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Name

Mouse General

#1100

Species

Mus musculus

# Genes

400

# Serial Genes

Description

Maps cell types and biological pathways across multiple mouse tissues.

Genes & Annotations

Reactome is a database of signaling and metabolic molecules organized into heirarchical pathways and relationships. Here we show the high level pathways, except 'Disease'. You can click on the pathway to see the full heirarchy and which levels are impacted by genes in the panel.

Annotation	Genes
Adaptive Immune System Pathway Hierarchies & Genes Co-inhibition by PD-1 (17 genes) Immune System Adaptive Immune System Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 13 genes TCR signaling Downstream TCR signaling 2 genes Regulation of T cell activation by CD28 family Co-inhibition by PD-1 2 genes Co-inhibition by PD-1 (1 genes) Immune System Adaptive Immune System TCR signaling Downstream TCR signaling Regulation of T cell activation by CD28 family Co-inhibition by PD-1 1 genes Activation of NF-kappaB in B cells (1 genes) Immune System Adaptive Immune System Signaling by the B Cell Receptor (BCR) Downstream signaling events of B Cell Receptor (BCR) Activation of NF-kappaB in B cells 1 genes CD28 dependent PI3K/Akt signaling (3 genes) Immune System Adaptive Immune System Regulation of T cell activation by CD28 family Co-stimulation by CD28 CD28 dependent PI3K/Akt signaling 3 genes Cross-presentation of particulate exogenous antigens (phagosomes) (3 genes) Immune System Adaptive Immune System Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Cross-presentation of particulate exogenous antigens (phagosomes) 3 genes Cross-presentation of soluble exogenous antigens (endosomes) (2 genes) Immune System Adaptive Immune System Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Cross-presentation of soluble exogenous antigens (endosomes) 2 genes ER-Phagosome pathway (1 genes) Immune System Adaptive Immune System Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation ER-Phagosome pathway 1 genes Antigen processing: Ubiquitination & Proteasome degradation (1 genes) Immune System Adaptive Immune System Class I MHC mediated antigen processing & presentation Antigen processing: Ubiquitination & Proteasome degradation 1 genes CD22 mediated BCR regulation (1 genes) Immune System Adaptive Immune System Signaling by the B Cell Receptor (BCR) CD22 mediated BCR regulation 1 genes Co-inhibition by PD-1 (2 genes) Immune System Adaptive Immune System Regulation of T cell activation by CD28 family Co-inhibition by PD-1 2 genes Co-stimulation by CD28 (1 genes) Immune System Adaptive Immune System Regulation of T cell activation by CD28 family Co-stimulation by CD28 1 genes MHC class II antigen presentation (3 genes) Immune System Adaptive Immune System MHC class II antigen presentation 3 genes	Asb9 Gene Information Basic Information Ensembl ID: ENSMUSG00000031384 Description: ankyrin repeat and SOCS box-containing 9 [Source:MGI Symbol;Acc:MGI:1916549] Location: X:163289323-163322748 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Adaptive Immune System Post-translational protein modification Cd19 Gene Information Basic Information Ensembl ID: ENSMUSG00000030724 Description: CD19 antigen [Source:MGI Symbol;Acc:MGI:88319] Location: 7:126007622-126014061 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Naive B cell Follicular B cell memory B cell Other: Adaptive Immune System Innate Immune System Intracellular signaling by second messengers Cd22 Gene Information Basic Information Ensembl ID: ENSMUSG00000030577 Description: CD22 antigen [Source:MGI Symbol;Acc:MGI:88322] Location: 7:30564827-30579767 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Naive B cell Follicular B cell Other: Adaptive Immune System Cd28 Gene Information Basic Information Ensembl ID: ENSMUSG00000026012 Description: CD28 antigen [Source:MGI Symbol;Acc:MGI:88327] Location: 1:60755959-60812518 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell Regulatory T cell CD4+ T cell Specialized T cell T cell Other: Adaptive Immune System Intracellular signaling by second messengers Cd34 Gene Information Basic Information Ensembl ID: ENSMUSG00000016494 Description: CD34 antigen [Source:MGI Symbol;Acc:MGI:88329] Location: 1:194621127-194643587 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast endothelial cell stem cell hematopoietic stem cell eosinophil Other: Adaptive Immune System Cd36 Gene Information Basic Information Ensembl ID: ENSMUSG00000002944 Description: CD36 molecule [Source:MGI Symbol;Acc:MGI:107899] Location: 5:17986688-18093799 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: macrophage Other: Adaptive Immune System Integration of energy metabolism Innate Immune System Cd3d Gene Information Basic Information Ensembl ID: ENSMUSG00000032094 Description: CD3 antigen%2C delta polypeptide [Source:MGI Symbol;Acc:MGI:88331] Location: 9:44893084-44898637 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell CD8+ T cell developing T cell Specialized T cell Other: Adaptive Immune System Membrane Trafficking Cd3e Gene Information Basic Information Ensembl ID: ENSMUSG00000032093 Description: CD3 antigen%2C epsilon polypeptide [Source:MGI Symbol;Acc:MGI:88332] Location: 9:44910038-44920925 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell developing T cell lymphocyte CD4+ T cell CD8+ T cell neutrophil T cell Specialized T cell T helper cell Naive B cell Regulatory T cell Other: Adaptive Immune System Cd4 Gene Information Basic Information Ensembl ID: ENSMUSG00000023274 Description: CD4 antigen [Source:MGI Symbol;Acc:MGI:88335] Location: 6:124841655-124865184 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell Regulatory T cell CD4+ T cell dendritic cell T cell Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Cd40 Gene Information Basic Information Ensembl ID: ENSMUSG00000017652 Description: CD40 antigen [Source:MGI Symbol;Acc:MGI:88336] Location: 2:164897547-164914868 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell Other: Cytokine Signaling in Immune system Adaptive Immune System Cd40lg Gene Information Basic Information Ensembl ID: ENSMUSG00000031132 Description: CD40 ligand [Source:MGI Symbol;Acc:MGI:88337] Location: X:56257503-56269402 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: CD4+ T cell Other: Cytokine Signaling in Immune system Adaptive Immune System Cd79a Gene Information Basic Information Ensembl ID: ENSMUSG00000003379 Description: CD79A antigen (immunoglobulin-associated alpha) [Source:MGI Symbol;Acc:MGI:101774] Location: 7:24596806-24601622 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Naive B cell innate lymphoid cell Other: Adaptive Immune System Cd80 Gene Information Basic Information Ensembl ID: ENSMUSG00000075122 Description: CD80 antigen [Source:MGI Symbol;Acc:MGI:101775] Location: 16:38275923-38316697 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Adaptive Immune System Intracellular signaling by second messengers Cd86 Gene Information Basic Information Ensembl ID: ENSMUSG00000022901 Description: CD86 antigen [Source:MGI Symbol;Acc:MGI:101773] Location: 16:36424231-36486443 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell Naive B cell phagocyte leukocyte Other: Adaptive Immune System Intracellular signaling by second messengers Cd8a Gene Information Basic Information Ensembl ID: ENSMUSG00000053977 Description: CD8 subunit alpha [Source:MGI Symbol;Acc:MGI:88346] Location: 6:71350411-71356157 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell CD8+ T cell Other: Adaptive Immune System Cd96 Gene Information Basic Information Ensembl ID: ENSMUSG00000022657 Description: CD96 antigen [Source:MGI Symbol;Acc:MGI:1934368] Location: 16:45856020-45940614 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell Specialized T cell Other: Adaptive Immune System Col17a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000025064 Description: collagen%2C type XVII%2C alpha 1 [Source:MGI Symbol;Acc:MGI:88450] Location: 19:47634783-47680533 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stem cell epithelial cell Other: Adaptive Immune System Collagen formation Cell junction organization Ctla4 Gene Information Basic Information Ensembl ID: ENSMUSG00000026011 Description: cytotoxic T-lymphocyte-associated protein 4 [Source:MGI Symbol;Acc:MGI:88556] Location: 1:60926159-60954991 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell Regulatory T cell CD4+ T cell cajal-retzius cell Other: Adaptive Immune System Ctse Gene Information Basic Information Ensembl ID: ENSMUSG00000004552 Description: cathepsin E [Source:MGI Symbol;Acc:MGI:107361] Location: 1:131566044-131603243 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell hematopoietic progenitor cell granulocyte Other: Adaptive Immune System Cybb Gene Information Basic Information Ensembl ID: ENSMUSG00000015340 Description: cytochrome b-245%2C beta polypeptide [Source:MGI Symbol;Acc:MGI:88574] Location: X:9301491-9354010 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: monocyte Other: Adaptive Immune System Innate Immune System Cellular responses to stress Fcgr1 Gene Information Basic Information Ensembl ID: ENSMUSG00000015947 Description: Fc receptor%2C IgG%2C high affinity I [Source:MGI Symbol;Acc:MGI:95498] Location: 3:96190225-96201285 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte antigen presenting cell macrophage dendritic cell monocyte hematopoietic cell neutrophil Other: Adaptive Immune System Innate Immune System Icam1 Gene Information Basic Information Ensembl ID: ENSMUSG00000037405 Description: intercellular adhesion molecule 1 [Source:MGI Symbol;Acc:MGI:96392] Location: 9:20927281-20940113 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stem cell pneumocyte Other: Adaptive Immune System Integrin cell surface interactions Itgal Gene Information Basic Information Ensembl ID: ENSMUSG00000030830 Description: integrin alpha L [Source:MGI Symbol;Acc:MGI:96606] Location: 7:126895432-126934310 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell CD4+ T cell CD8+ T cell monocyte Specialized T cell Other: Adaptive Immune System Innate Immune System Cell surface interactions at the vascular wall Itgb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000025809 Description: integrin beta 1 (fibronectin receptor beta) [Source:MGI Symbol;Acc:MGI:96610] Location: 8:129412135-129459681 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell pericyte stellate cell stromal cell smooth muscle cell fibroblast muscle cell mural cell basal cell kidney cell Other: Laminin interactions Adaptive Immune System Elastic fibre formation Klrk1 Gene Information Basic Information Ensembl ID: ENSMUSG00000030149 Description: killer cell lectin-like receptor subfamily K%2C member 1 [Source:MGI Symbol;Acc:MGI:1196250] Location: 6:129587286-129600827 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell developing T cell Other: Adaptive Immune System Innate Immune System Lag3 Gene Information Basic Information Ensembl ID: ENSMUSG00000030124 Description: lymphocyte-activation gene 3 [Source:MGI Symbol;Acc:MGI:106588] Location: 6:124881324-124888668 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell Regulatory T cell CD8+ T cell myeloid progenitor cell Other: Adaptive Immune System Mrc1 Gene Information Basic Information Ensembl ID: ENSMUSG00000026712 Description: mannose receptor%2C C type 1 [Source:MGI Symbol;Acc:MGI:97142] Location: 2:14234203-14336868 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell phagocyte dendritic cell antigen presenting cell T cell myeloid derived suppressor cell macrophage pericyte Other: Adaptive Immune System Ncf4 Gene Information Basic Information Ensembl ID: ENSMUSG00000071715 Description: neutrophil cytosolic factor 4 [Source:MGI Symbol;Acc:MGI:109186] Location: 15:78129001-78146780 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell dendritic cell erythrocyte granulocyte monocyte Other: Adaptive Immune System Innate Immune System Cellular responses to stress Nectin2 Gene Information Basic Information Ensembl ID: ENSMUSG00000062300 Description: nectin cell adhesion molecule 2 [Source:MGI Symbol;Acc:MGI:97822] Location: 7:19450569-19484408 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell epithelial cell Other: Adaptive Immune System Cell junction organization Pdcd1 Gene Information Basic Information Ensembl ID: ENSMUSG00000026285 Description: programmed cell death 1 [Source:MGI Symbol;Acc:MGI:104879] Location: 1:93966027-93980278 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell CD4+ T cell CD8+ T cell T helper cell developing T cell lymphocyte T cell Other: Adaptive Immune System Pdcd1lg2 Gene Information Basic Information Ensembl ID: ENSMUSG00000016498 Description: programmed cell death 1 ligand 2 [Source:MGI Symbol;Acc:MGI:1930125] Location: 19:29388319-29448561 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: memory B cell Other: Adaptive Immune System Psmb8 Gene Information Basic Information Ensembl ID: ENSMUSG00000024338 Description: proteasome (prosome%2C macropain) subunit%2C beta type 8 (large multifunctional peptidase 7) [Source:MGI Symbol;Acc:MGI:1346527] Location: 17:34416695-34420428 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell dendritic cell developing T cell Regulatory T cell Naive B cell monocyte endothelial cell CD8+ T cell macrophage lymphocyte T cell Other: Adaptive Immune System Post-translational protein modification Rel Gene Information Basic Information Ensembl ID: ENSMUSG00000020275 Description: reticuloendotheliosis oncogene [Source:MGI Symbol;Acc:MGI:97897] Location: 11:23686847-23720970 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell Naive B cell phagocyte T cell Other: Adaptive Immune System Sell Gene Information Basic Information Ensembl ID: ENSMUSG00000026581 Description: selectin%2C lymphocyte [Source:MGI Symbol;Acc:MGI:98279] Location: 1:163889551-163911750 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell natural killer cell Regulatory T cell Naive B cell Specialized T cell CD8+ T cell dendritic cell T cell myeloid progenitor cell CD4+ T cell developing T cell Other: Adaptive Immune System Innate Immune System Cell surface interactions at the vascular wall Slamf7 Gene Information Basic Information Ensembl ID: ENSMUSG00000038179 Description: SLAM family member 7 [Source:MGI Symbol;Acc:MGI:1922595] Location: 1:171459971-171480603 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell phagocyte Naive B cell dendritic cell plasma cell Other: Adaptive Immune System Tubb3 Gene Information Basic Information Ensembl ID: ENSMUSG00000062380 Description: tubulin%2C beta 3 class III [Source:MGI Symbol;Acc:MGI:107813] Location: 8:124138163-124148754 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell neuron motor neuron Other: Cytokine Signaling in Immune system Adaptive Immune System Macroautophagy
Apoptosis Pathway Hierarchies & Genes Regulation by c-FLIP (2 genes) Programmed Cell Death Apoptosis Caspase activation via extrinsic apoptotic signalling pathway Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP 2 genes Apoptotic cleavage of cellular proteins (1 genes) Programmed Cell Death Apoptosis Apoptotic execution phase Apoptotic cleavage of cellular proteins 1 genes Caspase activation via Death Receptors in the presence of ligand (2 genes) Programmed Cell Death Apoptosis Caspase activation via extrinsic apoptotic signalling pathway Caspase activation via Death Receptors in the presence of ligand 2 genes	Cd14 Gene Information Basic Information Ensembl ID: ENSMUSG00000051439 Description: CD14 antigen [Source:MGI Symbol;Acc:MGI:88318] Location: 18:36858120-36859851 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell dendritic cell phagocyte monocyte microglia granulocyte myeloid cell T cell leukocyte neutrophil macrophage Other: Apoptosis Innate Immune System Fas Gene Information Basic Information Ensembl ID: ENSMUSG00000024778 Description: Fas cell surface death receptor [Source:MGI Symbol;Acc:MGI:95484] Location: 19:34268066-34305172 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell smooth muscle cell Other: Apoptosis Regulated Necrosis Death Receptor Signaling Fasl Gene Information Basic Information Ensembl ID: ENSMUSG00000000817 Description: Fas ligand [Source:MGI Symbol;Acc:MGI:99255] Location: 1:161608258-161616064 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell CD8+ T cell T cell Other: Apoptosis Regulated Necrosis Death Receptor Signaling Satb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000023927 Description: special AT-rich sequence binding protein 1 [Source:MGI Symbol;Acc:MGI:105084] Location: 17:52043215-52140318 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell developing T cell excitatory neuron Specialized T cell innate lymphoid cell lymphocyte Other: Apoptosis Post-translational protein modification Tlr4 Gene Information Basic Information Ensembl ID: ENSMUSG00000039005 Description: toll-like receptor 4 [Source:MGI Symbol;Acc:MGI:96824] Location: 4:66745821-66848521 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte Other: Apoptosis Innate Immune System Cellular responses to stress
Aquaporin-mediated transport Pathway Hierarchies & Genes Passive transport by Aquaporins (2 genes) Transport of small molecules Aquaporin-mediated transport Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins 2 genes Passive transport by Aquaporins (1 genes) Transport of small molecules Aquaporin-mediated transport Transport of glycerol from adipocytes to the liver by Aquaporins Passive transport by Aquaporins 1 genes Passive transport by Aquaporins (1 genes) Transport of small molecules Aquaporin-mediated transport Passive transport by Aquaporins 1 genes	Aqp3 Gene Information Basic Information Ensembl ID: ENSMUSG00000028435 Description: aquaporin 3 [Source:MGI Symbol;Acc:MGI:1333777] Location: 4:41092722-41098183 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stem cell epithelial cell basal cell Other: Aquaporin-mediated transport Aqp4 Gene Information Basic Information Ensembl ID: ENSMUSG00000024411 Description: aquaporin 4 [Source:MGI Symbol;Acc:MGI:107387] Location: 18:15522553-15544039 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell stem cell glial cell astrocyte Other: Aquaporin-mediated transport Aqp5 Gene Information Basic Information Ensembl ID: ENSMUSG00000044217 Description: aquaporin 5 [Source:MGI Symbol;Acc:MGI:106215] Location: 15:99488663-99492710 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Aquaporin-mediated transport Aqp7 Gene Information Basic Information Ensembl ID: ENSMUSG00000028427 Description: aquaporin 7 [Source:MGI Symbol;Acc:MGI:1314647] Location: 4:41033074-41048139 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Aquaporin-mediated transport
Binding and Uptake of Ligands by Scavenger Receptors Pathway Hierarchies & Genes Scavenging by Class A Receptors (1 genes) Vesicle-mediated transport Binding and Uptake of Ligands by Scavenger Receptors Scavenging by Class A Receptors 1 genes Scavenging by Class B Receptors (1 genes) Vesicle-mediated transport Binding and Uptake of Ligands by Scavenger Receptors Scavenging by Class B Receptors 1 genes Scavenging of heme from plasma (2 genes) Vesicle-mediated transport Binding and Uptake of Ligands by Scavenger Receptors Scavenging of heme from plasma 2 genes	Ambp Gene Information Basic Information Ensembl ID: ENSMUSG00000028356 Description: alpha 1 microglobulin/bikunin precursor [Source:MGI Symbol;Acc:MGI:88002] Location: 4:63061512-63073036 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endocrine cell pancreatic cell epithelial cell Other: Binding and Uptake of Ligands by Scavenger Receptors Cd163 Gene Information Basic Information Ensembl ID: ENSMUSG00000008845 Description: CD163 antigen [Source:MGI Symbol;Acc:MGI:2135946] Location: 6:124281615-124307486 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte antigen presenting cell T cell macrophage Other: Binding and Uptake of Ligands by Scavenger Receptors Cd36 Gene Information Basic Information Ensembl ID: ENSMUSG00000002944 Description: CD36 molecule [Source:MGI Symbol;Acc:MGI:107899] Location: 5:17986688-18093799 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: macrophage Other: Adaptive Immune System Integration of energy metabolism Innate Immune System Marco Gene Information Basic Information Ensembl ID: ENSMUSG00000026390 Description: macrophage receptor with collagenous structure [Source:MGI Symbol;Acc:MGI:1309998] Location: 1:120402267-120432753 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: antigen presenting cell Other: Binding and Uptake of Ligands by Scavenger Receptors
Biological oxidations Pathway Hierarchies & Genes Endogenous sterols (1 genes) Metabolism Biological oxidations Phase I - Functionalization of compounds Cytochrome P450 - arranged by substrate type Endogenous sterols 1 genes Glutathione synthesis and recycling (1 genes) Metabolism Biological oxidations Phase II - Conjugation of compounds Glutathione conjugation Glutathione synthesis and recycling 1 genes Ethanol oxidation (1 genes) Metabolism Biological oxidations Phase I - Functionalization of compounds Ethanol oxidation 1 genes	Aldh1b1 Gene Information Basic Information Ensembl ID: ENSMUSG00000035561 Description: aldehyde dehydrogenase 1 family%2C member B1 [Source:MGI Symbol;Acc:MGI:1919785] Location: 4:45799022-45804604 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Biological oxidations Mitochondrial protein degradation Cndp2 Gene Information Basic Information Ensembl ID: ENSMUSG00000024644 Description: CNDP dipeptidase 2 [Source:MGI Symbol;Acc:MGI:1913304] Location: 18:84685590-84703827 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell phagocyte antigen presenting cell monocyte macrophage Other: Biological oxidations Paracetamol ADME Cyp11a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000032323 Description: cytochrome P450%2C family 11%2C subfamily a%2C polypeptide 1 [Source:MGI Symbol;Acc:MGI:88582] Location: 9:57913694-57934306 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Biological oxidations Metabolism of lipids
Cardiac conduction Pathway Hierarchies & Genes Ion homeostasis (3 genes) Muscle contraction Cardiac conduction Ion homeostasis 3 genes	Fxyd6 Gene Information Basic Information Ensembl ID: ENSMUSG00000066705 Description: FXYD domain-containing ion transport regulator 6 [Source:MGI Symbol;Acc:MGI:1890226] Location: 9:45281483-45307457 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell interneuron glial cell enteroendocrine cell dendritic cell Other: Cardiac conduction Ion channel transport Pln Gene Information Basic Information Ensembl ID: ENSMUSG00000038583 Description: phospholamban [Source:MGI Symbol;Acc:MGI:97622] Location: 10:53213763-53222083 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: cardiomyocyte smooth muscle cell Other: Cardiac conduction Ion channel transport Trdn Gene Information Basic Information Ensembl ID: ENSMUSG00000019787 Description: triadin [Source:MGI Symbol;Acc:MGI:1924007] Location: 10:32956550-33352705 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: cardiomyocyte skeletal muscle cell fibroblast Other: Cardiac conduction Ion channel transport
Cell Cycle Checkpoints Pathway Hierarchies & Genes Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (1 genes) Cell Cycle Cell Cycle Checkpoints Mitotic Spindle Checkpoint Amplification of signal from the kinetochores Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 1 genes	Cenpf Gene Information Basic Information Ensembl ID: ENSMUSG00000026605 Description: centromere protein F [Source:MGI Symbol;Acc:MGI:1313302] Location: 1:189372803-189420283 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stromal cell neuron progenitor cell granulocyte Other: Cell Cycle, Mitotic Cell Cycle Checkpoints Signaling by Rho GTPases, Miro GTPases and RHOBTB3
Cell Cycle, Mitotic Pathway Hierarchies & Genes The role of GTSE1 in G2/M progression after G2 checkpoint (1 genes) Cell Cycle Cell Cycle, Mitotic M Phase Mitotic Metaphase and Anaphase Mitotic Anaphase Nuclear Envelope (NE) Reassembly Sealing of the nuclear envelope (NE) by ESCRT-III Mitotic G2-G2/M phases G2/M Transition The role of GTSE1 in G2/M progression after G2 checkpoint 1 genes Separation of Sister Chromatids (1 genes) Cell Cycle Cell Cycle, Mitotic M Phase Mitotic Metaphase and Anaphase Mitotic Anaphase Separation of Sister Chromatids 1 genes	Cenpf Gene Information Basic Information Ensembl ID: ENSMUSG00000026605 Description: centromere protein F [Source:MGI Symbol;Acc:MGI:1313302] Location: 1:189372803-189420283 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stromal cell neuron progenitor cell granulocyte Other: Cell Cycle, Mitotic Cell Cycle Checkpoints Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Tubb3 Gene Information Basic Information Ensembl ID: ENSMUSG00000062380 Description: tubulin%2C beta 3 class III [Source:MGI Symbol;Acc:MGI:107813] Location: 8:124138163-124148754 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell neuron motor neuron Other: Cytokine Signaling in Immune system Adaptive Immune System Macroautophagy
Cell junction organization Pathway Hierarchies & Genes Nectin/Necl trans heterodimerization (1 genes) Cell-Cell communication Cell junction organization Cell-cell junction organization Adherens junctions interactions Nectin/Necl trans heterodimerization 1 genes Localization of the PINCH-ILK-PARVIN complex to focal adhesions (1 genes) Cell-Cell communication Cell junction organization Cell-extracellular matrix interactions Localization of the PINCH-ILK-PARVIN complex to focal adhesions 1 genes Type I hemidesmosome assembly (2 genes) Cell-Cell communication Cell junction organization Type I hemidesmosome assembly 2 genes	Col17a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000025064 Description: collagen%2C type XVII%2C alpha 1 [Source:MGI Symbol;Acc:MGI:88450] Location: 19:47634783-47680533 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stem cell epithelial cell Other: Adaptive Immune System Collagen formation Cell junction organization Itga6 Gene Information Basic Information Ensembl ID: ENSMUSG00000027111 Description: integrin alpha 6 [Source:MGI Symbol;Acc:MGI:96605] Location: 2:71575960-71688760 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell epithelial cell progenitor cell Other: Cell surface interactions at the vascular wall Integrin cell surface interactions Laminin interactions Itgb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000025809 Description: integrin beta 1 (fibronectin receptor beta) [Source:MGI Symbol;Acc:MGI:96610] Location: 8:129412135-129459681 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell pericyte stellate cell stromal cell smooth muscle cell fibroblast muscle cell mural cell basal cell kidney cell Other: Laminin interactions Adaptive Immune System Elastic fibre formation Nectin2 Gene Information Basic Information Ensembl ID: ENSMUSG00000062300 Description: nectin cell adhesion molecule 2 [Source:MGI Symbol;Acc:MGI:97822] Location: 7:19450569-19484408 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell epithelial cell Other: Adaptive Immune System Cell junction organization
