other: Membrane Trafficking Signaling by GPCR Post-translational protein modification Adrb3 Gene Information Basic Information Ensembl ID: ENSMUSG00000031489 Description: adrenergic receptor%2C beta 3 [Source:MGI Symbol;Acc:MGI:87939] Location: 8:27715804-27740644 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: adipocyte Other: Signaling by GPCR Anxa1 Gene Information Basic Information Ensembl ID: ENSMUSG00000024659 Description: annexin A1 [Source:MGI Symbol;Acc:MGI:96819] Location: 19:20350792-20368308 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by GPCR Apln Gene Information Basic Information Ensembl ID: ENSMUSG00000037010 Description: apelin [Source:MGI Symbol;Acc:MGI:1353624] Location: X:47114023-47123730 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Signaling by GPCR Arhgef1 Gene Information Basic Information Ensembl ID: ENSMUSG00000040940 Description: Rho guanine nucleotide exchange factor 1 [Source:MGI Symbol;Acc:MGI:1353510] Location: 7:24602337-24626019 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell CD4+ T cell Specialized T cell CD8+ T cell lymphocyte Other: Signaling by GPCR Death Receptor Signaling Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Arhgef11 Gene Information Basic Information Ensembl ID: ENSMUSG00000041977 Description: Rho guanine nucleotide exchange factor 11 [Source:MGI Symbol;Acc:MGI:2441869] Location: 3:87524866-87645341 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by GPCR Death Receptor Signaling Nervous system development Arhgef2 Gene Information Basic Information Ensembl ID: ENSMUSG00000028059 Description: Rho/Rac guanine nucleotide exchange factor 2 [Source:MGI Symbol;Acc:MGI:103264] Location: 3:88513273-88555359 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Death Receptor Signaling Signaling by GPCR Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Arrb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000018909 Description: arrestin%2C beta 1 [Source:MGI Symbol;Acc:MGI:99473] Location: 7:99184673-99255978 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stromal cell Other: Membrane Trafficking Signaling by GPCR Signaling by Hedgehog Arrb2 Gene Information Basic Information Ensembl ID: ENSMUSG00000060216 Description: arrestin%2C beta 2 [Source:MGI Symbol;Acc:MGI:99474] Location: 11:70323461-70331654 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell antigen presenting cell Other: Signaling by WNT Membrane Trafficking Signaling by GPCR Avpr1a Gene Information Basic Information Ensembl ID: ENSMUSG00000020123 Description: arginine vasopressin receptor 1A [Source:MGI Symbol;Acc:MGI:1859216] Location: 10:122284404-122289357 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by GPCR Avpr1b Gene Information Basic Information Ensembl ID: ENSMUSG00000026432 Description: arginine vasopressin receptor 1B [Source:MGI Symbol;Acc:MGI:1347010] Location: 1:131526977-131539738 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by GPCR Bdkrb2 Gene Information Basic Information Ensembl ID: ENSMUSG00000021070 Description: bradykinin receptor%2C beta 2 [Source:MGI Symbol;Acc:MGI:102845] Location: 12:105529485-105561496 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by GPCR Btk Gene Information Basic Information Ensembl ID: ENSMUSG00000031264 Description: Bruton agammaglobulinemia tyrosine kinase [Source:MGI Symbol;Acc:MGI:88216] Location: X:133443085-133484319 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Naive B cell Other: Adaptive Immune System Innate Immune System Signaling by GPCR Calcr Gene Information Basic Information Ensembl ID: ENSMUSG00000023964 Description: calcitonin receptor [Source:MGI Symbol;Acc:MGI:101950] Location: 6:3685680-3764714 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stem cell intercalated cell Other: Signaling by GPCR Calcrl Gene Information Basic Information Ensembl ID: ENSMUSG00000059588 Description: calcitonin receptor-like [Source:MGI Symbol;Acc:MGI:1926944] Location: 2:84160970-84255755 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell endocardial cell Other: Signaling by GPCR Cellular responses to mechanical stimuli Cckbr Gene Information Basic Information Ensembl ID: ENSMUSG00000030898 Description: cholecystokinin B receptor [Source:MGI Symbol;Acc:MGI:99479] Location: 7:105074938-105120105 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by GPCR Ccl22 Gene Information Basic Information Ensembl ID: ENSMUSG00000031779 Description: C-C motif chemokine ligand 22 [Source:MGI Symbol;Acc:MGI:1306779] Location: 8:95472218-95478327 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell Other: Signaling by GPCR Ccl28 Gene Information Basic Information Ensembl ID: ENSMUSG00000074715 Description: C-C motif chemokine ligand 28 [Source:MGI Symbol;Acc:MGI:1861731] Location: 13:120085355-120115895 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by GPCR Ccr1 Gene Information Basic Information Ensembl ID: ENSMUSG00000025804 Description: C-C motif chemokine receptor 1 [Source:MGI Symbol;Acc:MGI:104618] Location: 9:123762161-123768729 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell dendritic cell phagocyte granulocyte eosinophil leukocyte Other: Signaling by GPCR Ccr3 Gene Information Basic Information Ensembl ID: ENSMUSG00000035448 Description: C-C motif chemokine receptor 3 [Source:MGI Symbol;Acc:MGI:104616] Location: 9:123822009-123831726 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by GPCR Ccr5 Gene Information Basic Information Ensembl ID: ENSMUSG00000079227 Description: C-C motif chemokine receptor 5 [Source:MGI Symbol;Acc:MGI:107182] Location: 9:123921580-123947736 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell phagocyte CD8+ T cell Other: Signaling by GPCR Ccr7 Gene Information Basic Information Ensembl ID: ENSMUSG00000037944 Description: C-C motif chemokine receptor 7 [Source:MGI Symbol;Acc:MGI:103011] Location: 11:99035022-99045903 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell Naive B cell developing T cell Other: Signaling by GPCR Ccr9 Gene Information Basic Information Ensembl ID: ENSMUSG00000029530 Description: C-C motif chemokine receptor 9 [Source:MGI Symbol;Acc:MGI:1341902] Location: 9:123507504-123613395 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell T cell dendritic cell myeloid progenitor cell Other: Signaling by GPCR Ccrl2 Gene Information Basic Information Ensembl ID: ENSMUSG00000043953 Description: C-C motif chemokine receptor-like 2 [Source:MGI Symbol;Acc:MGI:1920904] Location: 9:110883554-110886587 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell pericyte dendritic cell phagocyte mast cell granulocyte Other: Signaling by GPCR Cdc42 Gene Information Basic Information Ensembl ID: ENSMUSG00000006699 Description: cell division cycle 42 [Source:MGI Symbol;Acc:MGI:106211] Location: 4:137047007-137085031 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: hematopoietic stem cell phagocyte antigen presenting cell macrophage dendritic cell Other: Adaptive Immune System Innate Immune System Signaling by GPCR Chrm3 Gene Information Basic Information Ensembl ID: ENSMUSG00000046159 Description: cholinergic receptor%2C muscarinic 3%2C cardiac [Source:MGI Symbol;Acc:MGI:88398] Location: 13:9925522-10410883 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell endocrine cell neuron Other: Signaling by GPCR Cmklr1 Gene Information Basic Information Ensembl ID: ENSMUSG00000042190 Description: chemerin chemokine-like receptor 1 [Source:MGI Symbol;Acc:MGI:109603] Location: 5:113750415-113788487 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by GPCR Cnr1 Gene Information Basic Information Ensembl ID: ENSMUSG00000044288 Description: cannabinoid receptor 1 [Source:MGI Symbol;Acc:MGI:104615] Location: 4:33924593-33948831 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by GPCR Cnr2 Gene Information Basic Information Ensembl ID: ENSMUSG00000062585 Description: cannabinoid receptor 2 [Source:MGI Symbol;Acc:MGI:104650] Location: 4:135622705-135647518 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by GPCR Creb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000025958 Description: cAMP responsive element binding protein 1 [Source:MGI Symbol;Acc:MGI:88494] Location: 1:64571804-64643707 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Transmission across Chemical Synapses Cytokine Signaling in Immune system Innate Immune System Cx3cl1 Gene Information Basic Information Ensembl ID: ENSMUSG00000031778 Description: C-X3-C motif chemokine ligand 1 [Source:MGI Symbol;Acc:MGI:1097153] Location: 8:95498637-95509055 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Signaling by GPCR Cx3cr1 Gene Information Basic Information Ensembl ID: ENSMUSG00000052336 Description: C-X3-C motif chemokine receptor 1 [Source:MGI Symbol;Acc:MGI:1333815] Location: 9:119877749-119898945 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte dendritic cell monocyte antigen presenting cell macrophage erythroblast microglia myeloid cell Other: Signaling by GPCR Cxcl11 Gene Information Basic Information Ensembl ID: ENSMUSG00000060183 Description: chemokine (C-X-C motif) ligand 11 [Source:MGI Symbol;Acc:MGI:1860203] Location: 5:92507403-92513344 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by GPCR Cxcl12 Gene Information Basic Information Ensembl ID: ENSMUSG00000061353 Description: C-X-C motif chemokine ligand 12 [Source:MGI Symbol;Acc:MGI:103556] Location: 6:117145496-117158328 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stellate cell epithelial cell fibroblast stromal cell smooth muscle cell Other: Signaling by GPCR Nervous system development Cxcl16 Gene Information Basic Information Ensembl ID: ENSMUSG00000018920 Description: C-X-C motif chemokine ligand 16 [Source:MGI Symbol;Acc:MGI:1932682] Location: 11:70344809-70350810 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell phagocyte antigen presenting cell monocyte macrophage leukocyte Other: Signaling by GPCR Cxcl9 Gene Information Basic Information Ensembl ID: ENSMUSG00000029417 Description: C-X-C motif chemokine ligand 9 [Source:MGI Symbol;Acc:MGI:1352449] Location: 5:92469206-92475938 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Signaling by GPCR Cxcr5 Gene Information Basic Information Ensembl ID: ENSMUSG00000047880 Description: C-X-C motif chemokine receptor 5 [Source:MGI Symbol;Acc:MGI:103567] Location: 9:44423084-44473174 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Naive B cell T helper cell Other: Signaling by GPCR Drd1 Gene Information Basic Information Ensembl ID: ENSMUSG00000021478 Description: dopamine receptor D1 [Source:MGI Symbol;Acc:MGI:99578] Location: 13:54205202-54209724 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by GPCR Drd2 Gene Information Basic Information Ensembl ID: ENSMUSG00000032259 Description: dopamine receptor D2 [Source:MGI Symbol;Acc:MGI:94924] Location: 9:49251927-49319477 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: retina cell projection neuron Other: Signaling by GPCR Drd4 Gene Information Basic Information Ensembl ID: ENSMUSG00000025496 Description: dopamine receptor D4 [Source:MGI Symbol;Acc:MGI:94926] Location: 7:140871919-140876377 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: photoreceptor cell Other: Signaling by GPCR Ednra Gene Information Basic Information Ensembl ID: ENSMUSG00000031616 Description: endothelin receptor type A [Source:MGI Symbol;Acc:MGI:105923] Location: 8:78389660-78451093 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte stellate cell mast cell mural cell Other: Signaling by GPCR Ednrb Gene Information Basic Information Ensembl ID: ENSMUSG00000022122 Description: endothelin receptor type B [Source:MGI Symbol;Acc:MGI:102720] Location: 14:104052061-104081838 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell endothelial cell glial cell oligodendrocyte precursor cell mural cell macrophage epithelial cell melanocyte pneumocyte capillary cell Other: Signaling by GPCR F2r Gene Information Basic Information Ensembl ID: ENSMUSG00000048376 Description: coagulation factor II thrombin receptor [Source:MGI Symbol;Acc:MGI:101802] Location: 13:95738311-95754995 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell fibroblast cardiomyocyte endocardial cell megakaryocyte Other: Formation of Fibrin Clot (Clotting Cascade) Signaling by GPCR Platelet activation, signaling and aggregation F2rl1 Gene Information Basic Information Ensembl ID: ENSMUSG00000021678 Description: F2R like trypsin receptor 1 [Source:MGI Symbol;Acc:MGI:101910] Location: 13:95648240-95661735 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by GPCR Fpr1 Gene Information Basic Information Ensembl ID: ENSMUSG00000045551 Description: formyl peptide receptor 1 [Source:MGI Symbol;Acc:MGI:107443] Location: 17:18096733-18104202 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell mast cell neutrophil Other: Innate Immune System Signaling by GPCR Gabbr1 Gene Information Basic Information Ensembl ID: ENSMUSG00000024462 Description: gamma-aminobutyric acid type B receptor subunit 1 [Source:MGI Symbol;Acc:MGI:1860139] Location: 17:37356858-37385959 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Transmission across Chemical Synapses Potassium Channels Signaling by GPCR Gna11 Gene Information Basic Information Ensembl ID: ENSMUSG00000034781 Description: guanine nucleotide binding protein%2C alpha 11 [Source:MGI Symbol;Acc:MGI:95766] Location: 10:81364558-81381024 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell endothelial cell enterocyte Other: Integration of energy metabolism Signaling by GPCR Protein folding Gna13 Gene Information Basic Information Ensembl ID: ENSMUSG00000020611 Description: guanine nucleotide binding protein%2C alpha 13 [Source:MGI Symbol;Acc:MGI:95768] Location: 11:109253657-109292195 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell developing T cell innate lymphoid cell Other: Signaling by GPCR Death Receptor Signaling Platelet activation, signaling and aggregation Gna14 Gene Information Basic Information Ensembl ID: ENSMUSG00000024697 Description: guanine nucleotide binding protein%2C alpha 14 [Source:MGI Symbol;Acc:MGI:95769] Location: 19:16413126-16588184 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell epithelial cell Other: Integration of energy metabolism Signaling by GPCR Protein folding Gnai1 Gene Information Basic Information Ensembl ID: ENSMUSG00000057614 Description: G protein subunit alpha i1 [Source:MGI Symbol;Acc:MGI:95771] Location: 5:18470133-18565353 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: mast cell adipocyte Other: Transmission across Chemical Synapses Integration of energy metabolism Signaling by GPCR Gnai3 Gene Information Basic Information Ensembl ID: ENSMUSG00000000001 Description: G protein subunit alpha i3 [Source:MGI Symbol;Acc:MGI:95773] Location: 3:108014596-108053462 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Transmission across Chemical Synapses Signaling by GPCR Platelet activation, signaling and aggregation Gnal Gene Information Basic Information Ensembl ID: ENSMUSG00000024524 Description: guanine nucleotide binding protein%2C alpha stimulating%2C olfactory type [Source:MGI Symbol;Acc:MGI:95774] Location: 18:67221287-67359863 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: projection neuron Other: Transmission across Chemical Synapses Signaling by GPCR Olfactory Signaling Pathway Gnaq Gene Information Basic Information Ensembl ID: ENSMUSG00000024639 Description: guanine nucleotide binding protein%2C alpha q polypeptide [Source:MGI Symbol;Acc:MGI:95776] Location: 19:16110195-16364827 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: antigen presenting cell Other: Integration of energy metabolism Signaling by GPCR Protein folding Gnat1 Gene Information Basic Information Ensembl ID: ENSMUSG00000034837 Description: G protein subunit alpha transducin 1 [Source:MGI Symbol;Acc:MGI:95778] Location: 9:107551673-107556911 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: photoreceptor cell Other: Visual phototransduction Signaling by GPCR Gnaz Gene Information Basic Information Ensembl ID: ENSMUSG00000040009 Description: guanine nucleotide binding protein%2C alpha z subunit [Source:MGI Symbol;Acc:MGI:95780] Location: 10:74803009-74852739 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: megakaryocyte Other: Signaling by GPCR Gngt2 Gene Information Basic Information Ensembl ID: ENSMUSG00000038811 Description: guanine nucleotide binding protein (G protein)%2C gamma transducing activity polypeptide 2 [Source:MGI Symbol;Acc:MGI:893584] Location: 11:95728042-95736560 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell dendritic cell phagocyte monocyte myeloid cell plasma cell macrophage photoreceptor cell Other: Platelet homeostasis Transmission across Chemical Synapses Potassium Channels Gpr65 Gene Information Basic Information Ensembl ID: ENSMUSG00000021886 Description: G-protein coupled receptor 65 [Source:MGI Symbol;Acc:MGI:108031] Location: 12:98234894-98242903 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: mast cell macrophage Other: Signaling by GPCR Grk2 Gene Information Basic Information Ensembl ID: ENSMUSG00000024858 Description: G protein-coupled receptor kinase 2 [Source:MGI Symbol;Acc:MGI:87940] Location: 19:4336029-4356250 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Membrane Trafficking Signaling by GPCR Signaling by Hedgehog Grk3 Gene Information Basic Information