Cell surface interactions at the vascular wall Pathway Hierarchies & Genes Basigin interactions (19 genes) Hemostasis Cell surface interactions at the vascular wall 12 genes Basigin interactions 7 genes	Angpt2 Gene Information Basic Information Ensembl ID: ENSMUSG00000031465 Description: angiopoietin 2 [Source:MGI Symbol;Acc:MGI:1202890] Location: 8:18740279-18791578 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: retina cell endothelial cell dendritic cell Other: Cell surface interactions at the vascular wall Cav1 Gene Information Basic Information Ensembl ID: ENSMUSG00000007655 Description: caveolin 1%2C caveolae protein [Source:MGI Symbol;Acc:MGI:102709] Location: 6:17306334-17341451 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by WNT Metabolism of nitric oxide: NOS3 activation and regulation Cell surface interactions at the vascular wall Cd44 Gene Information Basic Information Ensembl ID: ENSMUSG00000005087 Description: CD44 antigen [Source:MGI Symbol;Acc:MGI:88338] Location: 2:102641486-102732010 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell phagocyte monocyte granulocyte neutrophil macrophage progenitor cell Other: Cell surface interactions at the vascular wall Integrin cell surface interactions Innate Immune System Cd48 Gene Information Basic Information Ensembl ID: ENSMUSG00000015355 Description: CD48 antigen [Source:MGI Symbol;Acc:MGI:88339] Location: 1:171509577-171532826 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell developing T cell monocyte CD8+ T cell Other: Cell surface interactions at the vascular wall Cd84 Gene Information Basic Information Ensembl ID: ENSMUSG00000038147 Description: CD84 antigen [Source:MGI Symbol;Acc:MGI:1336885] Location: 1:171667265-171718285 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte leukocyte basophil macrophage Other: Cell surface interactions at the vascular wall Epcam Gene Information Basic Information Ensembl ID: ENSMUSG00000045394 Description: epithelial cell adhesion molecule [Source:MGI Symbol;Acc:MGI:106653] Location: 17:87943407-87958557 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell stem cell enteroendocrine cell Other: Cell surface interactions at the vascular wall Itga6 Gene Information Basic Information Ensembl ID: ENSMUSG00000027111 Description: integrin alpha 6 [Source:MGI Symbol;Acc:MGI:96605] Location: 2:71575960-71688760 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell epithelial cell progenitor cell Other: Cell surface interactions at the vascular wall Integrin cell surface interactions Laminin interactions Itgal Gene Information Basic Information Ensembl ID: ENSMUSG00000030830 Description: integrin alpha L [Source:MGI Symbol;Acc:MGI:96606] Location: 7:126895432-126934310 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell CD4+ T cell CD8+ T cell monocyte Specialized T cell Other: Adaptive Immune System Innate Immune System Cell surface interactions at the vascular wall Itgam Gene Information Basic Information Ensembl ID: ENSMUSG00000030786 Description: integrin alpha M [Source:MGI Symbol;Acc:MGI:96607] Location: 7:127661812-127717663 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell phagocyte macrophage monocyte myeloid cell dendritic cell microglia myeloid derived suppressor cell immune cell Other: Innate Immune System Cell surface interactions at the vascular wall Integrin cell surface interactions Itgax Gene Information Basic Information Ensembl ID: ENSMUSG00000030789 Description: integrin alpha X [Source:MGI Symbol;Acc:MGI:96609] Location: 7:127728719-127749829 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell phagocyte macrophage dendritic cell Other: Innate Immune System Cell surface interactions at the vascular wall Integrin cell surface interactions Itgb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000025809 Description: integrin beta 1 (fibronectin receptor beta) [Source:MGI Symbol;Acc:MGI:96610] Location: 8:129412135-129459681 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell pericyte stellate cell stromal cell smooth muscle cell fibroblast muscle cell mural cell basal cell kidney cell Other: Laminin interactions Adaptive Immune System Elastic fibre formation Itgb3 Gene Information Basic Information Ensembl ID: ENSMUSG00000020689 Description: integrin beta 3 [Source:MGI Symbol;Acc:MGI:96612] Location: 11:104498826-104561302 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell stromal cell bone cell megakaryocyte Other: Elastic fibre formation Cell surface interactions at the vascular wall Integrin cell surface interactions Pecam1 Gene Information Basic Information Ensembl ID: ENSMUSG00000020717 Description: platelet/endothelial cell adhesion molecule 1 [Source:MGI Symbol;Acc:MGI:97537] Location: 11:106545043-106641454 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell epithelial cell Other: Innate Immune System Cell surface interactions at the vascular wall Integrin cell surface interactions Sdc1 Gene Information Basic Information Ensembl ID: ENSMUSG00000020592 Description: syndecan 1 [Source:MGI Symbol;Acc:MGI:1349162] Location: 12:8821323-8843715 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte stem cell epithelial cell pneumocyte Naive B cell basal cell plasma cell leukocyte T cell Specialized T cell Other: Cytokine Signaling in Immune system Metabolism of vitamins and cofactors Cell surface interactions at the vascular wall Sele Gene Information Basic Information Ensembl ID: ENSMUSG00000026582 Description: selectin%2C endothelial cell [Source:MGI Symbol;Acc:MGI:98278] Location: 1:163875773-163885246 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell pericyte Other: Cell surface interactions at the vascular wall Sell Gene Information Basic Information Ensembl ID: ENSMUSG00000026581 Description: selectin%2C lymphocyte [Source:MGI Symbol;Acc:MGI:98279] Location: 1:163889551-163911750 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell natural killer cell Regulatory T cell Naive B cell Specialized T cell CD8+ T cell dendritic cell T cell myeloid progenitor cell CD4+ T cell developing T cell Other: Adaptive Immune System Innate Immune System Cell surface interactions at the vascular wall Spn Gene Information Basic Information Ensembl ID: ENSMUSG00000051457 Description: sialophorin [Source:MGI Symbol;Acc:MGI:98384] Location: 7:126731404-126736995 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell natural killer cell monocyte eosinophil Other: Cell surface interactions at the vascular wall Tgfb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000002603 Description: transforming growth factor%2C beta 1 [Source:MGI Symbol;Acc:MGI:98725] Location: 7:25386427-25404502 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell hematopoietic stem cell phagocyte monocyte leukocyte megakaryocyte Other: Cell surface interactions at the vascular wall Non-integrin membrane-ECM interactions Elastic fibre formation Thbd Gene Information Basic Information Ensembl ID: ENSMUSG00000074743 Description: thrombomodulin [Source:MGI Symbol;Acc:MGI:98736] Location: 2:148246386-148250108 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Formation of Fibrin Clot (Clotting Cascade) Cell surface interactions at the vascular wall
Cellular responses to mechanical stimuli Pathway Hierarchies & Genes High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (2 genes) Cellular responses to stimuli Cellular responses to mechanical stimuli Response of endothelial cells to shear stress High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells 2 genes Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (3 genes) Cellular responses to stimuli Cellular responses to mechanical stimuli Response of endothelial cells to shear stress Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells 3 genes	Anxa2 Gene Information Basic Information Ensembl ID: ENSMUSG00000032231 Description: annexin A2 [Source:MGI Symbol;Acc:MGI:88246] Location: 9:69360902-69399077 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell endothelial cell natural killer cell stem cell epithelial cell monocyte Other: Innate Immune System Dissolution of Fibrin Clot Cellular responses to mechanical stimuli Calcrl Gene Information Basic Information Ensembl ID: ENSMUSG00000059588 Description: calcitonin receptor-like [Source:MGI Symbol;Acc:MGI:1926944] Location: 2:84160970-84255755 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell endocardial cell Other: Signaling by GPCR Cellular responses to mechanical stimuli Capns2 Gene Information Basic Information Ensembl ID: ENSMUSG00000078144 Description: calpain%2C small subunit 2 [Source:MGI Symbol;Acc:MGI:1916793] Location: 8:93628035-93629039 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stem cell epithelial cell keratinocyte Other: Degradation of the extracellular matrix Cellular responses to mechanical stimuli Itgb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000025809 Description: integrin beta 1 (fibronectin receptor beta) [Source:MGI Symbol;Acc:MGI:96610] Location: 8:129412135-129459681 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell pericyte stellate cell stromal cell smooth muscle cell fibroblast muscle cell mural cell basal cell kidney cell Other: Laminin interactions Adaptive Immune System Elastic fibre formation Itgb3 Gene Information Basic Information Ensembl ID: ENSMUSG00000020689 Description: integrin beta 3 [Source:MGI Symbol;Acc:MGI:96612] Location: 11:104498826-104561302 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell stromal cell bone cell megakaryocyte Other: Elastic fibre formation Cell surface interactions at the vascular wall Integrin cell surface interactions
Cellular responses to stress Pathway Hierarchies & Genes Amino acids regulate mTORC1 (2 genes) Cellular responses to stimuli Cellular responses to stress Cellular response to starvation Amino acids regulate mTORC1 2 genes Detoxification of Reactive Oxygen Species (5 genes) Cellular responses to stimuli Cellular responses to stress Cellular response to chemical stress Detoxification of Reactive Oxygen Species 5 genes Oxidative Stress Induced Senescence (1 genes) Cellular responses to stimuli Cellular responses to stress Cellular Senescence Oxidative Stress Induced Senescence 1 genes HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (1 genes) Cellular responses to stimuli Cellular responses to stress HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 1 genes Heme signaling (1 genes) Cellular responses to stimuli Cellular responses to stress Heme signaling 1 genes	Atp6v0d2 Gene Information Basic Information Ensembl ID: ENSMUSG00000028238 Description: ATPase%2C H+ transporting%2C lysosomal V0 subunit D2 [Source:MGI Symbol;Acc:MGI:1924415] Location: 4:19876841-19922605 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: kidney cell phagocyte epithelial cell Other: Innate Immune System Cellular responses to stress Signaling by Receptor Tyrosine Kinases Atp6v1b1 Gene Information Basic Information Ensembl ID: ENSMUSG00000006269 Description: ATPase%2C H+ transporting%2C lysosomal V1 subunit B1 [Source:MGI Symbol;Acc:MGI:103285] Location: 6:83719972-83735837 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: kidney cell intercalated cell epithelial cell Other: Innate Immune System Cellular responses to stress Signaling by Receptor Tyrosine Kinases Cybb Gene Information Basic Information Ensembl ID: ENSMUSG00000015340 Description: cytochrome b-245%2C beta polypeptide [Source:MGI Symbol;Acc:MGI:88574] Location: X:9301491-9354010 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: monocyte Other: Adaptive Immune System Innate Immune System Cellular responses to stress Gpx6 Gene Information Basic Information Ensembl ID: ENSMUSG00000004341 Description: glutathione peroxidase 6 [Source:MGI Symbol;Acc:MGI:1922762] Location: 13:21496295-21503794 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cellular responses to stress Mapk10 Gene Information Basic Information Ensembl ID: ENSMUSG00000046709 Description: mitogen-activated protein kinase 10 [Source:MGI Symbol;Acc:MGI:1346863] Location: 5:103055814-103359200 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Cytokine Signaling in Immune system Innate Immune System Cellular responses to stress Ncf4 Gene Information Basic Information Ensembl ID: ENSMUSG00000071715 Description: neutrophil cytosolic factor 4 [Source:MGI Symbol;Acc:MGI:109186] Location: 15:78129001-78146780 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell dendritic cell erythrocyte granulocyte monocyte Other: Adaptive Immune System Innate Immune System Cellular responses to stress Nox4 Gene Information Basic Information Ensembl ID: ENSMUSG00000030562 Description: NADPH oxidase 4 [Source:MGI Symbol;Acc:MGI:1354184] Location: 7:86895304-87047918 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cellular responses to stress Sod3 Gene Information Basic Information Ensembl ID: ENSMUSG00000072941 Description: superoxide dismutase 3%2C extracellular [Source:MGI Symbol;Acc:MGI:103181] Location: 5:52521133-52528760 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stellate cell pericyte stromal cell mural cell tuft cell Other: Cellular responses to stress Tlr4 Gene Information Basic Information Ensembl ID: ENSMUSG00000039005 Description: toll-like receptor 4 [Source:MGI Symbol;Acc:MGI:96824] Location: 4:66745821-66848521 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte Other: Apoptosis Innate Immune System Cellular responses to stress Tubb3 Gene Information Basic Information Ensembl ID: ENSMUSG00000062380 Description: tubulin%2C beta 3 class III [Source:MGI Symbol;Acc:MGI:107813] Location: 8:124138163-124148754 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell neuron motor neuron Other: Cytokine Signaling in Immune system Adaptive Immune System Macroautophagy
Chromatin modifying enzymes Pathway Hierarchies & Genes RMTs methylate histone arginines (1 genes) Chromatin organization Chromatin modifying enzymes RMTs methylate histone arginines 1 genes	Actl6b Gene Information Basic Information Ensembl ID: ENSMUSG00000029712 Description: actin-like 6B [Source:MGI Symbol;Acc:MGI:1933548] Location: 5:137551779-137567844 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Chromatin modifying enzymes RNA Polymerase II Transcription
Cilium Assembly Pathway Hierarchies & Genes VxPx cargo-targeting to cilium (2 genes) Organelle biogenesis and maintenance Cilium Assembly Cargo trafficking to the periciliary membrane 1 genes VxPx cargo-targeting to cilium 1 genes	Rho Gene Information Basic Information Ensembl ID: ENSMUSG00000030324 Description: rhodopsin [Source:MGI Symbol;Acc:MGI:97914] Location: 6:115908709-115916997 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: photoreceptor cell Other: Visual phototransduction Signaling by GPCR Cilium Assembly Tubb3 Gene Information Basic Information Ensembl ID: ENSMUSG00000062380 Description: tubulin%2C beta 3 class III [Source:MGI Symbol;Acc:MGI:107813] Location: 8:124138163-124148754 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell neuron motor neuron Other: Cytokine Signaling in Immune system Adaptive Immune System Macroautophagy
Collagen formation Pathway Hierarchies & Genes Collagen chain trimerization (1 genes) Extracellular matrix organization Collagen formation Collagen biosynthesis and modifying enzymes Collagen chain trimerization 1 genes Assembly of collagen fibrils and other multimeric structures (1 genes) Extracellular matrix organization Collagen formation Assembly of collagen fibrils and other multimeric structures 1 genes Collagen biosynthesis and modifying enzymes (1 genes) Extracellular matrix organization Collagen formation Collagen biosynthesis and modifying enzymes 1 genes	Col17a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000025064 Description: collagen%2C type XVII%2C alpha 1 [Source:MGI Symbol;Acc:MGI:88450] Location: 19:47634783-47680533 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stem cell epithelial cell Other: Adaptive Immune System Collagen formation Cell junction organization Mmp9 Gene Information Basic Information Ensembl ID: ENSMUSG00000017737 Description: matrix metallopeptidase 9 [Source:MGI Symbol;Acc:MGI:97011] Location: 2:164782700-164797770 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell bone cell granulocyte monocyte Other: Degradation of the extracellular matrix Collagen formation Innate Immune System Pcolce2 Gene Information Basic Information Ensembl ID: ENSMUSG00000015354 Description: procollagen C-endopeptidase enhancer 2 [Source:MGI Symbol;Acc:MGI:1923727] Location: 9:95519654-95580149 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stem cell stromal cell Other: Collagen formation
Cytokine Signaling in Immune system Pathway Hierarchies & Genes PKR-mediated signaling (3 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-6 family signaling Interleukin-6 signaling 2 genes Interferon Signaling Antiviral mechanism by IFN-stimulated genes PKR-mediated signaling 1 genes Interleukin-1 signaling (3 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-1 family signaling Interleukin-1 signaling 3 genes Interleukin-12 signaling (1 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-12 family signaling Interleukin-12 signaling 1 genes Interleukin-15 signaling (1 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-2 family signaling Interleukin-15 signaling 1 genes Interleukin-18 signaling (1 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-1 family signaling Interleukin-18 signaling 1 genes Interleukin-2 signaling (1 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-2 family signaling Interleukin-2 signaling 1 genes Interleukin-21 signaling (1 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-2 family signaling Interleukin-21 signaling 1 genes Interleukin-23 signaling (1 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-12 family signaling Interleukin-23 signaling 1 genes Interleukin-33 signaling (1 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-1 family signaling Interleukin-33 signaling 1 genes Interleukin-35 Signalling (1 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-12 family signaling Interleukin-35 Signalling 1 genes PKR-mediated signaling (1 genes) Immune System Cytokine Signaling in Immune system Interferon Signaling Antiviral mechanism by IFN-stimulated genes PKR-mediated signaling 1 genes Regulation of IFNG signaling (2 genes) Immune System Cytokine Signaling in Immune system Interferon Signaling Interferon gamma signaling Regulation of IFNG signaling 2 genes Interleukin-10 signaling (1 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-10 signaling 1 genes Interleukin-17 signaling (1 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-17 signaling 1 genes Interleukin-4 and Interleukin-13 signaling (2 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-4 and Interleukin-13 signaling 2 genes Interleukin-7 signaling (1 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Interleukin-7 signaling 1 genes Other interleukin signaling (4 genes) Immune System Cytokine Signaling in Immune system Signaling by Interleukins Other interleukin signaling 4 genes TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (3 genes) Immune System Cytokine Signaling in Immune system TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 3 genes TNFs bind their physiological receptors (8 genes) Immune System Cytokine Signaling in Immune system TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors 8 genes	Ager Gene Information Basic Information Ensembl ID: ENSMUSG00000015452 Description: advanced glycosylation end product-specific receptor [Source:MGI Symbol;Acc:MGI:893592] Location: 17:34816836-34819910 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell pneumocyte Other: Cytokine Signaling in Immune system Innate Immune System Cd27 Gene Information Basic Information Ensembl ID: ENSMUSG00000030336 Description: CD27 antigen [Source:MGI Symbol;Acc:MGI:88326] Location: 6:125209585-125213973 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell hematopoietic stem cell Specialized T cell CD8+ T cell T cell memory B cell Other: Cytokine Signaling in Immune system Cd4 Gene Information Basic Information Ensembl ID: ENSMUSG00000023274 Description: CD4 antigen [Source:MGI Symbol;Acc:MGI:88335] Location: 6:124841655-124865184 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell Regulatory T cell CD4+ T cell dendritic cell T cell Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Cd40 Gene Information Basic Information Ensembl ID: ENSMUSG00000017652 Description: CD40 antigen [Source:MGI Symbol;Acc:MGI:88336] Location: 2:164897547-164914868 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell Other: Cytokine Signaling in Immune system Adaptive Immune System Cd40lg Gene Information Basic Information Ensembl ID: ENSMUSG00000031132 Description: CD40 ligand [Source:MGI Symbol;Acc:MGI:88337] Location: X:56257503-56269402 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: CD4+ T cell Other: Cytokine Signaling in Immune system Adaptive Immune System Csf1r Gene Information Basic Information Ensembl ID: ENSMUSG00000024621 Description: colony stimulating factor 1 receptor [Source:MGI Symbol;Acc:MGI:1339758] Location: 18:61233670-61265221 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell phagocyte myeloid cell antigen presenting cell T cell leukocyte macrophage monocyte stem cell myeloid progenitor cell Other: Cytokine Signaling in Immune system Ifng Gene Information Basic Information Ensembl ID: ENSMUSG00000055170 Description: interferon gamma [Source:MGI Symbol;Acc:MGI:107656] Location: 10:118276951-118281797 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell Other: Cytokine Signaling in Immune system Ifngr1 Gene Information Basic Information Ensembl ID: ENSMUSG00000020009 Description: interferon gamma receptor 1 [Source:MGI Symbol;Acc:MGI:107655] Location: 10:19467697-19485977 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell developing T cell hematopoietic stem cell phagocyte monocyte Specialized T cell CD4+ T cell T cell effector T cell Other: Cytokine Signaling in Immune system Il10 Gene Information Basic Information Ensembl ID: ENSMUSG00000016529 Description: interleukin 10 [Source:MGI Symbol;Acc:MGI:96537] Location: 1:130947582-130952711 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Regulatory T cell macrophage Other: Cytokine Signaling in Immune system Il12a Gene Information Basic Information Ensembl ID: ENSMUSG00000027776 Description: interleukin 12a [Source:MGI Symbol;Acc:MGI:96539] Location: 3:68597977-68605880 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Il12rb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000000791 Description: interleukin 12 receptor%2C beta 1 [Source:MGI Symbol;Acc:MGI:104579] Location: 8:71261093-71274068 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Il13ra1 Gene Information Basic Information Ensembl ID: ENSMUSG00000017057 Description: interleukin 13 receptor%2C alpha 1 [Source:MGI Symbol;Acc:MGI:105052] Location: X:35375763-35434912 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell smooth muscle cell tuft cell Other: Cytokine Signaling in Immune system Il18r1 Gene Information Basic Information Ensembl ID: ENSMUSG00000026070 Description: interleukin 18 receptor 1 [Source:MGI Symbol;Acc:MGI:105383] Location: 1:40504712-40540014 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell natural killer cell CD4+ T cell Specialized T cell innate lymphoid cell leukocyte Other: Cytokine Signaling in Immune system Il1r1 Gene Information Basic Information Ensembl ID: ENSMUSG00000026072 Description: interleukin 1 receptor%2C type I [Source:MGI Symbol;Acc:MGI:96545] Location: 1:40264240-40356417 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell mural cell Other: Cytokine Signaling in Immune system Il1r2 Gene Information Basic Information Ensembl ID: ENSMUSG00000026073 Description: interleukin 1 receptor%2C type II [Source:MGI Symbol;Acc:MGI:96546] Location: 1:40113239-40164391 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell dendritic cell granulocyte monocyte Other: Cytokine Signaling in Immune system Il1rl1 Gene Information Basic Information Ensembl ID: ENSMUSG00000026069 Description: interleukin 1 receptor-like 1 [Source:MGI Symbol;Acc:MGI:98427] Location: 1:40468730-40504575 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell natural killer cell mast cell Other: Cytokine Signaling in Immune system Intracellular signaling by second messengers Il21r Gene Information Basic Information Ensembl ID: ENSMUSG00000030745 Description: interleukin 21 receptor [Source:MGI Symbol;Acc:MGI:1890475] Location: 7:125202601-125232742 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell Naive B cell hematopoietic stem cell Specialized T cell Other: Cytokine Signaling in Immune system Il23r Gene Information Basic Information Ensembl ID: ENSMUSG00000049093 Description: interleukin 23 receptor [Source:MGI Symbol;Acc:MGI:2181693] Location: 6:67399916-67468839 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Il2ra Gene Information Basic Information Ensembl ID: ENSMUSG00000026770 Description: interleukin 2 receptor%2C alpha chain [Source:MGI Symbol;Acc:MGI:96549] Location: 2:11647618-11698004 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Regulatory T cell T cell CD8+ T cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades Il2rb Gene Information Basic Information Ensembl ID: ENSMUSG00000068227 Description: interleukin 2 receptor%2C beta chain [Source:MGI Symbol;Acc:MGI:96550] Location: 15:78363456-78379471 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell developing T cell Specialized T cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades Il4ra Gene Information Basic Information Ensembl ID: ENSMUSG00000030748 Description: interleukin 4 receptor%2C alpha [Source:MGI Symbol;Acc:MGI:105367] Location: 7:125151292-125178646 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell macrophage Other: Cytokine Signaling in Immune system Il6 Gene Information Basic Information Ensembl ID: ENSMUSG00000025746 Description: interleukin 6 [Source:MGI Symbol;Acc:MGI:96559] Location: 5:30218112-30224979 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stem cell endothelial cell basophil eosinophil mural cell Other: Cytokine Signaling in Immune system Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MAPK family signaling cascades Il6ra Gene Information Basic Information Ensembl ID: ENSMUSG00000027947 Description: interleukin 6 receptor%2C alpha [Source:MGI Symbol;Acc:MGI:105304] Location: 3:89771366-89820503 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte monocyte Other: Cytokine Signaling in Immune system MAPK family signaling cascades Il7r Gene Information Basic Information Ensembl ID: ENSMUSG00000003882 Description: interleukin 7 receptor [Source:MGI Symbol;Acc:MGI:96562] Location: 15:9505874-9530262 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell CD8+ T cell dendritic cell developing T cell Regulatory T cell mast cell memory T cell effector T cell innate lymphoid cell Other: Cytokine Signaling in Immune system Membrane Trafficking Mapk10 Gene Information Basic Information Ensembl ID: ENSMUSG00000046709 Description: mitogen-activated protein kinase 10 [Source:MGI Symbol;Acc:MGI:1346863] Location: 5:103055814-103359200 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Cytokine Signaling in Immune system Innate Immune System Cellular responses to stress Sdc1 Gene Information Basic Information Ensembl ID: ENSMUSG00000020592 Description: syndecan 1 [Source:MGI Symbol;Acc:MGI:1349162] Location: 12:8821323-8843715 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte stem cell epithelial cell pneumocyte Naive B cell basal cell plasma cell leukocyte T cell Specialized T cell Other: Cytokine Signaling in Immune system Metabolism of vitamins and cofactors Cell surface interactions at the vascular wall Snap25 Gene Information Basic Information Ensembl ID: ENSMUSG00000027273 Description: synaptosomal-associated protein 25 [Source:MGI Symbol;Acc:MGI:98331] Location: 2:136555373-136624348 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron endocrine cell Other: Cytokine Signaling in Immune system Innate Immune System Transmission across Chemical Synapses Stat3 Gene Information Basic Information Ensembl ID: ENSMUSG00000004040 Description: signal transducer and activator of transcription 3 [Source:MGI Symbol;Acc:MGI:103038] Location: 11:100775924-100830366 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Signaling by Non-Receptor Tyrosine Kinases Signaling by Receptor Tyrosine Kinases Tnfrsf13b Gene Information Basic Information Ensembl ID: ENSMUSG00000010142 Description: tumor necrosis factor receptor superfamily%2C member 13b [Source:MGI Symbol;Acc:MGI:1889411] Location: 11:61017581-61040198 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Naive B cell Follicular B cell memory B cell dendritic cell Other: Cytokine Signaling in Immune system Tnfrsf13c Gene Information Basic Information Ensembl ID: ENSMUSG00000068105 Description: tumor necrosis factor receptor superfamily%2C member 13c [Source:MGI Symbol;Acc:MGI:1919299] Location: 15:82105944-82108570 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Naive B cell Follicular B cell Other: Cytokine Signaling in Immune system Tnfrsf18 Gene Information Basic Information Ensembl ID: ENSMUSG00000041954 Description: tumor necrosis factor receptor superfamily%2C member 18 [Source:MGI Symbol;Acc:MGI:894675] Location: 4:156110621-156113352 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell developing T cell Regulatory T cell CD4+ T cell T cell Other: Cytokine Signaling in Immune system Tnfrsf4 Gene Information Basic Information Ensembl ID: ENSMUSG00000029075 Description: tumor necrosis factor receptor superfamily%2C member 4 [Source:MGI Symbol;Acc:MGI:104512] Location: 4:156098300-156101069 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell Regulatory T cell CD4+ T cell Other: Cytokine Signaling in Immune system Tnfrsf8 Gene Information Basic Information Ensembl ID: ENSMUSG00000028602 Description: tumor necrosis factor receptor superfamily%2C member 8 [Source:MGI Symbol;Acc:MGI:99908] Location: 4:144993707-145041734 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Tnfrsf9 Gene Information Basic Information Ensembl ID: ENSMUSG00000028965 Description: tumor necrosis factor receptor superfamily%2C member 9 [Source:MGI Symbol;Acc:MGI:1101059] Location: 4:150999019-151030559 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Regulatory T cell mast cell Other: Cytokine Signaling in Immune system Tnfsf18 Gene Information Basic Information Ensembl ID: ENSMUSG00000066755 Description: tumor necrosis factor (ligand) superfamily%2C member 18 [Source:MGI Symbol;Acc:MGI:2673064] Location: 1:161322224-161332859 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Tnfsf4 Gene Information Basic Information Ensembl ID: ENSMUSG00000026700 Description: tumor necrosis factor (ligand) superfamily%2C member 4 [Source:MGI Symbol;Acc:MGI:104511] Location: 1:161222980-161245981 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Tubb3 Gene Information Basic Information Ensembl ID: ENSMUSG00000062380 Description: tubulin%2C beta 3 class III [Source:MGI Symbol;Acc:MGI:107813] Location: 8:124138163-124148754 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell neuron motor neuron Other: Cytokine Signaling in Immune system Adaptive Immune System Macroautophagy
Death Receptor Signaling Pathway Hierarchies & Genes Axonal growth inhibition (RHOA activation) (1 genes) Signal Transduction Death Receptor Signaling p75 NTR receptor-mediated signalling p75NTR regulates axonogenesis Axonal growth inhibition (RHOA activation) 1 genes FasL/ CD95L signaling (2 genes) Signal Transduction Death Receptor Signaling FasL/ CD95L signaling 2 genes	Fas Gene Information Basic Information Ensembl ID: ENSMUSG00000024778 Description: Fas cell surface death receptor [Source:MGI Symbol;Acc:MGI:95484] Location: 19:34268066-34305172 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell smooth muscle cell Other: Apoptosis Regulated Necrosis Death Receptor Signaling Fasl Gene Information Basic Information Ensembl ID: ENSMUSG00000000817 Description: Fas ligand [Source:MGI Symbol;Acc:MGI:99255] Location: 1:161608258-161616064 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell CD8+ T cell T cell Other: Apoptosis Regulated Necrosis Death Receptor Signaling Ngfr Gene Information Basic Information Ensembl ID: ENSMUSG00000000120 Description: nerve growth factor receptor (TNFR superfamily%2C member 16) [Source:MGI Symbol;Acc:MGI:97323] Location: 11:95459644-95478561 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Death Receptor Signaling
Degradation of the extracellular matrix Pathway Hierarchies & Genes Activation of Matrix Metalloproteinases (4 genes) Extracellular matrix organization Degradation of the extracellular matrix 3 genes Collagen degradation Activation of Matrix Metalloproteinases 1 genes	Acan Gene Information Basic Information Ensembl ID: ENSMUSG00000030607 Description: aggrecan [Source:MGI Symbol;Acc:MGI:99602] Location: 7:78703231-78764847 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stromal cell smooth muscle cell osteoblast chondrocyte Other: Degradation of the extracellular matrix ECM proteoglycans Metabolism of carbohydrates and carbohydrate derivatives Capns2 Gene Information Basic Information Ensembl ID: ENSMUSG00000078144 Description: calpain%2C small subunit 2 [Source:MGI Symbol;Acc:MGI:1916793] Location: 8:93628035-93629039 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stem cell epithelial cell keratinocyte Other: Degradation of the extracellular matrix Cellular responses to mechanical stimuli Cd44 Gene Information Basic Information Ensembl ID: ENSMUSG00000005087 Description: CD44 antigen [Source:MGI Symbol;Acc:MGI:88338] Location: 2:102641486-102732010 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell phagocyte monocyte granulocyte neutrophil macrophage progenitor cell Other: Cell surface interactions at the vascular wall Integrin cell surface interactions Innate Immune System Mmp9 Gene Information Basic Information Ensembl ID: ENSMUSG00000017737 Description: matrix metallopeptidase 9 [Source:MGI Symbol;Acc:MGI:97011] Location: 2:164782700-164797770 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell bone cell granulocyte monocyte Other: Degradation of the extracellular matrix Collagen formation Innate Immune System
Dissolution of Fibrin Clot Pathway Hierarchies & Genes Dissolution of Fibrin Clot (2 genes) Hemostasis Dissolution of Fibrin Clot 2 genes	Anxa2 Gene Information Basic Information Ensembl ID: ENSMUSG00000032231 Description: annexin A2 [Source:MGI Symbol;Acc:MGI:88246] Location: 9:69360902-69399077 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell endothelial cell natural killer cell stem cell epithelial cell monocyte Other: Innate Immune System Dissolution of Fibrin Clot Cellular responses to mechanical stimuli Hrg Gene Information Basic Information Ensembl ID: ENSMUSG00000022877 Description: histidine-rich glycoprotein [Source:MGI Symbol;Acc:MGI:2146636] Location: 16:22769822-22780406 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Dissolution of Fibrin Clot Platelet activation, signaling and aggregation
ECM proteoglycans Pathway Hierarchies & Genes ECM proteoglycans (7 genes) Extracellular matrix organization ECM proteoglycans 7 genes	Acan Gene Information Basic Information Ensembl ID: ENSMUSG00000030607 Description: aggrecan [Source:MGI Symbol;Acc:MGI:99602] Location: 7:78703231-78764847 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stromal cell smooth muscle cell osteoblast chondrocyte Other: Degradation of the extracellular matrix ECM proteoglycans Metabolism of carbohydrates and carbohydrate derivatives Comp Gene Information Basic Information Ensembl ID: ENSMUSG00000031849 Description: cartilage oligomeric matrix protein [Source:MGI Symbol;Acc:MGI:88469] Location: 8:70826208-70834716 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stromal cell Other: Integrin cell surface interactions ECM proteoglycans Itga2 Gene Information Basic Information Ensembl ID: ENSMUSG00000015533 Description: integrin alpha 2 [Source:MGI Symbol;Acc:MGI:96600] Location: 13:114969617-115068636 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Specialized T cell Other: Integrin cell surface interactions Non-integrin membrane-ECM interactions ECM proteoglycans Itga8 Gene Information Basic Information Ensembl ID: ENSMUSG00000026768 Description: integrin alpha 8 [Source:MGI Symbol;Acc:MGI:109442] Location: 2:12111443-12306733 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast smooth muscle cell epithelial cell mesenchymal stem cell Other: Elastic fibre formation Integrin cell surface interactions ECM proteoglycans Itgax Gene Information Basic Information Ensembl ID: ENSMUSG00000030789 Description: integrin alpha X [Source:MGI Symbol;Acc:MGI:96609] Location: 7:127728719-127749829 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell phagocyte macrophage dendritic cell Other: Innate Immune System Cell surface interactions at the vascular wall Integrin cell surface interactions Itgb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000025809 Description: integrin beta 1 (fibronectin receptor beta) [Source:MGI Symbol;Acc:MGI:96610] Location: 8:129412135-129459681 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell pericyte stellate cell stromal cell smooth muscle cell fibroblast muscle cell mural cell basal cell kidney cell Other: Laminin interactions Adaptive Immune System Elastic fibre formation Itgb3 Gene Information Basic Information Ensembl ID: ENSMUSG00000020689 Description: integrin beta 3 [Source:MGI Symbol;Acc:MGI:96612] Location: 11:104498826-104561302 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell stromal cell bone cell megakaryocyte Other: Elastic fibre formation Cell surface interactions at the vascular wall Integrin cell surface interactions
Elastic fibre formation Pathway Hierarchies & Genes Molecules associated with elastic fibres (8 genes) Extracellular matrix organization Elastic fibre formation Molecules associated with elastic fibres 8 genes	Bmp2 Gene Information Basic Information Ensembl ID: ENSMUSG00000027358 Description: bone morphogenetic protein 2 [Source:MGI Symbol;Acc:MGI:88177] Location: 2:133394079-133404805 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stromal cell Other: Elastic fibre formation Signaling by TGFB family members Fbln5 Gene Information Basic Information Ensembl ID: ENSMUSG00000021186 Description: fibulin 5 [Source:MGI Symbol;Acc:MGI:1346091] Location: 12:101712824-101785314 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell epithelial cell glial cell stromal cell smooth muscle cell Other: Elastic fibre formation Itga8 Gene Information Basic Information Ensembl ID: ENSMUSG00000026768 Description: integrin alpha 8 [Source:MGI Symbol;Acc:MGI:109442] Location: 2:12111443-12306733 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast smooth muscle cell epithelial cell mesenchymal stem cell Other: Elastic fibre formation Integrin cell surface interactions ECM proteoglycans Itgb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000025809 Description: integrin beta 1 (fibronectin receptor beta) [Source:MGI Symbol;Acc:MGI:96610] Location: 8:129412135-129459681 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell pericyte stellate cell stromal cell smooth muscle cell fibroblast muscle cell mural cell basal cell kidney cell Other: Laminin interactions Adaptive Immune System Elastic fibre formation Itgb3 Gene Information Basic Information Ensembl ID: ENSMUSG00000020689 Description: integrin beta 3 [Source:MGI Symbol;Acc:MGI:96612] Location: 11:104498826-104561302 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell stromal cell bone cell megakaryocyte Other: Elastic fibre formation Cell surface interactions at the vascular wall Integrin cell surface interactions Mfap4 Gene Information Basic Information Ensembl ID: ENSMUSG00000042436 Description: microfibrillar-associated protein 4 [Source:MGI Symbol;Acc:MGI:1342276] Location: 11:61376257-61379726 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stellate cell stem cell neuron mesenchymal cell cancer cell Other: Elastic fibre formation Mfap5 Gene Information Basic Information Ensembl ID: ENSMUSG00000030116 Description: microfibrillar associated protein 5 [Source:MGI Symbol;Acc:MGI:1354387] Location: 6:122482804-122506249 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stem cell stromal cell Other: Elastic fibre formation Tgfb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000002603 Description: transforming growth factor%2C beta 1 [Source:MGI Symbol;Acc:MGI:98725] Location: 7:25386427-25404502 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell hematopoietic stem cell phagocyte monocyte leukocyte megakaryocyte Other: Cell surface interactions at the vascular wall Non-integrin membrane-ECM interactions Elastic fibre formation
Factors involved in megakaryocyte development and platelet production Pathway Hierarchies & Genes Kinesins (2 genes) Hemostasis Factors involved in megakaryocyte development and platelet production 1 genes Kinesins 1 genes	Gata3 Gene Information Basic Information Ensembl ID: ENSMUSG00000015619 Description: GATA binding protein 3 [Source:MGI Symbol;Acc:MGI:95663] Location: 2:9861889-9894845 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Regulatory T cell epithelial cell stem cell CD4+ T cell innate lymphoid cell developing T cell mesangial cell Other: Post-translational protein modification RNA Polymerase II Transcription Signaling by Nuclear Receptors Tubb3 Gene Information Basic Information Ensembl ID: ENSMUSG00000062380 Description: tubulin%2C beta 3 class III [Source:MGI Symbol;Acc:MGI:107813] Location: 8:124138163-124148754 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell neuron motor neuron Other: Cytokine Signaling in Immune system Adaptive Immune System Macroautophagy
Fibronectin matrix formation Pathway Hierarchies & Genes Fibronectin matrix formation (1 genes) Extracellular matrix organization Fibronectin matrix formation 1 genes	Itgb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000025809 Description: integrin beta 1 (fibronectin receptor beta) [Source:MGI Symbol;Acc:MGI:96610] Location: 8:129412135-129459681 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell pericyte stellate cell stromal cell smooth muscle cell fibroblast muscle cell mural cell basal cell kidney cell Other: Laminin interactions Adaptive Immune System Elastic fibre formation
Formation of Fibrin Clot (Clotting Cascade) Pathway Hierarchies & Genes Common Pathway of Fibrin Clot Formation (2 genes) Hemostasis Formation of Fibrin Clot (Clotting Cascade) Common Pathway of Fibrin Clot Formation 2 genes Extrinsic Pathway of Fibrin Clot Formation (1 genes) Hemostasis Formation of Fibrin Clot (Clotting Cascade) Extrinsic Pathway of Fibrin Clot Formation 1 genes Intrinsic Pathway of Fibrin Clot Formation (1 genes) Hemostasis Formation of Fibrin Clot (Clotting Cascade) Intrinsic Pathway of Fibrin Clot Formation 1 genes	F13a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000039109 Description: coagulation factor XIII%2C A1 subunit [Source:MGI Symbol;Acc:MGI:1921395] Location: 13:37051152-37234220 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: hematopoietic stem cell phagocyte monocyte erythroid lineage cell T cell macrophage Other: Formation of Fibrin Clot (Clotting Cascade) Platelet activation, signaling and aggregation F3 Gene Information Basic Information Ensembl ID: ENSMUSG00000028128 Description: coagulation factor III [Source:MGI Symbol;Acc:MGI:88381] Location: 3:121517186-121528697 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: bergmann glial cell neuron stem cell fibroblast epithelial cell Other: Formation of Fibrin Clot (Clotting Cascade) Thbd Gene Information Basic Information Ensembl ID: ENSMUSG00000074743 Description: thrombomodulin [Source:MGI Symbol;Acc:MGI:98736] Location: 2:148246386-148250108 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Formation of Fibrin Clot (Clotting Cascade) Cell surface interactions at the vascular wall Vwf Gene Information Basic Information Ensembl ID: ENSMUSG00000001930 Description: Von Willebrand factor [Source:MGI Symbol;Acc:MGI:98941] Location: 6:125523737-125663642 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell endocardial cell endodermal cell hematopoietic stem cell Other: Formation of Fibrin Clot (Clotting Cascade) Integrin cell surface interactions Integrin signaling
Innate Immune System Pathway Hierarchies & Genes Advanced glycosylation endproduct receptor signaling (1 genes) Immune System Innate Immune System Toll-like Receptor Cascades Toll Like Receptor 4 (TLR4) Cascade MyD88-independent TLR4 cascade TRIF (TICAM1)-mediated TLR4 signaling DDX58/IFIH1-mediated induction of interferon-alpha/beta TRAF6 mediated NF-kB activation Advanced glycosylation endproduct receptor signaling 1 genes FCERI mediated MAPK activation (1 genes) Immune System Innate Immune System Toll-like Receptor Cascades Toll Like Receptor 3 (TLR3) Cascade MAP kinase activation MAPK targets/ Nuclear events mediated by MAP kinases Activation of the AP-1 family of transcription factors Fc epsilon receptor (FCERI) signaling FCERI mediated MAPK activation 1 genes Neutrophil degranulation (2 genes) Immune System Innate Immune System Toll-like Receptor Cascades Toll Like Receptor 4 (TLR4) Cascade MyD88-independent TLR4 cascade TRIF (TICAM1)-mediated TLR4 signaling Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 1 genes Neutrophil degranulation 1 genes Neutrophil degranulation (1 genes) Immune System Innate Immune System Complement cascade Initial triggering of complement Creation of C4 and C2 activators Lectin pathway of complement activation Ficolins bind to repetitive carbohydrate structures on the target cell surface Neutrophil degranulation 1 genes Neutrophil degranulation (2 genes) Immune System Innate Immune System Antimicrobial peptides Defensins Beta defensins 1 genes Toll-like Receptor Cascades Regulation of TLR by endogenous ligand Neutrophil degranulation 1 genes Alpha-defensins (1 genes) Immune System Innate Immune System Antimicrobial peptides Defensins Alpha-defensins 1 genes Neutrophil degranulation (1 genes) Immune System Innate Immune System Toll-like Receptor Cascades Regulation of TLR by endogenous ligand Neutrophil degranulation 1 genes Neutrophil degranulation (3 genes) Immune System Innate Immune System Complement cascade Regulation of Complement cascade 2 genes Neutrophil degranulation 1 genes Neutrophil degranulation (1 genes) Immune System Innate Immune System Toll-like Receptor Cascades Toll Like Receptor 4 (TLR4) Cascade Neutrophil degranulation 1 genes DAP12 signaling (1 genes) Immune System Innate Immune System DAP12 interactions DAP12 signaling 1 genes FCGR activation (1 genes) Immune System Innate Immune System Fcgamma receptor (FCGR) dependent phagocytosis FCGR activation 1 genes Neutrophil degranulation (5 genes) Immune System Innate Immune System ROS and RNS production in phagocytes 4 genes Neutrophil degranulation 1 genes Terminal pathway of complement (1 genes) Immune System Innate Immune System Complement cascade Terminal pathway of complement 1 genes Trafficking and processing of endosomal TLR (2 genes) Immune System Innate Immune System Toll-like Receptor Cascades Trafficking and processing of endosomal TLR 2 genes Neutrophil degranulation (16 genes) Immune System Innate Immune System Neutrophil degranulation 16 genes	Abca13 Gene Information Basic Information Ensembl ID: ENSMUSG00000004668 Description: ATP-binding cassette%2C sub-family A member 13 [Source:MGI Symbol;Acc:MGI:2388707] Location: 11:9141942-9634259 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell hematopoietic stem cell Other: Innate Immune System Ager Gene Information Basic Information Ensembl ID: ENSMUSG00000015452 Description: advanced glycosylation end product-specific receptor [Source:MGI Symbol;Acc:MGI:893592] Location: 17:34816836-34819910 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell pneumocyte Other: Cytokine Signaling in Immune system Innate Immune System Anxa2 Gene Information Basic Information Ensembl ID: ENSMUSG00000032231 Description: annexin A2 [Source:MGI Symbol;Acc:MGI:88246] Location: 9:69360902-69399077 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell endothelial cell natural killer cell stem cell epithelial cell monocyte Other: Innate Immune System Dissolution of Fibrin Clot Cellular responses to mechanical stimuli Arg1 Gene Information Basic Information Ensembl ID: ENSMUSG00000019987 Description: arginase%2C liver [Source:MGI Symbol;Acc:MGI:88070] Location: 10:24791119-24803382 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Metabolism of amino acids and derivatives Atp6v0d2 Gene Information Basic Information Ensembl ID: ENSMUSG00000028238 Description: ATPase%2C H+ transporting%2C lysosomal V0 subunit D2 [Source:MGI Symbol;Acc:MGI:1924415] Location: 4:19876841-19922605 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: kidney cell phagocyte epithelial cell Other: Innate Immune System Cellular responses to stress Signaling by Receptor Tyrosine Kinases Atp6v1b1 Gene Information Basic Information Ensembl ID: ENSMUSG00000006269 Description: ATPase%2C H+ transporting%2C lysosomal V1 subunit B1 [Source:MGI Symbol;Acc:MGI:103285] Location: 6:83719972-83735837 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: kidney cell intercalated cell epithelial cell Other: Innate Immune System Cellular responses to stress Signaling by Receptor Tyrosine Kinases Bst1 Gene Information Basic Information Ensembl ID: ENSMUSG00000029082 Description: bone marrow stromal cell antigen 1 [Source:MGI Symbol;Acc:MGI:105370] Location: 5:43976227-44001328 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell macrophage Other: Innate Immune System Metabolism of vitamins and cofactors Post-translational protein modification C5ar1 Gene Information Basic Information Ensembl ID: ENSMUSG00000049130 Description: complement component 5a receptor 1 [Source:MGI Symbol;Acc:MGI:88232] Location: 7:15980668-15993465 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell phagocyte granulocyte myeloid cell T cell monocyte macrophage leukocyte Other: Innate Immune System Signaling by GPCR Ccr6 Gene Information Basic Information Ensembl ID: ENSMUSG00000040899 Description: C-C motif chemokine receptor 6 [Source:MGI Symbol;Acc:MGI:1333797] Location: 17:8454875-8475973 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: memory B cell innate lymphoid cell Other: Innate Immune System Signaling by GPCR Cd14 Gene Information Basic Information Ensembl ID: ENSMUSG00000051439 Description: CD14 antigen [Source:MGI Symbol;Acc:MGI:88318] Location: 18:36858120-36859851 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell dendritic cell phagocyte monocyte microglia granulocyte myeloid cell T cell leukocyte neutrophil macrophage Other: Apoptosis Innate Immune System Cd19 Gene Information Basic Information Ensembl ID: ENSMUSG00000030724 Description: CD19 antigen [Source:MGI Symbol;Acc:MGI:88319] Location: 7:126007622-126014061 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Naive B cell Follicular B cell memory B cell Other: Adaptive Immune System Innate Immune System Intracellular signaling by second messengers Cd36 Gene Information Basic Information Ensembl ID: ENSMUSG00000002944 Description: CD36 molecule [Source:MGI Symbol;Acc:MGI:107899] Location: 5:17986688-18093799 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: macrophage Other: Adaptive Immune System Integration of energy metabolism Innate Immune System Cd4 Gene Information Basic Information Ensembl ID: ENSMUSG00000023274 Description: CD4 antigen [Source:MGI Symbol;Acc:MGI:88335] Location: 6:124841655-124865184 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell Regulatory T cell CD4+ T cell dendritic cell T cell Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Cd44 Gene Information Basic Information Ensembl ID: ENSMUSG00000005087 Description: CD44 antigen [Source:MGI Symbol;Acc:MGI:88338] Location: 2:102641486-102732010 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell phagocyte monocyte granulocyte neutrophil macrophage progenitor cell Other: Cell surface interactions at the vascular wall Integrin cell surface interactions Innate Immune System Cr2 Gene Information Basic Information Ensembl ID: ENSMUSG00000026616 Description: complement receptor 2 [Source:MGI Symbol;Acc:MGI:88489] Location: 1:194819119-194859024 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Naive B cell Other: Innate Immune System Cxcr1 Gene Information Basic Information Ensembl ID: ENSMUSG00000048480 Description: C-X-C motif chemokine receptor 1 [Source:MGI Symbol;Acc:MGI:2448715] Location: 1:74230944-74233790 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Signaling by GPCR Cxcr2 Gene Information Basic Information Ensembl ID: ENSMUSG00000026180 Description: C-X-C motif chemokine receptor 2 [Source:MGI Symbol;Acc:MGI:105303] Location: 1:74193150-74200405 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell granulocyte Other: Innate Immune System Signaling by GPCR Cybb Gene Information Basic Information Ensembl ID: ENSMUSG00000015340 Description: cytochrome b-245%2C beta polypeptide [Source:MGI Symbol;Acc:MGI:88574] Location: X:9301491-9354010 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: monocyte Other: Adaptive Immune System Innate Immune System Cellular responses to stress Fcgr1 Gene Information Basic Information Ensembl ID: ENSMUSG00000015947 Description: Fc receptor%2C IgG%2C high affinity I [Source:MGI Symbol;Acc:MGI:95498] Location: 3:96190225-96201285 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte antigen presenting cell macrophage dendritic cell monocyte hematopoietic cell neutrophil Other: Adaptive Immune System Innate Immune System Fcnb Gene Information Basic Information Ensembl ID: ENSMUSG00000026835 Description: ficolin B [Source:MGI Symbol;Acc:MGI:1341158] Location: 2:27966390-27974897 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell developing T cell Other: Innate Immune System Hc Gene Information Basic Information Ensembl ID: ENSMUSG00000026874 Description: hemolytic complement [Source:MGI Symbol;Acc:MGI:96031] Location: 2:34873343-34951450 