Ensembl ID: ENSMUSG00000042249 Description: G protein-coupled receptor kinase 3 [Source:MGI Symbol;Acc:MGI:87941] Location: 5:113058348-113163657 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: bone cell monocyte dendritic cell Other: Membrane Trafficking Signaling by GPCR Grm5 Gene Information Basic Information Ensembl ID: ENSMUSG00000049583 Description: glutamate receptor%2C metabotropic 5 [Source:MGI Symbol;Acc:MGI:1351342] Location: 7:87233376-87784115 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Signaling by GPCR Protein-protein interactions at synapses Hc Gene Information Basic Information Ensembl ID: ENSMUSG00000026874 Description: hemolytic complement [Source:MGI Symbol;Acc:MGI:96031] Location: 2:34873343-34951450 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pneumocyte Other: Innate Immune System Signaling by GPCR Hrh2 Gene Information Basic Information Ensembl ID: ENSMUSG00000034987 Description: histamine receptor H2 [Source:MGI Symbol;Acc:MGI:108482] Location: 13:54346148-54390199 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by GPCR Itga5 Gene Information Basic Information Ensembl ID: ENSMUSG00000000555 Description: integrin alpha 5 (fibronectin receptor alpha) [Source:MGI Symbol;Acc:MGI:96604] Location: 15:103252713-103275190 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Elastic fibre formation Fibronectin matrix formation Cell surface interactions at the vascular wall Kiss1r Gene Information Basic Information Ensembl ID: ENSMUSG00000035773 Description: KISS1 receptor [Source:MGI Symbol;Acc:MGI:2148793] Location: 10:79752805-79758107 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by GPCR Lhcgr Gene Information Basic Information Ensembl ID: ENSMUSG00000024107 Description: luteinizing hormone/choriogonadotropin receptor [Source:MGI Symbol;Acc:MGI:96783] Location: 17:89023909-89099418 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stromal cell leydig cell Other: Signaling by GPCR Lpar6 Gene Information Basic Information Ensembl ID: ENSMUSG00000033446 Description: lysophosphatidic acid receptor 6 [Source:MGI Symbol;Acc:MGI:1914418] Location: 14:73475335-73480734 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell Specialized T cell Other: Signaling by GPCR Mtnr1a Gene Information Basic Information Ensembl ID: ENSMUSG00000054764 Description: melatonin receptor 1A [Source:MGI Symbol;Acc:MGI:102967] Location: 8:45522174-45541543 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by GPCR Npffr1 Gene Information Basic Information Ensembl ID: ENSMUSG00000020090 Description: neuropeptide FF receptor 1 [Source:MGI Symbol;Acc:MGI:2685082] Location: 10:61431271-61464344 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Signaling by GPCR Npy1r Gene Information Basic Information Ensembl ID: ENSMUSG00000036437 Description: neuropeptide Y receptor Y1 [Source:MGI Symbol;Acc:MGI:104963] Location: 8:67149844-67159444 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: smooth muscle cell mural cell Other: Signaling by GPCR Ntsr1 Gene Information Basic Information Ensembl ID: ENSMUSG00000027568 Description: neurotensin receptor 1 [Source:MGI Symbol;Acc:MGI:97386] Location: 2:180141769-180186773 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by GPCR P2ry1 Gene Information Basic Information Ensembl ID: ENSMUSG00000027765 Description: purinergic receptor P2Y%2C G-protein coupled 1 [Source:MGI Symbol;Acc:MGI:105049] Location: 3:60910216-60916403 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by GPCR Platelet activation, signaling and aggregation P2ry14 Gene Information Basic Information Ensembl ID: ENSMUSG00000036381 Description: purinergic receptor P2Y%2C G-protein coupled%2C 14 [Source:MGI Symbol;Acc:MGI:2155705] Location: 3:59021276-59061039 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell pericyte smooth muscle cell fibroblast mast cell dendritic cell myeloid progenitor cell Other: Signaling by GPCR P2ry2 Gene Information Basic Information Ensembl ID: ENSMUSG00000032860 Description: purinergic receptor P2Y%2C G-protein coupled 2 [Source:MGI Symbol;Acc:MGI:105107] Location: 7:100645775-100662073 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by GPCR Surfactant metabolism Cellular responses to mechanical stimuli P2ry6 Gene Information Basic Information Ensembl ID: ENSMUSG00000048779 Description: pyrimidinergic receptor P2Y%2C G-protein coupled%2C 6 [Source:MGI Symbol;Acc:MGI:2673874] Location: 7:100586837-100623856 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte microglia monocyte macrophage dendritic cell Other: Signaling by GPCR Pak1 Gene Information Basic Information Ensembl ID: ENSMUSG00000030774 Description: p21 (RAC1) activated kinase 1 [Source:MGI Symbol;Acc:MGI:1339975] Location: 7:97437748-97561588 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell epithelial cell excitatory neuron Other: Adaptive Immune System Innate Immune System Signaling by GPCR Pde10a Gene Information Basic Information Ensembl ID: ENSMUSG00000023868 Description: phosphodiesterase 10A [Source:MGI Symbol;Acc:MGI:1345143] Location: 17:8744204-9205480 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron stem cell epithelial cell Other: Signaling by GPCR Platelet homeostasis Pde4d Gene Information Basic Information Ensembl ID: ENSMUSG00000021699 Description: phosphodiesterase 4D%2C cAMP specific [Source:MGI Symbol;Acc:MGI:99555] Location: 13:108586482-110089995 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell skeletal muscle cell neuron pneumocyte stromal cell Other: Signaling by GPCR Cellular responses to mechanical stimuli Pdyn Gene Information Basic Information Ensembl ID: ENSMUSG00000027400 Description: prodynorphin [Source:MGI Symbol;Acc:MGI:97535] Location: 2:129528485-129541764 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by GPCR Pla2g4a Gene Information Basic Information Ensembl ID: ENSMUSG00000056220 Description: phospholipase A2%2C group IVA (cytosolic%2C calcium-dependent) [Source:MGI Symbol;Acc:MGI:1195256] Location: 1:149705369-149837041 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Membrane Trafficking Signaling by GPCR Platelet homeostasis Ppp2ca Gene Information Basic Information Ensembl ID: ENSMUSG00000020349 Description: protein phosphatase 2 (formerly 2A)%2C catalytic subunit%2C alpha isoform [Source:MGI Symbol;Acc:MGI:1321159] Location: 11:51989508-52018605 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Ptafr Gene Information Basic Information Ensembl ID: ENSMUSG00000056529 Description: platelet-activating factor receptor [Source:MGI Symbol;Acc:MGI:106066] Location: 4:132291378-132309994 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell granulocyte T cell Other: Innate Immune System Signaling by GPCR Ptgdr Gene Information Basic Information Ensembl ID: ENSMUSG00000071489 Description: prostaglandin D receptor [Source:MGI Symbol;Acc:MGI:102966] Location: 14:45088692-45096832 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Signaling by GPCR Ptger1 Gene Information Basic Information Ensembl ID: ENSMUSG00000019464 Description: prostaglandin E receptor 1 (subtype EP1) [Source:MGI Symbol;Acc:MGI:97793] Location: 8:84393307-84399382 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by GPCR Ptger4 Gene Information Basic Information Ensembl ID: ENSMUSG00000039942 Description: prostaglandin E receptor 4 (subtype EP4) [Source:MGI Symbol;Acc:MGI:104311] Location: 15:5236142-5273668 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by GPCR Qrfp Gene Information Basic Information Ensembl ID: ENSMUSG00000043102 Description: pyroglutamylated RFamide peptide [Source:MGI Symbol;Acc:MGI:3630329] Location: 2:31696178-31700592 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by GPCR Ramp1 Gene Information Basic Information Ensembl ID: ENSMUSG00000034353 Description: receptor (calcitonin) activity modifying protein 1 [Source:MGI Symbol;Acc:MGI:1858418] Location: 1:91107544-91152918 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell T cell stellate cell stem cell hematopoietic stem cell CD4+ T cell epithelial cell Specialized T cell smooth muscle cell goblet cell dendritic cell mural cell innate lymphoid cell myeloid progenitor cell Other: Signaling by GPCR S1pr1 Gene Information Basic Information Ensembl ID: ENSMUSG00000045092 Description: sphingosine-1-phosphate receptor 1 [Source:MGI Symbol;Acc:MGI:1096355] Location: 3:115504082-115508721 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell developing T cell Other: Signaling by GPCR S1pr2 Gene Information Basic Information Ensembl ID: ENSMUSG00000043895 Description: sphingosine-1-phosphate receptor 2 [Source:MGI Symbol;Acc:MGI:99569] Location: 9:20873657-20888077 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by GPCR Shc1 Gene Information Basic Information Ensembl ID: ENSMUSG00000042626 Description: src homology 2 domain-containing transforming protein C1 [Source:MGI Symbol;Acc:MGI:98296] Location: 3:89325750-89337334 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Innate Immune System Cell surface interactions at the vascular wall Sos1 Gene Information Basic Information Ensembl ID: ENSMUSG00000024241 Description: SOS Ras/Rac guanine nucleotide exchange factor 1 [Source:MGI Symbol;Acc:MGI:98354] Location: 17:80701180-80787882 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Vipr1 Gene Information Basic Information Ensembl ID: ENSMUSG00000032528 Description: vasoactive intestinal peptide receptor 1 [Source:MGI Symbol;Acc:MGI:109272] Location: 9:121471782-121502020 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell Other: Signaling by GPCR Vipr2 Gene Information Basic Information Ensembl ID: ENSMUSG00000011171 Description: vasoactive intestinal peptide receptor 2 [Source:MGI Symbol;Acc:MGI:107166] Location: 12:116041346-116109881 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron photoreceptor cell Other: Signaling by GPCR
Signaling by Hedgehog Pathway Hierarchies & Genes Ligand-receptor interactions (1 genes) Signal Transduction Signaling by Hedgehog Hedgehog ligand biogenesis Release of Hh-Np from the secreting cell Hedgehog 'on' state Ligand-receptor interactions 1 genes Activation of SMO (5 genes) Signal Transduction Signaling by Hedgehog Hedgehog 'off' state 3 genes Hedgehog 'on' state Activation of SMO 2 genes Activation of SMO (3 genes) Signal Transduction Signaling by Hedgehog Hedgehog 'on' state Activation of SMO 3 genes GLI3 is processed to GLI3R by the proteasome (1 genes) Signal Transduction Signaling by Hedgehog Hedgehog 'off' state GLI3 is processed to GLI3R by the proteasome 1 genes Ligand-receptor interactions (2 genes) Signal Transduction Signaling by Hedgehog Hedgehog 'on' state Ligand-receptor interactions 2 genes Hedgehog 'on' state (2 genes) Signal Transduction Signaling by Hedgehog Hedgehog 'on' state 2 genes	Arrb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000018909 Description: arrestin%2C beta 1 [Source:MGI Symbol;Acc:MGI:99473] Location: 7:99184673-99255978 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stromal cell Other: Membrane Trafficking Signaling by GPCR Signaling by Hedgehog Arrb2 Gene Information Basic Information Ensembl ID: ENSMUSG00000060216 Description: arrestin%2C beta 2 [Source:MGI Symbol;Acc:MGI:99474] Location: 11:70323461-70331654 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell antigen presenting cell Other: Signaling by WNT Membrane Trafficking Signaling by GPCR Cdon Gene Information Basic Information Ensembl ID: ENSMUSG00000038119 Description: cell adhesion molecule-related/down-regulated by oncogenes [Source:MGI Symbol;Acc:MGI:1926387] Location: 9:35332424-35418948 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stem cell epithelial cell glial cell Other: Myogenesis Signaling by Hedgehog Fuz Gene Information Basic Information Ensembl ID: ENSMUSG00000011658 Description: fuzzy planar cell polarity protein [Source:MGI Symbol;Acc:MGI:1917550] Location: 7:44545503-44552055 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by Hedgehog Grk2 Gene Information Basic Information Ensembl ID: ENSMUSG00000024858 Description: G protein-coupled receptor kinase 2 [Source:MGI Symbol;Acc:MGI:87940] Location: 19:4336029-4356250 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Membrane Trafficking Signaling by GPCR Signaling by Hedgehog Gsk3b Gene Information Basic Information Ensembl ID: ENSMUSG00000022812 Description: glycogen synthase kinase 3 beta [Source:MGI Symbol;Acc:MGI:1861437] Location: 16:37909363-38066446 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by WNT Epigenetic regulation of gene expression Cellular responses to stress Hhip Gene Information Basic Information Ensembl ID: ENSMUSG00000064325 Description: Hedgehog-interacting protein [Source:MGI Symbol;Acc:MGI:1341847] Location: 8:80692480-80784635 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell fibroblast smooth muscle cell Other: Signaling by Hedgehog Ptch1 Gene Information Basic Information Ensembl ID: ENSMUSG00000021466 Description: patched 1 [Source:MGI Symbol;Acc:MGI:105373] Location: 13:63656142-63721412 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: bergmann glial cell glial cell osteoblast astrocyte fibroblast Other: Signaling by Hedgehog Rpgrip1l Gene Information Basic Information Ensembl ID: ENSMUSG00000033282 Description: Rpgrip1-like [Source:MGI Symbol;Acc:MGI:1920563] Location: 8:91943658-92039890 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cilium Assembly Signaling by Hedgehog Shh Gene Information Basic Information Ensembl ID: ENSMUSG00000002633 Description: sonic hedgehog [Source:MGI Symbol;Acc:MGI:98297] Location: 5:28661813-28672254 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by Hedgehog Smo Gene Information Basic Information Ensembl ID: ENSMUSG00000001761 Description: smoothened%2C frizzled class receptor [Source:MGI Symbol;Acc:MGI:108075] Location: 6:29735502-29761364 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by Hedgehog Cilium Assembly Smurf1 Gene Information Basic Information Ensembl ID: ENSMUSG00000038780 Description: SMAD specific E3 ubiquitin protein ligase 1 [Source:MGI Symbol;Acc:MGI:1923038] Location: 5:144813305-144902657 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Adaptive Immune System Signaling by WNT Signaling by Hedgehog Smurf2 Gene Information Basic Information Ensembl ID: ENSMUSG00000018363 Description: SMAD specific E3 ubiquitin protein ligase 2 [Source:MGI Symbol;Acc:MGI:1913563] Location: 11:106710892-106811541 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Adaptive Immune System Signaling by WNT Signaling by Hedgehog Tulp3 Gene Information Basic Information Ensembl ID: ENSMUSG00000001521 Description: TUB like protein 3 [Source:MGI Symbol;Acc:MGI:1329045] Location: 6:128298124-128332814 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: astrocyte Other: Signaling by Hedgehog
Signaling by Hippo Pathway Hierarchies & Genes Signaling by Hippo (5 genes) Signal Transduction Signaling by Hippo 5 genes	Amotl1 Gene Information Basic Information Ensembl ID: ENSMUSG00000013076 Description: angiomotin-like 1 [Source:MGI Symbol;Acc:MGI:1922973] Location: 9:14453262-14556352 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: skeletal muscle cell Other: Signaling by Hippo Casp3 Gene Information Basic Information Ensembl ID: ENSMUSG00000031628 Description: caspase 3 [Source:MGI Symbol;Acc:MGI:107739] Location: 8:47070326-47092724 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell eosinophil Other: Apoptosis Cytokine Signaling in Immune system Signaling by Hippo Dvl2 Gene Information Basic Information Ensembl ID: ENSMUSG00000020888 Description: dishevelled segment polarity protein 2 [Source:MGI Symbol;Acc:MGI:106613] Location: 11:69891421-69903127 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by Hippo Membrane Trafficking Signaling by WNT Tjp1 Gene Information Basic Information Ensembl ID: ENSMUSG00000030516 Description: tight junction protein 1 [Source:MGI Symbol;Acc:MGI:98759] Location: 7:64945913-65177529 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell epithelial cell Other: Apoptosis Membrane Trafficking Signaling by Hippo Tjp2 Gene Information Basic Information Ensembl ID: ENSMUSG00000024812 Description: tight junction protein 2 [Source:MGI Symbol;Acc:MGI:1341872] Location: 19:24071869-24202394 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron epithelial cell Other: Apoptosis Signaling by Hippo Signaling by Rho GTPases, Miro GTPases and RHOBTB3
Signaling by NODAL Pathway Hierarchies & Genes Signaling by NODAL (2 genes) Developmental Biology Signaling by NODAL 2 genes	Smad2 Gene Information Basic Information Ensembl ID: ENSMUSG00000024563 Description: SMAD family member 2 [Source:MGI Symbol;Acc:MGI:108051] Location: 18:76374651-76444034 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Post-translational protein modification Signaling by NODAL RNA Polymerase II Transcription Smad3 Gene Information Basic Information Ensembl ID: ENSMUSG00000032402 Description: SMAD family member 3 [Source:MGI Symbol;Acc:MGI:1201674] Location: 9:63554049-63665276 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Specialized T cell Other: Signaling by NODAL Post-translational protein modification RNA Polymerase II Transcription