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pneumocyte Other: Innate Immune System Signaling by GPCR Itgal Gene Information Basic Information Ensembl ID: ENSMUSG00000030830 Description: integrin alpha L [Source:MGI Symbol;Acc:MGI:96606] Location: 7:126895432-126934310 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell CD4+ T cell CD8+ T cell monocyte Specialized T cell Other: Adaptive Immune System Innate Immune System Cell surface interactions at the vascular wall Itgam Gene Information Basic Information Ensembl ID: ENSMUSG00000030786 Description: integrin alpha M [Source:MGI Symbol;Acc:MGI:96607] Location: 7:127661812-127717663 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell phagocyte macrophage monocyte myeloid cell dendritic cell microglia myeloid derived suppressor cell immune cell Other: Innate Immune System Cell surface interactions at the vascular wall Integrin cell surface interactions Itgax Gene Information Basic Information Ensembl ID: ENSMUSG00000030789 Description: integrin alpha X [Source:MGI Symbol;Acc:MGI:96609] Location: 7:127728719-127749829 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell phagocyte macrophage dendritic cell Other: Innate Immune System Cell surface interactions at the vascular wall Integrin cell surface interactions Klrk1 Gene Information Basic Information Ensembl ID: ENSMUSG00000030149 Description: killer cell lectin-like receptor subfamily K%2C member 1 [Source:MGI Symbol;Acc:MGI:1196250] Location: 6:129587286-129600827 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell developing T cell Other: Adaptive Immune System Innate Immune System Lamp1 Gene Information Basic Information Ensembl ID: ENSMUSG00000031447 Description: lysosomal-associated membrane protein 1 [Source:MGI Symbol;Acc:MGI:96745] Location: 8:13209161-13225338 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stem cell phagocyte microglia monocyte antigen presenting cell basal cell macrophage erythroblast epithelial cell embryonic cell Other: Innate Immune System Mapk10 Gene Information Basic Information Ensembl ID: ENSMUSG00000046709 Description: mitogen-activated protein kinase 10 [Source:MGI Symbol;Acc:MGI:1346863] Location: 5:103055814-103359200 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Cytokine Signaling in Immune system Innate Immune System Cellular responses to stress Mmp9 Gene Information Basic Information Ensembl ID: ENSMUSG00000017737 Description: matrix metallopeptidase 9 [Source:MGI Symbol;Acc:MGI:97011] Location: 2:164782700-164797770 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell bone cell granulocyte monocyte Other: Degradation of the extracellular matrix Collagen formation Innate Immune System Ncf4 Gene Information Basic Information Ensembl ID: ENSMUSG00000071715 Description: neutrophil cytosolic factor 4 [Source:MGI Symbol;Acc:MGI:109186] Location: 15:78129001-78146780 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell dendritic cell erythrocyte granulocyte monocyte Other: Adaptive Immune System Innate Immune System Cellular responses to stress Nos2 Gene Information Basic Information Ensembl ID: ENSMUSG00000020826 Description: nitric oxide synthase 2%2C inducible [Source:MGI Symbol;Acc:MGI:97361] Location: 11:78811613-78851080 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: macrophage Other: Innate Immune System Platelet homeostasis Peroxisomal protein import Pecam1 Gene Information Basic Information Ensembl ID: ENSMUSG00000020717 Description: platelet/endothelial cell adhesion molecule 1 [Source:MGI Symbol;Acc:MGI:97537] Location: 11:106545043-106641454 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell epithelial cell Other: Innate Immune System Cell surface interactions at the vascular wall Integrin cell surface interactions Ptprn2 Gene Information Basic Information Ensembl ID: ENSMUSG00000056553 Description: protein tyrosine phosphatase receptor type N polypeptide 2 [Source:MGI Symbol;Acc:MGI:107418] Location: 12:116449340-117240469 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Innate Immune System Retn Gene Information Basic Information Ensembl ID: ENSMUSG00000012705 Description: resistin [Source:MGI Symbol;Acc:MGI:1888506] Location: 8:3705770-3710110 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Sell Gene Information Basic Information Ensembl ID: ENSMUSG00000026581 Description: selectin%2C lymphocyte [Source:MGI Symbol;Acc:MGI:98279] Location: 1:163889551-163911750 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell natural killer cell Regulatory T cell Naive B cell Specialized T cell CD8+ T cell dendritic cell T cell myeloid progenitor cell CD4+ T cell developing T cell Other: Adaptive Immune System Innate Immune System Cell surface interactions at the vascular wall Snap25 Gene Information Basic Information Ensembl ID: ENSMUSG00000027273 Description: synaptosomal-associated protein 25 [Source:MGI Symbol;Acc:MGI:98331] Location: 2:136555373-136624348 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron endocrine cell Other: Cytokine Signaling in Immune system Innate Immune System Transmission across Chemical Synapses Tlr2 Gene Information Basic Information Ensembl ID: ENSMUSG00000027995 Description: toll-like receptor 2 [Source:MGI Symbol;Acc:MGI:1346060] Location: 3:83743579-83749074 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte leukocyte Other: Innate Immune System Tlr4 Gene Information Basic Information Ensembl ID: ENSMUSG00000039005 Description: toll-like receptor 4 [Source:MGI Symbol;Acc:MGI:96824] Location: 4:66745821-66848521 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte Other: Apoptosis Innate Immune System Cellular responses to stress Tlr7 Gene Information Basic Information Ensembl ID: ENSMUSG00000044583 Description: toll-like receptor 7 [Source:MGI Symbol;Acc:MGI:2176882] Location: X:166087925-166113554 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell Other: Innate Immune System Tlr9 Gene Information Basic Information Ensembl ID: ENSMUSG00000045322 Description: toll-like receptor 9 [Source:MGI Symbol;Acc:MGI:1932389] Location: 9:106099797-106104082 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Signaling by Receptor Tyrosine Kinases
Integration of energy metabolism Pathway Hierarchies & Genes Intracellular metabolism of fatty acids regulates insulin secretion (1 genes) Metabolism Integration of energy metabolism Regulation of insulin secretion Free fatty acids regulate insulin secretion Intracellular metabolism of fatty acids regulates insulin secretion 1 genes	Cd36 Gene Information Basic Information Ensembl ID: ENSMUSG00000002944 Description: CD36 molecule [Source:MGI Symbol;Acc:MGI:107899] Location: 5:17986688-18093799 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: macrophage Other: Adaptive Immune System Integration of energy metabolism Innate Immune System
Integrin cell surface interactions Pathway Hierarchies & Genes Integrin cell surface interactions (16 genes) Extracellular matrix organization Integrin cell surface interactions 16 genes	Cd44 Gene Information Basic Information Ensembl ID: ENSMUSG00000005087 Description: CD44 antigen [Source:MGI Symbol;Acc:MGI:88338] Location: 2:102641486-102732010 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell phagocyte monocyte granulocyte neutrophil macrophage progenitor cell Other: Cell surface interactions at the vascular wall Integrin cell surface interactions Innate Immune System Comp Gene Information Basic Information Ensembl ID: ENSMUSG00000031849 Description: cartilage oligomeric matrix protein [Source:MGI Symbol;Acc:MGI:88469] Location: 8:70826208-70834716 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stromal cell Other: Integrin cell surface interactions ECM proteoglycans Icam1 Gene Information Basic Information Ensembl ID: ENSMUSG00000037405 Description: intercellular adhesion molecule 1 [Source:MGI Symbol;Acc:MGI:96392] Location: 9:20927281-20940113 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stem cell pneumocyte Other: Adaptive Immune System Integrin cell surface interactions Itga1 Gene Information Basic Information Ensembl ID: ENSMUSG00000042284 Description: integrin alpha 1 [Source:MGI Symbol;Acc:MGI:96599] Location: 13:115089632-115238500 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell pericyte stellate cell epithelial cell mural cell Other: Integrin cell surface interactions Smooth Muscle Contraction Itga2 Gene Information Basic Information Ensembl ID: ENSMUSG00000015533 Description: integrin alpha 2 [Source:MGI Symbol;Acc:MGI:96600] Location: 13:114969617-115068636 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Specialized T cell Other: Integrin cell surface interactions Non-integrin membrane-ECM interactions ECM proteoglycans Itga6 Gene Information Basic Information Ensembl ID: ENSMUSG00000027111 Description: integrin alpha 6 [Source:MGI Symbol;Acc:MGI:96605] Location: 2:71575960-71688760 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell epithelial cell progenitor cell Other: Cell surface interactions at the vascular wall Integrin cell surface interactions Laminin interactions Itga8 Gene Information Basic Information Ensembl ID: ENSMUSG00000026768 Description: integrin alpha 8 [Source:MGI Symbol;Acc:MGI:109442] Location: 2:12111443-12306733 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast smooth muscle cell epithelial cell mesenchymal stem cell Other: Elastic fibre formation Integrin cell surface interactions ECM proteoglycans Itgae Gene Information Basic Information Ensembl ID: ENSMUSG00000005947 Description: integrin alpha E%2C epithelial-associated [Source:MGI Symbol;Acc:MGI:1298377] Location: 11:72981409-73038272 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell dendritic cell memory T cell innate lymphoid cell Other: Integrin cell surface interactions Itgal Gene Information Basic Information Ensembl ID: ENSMUSG00000030830 Description: integrin alpha L [Source:MGI Symbol;Acc:MGI:96606] Location: 7:126895432-126934310 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell CD4+ T cell CD8+ T cell monocyte Specialized T cell Other: Adaptive Immune System Innate Immune System Cell surface interactions at the vascular wall Itgam Gene Information Basic Information Ensembl ID: ENSMUSG00000030786 Description: integrin alpha M [Source:MGI Symbol;Acc:MGI:96607] Location: 7:127661812-127717663 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell phagocyte macrophage monocyte myeloid cell dendritic cell microglia myeloid derived suppressor cell immune cell Other: Innate Immune System Cell surface interactions at the vascular wall Integrin cell surface interactions Itgax Gene Information Basic Information Ensembl ID: ENSMUSG00000030789 Description: integrin alpha X [Source:MGI Symbol;Acc:MGI:96609] Location: 7:127728719-127749829 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell phagocyte macrophage dendritic cell Other: Innate Immune System Cell surface interactions at the vascular wall Integrin cell surface interactions Itgb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000025809 Description: integrin beta 1 (fibronectin receptor beta) [Source:MGI Symbol;Acc:MGI:96610] Location: 8:129412135-129459681 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell pericyte stellate cell stromal cell smooth muscle cell fibroblast muscle cell mural cell basal cell kidney cell Other: Laminin interactions Adaptive Immune System Elastic fibre formation Itgb3 Gene Information Basic Information Ensembl ID: ENSMUSG00000020689 Description: integrin beta 3 [Source:MGI Symbol;Acc:MGI:96612] Location: 11:104498826-104561302 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell stromal cell bone cell megakaryocyte Other: Elastic fibre formation Cell surface interactions at the vascular wall Integrin cell surface interactions Lum Gene Information Basic Information Ensembl ID: ENSMUSG00000036446 Description: lumican [Source:MGI Symbol;Acc:MGI:109347] Location: 10:97400990-97408565 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stellate cell stem cell stromal cell epithelial cell Other: Integrin cell surface interactions Metabolism of carbohydrates and carbohydrate derivatives Pecam1 Gene Information Basic Information Ensembl ID: ENSMUSG00000020717 Description: platelet/endothelial cell adhesion molecule 1 [Source:MGI Symbol;Acc:MGI:97537] Location: 11:106545043-106641454 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell epithelial cell Other: Innate Immune System Cell surface interactions at the vascular wall Integrin cell surface interactions Vwf Gene Information Basic Information Ensembl ID: ENSMUSG00000001930 Description: Von Willebrand factor [Source:MGI Symbol;Acc:MGI:98941] Location: 6:125523737-125663642 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell endocardial cell endodermal cell hematopoietic stem cell Other: Formation of Fibrin Clot (Clotting Cascade) Integrin cell surface interactions Integrin signaling
Integrin signaling Pathway Hierarchies & Genes p130Cas linkage to MAPK signaling for integrins (2 genes) Signal Transduction Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins 2 genes	Itgb3 Gene Information Basic Information Ensembl ID: ENSMUSG00000020689 Description: integrin beta 3 [Source:MGI Symbol;Acc:MGI:96612] Location: 11:104498826-104561302 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell stromal cell bone cell megakaryocyte Other: Elastic fibre formation Cell surface interactions at the vascular wall Integrin cell surface interactions Vwf Gene Information Basic Information Ensembl ID: ENSMUSG00000001930 Description: Von Willebrand factor [Source:MGI Symbol;Acc:MGI:98941] Location: 6:125523737-125663642 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell endocardial cell endodermal cell hematopoietic stem cell Other: Formation of Fibrin Clot (Clotting Cascade) Integrin cell surface interactions Integrin signaling
Intestinal absorption Pathway Hierarchies & Genes Intestinal hexose absorption (1 genes) Digestion and absorption Intestinal absorption Intestinal hexose absorption 1 genes	Slc5a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000011034 Description: solute carrier family 5 (sodium/glucose cotransporter)%2C member 1 [Source:MGI Symbol;Acc:MGI:107678] Location: 5:33261563-33320214 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: SLC-mediated transmembrane transport Intestinal absorption
Intracellular signaling by second messengers Pathway Hierarchies & Genes PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (9 genes) Signal Transduction Intracellular signaling by second messengers PIP3 activates AKT signaling Negative regulation of the PI3K/AKT network PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 9 genes	Areg Gene Information Basic Information Ensembl ID: ENSMUSG00000029378 Description: amphiregulin [Source:MGI Symbol;Acc:MGI:88068] Location: 5:91287458-91296291 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell innate lymphoid cell Other: Post-translational protein modification Membrane Trafficking MAPK family signaling cascades Cd19 Gene Information Basic Information Ensembl ID: ENSMUSG00000030724 Description: CD19 antigen [Source:MGI Symbol;Acc:MGI:88319] Location: 7:126007622-126014061 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Naive B cell Follicular B cell memory B cell Other: Adaptive Immune System Innate Immune System Intracellular signaling by second messengers Cd28 Gene Information Basic Information Ensembl ID: ENSMUSG00000026012 Description: CD28 antigen [Source:MGI Symbol;Acc:MGI:88327] Location: 1:60755959-60812518 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell Regulatory T cell CD4+ T cell Specialized T cell T cell Other: Adaptive Immune System Intracellular signaling by second messengers Cd80 Gene Information Basic Information Ensembl ID: ENSMUSG00000075122 Description: CD80 antigen [Source:MGI Symbol;Acc:MGI:101775] Location: 16:38275923-38316697 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Adaptive Immune System Intracellular signaling by second messengers Cd86 Gene Information Basic Information Ensembl ID: ENSMUSG00000022901 Description: CD86 antigen [Source:MGI Symbol;Acc:MGI:101773] Location: 16:36424231-36486443 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell Naive B cell phagocyte leukocyte Other: Adaptive Immune System Intracellular signaling by second messengers Egfr Gene Information Basic Information Ensembl ID: ENSMUSG00000020122 Description: epidermal growth factor receptor [Source:MGI Symbol;Acc:MGI:95294] Location: 11:16702203-16868158 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stromal cell pneumocyte mesenchymal cell Other: Signaling by NOTCH Membrane Trafficking Signaling by GPCR Il1rl1 Gene Information Basic Information Ensembl ID: ENSMUSG00000026069 Description: interleukin 1 receptor-like 1 [Source:MGI Symbol;Acc:MGI:98427] Location: 1:40468730-40504575 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell natural killer cell mast cell Other: Cytokine Signaling in Immune system Intracellular signaling by second messengers Kit Gene Information Basic Information Ensembl ID: ENSMUSG00000005672 Description: KIT proto-oncogene receptor tyrosine kinase [Source:MGI Symbol;Acc:MGI:96677] Location: 5:75735576-75817382 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell natural killer cell interneuron epithelial cell intercalated cell tuft cell mast cell innate lymphoid cell hematopoietic stem cell progenitor cell dendritic cell Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Kl Gene Information Basic Information Ensembl ID: ENSMUSG00000058488 Description: klotho [Source:MGI Symbol;Acc:MGI:1101771] Location: 5:150876072-150917282 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases
Ion channel transport Pathway Hierarchies & Genes Stimuli-sensing channels (7 genes) Transport of small molecules Ion channel transport 2 genes Stimuli-sensing channels 5 genes	Atp6v0d2 Gene Information Basic Information Ensembl ID: ENSMUSG00000028238 Description: ATPase%2C H+ transporting%2C lysosomal V0 subunit D2 [Source:MGI Symbol;Acc:MGI:1924415] Location: 4:19876841-19922605 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: kidney cell phagocyte epithelial cell Other: Innate Immune System Cellular responses to stress Signaling by Receptor Tyrosine Kinases Atp6v1b1 Gene Information Basic Information Ensembl ID: ENSMUSG00000006269 Description: ATPase%2C H+ transporting%2C lysosomal V1 subunit B1 [Source:MGI Symbol;Acc:MGI:103285] Location: 6:83719972-83735837 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: kidney cell intercalated cell epithelial cell Other: Innate Immune System Cellular responses to stress Signaling by Receptor Tyrosine Kinases Clcnka Gene Information Basic Information Ensembl ID: ENSMUSG00000033770 Description: chloride channel%2C voltage-sensitive Ka [Source:MGI Symbol;Acc:MGI:1329026] Location: 4:141111921-141126035 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Ion channel transport Clcnkb Gene Information Basic Information Ensembl ID: ENSMUSG00000006216 Description: chloride channel%2C voltage-sensitive Kb [Source:MGI Symbol;Acc:MGI:1930643] Location: 4:141131664-141143325 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Ion channel transport Fxyd6 Gene Information Basic Information Ensembl ID: ENSMUSG00000066705 Description: FXYD domain-containing ion transport regulator 6 [Source:MGI Symbol;Acc:MGI:1890226] Location: 9:45281483-45307457 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell interneuron glial cell enteroendocrine cell dendritic cell Other: Cardiac conduction Ion channel transport Pln Gene Information Basic Information Ensembl ID: ENSMUSG00000038583 Description: phospholamban [Source:MGI Symbol;Acc:MGI:97622] Location: 10:53213763-53222083 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: cardiomyocyte smooth muscle cell Other: Cardiac conduction Ion channel transport Trdn Gene Information Basic Information Ensembl ID: ENSMUSG00000019787 Description: triadin [Source:MGI Symbol;Acc:MGI:1924007] Location: 10:32956550-33352705 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: cardiomyocyte skeletal muscle cell fibroblast Other: Cardiac conduction Ion channel transport
Iron uptake and transport Pathway Hierarchies & Genes Transferrin endocytosis and recycling (4 genes) Transport of small molecules Iron uptake and transport 1 genes Transferrin endocytosis and recycling 3 genes	Atp6v0d2 Gene Information Basic Information Ensembl ID: ENSMUSG00000028238 Description: ATPase%2C H+ transporting%2C lysosomal V0 subunit D2 [Source:MGI Symbol;Acc:MGI:1924415] Location: 4:19876841-19922605 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: kidney cell phagocyte epithelial cell Other: Innate Immune System Cellular responses to stress Signaling by Receptor Tyrosine Kinases Atp6v1b1 Gene Information Basic Information Ensembl ID: ENSMUSG00000006269 Description: ATPase%2C H+ transporting%2C lysosomal V1 subunit B1 [Source:MGI Symbol;Acc:MGI:103285] Location: 6:83719972-83735837 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: kidney cell intercalated cell epithelial cell Other: Innate Immune System Cellular responses to stress Signaling by Receptor Tyrosine Kinases Cp Gene Information Basic Information Ensembl ID: ENSMUSG00000003617 Description: ceruloplasmin [Source:MGI Symbol;Acc:MGI:88476] Location: 3:20011218-20063309 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell fibroblast stellate cell pericyte stem cell stromal cell basal cell glial cell epithelial cell Other: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) SLC-mediated transmembrane transport Post-translational protein modification Tfrc Gene Information Basic Information Ensembl ID: ENSMUSG00000022797 Description: transferrin receptor [Source:MGI Symbol;Acc:MGI:98822] Location: 16:32427738-32451612 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: progenitor cell erythroid progenitor cell erythroblast erythroid cell T cell Other: Membrane Trafficking Iron uptake and transport Signaling by Rho GTPases, Miro GTPases and RHOBTB3
Keratinization Pathway Hierarchies & Genes Formation of the cornified envelope (5 genes) Developmental Biology Keratinization Formation of the cornified envelope 5 genes	Dsc3 Gene Information Basic Information Ensembl ID: ENSMUSG00000059898 Description: desmocollin 3 [Source:MGI Symbol;Acc:MGI:1194993] Location: 18:20093987-20135408 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast epithelial cell Other: Keratinization Krt13 Gene Information Basic Information Ensembl ID: ENSMUSG00000044041 Description: keratin 13 [Source:MGI Symbol;Acc:MGI:101925] Location: 11:100008153-100012392 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell basal cell Other: Keratinization Krt19 Gene Information Basic Information Ensembl ID: ENSMUSG00000020911 Description: keratin 19 [Source:MGI Symbol;Acc:MGI:96693] Location: 11:100031636-100039491 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell stem cell fibroblast pancreatic cell ductal cell Other: Keratinization Krt79 Gene Information Basic Information Ensembl ID: ENSMUSG00000061397 Description: keratin 79 [Source:MGI Symbol;Acc:MGI:2385030] Location: 15:101837767-101848759 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: macrophage epithelial cell Other: Keratinization Krt8 Gene Information Basic Information Ensembl ID: ENSMUSG00000049382 Description: keratin 8 [Source:MGI Symbol;Acc:MGI:96705] Location: 15:101905133-101912917 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell stem cell fibroblast tuft cell Other: Keratinization
Laminin interactions Pathway Hierarchies & Genes Laminin interactions (2 genes) Extracellular matrix organization Laminin interactions 2 genes	Itga6 Gene Information Basic Information Ensembl ID: ENSMUSG00000027111 Description: integrin alpha 6 [Source:MGI Symbol;Acc:MGI:96605] Location: 2:71575960-71688760 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell epithelial cell progenitor cell Other: Cell surface interactions at the vascular wall Integrin cell surface interactions Laminin interactions Itgb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000025809 Description: integrin beta 1 (fibronectin receptor beta) [Source:MGI Symbol;Acc:MGI:96610] Location: 8:129412135-129459681 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell pericyte stellate cell stromal cell smooth muscle cell fibroblast muscle cell mural cell basal cell kidney cell Other: Laminin interactions Adaptive Immune System Elastic fibre formation
MAPK family signaling cascades Pathway Hierarchies & Genes MAP2K and MAPK activation (2 genes) Signal Transduction MAPK family signaling cascades MAPK1/MAPK3 signaling RAF/MAP kinase cascade MAP2K and MAPK activation 2 genes MAPK3 (ERK1) activation (2 genes) Signal Transduction MAPK family signaling cascades MAPK1/MAPK3 signaling RAF-independent MAPK1/3 activation MAPK3 (ERK1) activation 2 genes RAF/MAP kinase cascade (6 genes) Signal Transduction MAPK family signaling cascades MAPK1/MAPK3 signaling RAF/MAP kinase cascade 6 genes	Areg Gene Information Basic Information Ensembl ID: ENSMUSG00000029378 Description: amphiregulin [Source:MGI Symbol;Acc:MGI:88068] Location: 5:91287458-91296291 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell innate lymphoid cell Other: Post-translational protein modification Membrane Trafficking MAPK family signaling cascades Egfr Gene Information Basic Information Ensembl ID: ENSMUSG00000020122 Description: epidermal growth factor receptor [Source:MGI Symbol;Acc:MGI:95294] Location: 11:16702203-16868158 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stromal cell pneumocyte mesenchymal cell Other: Signaling by NOTCH Membrane Trafficking Signaling by GPCR Il2ra Gene Information Basic Information Ensembl ID: ENSMUSG00000026770 Description: interleukin 2 receptor%2C alpha chain [Source:MGI Symbol;Acc:MGI:96549] Location: 2:11647618-11698004 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Regulatory T cell T cell CD8+ T cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades Il2rb Gene Information Basic Information Ensembl ID: ENSMUSG00000068227 Description: interleukin 2 receptor%2C beta chain [Source:MGI Symbol;Acc:MGI:96550] Location: 15:78363456-78379471 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell developing T cell Specialized T cell Other: Cytokine Signaling in Immune system MAPK family signaling cascades Il6 Gene Information Basic Information Ensembl ID: ENSMUSG00000025746 Description: interleukin 6 [Source:MGI Symbol;Acc:MGI:96559] Location: 5:30218112-30224979 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stem cell endothelial cell basophil eosinophil mural cell Other: Cytokine Signaling in Immune system Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MAPK family signaling cascades Il6ra Gene Information Basic Information Ensembl ID: ENSMUSG00000027947 Description: interleukin 6 receptor%2C alpha [Source:MGI Symbol;Acc:MGI:105304] Location: 3:89771366-89820503 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte monocyte Other: Cytokine Signaling in Immune system MAPK family signaling cascades Itgb3 Gene Information Basic Information Ensembl ID: ENSMUSG00000020689 Description: integrin beta 3 [Source:MGI Symbol;Acc:MGI:96612] Location: 11:104498826-104561302 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell stromal cell bone cell megakaryocyte Other: Elastic fibre formation Cell surface interactions at the vascular wall Integrin cell surface interactions Kit Gene Information Basic Information Ensembl ID: ENSMUSG00000005672 Description: KIT proto-oncogene receptor tyrosine kinase [Source:MGI Symbol;Acc:MGI:96677] Location: 5:75735576-75817382 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell natural killer cell interneuron epithelial cell intercalated cell tuft cell mast cell innate lymphoid cell hematopoietic stem cell progenitor cell dendritic cell Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Kl Gene Information Basic Information Ensembl ID: ENSMUSG00000058488 Description: klotho [Source:MGI Symbol;Acc:MGI:1101771] Location: 5:150876072-150917282 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Vwf Gene Information Basic Information Ensembl ID: ENSMUSG00000001930 Description: Von Willebrand factor [Source:MGI Symbol;Acc:MGI:98941] Location: 6:125523737-125663642 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell endocardial cell endodermal cell hematopoietic stem cell Other: Formation of Fibrin Clot (Clotting Cascade) Integrin cell surface interactions Integrin signaling
MITF-M-regulated melanocyte development Pathway Hierarchies & Genes Transcriptional and post-translational regulation of MITF-M expression and activity (1 genes) Developmental Biology MITF-M-regulated melanocyte development Transcriptional and post-translational regulation of MITF-M expression and activity 1 genes	Kit Gene Information Basic Information Ensembl ID: ENSMUSG00000005672 Description: KIT proto-oncogene receptor tyrosine kinase [Source:MGI Symbol;Acc:MGI:96677] Location: 5:75735576-75817382 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell natural killer cell interneuron epithelial cell intercalated cell tuft cell mast cell innate lymphoid cell hematopoietic stem cell progenitor cell dendritic cell Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases
Macroautophagy Pathway Hierarchies & Genes Aggrephagy (1 genes) Autophagy Macroautophagy Selective autophagy Aggrephagy 1 genes	Tubb3 Gene Information Basic Information Ensembl ID: ENSMUSG00000062380 Description: tubulin%2C beta 3 class III [Source:MGI Symbol;Acc:MGI:107813] Location: 8:124138163-124148754 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell neuron motor neuron Other: Cytokine Signaling in Immune system Adaptive Immune System Macroautophagy
Membrane Trafficking Pathway Hierarchies & Genes COPI-dependent Golgi-to-ER retrograde traffic (1 genes) Vesicle-mediated transport Membrane Trafficking Gap junction trafficking and regulation Gap junction trafficking Gap junction assembly Transport of connexons to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane ER to Golgi Anterograde Transport COPI-mediated anterograde transport Intra-Golgi and retrograde Golgi-to-ER traffic Golgi-to-ER retrograde transport COPI-dependent Golgi-to-ER retrograde traffic 1 genes Cargo recognition for clathrin-mediated endocytosis (1 genes) Vesicle-mediated transport Membrane Trafficking trans-Golgi Network Vesicle Budding Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis Cargo recognition for clathrin-mediated endocytosis 1 genes Cargo recognition for clathrin-mediated endocytosis (1 genes) Vesicle-mediated transport Membrane Trafficking ER to Golgi Anterograde Transport COPII-mediated vesicle transport Clathrin-mediated endocytosis Cargo recognition for clathrin-mediated endocytosis 1 genes Gap junction assembly (1 genes) Vesicle-mediated transport Membrane Trafficking Gap junction trafficking and regulation Gap junction trafficking Gap junction assembly 1 genes Cargo recognition for clathrin-mediated endocytosis (5 genes) Vesicle-mediated transport Membrane Trafficking Clathrin-mediated endocytosis Cargo recognition for clathrin-mediated endocytosis 5 genes	Areg Gene Information Basic Information Ensembl ID: ENSMUSG00000029378 Description: amphiregulin [Source:MGI Symbol;Acc:MGI:88068] Location: 5:91287458-91296291 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell innate lymphoid cell Other: Post-translational protein modification Membrane Trafficking MAPK family signaling cascades Cd3d Gene Information Basic Information Ensembl ID: ENSMUSG00000032094 Description: CD3 antigen%2C delta polypeptide [Source:MGI Symbol;Acc:MGI:88331] Location: 9:44893084-44898637 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell CD8+ T cell developing T cell Specialized T cell Other: Adaptive Immune System Membrane Trafficking Cd4 Gene Information Basic Information Ensembl ID: ENSMUSG00000023274 Description: CD4 antigen [Source:MGI Symbol;Acc:MGI:88335] Location: 6:124841655-124865184 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: developing T cell Regulatory T cell CD4+ T cell dendritic cell T cell Other: Cytokine Signaling in Immune system Adaptive Immune System Innate Immune System Egfr Gene Information Basic Information Ensembl ID: ENSMUSG00000020122 Description: epidermal growth factor receptor [Source:MGI Symbol;Acc:MGI:95294] Location: 11:16702203-16868158 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stromal cell pneumocyte mesenchymal cell Other: Signaling by NOTCH Membrane Trafficking Signaling by GPCR Gjb4 Gene Information Basic Information Ensembl ID: ENSMUSG00000046623 Description: gap junction protein%2C beta 4 [Source:MGI Symbol;Acc:MGI:95722] Location: 4:127244879-127247874 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stem cell Other: Membrane Trafficking Il7r Gene Information Basic Information Ensembl ID: ENSMUSG00000003882 Description: interleukin 7 receptor [Source:MGI Symbol;Acc:MGI:96562] Location: 15:9505874-9530262 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell CD8+ T cell dendritic cell developing T cell Regulatory T cell mast cell memory T cell effector T cell innate lymphoid cell Other: Cytokine Signaling in Immune system Membrane Trafficking Lrp2 Gene Information Basic Information Ensembl ID: ENSMUSG00000027070 Description: low density lipoprotein receptor-related protein 2 [Source:MGI Symbol;Acc:MGI:95794] Location: 2:69254684-69416409 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Metabolism of vitamins and cofactors Membrane Trafficking Visual phototransduction Tfrc Gene Information Basic Information Ensembl ID: ENSMUSG00000022797 Description: transferrin receptor [Source:MGI Symbol;Acc:MGI:98822] Location: 16:32427738-32451612 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: progenitor cell erythroid progenitor cell erythroblast erythroid cell T cell Other: Membrane Trafficking Iron uptake and transport Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Tubb3 Gene Information Basic Information Ensembl ID: ENSMUSG00000062380 Description: tubulin%2C beta 3 class III [Source:MGI Symbol;Acc:MGI:107813] Location: 8:124138163-124148754 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell neuron motor neuron Other: Cytokine Signaling in Immune system Adaptive Immune System Macroautophagy
Metabolism of amino acids and derivatives Pathway Hierarchies & Genes Thyroxine biosynthesis (1 genes) Metabolism Metabolism of amino acids and derivatives Metabolism of amine-derived hormones Thyroxine biosynthesis 1 genes Tryptophan catabolism (1 genes) Metabolism Metabolism of amino acids and derivatives Lysine catabolism Tryptophan catabolism 1 genes Tyrosine catabolism (1 genes) Metabolism Metabolism of amino acids and derivatives Phenylalanine and tyrosine metabolism Tyrosine catabolism 1 genes Creatine metabolism (1 genes) Metabolism Metabolism of amino acids and derivatives Creatine metabolism 1 genes Glyoxylate metabolism and glycine degradation (1 genes) Metabolism Metabolism of amino acids and derivatives Glyoxylate metabolism and glycine degradation 1 genes Urea cycle (1 genes) Metabolism Metabolism of amino acids and derivatives Urea cycle 1 genes	Aadat Gene Information Basic Information Ensembl ID: ENSMUSG00000057228 Description: aminoadipate aminotransferase [Source:MGI Symbol;Acc:MGI:1345167] Location: 8:60958966-60998711 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Metabolism of amino acids and derivatives Arg1 Gene Information Basic Information Ensembl ID: ENSMUSG00000019987 Description: arginase%2C liver [Source:MGI Symbol;Acc:MGI:88070] Location: 10:24791119-24803382 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Metabolism of amino acids and derivatives Dao Gene Information Basic Information Ensembl ID: ENSMUSG00000042096 Description: D-amino acid oxidase [Source:MGI Symbol;Acc:MGI:94859] Location: 5:114141764-114163743 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Metabolism of amino acids and derivatives Peroxisomal protein import Gatm Gene Information Basic Information Ensembl ID: ENSMUSG00000027199 Description: glycine amidinotransferase (L-arginine:glycine amidinotransferase) [Source:MGI Symbol;Acc:MGI:1914342] Location: 2:122424948-122441784 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Metabolism of amino acids and derivatives Iyd Gene Information Basic Information Ensembl ID: ENSMUSG00000019762 Description: iodotyrosine deiodinase [Source:MGI Symbol;Acc:MGI:1917587] Location: 10:3490240-3504877 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Metabolism of amino acids and derivatives Tat Gene Information Basic Information Ensembl ID: ENSMUSG00000001670 Description: tyrosine aminotransferase [Source:MGI Symbol;Acc:MGI:98487] Location: 8:110717069-110726435 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Metabolism of amino acids and derivatives
Metabolism of carbohydrates and carbohydrate derivatives Pathway Hierarchies & Genes HS-GAG biosynthesis (1 genes) Metabolism Metabolism of carbohydrates and carbohydrate derivatives Glycosaminoglycan metabolism Heparan sulfate/heparin (HS-GAG) metabolism HS-GAG biosynthesis 1 genes Hyaluronan degradation (2 genes) Metabolism Metabolism of carbohydrates and carbohydrate derivatives Glycosaminoglycan metabolism Hyaluronan metabolism Hyaluronan degradation 2 genes Keratan sulfate biosynthesis (2 genes) Metabolism Metabolism of carbohydrates and carbohydrate derivatives Glycosaminoglycan metabolism Keratan sulfate/keratin metabolism Keratan sulfate biosynthesis 2 genes Glycogen breakdown (glycogenolysis) (1 genes) Metabolism Metabolism of carbohydrates and carbohydrate derivatives Glycogen metabolism Glycogen breakdown (glycogenolysis) 1 genes Lewis blood group biosynthesis (1 genes) Metabolism Metabolism of carbohydrates and carbohydrate derivatives Blood group systems biosynthesis Lewis blood group biosynthesis 1 genes	Acan Gene Information Basic Information Ensembl ID: ENSMUSG00000030607 Description: aggrecan [Source:MGI Symbol;Acc:MGI:99602] Location: 7:78703231-78764847 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stromal cell smooth muscle cell osteoblast chondrocyte Other: Degradation of the extracellular matrix ECM proteoglycans Metabolism of carbohydrates and carbohydrate derivatives B4galnt2 Gene Information Basic Information Ensembl ID: ENSMUSG00000013418 Description: beta-1%2C4-N-acetyl-galactosaminyl transferase 2 [Source:MGI Symbol;Acc:MGI:1342058] Location: 11:95756769-95805717 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Post-translational protein modification Metabolism of carbohydrates and carbohydrate derivatives Cd44 Gene Information Basic Information Ensembl ID: ENSMUSG00000005087 Description: CD44 antigen [Source:MGI Symbol;Acc:MGI:88338] Location: 2:102641486-102732010 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell phagocyte monocyte granulocyte neutrophil macrophage progenitor cell Other: Cell surface interactions at the vascular wall Integrin cell surface interactions Innate Immune System Lum Gene Information Basic Information Ensembl ID: ENSMUSG00000036446 Description: lumican [Source:MGI Symbol;Acc:MGI:109347] Location: 10:97400990-97408565 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stellate cell stem cell stromal cell epithelial cell Other: Integrin cell surface interactions Metabolism of carbohydrates and carbohydrate derivatives Lyve1 Gene Information Basic Information Ensembl ID: ENSMUSG00000030787 Description: lymphatic vessel endothelial hyaluronan receptor 1 [Source:MGI Symbol;Acc:MGI:2136348] Location: 7:110449814-110462446 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell phagocyte antigen presenting cell macrophage immune cell lymphocyte Other: Metabolism of carbohydrates and carbohydrate derivatives Pygm Gene Information Basic Information Ensembl ID: ENSMUSG00000032648 Description: muscle glycogen phosphorylase [Source:MGI Symbol;Acc:MGI:97830] Location: 19:6434429-6448489 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: skeletal muscle cell Other: Metabolism of carbohydrates and carbohydrate derivatives Sdc1 Gene Information Basic Information Ensembl ID: ENSMUSG00000020592 Description: syndecan 1 [Source:MGI Symbol;Acc:MGI:1349162] Location: 12:8821323-8843715 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte stem cell epithelial cell pneumocyte Naive B cell basal cell plasma cell leukocyte T cell Specialized T cell Other: Cytokine Signaling in Immune system Metabolism of vitamins and cofactors Cell surface interactions at the vascular wall
Metabolism of lipids Pathway Hierarchies & Genes Biosynthesis of Lipoxins (LX) (1 genes) Metabolism Metabolism of lipids Fatty acid metabolism Arachidonate metabolism Synthesis of 5-eicosatetraenoic acids Biosynthesis of specialized proresolving mediators (SPMs) Biosynthesis of Lipoxins (LX) 1 genes Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (1 genes) Metabolism Metabolism of lipids Metabolism of steroids Bile acid and bile salt metabolism Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 1 genes Acyl chain remodeling of DAG and TAG (1 genes) Metabolism Metabolism of lipids Phospholipid metabolism Glycerophospholipid biosynthesis Acyl chain remodeling of DAG and TAG 1 genes Acyl chain remodelling of PC (1 genes) Metabolism Metabolism of lipids Phospholipid metabolism Glycerophospholipid biosynthesis Acyl chain remodelling of PC 1 genes Biosynthesis of D-series resolvins (1 genes) Metabolism Metabolism of lipids Biosynthesis of specialized proresolving mediators (SPMs) Biosynthesis of DHA-derived SPMs Biosynthesis of D-series resolvins 1 genes Pregnenolone biosynthesis (1 genes) Metabolism Metabolism of lipids Metabolism of steroids Metabolism of steroid hormones Pregnenolone biosynthesis 1 genes Recycling of bile acids and salts (1 genes) Metabolism Metabolism of lipids Metabolism of steroids Bile acid and bile salt metabolism Recycling of bile acids and salts 1 genes Mitochondrial Fatty Acid Beta-Oxidation (1 genes) Metabolism Metabolism of lipids Fatty acid metabolism Mitochondrial Fatty Acid Beta-Oxidation 1 genes Synthesis of Ketone Bodies (1 genes) Metabolism Metabolism of lipids Ketone body metabolism Synthesis of Ketone Bodies 1 genes	Abcb11 Gene Information Basic Information Ensembl ID: ENSMUSG00000027048 Description: ATP-binding cassette%2C sub-family B member 11 [Source:MGI Symbol;Acc:MGI:1351619] Location: 2:69068626-69172958 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: hepatocyte Other: Metabolism of lipids Alox5ap Gene Information Basic Information Ensembl ID: ENSMUSG00000060063 Description: arachidonate 5-lipoxygenase activating protein [Source:MGI Symbol;Acc:MGI:107505] Location: 5:149201577-149224963 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell dendritic cell phagocyte tuft cell granulocyte eosinophil monocyte myeloid cell T cell macrophage leukocyte Other: Metabolism of lipids Cyp11a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000032323 Description: cytochrome P450%2C family 11%2C subfamily a%2C polypeptide 1 [Source:MGI Symbol;Acc:MGI:88582] Location: 9:57913694-57934306 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Biological oxidations Metabolism of lipids Hmgcs2 Gene Information Basic Information Ensembl ID: ENSMUSG00000027875 Description: 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 [Source:MGI Symbol;Acc:MGI:101939] Location: 3:98187751-98218054 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Metabolism of lipids Mitochondrial protein degradation Hpgd Gene Information Basic Information Ensembl ID: ENSMUSG00000031613 Description: hydroxyprostaglandin dehydrogenase 15 (NAD) [Source:MGI Symbol;Acc:MGI:108085] Location: 8:56747620-56774078 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell phagocyte epithelial cell antigen presenting cell monocyte Other: Metabolism of lipids Mgll Gene Information Basic Information Ensembl ID: ENSMUSG00000033174 Description: monoglyceride lipase [Source:MGI Symbol;Acc:MGI:1346042] Location: 6:88701394-88805342 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell pancreatic cell smooth muscle cell astrocyte Other: Signaling by GPCR Metabolism of lipids Platelet activation, signaling and aggregation Plbd1 Gene Information Basic Information Ensembl ID: ENSMUSG00000030214 Description: phospholipase B domain containing 1 [Source:MGI Symbol;Acc:MGI:1914107] Location: 6:136589068-136638926 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell phagocyte monocyte myeloid cell leukocyte Other: Metabolism of lipids Slc10a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000021135 Description: solute carrier family 10 (sodium/bile acid cotransporter family)%2C member 1 [Source:MGI Symbol;Acc:MGI:97379] Location: 12:80999957-81015479 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Metabolism of lipids Them5 Gene Information Basic Information Ensembl ID: ENSMUSG00000028148 Description: thioesterase superfamily member 5 [Source:MGI Symbol;Acc:MGI:1913448] Location: 3:94249406-94254659 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Metabolism of lipids
Metabolism of nitric oxide: NOS3 activation and regulation Pathway Hierarchies & Genes NOSTRIN mediated eNOS trafficking (1 genes) Metabolism Metabolism of nitric oxide: NOS3 activation and regulation eNOS activation NOSTRIN mediated eNOS trafficking 1 genes	Cav1 Gene Information Basic Information Ensembl ID: ENSMUSG00000007655 Description: caveolin 1%2C caveolae protein [Source:MGI Symbol;Acc:MGI:102709] Location: 6:17306334-17341451 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by WNT Metabolism of nitric oxide: NOS3 activation and regulation Cell surface interactions at the vascular wall
Metabolism of nucleotides Pathway Hierarchies & Genes Phosphate bond hydrolysis by NTPDase proteins (1 genes) Metabolism Metabolism of nucleotides Nucleotide catabolism Phosphate bond hydrolysis by NTPDase proteins 1 genes Pyrimidine catabolism (1 genes) Metabolism Metabolism of nucleotides Nucleotide catabolism Pyrimidine catabolism 1 genes	Entpd1 Gene Information Basic Information Ensembl ID: ENSMUSG00000048120 Description: ectonucleoside triphosphate diphosphohydrolase 1 [Source:MGI Symbol;Acc:MGI:102805] Location: 19:40600810-40730046 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell endothelial cell phagocyte microglia Other: Metabolism of nucleotides Nt5e Gene Information Basic Information Ensembl ID: ENSMUSG00000032420 Description: 5' nucleotidase%2C ecto [Source:MGI Symbol;Acc:MGI:99782] Location: 9:88209250-88254145 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stromal cell photoreceptor cell pericyte stem cell CD4+ T cell Other: Metabolism of nucleotides Metabolism of vitamins and cofactors
Metabolism of porphyrins Pathway Hierarchies & Genes Heme biosynthesis (2 genes) Metabolism Metabolism of porphyrins Heme biosynthesis 2 genes	Fech Gene Information Basic Information Ensembl ID: ENSMUSG00000024588 Description: ferrochelatase [Source:MGI Symbol;Acc:MGI:95513] Location: 18:64585985-64623322 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: erythroblast Other: Metabolism of porphyrins Mitochondrial protein degradation Hmbs Gene Information Basic Information Ensembl ID: ENSMUSG00000032126 Description: hydroxymethylbilane synthase [Source:MGI Symbol;Acc:MGI:96112] Location: 9:44247636-44255525 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: erythrocyte hematopoietic progenitor cell erythroblast Other: Metabolism of porphyrins
Metabolism of vitamins and cofactors Pathway Hierarchies & Genes Metabolism of fat-soluble vitamins (1 genes) Metabolism Metabolism of vitamins and cofactors Metabolism of water-soluble vitamins and cofactors Cobalamin (Cbl, vitamin B12) transport and metabolism Transport of RCbl within the body Metabolism of fat-soluble vitamins 1 genes Nicotinate metabolism (3 genes) Metabolism Metabolism of vitamins and cofactors Metabolism of water-soluble vitamins and cofactors Nicotinate metabolism 3 genes Metabolism of fat-soluble vitamins (2 genes) Metabolism Metabolism of vitamins and cofactors Metabolism of fat-soluble vitamins 2 genes	Bst1 Gene Information Basic Information Ensembl ID: ENSMUSG00000029082 Description: bone marrow stromal cell antigen 1 [Source:MGI Symbol;Acc:MGI:105370] Location: 5:43976227-44001328 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell macrophage Other: Innate Immune System Metabolism of vitamins and cofactors Post-translational protein modification Cd38 Gene Information Basic Information Ensembl ID: ENSMUSG00000029084 Description: CD38 antigen [Source:MGI Symbol;Acc:MGI:107474] Location: 5:44025895-44069717 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell memory B cell Naive B cell Other: Metabolism of vitamins and cofactors Lrp2 Gene Information Basic Information Ensembl ID: ENSMUSG00000027070 Description: low density lipoprotein receptor-related protein 2 [Source:MGI Symbol;Acc:MGI:95794] Location: 2:69254684-69416409 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Metabolism of vitamins and cofactors Membrane Trafficking Visual phototransduction Nt5e Gene Information Basic Information Ensembl ID: ENSMUSG00000032420 Description: 5' nucleotidase%2C ecto [Source:MGI Symbol;Acc:MGI:99782] Location: 9:88209250-88254145 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stromal cell photoreceptor cell pericyte stem cell CD4+ T cell Other: Metabolism of nucleotides Metabolism of vitamins and cofactors Rbp1 Gene Information Basic Information Ensembl ID: ENSMUSG00000046402 Description: retinol binding protein 1%2C cellular [Source:MGI Symbol;Acc:MGI:97876] Location: 9:98305014-98328628 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell fibroblast stellate cell stem cell glial cell epithelial cell Other: Metabolism of vitamins and cofactors Visual phototransduction Sdc1 Gene Information Basic Information Ensembl ID: ENSMUSG00000020592 Description: syndecan 1 [Source:MGI Symbol;Acc:MGI:1349162] Location: 12:8821323-8843715 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte stem cell epithelial cell pneumocyte Naive B cell basal cell plasma cell leukocyte T cell Specialized T cell Other: Cytokine Signaling in Immune system Metabolism of vitamins and cofactors Cell surface interactions at the vascular wall
Mitochondrial protein degradation Pathway Hierarchies & Genes Mitochondrial protein degradation (3 genes) Metabolism of proteins Mitochondrial protein degradation 3 genes	Aldh1b1 Gene Information Basic Information Ensembl ID: ENSMUSG00000035561 Description: aldehyde dehydrogenase 1 family%2C member B1 [Source:MGI Symbol;Acc:MGI:1919785] Location: 4:45799022-45804604 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Biological oxidations Mitochondrial protein degradation Fech Gene Information Basic Information Ensembl ID: ENSMUSG00000024588 Description: ferrochelatase [Source:MGI Symbol;Acc:MGI:95513] Location: 18:64585985-64623322 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: erythroblast Other: Metabolism of porphyrins Mitochondrial protein degradation Hmgcs2 Gene Information Basic Information Ensembl ID: ENSMUSG00000027875 Description: 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 [Source:MGI Symbol;Acc:MGI:101939] Location: 3:98187751-98218054 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Metabolism of lipids Mitochondrial protein degradation
Myogenesis Pathway Hierarchies & Genes Myogenesis (1 genes) Developmental Biology Myogenesis 1 genes	Myf6 Gene Information Basic Information Ensembl ID: ENSMUSG00000035923 Description: myogenic factor 6 [Source:MGI Symbol;Acc:MGI:97253] Location: 10:107328714-107330598 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Myogenesis
Nervous system development Pathway Hierarchies & Genes EPH-ephrin mediated repulsion of cells (1 genes) Developmental Biology Nervous system development Axon guidance EPH-Ephrin signaling EPH-ephrin mediated repulsion of cells 1 genes Recycling pathway of L1 (1 genes) Developmental Biology Nervous system development Axon guidance L1CAM interactions Recycling pathway of L1 1 genes Sema3A PAK dependent Axon repulsion (1 genes) Developmental Biology Nervous system development Axon guidance Semaphorin interactions Sema3A PAK dependent Axon repulsion 1 genes Signal transduction by L1 (3 genes) Developmental Biology Nervous system development Axon guidance L1CAM interactions Signal transduction by L1 3 genes L1CAM interactions (1 genes) Developmental Biology Nervous system development Axon guidance L1CAM interactions 1 genes Signaling by ROBO receptors (1 genes) Developmental Biology Nervous system development Axon guidance Signaling by ROBO receptors 1 genes	Cxcr4 Gene Information Basic Information Ensembl ID: ENSMUSG00000045382 Description: C-X-C motif chemokine receptor 4 [Source:MGI Symbol;Acc:MGI:109563] Location: 1:128515936-128520030 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell endothelial cell mast cell monocyte eosinophil progenitor cell Other: Signaling by GPCR Nervous system development Egfr Gene Information Basic Information Ensembl ID: ENSMUSG00000020122 Description: epidermal growth factor receptor [Source:MGI Symbol;Acc:MGI:95294] Location: 11:16702203-16868158 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stromal cell pneumocyte mesenchymal cell Other: Signaling by NOTCH Membrane Trafficking Signaling by GPCR Gap43 Gene Information Basic Information Ensembl ID: ENSMUSG00000047261 Description: growth associated protein 43 [Source:MGI Symbol;Acc:MGI:95639] Location: 16:42068805-42161014 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte glial cell neuron motor neuron cajal-retzius cell Other: Nervous system development Itgb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000025809 Description: integrin beta 1 (fibronectin receptor beta) [Source:MGI Symbol;Acc:MGI:96610] Location: 8:129412135-129459681 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell pericyte stellate cell stromal cell smooth muscle cell fibroblast muscle cell mural cell basal cell kidney cell Other: Laminin interactions Adaptive Immune System Elastic fibre formation Itgb3 Gene Information Basic Information Ensembl ID: ENSMUSG00000020689 Description: integrin beta 3 [Source:MGI Symbol;Acc:MGI:96612] Location: 11:104498826-104561302 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell stromal cell bone cell megakaryocyte Other: Elastic fibre formation Cell surface interactions at the vascular wall Integrin cell surface interactions Mmp9 Gene Information Basic Information Ensembl ID: ENSMUSG00000017737 Description: matrix metallopeptidase 9 [Source:MGI Symbol;Acc:MGI:97011] Location: 2:164782700-164797770 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell bone cell granulocyte monocyte Other: Degradation of the extracellular matrix Collagen formation Innate Immune System Nrp1 Gene Information Basic Information Ensembl ID: ENSMUSG00000025810 Description: neuropilin 1 [Source:MGI Symbol;Acc:MGI:106206] Location: 8:129085085-129229844 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Regulatory T cell Other: Signaling by Receptor Tyrosine Kinases Nervous system development Tubb3 Gene Information Basic Information Ensembl ID: ENSMUSG00000062380 Description: tubulin%2C beta 3 class III [Source:MGI Symbol;Acc:MGI:107813] Location: 8:124138163-124148754 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell neuron motor neuron Other: Cytokine Signaling in Immune system Adaptive Immune System Macroautophagy