Signaling by NOTCH Pathway Hierarchies & Genes NOTCH1 Intracellular Domain Regulates Transcription (1 genes) Signal Transduction Signaling by NOTCH Pre-NOTCH Expression and Processing Pre-NOTCH Processing in Golgi Signaling by NOTCH1 NOTCH1 Intracellular Domain Regulates Transcription 1 genes Noncanonical activation of NOTCH3 (1 genes) Signal Transduction Signaling by NOTCH Signaling by NOTCH3 NOTCH3 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 1 genes NOTCH1 Intracellular Domain Regulates Transcription (1 genes) Signal Transduction Signaling by NOTCH Signaling by NOTCH1 NOTCH1 Intracellular Domain Regulates Transcription 1 genes	Notch1 Gene Information Basic Information Ensembl ID: ENSMUSG00000026923 Description: notch 1 [Source:MGI Symbol;Acc:MGI:97363] Location: 2:26347915-26406675 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell neuron CD4+ T cell epithelial cell smooth muscle cell T cell Other: Signaling by NOTCH RNA Polymerase II Transcription Psen1 Gene Information Basic Information Ensembl ID: ENSMUSG00000019969 Description: presenilin 1 [Source:MGI Symbol;Acc:MGI:1202717] Location: 12:83734926-83781973 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Signaling by NOTCH Death Receptor Signaling Rbpj Gene Information Basic Information Ensembl ID: ENSMUSG00000039191 Description: recombination signal binding protein for immunoglobulin kappa J region [Source:MGI Symbol;Acc:MGI:96522] Location: 5:53623494-53814704 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron phagocyte dendritic cell antigen presenting cell Other: Signaling by NOTCH RNA Polymerase II Transcription
Signaling by Non-Receptor Tyrosine Kinases Pathway Hierarchies & Genes PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (1 genes) Signal Transduction Signaling by Non-Receptor Tyrosine Kinases Signaling by PTK6 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 1 genes PTK6 promotes HIF1A stabilization (1 genes) Signal Transduction Signaling by Non-Receptor Tyrosine Kinases Signaling by PTK6 PTK6 promotes HIF1A stabilization 1 genes	Bcar1 Gene Information Basic Information Ensembl ID: ENSMUSG00000031955 Description: breast cancer anti-estrogen resistance 1 [Source:MGI Symbol;Acc:MGI:108091] Location: 8:112437106-112470441 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Integrin signaling Platelet activation, signaling and aggregation Signaling by Non-Receptor Tyrosine Kinases Gpnmb Gene Information Basic Information Ensembl ID: ENSMUSG00000029816 Description: glycoprotein (transmembrane) nmb [Source:MGI Symbol;Acc:MGI:1934765] Location: 6:49013480-49047863 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte epithelial cell melanocyte Other: Signaling by Non-Receptor Tyrosine Kinases
Signaling by Nuclear Receptors Pathway Hierarchies & Genes Estrogen-dependent nuclear events downstream of ESR-membrane signaling (1 genes) Signal Transduction Signaling by Nuclear Receptors ESR-mediated signaling Extra-nuclear estrogen signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling 1 genes Estrogen-dependent gene expression (3 genes) Signal Transduction Signaling by Nuclear Receptors ESR-mediated signaling Estrogen-dependent gene expression 3 genes Extra-nuclear estrogen signaling (8 genes) Signal Transduction Signaling by Nuclear Receptors ESR-mediated signaling Extra-nuclear estrogen signaling 8 genes RA biosynthesis pathway (2 genes) Signal Transduction Signaling by Nuclear Receptors Signaling by Retinoic Acid RA biosynthesis pathway 2 genes Signaling by Retinoic Acid (1 genes) Signal Transduction Signaling by Nuclear Receptors Signaling by Retinoic Acid 1 genes	Cav1 Gene Information Basic Information Ensembl ID: ENSMUSG00000007655 Description: caveolin 1%2C caveolae protein [Source:MGI Symbol;Acc:MGI:102709] Location: 6:17306334-17341451 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by WNT Metabolism of nitric oxide: NOS3 activation and regulation Cell surface interactions at the vascular wall Cav2 Gene Information Basic Information Ensembl ID: ENSMUSG00000000058 Description: caveolin 2 [Source:MGI Symbol;Acc:MGI:107571] Location: 6:17281184-17289114 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Signaling by Nuclear Receptors Creb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000025958 Description: cAMP responsive element binding protein 1 [Source:MGI Symbol;Acc:MGI:88494] Location: 1:64571804-64643707 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Transmission across Chemical Synapses Cytokine Signaling in Immune system Innate Immune System Cyp26a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000024987 Description: cytochrome P450%2C family 26%2C subfamily a%2C polypeptide 1 [Source:MGI Symbol;Acc:MGI:1096359] Location: 19:37686246-37689984 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Biological oxidations Signaling by Nuclear Receptors Esr1 Gene Information Basic Information Ensembl ID: ENSMUSG00000019768 Description: estrogen receptor 1 (alpha) [Source:MGI Symbol;Acc:MGI:1352467] Location: 10:4561593-4955614 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by Receptor Tyrosine Kinases Cellular responses to stress Post-translational protein modification Foxa1 Gene Information Basic Information Ensembl ID: ENSMUSG00000035451 Description: forkhead box A1 [Source:MGI Symbol;Acc:MGI:1347472] Location: 12:57587414-57593702 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Signaling by Nuclear Receptors Gata3 Gene Information Basic Information Ensembl ID: ENSMUSG00000015619 Description: GATA binding protein 3 [Source:MGI Symbol;Acc:MGI:95663] Location: 2:9861889-9894845 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Regulatory T cell epithelial cell stem cell CD4+ T cell innate lymphoid cell developing T cell mesangial cell Other: Post-translational protein modification RNA Polymerase II Transcription Signaling by Nuclear Receptors Gnai1 Gene Information Basic Information Ensembl ID: ENSMUSG00000057614 Description: G protein subunit alpha i1 [Source:MGI Symbol;Acc:MGI:95771] Location: 5:18470133-18565353 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: mast cell adipocyte Other: Transmission across Chemical Synapses Integration of energy metabolism Signaling by GPCR Gnai3 Gene Information Basic Information Ensembl ID: ENSMUSG00000000001 Description: G protein subunit alpha i3 [Source:MGI Symbol;Acc:MGI:95773] Location: 3:108014596-108053462 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Transmission across Chemical Synapses Signaling by GPCR Platelet activation, signaling and aggregation Gngt2 Gene Information Basic Information Ensembl ID: ENSMUSG00000038811 Description: guanine nucleotide binding protein (G protein)%2C gamma transducing activity polypeptide 2 [Source:MGI Symbol;Acc:MGI:893584] Location: 11:95728042-95736560 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell dendritic cell phagocyte monocyte myeloid cell plasma cell macrophage photoreceptor cell Other: Platelet homeostasis Transmission across Chemical Synapses Potassium Channels Med1 Gene Information Basic Information Ensembl ID: ENSMUSG00000018160 Description: mediator complex subunit 1 [Source:MGI Symbol;Acc:MGI:1100846] Location: 11:98042980-98084119 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cellular responses to stress Metabolism of lipids RNA Polymerase II Transcription Mmp2 Gene Information Basic Information Ensembl ID: ENSMUSG00000031740 Description: matrix metallopeptidase 2 [Source:MGI Symbol;Acc:MGI:97009] Location: 8:93553919-93580048 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Degradation of the extracellular matrix Signaling by Nuclear Receptors Nervous system development Ppard Gene Information Basic Information Ensembl ID: ENSMUSG00000002250 Description: peroxisome proliferator activator receptor delta [Source:MGI Symbol;Acc:MGI:101884] Location: 17:28451674-28520448 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Metabolism of lipids RNA Polymerase II Transcription Signaling by Nuclear Receptors Rdh10 Gene Information Basic Information Ensembl ID: ENSMUSG00000025921 Description: retinol dehydrogenase 10 (all-trans) [Source:MGI Symbol;Acc:MGI:1924238] Location: 1:16175998-16203958 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell epithelial cell retinal pigment epithelial cell Other: Visual phototransduction Signaling by Nuclear Receptors Shc1 Gene Information Basic Information Ensembl ID: ENSMUSG00000042626 Description: src homology 2 domain-containing transforming protein C1 [Source:MGI Symbol;Acc:MGI:98296] Location: 3:89325750-89337334 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Innate Immune System Cell surface interactions at the vascular wall
Signaling by Receptor Tyrosine Kinases Pathway Hierarchies & Genes Signaling by LTK (1 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by Insulin receptor Insulin receptor signalling cascade IRS-mediated signalling SOS-mediated signalling Signaling by ERBB2 GRB2 events in ERBB2 signaling Signaling by ERBB4 SHC1 events in ERBB4 signaling Signaling by SCF-KIT Regulation of KIT signaling Signaling by NTRKs Signaling by NTRK1 (TRKA) Signalling to ERKs Signalling to RAS Signaling by EGFR GRB2 events in EGFR signaling Signaling by PDGF Downstream signal transduction Signaling by FGFR Signaling by FGFR1 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IGF1R signaling cascade IRS-related events triggered by IGF1R Signaling by MET MET activates RAS signaling Signaling by LTK 1 genes Signaling by LTK (1 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by ERBB2 SHC1 events in ERBB2 signaling Signaling by ERBB4 SHC1 events in ERBB4 signaling Signaling by NTRKs Signaling by NTRK1 (TRKA) Signalling to ERKs Signalling to RAS Signaling by EGFR SHC1 events in EGFR signaling Signaling by FGFR Signaling by FGFR1 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 Signaling by ALK Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IGF1R signaling cascade SHC-related events triggered by IGF1R Signaling by MET MET activates RAS signaling Signaling by Insulin receptor Insulin receptor signalling cascade Signal attenuation Signaling by LTK 1 genes MET activates RAP1 and RAC1 (11 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by Insulin receptor Insulin receptor signalling cascade IRS-mediated signalling PI3K Cascade Signaling by ERBB2 PI3K events in ERBB2 signaling Signaling by EGFR 1 genes GAB1 signalosome Signaling by FGFR Signaling by FGFR1 1 genes Downstream signaling of activated FGFR1 6 genes PI-3K cascade:FGFR1 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IGF1R signaling cascade IRS-related events triggered by IGF1R Signaling by MET 1 genes MET promotes cell motility MET activates RAP1 and RAC1 2 genes Signaling by ALK (2 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by NTRKs Signaling by NTRK2 (TRKB) Activated NTRK2 signals through PLCG1 Signaling by EGFR 1 genes EGFR interacts with phospholipase C-gamma Signaling by PDGF Downstream signal transduction Signaling by FGFR Signaling by FGFR1 Downstream signaling of activated FGFR1 Phospholipase C-mediated cascade: FGFR1 Signaling by VEGF VEGFA-VEGFR2 Pathway VEGFR2 mediated cell proliferation Signaling by ALK 1 genes MET activates RAP1 and RAC1 (3 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by NTRKs Signaling by NTRK1 (TRKA) Signalling to ERKs Prolonged ERK activation events Frs2-mediated activation 1 genes Signaling by PDGF Downstream signal transduction Signaling by MET MET promotes cell motility MET activates RAP1 and RAC1 2 genes ERKs are inactivated (1 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by FGFR Signaling by FGFR1 Negative regulation of FGFR1 signaling Spry regulation of FGF signaling Signaling by NTRKs Signaling by NTRK1 (TRKA) Nuclear Events (kinase and transcription factor activation) ERK/MAPK targets ERKs are inactivated 1 genes VEGFA-VEGFR2 Pathway (5 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by ERBB2 Signaling by SCF-KIT 3 genes Regulation of KIT signaling 1 genes Signaling by NTRKs Signaling by NTRK2 (TRKB) Activated NTRK2 signals through FYN NTRK2 activates RAC1 Signaling by VEGF VEGFA-VEGFR2 Pathway 1 genes VEGFA-VEGFR2 Pathway (1 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by NTRKs Signaling by NTRK1 (TRKA) Signalling to ERKs Signalling to RAS Signaling by VEGF VEGFA-VEGFR2 Pathway 1 genes CREB phosphorylation (1 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by NTRKs Signaling by NTRK1 (TRKA) Nuclear Events (kinase and transcription factor activation) CREB phosphorylation 1 genes FGFR1b ligand binding and activation (1 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by FGFR Signaling by FGFR1 FGFR1 ligand binding and activation FGFR1b ligand binding and activation 1 genes MET activates PTK2 signaling (5 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by PDGF 4 genes Signaling by MET MET promotes cell motility MET activates PTK2 signaling 1 genes NGF-stimulated transcription (1 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by NTRKs Signaling by NTRK1 (TRKA) Nuclear Events (kinase and transcription factor activation) NGF-stimulated transcription 1 genes NTRK2 activates RAC1 (2 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by NTRKs Signaling by NTRK2 (TRKB) Activated NTRK2 signals through FYN NTRK2 activates RAC1 2 genes Negative regulation of MET activity (2 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by EGFR EGFR downregulation Signaling by MET Negative regulation of MET activity 2 genes Downregulation of ERBB2:ERBB3 signaling (1 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by ERBB2 Downregulation of ERBB2 signaling Downregulation of ERBB2:ERBB3 signaling 1 genes FGFRL1 modulation of FGFR1 signaling (3 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by FGFR Signaling by FGFR1 FGFRL1 modulation of FGFR1 signaling 3 genes MET activates PTK2 signaling (5 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by MET MET promotes cell motility MET activates PTK2 signaling 5 genes NTF3 activates NTRK3 signaling (1 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by NTRKs Signaling by NTRK3 (TRKC) NTF3 activates NTRK3 signaling 1 genes Signaling by MST1 (1 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by MET MET Receptor Activation Signaling by MST1 1 genes VEGF binds to VEGFR leading to receptor dimerization (4 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by VEGF VEGF ligand-receptor interactions VEGF binds to VEGFR leading to receptor dimerization 4 genes VEGFR2 mediated vascular permeability (8 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by VEGF VEGFA-VEGFR2 Pathway VEGFR2 mediated vascular permeability 8 genes Downregulation of ERBB2 signaling (1 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by ERBB2 Downregulation of ERBB2 signaling 1 genes Nuclear signaling by ERBB4 (2 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by ERBB4 Nuclear signaling by ERBB4 2 genes VEGFA-VEGFR2 Pathway (8 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by VEGF VEGFA-VEGFR2 Pathway 8 genes Signaling by EGFR (1 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by EGFR 1 genes Signaling by SCF-KIT (2 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by SCF-KIT 2 genes	Axl Gene Information Basic Information Ensembl ID: ENSMUSG00000002602 Description: AXL receptor tyrosine kinase [Source:MGI Symbol;Acc:MGI:1347244] Location: 7:25456698-25488130 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast pericyte stem cell phagocyte stromal cell plasma cell kupffer cell macrophage Other: Signaling by Receptor Tyrosine Kinases Bcar1 Gene Information Basic Information Ensembl ID: ENSMUSG00000031955 Description: breast cancer anti-estrogen resistance 1 [Source:MGI Symbol;Acc:MGI:108091] Location: 8:112437106-112470441 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Integrin signaling Platelet activation, signaling and aggregation Signaling by Non-Receptor Tyrosine Kinases Bdnf Gene Information Basic Information Ensembl ID: ENSMUSG00000048482 Description: brain derived neurotrophic factor [Source:MGI Symbol;Acc:MGI:88145] Location: 2:109505045-109557352 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Cav1 Gene Information Basic Information Ensembl ID: ENSMUSG00000007655 Description: caveolin 1%2C caveolae protein [Source:MGI Symbol;Acc:MGI:102709] Location: 6:17306334-17341451 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by WNT Metabolism of nitric oxide: NOS3 activation and regulation Cell surface interactions at the vascular wall Cdc42 Gene Information Basic Information Ensembl ID: ENSMUSG00000006699 Description: cell division cycle 42 [Source:MGI Symbol;Acc:MGI:106211] Location: 4:137047007-137085031 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: hematopoietic stem cell phagocyte antigen presenting cell macrophage dendritic cell Other: Adaptive Immune System Innate Immune System Signaling by GPCR Cdh5 Gene Information Basic Information Ensembl ID: ENSMUSG00000031871 Description: cadherin 5 [Source:MGI Symbol;Acc:MGI:105057] Location: 8:104828257-104871143 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Cell junction organization Signaling by Receptor Tyrosine Kinases Col1a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000001506 Description: collagen%2C type I%2C alpha 1 [Source:MGI Symbol;Acc:MGI:88467] Location: 11:94827050-94843868 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stellate cell pericyte stromal cell stem cell valve interstitial cell mesenchymal cell endothelial cell Other: ECM proteoglycans Platelet Adhesion to exposed collagen