Non-integrin membrane-ECM interactions Pathway Hierarchies & Genes Syndecan interactions (6 genes) Extracellular matrix organization Non-integrin membrane-ECM interactions Syndecan interactions 6 genes	Itga2 Gene Information Basic Information Ensembl ID: ENSMUSG00000015533 Description: integrin alpha 2 [Source:MGI Symbol;Acc:MGI:96600] Location: 13:114969617-115068636 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Specialized T cell Other: Integrin cell surface interactions Non-integrin membrane-ECM interactions ECM proteoglycans Itga6 Gene Information Basic Information Ensembl ID: ENSMUSG00000027111 Description: integrin alpha 6 [Source:MGI Symbol;Acc:MGI:96605] Location: 2:71575960-71688760 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell epithelial cell progenitor cell Other: Cell surface interactions at the vascular wall Integrin cell surface interactions Laminin interactions Itgb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000025809 Description: integrin beta 1 (fibronectin receptor beta) [Source:MGI Symbol;Acc:MGI:96610] Location: 8:129412135-129459681 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell pericyte stellate cell stromal cell smooth muscle cell fibroblast muscle cell mural cell basal cell kidney cell Other: Laminin interactions Adaptive Immune System Elastic fibre formation Itgb3 Gene Information Basic Information Ensembl ID: ENSMUSG00000020689 Description: integrin beta 3 [Source:MGI Symbol;Acc:MGI:96612] Location: 11:104498826-104561302 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell stromal cell bone cell megakaryocyte Other: Elastic fibre formation Cell surface interactions at the vascular wall Integrin cell surface interactions Sdc1 Gene Information Basic Information Ensembl ID: ENSMUSG00000020592 Description: syndecan 1 [Source:MGI Symbol;Acc:MGI:1349162] Location: 12:8821323-8843715 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte stem cell epithelial cell pneumocyte Naive B cell basal cell plasma cell leukocyte T cell Specialized T cell Other: Cytokine Signaling in Immune system Metabolism of vitamins and cofactors Cell surface interactions at the vascular wall Tgfb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000002603 Description: transforming growth factor%2C beta 1 [Source:MGI Symbol;Acc:MGI:98725] Location: 7:25386427-25404502 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell hematopoietic stem cell phagocyte monocyte leukocyte megakaryocyte Other: Cell surface interactions at the vascular wall Non-integrin membrane-ECM interactions Elastic fibre formation
O2/CO2 exchange in erythrocytes Pathway Hierarchies & Genes Erythrocytes take up oxygen and release carbon dioxide (1 genes) Transport of small molecules O2/CO2 exchange in erythrocytes Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide 1 genes	Slc4a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000006574 Description: solute carrier family 4 (anion exchanger)%2C member 1 [Source:MGI Symbol;Acc:MGI:109393] Location: 11:102239650-102257029 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: erythrocyte hematopoietic progenitor cell granulocyte erythroblast Other: O2/CO2 exchange in erythrocytes SLC-mediated transmembrane transport
Paracetamol ADME Pathway Hierarchies & Genes Paracetamol ADME (1 genes) Drug ADME Paracetamol ADME 1 genes	Cndp2 Gene Information Basic Information Ensembl ID: ENSMUSG00000024644 Description: CNDP dipeptidase 2 [Source:MGI Symbol;Acc:MGI:1913304] Location: 18:84685590-84703827 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell phagocyte antigen presenting cell monocyte macrophage Other: Biological oxidations Paracetamol ADME
Peptide hormone metabolism Pathway Hierarchies & Genes Metabolism of Angiotensinogen to Angiotensins (1 genes) Metabolism of proteins Peptide hormone metabolism Metabolism of Angiotensinogen to Angiotensins 1 genes	Ace2 Gene Information Basic Information Ensembl ID: ENSMUSG00000015405 Description: angiotensin converting enzyme 2 [Source:MGI Symbol;Acc:MGI:1917258] Location: X:162922328-162971416 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte epithelial cell Other: Peptide hormone metabolism
Peroxisomal protein import Pathway Hierarchies & Genes Peroxisomal protein import (2 genes) Protein localization Peroxisomal protein import 2 genes	Dao Gene Information Basic Information Ensembl ID: ENSMUSG00000042096 Description: D-amino acid oxidase [Source:MGI Symbol;Acc:MGI:94859] Location: 5:114141764-114163743 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Metabolism of amino acids and derivatives Peroxisomal protein import Nos2 Gene Information Basic Information Ensembl ID: ENSMUSG00000020826 Description: nitric oxide synthase 2%2C inducible [Source:MGI Symbol;Acc:MGI:97361] Location: 11:78811613-78851080 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: macrophage Other: Innate Immune System Platelet homeostasis Peroxisomal protein import
Plasma lipoprotein assembly, remodeling, and clearance Pathway Hierarchies & Genes HDL remodeling (1 genes) Transport of small molecules Plasma lipoprotein assembly, remodeling, and clearance Plasma lipoprotein remodeling HDL remodeling 1 genes	Lipg Gene Information Basic Information Ensembl ID: ENSMUSG00000053846 Description: lipase%2C endothelial [Source:MGI Symbol;Acc:MGI:1341803] Location: 18:75072393-75094334 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte Other: Plasma lipoprotein assembly, remodeling, and clearance
Platelet Adhesion to exposed collagen Pathway Hierarchies & Genes Platelet Adhesion to exposed collagen (1 genes) Hemostasis Platelet Adhesion to exposed collagen 1 genes	Vwf Gene Information Basic Information Ensembl ID: ENSMUSG00000001930 Description: Von Willebrand factor [Source:MGI Symbol;Acc:MGI:98941] Location: 6:125523737-125663642 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell endocardial cell endodermal cell hematopoietic stem cell Other: Formation of Fibrin Clot (Clotting Cascade) Integrin cell surface interactions Integrin signaling
Platelet activation, signaling and aggregation Pathway Hierarchies & Genes Platelet Aggregation (Plug Formation) (9 genes) Hemostasis Platelet activation, signaling and aggregation Response to elevated platelet cytosolic Ca2+ Platelet degranulation 7 genes GP1b-IX-V activation signalling 1 genes Platelet Aggregation (Plug Formation) 1 genes Arachidonate production from DAG (1 genes) Hemostasis Platelet activation, signaling and aggregation Effects of PIP2 hydrolysis Arachidonate production from DAG 1 genes	Cd36 Gene Information Basic Information Ensembl ID: ENSMUSG00000002944 Description: CD36 molecule [Source:MGI Symbol;Acc:MGI:107899] Location: 5:17986688-18093799 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: macrophage Other: Adaptive Immune System Integration of energy metabolism Innate Immune System F13a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000039109 Description: coagulation factor XIII%2C A1 subunit [Source:MGI Symbol;Acc:MGI:1921395] Location: 13:37051152-37234220 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: hematopoietic stem cell phagocyte monocyte erythroid lineage cell T cell macrophage Other: Formation of Fibrin Clot (Clotting Cascade) Platelet activation, signaling and aggregation Hrg Gene Information Basic Information Ensembl ID: ENSMUSG00000022877 Description: histidine-rich glycoprotein [Source:MGI Symbol;Acc:MGI:2146636] Location: 16:22769822-22780406 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Dissolution of Fibrin Clot Platelet activation, signaling and aggregation Itgb3 Gene Information Basic Information Ensembl ID: ENSMUSG00000020689 Description: integrin beta 3 [Source:MGI Symbol;Acc:MGI:96612] Location: 11:104498826-104561302 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell stromal cell bone cell megakaryocyte Other: Elastic fibre formation Cell surface interactions at the vascular wall Integrin cell surface interactions Mgll Gene Information Basic Information Ensembl ID: ENSMUSG00000033174 Description: monoglyceride lipase [Source:MGI Symbol;Acc:MGI:1346042] Location: 6:88701394-88805342 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell pancreatic cell smooth muscle cell astrocyte Other: Signaling by GPCR Metabolism of lipids Platelet activation, signaling and aggregation Mmrn1 Gene Information Basic Information Ensembl ID: ENSMUSG00000054641 Description: multimerin 1 [Source:MGI Symbol;Acc:MGI:1918195] Location: 6:60901960-60966362 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Post-translational protein modification Platelet activation, signaling and aggregation Pecam1 Gene Information Basic Information Ensembl ID: ENSMUSG00000020717 Description: platelet/endothelial cell adhesion molecule 1 [Source:MGI Symbol;Acc:MGI:97537] Location: 11:106545043-106641454 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell epithelial cell Other: Innate Immune System Cell surface interactions at the vascular wall Integrin cell surface interactions Scg3 Gene Information Basic Information Ensembl ID: ENSMUSG00000032181 Description: secretogranin III [Source:MGI Symbol;Acc:MGI:103032] Location: 9:75550471-75591338 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endocrine cell astrocyte enteroendocrine cell photoreceptor cell Other: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein modification Platelet activation, signaling and aggregation Tgfb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000002603 Description: transforming growth factor%2C beta 1 [Source:MGI Symbol;Acc:MGI:98725] Location: 7:25386427-25404502 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell hematopoietic stem cell phagocyte monocyte leukocyte megakaryocyte Other: Cell surface interactions at the vascular wall Non-integrin membrane-ECM interactions Elastic fibre formation Vwf Gene Information Basic Information Ensembl ID: ENSMUSG00000001930 Description: Von Willebrand factor [Source:MGI Symbol;Acc:MGI:98941] Location: 6:125523737-125663642 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell endocardial cell endodermal cell hematopoietic stem cell Other: Formation of Fibrin Clot (Clotting Cascade) Integrin cell surface interactions Integrin signaling
Platelet homeostasis Pathway Hierarchies & Genes Nitric oxide stimulates guanylate cyclase (1 genes) Hemostasis Platelet homeostasis Nitric oxide stimulates guanylate cyclase 1 genes Platelet sensitization by LDL (1 genes) Hemostasis Platelet homeostasis Platelet sensitization by LDL 1 genes	Nos2 Gene Information Basic Information Ensembl ID: ENSMUSG00000020826 Description: nitric oxide synthase 2%2C inducible [Source:MGI Symbol;Acc:MGI:97361] Location: 11:78811613-78851080 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: macrophage Other: Innate Immune System Platelet homeostasis Peroxisomal protein import Pecam1 Gene Information Basic Information Ensembl ID: ENSMUSG00000020717 Description: platelet/endothelial cell adhesion molecule 1 [Source:MGI Symbol;Acc:MGI:97537] Location: 11:106545043-106641454 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell epithelial cell Other: Innate Immune System Cell surface interactions at the vascular wall Integrin cell surface interactions
Post-translational protein modification Pathway Hierarchies & Genes N-Glycan antennae elongation (1 genes) Metabolism of proteins Post-translational protein modification Asparagine N-linked glycosylation Transport to the Golgi and subsequent modification N-glycan antennae elongation in the medial/trans-Golgi N-Glycan antennae elongation 1 genes Carboxyterminal post-translational modifications of tubulin (2 genes) Metabolism of proteins Post-translational protein modification Asparagine N-linked glycosylation Transport to the Golgi and subsequent modification 1 genes Carboxyterminal post-translational modifications of tubulin 1 genes SUMOylation of chromatin organization proteins (1 genes) Metabolism of proteins Post-translational protein modification SUMOylation SUMO E3 ligases SUMOylate target proteins SUMOylation of chromatin organization proteins 1 genes Termination of O-glycan biosynthesis (1 genes) Metabolism of proteins Post-translational protein modification O-linked glycosylation O-linked glycosylation of mucins Termination of O-glycan biosynthesis 1 genes Ub-specific processing proteases (2 genes) Metabolism of proteins Post-translational protein modification Deubiquitination Ub-specific processing proteases 2 genes Asparagine N-linked glycosylation (1 genes) Metabolism of proteins Post-translational protein modification Asparagine N-linked glycosylation 1 genes Neddylation (1 genes) Metabolism of proteins Post-translational protein modification Neddylation 1 genes O-linked glycosylation (1 genes) Metabolism of proteins Post-translational protein modification O-linked glycosylation 1 genes Post-translational modification: synthesis of GPI-anchored proteins (3 genes) Metabolism of proteins Post-translational protein modification Post-translational modification: synthesis of GPI-anchored proteins 3 genes Post-translational protein phosphorylation (8 genes) Metabolism of proteins Post-translational protein modification Post-translational protein phosphorylation 8 genes Proteasome assembly (1 genes) Metabolism of proteins Post-translational protein modification Proteasome assembly 1 genes RAB geranylgeranylation (1 genes) Metabolism of proteins Post-translational protein modification RAB geranylgeranylation 1 genes	Areg Gene Information Basic Information Ensembl ID: ENSMUSG00000029378 Description: amphiregulin [Source:MGI Symbol;Acc:MGI:88068] Location: 5:91287458-91296291 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell innate lymphoid cell Other: Post-translational protein modification Membrane Trafficking MAPK family signaling cascades Asb9 Gene Information Basic Information Ensembl ID: ENSMUSG00000031384 Description: ankyrin repeat and SOCS box-containing 9 [Source:MGI Symbol;Acc:MGI:1916549] Location: X:163289323-163322748 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Adaptive Immune System Post-translational protein modification B4galnt2 Gene Information Basic Information Ensembl ID: ENSMUSG00000013418 Description: beta-1%2C4-N-acetyl-galactosaminyl transferase 2 [Source:MGI Symbol;Acc:MGI:1342058] Location: 11:95756769-95805717 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Post-translational protein modification Metabolism of carbohydrates and carbohydrate derivatives Bst1 Gene Information Basic Information Ensembl ID: ENSMUSG00000029082 Description: bone marrow stromal cell antigen 1 [Source:MGI Symbol;Acc:MGI:105370] Location: 5:43976227-44001328 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell macrophage Other: Innate Immune System Metabolism of vitamins and cofactors Post-translational protein modification Chgb Gene Information Basic Information Ensembl ID: ENSMUSG00000027350 Description: chromogranin B [Source:MGI Symbol;Acc:MGI:88395] Location: 2:132623198-132636999 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endocrine cell retina cell excitatory neuron enteroendocrine cell Other: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein modification Cp Gene Information Basic Information Ensembl ID: ENSMUSG00000003617 Description: ceruloplasmin [Source:MGI Symbol;Acc:MGI:88476] Location: 3:20011218-20063309 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell fibroblast stellate cell pericyte stem cell stromal cell basal cell glial cell epithelial cell Other: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) SLC-mediated transmembrane transport Post-translational protein modification Gata3 Gene Information Basic Information Ensembl ID: ENSMUSG00000015619 Description: GATA binding protein 3 [Source:MGI Symbol;Acc:MGI:95663] Location: 2:9861889-9894845 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Regulatory T cell epithelial cell stem cell CD4+ T cell innate lymphoid cell developing T cell mesangial cell Other: Post-translational protein modification RNA Polymerase II Transcription Signaling by Nuclear Receptors Gp2 Gene Information Basic Information Ensembl ID: ENSMUSG00000030954 Description: glycoprotein 2 zymogen granule membrane [Source:MGI Symbol;Acc:MGI:1914383] Location: 7:119041760-119058508 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell pancreatic cell Other: Post-translational protein modification Hrc Gene Information Basic Information Ensembl ID: ENSMUSG00000038239 Description: histidine rich calcium binding protein [Source:MGI Symbol;Acc:MGI:96226] Location: 7:44984714-44988398 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: skeletal muscle cell Other: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein modification Il6 Gene Information Basic Information Ensembl ID: ENSMUSG00000025746 Description: interleukin 6 [Source:MGI Symbol;Acc:MGI:96559] Location: 5:30218112-30224979 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stem cell endothelial cell basophil eosinophil mural cell Other: Cytokine Signaling in Immune system Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MAPK family signaling cascades Ly6h Gene Information Basic Information Ensembl ID: ENSMUSG00000022577 Description: lymphocyte antigen 6 family member H [Source:MGI Symbol;Acc:MGI:1346030] Location: 15:75424894-75439104 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: enteroendocrine cell cajal-retzius cell Other: Post-translational protein modification Mgat4c Gene Information Basic Information Ensembl ID: ENSMUSG00000019888 Description: MGAT4 family%2C member C [Source:MGI Symbol;Acc:MGI:1914819] Location: 10:101517348-102227330 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell neuron excitatory neuron principal cell inhibitory neuron Other: Post-translational protein modification Mmrn1 Gene Information Basic Information Ensembl ID: ENSMUSG00000054641 Description: multimerin 1 [Source:MGI Symbol;Acc:MGI:1918195] Location: 6:60901960-60966362 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Other: Post-translational protein modification Platelet activation, signaling and aggregation Muc1 Gene Information Basic Information Ensembl ID: ENSMUSG00000042784 Description: mucin 1%2C transmembrane [Source:MGI Symbol;Acc:MGI:97231] Location: 3:89136364-89140688 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pneumocyte epithelial cell Other: Post-translational protein modification Myc Gene Information Basic Information Ensembl ID: ENSMUSG00000022346 Description: myelocytomatosis oncogene [Source:MGI Symbol;Acc:MGI:97250] Location: 15:61857240-61862223 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Post-translational protein modification RNA Polymerase II Transcription Prss23 Gene Information Basic Information Ensembl ID: ENSMUSG00000039405 Description: serine protease 23 [Source:MGI Symbol;Acc:MGI:1923703] Location: 7:89156991-89176395 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell neuron stem cell fibroblast smooth muscle cell muscle cell Other: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein modification Psmb8 Gene Information Basic Information Ensembl ID: ENSMUSG00000024338 Description: proteasome (prosome%2C macropain) subunit%2C beta type 8 (large multifunctional peptidase 7) [Source:MGI Symbol;Acc:MGI:1346527] Location: 17:34416695-34420428 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell dendritic cell developing T cell Regulatory T cell Naive B cell monocyte endothelial cell CD8+ T cell macrophage lymphocyte T cell Other: Adaptive Immune System Post-translational protein modification Rab3b Gene Information Basic Information Ensembl ID: ENSMUSG00000003411 Description: RAB3B%2C member RAS oncogene family [Source:MGI Symbol;Acc:MGI:1917158] Location: 4:108736260-108800521 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: interneuron epithelial cell Other: Post-translational protein modification Satb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000023927 Description: special AT-rich sequence binding protein 1 [Source:MGI Symbol;Acc:MGI:105084] Location: 17:52043215-52140318 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell developing T cell excitatory neuron Specialized T cell innate lymphoid cell lymphocyte Other: Apoptosis Post-translational protein modification Scg2 Gene Information Basic Information Ensembl ID: ENSMUSG00000050711 Description: secretogranin II [Source:MGI Symbol;Acc:MGI:103033] Location: 1:79412386-79417837 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron endocrine cell enteroendocrine cell Other: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein modification Scg3 Gene Information Basic Information Ensembl ID: ENSMUSG00000032181 Description: secretogranin III [Source:MGI Symbol;Acc:MGI:103032] Location: 9:75550471-75591338 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endocrine cell astrocyte enteroendocrine cell photoreceptor cell Other: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein modification Platelet activation, signaling and aggregation Serpina10 Gene Information Basic Information Ensembl ID: ENSMUSG00000061947 Description: serine (or cysteine) peptidase inhibitor%2C clade A (alpha-1 antiproteinase%2C antitrypsin)%2C member 10 [Source:MGI Symbol;Acc:MGI:2667725] Location: 12:103581045-103597703 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein modification Tubb3 Gene Information Basic Information Ensembl ID: ENSMUSG00000062380 Description: tubulin%2C beta 3 class III [Source:MGI Symbol;Acc:MGI:107813] Location: 8:124138163-124148754 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell neuron motor neuron Other: Cytokine Signaling in Immune system Adaptive Immune System Macroautophagy
Potassium Channels Pathway Hierarchies & Genes Activation of G protein gated Potassium channels (1 genes) Neuronal System Potassium Channels Inwardly rectifying K+ channels G protein gated Potassium channels Activation of G protein gated Potassium channels 1 genes Potassium transport channels (1 genes) Neuronal System Potassium Channels Inwardly rectifying K+ channels Potassium transport channels 1 genes Voltage gated Potassium channels (1 genes) Neuronal System Potassium Channels Voltage gated Potassium channels 1 genes	Kcna1 Gene Information Basic Information Ensembl ID: ENSMUSG00000047976 Description: potassium voltage-gated channel%2C shaker-related subfamily%2C member 1 [Source:MGI Symbol;Acc:MGI:96654] Location: 6:126617360-126623347 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron glial cell oligodendrocyte Other: Potassium Channels Kcnj1 Gene Information Basic Information Ensembl ID: ENSMUSG00000041248 Description: potassium inwardly-rectifying channel%2C subfamily J%2C member 1 [Source:MGI Symbol;Acc:MGI:1927248] Location: 9:32283789-32310493 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Potassium Channels Kcnj16 Gene Information Basic Information Ensembl ID: ENSMUSG00000051497 Description: potassium inwardly-rectifying channel%2C subfamily J%2C member 16 [Source:MGI Symbol;Acc:MGI:1314842] Location: 11:110858859-110918794 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Transmission across Chemical Synapses Potassium Channels
RNA Polymerase II Transcription Pathway Hierarchies & Genes RUNX2 regulates osteoblast differentiation (1 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional regulation by RUNX2 RUNX2 regulates bone development RUNX2 regulates osteoblast differentiation 1 genes RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) (1 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional regulation by RUNX1 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 1 genes RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (1 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional regulation by RUNX1 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 1 genes RUNX1 regulates transcription of genes involved in BCR signaling (1 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional regulation by RUNX1 RUNX1 regulates transcription of genes involved in BCR signaling 1 genes RUNX1 regulates transcription of genes involved in differentiation of HSCs (1 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional regulation by RUNX1 RUNX1 regulates transcription of genes involved in differentiation of HSCs 1 genes RUNX3 regulates CDKN1A transcription (1 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional regulation by RUNX3 RUNX3 regulates CDKN1A transcription 1 genes TFAP2 (AP-2) family regulates transcription of cell cycle factors (1 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors TFAP2 (AP-2) family regulates transcription of cell cycle factors 1 genes Nuclear Receptor transcription pathway (1 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Nuclear Receptor transcription pathway 1 genes Transcriptional regulation by RUNX2 (1 genes) Gene expression (Transcription) RNA Polymerase II Transcription Generic Transcription Pathway Transcriptional regulation by RUNX2 1 genes	Actl6b Gene Information Basic Information Ensembl ID: ENSMUSG00000029712 Description: actin-like 6B [Source:MGI Symbol;Acc:MGI:1933548] Location: 5:137551779-137567844 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Chromatin modifying enzymes RNA Polymerase II Transcription Foxp3 Gene Information Basic Information Ensembl ID: ENSMUSG00000039521 Description: forkhead box P3 [Source:MGI Symbol;Acc:MGI:1891436] Location: X:7439883-7461484 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Regulatory T cell CD4+ T cell developing T cell Other: RNA Polymerase II Transcription Gata3 Gene Information Basic Information Ensembl ID: ENSMUSG00000015619 Description: GATA binding protein 3 [Source:MGI Symbol;Acc:MGI:95663] Location: 2:9861889-9894845 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Regulatory T cell epithelial cell stem cell CD4+ T cell innate lymphoid cell developing T cell mesangial cell Other: Post-translational protein modification RNA Polymerase II Transcription Signaling by Nuclear Receptors Myc Gene Information Basic Information Ensembl ID: ENSMUSG00000022346 Description: myelocytomatosis oncogene [Source:MGI Symbol;Acc:MGI:97250] Location: 15:61857240-61862223 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Post-translational protein modification RNA Polymerase II Transcription Pax5 Gene Information Basic Information Ensembl ID: ENSMUSG00000014030 Description: paired box 5 [Source:MGI Symbol;Acc:MGI:97489] Location: 4:44524757-44710487 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Naive B cell Other: RNA Polymerase II Transcription Rorc Gene Information Basic Information Ensembl ID: ENSMUSG00000028150 Description: RAR-related orphan receptor gamma [Source:MGI Symbol;Acc:MGI:104856] Location: 3:94280101-94305583 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: innate lymphoid cell Other: RNA Polymerase II Transcription Runx2 Gene Information Basic Information Ensembl ID: ENSMUSG00000039153 Description: runt related transcription factor 2 [Source:MGI Symbol;Acc:MGI:99829] Location: 17:44806874-45125684 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: hematopoietic stem cell osteoblast dendritic cell myeloid progenitor cell bone cell epithelial cell Other: RNA Polymerase II Transcription Sox9 Gene Information Basic Information Ensembl ID: ENSMUSG00000000567 Description: SRY (sex determining region Y)-box 9 [Source:MGI Symbol;Acc:MGI:98371] Location: 11:112673050-112678586 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell stromal cell tuft cell muscle cell chondrocyte bone cell progenitor cell hepatocyte natural killer cell stem cell Other: Signaling by WNT RNA Polymerase II Transcription Tgfb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000002603 Description: transforming growth factor%2C beta 1 [Source:MGI Symbol;Acc:MGI:98725] Location: 7:25386427-25404502 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell hematopoietic stem cell phagocyte monocyte leukocyte megakaryocyte Other: Cell surface interactions at the vascular wall Non-integrin membrane-ECM interactions Elastic fibre formation