Adaptive Immune System Col1a2 Gene Information Basic Information Ensembl ID: ENSMUSG00000029661 Description: collagen%2C type I%2C alpha 2 [Source:MGI Symbol;Acc:MGI:88468] Location: 6:4504814-4541544 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stellate cell pericyte stem cell stromal cell epithelial cell vascular cell meningeal cell Other: Adaptive Immune System Degradation of the extracellular matrix Collagen formation Col5a2 Gene Information Basic Information Ensembl ID: ENSMUSG00000026042 Description: collagen%2C type V%2C alpha 2 [Source:MGI Symbol;Acc:MGI:88458] Location: 1:45413481-45542442 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast pericyte stellate cell stromal cell mesenchymal cell Other: Degradation of the extracellular matrix Collagen formation Fibronectin matrix formation Col6a2 Gene Information Basic Information Ensembl ID: ENSMUSG00000020241 Description: collagen%2C type VI%2C alpha 2 [Source:MGI Symbol;Acc:MGI:88460] Location: 10:76431596-76459464 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stellate cell pericyte pneumocyte stromal cell epithelial cell Other: Degradation of the extracellular matrix Collagen formation Integrin cell surface interactions Col6a3 Gene Information Basic Information Ensembl ID: ENSMUSG00000048126 Description: collagen%2C type VI%2C alpha 3 [Source:MGI Symbol;Acc:MGI:88461] Location: 1:90693645-90771693 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast pericyte stellate cell stromal cell Other: Degradation of the extracellular matrix Collagen formation Integrin cell surface interactions Creb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000025958 Description: cAMP responsive element binding protein 1 [Source:MGI Symbol;Acc:MGI:88494] Location: 1:64571804-64643707 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Transmission across Chemical Synapses Cytokine Signaling in Immune system Innate Immune System Crkl Gene Information Basic Information Ensembl ID: ENSMUSG00000006134 Description: v-crk avian sarcoma virus CT10 oncogene homolog-like [Source:MGI Symbol;Acc:MGI:104686] Location: 16:17269851-17305298 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Signaling by Erythropoietin Signaling by Receptor Tyrosine Kinases Ctnna1 Gene Information Basic Information Ensembl ID: ENSMUSG00000037815 Description: catenin alpha 1 [Source:MGI Symbol;Acc:MGI:88274] Location: 18:35251912-35387832 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Cell junction organization Myogenesis Signaling by Receptor Tyrosine Kinases Ctnnb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000006932 Description: catenin beta 1 [Source:MGI Symbol;Acc:MGI:88276] Location: 9:120758282-120789573 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stem cell epithelial cell Other: Apoptosis Innate Immune System Signaling by WNT Ctnnd1 Gene Information Basic Information Ensembl ID: ENSMUSG00000034101 Description: catenin delta 1 [Source:MGI Symbol;Acc:MGI:105100] Location: 2:84430415-84481109 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cell junction organization Signaling by Receptor Tyrosine Kinases Cybb Gene Information Basic Information Ensembl ID: ENSMUSG00000015340 Description: cytochrome b-245%2C beta polypeptide [Source:MGI Symbol;Acc:MGI:88574] Location: X:9301491-9354010 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: monocyte Other: Adaptive Immune System Innate Immune System Cellular responses to stress Cyfip2 Gene Information Basic Information Ensembl ID: ENSMUSG00000020340 Description: cytoplasmic FMR1 interacting protein 2 [Source:MGI Symbol;Acc:MGI:1924134] Location: 11:46084677-46203686 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell neuron developing T cell Naive B cell Specialized T cell Other: Signaling by Receptor Tyrosine Kinases Innate Immune System Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Esr1 Gene Information Basic Information Ensembl ID: ENSMUSG00000019768 Description: estrogen receptor 1 (alpha) [Source:MGI Symbol;Acc:MGI:1352467] Location: 10:4561593-4955614 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by Receptor Tyrosine Kinases Cellular responses to stress Post-translational protein modification Fam83a Gene Information Basic Information Ensembl ID: ENSMUSG00000051225 Description: family with sequence similarity 83%2C member A [Source:MGI Symbol;Acc:MGI:2447773] Location: 15:57848815-57874405 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by Receptor Tyrosine Kinases Fgf10 Gene Information Basic Information Ensembl ID: ENSMUSG00000021732 Description: fibroblast growth factor 10 [Source:MGI Symbol;Acc:MGI:1099809] Location: 13:118806327-118928651 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: cochleovestibular ganglion cell Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Fgf7 Gene Information Basic Information Ensembl ID: ENSMUSG00000027208 Description: fibroblast growth factor 7 [Source:MGI Symbol;Acc:MGI:95521] Location: 2:125876578-125933105 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Fgfr1 Gene Information Basic Information Ensembl ID: ENSMUSG00000031565 Description: fibroblast growth factor receptor 1 [Source:MGI Symbol;Acc:MGI:95522] Location: 8:26003670-26065734 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast chondrocyte muscle cell osteoblast Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Fgfr3 Gene Information Basic Information Ensembl ID: ENSMUSG00000054252 Description: fibroblast growth factor receptor 3 [Source:MGI Symbol;Acc:MGI:95524] Location: 5:33879018-33894412 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell astrocyte supporting cell Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Fgfr4 Gene Information Basic Information Ensembl ID: ENSMUSG00000005320 Description: fibroblast growth factor receptor 4 [Source:MGI Symbol;Acc:MGI:95525] Location: 13:55300453-55316572 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stem cell muscle cell Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Fgfrl1 Gene Information Basic Information Ensembl ID: ENSMUSG00000008090 Description: fibroblast growth factor receptor-like 1 [Source:MGI Symbol;Acc:MGI:2150920] Location: 5:108840248-108854790 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by Receptor Tyrosine Kinases Flt1 Gene Information Basic Information Ensembl ID: ENSMUSG00000029648 Description: FMS-like tyrosine kinase 1 [Source:MGI Symbol;Acc:MGI:95558] Location: 5:147498414-147662821 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Signaling by Receptor Tyrosine Kinases Frs2 Gene Information Basic Information Ensembl ID: ENSMUSG00000020170 Description: fibroblast growth factor receptor substrate 2 [Source:MGI Symbol;Acc:MGI:1100860] Location: 10:116905332-116984439 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Fyn Gene Information Basic Information Ensembl ID: ENSMUSG00000019843 Description: Fyn proto-oncogene [Source:MGI Symbol;Acc:MGI:95602] Location: 10:39244851-39441377 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cell surface interactions at the vascular wall Nephrin family interactions Cytokine Signaling in Immune system Gab1 Gene Information Basic Information Ensembl ID: ENSMUSG00000031714 Description: growth factor receptor bound protein 2-associated protein 1 [Source:MGI Symbol;Acc:MGI:108088] Location: 8:81491063-81607148 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte Other: Signaling by Erythropoietin Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Grap Gene Information Basic Information Ensembl ID: ENSMUSG00000004837 Description: GRB2-related adaptor protein [Source:MGI Symbol;Acc:MGI:1918770] Location: 11:61544091-61563610 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: smooth muscle cell lymphocyte Other: Signaling by Receptor Tyrosine Kinases Irs2 Gene Information Basic Information Ensembl ID: ENSMUSG00000038894 Description: insulin receptor substrate 2 [Source:MGI Symbol;Acc:MGI:109334] Location: 8:11034681-11058458 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: mural cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades Signaling by Erythropoietin Itga2 Gene Information Basic Information Ensembl ID: ENSMUSG00000015533 Description: integrin alpha 2 [Source:MGI Symbol;Acc:MGI:96600] Location: 13:114969617-115068636 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Specialized T cell Other: Integrin cell surface interactions Non-integrin membrane-ECM interactions ECM proteoglycans Itga3 Gene Information Basic Information Ensembl ID: ENSMUSG00000001507 Description: integrin alpha 3 [Source:MGI Symbol;Acc:MGI:96602] Location: 11:94935300-94967627 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Cell surface interactions at the vascular wall Integrin cell surface interactions Laminin interactions Itgav Gene Information Basic Information Ensembl ID: ENSMUSG00000027087 Description: integrin alpha V [Source:MGI Symbol;Acc:MGI:96608] Location: 2:83554741-83637260 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell bone cell Other: ECM proteoglycans Non-integrin membrane-ECM interactions Adaptive Immune System Itgb3 Gene Information Basic Information Ensembl ID: ENSMUSG00000020689 Description: integrin beta 3 [Source:MGI Symbol;Acc:MGI:96612] Location: 11:104498826-104561302 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell stromal cell bone cell megakaryocyte Other: Elastic fibre formation Cell surface interactions at the vascular wall Integrin cell surface interactions Jak2 Gene Information Basic Information Ensembl ID: ENSMUSG00000024789 Description: Janus kinase 2 [Source:MGI Symbol;Acc:MGI:96629] Location: 19:29229228-29290480 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell dendritic cell eosinophil Other: Cytokine Signaling in Immune system MAPK family signaling cascades Cell Cycle, Mitotic Jup Gene Information Basic Information Ensembl ID: ENSMUSG00000001552 Description: junction plakoglobin [Source:MGI Symbol;Acc:MGI:96650] Location: 11:100259784-100288589 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stellate cell stem cell epithelial cell smooth muscle cell keratinocyte basal cell Other: Innate Immune System Cell junction organization Keratinization Kitl Gene Information Basic Information Ensembl ID: ENSMUSG00000019966 Description: kit ligand [Source:MGI Symbol;Acc:MGI:96974] Location: 10:99851492-99936278 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stromal cell Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Klb Gene Information Basic Information Ensembl ID: ENSMUSG00000029195 Description: klotho beta [Source:MGI Symbol;Acc:MGI:1932466] Location: 5:65505657-65541350 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: adipocyte Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Lyn Gene Information Basic Information Ensembl ID: ENSMUSG00000042228 Description: LYN proto-oncogene%2C Src family tyrosine kinase [Source:MGI Symbol;Acc:MGI:96892] Location: 4:3678115-3813122 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Platelet Adhesion to exposed collagen Cytokine Signaling in Immune system Adaptive Immune System Met Gene Information Basic Information Ensembl ID: ENSMUSG00000009376 Description: met proto-oncogene [Source:MGI Symbol;Acc:MGI:96969] Location: 6:17463799-17573979 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell intercalated cell Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Ncf1 Gene Information Basic Information Ensembl ID: ENSMUSG00000015950 Description: neutrophil cytosolic factor 1 [Source:MGI Symbol;Acc:MGI:97283] Location: 5:134248907-134258479 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell hematopoietic stem cell phagocyte granulocyte Other: Adaptive Immune System Innate Immune System Cellular responses to stress Ncf4 Gene Information Basic Information Ensembl ID: ENSMUSG00000071715 Description: neutrophil cytosolic factor 4 [Source:MGI Symbol;Acc:MGI:109186] Location: 15:78129001-78146780 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell dendritic cell erythrocyte granulocyte monocyte Other: Adaptive Immune System Innate Immune System Cellular responses to stress Ntf3 Gene Information Basic Information Ensembl ID: ENSMUSG00000049107 Description: neurotrophin 3 [Source:MGI Symbol;Acc:MGI:97380] Location: 6:126078375-126143873 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: smooth muscle cell Other: Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Ntrk1 Gene Information Basic Information Ensembl ID: ENSMUSG00000028072 Description: neurotrophic tyrosine kinase%2C receptor%2C type 1 [Source:MGI Symbol;Acc:MGI:97383] Location: 3:87685551-87702469 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast Other: Signaling by Receptor Tyrosine Kinases Ntrk2 Gene Information Basic Information Ensembl ID: ENSMUSG00000055254 Description: neurotrophic tyrosine kinase%2C receptor%2C type 2 [Source:MGI Symbol;Acc:MGI:97384] Location: 13:58954383-59281784 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast glial cell neuron astrocyte Other: Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Pak1 Gene Information Basic Information Ensembl ID: ENSMUSG00000030774 Description: p21 (RAC1) activated kinase 1 [Source:MGI Symbol;Acc:MGI:1339975] Location: 7:97437748-97561588 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell epithelial cell excitatory neuron Other: Adaptive Immune System Innate Immune System Signaling by GPCR Pgf Gene Information Basic Information Ensembl ID: ENSMUSG00000004791 Description: placental growth factor [Source:MGI Symbol;Acc:MGI:105095] Location: 12:85213409-85224564 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell endothelial cell smooth muscle cell Other: Signaling by Receptor Tyrosine Kinases Plat Gene Information Basic Information Ensembl ID: ENSMUSG00000031538 Description: plasminogen activator%2C tissue [Source:MGI Symbol;Acc:MGI:97610] Location: 8:23247743-23272860 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast endothelial cell pericyte epithelial cell stromal cell smooth muscle cell Other: Dissolution of Fibrin Clot Signaling by Receptor Tyrosine Kinases Plcg1 Gene Information Basic Information Ensembl ID: ENSMUSG00000016933 Description: phospholipase C%2C gamma 1 [Source:MGI Symbol;Acc:MGI:97615] Location: 2:160573220-160617680 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Inositol phosphate metabolism Ppp2ca Gene Information Basic Information Ensembl ID: ENSMUSG00000020349 Description: protein phosphatase 2 (formerly 2A)%2C catalytic subunit%2C alpha isoform [Source:MGI Symbol;Acc:MGI:1321159] Location: 11:51989508-52018605 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Prr5 Gene Information Basic Information Ensembl ID: ENSMUSG00000036106 Description: proline rich 5 (renal) [Source:MGI Symbol;Acc:MGI:1924714] Location: 15:84553821-84587874 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: plasma cell Other: Adaptive Immune System RNA Polymerase II Transcription Intracellular signaling by second messengers Psen1 Gene Information Basic Information Ensembl ID: ENSMUSG00000019969 Description: presenilin 1 [Source:MGI Symbol;Acc:MGI:1202717] Location: 12:83734926-83781973 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Signaling by NOTCH Death Receptor Signaling Ptpn11 Gene Information Basic Information Ensembl ID: ENSMUSG00000043733 Description: protein tyrosine phosphatase%2C non-receptor type 11 [Source:MGI Symbol;Acc:MGI:99511] Location: 5:121268596-121329460 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Nervous system development Cytokine Signaling in Immune system Adaptive Immune System Ptpn6 Gene Information Basic Information Ensembl ID: ENSMUSG00000004266 Description: protein tyrosine phosphatase%2C non-receptor type 6 [Source:MGI Symbol;Acc:MGI:96055] Location: 6:124697670-124715677 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell Naive B cell tuft cell monocyte dendritic cell macrophage Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Rapgef1 Gene Information Basic Information Ensembl ID: ENSMUSG00000039844 Description: Rap guanine nucleotide exchange factor (GEF) 1 [Source:MGI Symbol;Acc:MGI:104580] Location: 2:29509732-29630990 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Specialized T cell oligodendrocyte precursor cell Other: Signaling by Erythropoietin Cytokine Signaling in Immune system Signaling by Receptor Tyrosine Kinases Rnf41 Gene Information Basic Information Ensembl ID: ENSMUSG00000025373 Description: ring finger protein 41 [Source:MGI Symbol;Acc:MGI:1914838] Location: 10:128247526-128277310 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Adaptive Immune System Signaling by Receptor Tyrosine Kinases Sh2b3 Gene Information Basic Information Ensembl ID: ENSMUSG00000042594 Description: SH2B adaptor protein 3 [Source:MGI Symbol;Acc:MGI:893598] Location: 5:121953551-121975709 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Signaling by Receptor Tyrosine Kinases Factors involved in megakaryocyte development and platelet production Sh2d2a Gene Information Basic Information Ensembl ID: ENSMUSG00000028071 Description: SH2 domain containing 2A [Source:MGI Symbol;Acc:MGI:1351596] Location: 3:87754062-87763029 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell developing T cell leukocyte CD8+ T cell Other: Signaling by Receptor Tyrosine Kinases Sh3gl1 Gene Information Basic Information Ensembl ID: ENSMUSG00000003200 Description: SH3-domain GRB2-like 1 [Source:MGI Symbol;Acc:MGI:700010] Location: 17:56323750-56343635 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Membrane Trafficking Signaling by Receptor Tyrosine Kinases Shc1 Gene Information Basic Information Ensembl ID: ENSMUSG00000042626 Description: src homology 2 domain-containing transforming protein C1 [Source:MGI Symbol;Acc:MGI:98296] Location: 3:89325750-89337334 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Innate Immune System Cell surface interactions at the vascular wall Shc2 Gene Information Basic Information Ensembl ID: ENSMUSG00000020312 Description: SHC (Src homology 2 domain containing) transforming protein 2 [Source:MGI Symbol;Acc:MGI:106180] Location: 10:79453885-79473752 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: MAPK family signaling cascades Signaling by Receptor Tyrosine Kinases Sos1 Gene Information Basic Information Ensembl ID: ENSMUSG00000024241 Description: SOS Ras/Rac guanine nucleotide exchange factor 1 [Source:MGI Symbol;Acc:MGI:98354] Location: 17:80701180-80787882 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Spint1 Gene Information Basic Information Ensembl ID: ENSMUSG00000027315 Description: serine protease inhibitor%2C Kunitz type 1 [Source:MGI Symbol;Acc:MGI:1338033] Location: 2:119067843-119080008 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Signaling by Receptor Tyrosine Kinases Spred1 Gene Information Basic Information Ensembl ID: ENSMUSG00000027351 Description: sprouty protein with EVH-1 domain 1%2C related sequence [Source:MGI Symbol;Acc:MGI:2150016] Location: 2:116951855-117012760 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: adrenal cortical cell fibroblast Other: MAPK family signaling cascades Signaling by Receptor Tyrosine Kinases Spred2 Gene Information Basic Information Ensembl ID: ENSMUSG00000045671 Description: sprouty-related EVH1 domain containing 2 [Source:MGI Symbol;Acc:MGI:2150019] Location: 11:19874375-19974026 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: MAPK family signaling cascades Signaling by Receptor Tyrosine Kinases Srf Gene Information Basic Information Ensembl ID: ENSMUSG00000015605 Description: serum response factor [Source:MGI Symbol;Acc:MGI:106658] Location: 17:46859255-46867101 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endocrine cell smooth muscle cell Other: Signaling by Receptor Tyrosine Kinases Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Stub1 Gene Information Basic Information Ensembl ID: ENSMUSG00000039615 Description: STIP1 homology and U-Box containing protein 1 [Source:MGI Symbol;Acc:MGI:1891731] Location: 17:26049479-26052378 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Adaptive Immune System Regulated Necrosis RNA Polymerase II Transcription Tgfbr3 Gene Information Basic Information Ensembl ID: ENSMUSG00000029287 Description: transforming growth factor%2C beta receptor III [Source:MGI Symbol;Acc:MGI:104637] Location: 5:107254436-107437495 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: preadipocyte stellate cell stromal cell endothelial cell fibroblast mesenchymal cell Other: Signaling by Receptor Tyrosine Kinases Signaling by TGFB family members Thbs1 Gene Information Basic Information Ensembl ID: ENSMUSG00000040152 Description: thrombospondin 1 [Source:MGI Symbol;Acc:MGI:98737] Location: 2:117942357-117957614 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell fibroblast phagocyte epithelial cell monocyte mural cell megakaryocyte dendritic cell Other: Integrin cell surface interactions Post-translational protein modification Platelet activation, signaling and aggregation Tlr9 Gene Information Basic Information Ensembl ID: ENSMUSG00000045322 Description: toll-like receptor 9 [Source:MGI Symbol;Acc:MGI:1932389] Location: 9:106099797-106104082 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Signaling by Receptor Tyrosine Kinases Vegfa Gene Information Basic Information Ensembl ID: ENSMUSG00000023951 Description: vascular endothelial growth factor A [Source:MGI Symbol;Acc:MGI:103178] Location: 17:46327919-46343295 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell stellate cell mast cell stromal cell Other: Platelet activation, signaling and aggregation Signaling by Receptor Tyrosine Kinases Vegfc Gene Information Basic Information Ensembl ID: ENSMUSG00000031520 Description: vascular endothelial growth factor C [Source:MGI Symbol;Acc:MGI:109124] Location: 8:54530641-54640131 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Platelet activation, signaling and aggregation Signaling by Receptor Tyrosine Kinases
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Pathway Hierarchies & Genes RHOBTB2 GTPase cycle (1 genes) Signal Transduction Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Signaling by Rho GTPases RHO GTPase cycle RHOBTB GTPase Cycle RHOBTB2 GTPase cycle 1 genes CDC42 GTPase cycle (2 genes) Signal Transduction Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Signaling by Rho GTPases RHO GTPase cycle CDC42 GTPase cycle 2 genes RAC1 GTPase cycle (2 genes) Signal Transduction Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Signaling by Rho GTPases RHO GTPase cycle RAC1 GTPase cycle 2 genes RAC2 GTPase cycle (1 genes) Signal Transduction Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Signaling by Rho GTPases RHO GTPase cycle RAC2 GTPase cycle 1 genes RAC3 GTPase cycle (1 genes) Signal Transduction Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Signaling by Rho GTPases RHO GTPase cycle RAC3 GTPase cycle 1 genes RHO GTPases Activate Formins (7 genes) Signal Transduction Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Signaling by Rho GTPases RHO GTPase Effectors RHO GTPases Activate Formins 7 genes RHO GTPases Activate NADPH Oxidases (4 genes) Signal Transduction Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Signaling by Rho GTPases RHO GTPase Effectors RHO GTPases Activate NADPH Oxidases 4 genes RHO GTPases Activate WASPs and WAVEs (3 genes) Signal Transduction Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Signaling by Rho GTPases RHO GTPase Effectors RHO GTPases Activate WASPs and WAVEs 3 genes RHO GTPases activate CIT (1 genes) Signal Transduction Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Signaling by Rho GTPases RHO GTPase Effectors RHO GTPases activate CIT 1 genes RHO GTPases activate IQGAPs (4 genes) Signal Transduction Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Signaling by Rho GTPases RHO GTPase Effectors RHO GTPases activate IQGAPs 4 genes RHO GTPases activate KTN1 (1 genes) Signal Transduction Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Signaling by Rho GTPases RHO GTPase Effectors RHO GTPases activate KTN1 1 genes RHO GTPases activate PAKs (3 genes) Signal Transduction Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Signaling by Rho GTPases RHO GTPase Effectors RHO GTPases activate PAKs 3 genes RHO GTPases regulate CFTR trafficking (1 genes) Signal Transduction Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Signaling by Rho GTPases RHO GTPase Effectors RHO GTPases regulate CFTR trafficking 1 genes RHOA GTPase cycle (10 genes) Signal Transduction Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Signaling by Rho GTPases RHO GTPase cycle RHOA GTPase cycle 10 genes RHOD GTPase cycle (1 genes) Signal Transduction Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Signaling by Rho GTPases RHO GTPase cycle RHOD GTPase cycle 1 genes RHOQ GTPase cycle (1 genes) Signal Transduction Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Signaling by Rho GTPases RHO GTPase cycle RHOQ GTPase cycle 1 genes RND2 GTPase cycle (1 genes) Signal Transduction Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Signaling by Rho GTPases RHO GTPase cycle RND2 GTPase cycle 1 genes RND3 GTPase cycle (4 genes) Signal Transduction Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Signaling by Rho GTPases RHO GTPase cycle RND3 GTPase cycle 4 genes RHOBTB3 ATPase cycle (1 genes) Signal Transduction Signaling by Rho GTPases, Miro GTPases and RHOBTB3 RHOBTB3 ATPase cycle 1 genes	Abl1 Gene Information Basic Information Ensembl ID: ENSMUSG00000026842 Description: c-abl oncogene 1%2C non-receptor tyrosine kinase [Source:MGI Symbol;Acc:MGI:87859] Location: 2:31578388-31694239 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Epigenetic regulation of gene expression Myogenesis Abl2 Gene Information Basic Information Ensembl ID: ENSMUSG00000026596 Description: ABL proto-oncogene 2%2C non-receptor tyrosine kinase [Source:MGI Symbol;Acc:MGI:87860] Location: 1:156386356-156477138 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: bone cell Other: Cytokine Signaling in Immune system Nervous system development Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Arhgap30 Gene Information Basic Information Ensembl ID: ENSMUSG00000048865 Description: Rho GTPase activating protein 30 [Source:MGI Symbol;Acc:MGI:2684948] Location: 1:171216522-171237866 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Naive B cell monocyte leukocyte Other: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Arhgef1 Gene Information Basic Information Ensembl ID: ENSMUSG00000040940 Description: Rho guanine nucleotide exchange factor 1 [Source:MGI Symbol;Acc:MGI:1353510] Location: 7:24602337-24626019 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell CD4+ T cell Specialized T cell CD8+ T cell lymphocyte Other: Signaling by GPCR Death Receptor Signaling Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Arhgef11 Gene Information Basic Information Ensembl ID: ENSMUSG00000041977 Description: Rho guanine nucleotide exchange factor 11 [Source:MGI Symbol;Acc:MGI:2441869] Location: 3:87524866-87645341 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by GPCR Death Receptor Signaling Nervous system development Arhgef2 Gene Information Basic Information Ensembl ID: ENSMUSG00000028059 Description: Rho/Rac guanine nucleotide exchange factor 2 [Source:MGI Symbol;Acc:MGI:103264] Location: 3:88513273-88555359 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Death Receptor Signaling Signaling by GPCR Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Bcr Gene Information Basic Information Ensembl ID: ENSMUSG00000009681 Description: BCR activator of RhoGEF and GTPase [Source:MGI Symbol;Acc:MGI:88141] Location: 10:74896424-75020753 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte stellate cell endothelial cell fibroblast Other: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Btk Gene Information Basic Information Ensembl ID: ENSMUSG00000031264 Description: Bruton agammaglobulinemia tyrosine kinase [Source:MGI Symbol;Acc:MGI:88216] Location: X:133443085-133484319 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Naive B cell Other: Adaptive Immune System Innate Immune System Signaling by GPCR Cav1 Gene Information Basic Information Ensembl ID: ENSMUSG00000007655 Description: caveolin 1%2C caveolae protein [Source:MGI Symbol;Acc:MGI:102709] Location: 6:17306334-17341451 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by WNT Metabolism of nitric oxide: NOS3 activation and regulation Cell surface interactions at the vascular wall Ccdc88a Gene Information Basic Information Ensembl ID: ENSMUSG00000032740 Description: coiled coil domain containing 88A [Source:MGI Symbol;Acc:MGI:1925177] Location: 11:29323658-29460808 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast dendritic cell oligodendrocyte precursor cell neuron monocyte Other: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Cdc42 Gene Information Basic Information Ensembl ID: ENSMUSG00000006699 Description: cell division cycle 42 [Source:MGI Symbol;Acc:MGI:106211] Location: 4:137047007-137085031 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: hematopoietic stem cell phagocyte antigen presenting cell macrophage dendritic cell Other: Adaptive Immune System Innate Immune System Signaling by GPCR Ckap4 Gene Information Basic Information Ensembl ID: ENSMUSG00000046841 Description: cytoskeleton-associated protein 4 [Source:MGI Symbol;Acc:MGI:2444926] Location: 10:84362169-84369926 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell fibroblast smooth muscle cell granulocyte epithelial cell osteoblast Other: Innate Immune System Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Surfactant metabolism Ctnna1 Gene Information Basic Information Ensembl ID: ENSMUSG00000037815 Description: catenin alpha 1 [Source:MGI Symbol;Acc:MGI:88274] Location: 18:35251912-35387832 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Cell junction organization Myogenesis Signaling by Receptor Tyrosine Kinases Ctnnb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000006932 Description: catenin beta 1 [Source:MGI Symbol;Acc:MGI:88276] Location: 9:120758282-120789573 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stem cell epithelial cell Other: Apoptosis Innate Immune System Signaling by WNT Cybb Gene Information Basic Information Ensembl ID: ENSMUSG00000015340 Description: cytochrome b-245%2C beta polypeptide [Source:MGI Symbol;Acc:MGI:88574] Location: X:9301491-9354010 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: monocyte Other: Adaptive Immune System Innate Immune System Cellular responses to stress Cyfip2 Gene Information Basic Information Ensembl ID: ENSMUSG00000020340 Description: cytoplasmic FMR1 interacting protein 2 [Source:MGI Symbol;Acc:MGI:1924134] Location: 11:46084677-46203686 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell neuron developing T cell Naive B cell Specialized T cell Other: Signaling by Receptor Tyrosine Kinases Innate Immune System Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Ddx39b Gene Information Basic Information Ensembl ID: ENSMUSG00000019432 Description: DEAD box helicase 39b [Source:MGI Symbol;Acc:MGI:99240] Location: 17:35460722-35472683 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: progenitor cell skeletal muscle cell Other: Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Dlg4 Gene Information Basic Information Ensembl ID: ENSMUSG00000020886 Description: discs large MAGUK scaffold protein 4 [Source:MGI Symbol;Acc:MGI:1277959] Location: 11:69907768-69938348 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: photoreceptor cell Other: Transmission across Chemical Synapses LGI-ADAM interactions MAPK family signaling cascades Dock10 Gene Information Basic Information Ensembl ID: ENSMUSG00000038608 Description: dedicator of cytokinesis 10 [Source:MGI Symbol;Acc:MGI:2146320] Location: 1:80478790-80736244 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell developing T cell hematopoietic stem cell dendritic cell antigen presenting cell Specialized T cell monocyte oligodendrocyte Other: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Factors involved in megakaryocyte development and platelet production Dsg2 Gene Information Basic Information Ensembl ID: ENSMUSG00000044393 Description: desmoglein 2 [Source:MGI Symbol;Acc:MGI:1196466] Location: 18:20691131-20737578 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell tuft cell epithelial cell Other: Apoptosis Keratinization Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Dsp Gene Information Basic Information Ensembl ID: ENSMUSG00000054889 Description: desmoplakin [Source:MGI Symbol;Acc:MGI:109611] Location: 13:38335270-38382553 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell tuft cell skeletal muscle cell basal cell Other: Apoptosis Innate Immune System Keratinization Dvl1 Gene Information Basic Information Ensembl ID: ENSMUSG00000029071 Description: dishevelled segment polarity protein 1 [Source:MGI Symbol;Acc:MGI:94941] Location: 4:155931859-155943760 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by WNT Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Dvl2 Gene Information Basic Information Ensembl ID: ENSMUSG00000020888 Description: dishevelled segment polarity protein 2 [Source:MGI Symbol;Acc:MGI:106613] Location: 11:69891421-69903127 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by Hippo Membrane Trafficking Signaling by WNT Dvl3 Gene Information Basic Information Ensembl ID: ENSMUSG00000003233 Description: dishevelled segment polarity protein 3 [Source:MGI Symbol;Acc:MGI:108100] Location: 16:20335732-20352760 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by WNT Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Efhd2 Gene Information Basic Information Ensembl ID: ENSMUSG00000040659 Description: EF hand domain containing 2 [Source:MGI Symbol;Acc:MGI:106504] Location: 4:141585453-141602231 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell phagocyte monocyte macrophage leukocyte Other: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Flna Gene Information Basic Information Ensembl ID: ENSMUSG00000031328 Description: filamin%2C alpha [Source:MGI Symbol;Acc:MGI:95556] Location: X:73267067-73293426 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte endothelial cell stem cell smooth muscle cell fibroblast monocyte epithelial cell neutrophil mural cell Other: Cell junction organization Platelet activation, signaling and aggregation Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Frs2 Gene Information Basic Information Ensembl ID: ENSMUSG00000020170 Description: fibroblast growth factor receptor substrate 2 [Source:MGI Symbol;Acc:MGI:1100860] Location: 10:116905332-116984439 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Gna13 Gene Information Basic Information Ensembl ID: ENSMUSG00000020611 