Regulated Necrosis Pathway Hierarchies & Genes CASP8 activity is inhibited (2 genes) Programmed Cell Death Regulated Necrosis RIPK1-mediated regulated necrosis Regulation of necroptotic cell death CASP8 activity is inhibited 2 genes	Fas Gene Information Basic Information Ensembl ID: ENSMUSG00000024778 Description: Fas cell surface death receptor [Source:MGI Symbol;Acc:MGI:95484] Location: 19:34268066-34305172 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell smooth muscle cell Other: Apoptosis Regulated Necrosis Death Receptor Signaling Fasl Gene Information Basic Information Ensembl ID: ENSMUSG00000000817 Description: Fas ligand [Source:MGI Symbol;Acc:MGI:99255] Location: 1:161608258-161616064 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell CD8+ T cell T cell Other: Apoptosis Regulated Necrosis Death Receptor Signaling
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway Hierarchies & Genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (9 genes) Metabolism of proteins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 9 genes	Chgb Gene Information Basic Information Ensembl ID: ENSMUSG00000027350 Description: chromogranin B [Source:MGI Symbol;Acc:MGI:88395] Location: 2:132623198-132636999 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endocrine cell retina cell excitatory neuron enteroendocrine cell Other: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein modification Cp Gene Information Basic Information Ensembl ID: ENSMUSG00000003617 Description: ceruloplasmin [Source:MGI Symbol;Acc:MGI:88476] Location: 3:20011218-20063309 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell fibroblast stellate cell pericyte stem cell stromal cell basal cell glial cell epithelial cell Other: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) SLC-mediated transmembrane transport Post-translational protein modification Hrc Gene Information Basic Information Ensembl ID: ENSMUSG00000038239 Description: histidine rich calcium binding protein [Source:MGI Symbol;Acc:MGI:96226] Location: 7:44984714-44988398 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: skeletal muscle cell Other: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein modification Igfbp6 Gene Information Basic Information Ensembl ID: ENSMUSG00000023046 Description: insulin-like growth factor binding protein 6 [Source:MGI Symbol;Acc:MGI:96441] Location: 15:102052797-102057946 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stellate cell stem cell stromal cell epithelial cell Other: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Il6 Gene Information Basic Information Ensembl ID: ENSMUSG00000025746 Description: interleukin 6 [Source:MGI Symbol;Acc:MGI:96559] Location: 5:30218112-30224979 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stem cell endothelial cell basophil eosinophil mural cell Other: Cytokine Signaling in Immune system Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MAPK family signaling cascades Prss23 Gene Information Basic Information Ensembl ID: ENSMUSG00000039405 Description: serine protease 23 [Source:MGI Symbol;Acc:MGI:1923703] Location: 7:89156991-89176395 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell neuron stem cell fibroblast smooth muscle cell muscle cell Other: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein modification Scg2 Gene Information Basic Information Ensembl ID: ENSMUSG00000050711 Description: secretogranin II [Source:MGI Symbol;Acc:MGI:103033] Location: 1:79412386-79417837 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron endocrine cell enteroendocrine cell Other: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein modification Scg3 Gene Information Basic Information Ensembl ID: ENSMUSG00000032181 Description: secretogranin III [Source:MGI Symbol;Acc:MGI:103032] Location: 9:75550471-75591338 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endocrine cell astrocyte enteroendocrine cell photoreceptor cell Other: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein modification Platelet activation, signaling and aggregation Serpina10 Gene Information Basic Information Ensembl ID: ENSMUSG00000061947 Description: serine (or cysteine) peptidase inhibitor%2C clade A (alpha-1 antiproteinase%2C antitrypsin)%2C member 10 [Source:MGI Symbol;Acc:MGI:2667725] Location: 12:103581045-103597703 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein modification
Reversible hydration of carbon dioxide Pathway Hierarchies & Genes Reversible hydration of carbon dioxide (1 genes) Metabolism Reversible hydration of carbon dioxide 1 genes	Car3 Gene Information Basic Information Ensembl ID: ENSMUSG00000027559 Description: carbonic anhydrase 3 [Source:MGI Symbol;Acc:MGI:88270] Location: 3:14928572-14937583 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: preadipocyte epithelial cell skeletal muscle cell adipocyte Other: Reversible hydration of carbon dioxide
SLC-mediated transmembrane transport Pathway Hierarchies & Genes Organic anion transport (2 genes) Transport of small molecules SLC-mediated transmembrane transport Transport of bile salts and organic acids, metal ions and amine compounds Organic cation/anion/zwitterion transport Organic anion transport 2 genes Bicarbonate transporters (2 genes) Transport of small molecules SLC-mediated transmembrane transport Transport of inorganic cations/anions and amino acids/oligopeptides Bicarbonate transporters 2 genes Metal ion SLC transporters (1 genes) Transport of small molecules SLC-mediated transmembrane transport Transport of bile salts and organic acids, metal ions and amine compounds Metal ion SLC transporters 1 genes Organic anion transporters (1 genes) Transport of small molecules SLC-mediated transmembrane transport Transport of inorganic cations/anions and amino acids/oligopeptides Organic anion transporters 1 genes Proton-coupled monocarboxylate transport (1 genes) Transport of small molecules SLC-mediated transmembrane transport Transport of bile salts and organic acids, metal ions and amine compounds Proton-coupled monocarboxylate transport 1 genes Rhesus glycoproteins mediate ammonium transport (1 genes) Transport of small molecules SLC-mediated transmembrane transport Transport of bile salts and organic acids, metal ions and amine compounds Rhesus glycoproteins mediate ammonium transport 1 genes Cellular hexose transport (1 genes) Transport of small molecules SLC-mediated transmembrane transport Cellular hexose transport 1 genes Transport of bile salts and organic acids, metal ions and amine compounds (2 genes) Transport of small molecules SLC-mediated transmembrane transport Transport of bile salts and organic acids, metal ions and amine compounds 2 genes	Cp Gene Information Basic Information Ensembl ID: ENSMUSG00000003617 Description: ceruloplasmin [Source:MGI Symbol;Acc:MGI:88476] Location: 3:20011218-20063309 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell fibroblast stellate cell pericyte stem cell stromal cell basal cell glial cell epithelial cell Other: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) SLC-mediated transmembrane transport Post-translational protein modification Emb Gene Information Basic Information Ensembl ID: ENSMUSG00000021728 Description: embigin [Source:MGI Symbol;Acc:MGI:95321] Location: 13:117345072-117410951 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell developing T cell hematopoietic stem cell stem cell dendritic cell leukocyte granulocyte monocyte Other: SLC-mediated transmembrane transport Rhcg Gene Information Basic Information Ensembl ID: ENSMUSG00000030549 Description: Rhesus blood group-associated C glycoprotein [Source:MGI Symbol;Acc:MGI:1888517] Location: 7:79243111-79267405 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: kidney cell epithelial cell Other: SLC-mediated transmembrane transport Slc14a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000059336 Description: solute carrier family 14 (urea transporter)%2C member 1 [Source:MGI Symbol;Acc:MGI:1351654] Location: 18:78143306-78185334 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell endothelial cell megakaryocyte Other: SLC-mediated transmembrane transport Slc14a2 Gene Information Basic Information Ensembl ID: ENSMUSG00000024552 Description: solute carrier family 14 (urea transporter)%2C member 2 [Source:MGI Symbol;Acc:MGI:1351653] Location: 18:78189363-78640157 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: principal cell loop of henle cell Other: SLC-mediated transmembrane transport Slc17a7 Gene Information Basic Information Ensembl ID: ENSMUSG00000070570 Description: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter)%2C member 7 [Source:MGI Symbol;Acc:MGI:1920211] Location: 7:44813373-44825566 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron excitatory neuron Other: Transmission across Chemical Synapses SLC-mediated transmembrane transport Slc22a6 Gene Information Basic Information Ensembl ID: ENSMUSG00000024650 Description: solute carrier family 22 (organic anion transporter)%2C member 6 [Source:MGI Symbol;Acc:MGI:892001] Location: 19:8595403-8605663 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast epithelial cell proximal tubule cell Other: SLC-mediated transmembrane transport Slc22a8 Gene Information Basic Information Ensembl ID: ENSMUSG00000063796 Description: solute carrier family 22 (organic anion transporter)%2C member 8 [Source:MGI Symbol;Acc:MGI:1336187] Location: 19:8568618-8589199 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell epithelial cell Other: SLC-mediated transmembrane transport Slc4a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000006574 Description: solute carrier family 4 (anion exchanger)%2C member 1 [Source:MGI Symbol;Acc:MGI:109393] Location: 11:102239650-102257029 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: erythrocyte hematopoietic progenitor cell granulocyte erythroblast Other: O2/CO2 exchange in erythrocytes SLC-mediated transmembrane transport Slc4a4 Gene Information Basic Information Ensembl ID: ENSMUSG00000060961 Description: solute carrier family 4 (anion exchanger)%2C member 4 [Source:MGI Symbol;Acc:MGI:1927555] Location: 5:89034345-89387512 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: bergmann glial cell adipocyte epithelial cell fibroblast glial cell astrocyte Other: SLC-mediated transmembrane transport Slc5a1 Gene Information Basic Information Ensembl ID: ENSMUSG00000011034 Description: solute carrier family 5 (sodium/glucose cotransporter)%2C member 1 [Source:MGI Symbol;Acc:MGI:107678] Location: 5:33261563-33320214 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: SLC-mediated transmembrane transport Intestinal absorption
Signaling by GPCR Pathway Hierarchies & Genes G alpha (i) signalling events (17 genes) Signal Transduction Signaling by GPCR GPCR ligand binding Class A/1 (Rhodopsin-like receptors) Peptide ligand-binding receptors Chemokine receptors bind chemokines 1 genes GPCR downstream signalling G alpha (i) signalling events 16 genes G alpha (q) signalling events (1 genes) Signal Transduction Signaling by GPCR GPCR ligand binding Class A/1 (Rhodopsin-like receptors) Peptide ligand-binding receptors Formyl peptide receptors bind formyl peptides and many other ligands GPCR downstream signalling G alpha (q) signalling events 1 genes G alpha (i) signalling events (1 genes) Signal Transduction Signaling by GPCR GPCR ligand binding Class A/1 (Rhodopsin-like receptors) Opsins GPCR downstream signalling G alpha (i) signalling events 1 genes G alpha (q) signalling events (3 genes) Signal Transduction Signaling by GPCR GPCR ligand binding Class A/1 (Rhodopsin-like receptors) Peptide ligand-binding receptors GPCR downstream signalling G alpha (q) signalling events 3 genes G alpha (s) signalling events (1 genes) Signal Transduction Signaling by GPCR GPCR ligand binding Class B/2 (Secretin family receptors) Calcitonin-like ligand receptors GPCR downstream signalling G alpha (s) signalling events 1 genes EGFR Transactivation by Gastrin (1 genes) Signal Transduction Signaling by GPCR GPCR downstream signalling G alpha (q) signalling events Gastrin-CREB signalling pathway via PKC and MAPK EGFR Transactivation by Gastrin 1 genes GPER1 signaling (1 genes) Signal Transduction Signaling by GPCR GPCR downstream signalling G alpha (s) signalling events GPER1 signaling 1 genes Class B/2 (Secretin family receptors) (1 genes) Signal Transduction Signaling by GPCR GPCR ligand binding Class B/2 (Secretin family receptors) 1 genes G alpha (i) signalling events (1 genes) Signal Transduction Signaling by GPCR GPCR downstream signalling G alpha (i) signalling events 1 genes G alpha (q) signalling events (1 genes) Signal Transduction Signaling by GPCR GPCR downstream signalling G alpha (q) signalling events 1 genes	Ackr3 Gene Information Basic Information Ensembl ID: ENSMUSG00000044337 Description: atypical chemokine receptor 3 [Source:MGI Symbol;Acc:MGI:109562] Location: 1:90131702-90144473 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell endothelial cell Other: Signaling by GPCR Adgre1 Gene Information Basic Information Ensembl ID: ENSMUSG00000004730 Description: adhesion G protein-coupled receptor E1 [Source:MGI Symbol;Acc:MGI:106912] Location: 17:57665691-57790527 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte microglia antigen presenting cell T cell macrophage monocyte lymphocyte eosinophil myeloid cell Naive B cell kupffer cell Other: Signaling by GPCR C5ar1 Gene Information Basic Information Ensembl ID: ENSMUSG00000049130 Description: complement component 5a receptor 1 [Source:MGI Symbol;Acc:MGI:88232] Location: 7:15980668-15993465 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell phagocyte granulocyte myeloid cell T cell monocyte macrophage leukocyte Other: Innate Immune System Signaling by GPCR Calcrl Gene Information Basic Information Ensembl ID: ENSMUSG00000059588 Description: calcitonin receptor-like [Source:MGI Symbol;Acc:MGI:1926944] Location: 2:84160970-84255755 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell endocardial cell Other: Signaling by GPCR Cellular responses to mechanical stimuli Ccl22 Gene Information Basic Information Ensembl ID: ENSMUSG00000031779 Description: C-C motif chemokine ligand 22 [Source:MGI Symbol;Acc:MGI:1306779] Location: 8:95472218-95478327 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell Other: Signaling by GPCR Ccl9 Gene Information Basic Information Ensembl ID: ENSMUSG00000019122 Description: C-C motif chemokine ligand 9 [Source:MGI Symbol;Acc:MGI:104533] Location: 11:83463745-83469462 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell phagocyte monocyte dendritic cell myeloid cell erythroid lineage cell T cell leukocyte Other: Signaling by GPCR Ccr1 Gene Information Basic Information Ensembl ID: ENSMUSG00000025804 Description: C-C motif chemokine receptor 1 [Source:MGI Symbol;Acc:MGI:104618] Location: 9:123762161-123768729 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell dendritic cell phagocyte granulocyte eosinophil leukocyte Other: Signaling by GPCR Ccr10 Gene Information Basic Information Ensembl ID: ENSMUSG00000044052 Description: C-C motif chemokine receptor 10 [Source:MGI Symbol;Acc:MGI:1096320] Location: 11:101063823-101066269 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by GPCR Ccr3 Gene Information Basic Information Ensembl ID: ENSMUSG00000035448 Description: C-C motif chemokine receptor 3 [Source:MGI Symbol;Acc:MGI:104616] Location: 9:123822009-123831726 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by GPCR Ccr4 Gene Information Basic Information Ensembl ID: ENSMUSG00000047898 Description: C-C motif chemokine receptor 4 [Source:MGI Symbol;Acc:MGI:107824] Location: 9:114319384-114333984 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by GPCR Ccr5 Gene Information Basic Information Ensembl ID: ENSMUSG00000079227 Description: C-C motif chemokine receptor 5 [Source:MGI Symbol;Acc:MGI:107182] Location: 9:123921580-123947736 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell phagocyte CD8+ T cell Other: Signaling by GPCR Ccr6 Gene Information Basic Information Ensembl ID: ENSMUSG00000040899 Description: C-C motif chemokine receptor 6 [Source:MGI Symbol;Acc:MGI:1333797] Location: 17:8454875-8475973 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: memory B cell innate lymphoid cell Other: Innate Immune System Signaling by GPCR Ccr7 Gene Information Basic Information Ensembl ID: ENSMUSG00000037944 Description: C-C motif chemokine receptor 7 [Source:MGI Symbol;Acc:MGI:103011] Location: 11:99035022-99045903 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell Naive B cell developing T cell Other: Signaling by GPCR Ccr8 Gene Information Basic Information Ensembl ID: ENSMUSG00000042262 Description: C-C motif chemokine receptor 8 [Source:MGI Symbol;Acc:MGI:1201402] Location: 9:119921180-119923972 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by GPCR Cx3cr1 Gene Information Basic Information Ensembl ID: ENSMUSG00000052336 Description: C-X3-C motif chemokine receptor 1 [Source:MGI Symbol;Acc:MGI:1333815] Location: 9:119877749-119898945 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: phagocyte dendritic cell monocyte antigen presenting cell macrophage erythroblast microglia myeloid cell Other: Signaling by GPCR Cxcr1 Gene Information Basic Information Ensembl ID: ENSMUSG00000048480 Description: C-X-C motif chemokine receptor 1 [Source:MGI Symbol;Acc:MGI:2448715] Location: 1:74230944-74233790 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Signaling by GPCR Cxcr2 Gene Information Basic Information Ensembl ID: ENSMUSG00000026180 Description: C-X-C motif chemokine receptor 2 [Source:MGI Symbol;Acc:MGI:105303] Location: 1:74193150-74200405 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell granulocyte Other: Innate Immune System Signaling by GPCR Cxcr3 Gene Information Basic Information Ensembl ID: ENSMUSG00000050232 Description: C-X-C motif chemokine receptor 3 [Source:MGI Symbol;Acc:MGI:1277207] Location: X:100775141-100777875 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell developing T cell Regulatory T cell CD4+ T cell Other: Signaling by GPCR Cxcr4 Gene Information Basic Information Ensembl ID: ENSMUSG00000045382 Description: C-X-C motif chemokine receptor 4 [Source:MGI Symbol;Acc:MGI:109563] Location: 1:128515936-128520030 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell endothelial cell mast cell monocyte eosinophil progenitor cell Other: Signaling by GPCR Nervous system development Cxcr5 Gene Information Basic Information Ensembl ID: ENSMUSG00000047880 Description: C-X-C motif chemokine receptor 5 [Source:MGI Symbol;Acc:MGI:103567] Location: 9:44423084-44473174 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Naive B cell T helper cell Other: Signaling by GPCR Cxcr6 Gene Information Basic Information Ensembl ID: ENSMUSG00000048521 Description: C-X-C motif chemokine receptor 6 [Source:MGI Symbol;Acc:MGI:1934582] Location: 9:123635540-123640825 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell developing T cell CD4+ T cell Specialized T cell CD8+ T cell T cell innate lymphoid cell lymphocyte memory T cell Other: Signaling by GPCR Egfr Gene Information Basic Information Ensembl ID: ENSMUSG00000020122 Description: epidermal growth factor receptor [Source:MGI Symbol;Acc:MGI:95294] Location: 11:16702203-16868158 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stromal cell pneumocyte mesenchymal cell Other: Signaling by NOTCH Membrane Trafficking Signaling by GPCR Hc Gene Information Basic Information Ensembl ID: ENSMUSG00000026874 Description: hemolytic complement [Source:MGI Symbol;Acc:MGI:96031] Location: 2:34873343-34951450 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pneumocyte Other: Innate Immune System Signaling by GPCR Itgb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000025809 Description: integrin beta 1 (fibronectin receptor beta) [Source:MGI Symbol;Acc:MGI:96610] Location: 8:129412135-129459681 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell pericyte stellate cell stromal cell smooth muscle cell fibroblast muscle cell mural cell basal cell kidney cell Other: Laminin interactions Adaptive Immune System Elastic fibre formation Mgll Gene Information Basic Information Ensembl ID: ENSMUSG00000033174 Description: monoglyceride lipase [Source:MGI Symbol;Acc:MGI:1346042] Location: 6:88701394-88805342 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell pancreatic cell smooth muscle cell astrocyte Other: Signaling by GPCR Metabolism of lipids Platelet activation, signaling and aggregation Nts Gene Information Basic Information Ensembl ID: ENSMUSG00000019890 Description: neurotensin [Source:MGI Symbol;Acc:MGI:1328351] Location: 10:102317617-102326347 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: enteroendocrine cell endothelial cell Other: Signaling by GPCR Rho Gene Information Basic Information Ensembl ID: ENSMUSG00000030324 Description: rhodopsin [Source:MGI Symbol;Acc:MGI:97914] Location: 6:115908709-115916997 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: photoreceptor cell Other: Visual phototransduction Signaling by GPCR Cilium Assembly Xcr1 Gene Information Basic Information Ensembl ID: ENSMUSG00000060509 Description: chemokine (C motif) receptor 1 [Source:MGI Symbol;Acc:MGI:1346338] Location: 9:123681380-123691094 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell myeloid cell Other: Signaling by GPCR
Signaling by Hedgehog Pathway Hierarchies & Genes Hedgehog 'off' state (1 genes) Signal Transduction Signaling by Hedgehog Hedgehog 'off' state 1 genes	Tubb3 Gene Information Basic Information Ensembl ID: ENSMUSG00000062380 Description: tubulin%2C beta 3 class III [Source:MGI Symbol;Acc:MGI:107813] Location: 8:124138163-124148754 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell neuron motor neuron Other: Cytokine Signaling in Immune system Adaptive Immune System Macroautophagy
Signaling by NOTCH Pathway Hierarchies & Genes NOTCH3 Activation and Transmission of Signal to the Nucleus (1 genes) Signal Transduction Signaling by NOTCH Signaling by NOTCH2 NOTCH2 Activation and Transmission of Signal to the Nucleus Signaling by NOTCH3 NOTCH3 Activation and Transmission of Signal to the Nucleus 1 genes NOTCH3 Activation and Transmission of Signal to the Nucleus (1 genes) Signal Transduction Signaling by NOTCH Signaling by NOTCH3 NOTCH3 Activation and Transmission of Signal to the Nucleus 1 genes	Dll1 Gene Information Basic Information Ensembl ID: ENSMUSG00000014773 Description: delta like canonical Notch ligand 1 [Source:MGI Symbol;Acc:MGI:104659] Location: 17:15587616-15597134 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by NOTCH Egfr Gene Information Basic Information Ensembl ID: ENSMUSG00000020122 Description: epidermal growth factor receptor [Source:MGI Symbol;Acc:MGI:95294] Location: 11:16702203-16868158 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stromal cell pneumocyte mesenchymal cell Other: Signaling by NOTCH Membrane Trafficking Signaling by GPCR
Signaling by Non-Receptor Tyrosine Kinases Pathway Hierarchies & Genes PTK6 Activates STAT3 (1 genes) Signal Transduction Signaling by Non-Receptor Tyrosine Kinases Signaling by PTK6 PTK6 Activates STAT3 1 genes PTK6 promotes HIF1A stabilization (1 genes) Signal Transduction Signaling by Non-Receptor Tyrosine Kinases Signaling by PTK6 PTK6 promotes HIF1A stabilization 1 genes	Egfr Gene Information Basic Information Ensembl ID: ENSMUSG00000020122 Description: epidermal growth factor receptor [Source:MGI Symbol;Acc:MGI:95294] Location: 11:16702203-16868158 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stromal cell pneumocyte mesenchymal cell Other: Signaling by NOTCH Membrane Trafficking Signaling by GPCR Stat3 Gene Information Basic Information Ensembl ID: ENSMUSG00000004040 Description: signal transducer and activator of transcription 3 [Source:MGI Symbol;Acc:MGI:103038] Location: 11:100775924-100830366 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Signaling by Non-Receptor Tyrosine Kinases Signaling by Receptor Tyrosine Kinases
Signaling by Nuclear Receptors Pathway Hierarchies & Genes Estrogen-dependent gene expression (1 genes) Signal Transduction Signaling by Nuclear Receptors ESR-mediated signaling Estrogen-dependent gene expression 1 genes Extra-nuclear estrogen signaling (4 genes) Signal Transduction Signaling by Nuclear Receptors ESR-mediated signaling Extra-nuclear estrogen signaling 4 genes	Areg Gene Information Basic Information Ensembl ID: ENSMUSG00000029378 Description: amphiregulin [Source:MGI Symbol;Acc:MGI:88068] Location: 5:91287458-91296291 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell innate lymphoid cell Other: Post-translational protein modification Membrane Trafficking MAPK family signaling cascades Cav1 Gene Information Basic Information Ensembl ID: ENSMUSG00000007655 Description: caveolin 1%2C caveolae protein [Source:MGI Symbol;Acc:MGI:102709] Location: 6:17306334-17341451 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by WNT Metabolism of nitric oxide: NOS3 activation and regulation Cell surface interactions at the vascular wall Egfr Gene Information Basic Information Ensembl ID: ENSMUSG00000020122 Description: epidermal growth factor receptor [Source:MGI Symbol;Acc:MGI:95294] Location: 11:16702203-16868158 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stromal cell pneumocyte mesenchymal cell Other: Signaling by NOTCH Membrane Trafficking Signaling by GPCR Gata3 Gene Information Basic Information Ensembl ID: ENSMUSG00000015619 Description: GATA binding protein 3 [Source:MGI Symbol;Acc:MGI:95663] Location: 2:9861889-9894845 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Regulatory T cell epithelial cell stem cell CD4+ T cell innate lymphoid cell developing T cell mesangial cell Other: Post-translational protein modification RNA Polymerase II Transcription Signaling by Nuclear Receptors Mmp9 Gene Information Basic Information Ensembl ID: ENSMUSG00000017737 Description: matrix metallopeptidase 9 [Source:MGI Symbol;Acc:MGI:97011] Location: 2:164782700-164797770 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell bone cell granulocyte monocyte Other: Degradation of the extracellular matrix Collagen formation Innate Immune System