Description: guanine nucleotide binding protein%2C alpha 13 [Source:MGI Symbol;Acc:MGI:95768] Location: 11:109253657-109292195 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell developing T cell innate lymphoid cell Other: Signaling by GPCR Death Receptor Signaling Platelet activation, signaling and aggregation Gopc Gene Information Basic Information Ensembl ID: ENSMUSG00000019861 Description: golgi associated PDZ and coiled-coil motif containing [Source:MGI Symbol;Acc:MGI:2149946] Location: 10:52211946-52258220 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Iqgap1 Gene Information Basic Information Ensembl ID: ENSMUSG00000030536 Description: IQ motif containing GTPase activating protein 1 [Source:MGI Symbol;Acc:MGI:1352757] Location: 7:80361331-80475722 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell phagocyte epithelial cell macrophage monocyte granulocyte neutrophil Other: Innate Immune System Nephrin family interactions MAPK family signaling cascades Jup Gene Information Basic Information Ensembl ID: ENSMUSG00000001552 Description: junction plakoglobin [Source:MGI Symbol;Acc:MGI:96650] Location: 11:100259784-100288589 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stellate cell stem cell epithelial cell smooth muscle cell keratinocyte basal cell Other: Innate Immune System Cell junction organization Keratinization Men1 Gene Information Basic Information Ensembl ID: ENSMUSG00000024947 Description: multiple endocrine neoplasia 1 [Source:MGI Symbol;Acc:MGI:1316736] Location: 19:6385009-6390921 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by WNT Epigenetic regulation of gene expression Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Myh9 Gene Information Basic Information Ensembl ID: ENSMUSG00000022443 Description: myosin%2C heavy polypeptide 9%2C non-muscle [Source:MGI Symbol;Acc:MGI:107717] Location: 15:77644787-77726375 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell stromal cell Other: Innate Immune System Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Ncf1 Gene Information Basic Information Ensembl ID: ENSMUSG00000015950 Description: neutrophil cytosolic factor 1 [Source:MGI Symbol;Acc:MGI:97283] Location: 5:134248907-134258479 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell hematopoietic stem cell phagocyte granulocyte Other: Adaptive Immune System Innate Immune System Cellular responses to stress Ncf4 Gene Information Basic Information Ensembl ID: ENSMUSG00000071715 Description: neutrophil cytosolic factor 4 [Source:MGI Symbol;Acc:MGI:109186] Location: 15:78129001-78146780 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell dendritic cell erythrocyte granulocyte monocyte Other: Adaptive Immune System Innate Immune System Cellular responses to stress Nup85 Gene Information Basic Information Ensembl ID: ENSMUSG00000020739 Description: nucleoporin 85 [Source:MGI Symbol;Acc:MGI:3046173] Location: 11:115455260-115474811 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: bone cell Other: Metabolism of non-coding RNA Gene Silencing by RNA Cellular responses to stress Ophn1 Gene Information Basic Information Ensembl ID: ENSMUSG00000031214 Description: oligophrenin 1 [Source:MGI Symbol;Acc:MGI:2151070] Location: X:97597883-97934631 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: adipocyte myeloid cell Other: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Pak1 Gene Information Basic Information Ensembl ID: ENSMUSG00000030774 Description: p21 (RAC1) activated kinase 1 [Source:MGI Symbol;Acc:MGI:1339975] Location: 7:97437748-97561588 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell epithelial cell excitatory neuron Other: Adaptive Immune System Innate Immune System Signaling by GPCR Pkp4 Gene Information Basic Information Ensembl ID: ENSMUSG00000026991 Description: plakophilin 4 [Source:MGI Symbol;Acc:MGI:109281] Location: 2:58991194-59185552 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell endothelial cell Other: Keratinization Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Plin3 Gene Information Basic Information Ensembl ID: ENSMUSG00000024197 Description: perilipin 3 [Source:MGI Symbol;Acc:MGI:1914155] Location: 17:56584476-56599873 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: lymphoid progenitor cell Other: Membrane Trafficking Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Ppp2ca Gene Information Basic Information Ensembl ID: ENSMUSG00000020349 Description: protein phosphatase 2 (formerly 2A)%2C catalytic subunit%2C alpha isoform [Source:MGI Symbol;Acc:MGI:1321159] Location: 11:51989508-52018605 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Rac2 Gene Information Basic Information Ensembl ID: ENSMUSG00000033220 Description: Rac family small GTPase 2 [Source:MGI Symbol;Acc:MGI:97846] Location: 15:78443367-78456983 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell dendritic cell developing T cell tuft cell CD4+ T cell mast cell T cell granulocyte leukocyte lymphocyte Other: Innate Immune System Signaling by WNT Platelet activation, signaling and aggregation Rapgef1 Gene Information Basic Information Ensembl ID: ENSMUSG00000039844 Description: Rap guanine nucleotide exchange factor (GEF) 1 [Source:MGI Symbol;Acc:MGI:104580] Location: 2:29509732-29630990 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Specialized T cell oligodendrocyte precursor cell Other: Signaling by Erythropoietin Cytokine Signaling in Immune system Signaling by Receptor Tyrosine Kinases Scrib Gene Information Basic Information Ensembl ID: ENSMUSG00000022568 Description: scribbled planar cell polarity [Source:MGI Symbol;Acc:MGI:2145950] Location: 15:75919007-75941633 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Sos1 Gene Information Basic Information Ensembl ID: ENSMUSG00000024241 Description: SOS Ras/Rac guanine nucleotide exchange factor 1 [Source:MGI Symbol;Acc:MGI:98354] Location: 17:80701180-80787882 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Srf Gene Information Basic Information Ensembl ID: ENSMUSG00000015605 Description: serum response factor [Source:MGI Symbol;Acc:MGI:106658] Location: 17:46859255-46867101 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endocrine cell smooth muscle cell Other: Signaling by Receptor Tyrosine Kinases Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Stard13 Gene Information Basic Information Ensembl ID: ENSMUSG00000016128 Description: StAR related lipid transfer domain containing 13 [Source:MGI Symbol;Acc:MGI:2385331] Location: 5:150960975-151157301 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Tjp2 Gene Information Basic Information Ensembl ID: ENSMUSG00000024812 Description: tight junction protein 2 [Source:MGI Symbol;Acc:MGI:1341872] Location: 19:24071869-24202394 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron epithelial cell Other: Apoptosis Signaling by Hippo Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Zw10 Gene Information Basic Information Ensembl ID: ENSMUSG00000032264 Description: zw10 kinetochore protein [Source:MGI Symbol;Acc:MGI:1349478] Location: 9:48966913-48990075 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Membrane Trafficking Cell Cycle, Mitotic Cell Cycle Checkpoints
Signaling by TGFB family members Pathway Hierarchies & Genes TGFBR3 PTM regulation (4 genes) Signal Transduction Signaling by TGFB family members Signaling by Activin Signaling by TGF-beta Receptor Complex TGF-beta receptor signaling activates SMADs Signaling by BMP 3 genes Signaling by TGFBR3 TGFBR3 PTM regulation 1 genes TGFBR3 regulates TGF-beta signaling (7 genes) Signal Transduction Signaling by TGFB family members Signaling by TGF-beta Receptor Complex TGF-beta receptor signaling activates SMADs Downregulation of TGF-beta receptor signaling 2 genes Signaling by TGFBR3 2 genes TGFBR3 regulates TGF-beta signaling 3 genes TGFBR3 regulates TGF-beta signaling (5 genes) Signal Transduction Signaling by TGFB family members Signaling by TGF-beta Receptor Complex TGF-beta receptor signaling activates SMADs 4 genes Signaling by TGFBR3 TGFBR3 regulates TGF-beta signaling 1 genes SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (1 genes) Signal Transduction Signaling by TGFB family members Signaling by TGF-beta Receptor Complex Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 1 genes Signaling by BMP (3 genes) Signal Transduction Signaling by TGFB family members Signaling by TGF-beta Receptor Complex TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 2 genes Signaling by BMP 1 genes TGFBR3 PTM regulation (1 genes) Signal Transduction Signaling by TGFB family members Signaling by TGFBR3 TGFBR3 PTM regulation 1 genes TGFBR3 regulates TGF-beta signaling (2 genes) Signal Transduction Signaling by TGFB family members Signaling by TGFBR3 TGFBR3 regulates TGF-beta signaling 2 genes Signaling by BMP (1 genes) Signal Transduction Signaling by TGFB family members Signaling by BMP 1 genes	Acvr2a Gene Information Basic Information Ensembl ID: ENSMUSG00000052155 Description: activin receptor IIA [Source:MGI Symbol;Acc:MGI:102806] Location: 2:48704121-48793281 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Signaling by TGFB family members Arrb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000018909 Description: arrestin%2C beta 1 [Source:MGI Symbol;Acc:MGI:99473] Location: 7:99184673-99255978 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stromal cell Other: Membrane Trafficking Signaling by GPCR Signaling by Hedgehog Arrb2 Gene Information Basic Information Ensembl ID: ENSMUSG00000060216 Description: arrestin%2C beta 2 [Source:MGI Symbol;Acc:MGI:99474] Location: 11:70323461-70331654 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell antigen presenting cell Other: Signaling by WNT Membrane Trafficking Signaling by GPCR Bambi Gene Information Basic Information Ensembl ID: ENSMUSG00000024232 Description: BMP and activin membrane-bound inhibitor [Source:MGI Symbol;Acc:MGI:1915260] Location: 18:3507923-3516404 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: ectodermal cell osteoblast Other: Signaling by TGFB family members F11r Gene Information Basic Information Ensembl ID: ENSMUSG00000038235 Description: F11 receptor [Source:MGI Symbol;Acc:MGI:1321398] Location: 1:171265103-171292171 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stem cell phagocyte epithelial cell Other: Cell surface interactions at the vascular wall Integrin cell surface interactions Cell junction organization Itga8 Gene Information Basic Information Ensembl ID: ENSMUSG00000026768 Description: integrin alpha 8 [Source:MGI Symbol;Acc:MGI:109442] Location: 2:12111443-12306733 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast smooth muscle cell epithelial cell mesenchymal stem cell Other: Elastic fibre formation Integrin cell surface interactions ECM proteoglycans Itgav Gene Information Basic Information Ensembl ID: ENSMUSG00000027087 Description: integrin alpha V [Source:MGI Symbol;Acc:MGI:96608] Location: 2:83554741-83637260 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell bone cell Other: ECM proteoglycans Non-integrin membrane-ECM interactions Adaptive Immune System Itgb3 Gene Information Basic Information Ensembl ID: ENSMUSG00000020689 Description: integrin beta 3 [Source:MGI Symbol;Acc:MGI:96612] Location: 11:104498826-104561302 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell stromal cell bone cell megakaryocyte Other: Elastic fibre formation Cell surface interactions at the vascular wall Integrin cell surface interactions Men1 Gene Information Basic Information Ensembl ID: ENSMUSG00000024947 Description: multiple endocrine neoplasia 1 [Source:MGI Symbol;Acc:MGI:1316736] Location: 19:6385009-6390921 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by WNT Epigenetic regulation of gene expression Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Pard3 Gene Information Basic Information Ensembl ID: ENSMUSG00000025812 Description: par-3 family cell polarity regulator [Source:MGI Symbol;Acc:MGI:2135608] Location: 8:127790643-128338767 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell motor neuron Other: Cell junction organization Signaling by TGFB family members Psen1 Gene Information Basic Information Ensembl ID: ENSMUSG00000019969 Description: presenilin 1 [Source:MGI Symbol;Acc:MGI:1202717] Location: 12:83734926-83781973 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Signaling by NOTCH Death Receptor Signaling Smad2 Gene Information Basic Information Ensembl ID: ENSMUSG00000024563 Description: SMAD family member 2 [Source:MGI Symbol;Acc:MGI:108051] Location: 18:76374651-76444034 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Post-translational protein modification Signaling by NODAL RNA Polymerase II Transcription Smad3 Gene Information Basic Information Ensembl ID: ENSMUSG00000032402 Description: SMAD family member 3 [Source:MGI Symbol;Acc:MGI:1201674] Location: 9:63554049-63665276 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Specialized T cell Other: Signaling by NODAL Post-translational protein modification RNA Polymerase II Transcription Smad6 Gene Information Basic Information Ensembl ID: ENSMUSG00000036867 Description: SMAD family member 6 [Source:MGI Symbol;Acc:MGI:1336883] Location: 9:63860358-63929341 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell smooth muscle cell Other: Signaling by TGFB family members Smad7 Gene Information Basic Information Ensembl ID: ENSMUSG00000025880 Description: SMAD family member 7 [Source:MGI Symbol;Acc:MGI:1100518] Location: 18:75500600-75529006 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: mast cell endothelial cell Other: Post-translational protein modification RNA Polymerase II Transcription Signaling by TGFB family members Smurf1 Gene Information Basic Information Ensembl ID: ENSMUSG00000038780 Description: SMAD specific E3 ubiquitin protein ligase 1 [Source:MGI Symbol;Acc:MGI:1923038] Location: 5:144813305-144902657 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Adaptive Immune System Signaling by WNT Signaling by Hedgehog Smurf2 Gene Information Basic Information Ensembl ID: ENSMUSG00000018363 Description: SMAD specific E3 ubiquitin protein ligase 2 [Source:MGI Symbol;Acc:MGI:1913563] Location: 11:106710892-106811541 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Adaptive Immune System Signaling by WNT Signaling by Hedgehog Stub1 Gene Information Basic Information Ensembl ID: ENSMUSG00000039615 Description: STIP1 homology and U-Box containing protein 1 [Source:MGI Symbol;Acc:MGI:1891731] Location: 17:26049479-26052378 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Adaptive Immune System Regulated Necrosis RNA Polymerase II Transcription Tgfb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000002603 Description: transforming growth factor%2C beta 1 [Source:MGI Symbol;Acc:MGI:98725] Location: 7:25386427-25404502 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell hematopoietic stem cell phagocyte monocyte leukocyte megakaryocyte Other: Cell surface interactions at the vascular wall Non-integrin membrane-ECM interactions Elastic fibre formation Tgfb2 Gene Information Basic Information Ensembl ID: ENSMUSG00000039239 Description: transforming growth factor%2C beta 2 [Source:MGI Symbol;Acc:MGI:98726] Location: 1:186354989-186438186 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: glial cell endothelial cell astrocyte Other: Elastic fibre formation Platelet activation, signaling and aggregation Signaling by TGFB family members Tgfb3 Gene Information Basic Information Ensembl ID: ENSMUSG00000021253 Description: transforming growth factor%2C beta 3 [Source:MGI Symbol;Acc:MGI:98727] Location: 12:86103519-86125815 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: mesothelial cell Other: Elastic fibre formation Platelet activation, signaling and aggregation Signaling by TGFB family members Tgfbr1 Gene Information Basic Information Ensembl ID: ENSMUSG00000007613 Description: transforming growth factor%2C beta receptor I [Source:MGI Symbol;Acc:MGI:98728] Location: 4:47353222-47414931 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte microglia Other: Post-translational protein modification Signaling by TGFB family members Tgfbr2 Gene Information Basic Information Ensembl ID: ENSMUSG00000032440 Description: transforming growth factor%2C beta receptor II [Source:MGI Symbol;Acc:MGI:98729] Location: 9:115913361-116004428 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell fibroblast Other: Signaling by TGFB family members Tgfbr3 Gene Information Basic Information Ensembl ID: ENSMUSG00000029287 Description: transforming growth factor%2C beta receptor III [Source:MGI Symbol;Acc:MGI:104637] Location: 5:107254436-107437495 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: preadipocyte stellate cell stromal cell endothelial cell fibroblast mesenchymal cell Other: Signaling by Receptor Tyrosine Kinases Signaling by TGFB family members
Signaling by WNT Pathway Hierarchies & Genes Ca2+ pathway (3 genes) Signal Transduction Signaling by WNT Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade TCF dependent signaling in response to WNT Formation of the beta-catenin:TCF transactivating complex 2 genes Beta-catenin independent WNT signaling Ca2+ pathway 1 genes Ca2+ pathway (1 genes) Signal Transduction Signaling by WNT Degradation of beta-catenin by the destruction complex Repression of WNT target genes TCF dependent signaling in response to WNT Formation of the beta-catenin:TCF transactivating complex Beta-catenin independent WNT signaling Ca2+ pathway 1 genes Asymmetric localization of PCP proteins (3 genes) Signal Transduction Signaling by WNT TCF dependent signaling in response to WNT WNT mediated activation of DVL Beta-catenin independent WNT signaling PCP/CE pathway 2 genes Asymmetric localization of PCP proteins 1 genes Asymmetric localization of PCP proteins (3 genes) Signal Transduction Signaling by WNT TCF dependent signaling in response to WNT 1 genes WNT ligand biogenesis and trafficking 1 genes Beta-catenin independent WNT signaling PCP/CE pathway Asymmetric localization of PCP proteins 1 genes Asymmetric localization of PCP proteins (3 genes) Signal Transduction Signaling by WNT TCF dependent signaling in response to WNT Disassembly of the destruction complex and recruitment of AXIN to the membrane 1 genes Beta-catenin independent WNT signaling 1 genes PCP/CE pathway Asymmetric localization of PCP proteins 1 genes Asymmetric localization of PCP proteins (1 genes) Signal Transduction Signaling by WNT TCF dependent signaling in response to WNT Degradation of AXIN Beta-catenin independent WNT signaling PCP/CE pathway Asymmetric localization of PCP proteins 1 genes Asymmetric localization of PCP proteins (6 genes) Signal Transduction Signaling by WNT TCF dependent signaling in response to WNT Regulation of FZD by ubiquitination 4 genes Beta-catenin independent WNT signaling PCP/CE pathway 1 genes Asymmetric localization of PCP proteins 1 genes Asymmetric localization of PCP proteins (3 genes) Signal Transduction Signaling by WNT Beta-catenin independent WNT signaling PCP/CE pathway Asymmetric localization of PCP proteins 3 genes Ca2+ pathway (14 genes) Signal Transduction Signaling by WNT WNT ligand biogenesis and trafficking 11 genes Beta-catenin independent WNT signaling Ca2+ pathway 3 genes WNT5A-dependent internalization of FZD4 (1 genes) Signal Transduction Signaling by WNT Beta-catenin independent WNT signaling PCP/CE pathway WNT5A-dependent internalization of FZD4 1 genes Ca2+ pathway (3 genes) Signal Transduction Signaling by WNT Beta-catenin independent WNT signaling Ca2+ pathway 3 genes Deactivation of the beta-catenin transactivating complex (2 genes) Signal Transduction Signaling by WNT TCF dependent signaling in response to WNT Deactivation of the beta-catenin transactivating complex 2 genes Degradation of DVL (1 genes) Signal Transduction Signaling by WNT TCF dependent signaling in response to WNT Degradation of DVL 1 genes Formation of the beta-catenin:TCF transactivating complex (1 genes) Signal Transduction Signaling by WNT TCF dependent signaling in response to WNT Formation of the beta-catenin:TCF transactivating complex 1 genes Negative regulation of TCF-dependent signaling by WNT ligand antagonists (2 genes) Signal Transduction Signaling by WNT TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists 2 genes PCP/CE pathway (1 genes) Signal Transduction Signaling by WNT Beta-catenin independent WNT signaling PCP/CE pathway 1 genes	Arrb2 Gene Information Basic Information Ensembl ID: ENSMUSG00000060216 Description: arrestin%2C beta 2 [Source:MGI Symbol;Acc:MGI:99474] Location: 11:70323461-70331654 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell antigen presenting cell Other: Signaling by WNT Membrane Trafficking Signaling by GPCR Cav1 Gene Information Basic Information Ensembl ID: ENSMUSG00000007655 Description: caveolin 1%2C caveolae protein [Source:MGI Symbol;Acc:MGI:102709] Location: 6:17306334-17341451 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by WNT Metabolism of nitric oxide: NOS3 activation and regulation Cell surface interactions at the vascular wall Ctnnb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000006932 Description: catenin beta 1 [Source:MGI Symbol;Acc:MGI:88276] Location: 9:120758282-120789573 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stem cell epithelial cell Other: Apoptosis Innate Immune System Signaling by WNT Dact1 Gene Information Basic Information Ensembl ID: ENSMUSG00000044548 Description: dishevelled-binding antagonist of beta-catenin 1 [Source:MGI Symbol;Acc:MGI:1891740] Location: 12:71356658-71366881 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by WNT Dvl1 Gene Information Basic Information Ensembl ID: ENSMUSG00000029071 Description: dishevelled segment polarity protein 1 [Source:MGI Symbol;Acc:MGI:94941] Location: 4:155931859-155943760 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by WNT Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Dvl2 Gene Information Basic Information Ensembl ID: ENSMUSG00000020888 Description: dishevelled segment polarity protein 2 [Source:MGI Symbol;Acc:MGI:106613] Location: 11:69891421-69903127 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by Hippo Membrane Trafficking Signaling by WNT Dvl3 Gene Information Basic Information Ensembl ID: ENSMUSG00000003233 Description: dishevelled segment polarity protein 3 [Source:MGI Symbol;Acc:MGI:108100] Location: 16:20335732-20352760 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by WNT Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Fzd1 Gene Information Basic Information Ensembl ID: ENSMUSG00000044674 Description: frizzled class receptor 1 [Source:MGI Symbol;Acc:MGI:1196625] Location: 5:4803839-4808035 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by WNT Fzd4 Gene Information Basic Information Ensembl ID: ENSMUSG00000049791 Description: frizzled class receptor 4 [Source:MGI Symbol;Acc:MGI:108520] Location: 7:89053563-89062342 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Signaling by WNT Membrane Trafficking Fzd6 Gene Information Basic Information Ensembl ID: ENSMUSG00000022297 Description: frizzled class receptor 6 [Source:MGI Symbol;Acc:MGI:108474] Location: 15:38869429-38901583 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell pericyte Other: Signaling by WNT Fzd7 Gene Information Basic Information Ensembl ID: ENSMUSG00000041075 Description: frizzled class receptor 7 [Source:MGI Symbol;Acc:MGI:108570] Location: 1:59521583-59526114 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by WNT Gnao1 Gene Information Basic Information Ensembl ID: ENSMUSG00000031748 Description: guanine nucleotide binding protein%2C alpha O [Source:MGI Symbol;Acc:MGI:95775] Location: 8:94536594-94696016 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Signaling by WNT Gngt2 Gene Information Basic Information Ensembl ID: ENSMUSG00000038811 Description: guanine nucleotide binding protein (G protein)%2C gamma transducing activity polypeptide 2 [Source:MGI Symbol;Acc:MGI:893584] Location: 11:95728042-95736560 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell dendritic cell phagocyte monocyte myeloid cell plasma cell macrophage photoreceptor cell Other: Platelet homeostasis Transmission across Chemical Synapses Potassium Channels Gsk3b Gene Information Basic Information Ensembl ID: ENSMUSG00000022812 Description: glycogen synthase kinase 3 beta [Source:MGI Symbol;Acc:MGI:1861437] Location: 16:37909363-38066446 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by WNT Epigenetic regulation of gene expression Cellular responses to stress Lrp5 Gene Information Basic Information Ensembl ID: ENSMUSG00000024913 Description: low density lipoprotein receptor-related protein 5 [Source:MGI Symbol;Acc:MGI:1278315] Location: 19:3634828-3736564 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by WNT Lrp6 Gene Information Basic Information Ensembl ID: ENSMUSG00000030201 Description: low density lipoprotein receptor-related protein 6 [Source:MGI Symbol;Acc:MGI:1298218] Location: 6:134423439-134543928 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by WNT Map3k7 Gene Information Basic Information Ensembl ID: ENSMUSG00000028284 Description: mitogen-activated protein kinase kinase kinase 7 [Source:MGI Symbol;Acc:MGI:1346877] Location: 4:31964097-32023467 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Men1 Gene Information Basic Information Ensembl ID: ENSMUSG00000024947 Description: multiple endocrine neoplasia 1 [Source:MGI Symbol;Acc:MGI:1316736] Location: 19:6385009-6390921 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by WNT Epigenetic regulation of gene expression Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Ppp2ca Gene Information Basic Information Ensembl ID: ENSMUSG00000020349 Description: protein phosphatase 2 (formerly 2A)%2C catalytic subunit%2C alpha isoform [Source:MGI Symbol;Acc:MGI:1321159] Location: 11:51989508-52018605 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Prickle1 Gene Information Basic Information Ensembl ID: ENSMUSG00000036158 Description: prickle planar cell polarity protein 1 [Source:MGI Symbol;Acc:MGI:1916034] Location: 15:93396995-93493772 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell excitatory neuron Other: Signaling by WNT Rac2 Gene Information Basic Information Ensembl ID: ENSMUSG00000033220 Description: Rac family small GTPase 2 [Source:MGI Symbol;Acc:MGI:97846] Location: 15:78443367-78456983 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell dendritic cell developing T cell tuft cell CD4+ T cell mast cell T cell granulocyte leukocyte lymphocyte Other: Innate Immune System Signaling by WNT Platelet activation, signaling and aggregation Rnf43 Gene Information Basic Information Ensembl ID: ENSMUSG00000034177 Description: ring finger protein 43 [Source:MGI Symbol;Acc:MGI:2442609] Location: 11:87553548-87626365 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by WNT Rspo1 Gene Information Basic Information Ensembl ID: ENSMUSG00000028871 Description: R-spondin 1 [Source:MGI Symbol;Acc:MGI:2183426] Location: 4:124880223-124902892 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Signaling by WNT Rspo3 Gene Information Basic Information Ensembl ID: ENSMUSG00000019880 Description: R-spondin 3 [Source:MGI Symbol;Acc:MGI:1920030] Location: 10:29328412-29411863 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell Other: Signaling by WNT Ryk Gene Information Basic Information Ensembl ID: ENSMUSG00000032547 Description: receptor-like tyrosine kinase [Source:MGI Symbol;Acc:MGI:101766] Location: 9:102712116-102785504 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell Other: Signaling by WNT Smurf1 Gene Information Basic Information Ensembl ID: ENSMUSG00000038780 Description: SMAD specific E3 ubiquitin protein ligase 1 [Source:MGI Symbol;Acc:MGI:1923038] Location: 5:144813305-144902657 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Adaptive Immune System Signaling by WNT Signaling by Hedgehog Smurf2 Gene Information Basic Information Ensembl ID: ENSMUSG00000018363 Description: SMAD specific E3 ubiquitin protein ligase 2 [Source:MGI Symbol;Acc:MGI:1913563] Location: 11:106710892-106811541 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Adaptive Immune System Signaling by WNT Signaling by Hedgehog Sox4 Gene Information Basic Information Ensembl ID: ENSMUSG00000076431 Description: SRY (sex determining region Y)-box 4 [Source:MGI Symbol;Acc:MGI:98366] Location: 13:29132902-29137696 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: ionocyte Other: Signaling by WNT Sox9 Gene Information Basic Information Ensembl ID: ENSMUSG00000000567 Description: SRY (sex determining region Y)-box 9 [Source:MGI Symbol;Acc:MGI:98371] Location: 11:112673050-112678586 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell stromal cell tuft cell muscle cell chondrocyte bone cell progenitor cell hepatocyte natural killer cell stem cell Other: Signaling by WNT RNA Polymerase II Transcription Tcf7l2 Gene Information Basic Information Ensembl ID: ENSMUSG00000024985 Description: transcription factor 7 like 2%2C T cell specific%2C HMG box [Source:MGI Symbol;Acc:MGI:1202879] Location: 19:55730252-55922086 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell fibroblast macrophage excitatory neuron mesenchymal cell oligodendrocyte Other: Signaling by WNT RNA Polymerase II Transcription MITF-M-regulated melanocyte development Vps35 Gene Information Basic Information Ensembl ID: ENSMUSG00000031696 Description: VPS35 retromer complex component [Source:MGI Symbol;Acc:MGI:1890467] Location: 8:85987021-86026431 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by WNT Wls Gene Information Basic Information Ensembl ID: ENSMUSG00000028173 Description: wntless WNT ligand secretion mediator [Source:MGI Symbol;Acc:MGI:1915401] Location: 3:159545309-159644300 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell stem cell pneumocyte stromal cell retinal pigment epithelial cell Other: Signaling by WNT Wnt10a Gene Information Basic Information Ensembl ID: ENSMUSG00000026167 Description: wingless-type MMTV integration site family%2C member 10A [Source:MGI Symbol;Acc:MGI:108071] Location: 1:74830675-74843338 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stem cell Other: Signaling by WNT Wnt10b Gene Information Basic Information Ensembl ID: ENSMUSG00000022996 Description: wingless-type MMTV integration site family%2C member 10B [Source:MGI Symbol;Acc:MGI:108061] Location: 15:98668593-98676031 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: melanocyte Other: Signaling by WNT Wnt11 Gene Information Basic Information Ensembl ID: ENSMUSG00000015957 Description: wingless-type MMTV integration site family%2C member 11 [Source:MGI Symbol;Acc:MGI:101948] Location: 7:98484319-98504402 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by WNT Wnt2 Gene Information Basic Information Ensembl ID: ENSMUSG00000010797 Description: wingless-type MMTV integration site family%2C member 2 [Source:MGI Symbol;Acc:MGI:98954] Location: 6:17988939-18030584 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stem cell mesodermal cell Other: Signaling by WNT Wnt2b Gene Information Basic Information Ensembl ID: ENSMUSG00000027840 Description: wingless-type MMTV integration site family%2C member 2B [Source:MGI Symbol;Acc:MGI:1261834] Location: 3:104852588-104869237 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by WNT Wnt3 Gene Information Basic Information Ensembl ID: ENSMUSG00000000125 Description: wingless-type MMTV integration site family%2C member 3 [Source:MGI Symbol;Acc:MGI:98955] Location: 11:103664976-103708783 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: club cell Other: Signaling by WNT Wnt4 Gene Information Basic Information Ensembl ID: ENSMUSG00000036856 Description: wingless-type MMTV integration site family%2C member 4 [Source:MGI Symbol;Acc:MGI:98957] Location: 4:137004800-137027037 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell stem cell fibroblast theca cell Other: Signaling by WNT Wnt5a Gene Information Basic Information Ensembl ID: ENSMUSG00000021994 Description: wingless-type MMTV integration site family%2C member 5A [Source:MGI Symbol;Acc:MGI:98958] Location: 14:28226707-28249405 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: smooth muscle cell ectodermal cell epithelial cell Other: Membrane Trafficking Signaling by WNT Wnt5b Gene Information Basic Information Ensembl ID: ENSMUSG00000030170 Description: wingless-type MMTV integration site family%2C member 5B [Source:MGI Symbol;Acc:MGI:98959] Location: 6:119409492-119521308 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Signaling by WNT Wnt6 Gene Information Basic Information Ensembl ID: ENSMUSG00000033227 Description: wingless-type MMTV integration site family%2C member 6 [Source:MGI Symbol;Acc:MGI:98960] Location: 1:74811051-74824481 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell stem cell granulosa cell Other: Signaling by WNT Wnt7a Gene Information Basic Information Ensembl ID: ENSMUSG00000030093 Description: wingless-type MMTV integration site family%2C member 7A [Source:MGI Symbol;Acc:MGI:98961] Location: 6:91340963-91388345 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by WNT Wnt7b Gene Information Basic Information Ensembl ID: ENSMUSG00000022382 Description: wingless-type MMTV integration site family%2C member 7B [Source:MGI Symbol;Acc:MGI:98962] Location: 15:85419638-85466674 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: progenitor cell stem cell epithelial cell Other: Signaling by WNT Wnt8b Gene Information Basic Information Ensembl ID: ENSMUSG00000036961 Description: wingless-type MMTV integration site family%2C member 8B [Source:MGI Symbol;Acc:MGI:109485] Location: 19:44481911-44502712 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by WNT Wnt9a Gene Information Basic Information Ensembl ID: ENSMUSG00000000126 Description: wingless-type MMTV integration site family%2C member 9A [Source:MGI Symbol;Acc:MGI:2446084] Location: 11:59197754-59224378 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by WNT Wnt9b Gene Information Basic Information Ensembl ID: ENSMUSG00000018486 Description: wingless-type MMTV integration site family%2C member 9B [Source:MGI Symbol;Acc:MGI:1197020] Location: 11:103618190-103640647 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Signaling by WNT Znrf3 Gene Information Basic Information Ensembl ID: ENSMUSG00000041961 Description: zinc and ring finger 3 [Source:MGI Symbol;Acc:MGI:3039616] Location: 11:5226324-5394847 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell astrocyte Specialized T cell Other: Signaling by WNT