Signaling by Receptor Tyrosine Kinases Pathway Hierarchies & Genes IRS-related events triggered by IGF1R (2 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by Insulin receptor Insulin receptor signalling cascade IRS-mediated signalling PI3K Cascade Signaling by FGFR Signaling by FGFR1 FGFR1 ligand binding and activation 1 genes FGFR1c and Klotho ligand binding and activation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IGF1R signaling cascade IRS-related events triggered by IGF1R 1 genes MET activates STAT3 (2 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by SCF-KIT 1 genes Signaling by PDGF Downstream signal transduction Signaling by ALK STAT3 nuclear events downstream of ALK signaling Signaling by MET MET activates STAT3 1 genes GRB2 events in EGFR signaling (1 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by ERBB2 SHC1 events in ERBB2 signaling Signaling by ERBB4 Signaling by EGFR GRB2 events in EGFR signaling 1 genes MET activates PTK2 signaling (2 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by MET MET promotes cell motility MET activates PTK2 signaling 2 genes VEGF binds to VEGFR leading to receptor dimerization (1 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by VEGF VEGF ligand-receptor interactions VEGF binds to VEGFR leading to receptor dimerization 1 genes VEGFR2 mediated vascular permeability (1 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by VEGF VEGFA-VEGFR2 Pathway VEGFR2 mediated vascular permeability 1 genes GRB2 events in EGFR signaling (1 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by EGFR GRB2 events in EGFR signaling 1 genes Insulin receptor recycling (2 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by Insulin receptor Insulin receptor recycling 2 genes MDK and PTN in ALK signaling (1 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by ALK MDK and PTN in ALK signaling 1 genes Neurophilin interactions with VEGF and VEGFR (1 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by VEGF Neurophilin interactions with VEGF and VEGFR 1 genes Regulation of KIT signaling (1 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by SCF-KIT Regulation of KIT signaling 1 genes VEGFA-VEGFR2 Pathway (4 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by VEGF VEGFA-VEGFR2 Pathway 4 genes Signaling by PDGF (1 genes) Signal Transduction Signaling by Receptor Tyrosine Kinases Signaling by PDGF 1 genes	Areg Gene Information Basic Information Ensembl ID: ENSMUSG00000029378 Description: amphiregulin [Source:MGI Symbol;Acc:MGI:88068] Location: 5:91287458-91296291 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell innate lymphoid cell Other: Post-translational protein modification Membrane Trafficking MAPK family signaling cascades Atp6v0d2 Gene Information Basic Information Ensembl ID: ENSMUSG00000028238 Description: ATPase%2C H+ transporting%2C lysosomal V0 subunit D2 [Source:MGI Symbol;Acc:MGI:1924415] Location: 4:19876841-19922605 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: kidney cell phagocyte epithelial cell Other: Innate Immune System Cellular responses to stress Signaling by Receptor Tyrosine Kinases Atp6v1b1 Gene Information Basic Information Ensembl ID: ENSMUSG00000006269 Description: ATPase%2C H+ transporting%2C lysosomal V1 subunit B1 [Source:MGI Symbol;Acc:MGI:103285] Location: 6:83719972-83735837 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: kidney cell intercalated cell epithelial cell Other: Innate Immune System Cellular responses to stress Signaling by Receptor Tyrosine Kinases Axl Gene Information Basic Information Ensembl ID: ENSMUSG00000002602 Description: AXL receptor tyrosine kinase [Source:MGI Symbol;Acc:MGI:1347244] Location: 7:25456698-25488130 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast pericyte stem cell phagocyte stromal cell plasma cell kupffer cell macrophage Other: Signaling by Receptor Tyrosine Kinases Cav1 Gene Information Basic Information Ensembl ID: ENSMUSG00000007655 Description: caveolin 1%2C caveolae protein [Source:MGI Symbol;Acc:MGI:102709] Location: 6:17306334-17341451 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by WNT Metabolism of nitric oxide: NOS3 activation and regulation Cell surface interactions at the vascular wall Cybb Gene Information Basic Information Ensembl ID: ENSMUSG00000015340 Description: cytochrome b-245%2C beta polypeptide [Source:MGI Symbol;Acc:MGI:88574] Location: X:9301491-9354010 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: monocyte Other: Adaptive Immune System Innate Immune System Cellular responses to stress Egfr Gene Information Basic Information Ensembl ID: ENSMUSG00000020122 Description: epidermal growth factor receptor [Source:MGI Symbol;Acc:MGI:95294] Location: 11:16702203-16868158 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stromal cell pneumocyte mesenchymal cell Other: Signaling by NOTCH Membrane Trafficking Signaling by GPCR Itga2 Gene Information Basic Information Ensembl ID: ENSMUSG00000015533 Description: integrin alpha 2 [Source:MGI Symbol;Acc:MGI:96600] Location: 13:114969617-115068636 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell Specialized T cell Other: Integrin cell surface interactions Non-integrin membrane-ECM interactions ECM proteoglycans Itgb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000025809 Description: integrin beta 1 (fibronectin receptor beta) [Source:MGI Symbol;Acc:MGI:96610] Location: 8:129412135-129459681 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell pericyte stellate cell stromal cell smooth muscle cell fibroblast muscle cell mural cell basal cell kidney cell Other: Laminin interactions Adaptive Immune System Elastic fibre formation Itgb3 Gene Information Basic Information Ensembl ID: ENSMUSG00000020689 Description: integrin beta 3 [Source:MGI Symbol;Acc:MGI:96612] Location: 11:104498826-104561302 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell stromal cell bone cell megakaryocyte Other: Elastic fibre formation Cell surface interactions at the vascular wall Integrin cell surface interactions Kdr Gene Information Basic Information Ensembl ID: ENSMUSG00000062960 Description: kinase insert domain protein receptor [Source:MGI Symbol;Acc:MGI:96683] Location: 5:76093487-76139118 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell glial cell Other: Signaling by Receptor Tyrosine Kinases Kit Gene Information Basic Information Ensembl ID: ENSMUSG00000005672 Description: KIT proto-oncogene receptor tyrosine kinase [Source:MGI Symbol;Acc:MGI:96677] Location: 5:75735576-75817382 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell natural killer cell interneuron epithelial cell intercalated cell tuft cell mast cell innate lymphoid cell hematopoietic stem cell progenitor cell dendritic cell Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Kl Gene Information Basic Information Ensembl ID: ENSMUSG00000058488 Description: klotho [Source:MGI Symbol;Acc:MGI:1101771] Location: 5:150876072-150917282 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: MAPK family signaling cascades Intracellular signaling by second messengers Signaling by Receptor Tyrosine Kinases Mmp9 Gene Information Basic Information Ensembl ID: ENSMUSG00000017737 Description: matrix metallopeptidase 9 [Source:MGI Symbol;Acc:MGI:97011] Location: 2:164782700-164797770 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell bone cell granulocyte monocyte Other: Degradation of the extracellular matrix Collagen formation Innate Immune System Ncf4 Gene Information Basic Information Ensembl ID: ENSMUSG00000071715 Description: neutrophil cytosolic factor 4 [Source:MGI Symbol;Acc:MGI:109186] Location: 15:78129001-78146780 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell dendritic cell erythrocyte granulocyte monocyte Other: Adaptive Immune System Innate Immune System Cellular responses to stress Nrp1 Gene Information Basic Information Ensembl ID: ENSMUSG00000025810 Description: neuropilin 1 [Source:MGI Symbol;Acc:MGI:106206] Location: 8:129085085-129229844 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: Regulatory T cell Other: Signaling by Receptor Tyrosine Kinases Nervous system development Ptn Gene Information Basic Information Ensembl ID: ENSMUSG00000029838 Description: pleiotrophin [Source:MGI Symbol;Acc:MGI:97804] Location: 6:36691864-36787155 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stellate cell stromal cell stem cell endothelial cell glial cell mesenchymal cell Other: Signaling by Receptor Tyrosine Kinases Stat3 Gene Information Basic Information Ensembl ID: ENSMUSG00000004040 Description: signal transducer and activator of transcription 3 [Source:MGI Symbol;Acc:MGI:103038] Location: 11:100775924-100830366 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Cytokine Signaling in Immune system Signaling by Non-Receptor Tyrosine Kinases Signaling by Receptor Tyrosine Kinases Thbs4 Gene Information Basic Information Ensembl ID: ENSMUSG00000021702 Description: thrombospondin 4 [Source:MGI Symbol;Acc:MGI:1101779] Location: 13:92888098-92931326 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast epithelial cell Other: Signaling by Receptor Tyrosine Kinases Tlr9 Gene Information Basic Information Ensembl ID: ENSMUSG00000045322 Description: toll-like receptor 9 [Source:MGI Symbol;Acc:MGI:1932389] Location: 9:106099797-106104082 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Innate Immune System Signaling by Receptor Tyrosine Kinases
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Pathway Hierarchies & Genes RAC1 GTPase cycle (1 genes) Signal Transduction Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Signaling by Rho GTPases RHO GTPase cycle RAC1 GTPase cycle 1 genes RHO GTPases Activate Formins (1 genes) Signal Transduction Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Signaling by Rho GTPases RHO GTPase Effectors RHO GTPases Activate Formins 1 genes RHO GTPases Activate NADPH Oxidases (2 genes) Signal Transduction Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Signaling by Rho GTPases RHO GTPase Effectors RHO GTPases Activate NADPH Oxidases 2 genes RHO GTPases activate IQGAPs (1 genes) Signal Transduction Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Signaling by Rho GTPases RHO GTPase Effectors RHO GTPases activate IQGAPs 1 genes RHO GTPases activate PAKs (2 genes) Signal Transduction Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Signaling by Rho GTPases RHO GTPase Effectors RHO GTPases activate PAKs 2 genes RHOA GTPase cycle (2 genes) Signal Transduction Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Signaling by Rho GTPases RHO GTPase cycle RHOA GTPase cycle 2 genes RND1 GTPase cycle (1 genes) Signal Transduction Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Signaling by Rho GTPases RHO GTPase cycle RND1 GTPase cycle 1 genes	Cav1 Gene Information Basic Information Ensembl ID: ENSMUSG00000007655 Description: caveolin 1%2C caveolae protein [Source:MGI Symbol;Acc:MGI:102709] Location: 6:17306334-17341451 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by WNT Metabolism of nitric oxide: NOS3 activation and regulation Cell surface interactions at the vascular wall Cenpf Gene Information Basic Information Ensembl ID: ENSMUSG00000026605 Description: centromere protein F [Source:MGI Symbol;Acc:MGI:1313302] Location: 1:189372803-189420283 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stromal cell neuron progenitor cell granulocyte Other: Cell Cycle, Mitotic Cell Cycle Checkpoints Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Cybb Gene Information Basic Information Ensembl ID: ENSMUSG00000015340 Description: cytochrome b-245%2C beta polypeptide [Source:MGI Symbol;Acc:MGI:88574] Location: X:9301491-9354010 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: monocyte Other: Adaptive Immune System Innate Immune System Cellular responses to stress Epsti1 Gene Information Basic Information Ensembl ID: ENSMUSG00000022014 Description: epithelial stromal interaction 1 [Source:MGI Symbol;Acc:MGI:1915168] Location: 14:78141679-78240097 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: natural killer cell phagocyte monocyte Specialized T cell Other: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Itgb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000025809 Description: integrin beta 1 (fibronectin receptor beta) [Source:MGI Symbol;Acc:MGI:96610] Location: 8:129412135-129459681 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell pericyte stellate cell stromal cell smooth muscle cell fibroblast muscle cell mural cell basal cell kidney cell Other: Laminin interactions Adaptive Immune System Elastic fibre formation Myh11 Gene Information Basic Information Ensembl ID: ENSMUSG00000018830 Description: myosin%2C heavy polypeptide 11%2C smooth muscle [Source:MGI Symbol;Acc:MGI:102643] Location: 16:14012399-14109236 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte endothelial cell smooth muscle cell fibroblast mural cell mesangial cell Other: Smooth Muscle Contraction Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Mylk Gene Information Basic Information Ensembl ID: ENSMUSG00000022836 Description: myosin%2C light polypeptide kinase [Source:MGI Symbol;Acc:MGI:894806] Location: 16:34565580-34822790 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stellate cell pericyte endothelial cell stem cell stromal cell smooth muscle cell mural cell retinal pigment epithelial cell photoreceptor cell mesangial cell Other: Smooth Muscle Contraction Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Ncf4 Gene Information Basic Information Ensembl ID: ENSMUSG00000071715 Description: neutrophil cytosolic factor 4 [Source:MGI Symbol;Acc:MGI:109186] Location: 15:78129001-78146780 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell dendritic cell erythrocyte granulocyte monocyte Other: Adaptive Immune System Innate Immune System Cellular responses to stress Tfrc Gene Information Basic Information Ensembl ID: ENSMUSG00000022797 Description: transferrin receptor [Source:MGI Symbol;Acc:MGI:98822] Location: 16:32427738-32451612 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: progenitor cell erythroid progenitor cell erythroblast erythroid cell T cell Other: Membrane Trafficking Iron uptake and transport Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Tubb3 Gene Information Basic Information Ensembl ID: ENSMUSG00000062380 Description: tubulin%2C beta 3 class III [Source:MGI Symbol;Acc:MGI:107813] Location: 8:124138163-124148754 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: blood cell neuron motor neuron Other: Cytokine Signaling in Immune system Adaptive Immune System Macroautophagy
Signaling by TGFB family members Pathway Hierarchies & Genes TGFBR3 regulates TGF-beta signaling (1 genes) Signal Transduction Signaling by TGFB family members Signaling by TGF-beta Receptor Complex TGF-beta receptor signaling activates SMADs Downregulation of TGF-beta receptor signaling Signaling by TGFBR3 TGFBR3 regulates TGF-beta signaling 1 genes TGF-beta receptor signaling activates SMADs (3 genes) Signal Transduction Signaling by TGFB family members Signaling by TGF-beta Receptor Complex TGF-beta receptor signaling activates SMADs 3 genes Signaling by BMP (1 genes) Signal Transduction Signaling by TGFB family members Signaling by BMP 1 genes	Bmp2 Gene Information Basic Information Ensembl ID: ENSMUSG00000027358 Description: bone morphogenetic protein 2 [Source:MGI Symbol;Acc:MGI:88177] Location: 2:133394079-133404805 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell stromal cell Other: Elastic fibre formation Signaling by TGFB family members Itga8 Gene Information Basic Information Ensembl ID: ENSMUSG00000026768 Description: integrin alpha 8 [Source:MGI Symbol;Acc:MGI:109442] Location: 2:12111443-12306733 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast smooth muscle cell epithelial cell mesenchymal stem cell Other: Elastic fibre formation Integrin cell surface interactions ECM proteoglycans Itgb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000025809 Description: integrin beta 1 (fibronectin receptor beta) [Source:MGI Symbol;Acc:MGI:96610] Location: 8:129412135-129459681 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell pericyte stellate cell stromal cell smooth muscle cell fibroblast muscle cell mural cell basal cell kidney cell Other: Laminin interactions Adaptive Immune System Elastic fibre formation Itgb3 Gene Information Basic Information Ensembl ID: ENSMUSG00000020689 Description: integrin beta 3 [Source:MGI Symbol;Acc:MGI:96612] Location: 11:104498826-104561302 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell stromal cell bone cell megakaryocyte Other: Elastic fibre formation Cell surface interactions at the vascular wall Integrin cell surface interactions Tgfb1 Gene Information Basic Information Ensembl ID: ENSMUSG00000002603 Description: transforming growth factor%2C beta 1 [Source:MGI Symbol;Acc:MGI:98725] Location: 7:25386427-25404502 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: dendritic cell hematopoietic stem cell phagocyte monocyte leukocyte megakaryocyte Other: Cell surface interactions at the vascular wall Non-integrin membrane-ECM interactions Elastic fibre formation
Signaling by WNT Pathway Hierarchies & Genes Deactivation of the beta-catenin transactivating complex (2 genes) Signal Transduction Signaling by WNT TCF dependent signaling in response to WNT Deactivation of the beta-catenin transactivating complex 2 genes Disassembly of the destruction complex and recruitment of AXIN to the membrane (1 genes) Signal Transduction Signaling by WNT TCF dependent signaling in response to WNT Disassembly of the destruction complex and recruitment of AXIN to the membrane 1 genes WNT ligand biogenesis and trafficking (1 genes) Signal Transduction Signaling by WNT TCF dependent signaling in response to WNT WNT ligand biogenesis and trafficking 1 genes	Cav1 Gene Information Basic Information Ensembl ID: ENSMUSG00000007655 Description: caveolin 1%2C caveolae protein [Source:MGI Symbol;Acc:MGI:102709] Location: 6:17306334-17341451 (+) Biotype: protein_coding Species: Mus musculus Annotations Other: Signaling by WNT Metabolism of nitric oxide: NOS3 activation and regulation Cell surface interactions at the vascular wall Sox17 Gene Information Basic Information Ensembl ID: ENSMUSG00000025902 Description: SRY (sex determining region Y)-box 17 [Source:MGI Symbol;Acc:MGI:107543] Location: 1:4561154-4567577 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell embryonic cell Other: Signaling by WNT Sox9 Gene Information Basic Information Ensembl ID: ENSMUSG00000000567 Description: SRY (sex determining region Y)-box 9 [Source:MGI Symbol;Acc:MGI:98371] Location: 11:112673050-112678586 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell stromal cell tuft cell muscle cell chondrocyte bone cell progenitor cell hepatocyte natural killer cell stem cell Other: Signaling by WNT RNA Polymerase II Transcription Wnt3 Gene Information Basic Information Ensembl ID: ENSMUSG00000000125 Description: wingless-type MMTV integration site family%2C member 3 [Source:MGI Symbol;Acc:MGI:98955] Location: 11:103664976-103708783 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: club cell Other: Signaling by WNT
Smooth Muscle Contraction Pathway Hierarchies & Genes Smooth Muscle Contraction (3 genes) Muscle contraction Smooth Muscle Contraction 3 genes	Itga1 Gene Information Basic Information Ensembl ID: ENSMUSG00000042284 Description: integrin alpha 1 [Source:MGI Symbol;Acc:MGI:96599] Location: 13:115089632-115238500 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell pericyte stellate cell epithelial cell mural cell Other: Integrin cell surface interactions Smooth Muscle Contraction Myh11 Gene Information Basic Information Ensembl ID: ENSMUSG00000018830 Description: myosin%2C heavy polypeptide 11%2C smooth muscle [Source:MGI Symbol;Acc:MGI:102643] Location: 16:14012399-14109236 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte endothelial cell smooth muscle cell fibroblast mural cell mesangial cell Other: Smooth Muscle Contraction Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Mylk Gene Information Basic Information Ensembl ID: ENSMUSG00000022836 Description: myosin%2C light polypeptide kinase [Source:MGI Symbol;Acc:MGI:894806] Location: 16:34565580-34822790 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: fibroblast stellate cell pericyte endothelial cell stem cell stromal cell smooth muscle cell mural cell retinal pigment epithelial cell photoreceptor cell mesangial cell Other: Smooth Muscle Contraction Signaling by Rho GTPases, Miro GTPases and RHOBTB3
Striated Muscle Contraction Pathway Hierarchies & Genes Striated Muscle Contraction (2 genes) Muscle contraction Striated Muscle Contraction 2 genes	Actn3 Gene Information Basic Information Ensembl ID: ENSMUSG00000006457 Description: actinin alpha 3 [Source:MGI Symbol;Acc:MGI:99678] Location: 19:4911244-4927937 (-) Biotype: protein_coding Species: Mus musculus Annotations Other: Striated Muscle Contraction Des Gene Information Basic Information Ensembl ID: ENSMUSG00000026208 Description: desmin [Source:MGI Symbol;Acc:MGI:94885] Location: 1:75336973-75345223 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: stellate cell pericyte cardiomyocyte endothelial cell fibroblast smooth muscle cell muscle cell skeletal muscle cell mural cell Other: Striated Muscle Contraction
Transmission across Chemical Synapses Pathway Hierarchies & Genes Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (1 genes) Neuronal System Transmission across Chemical Synapses Neurotransmitter receptors and postsynaptic signal transmission GABA receptor activation GABA B receptor activation Activation of GABAB receptors Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 1 genes Trafficking of GluR2-containing AMPA receptors (1 genes) Neuronal System Transmission across Chemical Synapses Neurotransmitter receptors and postsynaptic signal transmission Glutamate binding, activation of AMPA receptors and synaptic plasticity Trafficking of AMPA receptors Trafficking of GluR2-containing AMPA receptors 1 genes GABA synthesis (1 genes) Neuronal System Transmission across Chemical Synapses Neurotransmitter release cycle GABA synthesis, release, reuptake and degradation GABA synthesis 1 genes Glutamate Neurotransmitter Release Cycle (1 genes) Neuronal System Transmission across Chemical Synapses Neurotransmitter release cycle Glutamate Neurotransmitter Release Cycle 1 genes Serotonin Neurotransmitter Release Cycle (1 genes) Neuronal System Transmission across Chemical Synapses Neurotransmitter release cycle Serotonin Neurotransmitter Release Cycle 1 genes	Gad1 Gene Information Basic Information Ensembl ID: ENSMUSG00000070880 Description: glutamate decarboxylase 1 [Source:MGI Symbol;Acc:MGI:95632] Location: 2:70383416-70432358 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: interneuron inhibitory neuron Other: Transmission across Chemical Synapses Gria2 Gene Information Basic Information Ensembl ID: ENSMUSG00000033981 Description: glutamate receptor%2C ionotropic%2C AMPA2 (alpha 2) [Source:MGI Symbol;Acc:MGI:95809] Location: 3:80588757-80710142 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron Other: Transmission across Chemical Synapses Kcnj16 Gene Information Basic Information Ensembl ID: ENSMUSG00000051497 Description: potassium inwardly-rectifying channel%2C subfamily J%2C member 16 [Source:MGI Symbol;Acc:MGI:1314842] Location: 11:110858859-110918794 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Transmission across Chemical Synapses Potassium Channels Slc17a7 Gene Information Basic Information Ensembl ID: ENSMUSG00000070570 Description: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter)%2C member 7 [Source:MGI Symbol;Acc:MGI:1920211] Location: 7:44813373-44825566 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron excitatory neuron Other: Transmission across Chemical Synapses SLC-mediated transmembrane transport Snap25 Gene Information Basic Information Ensembl ID: ENSMUSG00000027273 Description: synaptosomal-associated protein 25 [Source:MGI Symbol;Acc:MGI:98331] Location: 2:136555373-136624348 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: neuron endocrine cell Other: Cytokine Signaling in Immune system Innate Immune System Transmission across Chemical Synapses
Visual phototransduction Pathway Hierarchies & Genes Activation of the phototransduction cascade (2 genes) Sensory Perception Visual phototransduction The canonical retinoid cycle in rods (twilight vision) The phototransduction cascade 1 genes Activation of the phototransduction cascade 1 genes Retinoid metabolism and transport (2 genes) Sensory Perception Visual phototransduction Retinoid metabolism and transport 2 genes	Lrp2 Gene Information Basic Information Ensembl ID: ENSMUSG00000027070 Description: low density lipoprotein receptor-related protein 2 [Source:MGI Symbol;Acc:MGI:95794] Location: 2:69254684-69416409 (-) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: epithelial cell Other: Metabolism of vitamins and cofactors Membrane Trafficking Visual phototransduction Rbp1 Gene Information Basic Information Ensembl ID: ENSMUSG00000046402 Description: retinol binding protein 1%2C cellular [Source:MGI Symbol;Acc:MGI:97876] Location: 9:98305014-98328628 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: endothelial cell fibroblast stellate cell stem cell glial cell epithelial cell Other: Metabolism of vitamins and cofactors Visual phototransduction Rho Gene Information Basic Information Ensembl ID: ENSMUSG00000030324 Description: rhodopsin [Source:MGI Symbol;Acc:MGI:97914] Location: 6:115908709-115916997 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: photoreceptor cell Other: Visual phototransduction Signaling by GPCR Cilium Assembly Sdc1 Gene Information Basic Information Ensembl ID: ENSMUSG00000020592 Description: syndecan 1 [Source:MGI Symbol;Acc:MGI:1349162] Location: 12:8821323-8843715 (+) Biotype: protein_coding Species: Mus musculus Annotations Cell Type Markers: pericyte stem cell epithelial cell pneumocyte Naive B cell basal cell plasma cell leukocyte T cell Specialized T cell Other: Cytokine Signaling in Immune system Metabolism of vitamins and cofactors Cell surface interactions at the vascular wall

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