Smooth Muscle Contraction Pathway Hierarchies & Genes Smooth Muscle Contraction (4 genes) Muscle contraction Smooth Muscle Contraction 4 genes	Acta2 Gene Information Basic Information Ensembl ID: ENSMUSG00000035783 Description: actin alpha 2%2C smooth muscle%2C aorta [Source:MGI Symbol;Acc:MGI:87909] Location: 19:34218490-34232990 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte stellate cell endothelial cell stem cell smooth muscle cell fibroblast mural cell mesangial cell progenitor cell muscle cell mesenchymal cell Other: Non-integrin membrane-ECM interactions Smooth Muscle Contraction Cell junction organization Itga1 Gene Information Basic Information Ensembl ID: ENSMUSG00000042284 Description: integrin alpha 1 [Source:MGI Symbol;Acc:MGI:96599] Location: 13:115089632-115238500 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell pericyte stellate cell epithelial cell mural cell Other: Integrin cell surface interactions Smooth Muscle Contraction Pak1 Gene Information Basic Information Ensembl ID: ENSMUSG00000030774 Description: p21 (RAC1) activated kinase 1 [Source:MGI Symbol;Acc:MGI:1339975] Location: 7:97437748-97561588 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell epithelial cell excitatory neuron Other: Adaptive Immune System Innate Immune System Signaling by GPCR Tln1 Gene Information Basic Information Ensembl ID: ENSMUSG00000028465 Description: talin 1 [Source:MGI Symbol;Acc:MGI:1099832] Location: 4:43531519-43562691 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell phagocyte monocyte eosinophil megakaryocyte dendritic cell Other: Integrin signaling Smooth Muscle Contraction MAPK family signaling cascades
Surfactant metabolism Pathway Hierarchies & Genes Surfactant metabolism (9 genes) Metabolism of proteins Surfactant metabolism 9 genes	Adgrf5 Gene Information Basic Information Ensembl ID: ENSMUSG00000056492 Description: adhesion G protein-coupled receptor F5 [Source:MGI Symbol;Acc:MGI:2182928] Location: 17:43671342-43770448 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Surfactant metabolism Adora2a Gene Information Basic Information Ensembl ID: ENSMUSG00000020178 Description: adenosine A2a receptor [Source:MGI Symbol;Acc:MGI:99402] Location: 10:75152711-75170618 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by GPCR Surfactant metabolism Adra2a Gene Information Basic Information Ensembl ID: ENSMUSG00000033717 Description: adrenergic receptor%2C alpha 2a [Source:MGI Symbol;Acc:MGI:87934] Location: 19:54032582-54037413 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte retina cell mural cell Other: Integration of energy metabolism Signaling by GPCR Surfactant metabolism Adra2c Gene Information Basic Information Ensembl ID: ENSMUSG00000045318 Description: adrenergic receptor%2C alpha 2c [Source:MGI Symbol;Acc:MGI:87936] Location: 5:35435663-35439107 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Integration of energy metabolism Signaling by GPCR Surfactant metabolism Ckap4 Gene Information Basic Information Ensembl ID: ENSMUSG00000046841 Description: cytoskeleton-associated protein 4 [Source:MGI Symbol;Acc:MGI:2444926] Location: 10:84362169-84369926 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell fibroblast smooth muscle cell granulocyte epithelial cell osteoblast Other: Innate Immune System Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Surfactant metabolism Ctsh Gene Information Basic Information Ensembl ID: ENSMUSG00000032359 Description: cathepsin H [Source:MGI Symbol;Acc:MGI:107285] Location: 9:89936205-89958142 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte pneumocyte monocyte T cell myeloid progenitor cell Other: Adaptive Immune System Innate Immune System Surfactant metabolism Gata6 Gene Information Basic Information Ensembl ID: ENSMUSG00000005836 Description: GATA binding protein 6 [Source:MGI Symbol;Acc:MGI:107516] Location: 18:11052064-11085635 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast smooth muscle cell cardiomyocyte pancreatic cell endodermal cell epithelial cell Other: Surfactant metabolism Factors involved in megakaryocyte development and platelet production Napsa Gene Information Basic Information Ensembl ID: ENSMUSG00000002204 Description: napsin A aspartic peptidase [Source:MGI Symbol;Acc:MGI:109365] Location: 7:44221804-44236286 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell Naive B cell phagocyte pneumocyte monocyte Other: Surfactant metabolism P2ry2 Gene Information Basic Information Ensembl ID: ENSMUSG00000032860 Description: purinergic receptor P2Y%2C G-protein coupled 2 [Source:MGI Symbol;Acc:MGI:105107] Location: 7:100645775-100662073 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by GPCR Surfactant metabolism Cellular responses to mechanical stimuli
Translation Pathway Hierarchies & Genes Mitochondrial translation elongation (1 genes) Metabolism of proteins Translation Mitochondrial translation Mitochondrial translation elongation 1 genes	Gadd45gip1 Gene Information Basic Information Ensembl ID: ENSMUSG00000033751 Description: growth arrest and DNA-damage-inducible%2C gamma interacting protein 1 [Source:MGI Symbol;Acc:MGI:1914947] Location: 8:85558151-85562111 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Translation
Transmission across Chemical Synapses Pathway Hierarchies & Genes Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (2 genes) Neuronal System Transmission across Chemical Synapses Neurotransmitter receptors and postsynaptic signal transmission GABA receptor activation GABA B receptor activation Activation of GABAB receptors Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 2 genes Activation of Ca-permeable Kainate Receptor (3 genes) Neuronal System Transmission across Chemical Synapses Neurotransmitter receptors and postsynaptic signal transmission Activation of kainate receptors upon glutamate binding Ionotropic activity of kainate receptors Activation of Ca-permeable Kainate Receptor 3 genes Activation of GABAB receptors (3 genes) Neuronal System Transmission across Chemical Synapses Neurotransmitter receptors and postsynaptic signal transmission GABA receptor activation GABA B receptor activation Activation of GABAB receptors 3 genes CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling (1 genes) Neuronal System Transmission across Chemical Synapses Neurotransmitter receptors and postsynaptic signal transmission Activation of NMDA receptors and postsynaptic events Post NMDA receptor activation events CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 1 genes Trafficking of GluR2-containing AMPA receptors (3 genes) Neuronal System Transmission across Chemical Synapses Neurotransmitter receptors and postsynaptic signal transmission Glutamate binding, activation of AMPA receptors and synaptic plasticity Trafficking of AMPA receptors Trafficking of GluR2-containing AMPA receptors 3 genes Trafficking of AMPA receptors (1 genes) Neuronal System Transmission across Chemical Synapses Neurotransmitter receptors and postsynaptic signal transmission Glutamate binding, activation of AMPA receptors and synaptic plasticity Trafficking of AMPA receptors 1 genes Unblocking of NMDA receptors, glutamate binding and activation (1 genes) Neuronal System Transmission across Chemical Synapses Neurotransmitter receptors and postsynaptic signal transmission Activation of NMDA receptors and postsynaptic events Unblocking of NMDA receptors, glutamate binding and activation 1 genes Serotonin Neurotransmitter Release Cycle (1 genes) Neuronal System Transmission across Chemical Synapses Neurotransmitter release cycle Serotonin Neurotransmitter Release Cycle 1 genes	Akap5 Gene Information Basic Information Ensembl ID: ENSMUSG00000021057 Description: A kinase anchor protein 5 [Source:MGI Symbol;Acc:MGI:2685104] Location: 12:76371665-76380927 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell pneumocyte Other: Transmission across Chemical Synapses Creb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000025958 Description: cAMP responsive element binding protein 1 [Source:MGI Symbol;Acc:MGI:88494] Location: 1:64571804-64643707 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Transmission across Chemical Synapses Cytokine Signaling in Immune system Innate Immune System Dlg1 Gene Information Basic Information Ensembl ID: ENSMUSG00000022770 Description: discs large MAGUK scaffold protein 1 [Source:MGI Symbol;Acc:MGI:107231] Location: 16:31482261-31693947 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell ectodermal cell Other: Transmission across Chemical Synapses MAPK family signaling cascades Protein-protein interactions at synapses Dlg2 Gene Information Basic Information Ensembl ID: ENSMUSG00000052572 Description: discs large MAGUK scaffold protein 2 [Source:MGI Symbol;Acc:MGI:1344351] Location: 7:90125880-92098455 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron epithelial cell Other: Transmission across Chemical Synapses MAPK family signaling cascades Protein-protein interactions at synapses Dlg3 Gene Information Basic Information Ensembl ID: ENSMUSG00000000881 Description: discs large MAGUK scaffold protein 3 [Source:MGI Symbol;Acc:MGI:1888986] Location: X:99811328-99862016 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Transmission across Chemical Synapses MAPK family signaling cascades Protein-protein interactions at synapses Dlg4 Gene Information Basic Information Ensembl ID: ENSMUSG00000020886 Description: discs large MAGUK scaffold protein 4 [Source:MGI Symbol;Acc:MGI:1277959] Location: 11:69907768-69938348 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: photoreceptor cell Other: Transmission across Chemical Synapses LGI-ADAM interactions MAPK family signaling cascades Gabbr1 Gene Information Basic Information Ensembl ID: ENSMUSG00000024462 Description: gamma-aminobutyric acid type B receptor subunit 1 [Source:MGI Symbol;Acc:MGI:1860139] Location: 17:37356858-37385959 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Transmission across Chemical Synapses Potassium Channels Signaling by GPCR Gnai1 Gene Information Basic Information Ensembl ID: ENSMUSG00000057614 Description: G protein subunit alpha i1 [Source:MGI Symbol;Acc:MGI:95771] Location: 5:18470133-18565353 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: mast cell adipocyte Other: Transmission across Chemical Synapses Integration of energy metabolism Signaling by GPCR Gnai3 Gene Information Basic Information Ensembl ID: ENSMUSG00000000001 Description: G protein subunit alpha i3 [Source:MGI Symbol;Acc:MGI:95773] Location: 3:108014596-108053462 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Transmission across Chemical Synapses Signaling by GPCR Platelet activation, signaling and aggregation Gnal Gene Information Basic Information Ensembl ID: ENSMUSG00000024524 Description: guanine nucleotide binding protein%2C alpha stimulating%2C olfactory type [Source:MGI Symbol;Acc:MGI:95774] Location: 18:67221287-67359863 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: projection neuron Other: Transmission across Chemical Synapses Signaling by GPCR Olfactory Signaling Pathway Gngt2 Gene Information Basic Information Ensembl ID: ENSMUSG00000038811 Description: guanine nucleotide binding protein (G protein)%2C gamma transducing activity polypeptide 2 [Source:MGI Symbol;Acc:MGI:893584] Location: 11:95728042-95736560 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell dendritic cell phagocyte monocyte myeloid cell plasma cell macrophage photoreceptor cell Other: Platelet homeostasis Transmission across Chemical Synapses Potassium Channels Gria1 Gene Information Basic Information Ensembl ID: ENSMUSG00000020524 Description: glutamate receptor%2C ionotropic%2C AMPA1 (alpha 1) [Source:MGI Symbol;Acc:MGI:95808] Location: 11:56902213-57221070 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: bergmann glial cell neuron Other: Transmission across Chemical Synapses Membrane Trafficking Post-translational protein modification Nsf Gene Information Basic Information Ensembl ID: ENSMUSG00000034187 Description: N-ethylmaleimide sensitive fusion protein [Source:MGI Symbol;Acc:MGI:104560] Location: 11:103712608-103844882 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron epithelial cell Naive B cell Other: Transmission across Chemical Synapses Membrane Trafficking Post-translational protein modification Pick1 Gene Information Basic Information Ensembl ID: ENSMUSG00000068206 Description: protein interacting with C kinase 1 [Source:MGI Symbol;Acc:MGI:894645] Location: 15:79113373-79133684 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Transmission across Chemical Synapses Slc18a2 Gene Information Basic Information Ensembl ID: ENSMUSG00000025094 Description: solute carrier family 18 (vesicular monoamine)%2C member 2 [Source:MGI Symbol;Acc:MGI:106677] Location: 19:59249328-59284444 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: mast cell modulatory neuron neuron Other: Transmission across Chemical Synapses SLC-mediated transmembrane transport
Visual phototransduction Pathway Hierarchies & Genes Activation of the phototransduction cascade (1 genes) Sensory Perception Visual phototransduction The phototransduction cascade Activation of the phototransduction cascade 1 genes Inactivation, recovery and regulation of the phototransduction cascade (1 genes) Sensory Perception Visual phototransduction The phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade 1 genes Retinoid metabolism and transport (3 genes) Sensory Perception Visual phototransduction The canonical retinoid cycle in rods (twilight vision) 2 genes Retinoid metabolism and transport 1 genes Retinoid metabolism and transport (4 genes) Sensory Perception Visual phototransduction Retinoid metabolism and transport 4 genes	Gnat1 Gene Information Basic Information Ensembl ID: ENSMUSG00000034837 Description: G protein subunit alpha transducin 1 [Source:MGI Symbol;Acc:MGI:95778] Location: 9:107551673-107556911 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: photoreceptor cell Other: Visual phototransduction Signaling by GPCR Gpc1 Gene Information Basic Information Ensembl ID: ENSMUSG00000034220 Description: glypican 1 [Source:MGI Symbol;Acc:MGI:1194891] Location: 1:92759367-92788501 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: glial cell podocyte Other: Metabolism of vitamins and cofactors Cell surface interactions at the vascular wall Visual phototransduction Gpc3 Gene Information Basic Information Ensembl ID: ENSMUSG00000055653 Description: glypican 3 [Source:MGI Symbol;Acc:MGI:104903] Location: X:51361303-51702827 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell stromal cell embryonic cell fibroblast epithelial cell Other: Metabolism of vitamins and cofactors Visual phototransduction Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Lpl Gene Information Basic Information Ensembl ID: ENSMUSG00000015568 Description: lipoprotein lipase [Source:MGI Symbol;Acc:MGI:96820] Location: 8:69333143-69360100 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: preadipocyte phagocyte fibroblast epithelial cell stromal cell erythrocyte dendritic cell macrophage endothelial cell antigen presenting cell adipocyte Other: Plasma lipoprotein assembly, remodeling, and clearance Metabolism of vitamins and cofactors Visual phototransduction Rbp1 Gene Information Basic Information Ensembl ID: ENSMUSG00000046402 Description: retinol binding protein 1%2C cellular [Source:MGI Symbol;Acc:MGI:97876] Location: 9:98305014-98328628 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell fibroblast stellate cell stem cell glial cell epithelial cell Other: Metabolism of vitamins and cofactors Visual phototransduction Rdh10 Gene Information Basic Information Ensembl ID: ENSMUSG00000025921 Description: retinol dehydrogenase 10 (all-trans) [Source:MGI Symbol;Acc:MGI:1924238] Location: 1:16175998-16203958 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell epithelial cell retinal pigment epithelial cell Other: Visual phototransduction Signaling by Nuclear Receptors Sag Gene Information Basic Information Ensembl ID: ENSMUSG00000056055 Description: S-antigen%2C retina and pineal gland (arrestin) [Source:MGI Symbol;Acc:MGI:98227] Location: 1:87731402-87772880 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endocrine cell photoreceptor cell Other: Visual phototransduction Sdc2 Gene Information Basic Information Ensembl ID: ENSMUSG00000022261 Description: syndecan 2 [Source:MGI Symbol;Acc:MGI:1349165] Location: 15:32920869-33035081 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte osteoblast mural cell Other: Metabolism of vitamins and cofactors Cell surface interactions at the vascular wall Visual phototransduction Sdr9c7 Gene Information Basic Information Ensembl ID: ENSMUSG00000040127 Description: 4short chain dehydrogenase/reductase family 9C%2C member 7 [Source:MGI Symbol;Acc:MGI:1917311] Location: 10:127734387-127747630 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Visual phototransduction
mRNA Editing Pathway Hierarchies & Genes Formation of the Editosome (1 genes) Metabolism of RNA mRNA Editing mRNA Editing: C to U Conversion Formation of the Editosome 1 genes	Apobec1 Gene Information Basic Information Ensembl ID: ENSMUSG00000040613 Description: apolipoprotein B mRNA editing enzyme%2C catalytic polypeptide 1 [Source:MGI Symbol;Acc:MGI:103298] Location: 6:122554751-122579403 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte monocyte macrophage Other: mRNA Editing

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